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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 12 of 60, showing 100 records out of 5973 total, starting on record 1101
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP91015
(
show subtarget assignments
)
8
selected
No
y2404
22126288
psn
pesticin/yersiniabactin outer membrane r...
673
TonB-dependent outer membrane receptor (yersiniabactin-binding)
Community Requests
1NQF
23.8%
Yersinia pestis
IDP91019
(
show subtarget assignments
)
8
selected
No
y2821
22126698
poxB
pyruvate dehydrogenase [Yersinia pestis ...
573
potential drug target /
alternative pathway for aerobic energy metabolism
Community Requests
3EY9
79.2%
Yersinia pestis
IDP04577
(
show subtarget assignments
)
1
cloned
No
BAS0087
49183121
glutamyl-tRNA synthetase [Bacillus anthr...
485
Proposed to be essential proteins
Phase 4: April 2009
2O5R
44.4%
Bacillus anthracis
IDP91213
(
show subtarget assignments
)
8
in_pdb
4ECD
No
Blon_1598
189439475
aroC
chorismate synthase [Bifidobacterium lon...
395
potential drug target /
Shikimate pathway enzyme
Community Requests
4ECD
100%
Bifidobacterium longum
IDP91018
(
show subtarget assignments
)
8
cloned
No
y2737
22126615
hypothetical protein y2737 [Yersinia pes...
164
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP91356
(
show subtarget assignments
)
8
cloned
No
VV1_2923
27366200
DNA-binding protein H-NS [Vibrio vulnifi...
135
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1OV9
31.1%
Vibrio vulnificus
IDP04572
(
show subtarget assignments
)
1
soluble
No
BAS0005
49183044
DNA gyrase subunit B [Bacillus anthracis...
640
Proposed to be essential proteins
Phase 4: April 2009
1EI1
34.4%
Bacillus anthracis
IDP91351
(
show subtarget assignments
)
8
expressed
No
VV1_3096
27366364
rnfD
electron transport complex protein RnfD ...
355
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91350
(
show subtarget assignments
)
8
soluble
No
VV1_3114
27366381
V10 pilin [Vibrio vulnificus CMCP6]
161
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04573
(
show subtarget assignments
)
1
crystallized
No
BAS0006
49183045
DNA gyrase subunit A [Bacillus anthracis...
823
Proposed to be essential proteins
Phase 4: April 2009
2XCO
42.9%
Bacillus anthracis
IDP04574
(
show subtarget assignments
)
1
soluble
No
BAS0015
49183051
seryl-tRNA synthetase [Bacillus anthraci...
424
Proposed to be essential proteins
Phase 4: April 2009
2DQ3
57.8%
Bacillus anthracis
IDP04576
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0076
49183111
lysyl-tRNA synthetase [Bacillus anthraci...
499
Proposed to be essential proteins
Phase 4: April 2009
3A74
77.6%
Bacillus anthracis
IDP91016
(
show subtarget assignments
)
8
selected
No
y2451
22126334
hypothetical protein y2451 [Yersinia pes...
384
other biological interest /
putative iron transport protein
Community Requests
3AT7
40.9%
Yersinia pestis
IDP91355
(
show subtarget assignments
)
8
soluble
No
VV1_3022
27366292
cob(I)yrinic acid a,c-diamide adenosyltr...
211
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1G5R
59.2%
Vibrio vulnificus
IDP91353
(
show subtarget assignments
)
8
expressed
No
VV1_3072
27366341
Mu-like prophage protein gp16 [Vibrio vu...
122
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04595
(
show subtarget assignments
)
1
soluble
No
BAS0565
49183590
nicotinate phosphoribosyltransferase [Ba...
487
Proposed to be essential proteins
Phase 4: April 2009
2F7F
61.4%
Bacillus anthracis
IDP04575
(
show subtarget assignments
)
1
cloned
No
BAS0037
49183072
methionyl-tRNA synthetase [Bacillus anth...
660
Proposed to be essential proteins
Phase 4: April 2009
4DLP
36.2%
Bacillus anthracis
IDP91856
(
show subtarget assignments
)
8
selected
No
SPH_0253
169834104
MutR [Streptococcus pneumoniae Hungary19...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP04582
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0110
49183144
50S ribosomal protein L3 [Bacillus anthr...
