Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00078 (show subtarget assignments)	0	work_stopped	No	NTL01ST3606	16422278	rfaF	ADP-heptose; LPS heptosyltransferase 1	348		Phase 1: October 2007	1PSW	91.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91406 (show subtarget assignments)	8	cloned	No	VV1_0798	27364247		ADP-heptose--LPS heptosyltransferase II ...	352	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1PSW	50.3%	Vibrio vulnificus

IDP90918 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0057	16120410	rfaF	ADP-heptose:LPS heptosyltransferase II [...	354	Predicted Essential	Community Requests	1PSW	72.3%	Yersinia pestis

IDP02508 (show subtarget assignments)	1	cloned	No	lmo1847	16803887		hypothetical protein lmo1847 [Listeria m...	310	Known virulence-Invasion; PMID:12496198	Phase 3: June 2008	1PSZ	52.3%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP04605 (show subtarget assignments)	1	in_crystallization_trials	No	BAS3689	49186688		ribosomal biogenesis GTPase [Bacillus an...	296	Proposed to be essential proteins	Phase 4: April 2009	1PUJ	67.2%	Bacillus anthracis

IDP00617 (show subtarget assignments)	1	expressed	No	SACOL1880	57284800	lukD	leukotoxin LukD	327	Virulence Associated Factor	Phase 2: March 2008	1PVL	75.5%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP04394 (show subtarget assignments)	1	cloned	No	CPF_2117	110800208	spoVD	stage V sporulation protein D [Clostridi...	695	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	24.8%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00794 (show subtarget assignments)	1	cloned	No	SACOL1194	57284479	pbp1	penicillin-binding protein 1	744	Drug Target Function	Phase 2: March 2008	1PYY	30.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92560 (show subtarget assignments)	8	selected	No	1PYY_A	37927671		Chain A, Double Mutant Pbp2x T338aM339F ...	702	potential drug target / Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...	Community Requests	1PYY	100%	Streptococcus pneumoniae

IDP04190 (show subtarget assignments)	1	cloned	No	CPF_0544	110800679	spoVD	stage V sporulation protein D [Clostridi...	721	conserved gene; putative drug target function;	Phase 4: April 2009	1PYY	27.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01501 (show subtarget assignments)	1	expressed	No	VCA0946	15601699		maltose/maltodextrin transporter ATP-bin...	373	Conserved Gene / Pathway	Phase 2: March 2008	1Q12	67.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01728 (show subtarget assignments)	1	expressed	No	CBU_0840	29541434	asnB-2	asparagine synthetase B, glutamine-hydro...	637	Conserved; Drug target functions	Phase 3: June 2008	1Q15	13%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP01930 (show subtarget assignments)	1	expressed	No	STM1578	16764922	narY	nitrate reductase 2 beta subunit [Salmon...	514	Conserved; Essential; Drug target functions	Phase 3: June 2008	1Q16	79%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02350 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2977	16123158	glk	glucokinase [Yersinia pestis CO92]	323	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1Q18	78.6%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP00423 (show subtarget assignments)	1	soluble	No	YPO1019	16121320	ptrA	protease III precursor	962	Drug Target Function	Phase 2: March 2008	1Q2L	61.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01384 (show subtarget assignments)	1	purified	No	VC0554	15640576		protease, insulinase family/protease, in...	952	Drug Target Function	Phase 2: March 2008	1Q2L	19.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00739 (show subtarget assignments)	1	diffraction	No	SACOL1063	57284433		acetyltransferase, GNAT family	144	Drug Target Function	Phase 2: March 2008	1Q2Y	40.3%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP01388 (show subtarget assignments)	1	soluble	No	VC0608	15640628		iron(III) ABC transporter, periplasmic i...	352	Conserved Gene / Pathway	Phase 2: March 2008	1Q35	55.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02572 (show subtarget assignments)	1	soluble	No	lmo1939	16803978	cmk	hypothetical protein lmo1939 [Listeria m...	224	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	1Q3T	59.4%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP05295 (show subtarget assignments)	1	cloned	No	CD1816	126699424	cmk	cytidylate kinase [Clostridium difficile...	216	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Q3T	44.4%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01198 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1518	59798071		Cytidylate kinase (CK) (Cytidine monopho...	225	Conserved Gene / Pathway	Phase 2: March 2008	1Q3T	53.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP91662 (show subtarget assignments)	8	selected	No	NP_004351	4757960	CDH1	cadherin-1 preproprotein [Homo sapiens]	882	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1Q55	57.5%	Homo sapiens

IDP01034 (show subtarget assignments)	0	work_stopped	No	STM4089	16767355	menG	ribonuclease activity regulator protein ...	161	Conserved Gene / Pathway	Phase 2: March 2008	1Q5X	97.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP91062 (show subtarget assignments)	8	cloned	No	YPO0195	16120534	fkpA	peptidyl-prolyl cis-trans isomerase	266	virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...	Community Requests	1Q6U	70.3%	Yersinia pestis

