Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00571 (show subtarget assignments)	1	in_pdb 3GOS	No	YPO1041	16121341	dapD	2,3,4,5-tetrahydropyridine-2-carboxylate...	274	Virulence Associated Factor	Phase 2: March 2008	3GOS	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04122 (show subtarget assignments)	1	in_pdb 3OJC	Yes	YPO2758	115348441		putative aspartate/glutamate racemase [Y...	231	conserved gene; putative drug target function;	Phase 4: April 2009	3OJC	100%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01080 (show subtarget assignments)	0	work_stopped	No	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP02612 (show subtarget assignments)	0	work_stopped	No	GBAA5170	50196964	dapF	diaminopimelate epimerase [Bacillus anth...	288	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OTN	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02346 (show subtarget assignments)	1	cloned	No	GBAA2832	47528125	dapA-1	dihydrodipicolinate synthase [Bacillus a...	298	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NA8	34.2%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02783 (show subtarget assignments)	1	expressed	No	FTT0425c	56707572	asd	aspartate-semialdehyde dehydrogenase [Fr...	364	Conserved; Drug target functions	Phase 3: June 2008	1NWC	50%	Francisella tularensis	Amino acid biosynthesis	Aspartate family

IDP01610 (show subtarget assignments)	1	in_pdb 3I1I	No	GBAA4983	47778350		homoserine O-acetyltransferase [Bacillus...	374	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I1I	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01004 (show subtarget assignments)	1	in_pdb 3G0S	Yes	STM2489	16765809	dapA	dihydrodipicolinate synthase	292	Conserved Gene / Pathway	Phase 2: March 2008	3G0S	100%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP00998 (show subtarget assignments)	1	in_crystallization_trials	No	STM2369	16765696	usg	hypothetical protein STM2369	337	Conserved Gene / Pathway	Phase 2: March 2008	2QZ9	46.6%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP02093 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1970	47527265	thrB	homoserine kinase [Bacillus anthracis st...	297	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HUL	46.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02060 (show subtarget assignments)	1	expressed	No	CBU_1051	29541627		aspartate kinase [Coxiella burnetii RSA ...	409	Conserved; Drug target functions	Phase 3: June 2008	3AAW	45.1%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02042 (show subtarget assignments)	1	cloned	No	CBU_0875	29541467	asd	aspartate-semialdehyde dehydrogenase [Co...	340	Conserved; Drug target functions	Phase 3: June 2008	2QZ9	61.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02541 (show subtarget assignments)	1	expressed	No	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP00901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0004	16763394	thrC	threonine synthase	428	Conserved Gene / Pathway	Phase 2: March 2008	1VB3	93.5%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP00477 (show subtarget assignments)	1	purified	No	YPO3845	16123980	dapF	diaminopimelate epimerase	274	Conserved Gene / Pathway	Phase 2: March 2008	1GQZ	75.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04136 (show subtarget assignments)	1	diffraction	No	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP04457 (show subtarget assignments)	1	soluble	No	YPO1386	115347145	ansB	putative L-asparaginase II precursor [Ye...	345	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1NNS	71.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP00877 (show subtarget assignments)	1	crystallized	No	STM3015	16766317	ygeA	putative racemase	235	Conserved Gene / Pathway	Phase 2: March 2008	3OJC	56.6%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01785 (show subtarget assignments)	1	expressed	No	CBU_0667	29541271	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxy...	271	Conserved; Drug target functions	Phase 3: June 2008	1KGQ	62.7%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04155 (show subtarget assignments)	1	cloned	No	VC0547	9654975		aspartokinase, alpha and beta subunits [...	395	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3L76	39.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP02380 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1969	47527264	thrC	threonine synthase [Bacillus anthracis s...	352	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZSJ	58%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP00434 (show subtarget assignments)	1	cloned	No	YPO0796	16121108	lysA	diaminopimelate decarboxylase	420	Drug Target Function	Phase 2: March 2008	1KNW	76.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04167 (show subtarget assignments)	1	cloned	No	VC1977	9656518		aspartate aminotransferase, putative [Vi...	404	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XI9	40.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP00088 (show subtarget assignments)	8	in_crystallization_trials	No	NT01ST3082	16421025	dapE	N-succinyl-diaminopimelate deacylase	375	Essential	Community Requests	3IC1	61.9%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP01731 (show subtarget assignments)	1	expressed	No	CBU_1222	29541792	dapA	dihydrodipicolinate synthase [Coxiella b...	289	Conserved; Drug target functions	Phase 3: June 2008	3QZE	55.2%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02487 (show subtarget assignments)	1	cloned	No	GBAA4218	47529511	metE	5-methyltetrahydropteroyltriglutamate--h...	762	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2NQ5	51.3%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01984 (show subtarget assignments)	1	expressed	No	CBU_0831	29541425	asnB-1	asparagine synthetase B, glutamine-hydro...	632	Conserved; Drug target functions	Phase 3: June 2008	1CT9	18.8%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02483 (show subtarget assignments)	1	cloned	No	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04704 (show subtarget assignments)	1	cloned	No	YPO0322	115346138	tyrB	aromatic-amino-acid aminotransferase [Ye...	397	conserved gene; putative drug target function;	Phase 4: April 2009	3TAT	75.6%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01701 (show subtarget assignments)	1	soluble	No	CBU_1970	29542525	dapF	diaminopimelate epimerase [Coxiella burn...	276	Conserved; Drug target functions	Phase 3: June 2008	1GQZ	48.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02467 (show subtarget assignments)	1	soluble	No	GBAA3937	47529228	asd-2	aspartate-semialdehyde dehydrogenase [Ba...	348	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GYY	60.6%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02636 (show subtarget assignments)	1	expressed	No	YPO3722	16123860	metH	B12-dependent methionine synthase [Yersi...	1231	CD; Drug target functions	Phase 3: June 2008	1K7Y	40.1%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP04501 (show subtarget assignments)	1	cloned	No	VC0991	9655452		asparagine synthetase B, glutamine-hydro...	554	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1CT9	75.3%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP02669 (show subtarget assignments)	1	purified	No	GBAA1568	50196927	aspB	aspartate aminotransferase [Bacillus ant...	395	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J32	45.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02211 (show subtarget assignments)	1	cloned	No	CBU_2025	29542578	metC	cystathionine beta-lyase [Coxiella burne...	387	Conserved; Drug target functions	Phase 3: June 2008	3E6G	63%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02212 (show subtarget assignments)	1	cloned	No	CBU_2048	29542599	metE	5-methyltetrahydropteroyltriglutamate--h...	775	Conserved; Drug target functions	Phase 3: June 2008	1U1H	48.5%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01143 (show subtarget assignments)	1	in_pdb 3R8Y	No	BA_4194	30258698		2,3,4,5-tetrahydropyridine-2-carboxylate...	240	Drug Target Function	Phase 2: March 2008	3R8Y	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02201 (show subtarget assignments)	1	soluble	No	YPO0461	16120790	thrC	threonine synthase [Yersinia pestis CO92...	429	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1VB3	82.3%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP01849 (show subtarget assignments)	1	in_pdb 3L07	No	FTT0892	56707993	folD	methylenetetrahydrofolate dehydrogenase/...	282	Conserved; Drug target functions	Phase 3: June 2008	3L07	100%	Francisella tularensis	Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers	Aspartate familyFolic acid

