Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91326 (show subtarget assignments)	8	soluble	No	VV2_0291	27366737		chaperonin GroEL [Vibrio vulnificus CMCP...	210	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP02422 (show subtarget assignments)	1	cloned	No	YPO1666	16121930	cheA	chemotaxis protein CheA [Yersinia pestis...	723	Conserved; CD; Drug target functions	Phase 3: June 2008	1B3Q	22.7%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP05056 (show subtarget assignments)	1	soluble	No	CD0257	126697829	motB	chemotaxis protein [Clostridium difficil...	231	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2K1S	20.3%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05091 (show subtarget assignments)	1	cloned	No	CD0256	126697828	motA	chemotaxis protein [Clostridium difficil...	272	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP01029 (show subtarget assignments)	0	work_stopped	No	STM1916	16765258	cheY	chemotaxis regulator transmitting signal...	129	Conserved Gene / Pathway	Phase 2: March 2008	2FKA	100%	Salmonella enterica	Cellular processes	Other

IDP02322 (show subtarget assignments)	1	soluble	No	lmo0691	16802733	cheY	chemotaxis response regulator CheY [List...	119	Known virulence-Regulation; PMID:15155625	Phase 3: June 2008	1TMY	63.9%	Listeria monocytogenes	Regulatory functions	Other

IDP01934 (show subtarget assignments)	1	soluble	No	GBAA0385	47525656		chitinase B [Bacillus anthracis str. 'Am...	674	Drug target motif; Drug target functions	Phase 3: June 2008	1ITX	37.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00041 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2409	30257040		chloramphenicol acetyltransferase	216	Virulence	Phase 1: October 2007	1QCA	41.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01350 (show subtarget assignments)	1	in_pdb 3EEV	No	VCA0300	15601065		chloramphenicol acetyltransferase	209	Drug Target Function	Phase 2: March 2008	3EEV	100%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP90337 (show subtarget assignments)	8	expressed	No	CT_623	6578109		CHLPN 76kDa Homolog [Chlamydia trachomat...	432	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90413 (show subtarget assignments)	8	cloned	No	CT_622	3329069		CHLPN 76kDa Homolog [Chlamydia trachomat...	647	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90419 (show subtarget assignments)	8	cloned	No	CT_446	3328878	euo	CHLPS Euo Protein [Chlamydia trachomatis...	183	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90371 (show subtarget assignments)	8	cloned	No	CT_109	3328506		CHLPS hypothetical protein [Chlamydia tr...	262	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90397 (show subtarget assignments)	8	in_crystallization_trials	No	CT_583	3329026	gp6D	CHLTR Plasmid Paralog [Chlamydia trachom...	263	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90315 (show subtarget assignments)	8	cloned	No	CT_744	3329204		CHLTR possible phosphoprotein [Chlamydia...	821	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00142 (show subtarget assignments)	1	cloned	No	VC1456	15641467	ctxB	cholera enterotoxin, B subunit	124	Virulence	Phase 1: October 2007	1EEI	81.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP91914 (show subtarget assignments)	8	selected	No	SpneCMD_010100003195	298229663		choline binding protein D [Streptococcus...	448	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2V04	14.3%	Streptococcus pneumoniae

IDP91919 (show subtarget assignments)	8	selected	No	SpneCM_010100003360	298254637		choline binding protein G [Streptococcus...	197	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P3C	24.9%	Streptococcus pneumoniae

IDP91974 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100003435	298254652		choline binding protein J [Streptococcus...	332	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2VYU	58.2%	Streptococcus pneumoniae

IDP91921 (show subtarget assignments)	8	selected	No	SpneCM_010100000547	298254088		choline binding protein PcpA, partial [S...	222	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2V04	44.6%	Streptococcus pneumoniae

IDP00833 (show subtarget assignments)	1	cloned	No	SACOL2627	57286532	betA	choline dehydrogenase	569	Conserved Gene / Pathway	Phase 2: March 2008	3LJP	32.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00056 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3898	30258412		choloylglycine hydrolase family protein ...	328	Virulence	Phase 1: October 2007	2OQC	48.8%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP91298 (show subtarget assignments)	8	cloned	No	STM1269	16764620	-	chorismate mutase	181	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2GBB	27.6%	Salmonella enterica

IDP01211 (show subtarget assignments)	1	crystallized	No	BA_2958	30257549		chorismate mutase/phospho-2-dehydro-3-de...	358	Drug Target Function	Phase 2: March 2008	3NVT	69.8%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP91304 (show subtarget assignments)	8	soluble	No	STM2667	16765982	pheA	chorismate mutase P/prephenate dehydrata...	386	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1ECM	25.1%	Salmonella enterica

