Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01623 (show subtarget assignments)	1	cloned	No	GBAA5019	47530321	pckA	phosphoenolpyruvate carboxykinase [Bacil...	528	Conserved; Essential; Drug target functions	Phase 3: June 2008	1J3B	52.8%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01766 (show subtarget assignments)	1	cloned	No	GBAA_pXO2_0063	47566732	ggt	gamma-glutamyltranspeptidase, (pxo2-55) ...	528	Drug target motif; Drug target homolog;	Phase 3: June 2008	3G9K	61.2%	Bacillus anthracis	N/A	N/A

IDP05031 (show subtarget assignments)	1	soluble	No	BA_0908	30254654		oligopeptide ABC transporter, oligopepti...	528	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	30.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP01189 (show subtarget assignments)	1	expressed	No	BA_0505	30254033		glycosyl transferase, group 2 family pro...	528	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90338 (show subtarget assignments)	8	cloned	No	CT087	15604806	malQ	4-alpha-glucanotransferase [Chlamydia tr...	527	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2X1I	25.2%	Chlamydia trachomatis

IDP04185 (show subtarget assignments)	1	expressed	No	VCA0683	15601440		sensor protein UhpB [Vibrio cholerae O1 ...	527	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GIG	12%	Vibrio cholerae	Regulatory functions	Other

IDP05562 (show subtarget assignments)	1	cloned	No	lmo2172	16804211	-	hypothetical protein lmo2172 [Listeria m...	527	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2AHU	42.1%	Listeria monocytogenes	Energy metabolism: Fermentation

IDP05521 (show subtarget assignments)	1	cloned	No	CD1858	126699468		putative cell surface protein [Clostridi...	526	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP91554 (show subtarget assignments)	8	expressed	No	BAB38444	13364498	ECs5021	hypothetical protein [Escherichia coli O...	526	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3NAW	20.9%	Escherichia coli

IDP00509 (show subtarget assignments)	1	in_pdb 3RY3	No	YPO2660	16122866		putative solute-binding protein	525	Conserved Gene / Pathway	Phase 2: March 2008	3RY3	100%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP04478 (show subtarget assignments)	1	soluble	No	YPO2870	115348541	guaA	putative GMP synthase [Yersinia pestis C...	525	drug target; putative drug target function;	Phase 4: April 2009	1GPM	87.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05306 (show subtarget assignments)	1	cloned	No	CD2786	126700402		cell surface protein [Clostridium diffic...	525	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP04093 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1907	218929023	irp5	yersiniabactin siderophore biosynthetic ...	525	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1MD9	47.8%	Yersinia pestis	Cellular processes	Cell division

IDP90973 (show subtarget assignments)	8	selected	No	AND4_00045	163803697		RTX toxin RtxA [Vibrio sp. AND4]	525	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Vibrio sp.

IDP92038 (show subtarget assignments)	8	selected	No	TGME49_034500	237839185		phenylalanyl tRNA synthetase isoform, pu...	525	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3L4G	47%	Toxoplasma gondii

IDP05074 (show subtarget assignments)	1	cloned	No	lmo0135	16802183	-	hypothetical protein lmo0135 [Listeria m...	524	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	32.4%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP01417 (show subtarget assignments)	1	soluble	No	VC1414	15641425		thermostable carboxypeptidase 1	524	Drug Target Function	Phase 2: March 2008	3DWC	44.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91530 (show subtarget assignments)	8	purified	No	VC1268	15641281		hypothetical protein VC1268 [Vibrio chol...	524	other biological interest / We have recently established that D-amino acids are important signal molecules t...	Community Requests			Vibrio cholerae

IDP90171 (show subtarget assignments)	8	cloned	No	AAM13460.1	20152999	CPXV013 CDS	CPXV013 protein	523	kelch-like protein	Community Requests	3HVE	10.1%	Cowpox virus	conserved hypothetical proteins	0

IDP91561 (show subtarget assignments)	8	purified	No	BAB33895	13359929	ECs0472	hypothetical protein [Escherichia coli O...	523	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP02611 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0111	47566431		M23/37 family peptidase [Bacillus anthra...	523	Drug target motif; Vaccine Target	Phase 3: June 2008	2GU1	10.1%	Bacillus anthracis	N/A	N/A

IDP90295 (show subtarget assignments)	8	cloned	No	TGME49_005290	211965425		dual-specificity phosphatase laforin, pu...	523	Human Lafora disease is one of five major progressive myoclonus epilepsies that ...	Community Requests			Toxoplasma gondii

IDP01413 (show subtarget assignments)	1	purified	No	VC1174	15641187		anthranilate synthase component I	523	Drug Target Function	Phase 2: March 2008	1I1Q	59.3%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP02659 (show subtarget assignments)	1	cloned	No	lmo0988	16803028	prfC	peptide chain release factor 3 [Listeria...	522	Predicted virulence-Regulation	Phase 3: June 2008	3TR5	48.5%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP05135 (show subtarget assignments)	1	soluble	No	CD0855	126698435	oppA	oligopeptide ABC transporter, substrate-...	522	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	33.1%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05181 (show subtarget assignments)	1	soluble	No	BA_4729	30259221		bacterial extracellular solute-binding p...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1UQW	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP91898 (show subtarget assignments)	8	selected	No	SpneCM_010100003105	298254588		amino acid ABC transporter, amino acid-b...	521	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3I6V	13.4%	Streptococcus pneumoniae