IDP02323 (show subtarget assignments)	1	soluble	No	FTT0560c	56707690	serC	phosphoserine aminotransferase [Francise...	350	Drug Target	Phase 3: June 2008	3QBO	41.1%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism	Aspartate familyOther

IDP01832 (show subtarget assignments)	1	expressed	No	GBAA5547	47530867	atpD	F0F1 ATP synthase subunit beta [Bacillus...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	86.4%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02182 (show subtarget assignments)	1	cloned	No	FTT0065	56707244	atpC	F0F1 ATP synthase subunit epsilon [Franc...	145	Conserved; Drug target functions	Phase 3: June 2008	2QE7	33.1%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02177 (show subtarget assignments)	1	soluble	No	FTT0063	56707242	atpG	F0F1 ATP synthase subunit gamma [Francis...	298	Conserved; Drug target functions	Phase 3: June 2008	3OAA	49.7%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02389 (show subtarget assignments)	1	cloned	No	lmo0232	16802278	clpC	endopeptidase Clp ATP-binding chain C [L...	820	Known virulence-Invasion; PMID:11083831; Presence of Protease Motifs	Phase 3: June 2008	3PXI	72.8%	Listeria monocytogenes	Energy metabolism	ATP-proton motive force interconversion

IDP02648 (show subtarget assignments)	1	soluble	No	FTT0064	56707243	atpD	F0F1 ATP synthase subunit beta [Francise...	458	Conserved; Drug target functions	Phase 3: June 2008	3OAA	81.3%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02577 (show subtarget assignments)	1	purified	No	GBAA5546	47530866	atpC	F0F1 ATP synthase subunit epsilon [Bacil...	133	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E5Y	69.9%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP01802 (show subtarget assignments)	1	crystallized	No	FTT0062	56707241	atpA	F0F1 ATP synthase subunit alpha [Francis...	513	Conserved; Drug target functions	Phase 3: June 2008	3OAA	71%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP00450 (show subtarget assignments)	1	cloned	No	YPCD1.40	16082728	yscN	type III secretion system ATPase	439	Virulence Associated Factor	Phase 2: March 2008	2DPY	42.8%	Yersinia pestis	Energy metabolism	ATP-proton motive force interconversion

IDP00817 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2098	57286314	atpH	ATP synthase F1, delta subunit	179	Drug Target Function	Phase 2: March 2008	2WSS	21.2%	Staphylococcus aureus	Energy metabolism	ATP-proton motive force interconversion

