Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00338 (show subtarget assignments)	1	cloned	No	FTT0876c	56707980	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1UM0	47.4%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00808 (show subtarget assignments)	1	cloned	No	SACOL1868	57284789	splB	serine protease SplB	240	Drug Target Function	Phase 2: March 2008	2VID	85%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00806 (show subtarget assignments)	1	cloned	No	SACOL1861	57284782	hsdS	type I restriction-modification enzyme, ...	399	Drug Target Function	Phase 2: March 2008	1YF2	27.8%	Staphylococcus aureus	DNA metabolism	Restriction/modification

IDP00434 (show subtarget assignments)	1	cloned	No	YPO0796	16121108	lysA	diaminopimelate decarboxylase	420	Drug Target Function	Phase 2: March 2008	1KNW	76.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02632 (show subtarget assignments)	1	cloned	No	lmo0582	16802625	iap	P60 extracellular protein, invasion asso...	482	Known virulence-Invasion; Possible Vaccine Candidate; Known Essential Genes; PMI...	Phase 3: June 2008	3H41	14.1%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP01845 (show subtarget assignments)	1	cloned	No	STM0017	16763407		hypothetical protein STM0017 [Salmonella...	147	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP02208 (show subtarget assignments)	1	cloned	No	FTT0964c	56708058	ffh	signal recognition particle protein, Ffh...	458	Conserved; Drug target functions	Phase 3: June 2008	2XXA	59%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP00179 (show subtarget assignments)	1	cloned	No	YPO0277	16120616	-	putative transmembrane transport protein...	428	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00802 (show subtarget assignments)	1	cloned	No	SACOL1704	57284716	mreC	rod shape-determining protein MreC	280	Conserved Gene / Pathway	Phase 2: March 2008	2J5U	29.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01639 (show subtarget assignments)	1	cloned	No	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02657 (show subtarget assignments)	1	cloned	No	lmo0203	16802249	mpl	Zinc metalloproteinase precursor [Lister...	510	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...	Phase 3: June 2008	1BQB	27.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02626 (show subtarget assignments)	1	cloned	No	Cj1614	15792919	chuA	TonB-dependent heme receptor [Campylobac...	709	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3FHH	23.3%	Campylobacter jejuni	Regulatory functions	Other

IDP01835 (show subtarget assignments)	1	cloned	No	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00022 (show subtarget assignments)	1	cloned	No	BA_5578	81714842		UDP-N-acetylglucosamine 1-carboxyvinyltr...	429	Drug Target Homolog	Phase 1: October 2007	3SG1	49.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01858 (show subtarget assignments)	1	cloned	No	CBU_0993	29541575	def	peptide deformylase [Coxiella burnetii R...	170	Conserved; Drug target functions	Phase 3: June 2008	1N5N	47.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP02633 (show subtarget assignments)	1	cloned	No	Cj1431c	15792749		hypothetical protein Cj1431c [Campylobac...	582	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02683 (show subtarget assignments)	1	cloned	No	GBAA2008	47527306		ribosome-associated GTPase [Bacillus ant...	364	Conserved; Essential;	Phase 3: June 2008	1T9H	25.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04554 (show subtarget assignments)	1	cloned	No	STM0791_1_506	16764154	hutH	histidine ammonia-lyase [Salmonella typh...	506	Salmonella essential protein	Phase 4: April 2009	1GK2	76.5%	Salmonella enterica

IDP04599 (show subtarget assignments)	1	cloned	No	BAS2268	49185277		aspartate-semialdehyde dehydrogenase [Ba...	347	Proposed to be essential proteins	Phase 4: April 2009	2GYY	55.3%	Bacillus anthracis

IDP04510 (show subtarget assignments)	1	cloned	No	CPF_2272	110798867	era	GTP-binding protein Era [Clostridium per...	296	conserved gene; putative drug target function;	Phase 4: April 2009	3IEV	41.9%	Clostridium perfringens	Cellular processes	Cell division

IDP01825 (show subtarget assignments)	1	cloned	No	STM2265	16765593	ada	O6-methylguanine-DNA methyltransferase/t...	353	Conserved; Drug target functions	Phase 3: June 2008	1SFE	37.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP04511 (show subtarget assignments)	1	cloned	No	CPF_2297	110798696		stage II sporulation protein P [Clostrid...	361	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00794 (show subtarget assignments)	1	cloned	No	SACOL1194	57284479	pbp1	penicillin-binding protein 1	744	Drug Target Function	Phase 2: March 2008	1PYY	30.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02620 (show subtarget assignments)	1	cloned	No	lmo0205	16802251	plcB	phospholipase C [Listeria monocytogenes ...	289	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...	Phase 3: June 2008	1AH7	32.5%	Listeria monocytogenes	Cellular processes	Toxin production and resistance

