Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05425 (show subtarget assignments)	1	soluble	No	lmo0355	16802400	-	fumarate reductase flavoprotein subunit ...	506	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1D4C	40.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05457 (show subtarget assignments)	1	soluble	No	BA_1144	30254865	gerPF1	spore germination protein GerPF [Bacillu...	71	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Sporulation and germination

IDP04311 (show subtarget assignments)	1	purified	No	BAS4340	49187335		50S ribosomal protein L27 [Bacillus anth...	96	Proposed to be essential proteins	Phase 4: April 2009	1VSA	55.2%	Bacillus anthracis

IDP04021 (show subtarget assignments)	1	expressed	No	BAS3695	49186694		30S ribosomal protein S16 [Bacillus anth...	90	Proposed to be essential proteins	Phase 4: April 2009	1EMW	42.2%	Bacillus anthracis

IDP05081 (show subtarget assignments)	1	expressed	No	lmo2027	16804066	-	putative cell surface protein, internali...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Y5Q	23.2%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP04730 (show subtarget assignments)	1	cloned	No	BAS4284	49187280		alanyl-tRNA synthetase [Bacillus anthrac...	880	Proposed to be essential proteins	Phase 4: April 2009	1RIQ	26.3%	Bacillus anthracis

IDP04026 (show subtarget assignments)	1	expressed	No	FTT0456c	56707598		hypothetical protein FTT_0456c [Francise...	97	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YHD	39.2%	Francisella tularensis

IDP04306 (show subtarget assignments)	8	selected	No	CAC05809	12329078	ipgE	IpgE, cytoplasmic chaperone for IpgD [Sh...	120	Shigella effector protein	Community Requests	1K3S	27.5%	Shigella flexneri

IDP05114 (show subtarget assignments)	1	cloned	No	CD2537	126700154		putative membrane-associated 5'-nucleoti...	605	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IVD	25.1%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05226 (show subtarget assignments)	1	cloned	No	lmo0460	16802504	-	putative membrane associated lipoprotein...	689	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3RGX	11.8%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP04310 (show subtarget assignments)	1	cloned	No	BAS0231	49183264		D-alanine--D-alanine ligase, C-terminus ...	91	Proposed to be essential proteins	Phase 4: April 2009	2I80	54.9%	Bacillus anthracis

IDP04307 (show subtarget assignments)	1	cloned	No	CPF_1812	110799901		putative lipoprotein [Clostridium perfri...	44	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens

IDP04022 (show subtarget assignments)	1	cloned	No	BAS0095	49183129		preprotein translocase subunit SecE [Bac...	59	Proposed to be essential proteins	Phase 4: April 2009	3DIN	33.9%	Bacillus anthracis

IDP05111 (show subtarget assignments)	1	cloned	No	CD2187	126699803		putative phage-related cell wall hydrola...	297	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	21.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05269 (show subtarget assignments)	1	soluble	No	lmo0517	16802560	-	hypothetical protein lmo0517 [Listeria m...	271	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3R7A	39.1%	Listeria monocytogenes	Energy metabolism: Glycolysis/gluconeogenesis

IDP05113 (show subtarget assignments)	1	in_pdb 4EGU	No	CD2447	126700064		histidine triad nucleotide-binding prote...	119	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	4EGU	100%	Clostridium difficile	Unknown function: General

IDP04308 (show subtarget assignments)	1	cloned	No	YPCD1.14n	40548797		hypothetical protein YPCD1.14n [Yersinia...	65	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04309 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0050	49183085		peptidyl-tRNA hydrolase [Bacillus anthra...	186	Proposed to be essential proteins	Phase 4: April 2009	3KJZ	40.9%	Bacillus anthracis

IDP05459 (show subtarget assignments)	1	cloned	No	BA_0873	30254623		conserved domain protein [Bacillus anthr...	231	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP05466 (show subtarget assignments)	1	soluble	No	BA_1948	30256606		putative lipoprotein [Bacillus anthracis...	148	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05176 (show subtarget assignments)	1	soluble	No	BA_2967	30257557		conserved domain protein [Bacillus anthr...	440	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP05117 (show subtarget assignments)	1	cloned	No	CD2831	126700447		putative collagen-binding protein [Clost...	972	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3KPT	9.3%	Clostridium difficile	Unknown function: General

IDP04069 (show subtarget assignments)	1	in_pdb 3R3T	Yes	BAS5327	49188311		30S ribosomal protein S6 [Bacillus anthr...	96	Proposed to be essential proteins	Phase 4: April 2009	3R3T	100%	Bacillus anthracis