210
Proposed to be essential proteins
Phase 4: April 2009
1NKW
53.3%
Bacillus anthracis
IDP04586
(
show subtarget assignments
)
1
cloned
No
BAS0117
49183151
50S ribosomal protein L16 [Bacillus anth...
144
Proposed to be essential proteins
Phase 4: April 2009
1VSA
60.4%
Bacillus anthracis
IDP04580
(
show subtarget assignments
)
1
cloned
No
BAS0103
49183137
DNA-directed RNA polymerase subunit beta...
1203
Proposed to be essential proteins
Phase 4: April 2009
2GHO
53.6%
Bacillus anthracis
IDP04579
(
show subtarget assignments
)
1
cloned
No
BAS0098
49183132
50S ribosomal protein L1 [Bacillus anthr...
230
Proposed to be essential proteins
Phase 4: April 2009
3QOY
56.3%
Bacillus anthracis
IDP05593
(
show subtarget assignments
)
1
cloned
No
BA_3215
30257781
hypothetical protein BA_3215 [Bacillus a...
37
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91026
(
show subtarget assignments
)
8
cloned
No
y3142
22127018
flavodoxin [Yersinia pestis KIM 10]
149
other biological interest /
oxidative stress response protein
Community Requests
2HNA
33.6%
Yersinia pestis
IDP91359
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_2847
27366129
response regulator [Vibrio vulnificus CM...
219
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1KGS
41.1%
Vibrio vulnificus
IDP04581
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0108
49183142
elongation factor Tu [Bacillus anthracis...
395
Proposed to be essential proteins
Phase 4: April 2009
3U2Q
75.4%
Bacillus anthracis
IDP04583
(
show subtarget assignments
)
1
cloned
No
BAS0111
49183145
50S ribosomal protein L4 [Bacillus anthr...
207
Proposed to be essential proteins
Phase 4: April 2009
1DMG
47.1%
Bacillus anthracis
IDP04585
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0116
49183150
30S ribosomal protein S3 [Bacillus anthr...
219
Proposed to be essential proteins
Phase 4: April 2009
1VS5
54.3%
Bacillus anthracis
IDP91361
(
show subtarget assignments
)
8
cloned
No
VV1_2840
27366122
NhaP-type Na+/H+ and K+/H+ antiporters [...
831
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91362
(
show subtarget assignments
)
8
soluble
No
VV1_2836
27366118
peptide ABC transporter permease [Vibrio...
725
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04292
(
show subtarget assignments
)
1
cloned
No
YPO0812
218927992
general secretion pathway protein H [Yer...
180
conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04584
(
show subtarget assignments
)
1
purified
No
BAS0112
49183146
50S ribosomal protein L23 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1N88
43.8%
Bacillus anthracis
IDP91365
(
show subtarget assignments
)
8
soluble
No
VV1_2710
27366000
dissimilatory sulfite reductase, gamma s...
109
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1YX3
48.6%
Vibrio vulnificus
IDP04593
(
show subtarget assignments
)
1
cloned
No
BAS0144
49183178
30S ribosomal protein S9 [Bacillus anthr...
130
Proposed to be essential proteins
Phase 4: April 2009
1VS5
55.4%
Bacillus anthracis
IDP04435
(
show subtarget assignments
)
1
expressed
No
YPCD1.91n
40548798
hypothetical protein YPCD1.91n [Yersinia...
154
virulence factor;
Phase 4: April 2009
Yersinia pestis
IDP04288
(
show subtarget assignments
)
1
expressed
No
YPCD1.08c
5832431
YPCD1.08c
hypothetical protein YPCD1.08c [Yersinia...
99
virulence factor; conserved gene;
Phase 4: April 2009
3KXE
28.3%
Yersinia pestis
IDP04591
(
show subtarget assignments
)
1
cloned
No
BAS0138
49183172
50S ribosomal protein L17 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1NKW
50.8%
Bacillus anthracis
IDP05597
(
show subtarget assignments
)
1
soluble
No
BA_3378
30257921
hypothetical protein BA_3378 [Bacillus a...
199
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04590
(
show subtarget assignments
)
1
expressed
No
BAS0136
49183170
30S ribosomal protein S11 [Bacillus anth...
129
Proposed to be essential proteins
Phase 4: April 2009
1VS5
65.9%
Bacillus anthracis
IDP91024
(
show subtarget assignments
)
8
cloned
No
y2983
22126860
outer membrane protein C2 [Yersinia pest...