IDP90772 (show subtarget assignments)	8	soluble	No	Cj0316	15791684	pheA	chorismate mutase/prephenate dehydratase...	357	Predicted Essential	Community Requests	3MWB	27.5%	Campylobacter jejuni

IDP00319 (show subtarget assignments)	1	expressed	No	CBU_2070	29655348		chorismate mutase, putative	136	Drug Target Function	Phase 2: March 2008			Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02059 (show subtarget assignments)	1	expressed	No	YPO1353	16121633		chorismate mutase [Yersinia pestis CO92]...	186	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2GBB	83.9%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP02012 (show subtarget assignments)	1	soluble	No	STM4233	16767483	ubiC	chorismate pyruvate lyase [Salmonella ty...	165	Conserved; Drug target functions	Phase 3: June 2008	1G1B	86.1%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90584 (show subtarget assignments)	8	purified	No	VC0095	15640127		chorismate--pyruvate lyase [Vibrio chole...	183	Predicted Essential	Community Requests	1FW9	28.4%	Vibrio cholerae

IDP90522 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0310	16120648	ubiC	chorismate pyruvate lyase [Yersinia pest...	174	Predicted Essential	Community Requests	1G1B	50.6%	Yersinia pestis

IDP91303 (show subtarget assignments)	8	soluble	No	STM2384	16765711	aroC	chorismate synthase	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1SQ1	45.7%	Salmonella enterica

IDP00539 (show subtarget assignments)	1	purified	No	YPO2751	16122955	aroC	chorismate synthase	361	Conserved Gene / Pathway	Phase 2: March 2008	1R52	45%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP00338 (show subtarget assignments)	1	cloned	No	FTT0876c	56707980	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1UM0	47.4%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00327 (show subtarget assignments)	0	work_stopped	No	Cj1634c	15792939	aroC	chorismate synthase	362	Drug Target Function	Phase 2: March 2008	1SQ1	100%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00315 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0874	29654200	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1R52	44.7%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01199 (show subtarget assignments)	1	purified	No	BA_1537	67460530		Chorismate synthase 1 (5-enolpyruvylshik...	390	Drug Target Function	Phase 2: March 2008	1QXO	59%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP90161 (show subtarget assignments)	8	purified	No	CD1835	123174273		Chorismate synthase (5-enolpyruvylshikim...	359	Potential drug target. Shikimate pathway enzyme	Community Requests	1UM0	38.7%	Clostridium difficile

IDP91209 (show subtarget assignments)	8	expressed	No	BT_2084	29347494		chorismate synthase [Bacteroides thetaio...	358	potential drug target / Shikimate pathway enzyme	Community Requests	1R52	47.9%	Bacteroides thetaiotaomicron

IDP91213 (show subtarget assignments)	8	in_pdb 4ECD	No	Blon_1598	189439475	aroC	chorismate synthase [Bifidobacterium lon...	395	potential drug target / Shikimate pathway enzyme	Community Requests	4ECD	100%	Bifidobacterium longum

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP91230 (show subtarget assignments)	8	soluble	No	NT04EC2956	26109123	aroC	Chorismate synthase [Escherichia coli CF...	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1SQ1	46.5%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP05341 (show subtarget assignments)	1	cloned	No	lmo1928	16803967	aroF	chorismate synthase [Listeria monocytoge...	388	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1QXO	63.1%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP92110 (show subtarget assignments)	8	selected	No	TGME49_001380	237836313		chorismate synthase, putative [Toxoplasm...	536	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1R52	36.9%	Toxoplasma gondii

IDP91285 (show subtarget assignments)	8	soluble	No	SPA0480	56412719	aroC	chorismate synthase [Salmonella enterica...	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1R52	45.7%	Salmonella enterica

IDP91284 (show subtarget assignments)	8	cloned	No	SF2405	56480091	aroC	chorismate synthase [Shigella flexneri 2...	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1SQ1	46.3%	Shigella flexneri

IDP91258 (show subtarget assignments)	8	soluble	No	NT02SA1455	14247237	aroC	chorismate synthase [Staphylococcus aure...	388	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1QXO	56.7%	Staphylococcus aureus	Amino acid biosynthesis: Aromatic amino acid family

IDP90747 (show subtarget assignments)	8	soluble	No	Cj0001	15791400	dnaA	chromosomal replication initiation prote...	440	Predicted Essential	Community Requests	2Z4R	34.3%	Campylobacter jejuni

IDP00004 (show subtarget assignments)	1	soluble	No	BA_0001	38257418		Chromosomal replication initiator protei...	446	Drug Target Homolog	Phase 1: October 2007	2Z4R	37.2%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP00837 (show subtarget assignments)	1	purified	No	SACOL2735	57285289		chromosome partioning protein, ParB fami...	279	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	31.2%	Staphylococcus aureus	Cellular processes	Cell division