IDP05119 (show subtarget assignments)	1	soluble	No	CD2989	126700610		ABC transporter, substrate-binding prote...	319	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X7P	23.5%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP05370 (show subtarget assignments)	1	cloned	No	BA_5220	30259701		putative ABC transporter, substrate-bind...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EF1	50.7%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP04314 (show subtarget assignments)	1	purified	No	YPCD1.73c	5832493	YPCD1.73c	hypothetical protein YPCD1.73c [Yersinia...	149	virulence factor; conserved gene;	Phase 4: April 2009	1JSC	40.7%	Yersinia pestis

IDP04339 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0115	49183149		50S ribosomal protein L22 [Bacillus anth...	113	Proposed to be essential proteins	Phase 4: April 2009	1BXE	59.3%	Bacillus anthracis

IDP04067 (show subtarget assignments)	1	purified	No	BAS4417	49187412		thioredoxin [Bacillus anthracis str. Ste...	104	Proposed to be essential proteins	Phase 4: April 2009	2GZY	75%	Bacillus anthracis

IDP05174 (show subtarget assignments)	1	cloned	No	BA_2570	30257192		conserved hypothetical protein [Bacillus...	245	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05116 (show subtarget assignments)	1	soluble	No	CD2542	126700159		hypothetical protein CD2542 [Clostridium...	402	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05024 (show subtarget assignments)	1	soluble	No	BAS4675	49187666	-	ABC transporter, substrate-binding prote...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	20.6%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP05175 (show subtarget assignments)	1	expressed	No	lmo1656	16803696	-	hypothetical protein lmo1656 [Listeria m...	143	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP05271 (show subtarget assignments)	1	cloned	No	lmo1194	16803234	cbiD	cobalt-precorrin-6A synthase [Listeria m...	373	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1SR8	23.1%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04728 (show subtarget assignments)	1	selected	No	BAS0102	49183136		DNA-directed RNA polymerase subunit beta...	1177	Proposed to be essential proteins	Phase 4: April 2009	1HQM	49.2%	Bacillus anthracis

IDP04327 (show subtarget assignments)	1	cloned	No	CPF_1243	110801193		sensory box histidine kinase [Clostridiu...	623	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	11.2%	Clostridium perfringens	Regulatory functions

IDP05295 (show subtarget assignments)	1	cloned	No	CD1816	126699424	cmk	cytidylate kinase [Clostridium difficile...	216	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Q3T	44.4%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP04068 (show subtarget assignments)	1	expressed	No	YPCD1.94n	40548799		hypothetical protein YPCD1.94n [Yersinia...	251	virulence factor;	Phase 4: April 2009	1A5V	15.1%	Yersinia pestis

IDP05293 (show subtarget assignments)	1	cloned	No	CD1408	126699011	ddl	D-alanine--D-alanine ligase [Clostridium...	299	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3R23	51.5%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04027 (show subtarget assignments)	1	cloned	No	BAS4637	49187628		leucyl-tRNA synthetase [Bacillus anthrac...	802	Proposed to be essential proteins	Phase 4: April 2009	1H3N	45.9%	Bacillus anthracis

IDP04326 (show subtarget assignments)	8	purified	No	CAC05800	12329069	ipaA	IpaA, secreted by the Mxi-Spa machinery,...	633	Shigella effector protein	Community Requests	2FM8	10.7%	Shigella flexneri

IDP05118 (show subtarget assignments)	1	cloned	No	Z5902	12519310		putative helicase [Escherichia coli O157...	704	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1PJR	12.8%	Escherichia coli	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05567 (show subtarget assignments)	1	soluble	No	lmo2576	16804614	-	pepdidoglycan bound protein [Listeria mo...	1530	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3KPT	7.5%	Listeria monocytogenes	Cell envelope: Other

IDP05464 (show subtarget assignments)	1	expressed	No	BA_1489	30255419		superoxide dismutase [Bacillus anthracis...	304	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1P7G	35.5%	Bacillus anthracis	Cellular processes: Detoxification

IDP04116 (show subtarget assignments)	1	expressed	No	Z5122	15804232	sepZ	hypothetical protein Z5122 [Escherichia ...	99	Effector protein	Phase 4: April 2009			Escherichia coli

IDP05566 (show subtarget assignments)	1	soluble	No	lmo2569	16804607	-	hypothetical protein lmo2569 [Listeria m...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3O9P	26.7%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Plasmid functions

IDP04066 (show subtarget assignments)	8	selected	No	CAC05819	12329088	mxiE	MxiE, similarities to transcriptional ac...	210	Shigella effector protein	Community Requests			Shigella flexneri

IDP04336 (show subtarget assignments)	8	in_crystallization_trials	No	CAC05790	12329059	ospC1	OspC1, secreted by the Mxi-Spa secretion...	470	Shigella effector protein	Community Requests			Shigella flexneri