IDP05530 (show subtarget assignments)	1	cloned	No	CD1534	126699138		putative gamma-glutamyltranspeptidase [C...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NLZ	54.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs

IDP00440 (show subtarget assignments)	1	purified	No	YPO2208	16122436	trpE	anthranilate synthase component I	521	Conserved Gene / Pathway	Phase 2: March 2008	1I7Q	79.7%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP90285 (show subtarget assignments)	8	soluble	No	TGME49_083850	211966798		peptidyl-prolyl isomerase, putative [Tox...	521	The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...	Community Requests	1KT0	23.2%	Toxoplasma gondii

IDP02076 (show subtarget assignments)	1	soluble	No	STM3216	16766515		putative methyl-accepting chemotaxis pro...	521	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	28.6%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP91644 (show subtarget assignments)	8	purified	No	NP_215861	15608485		long-chain-fatty-acid--[acyl-carrier-pro...	521	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	3PBK	31.5%	Mycobacterium tuberculosis

IDP02163 (show subtarget assignments)	1	cloned	No	GBAA3914	47529205		phosphodiesterase [Bacillus anthracis st...	520	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	General

IDP91300 (show subtarget assignments)	8	soluble	No	STM1723	16765067	trpE	anthranilate synthase component I	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	99.8%	Salmonella enterica

IDP02463 (show subtarget assignments)	1	expressed	No	YPO1769	16122023	hpaB	4-hydroxyphenylacetate 3-monooxygenase [...	520	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2YYG	28.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Degradation

IDP91232 (show subtarget assignments)	8	expressed	No	NT04EC1776	26107995	trpE	Anthranilate synthase component I [Esche...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	89.6%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP04713 (show subtarget assignments)	1	purified	No	YPO0533	218927730	leuA	2-isopropylmalate synthase [Yersinia pes...	520	conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	36.3%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP91286 (show subtarget assignments)	8	expressed	No	SPA1154	56413352	trpE	anthranilate synthase component I [Salmo...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	99%	Salmonella enterica

IDP91223 (show subtarget assignments)	8	purified	No	SF1267	24112663	trpE	anthranilate synthase component I [Shige...	520	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	89.2%	Shigella flexneri

IDP91343 (show subtarget assignments)	8	expressed	No	VV2_0072	27366531		methyl-accepting chemotaxis protein [Vib...	519	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3ZX6	17.7%	Vibrio vulnificus

IDP05711 (show subtarget assignments)	1	soluble	No	BAS1732	49184745	-	oligopeptide ABC transporter, solute bin...	519	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	28.5%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP02550 (show subtarget assignments)	1	in_pdb 3RF0	Yes	YPO2837	16123032	ppx	exopolyphosphatase [Yersinia pestis CO92...	519	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1U6Z	76.3%	Yersinia pestis	Central intermediary metabolism	Phosphorus compounds

IDP05249 (show subtarget assignments)	1	soluble	No	BAS2289	49185298	-	hypothetical protein BAS2289 [Bacillus a...	512	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: General

IDP90353 (show subtarget assignments)	8	expressed	No	CT198	15604918	oppA_3	oligopeptide binding protein [Chlamydia ...	518	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1UIU	25.5%	Chlamydia trachomatis

IDP02230 (show subtarget assignments)	1	cloned	No	YPO0829	16121138		putative sulfatase [Yersinia pestis CO92...	517	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2QZU	40.2%	Yersinia pestis	Unknown function	Enzymes of unknown specificity

IDP00829 (show subtarget assignments)	1	purified	No	SACOL2515	57285199	gntK	gluconokinase	517	Drug Target Function	Phase 2: March 2008	3GBT	39.3%	Staphylococcus aureus	Energy metabolism	Sugars

IDP04497 (show subtarget assignments)	1	soluble	No	VC0768	9655215		GMP synthase [Vibrio cholerae O1 biovar ...	517	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	80.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04540 (show subtarget assignments)	1	purified	No	CPF_0511	110801291		sensor histidine kinase [Clostridium per...	516	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	18.2%	Clostridium perfringens	Signal transduction	Two-component systems

IDP05190 (show subtarget assignments)	1	cloned	No	CD0248	126697819	fliF	flagellar MS-ring protein [Clostridium d...	516	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04173 (show subtarget assignments)	1	expressed	No	VC2490	15642486		2-isopropylmalate synthase [Vibrio chole...	516	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RMJ	39%	Vibrio cholerae	Amino acid biosynthesis	Pyruvate family

IDP04526 (show subtarget assignments)	1	expressed	No	STM1637_1_516	16764981		putative inner membrane protein [Salmone...	516	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP02219 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1019c	56708108	guaA	bifunctional GMP synthase/glutamine amid...	516	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1GPM	61.1%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05219 (show subtarget assignments)	1	cloned	No	CD3567	126701193		putative cell wall hydrolase [Clostridiu...	516	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Sporulation and germination