IDP01811 (show subtarget assignments)	1	expressed	No	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP91453 (show subtarget assignments)	8	cloned	No	VV1_0375	27363844		chromosome segregation ATPase [Vibrio vu...	250	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91393 (show subtarget assignments)	8	cloned	No	VV1_1096	27364519		chromosome segregation ATPase [Vibrio vu...	265	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP04036 (show subtarget assignments)	1	cloned	No	CPF_1970	110800938	smc	chromosome segregation protein SMC [Clos...	1185	conserved gene; putative drug target function;	Phase 4: April 2009	3AUX	8.2%	Clostridium perfringens	Cellular processes	Cell division

IDP00797 (show subtarget assignments)	1	expressed	No	SACOL1250	57285989		chromosome segregation SMC protein, puta...	1188	Conserved Gene / Pathway	Phase 2: March 2008	1W1W	7.5%	Staphylococcus aureus	Cellular processes	Cell division

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP02654 (show subtarget assignments)	1	cloned	No	Cj1682c	15792986	gltA	citrate synthase [Campylobacter jejuni s...	422	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	2H12	50.2%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP04634 (show subtarget assignments)	1	in_pdb 3MSU	No	FTT0071c	56707250	gltA	citrate synthase [Francisella tularensis...	424	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3MSU	100%	Francisella tularensis

IDP04280 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1108	115346887	gltA	citrate synthase GltA [Yersinia pestis C...	426	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1K3P	86.6%	Yersinia pestis	Energy metabolism	TCA cycle

IDP91707 (show subtarget assignments)	8	selected	No	NP_005447	4885433	MAPK8IP1	C-Jun-amino-terminal kinase-interacting ...	711	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2FPF	9.8%	Homo sapiens

IDP01651 (show subtarget assignments)	1	cloned	No	YPO2946	16123129	clpB5	Clp ATPase [Yersinia pestis CO92]	891	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	1QVR	35.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01772 (show subtarget assignments)	1	cloned	No	YPO3599	16123741	clpB2	Clp ATPase [Yersinia pestis CO92]	867	Drug target motif; CD; Drug target functions	Phase 3: June 2008	1QVR	33.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04143 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3275	115348911	clpB	Clp ATPase [Yersinia pestis CO92]	857	drug target; putative drug target function;	Phase 4: April 2009	1QVR	57.1%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP92126 (show subtarget assignments)	8	selected	No	TGME49_068650	237832521		clp ATP-binding chain B1, putative [Toxo...	929	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QVR	48.9%	Toxoplasma gondii

IDP01480 (show subtarget assignments)	1	cloned	No	VCA0116	15600887		clpB protein	869	Drug Target Function	Phase 2: March 2008	1QVR	36.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02116 (show subtarget assignments)	1	soluble	No	CBU_0094	29540716	clpB	clpB protein [Coxiella burnetii RSA 493]...	859	Conserved; Drug target functions	Phase 3: June 2008	1QVR	58.2%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02556 (show subtarget assignments)	1	soluble	No	FTT1769c	56708764	clpB	ClpB protein [Francisella tularensis sub...	859	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1QVR	55.3%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP92128 (show subtarget assignments)	8	selected	No	TGME49_082200	237844257		clpB protein, putative [Toxoplasma gondi...	970	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QVR	38.7%	Toxoplasma gondii

IDP91438 (show subtarget assignments)	8	soluble	No	VV1_0482	27363946		ClpB protein [Vibrio vulnificus CMCP6]	857	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1QVR	56%	Vibrio vulnificus

IDP05767 (show subtarget assignments)	1	soluble	No	S2798	30042221	acpS	CoA:apo-[acyl-carrier-protein] pantethei...	126	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3H88	55.6%	Shigella flexneri	Fatty acid and phospholipid metabolism: Biosynthesis

IDP05218 (show subtarget assignments)	1	expressed	No	CD3433	126701056	cbiB	cobalamin biosynthesis protein [Clostrid...	323	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05541 (show subtarget assignments)	1	cloned	No	CD3437	126701060	cobS	cobalamin synthase [Clostridium difficil...	257	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RH5	23.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01154 (show subtarget assignments)	1	expressed	No	BA_0139	56748760		Cobalt import ATP-binding protein cbiO 1...	280	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP05271 (show subtarget assignments)	1	cloned	No	lmo1194	16803234	cbiD	cobalt-precorrin-6A synthase [Listeria m...	373	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1SR8	23.1%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05322 (show subtarget assignments)	1	cloned	No	CD3430	126701053	cbiC	cobalt-precorrin-8X methylmutase [Clostr...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AFR	41.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04469 (show subtarget assignments)	1	cloned	No	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90845 (show subtarget assignments)	8	selected	No	S1357	30062792	btuR	cob(I)yrinic acid a,c-diamide adenosyltr...	196	Predicted Essential	Community Requests	1G5R	88.3%	Shigella flexneri