IDP01821 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5549	47530869	atpA	F0F1 ATP synthase subunit alpha [Bacillu...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	84.5%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP01896 (show subtarget assignments)	1	soluble	No	STM0611	16763988		putative oxidoreductase protein [Salmone...	759	Conserved; Drug target functions	Phase 3: June 2008	1DMR	29.2%	Salmonella enterica	Energy metabolism	ATP-proton motive force interconversion

IDP01863 (show subtarget assignments)	1	cloned	No	GBAA5548	47778410	atpG	F0F1 ATP synthase subunit gamma [Bacillu...	286	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QE7	58.7%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02711 (show subtarget assignments)	1	cloned	No	GBAA5551	47530871	atpF	F0F1 ATP synthase subunit B [Bacillus an...	168	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP01933 (show subtarget assignments)	1	soluble	No	FTT0061	56707240	atpH	F0F1 ATP synthase subunit delta [Francis...	174	Conserved; Drug target functions	Phase 3: June 2008	2WSS	28.2%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP00577 (show subtarget assignments)	1	in_pdb 3OYT	Yes	YPO2757	16122961	fabB	3-oxoacyl-(acyl carrier protein) synthas...	407	Virulence Associated Factor	Phase 2: March 2008	3OYT	100%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04123 (show subtarget assignments)	1	expressed	No	YPO2768	115348451	accD	acetyl-coenzyme A carboxylase carboxyl t...	304	conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	84.5%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02782 (show subtarget assignments)	0	work_stopped	No	GBAA4874	161611196	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	252	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4F	94.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00116 (show subtarget assignments)	0	work_stopped	No	NT01ST0285	16763622	accA	acetylCoA carboxylase, carboxytransferas...	319	Essential	Phase 1: October 2007	2F9Y	96.9%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00541 (show subtarget assignments)	1	purified	No	YPO1597	16121865	fabH	3-oxoacyl-(acyl carrier protein) synthas...	316	Conserved Gene / Pathway	Phase 2: March 2008	1HN9	81.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01025 (show subtarget assignments)	1	cloned	No	STM1196	16764551	acpP	acyl carrier protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1L0H	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02130 (show subtarget assignments)	1	cloned	No	Cj1416c	15792734		putative sugar nucleotidyltransferase [C...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	25.7%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00532 (show subtarget assignments)	1	purified	No	YPO2390	16122613	cfa	cyclopropane fatty acyl phospholipid syn...	383	Virulence Associated Factor	Phase 2: March 2008	1TPY	25.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04082 (show subtarget assignments)	1	cloned	No	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00962 (show subtarget assignments)	1	cloned	No	STM1427	16764775	cfa	cyclopropane fatty acyl phospholipid syn...	382	Drug Target Function	Phase 2: March 2008	1KP9	26.7%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02407 (show subtarget assignments)	1	cloned	No	GBAA3988	47529279	acpP	acyl carrier protein [Bacillus anthracis...	77	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2X2B	81.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00956 (show subtarget assignments)	1	in_pdb 3H0P	No	STM1194	16764549	fabD	acyl carrier protein S-malonyltransferas...	309	potential drug target / Essential Gene	Phase 2: March 2008	3H0P	100%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00955 (show subtarget assignments)	1	cloned	No	STM1192	16764547	plsX	fatty acid/phospholipid synthesis protei...	359	Conserved Gene / Pathway	Phase 2: March 2008	1U7N	36.5%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02057 (show subtarget assignments)	1	soluble	No	Cj1311	15792634	neuA2	acylneuraminate cytidylyltransferase [Ca...	232	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	1QWJ	26.3%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00486 (show subtarget assignments)	1	expressed	No	YPO1463	16121738		putative acyl transferase	282	Conserved Gene / Pathway	Phase 2: March 2008	3RGI	47.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00485 (show subtarget assignments)	1	purified	No	YPO1455	16121730		putative beta-ketoacyl-[acyl-carrier-pro...	427	Drug Target Function	Phase 2: March 2008	1J3N	32.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00869 (show subtarget assignments)	1	cloned	No	STM4235	16767485	plsB	glycerol-3-phosphate acyltransferase	806	Essential Gene	Phase 2: March 2008			Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02748 (show subtarget assignments)	1	expressed	No	GBAA4408	47529702	accC	acetyl-CoA carboxylase biotin carboxylas...	450	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VPQ	66.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01493 (show subtarget assignments)	1	diffraction	No	VCA0751	161582040		3-oxoacyl-(acyl carrier protein) synthas...	362	Drug Target Function	Phase 2: March 2008	2EBD	40.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02328 (show subtarget assignments)	1	expressed	No	GBAA2548	47527837		acetyl-CoA carboxylase biotin carboxylas...	445	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N6R	51.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00816 (show subtarget assignments)	1	in_pdb 4DXE 3F09	Yes	SACOL2061	57284929	acpS	holo-(acyl-carrier-protein) synthase	119	Drug Target Function	Phase 2: March 2008	3F09	100%	Staphylococcus aureus	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04294 (show subtarget assignments)	1	cloned	No	YPO3477	115349102		putative lipid carrier protein [Yersinia...	