371
drug resistance /
anion-specific outer membrane porin
Community Requests
3HW9
59.9%
Yersinia pestis
IDP04587
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0118
49183152
50S ribosomal protein L29 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1R73
45.5%
Bacillus anthracis
IDP04588
(
show subtarget assignments
)
1
cloned
No
BAS0130
49183164
preprotein translocase subunit SecY [Bac...
433
Proposed to be essential proteins
Phase 4: April 2009
3DIN
43.8%
Bacillus anthracis
IDP91021
(
show subtarget assignments
)
8
cloned
No
y2872
22126749
yiuR
putative outer membrane receptor [Yersin...
665
other biological interest /
putative iron-binding TonB-dependent outer membrane receptor
Community Requests
2HDF
38%
Yersinia pestis
IDP04592
(
show subtarget assignments
)
1
expressed
No
BAS0143
49183177
50S ribosomal protein L13 [Bacillus anth...
145
Proposed to be essential proteins
Phase 4: April 2009
1P85
56.6%
Bacillus anthracis
IDP05594
(
show subtarget assignments
)
1
cloned
No
BA_3333
30257878
hypothetical protein BA_3333 [Bacillus a...
182
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04436
(
show subtarget assignments
)
1
expressed
No
YPCD1.97c
5832512
YPCD1.97c
putative transposase [Yersinia pestis CO...
308
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP91022
(
show subtarget assignments
)
8
cloned
No
y2966
22126843
ompC
outer membrane porin protein C [Yersinia...
374
drug resistance /
outer membrane porin
Community Requests
2IXX
67.9%
Yersinia pestis
IDP91733
(
show subtarget assignments
)
8
selected
No
P88946_HHV8
0
449
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2DLL
6.9%
Human herpesvirus
IDP91734
(
show subtarget assignments
)
8
selected
No
PTN11_HUMAN
0
593
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2SHP
88%
Homo sapiens
IDP91736
(
show subtarget assignments
)
8
selected
No
Q51451_PSEAE
0
453
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1R4T
30.7%
Pseudomonas aeruginosa
IDP91200
(
show subtarget assignments
)
8
cloned
No
CD1911
115250958
two-component sensor histidine kinase [C...
469
virulence/pathogenesis /
The important histidine kinase for ethanolamine utilization in anaerobic bacteri...
Community Requests
Clostridium difficile
IDP91028
(
show subtarget assignments
)
8
selected
No
y3714
22127588
hypothetical protein y3714 [Yersinia pes...
259
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP04601
(
show subtarget assignments
)
1
in_pdb
3RHI
Yes
BAS3574
49186575
DNA-binding protein HU [Bacillus anthrac...
90
Proposed to be essential proteins
Phase 4: April 2009
3RHI
100%
Bacillus anthracis
IDP04614
(
show subtarget assignments
)
1
purified
No
BAS4131
49187128
glycine cleavage system aminomethyltrans...
366
Proposed to be essential proteins
Phase 4: April 2009
1YX2
66.1%
Bacillus anthracis
IDP04598
(
show subtarget assignments
)
1
cloned
No
BAS1442
49184459
dihydrodipicolinate reductase [Bacillus ...
266
Proposed to be essential proteins
Phase 4: April 2009
1C3V
40.6%
Bacillus anthracis
IDP04597
(
show subtarget assignments
)
1
expressed
No
BAS1384
49184401
resB protein [Bacillus anthracis str. St...
541
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04599
(
show subtarget assignments
)
1
cloned
No
BAS2268
49185277
aspartate-semialdehyde dehydrogenase [Ba...
347
Proposed to be essential proteins
Phase 4: April 2009
2GYY
55.3%
Bacillus anthracis
IDP04600
(
show subtarget assignments
)
1
cloned
No
BAS2547
49185555
preprotein translocase subunit SecY [Bac...
434
Proposed to be essential proteins
Phase 4: April 2009
3DIN
42.2%
Bacillus anthracis
IDP04602
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3667
49186666
transcription elongation factor NusA [Ba...
368
Proposed to be essential proteins
Phase 4: April 2009
1HH2
44%
Bacillus anthracis
IDP04604
(
show subtarget assignments
)
1
cloned
No
BAS3678
49186677
30S ribosomal protein S2 [Bacillus anthr...