IDP04458 (show subtarget assignments)	1	soluble	No	YPO1466	115347220		conserved hypothetical protein [Yersinia...	516	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP02302 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0203c	56707367	purH	bifunctional phosphoribosylaminoimidazol...	515	Drug Target	Phase 3: June 2008	3ZZM	47.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP92118 (show subtarget assignments)	8	selected	No	TGME49_015480	237843139		adenosine/AMP deaminase domain containin...	515	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3OU8	21.7%	Toxoplasma gondii

IDP92023 (show subtarget assignments)	8	selected	No	TGME49_010260	237845081		glycerol-3-phosphate dehydrogenase, puta...	515	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1YJ8	33.2%	Toxoplasma gondii

IDP02033 (show subtarget assignments)	1	cloned	No	Cj1135	15792460		glycosyltransferase [Campylobacter jejun...	515	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	2Z86	14%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02117 (show subtarget assignments)	1	in_crystallization_trials	No	STM4356	16767602	yjeF	hypothetical protein STM4356 [Salmonella...	515	Conserved; Drug target functions	Phase 3: June 2008	2AX3	31.3%	Salmonella enterica	Unknown function	General

IDP05716 (show subtarget assignments)	1	soluble	No	BA_0692	30254291		conserved hypothetical protein [Bacillus...	515	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP90219 (show subtarget assignments)	8	expressed	No	MYXV_gp011	9633802	m008L	m008L, m8	515	contains kelch motifs, similar to MYX-L-m006R	Community Requests	2XN4	11.5%	Myxoma virus	unknown	0

IDP91925 (show subtarget assignments)	8	selected	No	SpneCM_010100003175	298254600	prfC	peptide chain release factor 3 [Streptoc...	514	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3TR5	48.1%	Streptococcus pneumoniae

IDP04556 (show subtarget assignments)	1	cloned	No	YPO3008	218930055		putative two-component sensor histidine ...	514	putative drug target function;	Phase 4: April 2009	2C2A	16%	Yersinia pestis	Regulatory functions	Other

IDP01679 (show subtarget assignments)	1	cloned	No	FTT0738	56707853	yjeF	carbohydrate kinase family protein (YjeF...	514	Conserved; Drug target functions	Phase 3: June 2008	2AX3	28%	Francisella tularensis	Energy metabolism	Sugars

IDP01930 (show subtarget assignments)	1	expressed	No	STM1578	16764922	narY	nitrate reductase 2 beta subunit [Salmon...	514	Conserved; Essential; Drug target functions	Phase 3: June 2008	1Q16	79%	Salmonella enterica	Energy metabolism	Anaerobic

IDP00342 (show subtarget assignments)	1	cloned	No	FTT1802c	56708788	trpE	anthranilate synthase component I	514	Drug Target Function	Phase 2: March 2008	1I1Q	51.1%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP90256 (show subtarget assignments)	8	crystallized	No	SAR0409	49482642	guaA	bifunctional GMP synthase/glutamine amid...	513	(From requestor) Identified potential S. aureus drug target. Would like to devel...	Community Requests	1GPM	51.2%	Staphylococcus aureus

IDP05122 (show subtarget assignments)	1	expressed	No	BA_3551	30258083	amyS	alpha-amylase [Bacillus anthracis str. A...	513	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VJS	68.6%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01802 (show subtarget assignments)	1	crystallized	No	FTT0062	56707241	atpA	F0F1 ATP synthase subunit alpha [Francis...	513	Conserved; Drug target functions	Phase 3: June 2008	3OAA	71%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP02593 (show subtarget assignments)	1	expressed	No	YPO3426	16123575	hofB	hypothetical protein YPO3426 [Yersinia p...	512	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	34.2%	Yersinia pestis	Cell envelope	Surface structures

IDP02108 (show subtarget assignments)	1	in_crystallization_trials	No	STM3680	16766965	aldB	aldehyde dehydrogenase B [Salmonella typ...	512	Conserved; Drug target functions	Phase 3: June 2008	1NZW	40.6%	Salmonella enterica	Energy metabolism	Other

IDP90183 (show subtarget assignments)	8	cloned	No	AAM13482.1	20153021	CPXV035 CDS	CPXV035 protein	512	kelch-like protein	Community Requests	2XN4	12.7%	Cowpox virus	conserved hypothetical proteins	0

IDP91697 (show subtarget assignments)	8	selected	No	NP_002341	4505055	LYN	tyrosine-protein kinase Lyn isoform A [H...	512	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2C0I	66.6%	Homo sapiens

IDP05355 (show subtarget assignments)	1	cloned	No	CD3506	126701130		hypothetical protein CD3506 [Clostridium...	512	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP00049 (show subtarget assignments)	0	work_stopped	No	BA_3355	30257898		thiol-activated cytolysin	512	Virulence	Phase 1: October 2007	3CQF	93.6%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01456 (show subtarget assignments)	1	purified	No	VC2406	15642403	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	512	Conserved Gene / Pathway	Phase 2: March 2008	1E8C	50.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90889 (show subtarget assignments)	8	cloned	No	VC0664	15640683	lysS	lysyl-tRNA synthetase [Vibrio cholerae O...	512	Predicted Essential	Community Requests	1E1O	58.8%	Vibrio cholerae