IDP90638 (show subtarget assignments)	8	soluble	No	VC1040	15641053		cob(I)yrinic acid a,c-diamide adenosyltr...	201	Predicted Essential	Community Requests	1G5R	64.2%	Vibrio cholerae

IDP91355 (show subtarget assignments)	8	soluble	No	VV1_3022	27366292		cob(I)yrinic acid a,c-diamide adenosyltr...	211	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1G5R	59.2%	Vibrio vulnificus

IDP01304 (show subtarget assignments)	1	in_pdb 3HHO	Yes	VC0751	15640770	hscB	co-chaperone HscB	171	Conserved Gene / Pathway	Phase 2: March 2008	3HHO	100%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01312 (show subtarget assignments)	1	crystallized	No	VCA0819	15601574	groES	co-chaperonin GroES	96	Conserved Gene / Pathway	Phase 2: March 2008	1AON	65.6%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01652 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1695	56708704	groES	co-chaperonin GroES [Francisella tularen...	95	Conserved; Drug target functions	Phase 3: June 2008	1AON	56.8%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP00576 (show subtarget assignments)	1	cloned	No	YPO1398	16121678	cspB	cold shock-like protein	69	Virulence Associated Factor	Phase 2: March 2008	3I2Z	50.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP01102 (show subtarget assignments)	1	soluble	No	BA_5424	49040749		Cold shock-like protein cspC	65	Essential Gene	Phase 2: March 2008	1C9O	74.2%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01732 (show subtarget assignments)	1	cloned	No	STM1243	16764598		cold shock-like protein [Salmonella typh...	70	Conserved; Drug target functions	Phase 3: June 2008	2L15	48.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP04328 (show subtarget assignments)	1	cloned	No	CPF_1452	110798743		cold shock protein [Clostridium perfring...	69	conserved gene; putative drug target function;	Phase 4: April 2009	2L15	56.3%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP00630 (show subtarget assignments)	1	cloned	No	SACOL0861	57284322		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	2I5M	71.2%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00623 (show subtarget assignments)	1	cloned	No	SACOL2731	57285285		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	2I5M	68.2%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00610 (show subtarget assignments)	1	cloned	No	SACOL1437	57286088		cold shock protein, CSD family	66	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	75.8%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP02334 (show subtarget assignments)	1	soluble	No	FTT0391c	56707540	cspC	cold shock protein [Francisella tularens...	67	Drug Target	Phase 3: June 2008	3I2Z	61.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP00579 (show subtarget assignments)	1	cloned	No	YPO1122	16121422	tolR	colicin uptake protein TolR	142	Conserved Gene / Pathway	Phase 2: March 2008	2JWK	23.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP05452 (show subtarget assignments)	1	cloned	No	BAS5207	49188193	-	collagen adhesion protein, C-terminal [B...	882	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3KPT	12.6%	Bacillus anthracis	Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP91985 (show subtarget assignments)	8	cloned	No	SpneCM_010100007069	298255345		collagen adhesion protein [Streptococcus...	171	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP91685 (show subtarget assignments)	8	selected	No	NP_000080	48762934	COL1A2	collagen alpha-2(I) chain precursor [Hom...	1366	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	3HQV	63.6%	Homo sapiens

IDP02563 (show subtarget assignments)	1	cloned	No	GBAA3299	47528584		collagenase, putative [Bacillus anthraci...	960	Drug target motif; Vaccine Target; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02298 (show subtarget assignments)	1	soluble	No	GBAA0555	47525828		collagenase,putative [Bacillus anthracis...	965	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	2Y3U	39.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05605 (show subtarget assignments)	1	cloned	No	BA_4978	30259470		collagen triple helix repeat domain prot...	469	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	27.7%	Bacillus anthracis	Unknown function: General

IDP05403 (show subtarget assignments)	1	soluble	No	BA_4464	30258958	comGC	comG operon protein 3 [Bacillus anthraci...	99	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: DNA transformation

IDP05402 (show subtarget assignments)	1	soluble	No	BA_4463	30258957	comGD	comG operon protein 4 [Bacillus anthraci...	151	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: DNA transformation

IDP92002 (show subtarget assignments)	8	selected	No	SpneCM_010100000145	298254010		competence protein CglD [Streptococcus p...	134	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP91326
(show subtarget assignments)

8

soluble

No

VV2_0291

27366737

chaperonin GroEL [Vibrio vulnificus CMCP...