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP05296 (show subtarget assignments)	1	purified	No	CD2138	126699755	pyrH	uridylate kinase [Clostridium difficile ...	234	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Z9D	59.1%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05294 (show subtarget assignments)	1	cloned	No	CD1418	126699021		putative drug/sodium antiporter [Clostri...	451	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3MKT	20.6%	Clostridium difficile	Transport and binding proteins: Other

IDP05281 (show subtarget assignments)	1	in_crystallization_trials	No	CD0136	126697708		PTS system, IIB component [Clostridium d...	108	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H9C	42.2%	Clostridium difficile	Signal transduction: PTS

IDP04074 (show subtarget assignments)	1	cloned	No	BAS4469	49187464		50S ribosomal protein L20 [Bacillus anth...	118	Proposed to be essential proteins	Phase 4: April 2009	1VS6	55.1%	Bacillus anthracis

IDP04075 (show subtarget assignments)	8	selected	No	CAC05807	12329076	icsB	IcsB, function unknown [Shigella flexner...	494	Shigella effector protein	Community Requests			Shigella flexneri

IDP05123 (show subtarget assignments)	1	soluble	No	BA_3845	30258363		conserved domain protein [Bacillus anthr...	310	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP05184 (show subtarget assignments)	1	purified	No	BA_5305	30259782		conserved domain protein [Bacillus anthr...	554	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP05042 (show subtarget assignments)	1	soluble	No	BA_2921	30257513		putative sulfonate ABC transporter, sulf...	328	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X26	28%	Bacillus anthracis	Transport and binding proteins: Anions

IDP05275 (show subtarget assignments)	1	soluble	No	lmo2686	16804723	-	hypothetical protein lmo2686 [Listeria m...	177	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP05027 (show subtarget assignments)	1	purified	No	BA_0231	30253731		putative oligopeptide ABC transporter, o...	555	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRF	27.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04350 (show subtarget assignments)	1	cloned	No	STM1338_1_795	16764689	pheT	phenylalanyl-tRNA synthetase subunit bet...	795	Salmonella essential protein	Phase 4: April 2009	3PCO	92.6%	Salmonella enterica

IDP05300 (show subtarget assignments)	1	cloned	No	VC_0631	9655066		tyrosyl-tRNA synthetase [Vibrio cholerae...	395	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H3E	47.8%	Vibrio cholerae	Protein synthesis: tRNA aminoacylation

IDP05003 (show subtarget assignments)	1	cloned	No	BA_3309	30257855		hypothetical protein BA_3309 [Bacillus a...	31	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP04380 (show subtarget assignments)	1	cloned	No	STM3713_1_404	16766998	rfaL	O-antigen ligase [Salmonella typhimurium...	404	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP05004 (show subtarget assignments)	1	cloned	No	CDP01	110666923		hypothetical protein CDP01 [Clostridium ...	33	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05299 (show subtarget assignments)	1	soluble	No	CD2524	126700141	nadD	nicotinate-nucleotide adenylyltransferas...	229	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KAM	34.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05084 (show subtarget assignments)	1	in_crystallization_trials	No	Z4803	12518085		putative ATP-dependent DNA helicase (tog...	202	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1OYW	33.7%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP04349 (show subtarget assignments)	1	expressed	No	STM0557_1_550	16763935		putative inner membrane protein [Salmone...	550	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP05303 (show subtarget assignments)	1	cloned	No	SACOL1685	57650511	aspS	aspartyl-tRNA synthetase [Staphylococcus...	588	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1C0A	54.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05387 (show subtarget assignments)	1	purified	No	BA_2041	30256692		putative oligopeptide ABC transporter, o...	553	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04732 (show subtarget assignments)	1	cloned	No	BAS5341	49188325		50S ribosomal protein L34 [Bacillus anth...	44	Proposed to be essential proteins	Phase 4: April 2009	1NKW	65.9%	Bacillus anthracis

IDP05181 (show subtarget assignments)	1	soluble	No	BA_4729	30259221		bacterial extracellular solute-binding p...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1UQW	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05599 (show subtarget assignments)	1	purified	No	BA_3642	30258168		putative oligopeptide ABC transporter, o...	568	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	28.9%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04034 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0128	49183162		50S ribosomal protein L30 [Bacillus anth...	60	Proposed to be essential proteins	Phase 4: April 2009	1VS6	53.3%	Bacillus anthracis