IDP02486 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4209	47529502		Ppx/GppA phosphatase family protein [Bac...	512	Conserved; Drug target functions	Phase 3: June 2008	3HI0	23%	Bacillus anthracis	Central intermediary metabolism	Phosphorus compounds

IDP02560 (show subtarget assignments)	1	cloned	No	GBAA0268	47777798	guaA	bifunctional GMP synthase/glutamine amid...	512	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPM	52.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90724 (show subtarget assignments)	8	expressed	No	Cj1719c	15793022	leuA	2-isopropylmalate synthase [Campylobacte...	511	Predicted Essential	Community Requests	3RMJ	37.6%	Campylobacter jejuni

IDP91106 (show subtarget assignments)	8	in_pdb 3QFK	Yes	SAOUHSC_00107	88193920		hypothetical protein SAOUHSC_00107 [Stap...	511	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3QFK	99.8%	Staphylococcus aureus

IDP90695 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1248	15792572	guaA	bifunctional GMP synthase/glutamine amid...	511	Predicted Essential	Community Requests	1GPM	51.8%	Campylobacter jejuni

IDP01186 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0298	81584380		Bifunctional purine biosynthesis protein...	511	Conserved Gene / Pathway	Phase 2: March 2008	3ZZM	44.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00569 (show subtarget assignments)	1	purified	No	YPO4016	16124139	hutH	histidine ammonia-lyase	510	Drug Target Function	Phase 2: March 2008	1GK2	77.5%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP90570 (show subtarget assignments)	8	in_pdb 4EHI	No	Cj0953c	15792282	purH	bifunctional phosphoribosylaminoimidazol...	510	Predicted Essential	Community Requests	3ZZM	39.2%	Campylobacter jejuni

IDP02285 (show subtarget assignments)	1	soluble	No	FTT0132	56707303	glpA	anaerobic glycerol-3-phosphate dehydroge...	510	Drug Target	Phase 3: June 2008	3DA1	33.1%	Francisella tularensis	Energy metabolism	Other

IDP02657 (show subtarget assignments)	1	cloned	No	lmo0203	16802249	mpl	Zinc metalloproteinase precursor [Lister...	510	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...	Phase 3: June 2008	1BQB	27.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01217 (show subtarget assignments)	1	expressed	No	BA_3695	30258216		S-layer protein, putative	510	Drug Target Function	Phase 2: March 2008	3PYW	10.2%	Bacillus anthracis	Cell envelope	Surface structures

IDP90215 (show subtarget assignments)	8	expressed	No	MYXV_gp009	9633800	m006L	m006L, m6	509	contains kelch motifs, similar to MYX-L-m006R	Community Requests	1X2J	13.9%	Myxoma virus	unknown	0

IDP91399 (show subtarget assignments)	8	soluble	No	VV1_1028	27364461		threonine dehydratase [Vibrio vulnificus...	509	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1TDJ	70.1%	Vibrio vulnificus

IDP02753 (show subtarget assignments)	1	expressed	No	GBAA4662	47529960	nadB	L-aspartate oxidase [Bacillus anthracis ...	509	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CHU	37.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00177 (show subtarget assignments)	1	purified	No	YPO3007	16123186	-	putative membrane protein	509	Virulence	Phase 1: October 2007			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92116 (show subtarget assignments)	8	selected	No	TGME49_060680	237831887		DNA primase small subunit, putative [Tox...	509	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1G71	9.2%	Toxoplasma gondii

IDP04199 (show subtarget assignments)	1	cloned	No	CPF_2557	110800712	guaA	bifunctional GMP synthase/glutamine amid...	509	conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	52.3%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01119 (show subtarget assignments)	1	purified	No	BA_0344	30253882	ahpF	alkyl hydroperoxide reductase, F subunit...	508	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	55.7%	Bacillus anthracis	Cellular processes	Detoxification

IDP05328 (show subtarget assignments)	1	soluble	No	lmo2591	16804629	-	GW repeat-containing surface protein [Li...	508	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	17.7%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP00782 (show subtarget assignments)	1	cloned	No	SACOL0857	57284318		staphylocoagulase precursor, putative	508	Conserved Gene / Pathway	Phase 2: March 2008	2A1D	16.9%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP00754 (show subtarget assignments)	0	work_stopped	No	SACOL0095	57286644	spa	immunoglobulin G binding protein A precu...	508	Conserved Gene / Pathway	Phase 2: March 2008	1BDC	11.6%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP05140 (show subtarget assignments)	1	soluble	No	BAS0382	49183410	-	prolyl-tRNA synthetase [Bacillus anthrac...	508	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H4Q	48.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP92073 (show subtarget assignments)	8	selected	No	TGME49_088860	237838049		ruvB-like 2 protein, putative [Toxoplasm...	508	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2XSZ	49.2%	Toxoplasma gondii

IDP01623
(show subtarget assignments)

1

cloned

No

GBAA5019

47530321

pckA

phosphoenolpyruvate carboxykinase [Bacil...