173	conserved gene; putative drug target function;	Phase 4: April 2009	1C44	13.3%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00796 (show subtarget assignments)	0	work_stopped	No	SACOL1244	57285984	fabD	malonyl CoA-acyl carrier protein transac...	308	Drug Target Function	Phase 2: March 2008	3IM9	98.7%	Staphylococcus aureus	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00787 (show subtarget assignments)	0	work_stopped	No	SACOL1016	57284388	fabI	enoyl-(acyl carrier protein) reductase	256	Drug Target Function	Phase 2: March 2008	3GNS	100%	Staphylococcus aureus	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00426 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1598	16121866	fabD	acyl carrier protein S-malonyltransferas...	309	Conserved Gene / Pathway	Phase 2: March 2008	3H0P	79.3%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01461 (show subtarget assignments)	1	in_pdb 3H88	No	VC2457	15642453	acpS	4'-phosphopantetheinyl transferase	126	Drug Target Function	Phase 2: March 2008	3H88	100%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00407 (show subtarget assignments)	1	purified	No	YPO2929	16123116	acpS	4'-phosphopantetheinyl transferase	126	Virulence Associated Factor	Phase 2: March 2008	3H88	53.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04171 (show subtarget assignments)	1	cloned	No	VC2244	15642242		acetyl-CoA carboxylase carboxyltransfera...	319	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2F9Y	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00357 (show subtarget assignments)	1	expressed	No	lmo0885	16802926	acpS	hypothetical protein lmo0885	118	Drug Target Function	Phase 2: March 2008	1F7L	50%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00353 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2202	16804241		3-oxoacyl-(acyl carrier protein) synthas...	312	Drug Target Function	Phase 2: March 2008	1ZOW	58.1%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02724 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1330	47526596	fabG	acetoacetyl-CoA reductase [Bacillus anth...	247	Essential; Drug target functions	Phase 3: June 2008	2UVD	46.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00352 (show subtarget assignments)	1	purified	No	lmo1808	16803848	fabD	acyl-carrier-protein S-malonyltransferas...	313	Drug Target Function	Phase 2: March 2008	3IM9	46.6%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04726 (show subtarget assignments)	1	cloned	No	YPO1565	218928703		putative oxidoreductase [Yersinia pestis...	246	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2AG5	56.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02367 (show subtarget assignments)	1	soluble	No	GBAA0213	47525471		1-acyl-sn-glycerol-3-phosphate acyltrans...	201	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04714 (show subtarget assignments)	1	expressed	No	YPO0672	218927865	parF	putative acyltransferase [Yersinia pesti...	243	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00334 (show subtarget assignments)	1	in_pdb 3LYL	No	FTT1375	56708428	fabG	3-oxoacyl-(acyl-carrier-protein) reducta...	247	Drug Target Function	Phase 2: March 2008	3LYL	100%	Francisella tularensis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01781 (show subtarget assignments)	1	expressed	No	Cj1616	15792921	chuC	hemin ABC transporter, ATP-binding prote...	258	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	31.4%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01256 (show subtarget assignments)	0	work_stopped	No	BA_1232	30255181	fabI	enoyl-(acyl-carrier-protein) reductase	256	Drug Target Function	Phase 2: March 2008	2QIO	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01441 (show subtarget assignments)	1	in_crystallization_trials	No	VC2023	15642025		3-oxoacyl-(acyl carrier protein) synthas...	316	Drug Target Function	Phase 2: March 2008	1EBL	72.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01221 (show subtarget assignments)	1	expressed	No	BA_3990	30258499	fabD	malonyl CoA-acyl carrier protein transac...	314	Drug Target Function	Phase 2: March 2008	1MLA	44.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01440 (show subtarget assignments)	1	in_pdb 3HJV	No	VC2022	15642024		acyl carrier protein S-malonyltransferas...	312	Drug Target Function	Phase 2: March 2008	3HJV	100%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01214 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3460	30257999	cfa	cyclopropane-fatty-acyl-phospholipid syn...	390	Drug Target Function	Phase 2: March 2008	1TPY	25.1%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01213 (show subtarget assignments)	1	expressed	No	BA_3251	30257808		3-oxoacyl-(acyl-carrier-protein) synthas...	329	Drug Target Function	Phase 2: March 2008	2EBD	34.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00312 (show subtarget assignments)	1	expressed	No	CBU_0497	29653839	fabF	3-oxoacyl-acyl carrier protein synthase ...	414	Drug Target Function	Phase 2: March 2008	1B3N	60.1%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01201 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1826	34098434		3-oxoacyl-[acyl-carrier-protein] synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	40.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00311 (show subtarget assignments)	1	soluble	No	CBU_0494	29653836	fabD	malonyl CoA-acyl carrier protein transac...	313	Drug Target Function	Phase 2: March 2008	3TQE	100%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00571
(show subtarget assignments)

1

in_pdb
3GOS

No

YPO1041

16121341

dapD

2,3,4,5-tetrahydropyridine-2-carboxylate...