210

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP02422
(show subtarget assignments)

1

cloned

No

YPO1666

16121930

cheA

chemotaxis protein CheA [Yersinia pestis...

723

Conserved; CD; Drug target functions

Phase 3: June 2008

1B3Q

22.7%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP05056
(show subtarget assignments)

1

soluble

No

CD0257

126697829

motB

chemotaxis protein [Clostridium difficil...

231

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2K1S

20.3%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05091
(show subtarget assignments)

1

cloned

No

CD0256

126697828

motA

chemotaxis protein [Clostridium difficil...

272

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP01029
(show subtarget assignments)

0

work_stopped

No

STM1916

16765258

cheY

chemotaxis regulator transmitting signal...

129

Conserved Gene / Pathway

Phase 2: March 2008

2FKA

100%

Salmonella enterica

Cellular processes

Other

IDP02322
(show subtarget assignments)

1

soluble

No

lmo0691

16802733

cheY

chemotaxis response regulator CheY [List...

119

Known virulence-Regulation; PMID:15155625

Phase 3: June 2008

1TMY

63.9%

Listeria monocytogenes

Regulatory functions

Other

IDP01934
(show subtarget assignments)

1

soluble

No

GBAA0385

47525656

chitinase B [Bacillus anthracis str. 'Am...

674

Drug target motif; Drug target functions

Phase 3: June 2008

1ITX

37.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00041
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2409

30257040

chloramphenicol acetyltransferase

216

Virulence

Phase 1: October 2007

1QCA

41.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01350
(show subtarget assignments)

1

in_pdb
3EEV

No

VCA0300

15601065

chloramphenicol acetyltransferase

209

Drug Target Function

Phase 2: March 2008

3EEV

100%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP90337
(show subtarget assignments)

8

expressed

No

CT_623

6578109

CHLPN 76kDa Homolog [Chlamydia trachomat...

432

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90413
(show subtarget assignments)

8

cloned

No

CT_622

3329069

CHLPN 76kDa Homolog [Chlamydia trachomat...

647

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90419
(show subtarget assignments)

8

cloned

No

CT_446

3328878

euo

CHLPS Euo Protein [Chlamydia trachomatis...

183

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90371
(show subtarget assignments)

8

cloned

No

CT_109

3328506

CHLPS hypothetical protein [Chlamydia tr...

262

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90397
(show subtarget assignments)

8

in_crystallization_trials

No

CT_583

3329026

gp6D

CHLTR Plasmid Paralog [Chlamydia trachom...

263

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90315
(show subtarget assignments)

8

cloned

No

CT_744

3329204

CHLTR possible phosphoprotein [Chlamydia...

821

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00142
(show subtarget assignments)

1

cloned

No

VC1456

15641467

ctxB

cholera enterotoxin, B subunit

124

Virulence

Phase 1: October 2007

1EEI

81.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91914
(show subtarget assignments)

8

selected

No

SpneCMD_010100003195

298229663

choline binding protein D [Streptococcus...

448

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2V04

14.3%

Streptococcus pneumoniae

IDP91919
(show subtarget assignments)

8

selected

No

SpneCM_010100003360

298254637

choline binding protein G [Streptococcus...

197

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P3C

24.9%

Streptococcus pneumoniae

IDP91974
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100003435

298254652

choline binding protein J [Streptococcus...

332

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2VYU

58.2%

Streptococcus pneumoniae

IDP91921
(show subtarget assignments)

8

selected

No

SpneCM_010100000547

298254088

choline binding protein PcpA, partial [S...

222

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2V04

44.6%

Streptococcus pneumoniae

IDP00833
(show subtarget assignments)

1

cloned

No

SACOL2627

57286532

betA

choline dehydrogenase

569

Conserved Gene / Pathway

Phase 2: March 2008

3LJP

32.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00056
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3898

30258412

choloylglycine hydrolase family protein ...

328

Virulence

Phase 1: October 2007

2OQC

48.8%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP91298
(show subtarget assignments)

8

cloned

No

STM1269

16764620

-

chorismate mutase

181

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2GBB

27.6%

Salmonella enterica

IDP01211
(show subtarget assignments)

1

crystallized

No

BA_2958

30257549

chorismate mutase/phospho-2-dehydro-3-de...

358

Drug Target Function

Phase 2: March 2008

3NVT

69.8%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP91304
(show subtarget assignments)

8

soluble

No

STM2667

16765982

pheA

chorismate mutase P/prephenate dehydrata...