233
Proposed to be essential proteins
Phase 4: April 2009
1FJG
56.2%
Bacillus anthracis
IDP04603
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3670
49186669
prolyl-tRNA synthetase [Bacillus anthrac...
566
Proposed to be essential proteins
Phase 4: April 2009
2J3L
58.1%
Bacillus anthracis
IDP91378
(
show subtarget assignments
)
8
cloned
No
VV1_1552
27364921
2-octaprenyl-6-methoxyphenyl hydroxylase...
391
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2X3N
21.2%
Vibrio vulnificus
IDP04605
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3689
49186688
ribosomal biogenesis GTPase [Bacillus an...
296
Proposed to be essential proteins
Phase 4: April 2009
1PUJ
67.2%
Bacillus anthracis
IDP91382
(
show subtarget assignments
)
8
purified
No
VV1_1470
27364854
histone acetyltransferase HPA2 [Vibrio v...
164
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1YX0
18.9%
Vibrio vulnificus
IDP91381
(
show subtarget assignments
)
8
cloned
No
VV1_1469
27364853
Beta-galactosidase/beta-glucuronidase [V...
258
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04606
(
show subtarget assignments
)
1
cloned
No
BAS3692
49186691
tRNA (guanine-N(1)-)-methyltransferase [...
244
Proposed to be essential proteins
Phase 4: April 2009
3KY7
62.3%
Bacillus anthracis
IDP05432
(
show subtarget assignments
)
1
cloned
No
BA_2714
30257323
hypothetical protein BA_2714 [Bacillus a...
31
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP91389
(
show subtarget assignments
)
8
cloned
No
VV1_1437
27364822
Type II secretory pathway, component Exe...
282
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91396
(
show subtarget assignments
)
8
crystallized
No
VV1_1047
27364479
fmt
methionyl-tRNA formyltransferase [Vibrio...
315
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3Q0I
83.2%
Vibrio vulnificus
IDP91434
(
show subtarget assignments
)
8
soluble
No
VV1_0486
27363950
ribosome-associated protein Y [Vibrio vu...
107
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1IMU
50.5%
Vibrio vulnificus
IDP04613
(
show subtarget assignments
)
1
cloned
No
BAS3890
49186888
M20/M25/M40 family peptidase [Bacillus a...
376
Proposed to be essential proteins
Phase 4: April 2009
1YSJ
35.6%
Bacillus anthracis
IDP91385
(
show subtarget assignments
)
8
soluble
No
VV1_1465
27364849
pyrB
aspartate carbamoyltransferase catalytic...
309
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2BE7
76.4%
Vibrio vulnificus
IDP04608
(
show subtarget assignments
)
1
soluble
No
BAS3704
49186703
putative glycerol-3-phosphate acyltransf...
330
Proposed to be essential proteins
Phase 4: April 2009
1VI1
66.4%
Bacillus anthracis
IDP91387
(
show subtarget assignments
)
8
in_pdb
3VCZ
No
VV1_1463
27364847
putative translation initiation inhibito...
129
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3VCZ
100%
Vibrio vulnificus
IDP91390
(
show subtarget assignments
)
8
expressed
No
VV1_1426
27364811
Lipid A core - O-antigen ligase [Vibrio ...
587
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP05603
(
show subtarget assignments
)
1
cloned
No
BA_4709
30259202
hypothetical protein BA_4709 [Bacillus a...
50
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04609
(
show subtarget assignments
)
1
soluble
No
BAS3712
49186711
ribosome-associated GTPase [Bacillus ant...
293
Proposed to be essential proteins
Phase 4: April 2009
1T9H
63.4%
Bacillus anthracis
IDP04612
(
show subtarget assignments
)
1
cloned
No
BAS3764
49186763
phospho-N-acetylmuramoyl-pentapeptide-tr...
324
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04611
(
show subtarget assignments
)
1
cloned
No
BAS3754
49186753
sporulation sigma factor SigG [Bacillus ...
289
Proposed to be essential proteins
Phase 4: April 2009
1L0O
37%
Bacillus anthracis
IDP91394
(
show subtarget assignments
)
8
purified
No
VV1_1133
27364552
hypothetical protein VV1_1133 [Vibrio vu...
201
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04610
(
show subtarget assignments
)
1
in_pdb
3RFO
No
BAS3717
49186716
methionyl-tRNA formyltransferase [Bacill...