528

Conserved; Essential; Drug target functions

Phase 3: June 2008

1J3B

52.8%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01766
(show subtarget assignments)

1

cloned

No

GBAA_pXO2_0063

47566732

ggt

gamma-glutamyltranspeptidase, (pxo2-55) ...

528

Drug target motif; Drug target homolog;

Phase 3: June 2008

3G9K

61.2%

Bacillus anthracis

N/A

IDP05031
(show subtarget assignments)

1

soluble

No

BA_0908

30254654

oligopeptide ABC transporter, oligopepti...

528

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

30.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP01189
(show subtarget assignments)

1

expressed

No

BA_0505

30254033

glycosyl transferase, group 2 family pro...

528

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90338
(show subtarget assignments)

8

cloned

No

CT087

15604806

malQ

4-alpha-glucanotransferase [Chlamydia tr...

527

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2X1I

25.2%

Chlamydia trachomatis

IDP04185
(show subtarget assignments)

1

expressed

No

VCA0683

15601440

sensor protein UhpB [Vibrio cholerae O1 ...

527

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GIG

12%

Vibrio cholerae

Regulatory functions

Other

IDP05562
(show subtarget assignments)

1

cloned

No

lmo2172

16804211

-

hypothetical protein lmo2172 [Listeria m...

527

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2AHU

42.1%

Listeria monocytogenes

Energy metabolism: Fermentation

IDP05521
(show subtarget assignments)

1

cloned

No

CD1858

126699468

putative cell surface protein [Clostridi...

526

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP91554
(show subtarget assignments)

8

expressed

No

BAB38444

13364498

ECs5021

hypothetical protein [Escherichia coli O...

526

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3NAW

20.9%

Escherichia coli

IDP00509
(show subtarget assignments)

1

in_pdb
3RY3

No

YPO2660

16122866

putative solute-binding protein

525

Conserved Gene / Pathway

Phase 2: March 2008

3RY3

100%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP04478
(show subtarget assignments)

1

soluble

No

YPO2870

115348541

guaA

putative GMP synthase [Yersinia pestis C...

525

drug target; putative drug target function;

Phase 4: April 2009

1GPM

87.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP05306
(show subtarget assignments)

1

cloned

No

CD2786

126700402

cell surface protein [Clostridium diffic...

525

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP04093
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1907

218929023

irp5

yersiniabactin siderophore biosynthetic ...

525

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1MD9

47.8%

Yersinia pestis

Cellular processes

Cell division

IDP90973
(show subtarget assignments)

8

selected

No

AND4_00045

163803697

RTX toxin RtxA [Vibrio sp. AND4]

525

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Vibrio sp.

IDP92038
(show subtarget assignments)

8

selected

No

TGME49_034500

237839185

phenylalanyl tRNA synthetase isoform, pu...

525

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3L4G

47%

Toxoplasma gondii

IDP05074
(show subtarget assignments)

1

cloned

No

lmo0135

16802183

-

hypothetical protein lmo0135 [Listeria m...

524

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

32.4%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP01417
(show subtarget assignments)

1

soluble

No

VC1414

15641425

thermostable carboxypeptidase 1

524

Drug Target Function

Phase 2: March 2008

3DWC

44.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91530
(show subtarget assignments)

8

purified

No

VC1268

15641281

hypothetical protein VC1268 [Vibrio chol...

524

other biological interest / We have recently established that D-amino acids are important signal molecules t...

Community Requests

Vibrio cholerae

IDP90171
(show subtarget assignments)

8

cloned

No

AAM13460.1

20152999

CPXV013 CDS

CPXV013 protein

523

kelch-like protein

Community Requests

3HVE

10.1%

Cowpox virus

conserved hypothetical proteins

0

IDP91561
(show subtarget assignments)

8

purified

No

BAB33895

13359929

ECs0472

hypothetical protein [Escherichia coli O...

523

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP02611
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0111

47566431

M23/37 family peptidase [Bacillus anthra...

523

Drug target motif; Vaccine Target

Phase 3: June 2008

2GU1

10.1%

Bacillus anthracis

N/A

IDP90295
(show subtarget assignments)

8

cloned

No

TGME49_005290

211965425

dual-specificity phosphatase laforin, pu...

523

Human Lafora disease is one of five major progressive myoclonus epilepsies that ...

Community Requests

Toxoplasma gondii

IDP01413
(show subtarget assignments)

1

purified

No

VC1174

15641187

anthranilate synthase component I

523

Drug Target Function

Phase 2: March 2008

1I1Q

59.3%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP02659
(show subtarget assignments)

1

cloned

No

lmo0988

16803028

prfC

peptide chain release factor 3 [Listeria...

522

Predicted virulence-Regulation

Phase 3: June 2008

3TR5

48.5%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP05135
(show subtarget assignments)

1

soluble

No

CD0855

126698435

oppA

oligopeptide ABC transporter, substrate-...