IDP05033 (show subtarget assignments)	1	cloned	No	BA_1260	30255209		hypothetical protein BA_1260 [Bacillus a...	34	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05130 (show subtarget assignments)	1	cloned	No	CD0119	126697691		phosphoglucomutase/phosphomannomutase mu...	454	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3PDK	50.2%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP05179 (show subtarget assignments)	1	soluble	No	BA_3367	30257910		LPXTG-motif cell wall anchor domain prot...	595	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05305 (show subtarget assignments)	1	cloned	No	CD2986	126700607	bacA2	undecaprenyl pyrophosphate phosphatase [...	283	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05180 (show subtarget assignments)	1	soluble	No	BA_3644	30258169		putative oligopeptide ABC transporter, o...	568	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TCF	29.6%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05222 (show subtarget assignments)	1	soluble	No	lmo0153	16802201	-	hypothetical protein lmo0153 [Listeria m...	313	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2O1E	52.1%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP05301 (show subtarget assignments)	1	in_pdb 3O04	No	lmo2201	16804240	-	hypothetical protein lmo2201 [Listeria m...	413	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3O04	99.8%	Listeria monocytogenes	Fatty acid and phospholipid metabolism: Biosynthesis

IDP05469 (show subtarget assignments)	1	soluble	No	BA_2398	30257029		putative lipoprotein [Bacillus anthracis...	177	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP04357 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0894	56707995	purCD	fusion protein PurC/PurD [Francisella tu...	770	conserved gene; putative drug target function;	Phase 4: April 2009	2YRW	20.3%	Francisella tularensis

IDP05409 (show subtarget assignments)	1	soluble	No	BA_2728	30257334		putative pullulanase [Bacillus anthracis...	852	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2WAN	37.2%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05472 (show subtarget assignments)	1	cloned	No	BA_2584	30257206		putative lipoprotein [Bacillus anthracis...	197	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05375 (show subtarget assignments)	1	expressed	No	BA_4118	30258624		hypothetical protein BA_4118 [Bacillus a...	57	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05223 (show subtarget assignments)	1	soluble	No	lmo0160	16802208	-	peptidoglycan binding protein [Listeria ...	565	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Y1V	19.5%	Listeria monocytogenes	Regulatory functions: Other

IDP04381 (show subtarget assignments)	8	selected	No	CAC05791	12329060		unnamed protein product [Shigella flexne...	296	Shigella effector protein	Community Requests	3MKL	8.4%	Shigella flexneri

IDP05183 (show subtarget assignments)	1	soluble	No	BA_5237	30259716		putative lipoprotein [Bacillus anthracis...	176	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05225 (show subtarget assignments)	1	cloned	No	lmo0415	16802459	-	hypothetical protein lmo0415 [Listeria m...	466	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	29%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05274 (show subtarget assignments)	1	soluble	No	lmo1880	16803919	-	hypothetical protein lmo1880 [Listeria m...	133	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JL2	33.8%	Listeria monocytogenes	Transcription: Degradation of RNA

IDP05029 (show subtarget assignments)	1	cloned	No	BA_0864	30254614		putative lipoprotein [Bacillus anthracis...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05028 (show subtarget assignments)	1	purified	No	BA_0331	30253869		polysaccharide deacetylase-like protein ...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: General

IDP04367 (show subtarget assignments)	1	cloned	No	BAS3563	49186564		PTS system, fructose-specific IIABC comp...	622	Proposed to be essential proteins	Phase 4: April 2009	2R4Q	11.4%	Bacillus anthracis

IDP05122 (show subtarget assignments)	1	expressed	No	BA_3551	30258083	amyS	alpha-amylase [Bacillus anthracis str. A...	513	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VJS	68.6%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05224 (show subtarget assignments)	1	cloned	No	VC_0595	9655026		glutamyl-tRNA synthetase-related protein...	304	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	55.3%	Vibrio cholerae	Unknown function: General

IDP05429 (show subtarget assignments)	1	cloned	No	lmo0791	16802833	-	hypothetical protein lmo0791 [Listeria m...	216	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP05002 (show subtarget assignments)	1	cloned	No	lmo0086	16802134	-	hypothetical protein lmo0086 [Listeria m...	1959	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TUF	2.8%	Listeria monocytogenes

IDP05032 (show subtarget assignments)	1	cloned	No	BA_1198	30255151		hypothetical protein BA_1198 [Bacillus a...	47	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05478 (show subtarget assignments)	1	cloned	No	BA_2933	30257525		putative lipoprotein [Bacillus anthracis...	203	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP91272 (show subtarget assignments)	8	cloned	No	NT05BA3926	49180681		RNA polymerase sigma-29 factor [Bacillus...	239	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L0O	31.4%	Bacillus anthracis

IDP91271 (show subtarget assignments)	8	expressed	No	NT05BA3690	49180451		prophage LambdaBa01, positive control fa...	167	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP05425
(show subtarget assignments)

1

soluble

No

lmo0355

16802400

-

fumarate reductase flavoprotein subunit ...