386

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1ECM

25.1%

Salmonella enterica

IDP90772
(show subtarget assignments)

8

soluble

No

Cj0316

15791684

pheA

chorismate mutase/prephenate dehydratase...

357

Predicted Essential

Community Requests

3MWB

27.5%

Campylobacter jejuni

IDP00319
(show subtarget assignments)

1

expressed

No

CBU_2070

29655348

chorismate mutase, putative

136

Drug Target Function

Phase 2: March 2008

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02059
(show subtarget assignments)

1

expressed

No

YPO1353

16121633

chorismate mutase [Yersinia pestis CO92]...

186

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2GBB

83.9%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP02012
(show subtarget assignments)

1

soluble

No

STM4233

16767483

ubiC

chorismate pyruvate lyase [Salmonella ty...

165

Conserved; Drug target functions

Phase 3: June 2008

1G1B

86.1%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90584
(show subtarget assignments)

8

purified

No

VC0095

15640127

chorismate--pyruvate lyase [Vibrio chole...

183

Predicted Essential

Community Requests

1FW9

28.4%

Vibrio cholerae

IDP90522
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0310

16120648

ubiC

chorismate pyruvate lyase [Yersinia pest...

174

Predicted Essential

Community Requests

1G1B

50.6%

Yersinia pestis

IDP91303
(show subtarget assignments)

8

soluble

No

STM2384

16765711

aroC

chorismate synthase

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1SQ1

45.7%

Salmonella enterica

IDP00539
(show subtarget assignments)

1

purified

No

YPO2751

16122955

aroC

chorismate synthase

361

Conserved Gene / Pathway

Phase 2: March 2008

1R52

45%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP00338
(show subtarget assignments)

1

cloned

No

FTT0876c

56707980

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1UM0

47.4%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00327
(show subtarget assignments)

0

work_stopped

No

Cj1634c

15792939

aroC

chorismate synthase

362

Drug Target Function

Phase 2: March 2008

1SQ1

100%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00315
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0874

29654200

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1R52

44.7%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01199
(show subtarget assignments)

1

purified

No

BA_1537

67460530

Chorismate synthase 1 (5-enolpyruvylshik...

390

Drug Target Function

Phase 2: March 2008

1QXO

59%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP90161
(show subtarget assignments)

8

purified

No

CD1835

123174273

Chorismate synthase (5-enolpyruvylshikim...

359

Potential drug target. Shikimate pathway enzyme

Community Requests

1UM0

38.7%

Clostridium difficile

IDP91209
(show subtarget assignments)

8

expressed

No

BT_2084

29347494

chorismate synthase [Bacteroides thetaio...

358

potential drug target / Shikimate pathway enzyme

Community Requests

1R52

47.9%

Bacteroides thetaiotaomicron

IDP91213
(show subtarget assignments)

8

in_pdb
4ECD

No

Blon_1598

189439475

aroC

chorismate synthase [Bifidobacterium lon...

395

potential drug target / Shikimate pathway enzyme

Community Requests

4ECD

100%

Bifidobacterium longum

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP91230
(show subtarget assignments)

8

soluble

No

NT04EC2956

26109123

aroC

Chorismate synthase [Escherichia coli CF...

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1SQ1

46.5%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP05341
(show subtarget assignments)

1

cloned

No

lmo1928

16803967

aroF

chorismate synthase [Listeria monocytoge...

388

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1QXO

63.1%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP92110
(show subtarget assignments)

8

selected

No

TGME49_001380

237836313

chorismate synthase, putative [Toxoplasm...

536

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1R52

36.9%

Toxoplasma gondii

IDP91285
(show subtarget assignments)

8

soluble

No

SPA0480

56412719

aroC

chorismate synthase [Salmonella enterica...

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1R52

45.7%

Salmonella enterica

IDP91284
(show subtarget assignments)

8

cloned

No

SF2405

56480091

aroC

chorismate synthase [Shigella flexneri 2...

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1SQ1

46.3%

Shigella flexneri

IDP91258
(show subtarget assignments)

8

soluble

No

NT02SA1455

14247237

aroC

chorismate synthase [Staphylococcus aure...

388

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1QXO

56.7%

Staphylococcus aureus

Amino acid biosynthesis: Aromatic amino acid family

IDP90747
(show subtarget assignments)

8

soluble

No

Cj0001

15791400

dnaA

chromosomal replication initiation prote...

440

Predicted Essential

Community Requests

2Z4R

34.3%

Campylobacter jejuni

IDP00004
(show subtarget assignments)

1

soluble

No

BA_0001

38257418

Chromosomal replication initiator protei...

446

Drug Target Homolog

Phase 1: October 2007

2Z4R

37.2%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP00837
(show subtarget assignments)

1

purified

No

SACOL2735

57285289

chromosome partioning protein, ParB fami...