522

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

33.1%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05181
(show subtarget assignments)

1

soluble

No

BA_4729

30259221

bacterial extracellular solute-binding p...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1UQW

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP91898
(show subtarget assignments)

8

selected

No

SpneCM_010100003105

298254588

amino acid ABC transporter, amino acid-b...

521

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3I6V

13.4%

Streptococcus pneumoniae

IDP05530
(show subtarget assignments)

1

cloned

No

CD1534

126699138

putative gamma-glutamyltranspeptidase [C...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NLZ

54.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs

IDP00440
(show subtarget assignments)

1

purified

No

YPO2208

16122436

trpE

anthranilate synthase component I

521

Conserved Gene / Pathway

Phase 2: March 2008

1I7Q

79.7%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP90285
(show subtarget assignments)

8

soluble

No

TGME49_083850

211966798

peptidyl-prolyl isomerase, putative [Tox...

521

The immunophilin TgFBCP57 uniquely contains domains for both immunosuppressant d...

Community Requests

1KT0

23.2%

Toxoplasma gondii

IDP02076
(show subtarget assignments)

1

soluble

No

STM3216

16766515

putative methyl-accepting chemotaxis pro...

521

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

28.6%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP91644
(show subtarget assignments)

8

purified

No

NP_215861

15608485

long-chain-fatty-acid--[acyl-carrier-pro...

521

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

3PBK

31.5%

Mycobacterium tuberculosis

IDP02163
(show subtarget assignments)

1

cloned

No

GBAA3914

47529205

phosphodiesterase [Bacillus anthracis st...

520

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

General

IDP91300
(show subtarget assignments)

8

soluble

No

STM1723

16765067

trpE

anthranilate synthase component I

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

99.8%

Salmonella enterica

IDP02463
(show subtarget assignments)

1

expressed

No

YPO1769

16122023

hpaB

4-hydroxyphenylacetate 3-monooxygenase [...

520

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2YYG

28.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Degradation

IDP91232
(show subtarget assignments)

8

expressed

No

NT04EC1776

26107995

trpE

Anthranilate synthase component I [Esche...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

89.6%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP04713
(show subtarget assignments)

1

purified

No

YPO0533

218927730

leuA

2-isopropylmalate synthase [Yersinia pes...

520

conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

36.3%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP91286
(show subtarget assignments)

8

expressed

No

SPA1154

56413352

trpE

anthranilate synthase component I [Salmo...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

99%

Salmonella enterica

IDP91223
(show subtarget assignments)

8

purified

No

SF1267

24112663

trpE

anthranilate synthase component I [Shige...

520

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

89.2%

Shigella flexneri

IDP91343
(show subtarget assignments)

8

expressed

No

VV2_0072

27366531

methyl-accepting chemotaxis protein [Vib...

519

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3ZX6

17.7%

Vibrio vulnificus

IDP05711
(show subtarget assignments)

1

soluble

No

BAS1732

49184745

-

oligopeptide ABC transporter, solute bin...

519

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

28.5%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP02550
(show subtarget assignments)

1

in_pdb
3RF0

Yes

YPO2837

16123032

ppx

exopolyphosphatase [Yersinia pestis CO92...

519

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1U6Z

76.3%

Yersinia pestis

Central intermediary metabolism

Phosphorus compounds

IDP05249
(show subtarget assignments)

1

soluble

No

BAS2289

49185298

-

hypothetical protein BAS2289 [Bacillus a...

512

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: General

IDP90353
(show subtarget assignments)

8

expressed

No

CT198

15604918

oppA_3

oligopeptide binding protein [Chlamydia ...

518

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1UIU

25.5%

Chlamydia trachomatis

IDP02230
(show subtarget assignments)

1

cloned

No

YPO0829

16121138

putative sulfatase [Yersinia pestis CO92...

517

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2QZU

40.2%

Yersinia pestis

Unknown function

Enzymes of unknown specificity

IDP00829
(show subtarget assignments)

1

purified

No

SACOL2515

57285199

gntK

gluconokinase

517

Drug Target Function

Phase 2: March 2008

3GBT

39.3%

Staphylococcus aureus

Energy metabolism

Sugars

IDP04497
(show subtarget assignments)

1

soluble

No

VC0768

9655215

GMP synthase [Vibrio cholerae O1 biovar ...

517

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

80.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04540
(show subtarget assignments)

1

purified

No

CPF_0511

110801291

sensor histidine kinase [Clostridium per...

516

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

18.2%

Clostridium perfringens

Signal transduction

Two-component systems

IDP05190
(show subtarget assignments)

1

cloned

No

CD0248

126697819

fliF

flagellar MS-ring protein [Clostridium d...

516

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04173
(show subtarget assignments)

1

expressed

No

VC2490

15642486

2-isopropylmalate synthase [Vibrio chole...

516

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RMJ

39%

Vibrio cholerae

Amino acid biosynthesis

Pyruvate family

IDP04526
(show subtarget assignments)

1

expressed

No

STM1637_1_516

16764981

putative inner membrane protein [Salmone...

516

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP02219
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1019c

56708108

guaA

bifunctional GMP synthase/glutamine amid...