506

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1D4C

40.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05457
(show subtarget assignments)

1

soluble

No

BA_1144

30254865

gerPF1

spore germination protein GerPF [Bacillu...

71

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP04311
(show subtarget assignments)

1

purified

No

BAS4340

49187335

50S ribosomal protein L27 [Bacillus anth...

96

Proposed to be essential proteins

Phase 4: April 2009

1VSA

55.2%

Bacillus anthracis

IDP04021
(show subtarget assignments)

1

expressed

No

BAS3695

49186694

30S ribosomal protein S16 [Bacillus anth...

90

Proposed to be essential proteins

Phase 4: April 2009

1EMW

42.2%

Bacillus anthracis

IDP05081
(show subtarget assignments)

1

expressed

No

lmo2027

16804066

-

putative cell surface protein, internali...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Y5Q

23.2%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP04730
(show subtarget assignments)

1

cloned

No

BAS4284

49187280

alanyl-tRNA synthetase [Bacillus anthrac...

880

Proposed to be essential proteins

Phase 4: April 2009

1RIQ

26.3%

Bacillus anthracis

IDP04026
(show subtarget assignments)

1

expressed

No

FTT0456c

56707598

hypothetical protein FTT_0456c [Francise...

97

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YHD

39.2%

Francisella tularensis

IDP04306
(show subtarget assignments)

8

selected

No

CAC05809

12329078

ipgE

IpgE, cytoplasmic chaperone for IpgD [Sh...

120

Shigella effector protein

Community Requests

1K3S

27.5%

Shigella flexneri

IDP05114
(show subtarget assignments)

1

cloned

No

CD2537

126700154

putative membrane-associated 5'-nucleoti...

605

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IVD

25.1%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05226
(show subtarget assignments)

1

cloned

No

lmo0460

16802504

-

putative membrane associated lipoprotein...

689

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3RGX

11.8%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP04310
(show subtarget assignments)

1

cloned

No

BAS0231

49183264

D-alanine--D-alanine ligase, C-terminus ...

91

Proposed to be essential proteins

Phase 4: April 2009

2I80

54.9%

Bacillus anthracis

IDP04307
(show subtarget assignments)

1

cloned

No

CPF_1812

110799901

putative lipoprotein [Clostridium perfri...

44

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

IDP04022
(show subtarget assignments)

1

cloned

No

BAS0095

49183129

preprotein translocase subunit SecE [Bac...

59

Proposed to be essential proteins

Phase 4: April 2009

3DIN

33.9%

Bacillus anthracis

IDP05111
(show subtarget assignments)

1

cloned

No

CD2187

126699803

putative phage-related cell wall hydrola...

297

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

21.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05269
(show subtarget assignments)

1

soluble

No

lmo0517

16802560

-

hypothetical protein lmo0517 [Listeria m...

271

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3R7A

39.1%

Listeria monocytogenes

Energy metabolism: Glycolysis/gluconeogenesis

IDP05113
(show subtarget assignments)

1

in_pdb
4EGU

No

CD2447

126700064

histidine triad nucleotide-binding prote...

119

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

4EGU

100%

Clostridium difficile

Unknown function: General

IDP04308
(show subtarget assignments)

1

cloned

No

YPCD1.14n

40548797

hypothetical protein YPCD1.14n [Yersinia...

65

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04309
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0050

49183085

peptidyl-tRNA hydrolase [Bacillus anthra...

186

Proposed to be essential proteins

Phase 4: April 2009

3KJZ

40.9%

Bacillus anthracis

IDP05459
(show subtarget assignments)

1

cloned

No

BA_0873

30254623

conserved domain protein [Bacillus anthr...

231

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP05466
(show subtarget assignments)

1

soluble

No

BA_1948

30256606

putative lipoprotein [Bacillus anthracis...

148

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05176
(show subtarget assignments)

1

soluble

No

BA_2967

30257557

conserved domain protein [Bacillus anthr...

440

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP05117
(show subtarget assignments)

1

cloned

No

CD2831

126700447

putative collagen-binding protein [Clost...

972

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3KPT

9.3%

Clostridium difficile

Unknown function: General

IDP04069
(show subtarget assignments)

1

in_pdb
3R3T

Yes

BAS5327

49188311

30S ribosomal protein S6 [Bacillus anthr...

96

Proposed to be essential proteins

Phase 4: April 2009

3R3T

100%

Bacillus anthracis

IDP05119
(show subtarget assignments)

1

soluble

No

CD2989

126700610

ABC transporter, substrate-binding prote...