IDP04514 (show subtarget assignments)	1	cloned	No	CPF_2662	110798713		putative spore-cortex-lytic enzyme [Clos...	200	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02621 (show subtarget assignments)	1	cloned	No	FTT0913	56708014		hypothetical protein FTT0913 [Francisell...	155	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP02618 (show subtarget assignments)	1	cloned	No	STM2205	16765535	fruK	1-phosphofructokinase [Salmonella typhim...	312	Conserved; Drug target functions	Phase 3: June 2008	3CQD	31.1%	Salmonella enterica	Energy metabolism	Glycolysis/gluconeogenesis

IDP04508 (show subtarget assignments)	1	cloned	No	CPF_0372	110799482		polysaccharide deacetylase family protei...	306	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NY1	17.6%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02162 (show subtarget assignments)	1	cloned	No	FTT1463c	56708504	wbtB	galactosyl transferase [Francisella tula...	205	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP00176 (show subtarget assignments)	1	cloned	No	YPO4024	16124147	-	putative iron transport permease	335	Virulence	Phase 1: October 2007	2QI9	23.9%	Yersinia pestis	Hypothetical proteins	Conserved

IDP02619 (show subtarget assignments)	1	cloned	No	GBAA1372	47526645	nrdF	ribonucleotide-diphosphate reductase sub...	322	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	4DR0	58.4%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP04516 (show subtarget assignments)	1	cloned	No	CPF_2815	110800431	purR	purine operon repressor [Clostridium per...	267	conserved gene; putative drug target function;	Phase 4: April 2009	1O57	40.8%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01829 (show subtarget assignments)	1	cloned	No	lmo0051	16802099		hypothetical protein lmo0051 [Listeria m...	242	Known virulence-Regulation; PMID:17675424	Phase 3: June 2008	3BS1	15.7%	Listeria monocytogenes	Regulatory functions	Other

IDP01820 (show subtarget assignments)	1	cloned	No	GBAA5463	47530777	thiC	thiamine biosynthesis protein ThiC [Baci...	586	Conserved; Drug target functions	Phase 3: June 2008	3EPM	66.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP02163 (show subtarget assignments)	1	cloned	No	GBAA3914	47529205		phosphodiesterase [Bacillus anthracis st...	520	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	General

IDP01822 (show subtarget assignments)	1	cloned	No	FTT0317	56707470	uppS	undecaprenyl pyrophosphate synthetase [F...	257	Conserved; Drug target functions	Phase 3: June 2008	1JP3	43.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00782 (show subtarget assignments)	1	cloned	No	SACOL0857	57284318		staphylocoagulase precursor, putative	508	Conserved Gene / Pathway	Phase 2: March 2008	2A1D	16.9%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP02158 (show subtarget assignments)	1	cloned	No	Cj1617	15792922	chuD	putative haemin uptake system periplasmi...	268	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3GFV	27%	Campylobacter jejuni	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP04504 (show subtarget assignments)	1	cloned	No	VC2307	15642305		2-dehydropantoate 2-reductase [Vibrio ch...	296	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KS9	43.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02159 (show subtarget assignments)	1	cloned	No	CBU_1892	29542449	aroK	shikimate kinase [Coxiella burnetii RSA ...	179	Conserved; Drug target functions	Phase 3: June 2008	3TRF	100%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01824 (show subtarget assignments)	1	cloned	No	STM3197	16766497	glgS	glycogen synthesis protein GlgS [Salmone...	69	Conserved; Drug target functions	Phase 3: June 2008	1RRZ	73.9%	Salmonella enterica	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02622 (show subtarget assignments)	1	cloned	No	CBU_0109	29540729		ABC transporter, periplasmic substrate-b...	267	Conserved; Drug target functions	Phase 3: June 2008	3TQW	88.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00174 (show subtarget assignments)	1	cloned	No	YPO1140	16121437	-	putative membrane protein	272	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00778 (show subtarget assignments)	1	cloned	No	SACOL0668	57284264		hydrolase, alpha/beta hydrolase fold fam...	266	Drug Target Function	Phase 2: March 2008	1VA4	26.1%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP01377 (show subtarget assignments)	1	cloned	No	VC0409	15640436		MSHA pilin protein MshA	178	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP04503 (show subtarget assignments)	1	cloned	No	VC2289	15642287		thiamin biosynthesis lipoprotein ApbE [V...	367	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3PND	39.2%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP04506 (show subtarget assignments)	1	cloned	No	VCA0719	15601475		sensor histide kinase [Vibrio cholerae O...	315	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	26.3%	Vibrio cholerae	Regulatory functions	Other