516

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1GPM

61.1%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP05219
(show subtarget assignments)

1

cloned

No

CD3567

126701193

putative cell wall hydrolase [Clostridiu...

516

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Sporulation and germination

IDP04458
(show subtarget assignments)

1

soluble

No

YPO1466

115347220

conserved hypothetical protein [Yersinia...

516

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP02302
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0203c

56707367

purH

bifunctional phosphoribosylaminoimidazol...

515

Drug Target

Phase 3: June 2008

3ZZM

47.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP92118
(show subtarget assignments)

8

selected

No

TGME49_015480

237843139

adenosine/AMP deaminase domain containin...

515

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3OU8

21.7%

Toxoplasma gondii

IDP92023
(show subtarget assignments)

8

selected

No

TGME49_010260

237845081

glycerol-3-phosphate dehydrogenase, puta...

515

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1YJ8

33.2%

Toxoplasma gondii

IDP02033
(show subtarget assignments)

1

cloned

No

Cj1135

15792460

glycosyltransferase [Campylobacter jejun...

515

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

2Z86

14%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02117
(show subtarget assignments)

1

in_crystallization_trials

No

STM4356

16767602

yjeF

hypothetical protein STM4356 [Salmonella...

515

Conserved; Drug target functions

Phase 3: June 2008

2AX3

31.3%

Salmonella enterica

Unknown function

General

IDP05716
(show subtarget assignments)

1

soluble

No

BA_0692

30254291

conserved hypothetical protein [Bacillus...

515

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP90219
(show subtarget assignments)

8

expressed

No

MYXV_gp011

9633802

m008L

m008L, m8

515

contains kelch motifs, similar to MYX-L-m006R

Community Requests

2XN4

11.5%

Myxoma virus

unknown

0

IDP91925
(show subtarget assignments)

8

selected

No

SpneCM_010100003175

298254600

prfC

peptide chain release factor 3 [Streptoc...

514

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3TR5

48.1%

Streptococcus pneumoniae

IDP04556
(show subtarget assignments)

1

cloned

No

YPO3008

218930055

putative two-component sensor histidine ...

514

putative drug target function;

Phase 4: April 2009

2C2A

16%

Yersinia pestis

Regulatory functions

Other

IDP01679
(show subtarget assignments)

1

cloned

No

FTT0738

56707853

yjeF

carbohydrate kinase family protein (YjeF...

514

Conserved; Drug target functions

Phase 3: June 2008

2AX3

28%

Francisella tularensis

Energy metabolism

Sugars

IDP01930
(show subtarget assignments)

1

expressed

No

STM1578

16764922

narY

nitrate reductase 2 beta subunit [Salmon...

514

Conserved; Essential; Drug target functions

Phase 3: June 2008

1Q16

79%

Salmonella enterica

Energy metabolism

Anaerobic

IDP00342
(show subtarget assignments)

1

cloned

No

FTT1802c

56708788

trpE

anthranilate synthase component I

514

Drug Target Function

Phase 2: March 2008

1I1Q

51.1%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP90256
(show subtarget assignments)

8

crystallized

No

SAR0409

49482642

guaA

bifunctional GMP synthase/glutamine amid...

513

(From requestor) Identified potential S. aureus drug target. Would like to devel...

Community Requests

1GPM

51.2%

Staphylococcus aureus

IDP05122
(show subtarget assignments)

1

expressed

No

BA_3551

30258083

amyS

alpha-amylase [Bacillus anthracis str. A...

513

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VJS

68.6%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01802
(show subtarget assignments)

1

crystallized

No

FTT0062

56707241

atpA

F0F1 ATP synthase subunit alpha [Francis...

513

Conserved; Drug target functions

Phase 3: June 2008

3OAA

71%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP02593
(show subtarget assignments)

1

expressed

No

YPO3426

16123575

hofB

hypothetical protein YPO3426 [Yersinia p...

512

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

34.2%

Yersinia pestis

Cell envelope

Surface structures

IDP02108
(show subtarget assignments)

1

in_crystallization_trials

No

STM3680

16766965

aldB

aldehyde dehydrogenase B [Salmonella typ...

512

Conserved; Drug target functions

Phase 3: June 2008

1NZW

40.6%

Salmonella enterica

Energy metabolism

Other

IDP90183
(show subtarget assignments)

8

cloned

No

AAM13482.1

20153021

CPXV035 CDS

CPXV035 protein

512

kelch-like protein

Community Requests

2XN4

12.7%

Cowpox virus

conserved hypothetical proteins

0

IDP91697
(show subtarget assignments)

8

selected

No

NP_002341

4505055

LYN

tyrosine-protein kinase Lyn isoform A [H...

512

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2C0I

66.6%

Homo sapiens

IDP05355
(show subtarget assignments)

1

cloned

No

CD3506

126701130

hypothetical protein CD3506 [Clostridium...

512

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP00049
(show subtarget assignments)

0

work_stopped

No

BA_3355

30257898

thiol-activated cytolysin

512

Virulence

Phase 1: October 2007

3CQF

93.6%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01456
(show subtarget assignments)

1

purified

No

VC2406

15642403

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

512

Conserved Gene / Pathway

Phase 2: March 2008

1E8C

50.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90889
(show subtarget assignments)

8

cloned

No

VC0664

15640683

lysS

lysyl-tRNA synthetase [Vibrio cholerae O...