274

Virulence Associated Factor

Phase 2: March 2008

3GOS

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04122
(show subtarget assignments)

1

in_pdb
3OJC

Yes

YPO2758

115348441

putative aspartate/glutamate racemase [Y...

231

conserved gene; putative drug target function;

Phase 4: April 2009

3OJC

100%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01080
(show subtarget assignments)

0

work_stopped

No

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP02612
(show subtarget assignments)

0

work_stopped

No

GBAA5170

50196964

dapF

diaminopimelate epimerase [Bacillus anth...

288

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OTN

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02346
(show subtarget assignments)

1

cloned

No

GBAA2832

47528125

dapA-1

dihydrodipicolinate synthase [Bacillus a...

298

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NA8

34.2%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02783
(show subtarget assignments)

1

expressed

No

FTT0425c

56707572

asd

aspartate-semialdehyde dehydrogenase [Fr...

364

Conserved; Drug target functions

Phase 3: June 2008

1NWC

50%

Francisella tularensis

Amino acid biosynthesis

Aspartate family

IDP01610
(show subtarget assignments)

1

in_pdb
3I1I

No

GBAA4983

47778350

homoserine O-acetyltransferase [Bacillus...

374

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I1I

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01004
(show subtarget assignments)

1

in_pdb
3G0S

Yes

STM2489

16765809

dapA

dihydrodipicolinate synthase

292

Conserved Gene / Pathway

Phase 2: March 2008

3G0S

100%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP00998
(show subtarget assignments)

1

in_crystallization_trials

No

STM2369

16765696

usg

hypothetical protein STM2369

337

Conserved Gene / Pathway

Phase 2: March 2008

2QZ9

46.6%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP02093
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1970

47527265

thrB

homoserine kinase [Bacillus anthracis st...

297

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HUL

46.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02060
(show subtarget assignments)

1

expressed

No

CBU_1051

29541627

aspartate kinase [Coxiella burnetii RSA ...

409

Conserved; Drug target functions

Phase 3: June 2008

3AAW

45.1%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02042
(show subtarget assignments)

1

cloned

No

CBU_0875

29541467

asd

aspartate-semialdehyde dehydrogenase [Co...

340

Conserved; Drug target functions

Phase 3: June 2008

2QZ9

61.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02541
(show subtarget assignments)

1

expressed

No

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP00901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0004

16763394

thrC

threonine synthase

428

Conserved Gene / Pathway

Phase 2: March 2008

1VB3

93.5%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP00477
(show subtarget assignments)

1

purified

No

YPO3845

16123980

dapF

diaminopimelate epimerase

274

Conserved Gene / Pathway

Phase 2: March 2008

1GQZ

75.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04136
(show subtarget assignments)

1

diffraction

No

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP04457
(show subtarget assignments)

1

soluble

No

YPO1386

115347145

ansB

putative L-asparaginase II precursor [Ye...

345

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1NNS

71.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP00877
(show subtarget assignments)

1

crystallized

No

STM3015

16766317

ygeA

putative racemase

235

Conserved Gene / Pathway

Phase 2: March 2008

3OJC

56.6%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01785
(show subtarget assignments)

1

expressed

No

CBU_0667

29541271

dapD

2,3,4,5-tetrahydropyridine-2,6-dicarboxy...

271

Conserved; Drug target functions

Phase 3: June 2008

1KGQ

62.7%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04155
(show subtarget assignments)

1

cloned

No

VC0547

9654975

aspartokinase, alpha and beta subunits [...

395

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3L76

39.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP02380
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1969

47527264

thrC

threonine synthase [Bacillus anthracis s...

352

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZSJ

58%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP00434
(show subtarget assignments)

1

cloned

No

YPO0796

16121108

lysA

diaminopimelate decarboxylase

420

Drug Target Function

Phase 2: March 2008

1KNW

76.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04167
(show subtarget assignments)

1

cloned

No

VC1977

9656518

aspartate aminotransferase, putative [Vi...

404

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XI9

40.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP00088
(show subtarget assignments)

8

in_crystallization_trials

No

NT01ST3082

16421025

dapE

N-succinyl-diaminopimelate deacylase

375

Essential

Community Requests

3IC1

61.9%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP01731
(show subtarget assignments)

1

expressed

No

CBU_1222

29541792

dapA

dihydrodipicolinate synthase [Coxiella b...

289

Conserved; Drug target functions

Phase 3: June 2008

3QZE

55.2%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02487
(show subtarget assignments)

1

cloned

No

GBAA4218

47529511

metE

5-methyltetrahydropteroyltriglutamate--h...

762

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2NQ5

51.3%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01984
(show subtarget assignments)

1

expressed

No

CBU_0831

29541425

asnB-1

asparagine synthetase B, glutamine-hydro...