IDP04517 (show subtarget assignments)	1	cloned	No	CPF_2840	110799025	ksgA	dimethyladenosine transferase [Clostridi...	285	conserved gene; putative drug target function;	Phase 4: April 2009	3FUT	35.1%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP01480 (show subtarget assignments)	1	cloned	No	VCA0116	15600887		clpB protein	869	Drug Target Function	Phase 2: March 2008	1QVR	36.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04489 (show subtarget assignments)	1	cloned	No	YPO3728	115349344	purH	bifunctional purine biosynthesis protein...	529	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	44.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04492 (show subtarget assignments)	1	cloned	No	YPO3834	218930837	pldA	phospholipase A [Yersinia pestis CO92]	292	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1FW2	69.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP00173 (show subtarget assignments)	1	cloned	No	YPO2922	16123109	-	putative membrane protein	486	Virulence	Phase 1: October 2007	3K4U	14.4%	Yersinia pestis	Unknown function	General

IDP00774 (show subtarget assignments)	1	cloned	No	SACOL0597	57285613		chaperone protein HchA	292	Drug Target Function	Phase 2: March 2008	1IZY	54.1%	Staphylococcus aureus	Hypothetical proteins	Conserved

IDP01817 (show subtarget assignments)	1	cloned	No	STM1143	16764499	csgB	curlin minor subunit [Salmonella typhimu...	151	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Pathogenesis

IDP04493 (show subtarget assignments)	1	cloned	No	YPO4089	115349677		pyridoxal-phosphate dependent enzyme [Ye...	320	putative drug target function;	Phase 4: April 2009	3HMK	36.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02605 (show subtarget assignments)	1	cloned	No	YPO3502	16123648	hflB	ATP-dependent metalloprotease [Yersinia ...	644	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	2DHR	40.7%	Yersinia pestis	Cellular processes	Cell division

IDP01499 (show subtarget assignments)	1	cloned	No	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04481 (show subtarget assignments)	1	cloned	No	YPO3204	115348844	nmpB	phosphate regulon sensor protein PhoR [Y...	438	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	19.9%	Yersinia pestis	Regulatory functions	Other

IDP01378 (show subtarget assignments)	1	cloned	No	VC0410	15640437		MSHA pilin protein MshC	162	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01831 (show subtarget assignments)	1	cloned	No	GBAA3985	47529275	ftsY	signal recognition particle-docking prot...	329	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VMA	48.6%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02611 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0111	47566431		M23/37 family peptidase [Bacillus anthra...	523	Drug target motif; Vaccine Target	Phase 3: June 2008	2GU1	10.1%	Bacillus anthracis	N/A	N/A

IDP04486 (show subtarget assignments)	1	cloned	No	YPO3597	115349218		conserved hypothetical protein [Yersinia...	448	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP04499 (show subtarget assignments)	1	cloned	No	VC0869	15640885		phosphoribosylformylglycinamidine syntha...	1297	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	73.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00417 (show subtarget assignments)	1	cloned	No	YPO2604	16122817	pbpA	penicillin-binding protein 2	631	Drug Target Function	Phase 2: March 2008	3OC2	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04475 (show subtarget assignments)	1	cloned	No	YPO2772	115348455	purF	amidophosphoribosyltransferase [Yersinia...	505	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1ECB	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02602 (show subtarget assignments)	1	cloned	No	Cj1148	15792472	waaF	ADP-heptose--LPS heptosyltransferase II ...	319	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	1PSW	24.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00171 (show subtarget assignments)	1	cloned	No	YPO0452	16120781	-	putative soluble lytic murein transglyco...	639	Similar to Essential SALTY	Phase 1: October 2007	1QSA	61.8%	Yersinia pestis	Hypothetical proteins	Conserved

IDP04470 (show subtarget assignments)	1	cloned	No	YPO2306	218929398		putative amino acid antiporter [Yersinia...	463	putative drug target function;	Phase 4: April 2009	3HQK	26.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04476 (show subtarget assignments)	1	cloned	No	YPO2773	115348456	ubiX	probable 3-octaprenyl-4-hydroxybenzoate ...	190	conserved gene; putative drug target function;	Phase 4: April 2009	1SBZ	51.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01819 (show subtarget assignments)	1	cloned	No	STM1145	16764501	csgC	putative autoagglutination protein [Salm...	108	Conserved; Drug target functions	Phase 3: June 2008	2Y2T	64.8%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02599 (show subtarget assignments)	1	cloned	No	Cj1138	15792463		putative galactosyltransferase [Campylob...	389	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	22%	Campylobacter jejuni	Energy metabolism	Sugars

IDP04468 (show subtarget assignments)	1	cloned	No	YPO2205	115347912	trpC	tryptophan biosynthesis protein TrpCF [Y...	475	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PII	69.3%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP02623 (show subtarget assignments)	1	cloned	No	Cj1430c	15792748		putative nucleotide-sugar epimerase/dehy...	181	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1DZR	30.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00755 (show subtarget assignments)	1	cloned	No	SACOL0099	57286648	sirA	iron compound ABC transporter, iron comp...	330	Conserved Gene / Pathway	Phase 2: March 2008	3MWF	89.1%	Staphylococcus aureus	Cell envelope	Other