512

Predicted Essential

Community Requests

1E1O

58.8%

Vibrio cholerae

IDP02486
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4209

47529502

Ppx/GppA phosphatase family protein [Bac...

512

Conserved; Drug target functions

Phase 3: June 2008

3HI0

23%

Bacillus anthracis

Central intermediary metabolism

Phosphorus compounds

IDP02560
(show subtarget assignments)

1

cloned

No

GBAA0268

47777798

guaA

bifunctional GMP synthase/glutamine amid...

512

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPM

52.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90724
(show subtarget assignments)

8

expressed

No

Cj1719c

15793022

leuA

2-isopropylmalate synthase [Campylobacte...

511

Predicted Essential

Community Requests

3RMJ

37.6%

Campylobacter jejuni

IDP91106
(show subtarget assignments)

8

in_pdb
3QFK

Yes

SAOUHSC_00107

88193920

hypothetical protein SAOUHSC_00107 [Stap...

511

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3QFK

99.8%

Staphylococcus aureus

IDP90695
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1248

15792572

guaA

bifunctional GMP synthase/glutamine amid...

511

Predicted Essential

Community Requests

1GPM

51.8%

Campylobacter jejuni

IDP01186
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0298

81584380

Bifunctional purine biosynthesis protein...

511

Conserved Gene / Pathway

Phase 2: March 2008

3ZZM

44.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00569
(show subtarget assignments)

1

purified

No

YPO4016

16124139

hutH

histidine ammonia-lyase

510

Drug Target Function

Phase 2: March 2008

1GK2

77.5%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP90570
(show subtarget assignments)

8

in_pdb
4EHI

No

Cj0953c

15792282

purH

bifunctional phosphoribosylaminoimidazol...

510

Predicted Essential

Community Requests

3ZZM

39.2%

Campylobacter jejuni

IDP02285
(show subtarget assignments)

1

soluble

No

FTT0132

56707303

glpA

anaerobic glycerol-3-phosphate dehydroge...

510

Drug Target

Phase 3: June 2008

3DA1

33.1%

Francisella tularensis

Energy metabolism

Other

IDP02657
(show subtarget assignments)

1

cloned

No

lmo0203

16802249

mpl

Zinc metalloproteinase precursor [Lister...

510

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; Possible Vac...

Phase 3: June 2008

1BQB

27.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01217
(show subtarget assignments)

1

expressed

No

BA_3695

30258216

S-layer protein, putative

510

Drug Target Function

Phase 2: March 2008

3PYW

10.2%

Bacillus anthracis

Cell envelope

Surface structures

IDP90215
(show subtarget assignments)

8

expressed

No

MYXV_gp009

9633800

m006L

m006L, m6

509

contains kelch motifs, similar to MYX-L-m006R

Community Requests

1X2J

13.9%

Myxoma virus

unknown

0

IDP91399
(show subtarget assignments)

8

soluble

No

VV1_1028

27364461

threonine dehydratase [Vibrio vulnificus...

509

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1TDJ

70.1%

Vibrio vulnificus

IDP02753
(show subtarget assignments)

1

expressed

No

GBAA4662

47529960

nadB

L-aspartate oxidase [Bacillus anthracis ...

509

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CHU

37.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00177
(show subtarget assignments)

1

purified

No

YPO3007

16123186

-

putative membrane protein

509

Virulence

Phase 1: October 2007

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92116
(show subtarget assignments)

8

selected

No

TGME49_060680

237831887

DNA primase small subunit, putative [Tox...

509

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1G71

9.2%

Toxoplasma gondii

IDP04199
(show subtarget assignments)

1

cloned

No

CPF_2557

110800712

guaA

bifunctional GMP synthase/glutamine amid...

509

conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

52.3%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01119
(show subtarget assignments)

1

purified

No

BA_0344

30253882

ahpF

alkyl hydroperoxide reductase, F subunit...

508

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

55.7%

Bacillus anthracis

Cellular processes

Detoxification

IDP05328
(show subtarget assignments)

1

soluble

No

lmo2591

16804629

-

GW repeat-containing surface protein [Li...

508

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

17.7%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP00782
(show subtarget assignments)

1

cloned

No

SACOL0857

57284318

staphylocoagulase precursor, putative

508

Conserved Gene / Pathway

Phase 2: March 2008

2A1D

16.9%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP00754
(show subtarget assignments)

0

work_stopped

No

SACOL0095

57286644

spa

immunoglobulin G binding protein A precu...

508

Conserved Gene / Pathway

Phase 2: March 2008

1BDC

11.6%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP05140
(show subtarget assignments)

1

soluble

No

BAS0382

49183410

-

prolyl-tRNA synthetase [Bacillus anthrac...

508

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H4Q

48.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP92073
(show subtarget assignments)

8

selected

No

TGME49_088860

237838049

ruvB-like 2 protein, putative [Toxoplasm...

508

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2XSZ

49.2%

Toxoplasma gondii