632

Conserved; Drug target functions

Phase 3: June 2008

1CT9

18.8%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02483
(show subtarget assignments)

1

cloned

No

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04704
(show subtarget assignments)

1

cloned

No

YPO0322

115346138

tyrB

aromatic-amino-acid aminotransferase [Ye...

397

conserved gene; putative drug target function;

Phase 4: April 2009

3TAT

75.6%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01701
(show subtarget assignments)

1

soluble

No

CBU_1970

29542525

dapF

diaminopimelate epimerase [Coxiella burn...

276

Conserved; Drug target functions

Phase 3: June 2008

1GQZ

48.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02467
(show subtarget assignments)

1

soluble

No

GBAA3937

47529228

asd-2

aspartate-semialdehyde dehydrogenase [Ba...

348

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GYY

60.6%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02636
(show subtarget assignments)

1

expressed

No

YPO3722

16123860

metH

B12-dependent methionine synthase [Yersi...

1231

CD; Drug target functions

Phase 3: June 2008

1K7Y

40.1%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP04501
(show subtarget assignments)

1

cloned

No

VC0991

9655452

asparagine synthetase B, glutamine-hydro...

554

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1CT9

75.3%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP02669
(show subtarget assignments)

1

purified

No

GBAA1568

50196927

aspB

aspartate aminotransferase [Bacillus ant...

395

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J32

45.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02211
(show subtarget assignments)

1

cloned

No

CBU_2025

29542578

metC

cystathionine beta-lyase [Coxiella burne...

387

Conserved; Drug target functions

Phase 3: June 2008

3E6G

63%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02212
(show subtarget assignments)

1

cloned

No

CBU_2048

29542599

metE

5-methyltetrahydropteroyltriglutamate--h...

775

Conserved; Drug target functions

Phase 3: June 2008

1U1H

48.5%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01143
(show subtarget assignments)

1

in_pdb
3R8Y

No

BA_4194

30258698

2,3,4,5-tetrahydropyridine-2-carboxylate...

240

Drug Target Function

Phase 2: March 2008

3R8Y

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02201
(show subtarget assignments)

1

soluble

No

YPO0461

16120790

thrC

threonine synthase [Yersinia pestis CO92...

429

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1VB3

82.3%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP01849
(show subtarget assignments)

1

in_pdb
3L07

No

FTT0892

56707993

folD

methylenetetrahydrofolate dehydrogenase/...

282

Conserved; Drug target functions

Phase 3: June 2008

3L07

100%

Francisella tularensis

Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers

Aspartate familyFolic acid

IDP02323
(show subtarget assignments)

1

soluble

No

FTT0560c

56707690

serC

phosphoserine aminotransferase [Francise...

350

Drug Target

Phase 3: June 2008

3QBO

41.1%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism

Aspartate familyOther

IDP01832
(show subtarget assignments)

1

expressed

No

GBAA5547

47530867

atpD

F0F1 ATP synthase subunit beta [Bacillus...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

86.4%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02182
(show subtarget assignments)

1

cloned

No

FTT0065

56707244

atpC

F0F1 ATP synthase subunit epsilon [Franc...

145

Conserved; Drug target functions

Phase 3: June 2008

2QE7

33.1%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02177
(show subtarget assignments)

1

soluble

No

FTT0063

56707242

atpG

F0F1 ATP synthase subunit gamma [Francis...

298

Conserved; Drug target functions

Phase 3: June 2008

3OAA

49.7%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02389
(show subtarget assignments)

1

cloned

No

lmo0232

16802278

clpC

endopeptidase Clp ATP-binding chain C [L...

820

Known virulence-Invasion; PMID:11083831; Presence of Protease Motifs

Phase 3: June 2008

3PXI

72.8%

Listeria monocytogenes

Energy metabolism

ATP-proton motive force interconversion

IDP02648
(show subtarget assignments)

1

soluble

No

FTT0064

56707243

atpD

F0F1 ATP synthase subunit beta [Francise...

458

Conserved; Drug target functions

Phase 3: June 2008

3OAA

81.3%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02577
(show subtarget assignments)

1

purified

No

GBAA5546

47530866

atpC

F0F1 ATP synthase subunit epsilon [Bacil...

133

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E5Y

69.9%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP01802
(show subtarget assignments)

1

crystallized

No

FTT0062

56707241

atpA

F0F1 ATP synthase subunit alpha [Francis...

513

Conserved; Drug target functions

Phase 3: June 2008

3OAA

71%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP00450
(show subtarget assignments)

1

cloned

No

YPCD1.40

16082728

yscN

type III secretion system ATPase

439

Virulence Associated Factor

Phase 2: March 2008

2DPY

42.8%

Yersinia pestis

Energy metabolism

ATP-proton motive force interconversion

IDP00817
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2098

57286314

atpH

ATP synthase F1, delta subunit

179

Drug Target Function

Phase 2: March 2008

2WSS

21.2%

Staphylococcus aureus

Energy metabolism

ATP-proton motive force interconversion

IDP01821
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5549

47530869

atpA

F0F1 ATP synthase subunit alpha [Bacillu...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

84.5%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP01896
(show subtarget assignments)

1

soluble

No

STM0611

16763988

putative oxidoreductase protein [Salmone...