IDP04463 (show subtarget assignments)	1	cloned	No	YPO1959	115347684	narR	nitrate/nitrite sensor protein [Yersinia...	593	conserved gene; putative drug target function;	Phase 4: April 2009	3EZH	8.4%	Yersinia pestis	Energy metabolism	Anaerobic

IDP04469 (show subtarget assignments)	1	cloned	No	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04501 (show subtarget assignments)	1	cloned	No	VC0991	9655452		asparagine synthetase B, glutamine-hydro...	554	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CT9	75.3%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP04518 (show subtarget assignments)	1	cloned	No	CPF_2883	110799727		putative lipoprotein [Clostridium perfri...	361	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP02147 (show subtarget assignments)	1	cloned	No	YPO0134	16120477		hypothetical protein YPO0134 [Yersinia p...	791	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2OCE	61.4%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00753 (show subtarget assignments)	1	cloned	No	SACOL0052	57286607		glycosyl transferase, group 1 family pro...	503	Conserved Gene / Pathway	Phase 2: March 2008	2F9F	9.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04449 (show subtarget assignments)	1	cloned	No	YPO0816	218927995		general secretion pathway protein D [Yer...	640	putative drug target function;	Phase 4: April 2009	3EZJ	15.6%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02148 (show subtarget assignments)	1	cloned	No	GBAA0133	47525389	infA	translation initiation factor IF-1 [Baci...	72	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AH9	72.2%	Bacillus anthracis	Protein synthesis	Translation factors

IDP02149 (show subtarget assignments)	1	cloned	No	Cj1428c	15792746	fcl	putative fucose synthetase [Campylobacte...	346	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1BSV	38.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04448 (show subtarget assignments)	1	cloned	No	YPO0810	218927990		general secretion pathway protein J [Yer...	198	putative drug target function;	Phase 4: April 2009	2RET	20.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04450 (show subtarget assignments)	1	cloned	No	YPO0905	218928078	gcvP	glycine dehydrogenase [Yersinia pestis C...	959	conserved gene; putative drug target function;	Phase 4: April 2009	1WYT	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP01810 (show subtarget assignments)	1	cloned	No	STM3187	16766487	ygiB	hypothetical protein STM3187 [Salmonella...	223	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP00168 (show subtarget assignments)	1	cloned	No	VC2209	15642774	vibF	nonribosomal peptide synthetase VibF, au...	2413	Virulence	Phase 1: October 2007	2VSQ	10.2%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP02145 (show subtarget assignments)	1	cloned	No	YPO1301	16121583	psaE	putative regulatory protein [Yersinia pe...	214	Involved in virulence; Drug target functions	Phase 3: June 2008			Yersinia pestis	Energy metabolism	Photosynthesis

IDP01812 (show subtarget assignments)	1	cloned	No	FTT1764c	56708759		ferredoxin [Francisella tularensis subsp...	107	Conserved; Drug target functions	Phase 3: June 2008	1A6L	64.5%	Francisella tularensis	Energy metabolism	Electron transport

IDP00410 (show subtarget assignments)	1	cloned	No	YPO0548	16120876	ftsL	cell division protein FtsL	105	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Cell division

IDP02146 (show subtarget assignments)	1	cloned	No	Cj1426c	15792744		hypothetical protein Cj1426c [Campylobac...	283	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008			Campylobacter jejuni	Cellular processes	Other

IDP02596 (show subtarget assignments)	1	cloned	No	GBAA1269	47526536	odhB	dihydrolipoamide acetyltransferase [Baci...	418	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.1%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP04451 (show subtarget assignments)	1	cloned	No	YPO1043	218928211	ampM	methionine aminopeptidase [Yersinia pest...	263	drug target; putative drug target function;	Community Interest	1MAT	84%	Yersinia pestis	Protein fate	Protein modification and repair

IDP02140 (show subtarget assignments)	1	cloned	No	YPO1629	16121897		N-acetyl-D-glucosamine kinase [Yersinia ...	256	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2AP1	60.2%	Yersinia pestis	Unknown function	General

IDP02142 (show subtarget assignments)	1	cloned	No	CBU_0754	29541354		efflux transporter, RND family, MFP subu...	348	Conserved; Drug target functions	Phase 3: June 2008	1VF7	24.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP02587 (show subtarget assignments)	1	cloned	No	STM2571	16765891	murQ	N-acetylmuramic acid-6-phosphate etheras...	297	Conserved; Drug target functions	Phase 3: June 2008	1NRI	51.9%	Salmonella enterica	Unknown function	General

IDP02150 (show subtarget assignments)	1	cloned	No	lmo1104	16803144		hypothetical protein lmo1104 [Listeria m...	336	Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...	Phase 3: June 2008	2EVR	15.5%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP00408 (show subtarget assignments)	1	cloned	No	YPO2735	16122939	ccmB	heme exporter protein B	219	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00338
(show subtarget assignments)

1

cloned

No

FTT0876c

56707980

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1UM0

47.4%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00808
(show subtarget assignments)

1

cloned

No

SACOL1868

57284789

splB

serine protease SplB

240

Drug Target Function

Phase 2: March 2008

2VID

85%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00806
(show subtarget assignments)

1

cloned

No

SACOL1861

57284782

hsdS

type I restriction-modification enzyme, ...