IDP90294 (show subtarget assignments)	8	expressed	No	TGME49_113230	211962198		eukaryotic translation initiation factor...	347	Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...	Community Requests	1Q8K	40.3%	Toxoplasma gondii

IDP91589 (show subtarget assignments)	8	expressed	No	BAB41266	13699967	ermA	rRNA methylase [Staphylococcus aureus su...	243	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1QAM	56.8%	Staphylococcus aureus

IDP91784 (show subtarget assignments)	8	soluble	No	SA1480	15927234	ermA	rRNA methylase Erm(A) [Staphylococcus au...	243	drug resistance / rRNA methylase (macrolide-lincosamide-streptogramin B resistance protein)	Community Requests	1QAM	56.8%	Staphylococcus aureus

IDP00555 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3424	16123573	nadC	quinolinate phosphoribosyltransferase	302	Conserved Gene / Pathway	Phase 2: March 2008	1QAP	72.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP90842 (show subtarget assignments)	8	selected	No	S0108	30061675	nadC	quinolinate phosphoribosyltransferase [S...	297	Predicted Essential	Community Requests	1QAP	85.9%	Shigella flexneri

IDP00041 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2409	30257040		chloramphenicol acetyltransferase	216	Virulence	Phase 1: October 2007	1QCA	41.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00880 (show subtarget assignments)	0	work_stopped	No	STM0534	16763914	purE	phosphoribosylaminoimidazole carboxylase...	169	Conserved Gene / Pathway	Phase 2: March 2008	1QCZ	95.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02213 (show subtarget assignments)	1	expressed	No	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01875 (show subtarget assignments)	1	expressed	No	GBAA0069	47525323	pabA-1	para-aminobenzoate/anthranilate synthase...	195	Conserved; Essential; Drug target functions	Phase 3: June 2008	1QDL	45.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01619 (show subtarget assignments)	1	expressed	No	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	Phase 3: June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00847 (show subtarget assignments)	1	expressed	No	SACOL1404	57284558	trpG	anthranilate synthase, glutamine amidotr...	188	Drug Target Function	Phase 2: March 2008	1QDL	34.2%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP02548 (show subtarget assignments)	1	cloned	No	Cj0861c	15792199	pabA	para-aminobenzoate synthase glutamine am...	188	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1QDL	44%	Campylobacter jejuni	Cell envelope	Other

IDP00799 (show subtarget assignments)	1	expressed	No	SACOL1403	57284557	trpE	anthranilate synthase component I	468	Drug Target Function	Phase 2: March 2008	1QDL	33.3%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP00412 (show subtarget assignments)	1	expressed	No	YPO0169	16120512	pabA	para-aminobenzoate synthase component II...	191	Drug Target Function	Phase 2: March 2008	1QDL	46.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00350 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1633	16803673	trpE	anthranilate synthase component I	454	Drug Target Function	Phase 2: March 2008	1QDL	35.7%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP00337 (show subtarget assignments)	1	expressed	No	FTT0946	56708043	trpG	anthranilate synthase component II	184	Drug Target Function	Phase 2: March 2008	1QDL	40.7%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP00330 (show subtarget assignments)	1	purified	No	Cj0345	15791713	trpE	putative anthranilate synthase component...	416	Drug Target Function	Phase 2: March 2008	1QDL	32%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP00316 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP01196 (show subtarget assignments)	1	expressed	No	BA_1248	30255197	trpE	anthranilate synthase component I	471	Drug Target Function	Phase 2: March 2008	1QDL	38.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP01142 (show subtarget assignments)	1	expressed	No	BA_1249	30255198	pabA-2	para-aminobenzoate synthase glutamine am...	195	Drug Target Function	Phase 2: March 2008	1QDL	43.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP05687 (show subtarget assignments)	1	cloned	No	lmo1520	16803560	hisS	histidyl-tRNA synthetase [Listeria monoc...	425	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1QE0	53.4%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90770 (show subtarget assignments)	8	soluble	No	YPO2433	16122654	thrS	threonyl-tRNA synthetase [Yersinia pesti...	642	Predicted Essential	Community Requests	1QF6	88.3%	Yersinia pestis

IDP90813 (show subtarget assignments)	8	in_crystallization_trials	No	VCA0287	15601053		threonyl-tRNA synthetase [Vibrio cholera...	642	Predicted Essential	Community Requests	1QF6	75.6%	Vibrio cholerae

IDP92018 (show subtarget assignments)	8	selected	No	TGME49_100260	237844903		threonyl-tRNA synthetase, putative [Toxo...	844	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QF6	30.7%	Toxoplasma gondii

IDP90668 (show subtarget assignments)	8	purified	No	Cj0206	15791593	thrS	threonyl-tRNA synthetase [Campylobacter ...	602	Predicted Essential	Community Requests	1QF6	43%	Campylobacter jejuni

IDP01319 (show subtarget assignments)	1	soluble	No	VC0312	15640339	fre	FMN reductase	236	Conserved Gene / Pathway	Phase 2: March 2008	1QFJ	48.3%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02418 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1279c	15792603		fibronectin domain-containing lipoprotei...	411	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	1QR4	10.9%	Campylobacter jejuni	Transcription	DNA-dependent RNA polymerase

IDP05420 (show subtarget assignments)	1	soluble	No	lmo0066	16802114	-	hypothetical protein lmo0066 [Listeria m...	604	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1QS1	15.7%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP02200 (show subtarget assignments)	1	cloned	No	CBU_1103	29541677		transglycosylase, Slt family [Coxiella b...	425	Conserved; Drug target functions	Phase 3: June 2008	1QSA	16.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01777 (show subtarget assignments)	1	cloned	No	CBU_0313	29540926		transglycosylase, Slt family [Coxiella b...	487	Conserved; Drug target functions	Phase 3: June 2008	1QSA	9.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05102 (show subtarget assignments)	1	cloned	No	CD1130	126698724		putative transglycosylase [Clostridium d...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1QSA	28.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00171 (show subtarget assignments)	1	cloned	No	YPO0452	16120781	-	putative soluble lytic murein transglyco...	639	Similar to Essential SALTY	Phase 1: October 2007	1QSA	61.8%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01394 (show subtarget assignments)	1	soluble	No	VC0700	15640719		soluble lytic murein transglycosylase	648	Drug Target Function	Phase 2: March 2008	1QSA	33.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01046 (show subtarget assignments)	1	expressed	No	STM3138	16766438		putative methyl-accepting chemotaxis pro...	352	Conserved Gene / Pathway	Phase 2: March 2008	1QU7	16.8%	Salmonella enterica	Cellular processes	Other

IDP04443 (show subtarget assignments)	1	cloned	No	YPO0506	218927704	clpB	putative Clp ATPase [Yersinia pestis CO9...	867	virulence factor; putative drug target function;	Phase 4: April 2009	1QVR	36.3%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01772 (show subtarget assignments)	1	cloned	No	YPO3599	16123741	clpB2	Clp ATPase [Yersinia pestis CO92]	867	Drug target motif; CD; Drug target functions	Phase 3: June 2008	1QVR	33.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01651 (show subtarget assignments)	1	cloned	No	YPO2946	16123129	clpB5	Clp ATPase [Yersinia pestis CO92]	891	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	1QVR	35.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04143 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3275	115348911	clpB	Clp ATPase [Yersinia pestis CO92]	857	drug target; putative drug target function;	Phase 4: April 2009	1QVR	57.1%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91438 (show subtarget assignments)	8	soluble	No	VV1_0482	27363946		ClpB protein [Vibrio vulnificus CMCP6]	857	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1QVR	56%	Vibrio vulnificus

IDP90100 (show subtarget assignments)	8	expressed	No	ZZZ_0016				849	This protein is a component of a type VI secretion system of enteroaggregative E...	Community Requests	1QVR	36.8%	Escherichia coli

IDP00175 (show subtarget assignments)	1	soluble	No	YPO1471	16121746	-	putative ATPase subunit of ATP-dependent...	880	Virulence	Phase 1: October 2007	1QVR	36.9%	Yersinia pestis

IDP02671 (show subtarget assignments)	1	selected	No	lmo0997	16803037	clpE	ATP-dependent protease [Listeria monocyt...	724	Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs	Phase 3: June 2008	1QVR	46.3%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP92128 (show subtarget assignments)	8	selected	No	TGME49_082200	237844257		clpB protein, putative [Toxoplasma gondi...	970	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QVR	38.7%	Toxoplasma gondii

IDP92126 (show subtarget assignments)	8	selected	No	TGME49_068650	237832521		clp ATP-binding chain B1, putative [Toxo...	929	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QVR	48.9%	Toxoplasma gondii

IDP92125 (show subtarget assignments)	8	selected	No	TGME49_057990	237831451		heat shock protein, putative [Toxoplasma...	921	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QVR	46.4%	Toxoplasma gondii

IDP00697 (show subtarget assignments)	1	purified	No	SACOL2563	57285245		ATP-dependent Clp protease, putative	701	Drug Target Function	Phase 2: March 2008	1QVR	43.1%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02556 (show subtarget assignments)	1	soluble	No	FTT1769c	56708764	clpB	ClpB protein [Francisella tularensis sub...	859	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1QVR	55.3%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01480 (show subtarget assignments)	1	cloned	No	VCA0116	15600887		clpB protein	869	Drug Target Function	Phase 2: March 2008	1QVR	36.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00663 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0979	57285852	clpB	ATP-dependent Clp protease, ATP-binding ...	869	Drug Target Function	Phase 2: March 2008	1QVR	54.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02116 (show subtarget assignments)	1	soluble	No	CBU_0094	29540716	clpB	clpB protein [Coxiella burnetii RSA 493]...	859	Conserved; Drug target functions	Phase 3: June 2008	1QVR	58.2%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02057 (show subtarget assignments)	1	soluble	No	Cj1311	15792634	neuA2	acylneuraminate cytidylyltransferase [Ca...	232	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	1QWJ	26.3%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02009 (show subtarget assignments)	1	soluble	No	STM2925	16766231	nlpD	lipoprotein NlpD [Salmonella typhimurium...	377	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1QWY	23.3%	Salmonella enterica	Cell envelope	Other

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP00970 (show subtarget assignments)	1	soluble	No	STM1682	16765025	tpx	thiol peroxidase	168	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	87.5%	Salmonella enterica	Cellular processes	Detoxification

IDP01345 (show subtarget assignments)	1	soluble	No	VC0824	15640841	tpx	tagD protein	164	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP04646 (show subtarget assignments)	1	soluble	No	FTT1085	56708168		hypothetical protein FTT_1085 [Francisel...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1QXN	9.3%	Francisella tularensis

IDP91258 (show subtarget assignments)	8	soluble	No	NT02SA1455	14247237	aroC	chorismate synthase [Staphylococcus aure...	388	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1QXO	56.7%	Staphylococcus aureus	Amino acid biosynthesis: Aromatic amino acid family

IDP05341 (show subtarget assignments)	1	cloned	No	lmo1928	16803967	aroF	chorismate synthase [Listeria monocytoge...	388	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1QXO	63.1%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP01199 (show subtarget assignments)	1	purified	No	BA_1537	67460530		Chorismate synthase 1 (5-enolpyruvylshik...	390	Drug Target Function	Phase 2: March 2008	1QXO	59%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00053 (show subtarget assignments)	1	soluble	No	BA_3536	30258071		phenazine biosynthesis protein, PhzF fam...	285	Virulence	Phase 1: October 2007	1QY9	31.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01473 (show subtarget assignments)	1	soluble	No	VC2653	15642648		preprotein translocase subunit SecB	154	Conserved Gene / Pathway	Phase 2: March 2008	1QYN	66.2%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP91436 (show subtarget assignments)	8	cloned	No	VV1_0484	27363948	rluD	23S rRNA pseudouridine synthase D [Vibri...	325	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1QYU	69.8%	Vibrio vulnificus

IDP90655 (show subtarget assignments)	8	expressed	No	Cj1346c	15792669	dxr	1-deoxy-D-xylulose 5-phosphate reductois...	356	Predicted Essential	Community Requests	1R0K	36.2%	Campylobacter jejuni

IDP00781 (show subtarget assignments)	1	expressed	No	SACOL0845	57284307	est	carboxylesterase	246	Conserved Gene / Pathway	Phase 2: March 2008	1R1D	57.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP01233 (show subtarget assignments)	1	purified	No	BA_5335	30259811	estA	carboxylesterase	246	Drug Target Function	Phase 2: March 2008	1R1D	79.3%	Bacillus anthracis	Cellular processes	Detoxification

IDP00724 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1822	57286255	arsR	arsenical resistance operon repressor	104	Conserved Gene / Pathway	Phase 2: March 2008	1R1T	31.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP04048 (show subtarget assignments)	1	in_crystallization_trials	No	VC1112	15641125		biotin synthase [Vibrio cholerae O1 biov...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1R30	69.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02046 (show subtarget assignments)	1	soluble	No	CBU_1007	29541589	bioB	biotin synthase [Coxiella burnetii RSA 4...	321	Conserved; Drug target functions	Phase 3: June 2008	1R30	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04719 (show subtarget assignments)	1	expressed	No	YPO1151	218928315	bioB	biotin synthase [Yersinia pestis CO92]	345	conserved gene; putative drug target function;	Phase 4: April 2009	1R30	83.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01958 (show subtarget assignments)	1	expressed	No	FTT0937c	56708034	bioB	biotin synthase [Francisella tularensis ...	313	Drug Target	Phase 3: June 2008	1R30	49.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90631 (show subtarget assignments)	8	expressed	No	YPO2526	16122745		acyl-CoA thioester hydrolase YfbB [Yersi...	272	Predicted Essential	Community Requests	1R3D	42.3%	Yersinia pestis

IDP91776 (show subtarget assignments)	8	in_crystallization_trials	No	ACM47288	222159815	vanXD	D,D-dipeptidase VanXD [Enterococcus faec...	202	drug resistance / D,D-dipeptidase	Community Requests	1R44	70.3%	Enterococcus faecium

IDP00078
(show subtarget assignments)

0

work_stopped

No

NTL01ST3606

16422278

rfaF

ADP-heptose; LPS heptosyltransferase 1

348

Phase 1: October 2007

1PSW

91.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91406
(show subtarget assignments)

8

cloned

No

VV1_0798

27364247

ADP-heptose--LPS heptosyltransferase II ...

352

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1PSW

50.3%

Vibrio vulnificus

IDP90918
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0057

16120410

rfaF

ADP-heptose:LPS heptosyltransferase II [...

354

Predicted Essential

Community Requests

1PSW

72.3%

Yersinia pestis

IDP02508
(show subtarget assignments)

1

cloned

No

lmo1847

16803887

hypothetical protein lmo1847 [Listeria m...

310

Known virulence-Invasion; PMID:12496198

Phase 3: June 2008

1PSZ

52.3%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP04605
(show subtarget assignments)

1

in_crystallization_trials

No

BAS3689

49186688

ribosomal biogenesis GTPase [Bacillus an...

296

Proposed to be essential proteins

Phase 4: April 2009

1PUJ

67.2%

Bacillus anthracis

IDP00617
(show subtarget assignments)

1

expressed

No

SACOL1880

57284800

lukD

leukotoxin LukD

327

Virulence Associated Factor

Phase 2: March 2008

1PVL

75.5%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP04394
(show subtarget assignments)

1

cloned

No

CPF_2117

110800208

spoVD

stage V sporulation protein D [Clostridi...

695

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

24.8%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00794
(show subtarget assignments)

1

cloned

No

SACOL1194

57284479

pbp1

penicillin-binding protein 1

744

Drug Target Function

Phase 2: March 2008

1PYY

30.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92560
(show subtarget assignments)

8

selected

No

1PYY_A

37927671

Chain A, Double Mutant Pbp2x T338aM339F ...

702

potential drug target / Pptase, FactorXa, HCV NS3/NS4A, Trypsin and Elastase/Subtilisin (see below)] and...

Community Requests

1PYY

100%

Streptococcus pneumoniae

IDP04190
(show subtarget assignments)

1

cloned

No

CPF_0544

110800679

spoVD

stage V sporulation protein D [Clostridi...

721

conserved gene; putative drug target function;

Phase 4: April 2009

1PYY

27.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01501
(show subtarget assignments)

1

expressed

No

VCA0946

15601699

maltose/maltodextrin transporter ATP-bin...

373

Conserved Gene / Pathway

Phase 2: March 2008

1Q12

67.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01728
(show subtarget assignments)

1

expressed

No

CBU_0840

29541434

asnB-2

asparagine synthetase B, glutamine-hydro...

637

Conserved; Drug target functions

Phase 3: June 2008

1Q15

13%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP01930
(show subtarget assignments)

1

expressed

No

STM1578

16764922

narY

nitrate reductase 2 beta subunit [Salmon...

514

Conserved; Essential; Drug target functions

Phase 3: June 2008

1Q16

79%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02350
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2977

16123158

glk

glucokinase [Yersinia pestis CO92]

323

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1Q18

78.6%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP00423
(show subtarget assignments)

1

soluble

No

YPO1019

16121320

ptrA

protease III precursor

962

Drug Target Function

Phase 2: March 2008

1Q2L

61.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01384
(show subtarget assignments)

1

purified

No

VC0554

15640576

protease, insulinase family/protease, in...

952

Drug Target Function

Phase 2: March 2008

1Q2L

19.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00739
(show subtarget assignments)

1

diffraction

No

SACOL1063

57284433

acetyltransferase, GNAT family

144

Drug Target Function

Phase 2: March 2008

1Q2Y

40.3%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP01388
(show subtarget assignments)

1

soluble

No

VC0608

15640628

iron(III) ABC transporter, periplasmic i...

352

Conserved Gene / Pathway

Phase 2: March 2008

1Q35

55.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02572
(show subtarget assignments)

1

soluble

No

lmo1939

16803978

cmk

hypothetical protein lmo1939 [Listeria m...

224

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

1Q3T

59.4%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP05295
(show subtarget assignments)

1

cloned

No

CD1816

126699424

cmk

cytidylate kinase [Clostridium difficile...

216

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Q3T

44.4%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01198
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1518

59798071

Cytidylate kinase (CK) (Cytidine monopho...

225

Conserved Gene / Pathway

Phase 2: March 2008

1Q3T

53.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP91662
(show subtarget assignments)

8

selected

No

NP_004351

4757960

CDH1

cadherin-1 preproprotein [Homo sapiens]

882

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1Q55

57.5%

Homo sapiens

IDP01034
(show subtarget assignments)

0

work_stopped

No

STM4089

16767355

menG

ribonuclease activity regulator protein ...

161

Conserved Gene / Pathway

Phase 2: March 2008

1Q5X

97.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP91062
(show subtarget assignments)

8

cloned

No

YPO0195

16120534

fkpA

peptidyl-prolyl cis-trans isomerase

266

virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...

Community Requests

1Q6U

70.3%

Yersinia pestis

IDP90294
(show subtarget assignments)

8

expressed

No

TGME49_113230

211962198

eukaryotic translation initiation factor...

347

Under stress conditions, the initiation factor 2a (TgIF2a) is phosphorylated to ...

Community Requests

1Q8K

40.3%

Toxoplasma gondii

IDP91589
(show subtarget assignments)

8

expressed

No

BAB41266

13699967

ermA

rRNA methylase [Staphylococcus aureus su...

243

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1QAM

56.8%

Staphylococcus aureus

IDP91784
(show subtarget assignments)

8

soluble

No

SA1480

15927234

ermA

rRNA methylase Erm(A) [Staphylococcus au...

243

drug resistance / rRNA methylase (macrolide-lincosamide-streptogramin B resistance protein)

Community Requests

1QAM

56.8%

Staphylococcus aureus

IDP00555
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3424

16123573

nadC

quinolinate phosphoribosyltransferase

302

Conserved Gene / Pathway

Phase 2: March 2008

1QAP

72.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP90842
(show subtarget assignments)

8

selected

No

S0108

30061675

nadC

quinolinate phosphoribosyltransferase [S...

297

Predicted Essential

Community Requests

1QAP

85.9%

Shigella flexneri

IDP00041
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2409

30257040

chloramphenicol acetyltransferase

216

Virulence

Phase 1: October 2007

1QCA

41.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00880
(show subtarget assignments)

0

work_stopped

No

STM0534

16763914

purE

phosphoribosylaminoimidazole carboxylase...

169

Conserved Gene / Pathway

Phase 2: March 2008

1QCZ

95.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02213
(show subtarget assignments)

1

expressed

No

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01875
(show subtarget assignments)

1

expressed

No

GBAA0069

47525323

pabA-1

para-aminobenzoate/anthranilate synthase...

195

Conserved; Essential; Drug target functions

Phase 3: June 2008

1QDL

45.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01619
(show subtarget assignments)

1

expressed

No

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

Phase 3: June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00847
(show subtarget assignments)

1

expressed

No

SACOL1404

57284558

trpG

anthranilate synthase, glutamine amidotr...

188

Drug Target Function

Phase 2: March 2008

1QDL

34.2%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP02548
(show subtarget assignments)

1

cloned

No

Cj0861c

15792199

pabA

para-aminobenzoate synthase glutamine am...

188

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1QDL

44%

Campylobacter jejuni

Cell envelope

Other

IDP00799
(show subtarget assignments)

1

expressed

No

SACOL1403

57284557

trpE

anthranilate synthase component I

468

Drug Target Function

Phase 2: March 2008

1QDL

33.3%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP00412
(show subtarget assignments)

1

expressed

No

YPO0169

16120512

pabA

para-aminobenzoate synthase component II...

191

Drug Target Function

Phase 2: March 2008

1QDL

46.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00350
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1633

16803673

trpE

anthranilate synthase component I

454

Drug Target Function

Phase 2: March 2008

1QDL

35.7%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP00337
(show subtarget assignments)

1

expressed

No

FTT0946

56708043

trpG

anthranilate synthase component II

184

Drug Target Function

Phase 2: March 2008

1QDL

40.7%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP00330
(show subtarget assignments)

1

purified

No

Cj0345

15791713

trpE

putative anthranilate synthase component...

416

Drug Target Function

Phase 2: March 2008

1QDL

32%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP00316
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP01196
(show subtarget assignments)

1

expressed

No

BA_1248

30255197

trpE

anthranilate synthase component I

471

Drug Target Function

Phase 2: March 2008

1QDL

38.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP01142
(show subtarget assignments)

1

expressed

No

BA_1249

30255198

pabA-2

para-aminobenzoate synthase glutamine am...

195

Drug Target Function

Phase 2: March 2008

1QDL

43.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP05687
(show subtarget assignments)

1

cloned

No

lmo1520

16803560

hisS

histidyl-tRNA synthetase [Listeria monoc...

425

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1QE0

53.4%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90770
(show subtarget assignments)

8

soluble

No

YPO2433

16122654

thrS

threonyl-tRNA synthetase [Yersinia pesti...

642

Predicted Essential

Community Requests

1QF6

88.3%

Yersinia pestis

IDP90813
(show subtarget assignments)

8

in_crystallization_trials

No

VCA0287

15601053

threonyl-tRNA synthetase [Vibrio cholera...

642

Predicted Essential

Community Requests

1QF6

75.6%

Vibrio cholerae

IDP92018
(show subtarget assignments)

8

selected

No

TGME49_100260

237844903

threonyl-tRNA synthetase, putative [Toxo...

844

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QF6

30.7%

Toxoplasma gondii

IDP90668
(show subtarget assignments)

8

purified

No

Cj0206

15791593

thrS

threonyl-tRNA synthetase [Campylobacter ...

602

Predicted Essential

Community Requests

1QF6

43%

Campylobacter jejuni

IDP01319
(show subtarget assignments)

1

soluble

No

VC0312

15640339

fre

FMN reductase

236

Conserved Gene / Pathway

Phase 2: March 2008

1QFJ

48.3%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02418
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1279c

15792603

fibronectin domain-containing lipoprotei...

411

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

1QR4

10.9%

Campylobacter jejuni

Transcription

DNA-dependent RNA polymerase

IDP05420
(show subtarget assignments)

1

soluble

No

lmo0066

16802114

-

hypothetical protein lmo0066 [Listeria m...

604

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1QS1

15.7%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP02200
(show subtarget assignments)

1

cloned

No

CBU_1103

29541677

transglycosylase, Slt family [Coxiella b...

425

Conserved; Drug target functions

Phase 3: June 2008

1QSA

16.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01777
(show subtarget assignments)

1

cloned

No

CBU_0313

29540926

transglycosylase, Slt family [Coxiella b...

487

Conserved; Drug target functions

Phase 3: June 2008

1QSA

9.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05102
(show subtarget assignments)

1

cloned

No

CD1130

126698724

putative transglycosylase [Clostridium d...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1QSA

28.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00171
(show subtarget assignments)

1

cloned

No

YPO0452

16120781

-

putative soluble lytic murein transglyco...

639

Similar to Essential SALTY

Phase 1: October 2007

1QSA

61.8%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01394
(show subtarget assignments)

1

soluble

No

VC0700

15640719

soluble lytic murein transglycosylase

648

Drug Target Function

Phase 2: March 2008

1QSA

33.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01046
(show subtarget assignments)

1

expressed

No

STM3138

16766438

putative methyl-accepting chemotaxis pro...

352

Conserved Gene / Pathway

Phase 2: March 2008

1QU7

16.8%

Salmonella enterica

Cellular processes

Other

IDP04443
(show subtarget assignments)

1

cloned

No

YPO0506

218927704

clpB

putative Clp ATPase [Yersinia pestis CO9...

867

virulence factor; putative drug target function;

Phase 4: April 2009

1QVR

36.3%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01772
(show subtarget assignments)

1

cloned

No

YPO3599

16123741

clpB2

Clp ATPase [Yersinia pestis CO92]

867

Drug target motif; CD; Drug target functions

Phase 3: June 2008

1QVR

33.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01651
(show subtarget assignments)

1

cloned

No

YPO2946

16123129

clpB5

Clp ATPase [Yersinia pestis CO92]

891

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

1QVR

35.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04143
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3275

115348911

clpB

Clp ATPase [Yersinia pestis CO92]

857

drug target; putative drug target function;

Phase 4: April 2009

1QVR

57.1%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91438
(show subtarget assignments)

8

soluble

No

VV1_0482

27363946

ClpB protein [Vibrio vulnificus CMCP6]

857

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1QVR

56%

Vibrio vulnificus

IDP90100
(show subtarget assignments)

8

expressed

No

ZZZ_0016

849

This protein is a component of a type VI secretion system of enteroaggregative E...

Community Requests

1QVR

36.8%

Escherichia coli

IDP00175
(show subtarget assignments)

1

soluble

No

YPO1471

16121746

-

putative ATPase subunit of ATP-dependent...

880

Virulence

Phase 1: October 2007

1QVR

36.9%

Yersinia pestis

IDP02671
(show subtarget assignments)

1

selected

No

lmo0997

16803037

clpE

ATP-dependent protease [Listeria monocyt...

724

Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs

Phase 3: June 2008

1QVR

46.3%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP92128
(show subtarget assignments)

8

selected

No

TGME49_082200

237844257

clpB protein, putative [Toxoplasma gondi...

970

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QVR

38.7%

Toxoplasma gondii

IDP92126
(show subtarget assignments)

8

selected

No

TGME49_068650

237832521

clp ATP-binding chain B1, putative [Toxo...

929

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QVR

48.9%

Toxoplasma gondii

IDP92125
(show subtarget assignments)

8

selected

No

TGME49_057990

237831451

heat shock protein, putative [Toxoplasma...

921

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QVR

46.4%

Toxoplasma gondii

IDP00697
(show subtarget assignments)

1

purified

No

SACOL2563

57285245

ATP-dependent Clp protease, putative

701

Drug Target Function

Phase 2: March 2008

1QVR

43.1%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02556
(show subtarget assignments)

1

soluble

No

FTT1769c

56708764

clpB

ClpB protein [Francisella tularensis sub...

859

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1QVR

55.3%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01480
(show subtarget assignments)

1

cloned

No

VCA0116

15600887

clpB protein

869

Drug Target Function

Phase 2: March 2008

1QVR

36.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00663
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0979

57285852

clpB

ATP-dependent Clp protease, ATP-binding ...

869

Drug Target Function

Phase 2: March 2008

1QVR

54.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02116
(show subtarget assignments)

1

soluble

No

CBU_0094

29540716

clpB

clpB protein [Coxiella burnetii RSA 493]...

859

Conserved; Drug target functions

Phase 3: June 2008

1QVR

58.2%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02057
(show subtarget assignments)

1

soluble

No

Cj1311

15792634

neuA2

acylneuraminate cytidylyltransferase [Ca...

232

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

1QWJ

26.3%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02009
(show subtarget assignments)

1

soluble

No

STM2925

16766231

nlpD

lipoprotein NlpD [Salmonella typhimurium...

377

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1QWY

23.3%

Salmonella enterica

Cell envelope

Other

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP00970
(show subtarget assignments)

1

soluble

No

STM1682

16765025

tpx

thiol peroxidase

168

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

87.5%

Salmonella enterica

Cellular processes

Detoxification

IDP01345
(show subtarget assignments)

1

soluble

No

VC0824

15640841

tpx

tagD protein

164

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP04646
(show subtarget assignments)

1

soluble

No

FTT1085

56708168

hypothetical protein FTT_1085 [Francisel...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1QXN

9.3%

Francisella tularensis

IDP91258
(show subtarget assignments)

8

soluble

No

NT02SA1455

14247237

aroC

chorismate synthase [Staphylococcus aure...

388

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1QXO

56.7%

Staphylococcus aureus

Amino acid biosynthesis: Aromatic amino acid family

IDP05341
(show subtarget assignments)

1

cloned

No

lmo1928

16803967

aroF

chorismate synthase [Listeria monocytoge...

388

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1QXO

63.1%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP01199
(show subtarget assignments)

1

purified

No

BA_1537

67460530

Chorismate synthase 1 (5-enolpyruvylshik...

390

Drug Target Function

Phase 2: March 2008

1QXO

59%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00053
(show subtarget assignments)

1

soluble

No

BA_3536

30258071

phenazine biosynthesis protein, PhzF fam...

285

Virulence

Phase 1: October 2007

1QY9

31.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01473
(show subtarget assignments)

1

soluble

No

VC2653

15642648

preprotein translocase subunit SecB

154

Conserved Gene / Pathway

Phase 2: March 2008

1QYN

66.2%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP91436
(show subtarget assignments)

8

cloned

No

VV1_0484

27363948

rluD

23S rRNA pseudouridine synthase D [Vibri...

325

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1QYU

69.8%

Vibrio vulnificus

IDP90655
(show subtarget assignments)

8

expressed

No

Cj1346c

15792669

dxr

1-deoxy-D-xylulose 5-phosphate reductois...

356

Predicted Essential

Community Requests

1R0K

36.2%

Campylobacter jejuni

IDP00781
(show subtarget assignments)

1

expressed

No

SACOL0845

57284307

est

carboxylesterase

246

Conserved Gene / Pathway

Phase 2: March 2008

1R1D

57.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP01233
(show subtarget assignments)

1

purified

No

BA_5335

30259811

estA

carboxylesterase

246

Drug Target Function

Phase 2: March 2008

1R1D

79.3%

Bacillus anthracis

Cellular processes

Detoxification

IDP00724
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1822

57286255

arsR

arsenical resistance operon repressor

104

Conserved Gene / Pathway

Phase 2: March 2008

1R1T

31.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP04048
(show subtarget assignments)

1

in_crystallization_trials

No

VC1112

15641125

biotin synthase [Vibrio cholerae O1 biov...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1R30

69.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02046
(show subtarget assignments)

1

soluble

No

CBU_1007

29541589

bioB

biotin synthase [Coxiella burnetii RSA 4...

321

Conserved; Drug target functions

Phase 3: June 2008

1R30

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04719
(show subtarget assignments)

1

expressed

No

YPO1151

218928315

bioB

biotin synthase [Yersinia pestis CO92]

345

conserved gene; putative drug target function;

Phase 4: April 2009

1R30

83.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01958
(show subtarget assignments)

1

expressed

No

FTT0937c

56708034

bioB

biotin synthase [Francisella tularensis ...

313

Drug Target

Phase 3: June 2008

1R30

49.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90631
(show subtarget assignments)

8

expressed

No

YPO2526

16122745

acyl-CoA thioester hydrolase YfbB [Yersi...

272

Predicted Essential

Community Requests

1R3D

42.3%

Yersinia pestis

IDP91776
(show subtarget assignments)

8

in_crystallization_trials

No

ACM47288

222159815

vanXD

D,D-dipeptidase VanXD [Enterococcus faec...

202

drug resistance / D,D-dipeptidase

Community Requests

1R44

70.3%

Enterococcus faecium