279

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

31.2%

Staphylococcus aureus

Cellular processes

Cell division

IDP01811
(show subtarget assignments)

1

expressed

No

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP91453
(show subtarget assignments)

8

cloned

No

VV1_0375

27363844

chromosome segregation ATPase [Vibrio vu...

250

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91393
(show subtarget assignments)

8

cloned

No

VV1_1096

27364519

chromosome segregation ATPase [Vibrio vu...

265

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP04036
(show subtarget assignments)

1

cloned

No

CPF_1970

110800938

smc

chromosome segregation protein SMC [Clos...

1185

conserved gene; putative drug target function;

Phase 4: April 2009

3AUX

8.2%

Clostridium perfringens

Cellular processes

Cell division

IDP00797
(show subtarget assignments)

1

expressed

No

SACOL1250

57285989

chromosome segregation SMC protein, puta...

1188

Conserved Gene / Pathway

Phase 2: March 2008

1W1W

7.5%

Staphylococcus aureus

Cellular processes

Cell division

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP02654
(show subtarget assignments)

1

cloned

No

Cj1682c

15792986

gltA

citrate synthase [Campylobacter jejuni s...

422

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

2H12

50.2%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP04634
(show subtarget assignments)

1

in_pdb
3MSU

No

FTT0071c

56707250

gltA

citrate synthase [Francisella tularensis...

424

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3MSU

100%

Francisella tularensis

IDP04280
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1108

115346887

gltA

citrate synthase GltA [Yersinia pestis C...

426

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1K3P

86.6%

Yersinia pestis

Energy metabolism

TCA cycle

IDP91707
(show subtarget assignments)

8

selected

No

NP_005447

4885433

MAPK8IP1

C-Jun-amino-terminal kinase-interacting ...

711

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2FPF

9.8%

Homo sapiens

IDP01651
(show subtarget assignments)

1

cloned

No

YPO2946

16123129

clpB5

Clp ATPase [Yersinia pestis CO92]

891

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

1QVR

35.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01772
(show subtarget assignments)

1

cloned

No

YPO3599

16123741

clpB2

Clp ATPase [Yersinia pestis CO92]

867

Drug target motif; CD; Drug target functions

Phase 3: June 2008

1QVR

33.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04143
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3275

115348911

clpB

Clp ATPase [Yersinia pestis CO92]

857

drug target; putative drug target function;

Phase 4: April 2009

1QVR

57.1%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP92126
(show subtarget assignments)

8

selected

No

TGME49_068650

237832521

clp ATP-binding chain B1, putative [Toxo...

929

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QVR

48.9%

Toxoplasma gondii

IDP01480
(show subtarget assignments)

1

cloned

No

VCA0116

15600887

clpB protein

869

Drug Target Function

Phase 2: March 2008

1QVR

36.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02116
(show subtarget assignments)

1

soluble

No

CBU_0094

29540716

clpB

clpB protein [Coxiella burnetii RSA 493]...

859

Conserved; Drug target functions

Phase 3: June 2008

1QVR

58.2%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02556
(show subtarget assignments)

1

soluble

No

FTT1769c

56708764

clpB

ClpB protein [Francisella tularensis sub...

859

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1QVR

55.3%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP92128
(show subtarget assignments)

8

selected

No

TGME49_082200

237844257

clpB protein, putative [Toxoplasma gondi...

970

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QVR

38.7%

Toxoplasma gondii

IDP91438
(show subtarget assignments)

8

soluble

No

VV1_0482

27363946

ClpB protein [Vibrio vulnificus CMCP6]

857

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1QVR

56%

Vibrio vulnificus

IDP05767
(show subtarget assignments)

1

soluble

No

S2798

30042221

acpS

CoA:apo-[acyl-carrier-protein] pantethei...

126

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3H88

55.6%

Shigella flexneri

Fatty acid and phospholipid metabolism: Biosynthesis

IDP05218
(show subtarget assignments)

1

expressed

No

CD3433

126701056

cbiB

cobalamin biosynthesis protein [Clostrid...

323

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05541
(show subtarget assignments)

1

cloned

No

CD3437

126701060

cobS

cobalamin synthase [Clostridium difficil...

257

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RH5

23.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP01154
(show subtarget assignments)

1

expressed

No

BA_0139

56748760

Cobalt import ATP-binding protein cbiO 1...

280

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP05271
(show subtarget assignments)

1

cloned

No

lmo1194

16803234

cbiD

cobalt-precorrin-6A synthase [Listeria m...