399

Drug Target Function

Phase 2: March 2008

1YF2

27.8%

Staphylococcus aureus

DNA metabolism

Restriction/modification

IDP00434
(show subtarget assignments)

1

cloned

No

YPO0796

16121108

lysA

diaminopimelate decarboxylase

420

Drug Target Function

Phase 2: March 2008

1KNW

76.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02632
(show subtarget assignments)

1

cloned

No

lmo0582

16802625

iap

P60 extracellular protein, invasion asso...

482

Known virulence-Invasion; Possible Vaccine Candidate; Known Essential Genes; PMI...

Phase 3: June 2008

3H41

14.1%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP01845
(show subtarget assignments)

1

cloned

No

STM0017

16763407

hypothetical protein STM0017 [Salmonella...

147

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02208
(show subtarget assignments)

1

cloned

No

FTT0964c

56708058

ffh

signal recognition particle protein, Ffh...

458

Conserved; Drug target functions

Phase 3: June 2008

2XXA

59%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP00179
(show subtarget assignments)

1

cloned

No

YPO0277

16120616

-

putative transmembrane transport protein...

428

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00802
(show subtarget assignments)

1

cloned

No

SACOL1704

57284716

mreC

rod shape-determining protein MreC

280

Conserved Gene / Pathway

Phase 2: March 2008

2J5U

29.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01639
(show subtarget assignments)

1

cloned

No

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02657
(show subtarget assignments)

1

cloned

No

lmo0203

16802249

mpl

Zinc metalloproteinase precursor [Lister...

510

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...

Phase 3: June 2008

1BQB

27.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02626
(show subtarget assignments)

1

cloned

No

Cj1614

15792919

chuA

TonB-dependent heme receptor [Campylobac...

709

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3FHH

23.3%

Campylobacter jejuni

Regulatory functions

Other

IDP01835
(show subtarget assignments)

1

cloned

No

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00022
(show subtarget assignments)

1

cloned

No

BA_5578

81714842

UDP-N-acetylglucosamine 1-carboxyvinyltr...

429

Drug Target Homolog

Phase 1: October 2007

3SG1

49.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01858
(show subtarget assignments)

1

cloned

No

CBU_0993

29541575

def

peptide deformylase [Coxiella burnetii R...

170

Conserved; Drug target functions

Phase 3: June 2008

1N5N

47.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP02633
(show subtarget assignments)

1

cloned

No

Cj1431c

15792749

hypothetical protein Cj1431c [Campylobac...

582

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02683
(show subtarget assignments)

1

cloned

No

GBAA2008

47527306

ribosome-associated GTPase [Bacillus ant...

364

Conserved; Essential;

Phase 3: June 2008

1T9H

25.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04554
(show subtarget assignments)

1

cloned

No

STM0791_1_506

16764154

hutH

histidine ammonia-lyase [Salmonella typh...

506

Salmonella essential protein

Phase 4: April 2009

1GK2

76.5%

Salmonella enterica

IDP04599
(show subtarget assignments)

1

cloned

No

BAS2268

49185277

aspartate-semialdehyde dehydrogenase [Ba...

347

Proposed to be essential proteins

Phase 4: April 2009

2GYY

55.3%

Bacillus anthracis

IDP04510
(show subtarget assignments)

1

cloned

No

CPF_2272

110798867

era

GTP-binding protein Era [Clostridium per...

296

conserved gene; putative drug target function;

Phase 4: April 2009

3IEV

41.9%

Clostridium perfringens

Cellular processes

Cell division

IDP01825
(show subtarget assignments)

1

cloned

No

STM2265

16765593

ada

O6-methylguanine-DNA methyltransferase/t...

353

Conserved; Drug target functions

Phase 3: June 2008

1SFE

37.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP04511
(show subtarget assignments)

1

cloned

No

CPF_2297

110798696

stage II sporulation protein P [Clostrid...

361

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00794
(show subtarget assignments)

1

cloned

No

SACOL1194

57284479

pbp1

penicillin-binding protein 1

744

Drug Target Function

Phase 2: March 2008

1PYY

30.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02620
(show subtarget assignments)

1

cloned

No

lmo0205

16802251

plcB

phospholipase C [Listeria monocytogenes ...

289

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...

Phase 3: June 2008

1AH7

32.5%

Listeria monocytogenes

Cellular processes

Toxin production and resistance

IDP04514
(show subtarget assignments)

1

cloned

No

CPF_2662

110798713

putative spore-cortex-lytic enzyme [Clos...