314
Proposed to be essential proteins
Phase 4: April 2009
3RFO
100%
Bacillus anthracis
IDP91392
(
show subtarget assignments
)
8
expressed
No
VV1_1289
27364689
hypothetical protein VV1_1289 [Vibrio vu...
373
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP04311
(
show subtarget assignments
)
1
purified
No
BAS4340
49187335
50S ribosomal protein L27 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1VSA
55.2%
Bacillus anthracis
IDP04633
(
show subtarget assignments
)
1
in_pdb
4EEI
No
FTT0015
56707195
purB
adenylosuccinate lyase [Francisella tula...
432
conserved gene; putative drug target function;
Phase 4: April 2009
4EEI
100%
Francisella tularensis
IDP04618
(
show subtarget assignments
)
1
cloned
No
BAS4456
49187451
phenylalanyl-tRNA synthetase subunit alp...
344
Proposed to be essential proteins
Phase 4: April 2009
2RHQ
57.6%
Bacillus anthracis
IDP91400
(
show subtarget assignments
)
8
cloned
No
VV1_1002
27364436
ABC-type amino acid transport system, pe...
223
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3DHW
23.3%
Vibrio vulnificus
IDP04615
(
show subtarget assignments
)
1
cloned
No
BAS4297
49187293
aspartyl-tRNA synthetase [Bacillus anthr...
591
Proposed to be essential proteins
Phase 4: April 2009
1EQR
52.7%
Bacillus anthracis
IDP04617
(
show subtarget assignments
)
1
expressed
No
BAS4342
49187337
50S ribosomal protein L21 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1VSA
54.9%
Bacillus anthracis
IDP04616
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4313
49187308
S-adenosylmethionine:tRNA ribosyltransfe...
350
Proposed to be essential proteins
Phase 4: April 2009
1YY3
71.4%
Bacillus anthracis
IDP91398
(
show subtarget assignments
)
8
soluble
No
VV1_1045
27364477
trkA
potassium transporter peripheral membran...
458
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3L4B
12.7%
Vibrio vulnificus
IDP04624
(
show subtarget assignments
)
1
in_pdb
3B2B
3UWD
No
BAS4988
49187974
phosphoglycerate kinase [Bacillus anthra...
394
Proposed to be essential proteins
Phase 4: April 2009
3B2B
99.7%
Bacillus anthracis
IDP04623
(
show subtarget assignments
)
1
expressed
No
BAS4760
49187751
glucose-1-phosphate adenylyltransferase ...
376
Proposed to be essential proteins
Phase 4: April 2009
3BRK
40%
Bacillus anthracis
IDP04619
(
show subtarget assignments
)
1
in_pdb
4DIB
No
BAS4478
49187473
glyceraldehyde-3-phosphate dehydrogenase...
342
Proposed to be essential proteins
Phase 4: April 2009
4DIB
100%
Bacillus anthracis
IDP91405
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_0801
27364250
dehydrogenase [Vibrio vulnificus CMCP6]
313
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3GDO
15%
Vibrio vulnificus
IDP04622
(
show subtarget assignments
)
1
soluble
No
BAS4556
49187550
tyrosyl-tRNA synthetase [Bacillus anthra...
418
potential drug target /
Proposed to be essential proteins
Phase 4: April 2009
2TS1
70.6%
Bacillus anthracis
IDP04620
(
show subtarget assignments
)
1
cloned
No
BAS4482
49187477
DNA polymerase I [Bacillus anthracis str...
891
Proposed to be essential proteins
Phase 4: April 2009
3TAN
45%
Bacillus anthracis
IDP04621
(
show subtarget assignments
)
1
cloned
No
BAS4494
49187489
acetyl-CoA carboxylase carboxyltransfera...
324
Proposed to be essential proteins
Phase 4: April 2009
2F9I
60.2%
Bacillus anthracis
IDP91402
(
show subtarget assignments
)
8
purified
No
VV1_1001
27364435
ABC-type amino acid transport, signal tr...
250
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1GGG
31.2%
Vibrio vulnificus
IDP92053
(
show subtarget assignments
)
8
selected
No
TGME49_054900
237840493
proteasome subunit beta type 2, putative...
191
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1IRU
49%
Toxoplasma gondii
IDP92052
(
show subtarget assignments
)
8
selected
No
TGME49_053800
237840277
ribosomal protein L15, putative [Toxopla...
287
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
Toxoplasma gondii
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