759

Conserved; Drug target functions

Phase 3: June 2008

1DMR

29.2%

Salmonella enterica

Energy metabolism

ATP-proton motive force interconversion

IDP01863
(show subtarget assignments)

1

cloned

No

GBAA5548

47778410

atpG

F0F1 ATP synthase subunit gamma [Bacillu...

286

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QE7

58.7%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02711
(show subtarget assignments)

1

cloned

No

GBAA5551

47530871

atpF

F0F1 ATP synthase subunit B [Bacillus an...

168

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP01933
(show subtarget assignments)

1

soluble

No

FTT0061

56707240

atpH

F0F1 ATP synthase subunit delta [Francis...

174

Conserved; Drug target functions

Phase 3: June 2008

2WSS

28.2%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP00577
(show subtarget assignments)

1

in_pdb
3OYT

Yes

YPO2757

16122961

fabB

3-oxoacyl-(acyl carrier protein) synthas...

407

Virulence Associated Factor

Phase 2: March 2008

3OYT

100%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04123
(show subtarget assignments)

1

expressed

No

YPO2768

115348451

accD

acetyl-coenzyme A carboxylase carboxyl t...

304

conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

84.5%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02782
(show subtarget assignments)

0

work_stopped

No

GBAA4874

161611196

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

252

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4F

94.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00116
(show subtarget assignments)

0

work_stopped

No

NT01ST0285

16763622

accA

acetylCoA carboxylase, carboxytransferas...

319

Essential

Phase 1: October 2007

2F9Y

96.9%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00541
(show subtarget assignments)

1

purified

No

YPO1597

16121865

fabH

3-oxoacyl-(acyl carrier protein) synthas...

316

Conserved Gene / Pathway

Phase 2: March 2008

1HN9

81.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01025
(show subtarget assignments)

1

cloned

No

STM1196

16764551

acpP

acyl carrier protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1L0H

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02130
(show subtarget assignments)

1

cloned

No

Cj1416c

15792734

putative sugar nucleotidyltransferase [C...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

25.7%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00532
(show subtarget assignments)

1

purified

No

YPO2390

16122613

cfa

cyclopropane fatty acyl phospholipid syn...

383

Virulence Associated Factor

Phase 2: March 2008

1TPY

25.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04082
(show subtarget assignments)

1

cloned

No

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00962
(show subtarget assignments)

1

cloned

No

STM1427

16764775

cfa

cyclopropane fatty acyl phospholipid syn...

382

Drug Target Function

Phase 2: March 2008

1KP9

26.7%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02407
(show subtarget assignments)

1

cloned

No

GBAA3988

47529279

acpP

acyl carrier protein [Bacillus anthracis...

77

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2X2B

81.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00956
(show subtarget assignments)

1

in_pdb
3H0P

No

STM1194

16764549

fabD

acyl carrier protein S-malonyltransferas...

309

potential drug target / Essential Gene

Phase 2: March 2008

3H0P

100%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00955
(show subtarget assignments)

1

cloned

No

STM1192

16764547

plsX

fatty acid/phospholipid synthesis protei...

359

Conserved Gene / Pathway

Phase 2: March 2008

1U7N

36.5%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02057
(show subtarget assignments)

1

soluble

No

Cj1311

15792634

neuA2

acylneuraminate cytidylyltransferase [Ca...

232

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

1QWJ

26.3%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00486
(show subtarget assignments)

1

expressed

No

YPO1463

16121738

putative acyl transferase

282

Conserved Gene / Pathway

Phase 2: March 2008

3RGI

47.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00485
(show subtarget assignments)

1

purified

No

YPO1455

16121730

putative beta-ketoacyl-[acyl-carrier-pro...

427

Drug Target Function

Phase 2: March 2008

1J3N

32.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00869
(show subtarget assignments)

1

cloned

No

STM4235

16767485

plsB

glycerol-3-phosphate acyltransferase

806

Essential Gene

Phase 2: March 2008

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02748
(show subtarget assignments)

1

expressed

No

GBAA4408

47529702

accC

acetyl-CoA carboxylase biotin carboxylas...

450

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VPQ

66.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01493
(show subtarget assignments)

1

diffraction

No

VCA0751

161582040

3-oxoacyl-(acyl carrier protein) synthas...

362

Drug Target Function

Phase 2: March 2008

2EBD

40.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02328
(show subtarget assignments)

1

expressed

No

GBAA2548

47527837

acetyl-CoA carboxylase biotin carboxylas...

445

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N6R

51.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00816
(show subtarget assignments)

1

in_pdb
4DXE
3F09

Yes

SACOL2061

57284929

acpS

holo-(acyl-carrier-protein) synthase

119

Drug Target Function

Phase 2: March 2008

3F09

100%

Staphylococcus aureus

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04294
(show subtarget assignments)

1

cloned

No

YPO3477

115349102

putative lipid carrier protein [Yersinia...