200

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02621
(show subtarget assignments)

1

cloned

No

FTT0913

56708014

hypothetical protein FTT0913 [Francisell...

155

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP02618
(show subtarget assignments)

1

cloned

No

STM2205

16765535

fruK

1-phosphofructokinase [Salmonella typhim...

312

Conserved; Drug target functions

Phase 3: June 2008

3CQD

31.1%

Salmonella enterica

Energy metabolism

Glycolysis/gluconeogenesis

IDP04508
(show subtarget assignments)

1

cloned

No

CPF_0372

110799482

polysaccharide deacetylase family protei...

306

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NY1

17.6%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02162
(show subtarget assignments)

1

cloned

No

FTT1463c

56708504

wbtB

galactosyl transferase [Francisella tula...

205

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP00176
(show subtarget assignments)

1

cloned

No

YPO4024

16124147

-

putative iron transport permease

335

Virulence

Phase 1: October 2007

2QI9

23.9%

Yersinia pestis

Hypothetical proteins

Conserved

IDP02619
(show subtarget assignments)

1

cloned

No

GBAA1372

47526645

nrdF

ribonucleotide-diphosphate reductase sub...

322

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

4DR0

58.4%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP04516
(show subtarget assignments)

1

cloned

No

CPF_2815

110800431

purR

purine operon repressor [Clostridium per...

267

conserved gene; putative drug target function;

Phase 4: April 2009

1O57

40.8%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01829
(show subtarget assignments)

1

cloned

No

lmo0051

16802099

hypothetical protein lmo0051 [Listeria m...

242

Known virulence-Regulation; PMID:17675424

Phase 3: June 2008

3BS1

15.7%

Listeria monocytogenes

Regulatory functions

Other

IDP01820
(show subtarget assignments)

1

cloned

No

GBAA5463

47530777

thiC

thiamine biosynthesis protein ThiC [Baci...

586

Conserved; Drug target functions

Phase 3: June 2008

3EPM

66.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP02163
(show subtarget assignments)

1

cloned

No

GBAA3914

47529205

phosphodiesterase [Bacillus anthracis st...

520

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

General

IDP01822
(show subtarget assignments)

1

cloned

No

FTT0317

56707470

uppS

undecaprenyl pyrophosphate synthetase [F...

257

Conserved; Drug target functions

Phase 3: June 2008

1JP3

43.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00782
(show subtarget assignments)

1

cloned

No

SACOL0857

57284318

staphylocoagulase precursor, putative

508

Conserved Gene / Pathway

Phase 2: March 2008

2A1D

16.9%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP02158
(show subtarget assignments)

1

cloned

No

Cj1617

15792922

chuD

putative haemin uptake system periplasmi...

268

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3GFV

27%

Campylobacter jejuni

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP04504
(show subtarget assignments)

1

cloned

No

VC2307

15642305

2-dehydropantoate 2-reductase [Vibrio ch...

296

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KS9

43.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02159
(show subtarget assignments)

1

cloned

No

CBU_1892

29542449

aroK

shikimate kinase [Coxiella burnetii RSA ...

179

Conserved; Drug target functions

Phase 3: June 2008

3TRF

100%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01824
(show subtarget assignments)

1

cloned

No

STM3197

16766497

glgS

glycogen synthesis protein GlgS [Salmone...

69

Conserved; Drug target functions

Phase 3: June 2008

1RRZ

73.9%

Salmonella enterica

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02622
(show subtarget assignments)

1

cloned

No

CBU_0109

29540729

ABC transporter, periplasmic substrate-b...

267

Conserved; Drug target functions

Phase 3: June 2008

3TQW

88.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00174
(show subtarget assignments)

1

cloned

No

YPO1140

16121437

-

putative membrane protein

272

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00778
(show subtarget assignments)

1

cloned

No

SACOL0668

57284264

hydrolase, alpha/beta hydrolase fold fam...

266

Drug Target Function

Phase 2: March 2008

1VA4

26.1%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP01377
(show subtarget assignments)

1

cloned

No

VC0409

15640436

MSHA pilin protein MshA

178

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP04503
(show subtarget assignments)

1

cloned

No

VC2289

15642287

thiamin biosynthesis lipoprotein ApbE [V...

367

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3PND

39.2%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP04506
(show subtarget assignments)

1

cloned

No

VCA0719

15601475

sensor histide kinase [Vibrio cholerae O...

315

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

26.3%

Vibrio cholerae

Regulatory functions

Other

IDP04517
(show subtarget assignments)

1

cloned

No

CPF_2840

110799025

ksgA

dimethyladenosine transferase [Clostridi...

285

conserved gene; putative drug target function;

Phase 4: April 2009

3FUT

35.1%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP01480
(show subtarget assignments)

1

cloned

No

VCA0116

15600887

clpB protein

869

Drug Target Function

Phase 2: March 2008

1QVR

36.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04489
(show subtarget assignments)

1

cloned

No

YPO3728

115349344

purH

bifunctional purine biosynthesis protein...

529

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

44.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04492
(show subtarget assignments)

1

cloned

No

YPO3834

218930837

pldA

phospholipase A [Yersinia pestis CO92]

292

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1FW2

69.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP00173
(show subtarget assignments)

1

cloned

No

YPO2922

16123109

-

putative membrane protein

486

Virulence

Phase 1: October 2007

3K4U

14.4%

Yersinia pestis

Unknown function

General

IDP00774
(show subtarget assignments)

1

cloned

No

SACOL0597

57285613

chaperone protein HchA

292

Drug Target Function

Phase 2: March 2008

1IZY

54.1%

Staphylococcus aureus

Hypothetical proteins

Conserved

IDP01817
(show subtarget assignments)

1

cloned

No

STM1143

16764499

csgB

curlin minor subunit [Salmonella typhimu...

151

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Pathogenesis

IDP04493
(show subtarget assignments)

1

cloned

No

YPO4089

115349677

pyridoxal-phosphate dependent enzyme [Ye...

320

putative drug target function;

Phase 4: April 2009

3HMK

36.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02605
(show subtarget assignments)

1

cloned

No

YPO3502

16123648

hflB

ATP-dependent metalloprotease [Yersinia ...

644

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

2DHR

40.7%

Yersinia pestis

Cellular processes

Cell division

IDP01499
(show subtarget assignments)

1

cloned

No

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04481
(show subtarget assignments)

1

cloned

No

YPO3204

115348844

nmpB

phosphate regulon sensor protein PhoR [Y...

438

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

19.9%

Yersinia pestis

Regulatory functions

Other

IDP01378
(show subtarget assignments)

1

cloned

No

VC0410

15640437

MSHA pilin protein MshC

162

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01831
(show subtarget assignments)

1

cloned

No

GBAA3985

47529275

ftsY

signal recognition particle-docking prot...

329

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VMA

48.6%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02611
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0111

47566431

M23/37 family peptidase [Bacillus anthra...

523

Drug target motif; Vaccine Target

Phase 3: June 2008

2GU1

10.1%

Bacillus anthracis

N/A

IDP04486
(show subtarget assignments)

1

cloned

No

YPO3597

115349218

conserved hypothetical protein [Yersinia...

448

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP04499
(show subtarget assignments)

1

cloned

No

VC0869

15640885

phosphoribosylformylglycinamidine syntha...

1297

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

73.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00417
(show subtarget assignments)

1

cloned

No

YPO2604

16122817

pbpA

penicillin-binding protein 2

631

Drug Target Function

Phase 2: March 2008

3OC2

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04475
(show subtarget assignments)

1

cloned

No

YPO2772

115348455

purF

amidophosphoribosyltransferase [Yersinia...

505

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1ECB

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02602
(show subtarget assignments)

1

cloned

No

Cj1148

15792472

waaF

ADP-heptose--LPS heptosyltransferase II ...

319

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

1PSW

24.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00171
(show subtarget assignments)

1

cloned

No

YPO0452

16120781

-

putative soluble lytic murein transglyco...

639

Similar to Essential SALTY

Phase 1: October 2007

1QSA

61.8%

Yersinia pestis

Hypothetical proteins

Conserved

IDP04470
(show subtarget assignments)

1

cloned

No

YPO2306

218929398

putative amino acid antiporter [Yersinia...

463

putative drug target function;

Phase 4: April 2009

3HQK

26.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04476
(show subtarget assignments)

1

cloned

No

YPO2773

115348456

ubiX

probable 3-octaprenyl-4-hydroxybenzoate ...

190

conserved gene; putative drug target function;

Phase 4: April 2009

1SBZ

51.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01819
(show subtarget assignments)

1

cloned

No

STM1145

16764501

csgC

putative autoagglutination protein [Salm...

108

Conserved; Drug target functions

Phase 3: June 2008

2Y2T

64.8%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02599
(show subtarget assignments)

1

cloned

No

Cj1138

15792463

putative galactosyltransferase [Campylob...

389

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

22%

Campylobacter jejuni

Energy metabolism

Sugars

IDP04468
(show subtarget assignments)

1

cloned

No

YPO2205

115347912

trpC

tryptophan biosynthesis protein TrpCF [Y...

475

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PII

69.3%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP02623
(show subtarget assignments)

1

cloned

No

Cj1430c

15792748

putative nucleotide-sugar epimerase/dehy...

181

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1DZR

30.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00755
(show subtarget assignments)

1

cloned

No

SACOL0099

57286648

sirA

iron compound ABC transporter, iron comp...