373

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1SR8

23.1%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05322
(show subtarget assignments)

1

cloned

No

CD3430

126701053

cbiC

cobalt-precorrin-8X methylmutase [Clostr...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AFR

41.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04469
(show subtarget assignments)

1

cloned

No

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90845
(show subtarget assignments)

8

selected

No

S1357

30062792

btuR

cob(I)yrinic acid a,c-diamide adenosyltr...

196

Predicted Essential

Community Requests

1G5R

88.3%

Shigella flexneri

IDP90638
(show subtarget assignments)

8

soluble

No

VC1040

15641053

cob(I)yrinic acid a,c-diamide adenosyltr...

201

Predicted Essential

Community Requests

1G5R

64.2%

Vibrio cholerae

IDP91355
(show subtarget assignments)

8

soluble

No

VV1_3022

27366292

cob(I)yrinic acid a,c-diamide adenosyltr...

211

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1G5R

59.2%

Vibrio vulnificus

IDP01304
(show subtarget assignments)

1

in_pdb
3HHO

Yes

VC0751

15640770

hscB

co-chaperone HscB

171

Conserved Gene / Pathway

Phase 2: March 2008

3HHO

100%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01312
(show subtarget assignments)

1

crystallized

No

VCA0819

15601574

groES

co-chaperonin GroES

96

Conserved Gene / Pathway

Phase 2: March 2008

1AON

65.6%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01652
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1695

56708704

groES

co-chaperonin GroES [Francisella tularen...

95

Conserved; Drug target functions

Phase 3: June 2008

1AON

56.8%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP00576
(show subtarget assignments)

1

cloned

No

YPO1398

16121678

cspB

cold shock-like protein

69

Virulence Associated Factor

Phase 2: March 2008

3I2Z

50.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP01102
(show subtarget assignments)

1

soluble

No

BA_5424

49040749

Cold shock-like protein cspC

65

Essential Gene

Phase 2: March 2008

1C9O

74.2%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01732
(show subtarget assignments)

1

cloned

No

STM1243

16764598

cold shock-like protein [Salmonella typh...

70

Conserved; Drug target functions

Phase 3: June 2008

2L15

48.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP04328
(show subtarget assignments)

1

cloned

No

CPF_1452

110798743

cold shock protein [Clostridium perfring...

69

conserved gene; putative drug target function;

Phase 4: April 2009

2L15

56.3%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP00630
(show subtarget assignments)

1

cloned

No

SACOL0861

57284322

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

2I5M

71.2%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00623
(show subtarget assignments)

1

cloned

No

SACOL2731

57285285

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

2I5M

68.2%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00610
(show subtarget assignments)

1

cloned

No

SACOL1437

57286088

cold shock protein, CSD family

66

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

75.8%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP02334
(show subtarget assignments)

1

soluble

No

FTT0391c

56707540

cspC

cold shock protein [Francisella tularens...

67

Drug Target

Phase 3: June 2008

3I2Z

61.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP00579
(show subtarget assignments)

1

cloned

No

YPO1122

16121422

tolR

colicin uptake protein TolR

142

Conserved Gene / Pathway

Phase 2: March 2008

2JWK

23.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP05452
(show subtarget assignments)

1

cloned

No

BAS5207

49188193

-

collagen adhesion protein, C-terminal [B...

882

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3KPT

12.6%

Bacillus anthracis

Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP91985
(show subtarget assignments)

8

cloned

No

SpneCM_010100007069

298255345

collagen adhesion protein [Streptococcus...

171

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP91685
(show subtarget assignments)

8

selected

No

NP_000080

48762934

COL1A2

collagen alpha-2(I) chain precursor [Hom...

1366

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

3HQV

63.6%

Homo sapiens

IDP02563
(show subtarget assignments)

1

cloned

No

GBAA3299

47528584

collagenase, putative [Bacillus anthraci...

960

Drug target motif; Vaccine Target; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02298
(show subtarget assignments)

1

soluble

No

GBAA0555

47525828

collagenase,putative [Bacillus anthracis...

965

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

2Y3U

39.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05605
(show subtarget assignments)

1

cloned

No

BA_4978

30259470

collagen triple helix repeat domain prot...

469

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

27.7%

Bacillus anthracis

Unknown function: General

IDP05403
(show subtarget assignments)

1

soluble

No

BA_4464

30258958

comGC

comG operon protein 3 [Bacillus anthraci...

99

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: DNA transformation

IDP05402
(show subtarget assignments)

1

soluble

No

BA_4463

30258957

comGD

comG operon protein 4 [Bacillus anthraci...

151

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: DNA transformation

IDP92002
(show subtarget assignments)

8

selected

No

SpneCM_010100000145

298254010

competence protein CglD [Streptococcus p...

134

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae