Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01208 (show subtarget assignments)	1	expressed	No	BA_2638	30257255		glycosyl transferase, putative	387	Essential Gene	Phase 2: March 2008	2IYA	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01209 (show subtarget assignments)	1	soluble	No	BA_2650	30257267		penicillin-binding protein	340	Drug Target Function	Phase 2: March 2008	3TG9	53.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01210 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2805	30257409		glycosyl hydrolase, family 25, putative ...	268	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	61.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01211 (show subtarget assignments)	1	crystallized	No	BA_2958	30257549		chorismate mutase/phospho-2-dehydro-3-de...	358	Drug Target Function	Phase 2: March 2008	3NVT	69.8%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01212 (show subtarget assignments)	1	expressed	No	BA_3024	30257611		glycosyl transferase, group 2 family pro...	490	Essential Gene	Phase 2: March 2008	3E25	9.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01213 (show subtarget assignments)	1	expressed	No	BA_3251	30257808		3-oxoacyl-(acyl-carrier-protein) synthas...	329	Drug Target Function	Phase 2: March 2008	2EBD	34.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01214 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3460	30257999	cfa	cyclopropane-fatty-acyl-phospholipid syn...	390	Drug Target Function	Phase 2: March 2008	1TPY	25.1%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01215 (show subtarget assignments)	1	expressed	No	BA_3506	30258044		penicillin-binding protein, putative	345	Drug Target Function	Phase 2: March 2008	2QMI	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01216 (show subtarget assignments)	1	expressed	No	BA_3577	30258105		glycosyl transferase, group 1 family pro...	270	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01217 (show subtarget assignments)	1	expressed	No	BA_3695	30258216		S-layer protein, putative	510	Drug Target Function	Phase 2: March 2008	3PYW	10.2%	Bacillus anthracis	Cell envelope	Surface structures

IDP01218 (show subtarget assignments)	1	expressed	No	BA_3712	73919984		Histidine ammonia-lyase (Histidase)	505	Drug Target Function	Phase 2: March 2008	1GK2	42%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP01219 (show subtarget assignments)	1	purified	No	BA_3767	30258283		prophage LambdaBa01, N-acetylmuramoyl-L-...	310	Drug Target Function	Phase 2: March 2008	2L47	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01220 (show subtarget assignments)	1	purified	No	BA_3983	30258492	ffH	signal recognition particle protein	449	Conserved Gene / Pathway	Phase 2: March 2008	2XXA	51.9%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01221 (show subtarget assignments)	1	expressed	No	BA_3990	30258499	fabD	malonyl CoA-acyl carrier protein transac...	314	Drug Target Function	Phase 2: March 2008	1MLA	44.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01222 (show subtarget assignments)	1	purified	No	BA_4049	33301352		UDP-N-acetylglucosamine--N-acetylmuramyl...	364	Drug Target Function	Phase 2: March 2008	1F0K	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01223 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4051	60390084		UDP-N-acetylmuramoylalanine--D-glutamate...	450	Conserved Gene / Pathway	Phase 2: March 2008	3LK7	52.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01225 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4139	61211625		Phosphopantetheine adenylyltransferase (...	163	Drug Target Function	Phase 2: March 2008	1O6B	71.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01226 (show subtarget assignments)	0	work_stopped	No	BA_4187	39931064		Peptide deformylase 2 (PDF 2) (Polypepti...	184	Drug Target Function	Phase 2: March 2008	2OKL	96.2%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP01227 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4268	30258770	ptsH-1	phosphocarrier protein HPr	87	Conserved Gene / Pathway	Phase 2: March 2008	1Y4Y	72.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01228 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4283	30258785		peptidyl-prolyl cis-trans isomerase, cyc...	145	Conserved Gene / Pathway	Phase 2: March 2008	1AK4	42.1%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01229 (show subtarget assignments)	1	soluble	No	BA_4540	52782922		Protein grpE (HSP-70 cofactor)	188	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	34.9%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01230 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4638	33300883		Adenine phosphoribosyltransferase (APRT)...	170	Drug Target Function	Phase 2: March 2008	2DY0	52.4%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01231 (show subtarget assignments)	1	purified	No	BA_4684	30259179	mreB	rod shape-determining protein MreB	339	Drug Target Function	Phase 2: March 2008	1JCE	52.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01232 (show subtarget assignments)	1	purified	No	BA_5112	30259596	menF	menaquinone-specific isochorismate synth...	464	Drug Target Function	Phase 2: March 2008	3H9M	22.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01233 (show subtarget assignments)	1	purified	No	BA_5335	30259811	estA	carboxylesterase	246	Drug Target Function	Phase 2: March 2008	1R1D	79.3%	Bacillus anthracis	Cellular processes	Detoxification

IDP01234 (show subtarget assignments)	0	work_stopped	No	BA_5509	30259969		UDP-N-acetylglucosamine 2-epimerase	371	Drug Target Function	Phase 2: March 2008	3BEO	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01235 (show subtarget assignments)	1	purified	No	BA_5512	30259972	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	427	Drug Target Function	Phase 2: March 2008	3OJL	62.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01236 (show subtarget assignments)	1	expressed	No	BA_5514	30259974		glycosyl transferase, group 1 family pro...	550	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01237 (show subtarget assignments)	1	purified	No	BA_5563	46396830		Glucose-specific phosphotransferase enzy...	165	Drug Target Function	Phase 2: March 2008	1GGR	46.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01238 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5635	30260086		lipoate-protein ligase A, putative	281	Drug Target Function	Phase 2: March 2008	2P5I	60.1%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01240 (show subtarget assignments)	1	cloned	No	BA_1069	30254800	pbpF	penicillin-binding protein 1	705	Drug Target Function	Phase 2: March 2008	2OLU	27.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01241 (show subtarget assignments)	1	expressed	No	BA_1474	30255405		penicillin-binding protein	673	Drug Target Function	Phase 2: March 2008	2JCH	28.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01242 (show subtarget assignments)	1	soluble	No	BA_1572	30255873		penicillin-binding protein	897	Drug Target Function	Phase 2: March 2008	2OLU	27.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243 (show subtarget assignments)	1	cloned	No	BA_2345	30256982		penicillin-binding protein 1A	820	Drug Target Function	Phase 2: March 2008	2OLU	29.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01247 (show subtarget assignments)	1	soluble	No	BA_3214	30257780		penicillin-binding protein, putative	691	Drug Target Function	Phase 2: March 2008	2QMI	14.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01248 (show subtarget assignments)	1	soluble	No	BA_3554	30258085		penicillin-binding protein, putative	377	Drug Target Function	Phase 2: March 2008	3TG9	23.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250 (show subtarget assignments)	1	cloned	No	BA_4497	30259003		penicillin-binding protein	706	Drug Target Function	Phase 2: March 2008	2WAF	33%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251 (show subtarget assignments)	1	cloned	No	BA_4606	30259106		penicillin-binding protein	584	Drug Target Function	Phase 2: March 2008	3OC2	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01252 (show subtarget assignments)	1	cloned	No	BA_5623	30260075		penicillin-binding protein	683	Drug Target Function	Phase 2: March 2008	3UDF	28.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01253 (show subtarget assignments)	1	cloned	No	BA_2575	30257197		penicillin-binding protein, putative	481	Drug Target Function	Phase 2: March 2008	2QMI	20%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01254 (show subtarget assignments)	1	in_pdb 4ECM 3HL3	Yes	BA_1228	30255177		glucose-1-phosphate thymidylyltransferas...	245	Conserved Gene / Pathway	Phase 2: March 2008	3HL3	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01255 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5132	30259616	yugI	general stress protein 13	114	Conserved Gene / Pathway	Phase 2: March 2008	2K4K	53.3%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP01256 (show subtarget assignments)	0	work_stopped	No	BA_1232	30255181	fabI	enoyl-(acyl-carrier-protein) reductase	256	Drug Target Function	Phase 2: March 2008	2QIO	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01257 (show subtarget assignments)	1	expressed	No	BA_5677	30260125		glycosyl transferase, group 2 family pro...	267	Drug Target Function	Phase 2: March 2008	3BCV	11.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01258 (show subtarget assignments)	1	soluble	No	BA_2238	30256883	pbpC	penicillin-binding protein 3	661	Drug Target Function	Phase 2: March 2008	1MWR	34.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01300 (show subtarget assignments)	1	in_pdb 3F0I	Yes	VC2165	15642164		arsenate reductase	116	Conserved Gene / Pathway	Phase 2: March 2008	3F0I	100%	Vibrio cholerae	Cellular processes	Detoxification

IDP01301 (show subtarget assignments)	1	expressed	No	VC0170	15640200		peptide ABC transporter, ATP-binding pro...	571	Conserved Gene / Pathway	Phase 2: March 2008	1YQT	22.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01302 (show subtarget assignments)	1	soluble	No	VC0263	15640292		galactosyl-transferase, putative	184	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01303 (show subtarget assignments)	1	purified	No	VC0573	15640595		ubiquinol--cytochrome c reductase, iron-...	197	Conserved Gene / Pathway	Phase 2: March 2008	2FYN	37.6%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01304 (show subtarget assignments)	1	in_pdb 3HHO	Yes	VC0751	15640770	hscB	co-chaperone HscB	171	Conserved Gene / Pathway	Phase 2: March 2008	3HHO	100%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01305 (show subtarget assignments)	1	soluble	No	VC1064	15641077		lipoprotein-related protein	143	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01306 (show subtarget assignments)	1	purified	No	VC1281	15641294		PTS system, cellobiose-specific IIB comp...	101	Conserved Gene / Pathway	Phase 2: March 2008	2L2Q	40.6%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01307 (show subtarget assignments)	1	soluble	No	VC1283	15641296		PTS system, cellobiose-specific IIA comp...	111	Conserved Gene / Pathway	Phase 2: March 2008	1WCR	45.9%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01308 (show subtarget assignments)	1	expressed	No	VC1516	15641524		iron-sulfur cluster-binding protein	553	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Energy metabolism	Electron transport

IDP01309 (show subtarget assignments)	1	purified	No	VC2078	15642078		ferrous iron transport protein A	76	Drug Target Function	Phase 2: March 2008	2K5I	34.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01310 (show subtarget assignments)	1	purified	No	VC2251	15642249		outer membrane protein OmpH	169	Conserved Gene / Pathway	Phase 2: March 2008	1SG2	30.2%	Vibrio cholerae	Cell envelope	Other

IDP01311 (show subtarget assignments)	1	soluble	No	VCA0726	15601482		molybdenum ABC transporter, periplasmic ...	254	Conserved Gene / Pathway	Phase 2: March 2008	1AMF	37.8%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01312 (show subtarget assignments)	1	crystallized	No	VCA0819	15601574	groES	co-chaperonin GroES	96	Conserved Gene / Pathway	Phase 2: March 2008	1AON	65.6%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01313 (show subtarget assignments)	1	purified	No	VCA0446	15601209		haemagglutinin	63	Virulence Associated Factor	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01314 (show subtarget assignments)	1	cloned	No	VCA0594	15601353		hemolysin	93	Virulence Associated Factor	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01315 (show subtarget assignments)	1	cloned	No	VC0942	15640958		hypothetical protein VC0942	117	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01316 (show subtarget assignments)	1	in_crystallization_trials	No	VC1616	15641624		glutaredoxin, putative	77	Conserved Gene / Pathway	Phase 2: March 2008	2KLX	32.5%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01317 (show subtarget assignments)	1	soluble	No	VC0966	15640982		phosphocarrier protein HPr	85	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	75.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01318 (show subtarget assignments)	1	in_pdb 3IQ1	No	VC0139	15640170		DPS family protein	156	Conserved Gene / Pathway	Phase 2: March 2008	3IQ1	100%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP01319 (show subtarget assignments)	1	soluble	No	VC0312	15640339	fre	FMN reductase	236	Conserved Gene / Pathway	Phase 2: March 2008	1QFJ	48.3%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01320 (show subtarget assignments)	1	purified	No	VC1883	15641885		ABC transporter, ATP-binding protein	228	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	45.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01321 (show subtarget assignments)	1	purified	No	VC2082	15642082		zinc ABC transporter, ATP-binding protei...	262	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01322 (show subtarget assignments)	1	purified	No	VC2296	15642294		bolA protein	106	Conserved Gene / Pathway	Phase 2: March 2008	2DHM	50.9%	Vibrio cholerae	Cellular processes	Other

IDP01323 (show subtarget assignments)	1	cloned	No	VC2633	15642628		fimbrial assembly protein PilN, putative...	196	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Surface structures

IDP01324 (show subtarget assignments)	1	cloned	No	VCA0910	15601664		tonB1 protein	249	Conserved Gene / Pathway	Phase 2: March 2008	2GRX	27.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01325 (show subtarget assignments)	1	in_pdb 3EER 3I07 3LUS	Yes	VCA1006	15601759		organic hydroperoxide resistance protein...	145	Conserved Gene / Pathway	Phase 2: March 2008	3EER	100%	Vibrio cholerae	Cellular processes	Detoxification

IDP01326 (show subtarget assignments)	1	purified	No	VCA0953	15601706		peptidyl-prolyl cis-trans isomerase C	92	Conserved Gene / Pathway	Phase 2: March 2008	1JNS	65.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01327 (show subtarget assignments)	1	purified	No	VC0418	15640445	maf	Maf-like protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	40%	Vibrio cholerae	Cellular processes	Cell division

IDP01328 (show subtarget assignments)	1	purified	No	VC0443	15640470	ksgA	dimethyladenosine transferase	282	Conserved Gene / Pathway	Phase 2: March 2008	3TPZ	61.7%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01329 (show subtarget assignments)	1	in_pdb 3HJB	No	VC0374	15640401	pgi	glucose-6-phosphate isomerase	550	Drug Target Function	Phase 2: March 2008	3HJB	99.8%	Vibrio cholerae	Energy metabolism	Glycolysis/gluconeogenesis

IDP01330 (show subtarget assignments)	1	purified	No	VC0557	15640579		S-ribosylhomocysteinase	172	Conserved Gene / Pathway	Phase 2: March 2008	1J6W	71.5%	Vibrio cholerae	Cellular processes	Other

IDP01331 (show subtarget assignments)	1	purified	No	VC0589	15640610		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	28.9%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01332 (show subtarget assignments)	1	purified	No	VC0639	15640659		phosphoglucomutase/phosphomannomutase fa...	446	Drug Target Function	Phase 2: March 2008	3PDK	46.6%	Vibrio cholerae	Energy metabolism	Sugars

IDP01333 (show subtarget assignments)	1	purified	No	VC0726	15640745		phosphate ABC transporter, ATP-binding p...	273	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	33%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01334 (show subtarget assignments)	1	in_pdb 3IV8 3EGJ	Yes	VC0994	15641009	nagA	N-acetylglucosamine-6-phosphate deacetyl...	378	Drug Target Function	Phase 2: March 2008	3EGJ	100%	Vibrio cholerae	Central intermediary metabolism	Amino sugars

IDP01335 (show subtarget assignments)	1	soluble	No	VC1144	15641157	clpA	ATP-dependent Clp protease ATP-binding s...	756	Drug Target Function	Phase 2: March 2008	1KSF	77.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01336 (show subtarget assignments)	1	purified	No	VC1428	15641439	potA	putrescine/spermidine ABC transporter AT...	377	Conserved Gene / Pathway	Phase 2: March 2008	2D62	41.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01337 (show subtarget assignments)	1	in_pdb 3E9A	No	VC2175	15642174		2-dehydro-3-deoxyphosphooctonate aldolas...	283	Conserved Gene / Pathway	Phase 2: March 2008	3E9A	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01338 (show subtarget assignments)	1	in_crystallization_trials	No	VC2261	15642259		methionine aminopeptidase	280	Drug Target Function	Community Interest	1MAT	57.5%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP01339 (show subtarget assignments)	1	purified	No	VC2397	15642394		cell division protein FtsZ	398	Conserved Gene / Pathway	Phase 2: March 2008	2VAW	58.6%	Vibrio cholerae	Cellular processes	Cell division

IDP01340 (show subtarget assignments)	1	expressed	No	VCA0073	15600844		phosphate ABC transporter, ATP-binding p...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	37.1%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01341 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0687	15601444	fbpC	ferric transporter ATP-binding subunit	351	Conserved Gene / Pathway	Phase 2: March 2008	1V43	38.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01342 (show subtarget assignments)	1	soluble	No	VC1960	15641962		septum site-determining protein MinD	276	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	73.6%	Vibrio cholerae	Cellular processes	Cell division

IDP01343 (show subtarget assignments)	1	cloned	No	VC2649	15642644	cysE	serine acetyltransferase	273	Drug Target Function	Phase 2: March 2008	1T3D	72.2%	Vibrio cholerae	Amino acid biosynthesis	Serine family

IDP01344 (show subtarget assignments)	1	crystallized	No	VCA1025	15601778	nagB	glucosamine-6-phosphate deaminase	266	Drug Target Function	Phase 2: March 2008	1CD5	79.3%	Vibrio cholerae	Energy metabolism	Sugars

IDP01345 (show subtarget assignments)	1	soluble	No	VC0824	15640841	tpx	tagD protein	164	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01346 (show subtarget assignments)	1	cloned	No	VC1621	15641628		agglutination protein	445	Conserved Gene / Pathway	Phase 2: March 2008	2VDD	24.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01347 (show subtarget assignments)	1	purified	No	VC2421	15642418		N-acetyl-anhydromuranmyl-L-alanine amida...	181	Conserved Gene / Pathway	Phase 2: March 2008	1J3G	63%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01348 (show subtarget assignments)	0	work_stopped	No	VCA0219	15600988		haemolysin	741	Conserved Gene / Pathway	Phase 2: March 2008	1XEZ	94.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01208
(show subtarget assignments)

1

expressed

No

BA_2638

30257255

glycosyl transferase, putative

387

Essential Gene

Phase 2: March 2008

2IYA

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01209
(show subtarget assignments)

1

soluble

No

BA_2650

30257267

penicillin-binding protein

340

Drug Target Function

Phase 2: March 2008

3TG9

53.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01210
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2805

30257409

glycosyl hydrolase, family 25, putative ...

268

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

61.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01211
(show subtarget assignments)

1

crystallized

No

BA_2958

30257549

chorismate mutase/phospho-2-dehydro-3-de...

358

Drug Target Function

Phase 2: March 2008

3NVT

69.8%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01212
(show subtarget assignments)

1

expressed

No

BA_3024

30257611

glycosyl transferase, group 2 family pro...

490

Essential Gene

Phase 2: March 2008

3E25

9.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01213
(show subtarget assignments)

1

expressed

No

BA_3251

30257808

3-oxoacyl-(acyl-carrier-protein) synthas...

329

Drug Target Function

Phase 2: March 2008

2EBD

34.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01214
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3460

30257999

cfa

cyclopropane-fatty-acyl-phospholipid syn...

390

Drug Target Function

Phase 2: March 2008

1TPY

25.1%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01215
(show subtarget assignments)

1

expressed

No

BA_3506

30258044

penicillin-binding protein, putative

345

Drug Target Function

Phase 2: March 2008

2QMI

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01216
(show subtarget assignments)

1

expressed

No

BA_3577

30258105

glycosyl transferase, group 1 family pro...

270

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01217
(show subtarget assignments)

1

expressed

No

BA_3695

30258216

S-layer protein, putative

510

Drug Target Function

Phase 2: March 2008

3PYW

10.2%

Bacillus anthracis

Cell envelope

Surface structures

IDP01218
(show subtarget assignments)

1

expressed

No

BA_3712

73919984

Histidine ammonia-lyase (Histidase)

505

Drug Target Function

Phase 2: March 2008

1GK2

42%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP01219
(show subtarget assignments)

1

purified

No

BA_3767

30258283

prophage LambdaBa01, N-acetylmuramoyl-L-...

310

Drug Target Function

Phase 2: March 2008

2L47

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01220
(show subtarget assignments)

1

purified

No

BA_3983

30258492

ffH

signal recognition particle protein

449

Conserved Gene / Pathway

Phase 2: March 2008

2XXA

51.9%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01221
(show subtarget assignments)

1

expressed

No

BA_3990

30258499

fabD

malonyl CoA-acyl carrier protein transac...

314

Drug Target Function

Phase 2: March 2008

1MLA

44.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01222
(show subtarget assignments)

1

purified

No

BA_4049

33301352

UDP-N-acetylglucosamine--N-acetylmuramyl...

364

Drug Target Function

Phase 2: March 2008

1F0K

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01223
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4051

60390084

UDP-N-acetylmuramoylalanine--D-glutamate...

450

Conserved Gene / Pathway

Phase 2: March 2008

3LK7

52.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01225
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4139

61211625

Phosphopantetheine adenylyltransferase (...

163

Drug Target Function

Phase 2: March 2008

1O6B

71.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01226
(show subtarget assignments)

0

work_stopped

No

BA_4187

39931064

Peptide deformylase 2 (PDF 2) (Polypepti...

184

Drug Target Function

Phase 2: March 2008

2OKL

96.2%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP01227
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4268

30258770

ptsH-1

phosphocarrier protein HPr

87

Conserved Gene / Pathway

Phase 2: March 2008

1Y4Y

72.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01228
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4283

30258785

peptidyl-prolyl cis-trans isomerase, cyc...

145

Conserved Gene / Pathway

Phase 2: March 2008

1AK4

42.1%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01229
(show subtarget assignments)

1

soluble

No

BA_4540

52782922

Protein grpE (HSP-70 cofactor)

188

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

34.9%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01230
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4638

33300883

Adenine phosphoribosyltransferase (APRT)...

170

Drug Target Function

Phase 2: March 2008

2DY0

52.4%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01231
(show subtarget assignments)

1

purified

No

BA_4684

30259179

mreB

rod shape-determining protein MreB

339

Drug Target Function

Phase 2: March 2008

1JCE

52.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01232
(show subtarget assignments)

1

purified

No

BA_5112

30259596

menF

menaquinone-specific isochorismate synth...