319

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X7P

23.5%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP05370
(show subtarget assignments)

1

cloned

No

BA_5220

30259701

putative ABC transporter, substrate-bind...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EF1

50.7%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP04314
(show subtarget assignments)

1

purified

No

YPCD1.73c

5832493

YPCD1.73c

hypothetical protein YPCD1.73c [Yersinia...

149

virulence factor; conserved gene;

Phase 4: April 2009

1JSC

40.7%

Yersinia pestis

IDP04339
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0115

49183149

50S ribosomal protein L22 [Bacillus anth...

113

Proposed to be essential proteins

Phase 4: April 2009

1BXE

59.3%

Bacillus anthracis

IDP04067
(show subtarget assignments)

1

purified

No

BAS4417

49187412

thioredoxin [Bacillus anthracis str. Ste...

104

Proposed to be essential proteins

Phase 4: April 2009

2GZY

75%

Bacillus anthracis

IDP05174
(show subtarget assignments)

1

cloned

No

BA_2570

30257192

conserved hypothetical protein [Bacillus...

245

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05116
(show subtarget assignments)

1

soluble

No

CD2542

126700159

hypothetical protein CD2542 [Clostridium...

402

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05024
(show subtarget assignments)

1

soluble

No

BAS4675

49187666

-

ABC transporter, substrate-binding prote...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

20.6%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP05175
(show subtarget assignments)

1

expressed

No

lmo1656

16803696

-

hypothetical protein lmo1656 [Listeria m...

143

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP05271
(show subtarget assignments)

1

cloned

No

lmo1194

16803234

cbiD

cobalt-precorrin-6A synthase [Listeria m...

373

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1SR8

23.1%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04728
(show subtarget assignments)

1

selected

No

BAS0102

49183136

DNA-directed RNA polymerase subunit beta...

1177

Proposed to be essential proteins

Phase 4: April 2009

1HQM

49.2%

Bacillus anthracis

IDP04327
(show subtarget assignments)

1

cloned

No

CPF_1243

110801193

sensory box histidine kinase [Clostridiu...

623

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

11.2%

Clostridium perfringens

Regulatory functions

IDP05295
(show subtarget assignments)

1

cloned

No

CD1816

126699424

cmk

cytidylate kinase [Clostridium difficile...

216

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Q3T

44.4%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP04068
(show subtarget assignments)

1

expressed

No

YPCD1.94n

40548799

hypothetical protein YPCD1.94n [Yersinia...

251

virulence factor;

Phase 4: April 2009

1A5V

15.1%

Yersinia pestis

IDP05293
(show subtarget assignments)

1

cloned

No

CD1408

126699011

ddl

D-alanine--D-alanine ligase [Clostridium...

299

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3R23

51.5%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04027
(show subtarget assignments)

1

cloned

No

BAS4637

49187628

leucyl-tRNA synthetase [Bacillus anthrac...

802

Proposed to be essential proteins

Phase 4: April 2009

1H3N

45.9%

Bacillus anthracis

IDP04326
(show subtarget assignments)

8

purified

No

CAC05800

12329069

ipaA

IpaA, secreted by the Mxi-Spa machinery,...

633

Shigella effector protein

Community Requests

2FM8

10.7%

Shigella flexneri

IDP05118
(show subtarget assignments)

1

cloned

No

Z5902

12519310

putative helicase [Escherichia coli O157...

704

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1PJR

12.8%

Escherichia coli

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP05567
(show subtarget assignments)

1

soluble

No

lmo2576

16804614

-

pepdidoglycan bound protein [Listeria mo...

1530

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3KPT

7.5%

Listeria monocytogenes

Cell envelope: Other

IDP05464
(show subtarget assignments)

1

expressed

No

BA_1489

30255419

superoxide dismutase [Bacillus anthracis...

304

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1P7G

35.5%

Bacillus anthracis

Cellular processes: Detoxification

IDP04116
(show subtarget assignments)

1

expressed

No

Z5122

15804232

sepZ

hypothetical protein Z5122 [Escherichia ...

99

Effector protein

Phase 4: April 2009

Escherichia coli

IDP05566
(show subtarget assignments)

1

soluble

No

lmo2569

16804607

-

hypothetical protein lmo2569 [Listeria m...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3O9P

26.7%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Plasmid functions

IDP04066
(show subtarget assignments)

8

selected

No

CAC05819

12329088

mxiE

MxiE, similarities to transcriptional ac...

210

Shigella effector protein

Community Requests

Shigella flexneri

IDP04336
(show subtarget assignments)

8

in_crystallization_trials

No

CAC05790

12329059

ospC1

OspC1, secreted by the Mxi-Spa secretion...