173

conserved gene; putative drug target function;

Phase 4: April 2009

1C44

13.3%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00796
(show subtarget assignments)

0

work_stopped

No

SACOL1244

57285984

fabD

malonyl CoA-acyl carrier protein transac...

308

Drug Target Function

Phase 2: March 2008

3IM9

98.7%

Staphylococcus aureus

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00787
(show subtarget assignments)

0

work_stopped

No

SACOL1016

57284388

fabI

enoyl-(acyl carrier protein) reductase

256

Drug Target Function

Phase 2: March 2008

3GNS

100%

Staphylococcus aureus

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00426
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1598

16121866

fabD

acyl carrier protein S-malonyltransferas...

309

Conserved Gene / Pathway

Phase 2: March 2008

3H0P

79.3%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01461
(show subtarget assignments)

1

in_pdb
3H88

No

VC2457

15642453

acpS

4'-phosphopantetheinyl transferase

126

Drug Target Function

Phase 2: March 2008

3H88

100%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00407
(show subtarget assignments)

1

purified

No

YPO2929

16123116

acpS

4'-phosphopantetheinyl transferase

126

Virulence Associated Factor

Phase 2: March 2008

3H88

53.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04171
(show subtarget assignments)

1

cloned

No

VC2244

15642242

acetyl-CoA carboxylase carboxyltransfera...

319

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2F9Y

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00357
(show subtarget assignments)

1

expressed

No

lmo0885

16802926

acpS

hypothetical protein lmo0885

118

Drug Target Function

Phase 2: March 2008

1F7L

50%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00353
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2202

16804241

3-oxoacyl-(acyl carrier protein) synthas...

312

Drug Target Function

Phase 2: March 2008

1ZOW

58.1%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02724
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1330

47526596

fabG

acetoacetyl-CoA reductase [Bacillus anth...

247

Essential; Drug target functions

Phase 3: June 2008

2UVD

46.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00352
(show subtarget assignments)

1

purified

No

lmo1808

16803848

fabD

acyl-carrier-protein S-malonyltransferas...

313

Drug Target Function

Phase 2: March 2008

3IM9

46.6%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04726
(show subtarget assignments)

1

cloned

No

YPO1565

218928703

putative oxidoreductase [Yersinia pestis...

246

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2AG5

56.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02367
(show subtarget assignments)

1

soluble

No

GBAA0213

47525471

1-acyl-sn-glycerol-3-phosphate acyltrans...

201

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04714
(show subtarget assignments)

1

expressed

No

YPO0672

218927865

parF

putative acyltransferase [Yersinia pesti...

243

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00334
(show subtarget assignments)

1

in_pdb
3LYL

No

FTT1375

56708428

fabG

3-oxoacyl-(acyl-carrier-protein) reducta...

247

Drug Target Function

Phase 2: March 2008

3LYL

100%

Francisella tularensis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01781
(show subtarget assignments)

1

expressed

No

Cj1616

15792921

chuC

hemin ABC transporter, ATP-binding prote...

258

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

31.4%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01256
(show subtarget assignments)

0

work_stopped

No

BA_1232

30255181

fabI

enoyl-(acyl-carrier-protein) reductase

256

Drug Target Function

Phase 2: March 2008

2QIO

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01441
(show subtarget assignments)

1

in_crystallization_trials

No

VC2023

15642025

3-oxoacyl-(acyl carrier protein) synthas...

316

Drug Target Function

Phase 2: March 2008

1EBL

72.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01221
(show subtarget assignments)

1

expressed

No

BA_3990

30258499

fabD

malonyl CoA-acyl carrier protein transac...

314

Drug Target Function

Phase 2: March 2008

1MLA

44.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01440
(show subtarget assignments)

1

in_pdb
3HJV

No

VC2022

15642024

acyl carrier protein S-malonyltransferas...

312

Drug Target Function

Phase 2: March 2008

3HJV

100%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01214
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3460

30257999

cfa

cyclopropane-fatty-acyl-phospholipid syn...

390

Drug Target Function

Phase 2: March 2008

1TPY

25.1%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01213
(show subtarget assignments)

1

expressed

No

BA_3251

30257808

3-oxoacyl-(acyl-carrier-protein) synthas...

329

Drug Target Function

Phase 2: March 2008

2EBD

34.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00312
(show subtarget assignments)

1

expressed

No

CBU_0497

29653839

fabF

3-oxoacyl-acyl carrier protein synthase ...

414

Drug Target Function

Phase 2: March 2008

1B3N

60.1%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01201
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1826

34098434

3-oxoacyl-[acyl-carrier-protein] synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

40.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00311
(show subtarget assignments)

1

soluble

No

CBU_0494

29653836

fabD

malonyl CoA-acyl carrier protein transac...

313

Drug Target Function

Phase 2: March 2008

3TQE

100%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

Targets