464

Drug Target Function

Phase 2: March 2008

3H9M

22.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01233
(show subtarget assignments)

1

purified

No

BA_5335

30259811

estA

carboxylesterase

246

Drug Target Function

Phase 2: March 2008

1R1D

79.3%

Bacillus anthracis

Cellular processes

Detoxification

IDP01234
(show subtarget assignments)

0

work_stopped

No

BA_5509

30259969

UDP-N-acetylglucosamine 2-epimerase

371

Drug Target Function

Phase 2: March 2008

3BEO

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01235
(show subtarget assignments)

1

purified

No

BA_5512

30259972

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

427

Drug Target Function

Phase 2: March 2008

3OJL

62.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01236
(show subtarget assignments)

1

expressed

No

BA_5514

30259974

glycosyl transferase, group 1 family pro...

550

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01237
(show subtarget assignments)

1

purified

No

BA_5563

46396830

Glucose-specific phosphotransferase enzy...

165

Drug Target Function

Phase 2: March 2008

1GGR

46.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01238
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5635

30260086

lipoate-protein ligase A, putative

281

Drug Target Function

Phase 2: March 2008

2P5I

60.1%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01240
(show subtarget assignments)

1

cloned

No

BA_1069

30254800

pbpF

penicillin-binding protein 1

705

Drug Target Function

Phase 2: March 2008

2OLU

27.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01241
(show subtarget assignments)

1

expressed

No

BA_1474

30255405

penicillin-binding protein

673

Drug Target Function

Phase 2: March 2008

2JCH

28.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01242
(show subtarget assignments)

1

soluble

No

BA_1572

30255873

penicillin-binding protein

897

Drug Target Function

Phase 2: March 2008

2OLU

27.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243
(show subtarget assignments)

1

cloned

No

BA_2345

30256982

penicillin-binding protein 1A

820

Drug Target Function

Phase 2: March 2008

2OLU

29.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01247
(show subtarget assignments)

1

soluble

No

BA_3214

30257780

penicillin-binding protein, putative

691

Drug Target Function

Phase 2: March 2008

2QMI

14.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01248
(show subtarget assignments)

1

soluble

No

BA_3554

30258085

penicillin-binding protein, putative

377

Drug Target Function

Phase 2: March 2008

3TG9

23.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250
(show subtarget assignments)

1

cloned

No

BA_4497

30259003

penicillin-binding protein

706

Drug Target Function

Phase 2: March 2008

2WAF

33%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251
(show subtarget assignments)

1

cloned

No

BA_4606

30259106

penicillin-binding protein

584

Drug Target Function

Phase 2: March 2008

3OC2

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01252
(show subtarget assignments)

1

cloned

No

BA_5623

30260075

penicillin-binding protein

683

Drug Target Function

Phase 2: March 2008

3UDF

28.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01253
(show subtarget assignments)

1

cloned

No

BA_2575

30257197

penicillin-binding protein, putative

481

Drug Target Function

Phase 2: March 2008

2QMI

20%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01254
(show subtarget assignments)

1

in_pdb
4ECM
3HL3

Yes

BA_1228

30255177

glucose-1-phosphate thymidylyltransferas...

245

Conserved Gene / Pathway

Phase 2: March 2008

3HL3

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01255
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5132

30259616

yugI

general stress protein 13

114

Conserved Gene / Pathway

Phase 2: March 2008

2K4K

53.3%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP01256
(show subtarget assignments)

0

work_stopped

No

BA_1232

30255181

fabI

enoyl-(acyl-carrier-protein) reductase

256

Drug Target Function

Phase 2: March 2008

2QIO

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01257
(show subtarget assignments)

1

expressed

No

BA_5677

30260125

glycosyl transferase, group 2 family pro...

267

Drug Target Function

Phase 2: March 2008

3BCV

11.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01258
(show subtarget assignments)

1

soluble

No

BA_2238

30256883

pbpC

penicillin-binding protein 3

661

Drug Target Function

Phase 2: March 2008

1MWR

34.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01300
(show subtarget assignments)

1

in_pdb
3F0I

Yes

VC2165

15642164

arsenate reductase

116

Conserved Gene / Pathway

Phase 2: March 2008

3F0I

100%

Vibrio cholerae

Cellular processes

Detoxification

IDP01301
(show subtarget assignments)

1

expressed

No

VC0170

15640200

peptide ABC transporter, ATP-binding pro...

571

Conserved Gene / Pathway

Phase 2: March 2008

1YQT

22.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01302
(show subtarget assignments)

1

soluble

No

VC0263

15640292

galactosyl-transferase, putative

184

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01303
(show subtarget assignments)

1

purified

No

VC0573

15640595

ubiquinol--cytochrome c reductase, iron-...