330

Conserved Gene / Pathway

Phase 2: March 2008

3MWF

89.1%

Staphylococcus aureus

Cell envelope

Other

IDP04463
(show subtarget assignments)

1

cloned

No

YPO1959

115347684

narR

nitrate/nitrite sensor protein [Yersinia...

593

conserved gene; putative drug target function;

Phase 4: April 2009

3EZH

8.4%

Yersinia pestis

Energy metabolism

Anaerobic

IDP04469
(show subtarget assignments)

1

cloned

No

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04501
(show subtarget assignments)

1

cloned

No

VC0991

9655452

asparagine synthetase B, glutamine-hydro...

554

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CT9

75.3%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP04518
(show subtarget assignments)

1

cloned

No

CPF_2883

110799727

putative lipoprotein [Clostridium perfri...

361

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP02147
(show subtarget assignments)

1

cloned

No

YPO0134

16120477

hypothetical protein YPO0134 [Yersinia p...

791

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2OCE

61.4%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00753
(show subtarget assignments)

1

cloned

No

SACOL0052

57286607

glycosyl transferase, group 1 family pro...

503

Conserved Gene / Pathway

Phase 2: March 2008

2F9F

9.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04449
(show subtarget assignments)

1

cloned

No

YPO0816

218927995

general secretion pathway protein D [Yer...

640

putative drug target function;

Phase 4: April 2009

3EZJ

15.6%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02148
(show subtarget assignments)

1

cloned

No

GBAA0133

47525389

infA

translation initiation factor IF-1 [Baci...

72

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AH9

72.2%

Bacillus anthracis

Protein synthesis

Translation factors

IDP02149
(show subtarget assignments)

1

cloned

No

Cj1428c

15792746

fcl

putative fucose synthetase [Campylobacte...

346

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1BSV

38.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04448
(show subtarget assignments)

1

cloned

No

YPO0810

218927990

general secretion pathway protein J [Yer...

198

putative drug target function;

Phase 4: April 2009

2RET

20.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04450
(show subtarget assignments)

1

cloned

No

YPO0905

218928078

gcvP

glycine dehydrogenase [Yersinia pestis C...

959

conserved gene; putative drug target function;

Phase 4: April 2009

1WYT

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP01810
(show subtarget assignments)

1

cloned

No

STM3187

16766487

ygiB

hypothetical protein STM3187 [Salmonella...

223

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP00168
(show subtarget assignments)

1

cloned

No

VC2209

15642774

vibF

nonribosomal peptide synthetase VibF, au...

2413

Virulence

Phase 1: October 2007

2VSQ

10.2%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP02145
(show subtarget assignments)

1

cloned

No

YPO1301

16121583

psaE

putative regulatory protein [Yersinia pe...

214

Involved in virulence; Drug target functions

Phase 3: June 2008

Yersinia pestis

Energy metabolism

Photosynthesis

IDP01812
(show subtarget assignments)

1

cloned

No

FTT1764c

56708759

ferredoxin [Francisella tularensis subsp...

107

Conserved; Drug target functions

Phase 3: June 2008

1A6L

64.5%

Francisella tularensis

Energy metabolism

Electron transport

IDP00410
(show subtarget assignments)

1

cloned

No

YPO0548

16120876

ftsL

cell division protein FtsL

105

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Cell division

IDP02146
(show subtarget assignments)

1

cloned

No

Cj1426c

15792744

hypothetical protein Cj1426c [Campylobac...

283

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

Campylobacter jejuni

Cellular processes

Other

IDP02596
(show subtarget assignments)

1

cloned

No

GBAA1269

47526536

odhB

dihydrolipoamide acetyltransferase [Baci...

418

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.1%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP04451
(show subtarget assignments)

1

cloned

No

YPO1043

218928211

ampM

methionine aminopeptidase [Yersinia pest...

263

drug target; putative drug target function;

Community Interest

1MAT

84%

Yersinia pestis

Protein fate

Protein modification and repair

IDP02140
(show subtarget assignments)

1

cloned

No

YPO1629

16121897

N-acetyl-D-glucosamine kinase [Yersinia ...

256

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2AP1

60.2%

Yersinia pestis

Unknown function

General

IDP02142
(show subtarget assignments)

1

cloned

No

CBU_0754

29541354

efflux transporter, RND family, MFP subu...

348

Conserved; Drug target functions

Phase 3: June 2008

1VF7

24.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP02587
(show subtarget assignments)

1

cloned

No

STM2571

16765891

murQ

N-acetylmuramic acid-6-phosphate etheras...

297

Conserved; Drug target functions

Phase 3: June 2008

1NRI

51.9%

Salmonella enterica

Unknown function

General

IDP02150
(show subtarget assignments)

1

cloned

No

lmo1104

16803144

hypothetical protein lmo1104 [Listeria m...

336

Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...

Phase 3: June 2008

2EVR

15.5%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP00408
(show subtarget assignments)

1

cloned

No

YPO2735

16122939

ccmB

heme exporter protein B

219

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

Targets