470

Shigella effector protein

Community Requests

Shigella flexneri

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP05296
(show subtarget assignments)

1

purified

No

CD2138

126699755

pyrH

uridylate kinase [Clostridium difficile ...

234

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Z9D

59.1%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05294
(show subtarget assignments)

1

cloned

No

CD1418

126699021

putative drug/sodium antiporter [Clostri...

451

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3MKT

20.6%

Clostridium difficile

Transport and binding proteins: Other

IDP05281
(show subtarget assignments)

1

in_crystallization_trials

No

CD0136

126697708

PTS system, IIB component [Clostridium d...

108

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H9C

42.2%

Clostridium difficile

Signal transduction: PTS

IDP04074
(show subtarget assignments)

1

cloned

No

BAS4469

49187464

50S ribosomal protein L20 [Bacillus anth...

118

Proposed to be essential proteins

Phase 4: April 2009

1VS6

55.1%

Bacillus anthracis

IDP04075
(show subtarget assignments)

8

selected

No

CAC05807

12329076

icsB

IcsB, function unknown [Shigella flexner...

494

Shigella effector protein

Community Requests

Shigella flexneri

IDP05123
(show subtarget assignments)

1

soluble

No

BA_3845

30258363

conserved domain protein [Bacillus anthr...

310

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP05184
(show subtarget assignments)

1

purified

No

BA_5305

30259782

conserved domain protein [Bacillus anthr...

554

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP05042
(show subtarget assignments)

1

soluble

No

BA_2921

30257513

putative sulfonate ABC transporter, sulf...

328

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X26

28%

Bacillus anthracis

Transport and binding proteins: Anions

IDP05275
(show subtarget assignments)

1

soluble

No

lmo2686

16804723

-

hypothetical protein lmo2686 [Listeria m...

177

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP05027
(show subtarget assignments)

1

purified

No

BA_0231

30253731

putative oligopeptide ABC transporter, o...

555

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRF

27.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04350
(show subtarget assignments)

1

cloned

No

STM1338_1_795

16764689

pheT

phenylalanyl-tRNA synthetase subunit bet...

795

Salmonella essential protein

Phase 4: April 2009

3PCO

92.6%

Salmonella enterica

IDP05300
(show subtarget assignments)

1

cloned

No

VC_0631

9655066

tyrosyl-tRNA synthetase [Vibrio cholerae...

395

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H3E

47.8%

Vibrio cholerae

Protein synthesis: tRNA aminoacylation

IDP05003
(show subtarget assignments)

1

cloned

No

BA_3309

30257855

hypothetical protein BA_3309 [Bacillus a...

31

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP04380
(show subtarget assignments)

1

cloned

No

STM3713_1_404

16766998

rfaL

O-antigen ligase [Salmonella typhimurium...

404

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP05004
(show subtarget assignments)

1

cloned

No

CDP01

110666923

hypothetical protein CDP01 [Clostridium ...

33

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05299
(show subtarget assignments)

1

soluble

No

CD2524

126700141

nadD

nicotinate-nucleotide adenylyltransferas...

229

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KAM

34.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05084
(show subtarget assignments)

1

in_crystallization_trials

No

Z4803

12518085

putative ATP-dependent DNA helicase (tog...

202

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1OYW

33.7%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP04349
(show subtarget assignments)

1

expressed

No

STM0557_1_550

16763935

putative inner membrane protein [Salmone...

550

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP05303
(show subtarget assignments)

1

cloned

No

SACOL1685

57650511

aspS

aspartyl-tRNA synthetase [Staphylococcus...

588

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1C0A

54.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05387
(show subtarget assignments)

1

purified

No

BA_2041

30256692

putative oligopeptide ABC transporter, o...

553

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04732
(show subtarget assignments)

1

cloned

No

BAS5341

49188325

50S ribosomal protein L34 [Bacillus anth...

44

Proposed to be essential proteins

Phase 4: April 2009

1NKW

65.9%

Bacillus anthracis

IDP05181
(show subtarget assignments)

1

soluble

No

BA_4729

30259221

bacterial extracellular solute-binding p...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1UQW

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05599
(show subtarget assignments)

1

purified

No

BA_3642

30258168

putative oligopeptide ABC transporter, o...

568

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

28.9%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04034
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0128

49183162

50S ribosomal protein L30 [Bacillus anth...

60

Proposed to be essential proteins

Phase 4: April 2009

1VS6

53.3%

Bacillus anthracis

IDP05033
(show subtarget assignments)

1

cloned

No

BA_1260

30255209

hypothetical protein BA_1260 [Bacillus a...

34

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05130
(show subtarget assignments)

1

cloned

No

CD0119

126697691

phosphoglucomutase/phosphomannomutase mu...