197

Conserved Gene / Pathway

Phase 2: March 2008

2FYN

37.6%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01304
(show subtarget assignments)

1

in_pdb
3HHO

Yes

VC0751

15640770

hscB

co-chaperone HscB

171

Conserved Gene / Pathway

Phase 2: March 2008

3HHO

100%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01305
(show subtarget assignments)

1

soluble

No

VC1064

15641077

lipoprotein-related protein

143

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01306
(show subtarget assignments)

1

purified

No

VC1281

15641294

PTS system, cellobiose-specific IIB comp...

101

Conserved Gene / Pathway

Phase 2: March 2008

2L2Q

40.6%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01307
(show subtarget assignments)

1

soluble

No

VC1283

15641296

PTS system, cellobiose-specific IIA comp...

111

Conserved Gene / Pathway

Phase 2: March 2008

1WCR

45.9%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01308
(show subtarget assignments)

1

expressed

No

VC1516

15641524

iron-sulfur cluster-binding protein

553

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Energy metabolism

Electron transport

IDP01309
(show subtarget assignments)

1

purified

No

VC2078

15642078

ferrous iron transport protein A

76

Drug Target Function

Phase 2: March 2008

2K5I

34.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01310
(show subtarget assignments)

1

purified

No

VC2251

15642249

outer membrane protein OmpH

169

Conserved Gene / Pathway

Phase 2: March 2008

1SG2

30.2%

Vibrio cholerae

Cell envelope

Other

IDP01311
(show subtarget assignments)

1

soluble

No

VCA0726

15601482

molybdenum ABC transporter, periplasmic ...

254

Conserved Gene / Pathway

Phase 2: March 2008

1AMF

37.8%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01312
(show subtarget assignments)

1

crystallized

No

VCA0819

15601574

groES

co-chaperonin GroES

96

Conserved Gene / Pathway

Phase 2: March 2008

1AON

65.6%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01313
(show subtarget assignments)

1

purified

No

VCA0446

15601209

haemagglutinin

63

Virulence Associated Factor

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01314
(show subtarget assignments)

1

cloned

No

VCA0594

15601353

hemolysin

93

Virulence Associated Factor

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01315
(show subtarget assignments)

1

cloned

No

VC0942

15640958

hypothetical protein VC0942

117

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01316
(show subtarget assignments)

1

in_crystallization_trials

No

VC1616

15641624

glutaredoxin, putative

77

Conserved Gene / Pathway

Phase 2: March 2008

2KLX

32.5%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01317
(show subtarget assignments)

1

soluble

No

VC0966

15640982

phosphocarrier protein HPr

85

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

75.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01318
(show subtarget assignments)

1

in_pdb
3IQ1

No

VC0139

15640170

DPS family protein

156

Conserved Gene / Pathway

Phase 2: March 2008

3IQ1

100%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP01319
(show subtarget assignments)

1

soluble

No

VC0312

15640339

fre

FMN reductase

236

Conserved Gene / Pathway

Phase 2: March 2008

1QFJ

48.3%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01320
(show subtarget assignments)

1

purified

No

VC1883

15641885

ABC transporter, ATP-binding protein

228

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

45.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01321
(show subtarget assignments)

1

purified

No

VC2082

15642082

zinc ABC transporter, ATP-binding protei...

262

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01322
(show subtarget assignments)

1

purified

No

VC2296

15642294

bolA protein

106

Conserved Gene / Pathway

Phase 2: March 2008

2DHM

50.9%

Vibrio cholerae

Cellular processes

Other

IDP01323
(show subtarget assignments)

1

cloned

No

VC2633

15642628

fimbrial assembly protein PilN, putative...

196

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Surface structures

IDP01324
(show subtarget assignments)

1

cloned

No

VCA0910

15601664

tonB1 protein

249

Conserved Gene / Pathway

Phase 2: March 2008

2GRX

27.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01325
(show subtarget assignments)

1

in_pdb
3EER
3I07
3LUS

Yes

VCA1006

15601759

organic hydroperoxide resistance protein...

145

Conserved Gene / Pathway

Phase 2: March 2008

3EER

100%

Vibrio cholerae

Cellular processes

Detoxification

IDP01326
(show subtarget assignments)

1

purified

No

VCA0953

15601706

peptidyl-prolyl cis-trans isomerase C

92

Conserved Gene / Pathway

Phase 2: March 2008

1JNS

65.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01327
(show subtarget assignments)

1

purified

No

VC0418

15640445

maf

Maf-like protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

40%

Vibrio cholerae

Cellular processes

Cell division

IDP01328
(show subtarget assignments)

1

purified

No

VC0443

15640470

ksgA

dimethyladenosine transferase

282

Conserved Gene / Pathway

Phase 2: March 2008

3TPZ

61.7%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01329
(show subtarget assignments)

1

in_pdb
3HJB

No

VC0374

15640401

pgi

glucose-6-phosphate isomerase

550

Drug Target Function

Phase 2: March 2008

3HJB

99.8%

Vibrio cholerae

Energy metabolism

Glycolysis/gluconeogenesis

IDP01330
(show subtarget assignments)

1

purified

No

VC0557

15640579

S-ribosylhomocysteinase

172

Conserved Gene / Pathway

Phase 2: March 2008

1J6W

71.5%

Vibrio cholerae

Cellular processes

Other

IDP01331
(show subtarget assignments)

1

purified

No

VC0589

15640610

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

28.9%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01332
(show subtarget assignments)

1

purified

No

VC0639

15640659

phosphoglucomutase/phosphomannomutase fa...

446

Drug Target Function

Phase 2: March 2008

3PDK

46.6%

Vibrio cholerae

Energy metabolism

Sugars

IDP01333
(show subtarget assignments)

1

purified

No

VC0726

15640745

phosphate ABC transporter, ATP-binding p...

273

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

33%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01334
(show subtarget assignments)

1

in_pdb
3IV8
3EGJ

Yes

VC0994

15641009

nagA

N-acetylglucosamine-6-phosphate deacetyl...

378

Drug Target Function

Phase 2: March 2008

3EGJ

100%

Vibrio cholerae

Central intermediary metabolism

Amino sugars

IDP01335
(show subtarget assignments)

1

soluble

No

VC1144

15641157

clpA

ATP-dependent Clp protease ATP-binding s...

756

Drug Target Function

Phase 2: March 2008

1KSF

77.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01336
(show subtarget assignments)

1

purified

No

VC1428

15641439

potA

putrescine/spermidine ABC transporter AT...

377

Conserved Gene / Pathway

Phase 2: March 2008

2D62

41.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01337
(show subtarget assignments)

1

in_pdb
3E9A

No

VC2175

15642174

2-dehydro-3-deoxyphosphooctonate aldolas...

283

Conserved Gene / Pathway

Phase 2: March 2008

3E9A

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01338
(show subtarget assignments)

1

in_crystallization_trials

No

VC2261

15642259

methionine aminopeptidase

280

Drug Target Function

Community Interest

1MAT

57.5%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP01339
(show subtarget assignments)

1

purified

No

VC2397

15642394

cell division protein FtsZ

398

Conserved Gene / Pathway

Phase 2: March 2008

2VAW

58.6%

Vibrio cholerae

Cellular processes

Cell division

IDP01340
(show subtarget assignments)

1

expressed

No

VCA0073

15600844

phosphate ABC transporter, ATP-binding p...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

37.1%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01341
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0687

15601444

fbpC

ferric transporter ATP-binding subunit

351

Conserved Gene / Pathway

Phase 2: March 2008

1V43

38.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01342
(show subtarget assignments)

1

soluble

No

VC1960

15641962

septum site-determining protein MinD

276

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

73.6%

Vibrio cholerae

Cellular processes

Cell division

IDP01343
(show subtarget assignments)

1

cloned

No

VC2649

15642644

cysE

serine acetyltransferase

273

Drug Target Function

Phase 2: March 2008

1T3D

72.2%

Vibrio cholerae

Amino acid biosynthesis

Serine family

IDP01344
(show subtarget assignments)

1

crystallized

No

VCA1025

15601778

nagB

glucosamine-6-phosphate deaminase

266

Drug Target Function

Phase 2: March 2008

1CD5

79.3%

Vibrio cholerae

Energy metabolism

Sugars

IDP01345
(show subtarget assignments)

1

soluble

No

VC0824

15640841

tpx

tagD protein

164

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01346
(show subtarget assignments)

1

cloned

No

VC1621

15641628

agglutination protein

445

Conserved Gene / Pathway

Phase 2: March 2008

2VDD

24.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01347
(show subtarget assignments)

1

purified

No

VC2421

15642418

N-acetyl-anhydromuranmyl-L-alanine amida...

181

Conserved Gene / Pathway

Phase 2: March 2008

1J3G

63%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01348
(show subtarget assignments)

0

work_stopped

No

VCA0219

15600988

haemolysin

741

Conserved Gene / Pathway

Phase 2: March 2008

1XEZ

94.7%

Vibrio cholerae

Cellular processes

Pathogenesis

Targets