454

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3PDK

50.2%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP05179
(show subtarget assignments)

1

soluble

No

BA_3367

30257910

LPXTG-motif cell wall anchor domain prot...

595

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05305
(show subtarget assignments)

1

cloned

No

CD2986

126700607

bacA2

undecaprenyl pyrophosphate phosphatase [...

283

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05180
(show subtarget assignments)

1

soluble

No

BA_3644

30258169

putative oligopeptide ABC transporter, o...

568

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TCF

29.6%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05222
(show subtarget assignments)

1

soluble

No

lmo0153

16802201

-

hypothetical protein lmo0153 [Listeria m...

313

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2O1E

52.1%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP05301
(show subtarget assignments)

1

in_pdb
3O04

No

lmo2201

16804240

-

hypothetical protein lmo2201 [Listeria m...

413

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3O04

99.8%

Listeria monocytogenes

Fatty acid and phospholipid metabolism: Biosynthesis

IDP05469
(show subtarget assignments)

1

soluble

No

BA_2398

30257029

putative lipoprotein [Bacillus anthracis...

177

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP04357
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0894

56707995

purCD

fusion protein PurC/PurD [Francisella tu...

770

conserved gene; putative drug target function;

Phase 4: April 2009

2YRW

20.3%

Francisella tularensis

IDP05409
(show subtarget assignments)

1

soluble

No

BA_2728

30257334

putative pullulanase [Bacillus anthracis...

852

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2WAN

37.2%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05472
(show subtarget assignments)

1

cloned

No

BA_2584

30257206

putative lipoprotein [Bacillus anthracis...

197

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05375
(show subtarget assignments)

1

expressed

No

BA_4118

30258624

hypothetical protein BA_4118 [Bacillus a...

57

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05223
(show subtarget assignments)

1

soluble

No

lmo0160

16802208

-

peptidoglycan binding protein [Listeria ...

565

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Y1V

19.5%

Listeria monocytogenes

Regulatory functions: Other

IDP04381
(show subtarget assignments)

8

selected

No

CAC05791

12329060

unnamed protein product [Shigella flexne...

296

Shigella effector protein

Community Requests

3MKL

8.4%

Shigella flexneri

IDP05183
(show subtarget assignments)

1

soluble

No

BA_5237

30259716

putative lipoprotein [Bacillus anthracis...

176

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05225
(show subtarget assignments)

1

cloned

No

lmo0415

16802459

-

hypothetical protein lmo0415 [Listeria m...

466

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

29%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05274
(show subtarget assignments)

1

soluble

No

lmo1880

16803919

-

hypothetical protein lmo1880 [Listeria m...

133

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JL2

33.8%

Listeria monocytogenes

Transcription: Degradation of RNA

IDP05029
(show subtarget assignments)

1

cloned

No

BA_0864

30254614

putative lipoprotein [Bacillus anthracis...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05028
(show subtarget assignments)

1

purified

No

BA_0331

30253869

polysaccharide deacetylase-like protein ...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: General

IDP04367
(show subtarget assignments)

1

cloned

No

BAS3563

49186564

PTS system, fructose-specific IIABC comp...

622

Proposed to be essential proteins

Phase 4: April 2009

2R4Q

11.4%

Bacillus anthracis

IDP05122
(show subtarget assignments)

1

expressed

No

BA_3551

30258083

amyS

alpha-amylase [Bacillus anthracis str. A...

513

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VJS

68.6%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05224
(show subtarget assignments)

1

cloned

No

VC_0595

9655026

glutamyl-tRNA synthetase-related protein...

304

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

55.3%

Vibrio cholerae

Unknown function: General

IDP05429
(show subtarget assignments)

1

cloned

No

lmo0791

16802833

-

hypothetical protein lmo0791 [Listeria m...

216

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP05002
(show subtarget assignments)

1

cloned

No

lmo0086

16802134

-

hypothetical protein lmo0086 [Listeria m...

1959

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TUF

2.8%

Listeria monocytogenes

IDP05032
(show subtarget assignments)

1

cloned

No

BA_1198

30255151

hypothetical protein BA_1198 [Bacillus a...

47

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05478
(show subtarget assignments)

1

cloned

No

BA_2933

30257525

putative lipoprotein [Bacillus anthracis...

203

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP91272
(show subtarget assignments)

8

cloned

No

NT05BA3926

49180681

RNA polymerase sigma-29 factor [Bacillus...

239

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L0O

31.4%

Bacillus anthracis

IDP91271
(show subtarget assignments)

8

expressed

No

NT05BA3690

49180451

prophage LambdaBa01, positive control fa...

167

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair