Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02294 (show subtarget assignments)	1	cloned	No	FTT0483c	56707625		hypothetical protein FTT0483c [Francisel...	295	Drug Target	Phase 3: June 2008	2YKR	39.7%	Francisella tularensis	Unknown function	General

IDP01472 (show subtarget assignments)	1	cloned	No	VC2631	15642626		fimbrial assembly protein PilP, putative...	172	Conserved Gene / Pathway	Phase 2: March 2008	2LC4	16.3%	Vibrio cholerae	Cell envelope	Surface structures

IDP02295 (show subtarget assignments)	1	cloned	No	FTT1212c	56708274	gloA	lactoylglutathione lyase [Francisella tu...	127	Drug Target	Phase 3: June 2008	1F9Z	56.7%	Francisella tularensis	Energy metabolism	Other

IDP01940 (show subtarget assignments)	1	cloned	No	STM1626	16764970	trg	methyl-accepting chemotaxis protein III ...	541	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	35.5%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00408 (show subtarget assignments)	1	cloned	No	YPO2735	16122939	ccmB	heme exporter protein B	219	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02297 (show subtarget assignments)	1	cloned	No	FTT1235c	56708297	lpcC	glycosyl transferase group 1 family prot...	354	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2GEJ	17.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02767 (show subtarget assignments)	1	cloned	No	GBAA4750	47530050		D-alanyl-D-alanine carboxypeptidase fami...	259	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02766 (show subtarget assignments)	1	cloned	No	GBAA3318	47528603		hypothetical protein GBAA3318 [Bacillus ...	169	Drug target motif;	Phase 3: June 2008			Bacillus anthracis	N/A	N/A

IDP02304 (show subtarget assignments)	1	cloned	No	GBAA0703	47525984	qoxA	quinol oxidase, subunit II [Bacillus ant...	291	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FFT	33.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02769 (show subtarget assignments)	1	cloned	No	FTT0304c	56707457	nfnB	dihydropteridine reductase [Francisella ...	217	Drug Target	Phase 3: June 2008	3HZN	45.6%	Francisella tularensis	Energy metabolism	Electron transport

IDP00740 (show subtarget assignments)	1	cloned	No	SACOL1105	57285891	pdhD	dihydrolipoamide dehydrogenase	468	Drug Target Function	Phase 2: March 2008	1EBD	70.9%	Staphylococcus aureus	Energy metabolism	Pyruvate dehydrogenase

IDP00406 (show subtarget assignments)	1	cloned	No	YPO3410	16123559		hypothetical protein YPO3410	115	Virulence Associated Factor	Phase 2: March 2008	3UTK	26.1%	Yersinia pestis	Cell envelope	Other

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP04604 (show subtarget assignments)	1	cloned	No	BAS3678	49186677		30S ribosomal protein S2 [Bacillus anthr...	233	Proposed to be essential proteins	Phase 4: April 2009	1FJG	56.2%	Bacillus anthracis

IDP04606 (show subtarget assignments)	1	cloned	No	BAS3692	49186691		tRNA (guanine-N(1)-)-methyltransferase [...	244	Proposed to be essential proteins	Phase 4: April 2009	3KY7	62.3%	Bacillus anthracis

IDP04615 (show subtarget assignments)	1	cloned	No	BAS4297	49187293		aspartyl-tRNA synthetase [Bacillus anthr...	591	Proposed to be essential proteins	Phase 4: April 2009	1EQR	52.7%	Bacillus anthracis

IDP00738 (show subtarget assignments)	1	cloned	No	SACOL0994	57284368	oppF	oligopeptide ABC transporter, ATP-bindin...	313	Drug Target Function	Phase 2: March 2008	2YZ2	27.2%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP02288 (show subtarget assignments)	1	cloned	No	FTT0932	56708030		ROK family protein [Francisella tularens...	283	Drug Target	Phase 3: June 2008	2YHY	29.2%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02762 (show subtarget assignments)	1	cloned	No	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01936 (show subtarget assignments)	1	cloned	No	Cj0720c	15792069	flaC	flagellin subunit protein FlaC [Campylob...	249	Known Predicted virulence-flagella; Predicted virulence-Adhesion of Campylobacte...	Phase 3: June 2008	3K8V	21.7%	Campylobacter jejuni	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP00165 (show subtarget assignments)	1	cloned	No	VC0844	15640861	acfA	accessory colonization factor AcfA	215	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP02286 (show subtarget assignments)	1	cloned	No	FTT1029	56708118	dacD	D-alanyl-D-alanine carboxypeptidase (pen...	444	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IT9	31.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP02757 (show subtarget assignments)	1	cloned	No	STM2484	16765804		hypothetical protein STM2484 [Salmonella...	66	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP04588 (show subtarget assignments)	1	cloned	No	BAS0130	49183164		preprotein translocase subunit SecY [Bac...	433	Proposed to be essential proteins	Phase 4: April 2009	3DIN	43.8%	Bacillus anthracis

IDP04591 (show subtarget assignments)	1	cloned	No	BAS0138	49183172		50S ribosomal protein L17 [Bacillus anth...	120	Proposed to be essential proteins	Phase 4: April 2009	1NKW	50.8%	Bacillus anthracis

IDP04583 (show subtarget assignments)	1	cloned	No	BAS0111	49183145		50S ribosomal protein L4 [Bacillus anthr...	207	Proposed to be essential proteins	Phase 4: April 2009	1DMG	47.1%	Bacillus anthracis

IDP02763 (show subtarget assignments)	1	cloned	No	GBAA2547	47527836		acyl-CoA dehydrogenase [Bacillus anthrac...	381	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VIG	50.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP04586 (show subtarget assignments)	1	cloned	No	BAS0117	49183151		50S ribosomal protein L16 [Bacillus anth...	144	Proposed to be essential proteins	Phase 4: April 2009	1VSA	60.4%	Bacillus anthracis

IDP04593 (show subtarget assignments)	1	cloned	No	BAS0144	49183178		30S ribosomal protein S9 [Bacillus anthr...	130	Proposed to be essential proteins	Phase 4: April 2009	1VS5	55.4%	Bacillus anthracis

IDP04599 (show subtarget assignments)	1	cloned	No	BAS2268	49185277		aspartate-semialdehyde dehydrogenase [Ba...	347	Proposed to be essential proteins	Phase 4: April 2009	2GYY	55.3%	Bacillus anthracis

IDP04571 (show subtarget assignments)	1	cloned	No	BAS0002	49183041		DNA polymerase III subunit beta [Bacillu...	379	Proposed to be essential proteins	Phase 4: April 2009	2AWA	42%	Bacillus anthracis

IDP04568 (show subtarget assignments)	1	cloned	No	CPF_2087	110800786		stage III sporulation protein AA [Clostr...	294	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP04575 (show subtarget assignments)	1	cloned	No	BAS0037	49183072		methionyl-tRNA synthetase [Bacillus anth...	660	Proposed to be essential proteins	Phase 4: April 2009	4DLP	36.2%	Bacillus anthracis

IDP04565 (show subtarget assignments)	1	cloned	No	CPF_1805	110798813		putative lipoprotein [Clostridium perfri...	281	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04022 (show subtarget assignments)	1	cloned	No	BAS0095	49183129		preprotein translocase subunit SecE [Bac...	59	Proposed to be essential proteins	Phase 4: April 2009	3DIN	33.9%	Bacillus anthracis

IDP04567 (show subtarget assignments)	1	cloned	No	CPF_2099	110800052		putative lipoprotein [Clostridium perfri...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04577 (show subtarget assignments)	1	cloned	No	BAS0087	49183121		glutamyl-tRNA synthetase [Bacillus anthr...	485	Proposed to be essential proteins	Phase 4: April 2009	2O5R	44.4%	Bacillus anthracis

IDP02291 (show subtarget assignments)	1	cloned	No	FTT0167	56707337	hemA	glutamyl-tRNA reductase [Francisella tul...	416	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	26.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02281 (show subtarget assignments)	1	cloned	No	YPO1305	16121587	psaC	outer membrane usher protein PsaC precur...	837	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3RFZ	36.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02758 (show subtarget assignments)	1	cloned	No	GBAA_pXO2_0073	47566739		signal peptidase i, (pxo2-59) [Bacillus ...	183	Drug target motif;	Phase 3: June 2008	1B12	8.7%	Bacillus anthracis	N/A	N/A

IDP01932 (show subtarget assignments)	1	cloned	No	CBU_1099	29541673	lepB-1	signal peptidase I [Coxiella burnetii RS...	259	Conserved; Drug target functions	Phase 3: June 2008	1T7D	33.2%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01686 (show subtarget assignments)	1	cloned	No	Cj0804	15792142	pyrD	dihydroorotate dehydrogenase 2 [Campylob...	352	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1UUM	40.3%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02275 (show subtarget assignments)	1	cloned	No	FTT1158c	56708229		Type IV pili glycosylation protein [Fran...	198	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008			Francisella tularensis	Cell envelopeCellular processes	Surface structuresPathogenesis,Cell adhesion

IDP02813 (show subtarget assignments)	1	cloned	No	Cj0367c	15791734		RND efflux system, membrane fusion prote...	367	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	1T5E	29.2%	Campylobacter jejuni	Regulatory functions	Other

IDP04578 (show subtarget assignments)	1	cloned	No	BAS0089	49183123		cysteinyl-tRNA synthetase [Bacillus anth...	465	Proposed to be essential proteins	Phase 4: April 2009	1LI5	45.6%	Bacillus anthracis

IDP04600 (show subtarget assignments)	1	cloned	No	BAS2547	49185555		preprotein translocase subunit SecY [Bac...	434	Proposed to be essential proteins	Phase 4: April 2009	3DIN	42.2%	Bacillus anthracis

IDP04618 (show subtarget assignments)	1	cloned	No	BAS4456	49187451		phenylalanyl-tRNA synthetase subunit alp...	344	Proposed to be essential proteins	Phase 4: April 2009	2RHQ	57.6%	Bacillus anthracis

IDP04698 (show subtarget assignments)	1	cloned	No	YPCD1.46	16082734	yscT	needle complex export protein [Yersinia ...	261	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05064 (show subtarget assignments)	1	cloned	No	CD2370	126699985	nadC	nicotinate-nucleotide pyrophosphorylase ...	270	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1X1O	46.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04552 (show subtarget assignments)	1	cloned	No	CPF_2913	110799629	msrA	methionine sulfoxide reductase A [Clostr...	157	conserved gene; putative drug target function;	Phase 4: April 2009	3BQE	52.2%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP04550 (show subtarget assignments)	1	cloned	No	CPF_0460	110798921		sensor histidine kinase [Clostridium per...	743	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	9.6%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04554 (show subtarget assignments)	1	cloned	No	STM0791_1_506	16764154	hutH	histidine ammonia-lyase [Salmonella typh...	506	Salmonella essential protein	Phase 4: April 2009	1GK2	76.5%	Salmonella enterica

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP02738 (show subtarget assignments)	1	cloned	No	FTT1310c	56708367	hflB	ATP-dependent metalloprotease [Francisel...	638	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2DHR	39.3%	Francisella tularensis	N/A	N/A

IDP04548 (show subtarget assignments)	1	cloned	No	CPF_2413	110801184		ABC transporter, substrate-binding prote...	298	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2O1E	36.4%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP04555 (show subtarget assignments)	1	cloned	No	STM2272_1_878	16765599	gyrA	DNA gyrase subunit A [Salmonella typhimu...	878	Salmonella essential protein	Phase 4: April 2009	3NUH	57.7%	Salmonella enterica

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00717 (show subtarget assignments)	1	cloned	No	SACOL1421	57286072		phosphate ABC transporter, ATP-binding p...	283	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.9%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP02726 (show subtarget assignments)	1	cloned	No	GBAA4229	47529522		maltosaccharide ABC transporter, maltosa...	419	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZYK	41.5%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04544 (show subtarget assignments)	1	cloned	No	VC2713	9657310		osmolarity sensor protein EnvZ [Vibrio c...	438	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	16.7%	Vibrio cholerae	Regulatory functions	Other

IDP02251 (show subtarget assignments)	1	cloned	No	YPO1201	16121494		putative amino acid decarboxylase [Yersi...	768	Involved in virulence; Drug target functions	Phase 3: June 2008	2VYC	51.6%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00354 (show subtarget assignments)	1	cloned	No	lmo2471	16804509		hypothetical protein lmo2471	338	Drug Target Function	Phase 2: March 2008	1Z41	62.4%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Degradation

IDP02254 (show subtarget assignments)	1	cloned	No	FTT0766	56707880	deoD	purine nucleoside phosphorylase [Francis...	240	Drug Target	Phase 3: June 2008	1VHJ	43.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01926 (show subtarget assignments)	1	cloned	No	lmo0931	16802971		hypothetical protein lmo0931 [Listeria m...	331	Known virulence-Intracellular Survival; PMID:17908209	Phase 3: June 2008	1VQZ	44.7%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP00715 (show subtarget assignments)	1	cloned	No	SACOL1414	57286065		peptide ABC transporter, ATP-binding pro...	233	Conserved Gene / Pathway	Phase 2: March 2008	3QF4	30.8%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP02265 (show subtarget assignments)	1	cloned	No	YPO1303	16121585	psaA	pH 6 antigen precursor (antigen 4) (adhe...	158	Involved in virulence; Vaccine TargetDrug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP02723 (show subtarget assignments)	1	cloned	No	FTT0039	56707219	nuoI	NADH dehydrogenase subunit I [Francisell...	162	Conserved; Drug target functions	Phase 3: June 2008	2FUG	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP02732 (show subtarget assignments)	1	cloned	No	CBU_1982	29542537	ksgA	dimethyladenosine transferase [Coxiella ...	255	Conserved; Drug target functions	Phase 3: June 2008	3TQS	100%	Coxiella burnetii	Protein synthesis	tRNA and rRNA base modification

IDP02734 (show subtarget assignments)	1	cloned	No	GBAA1779	47527069		thioredoxin family protein [Bacillus ant...	184	Drug target motif; Drug target functions	Phase 3: June 2008	1ST9	27.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP01420 (show subtarget assignments)	1	cloned	No	VC1496	15641505		carboxy-terminal protease	665	Drug Target Function	Phase 2: March 2008	1FC6	16.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02264 (show subtarget assignments)	1	cloned	No	Cj1438c	15792756		putative sugar transferase [Campylobacte...	776	Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...	Phase 3: June 2008	3L7I	19.1%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00720 (show subtarget assignments)	1	cloned	No	SACOL1609	57286131	pbp3	penicillin-binding protein 3	691	Drug Target Function	Phase 2: March 2008	2WAF	32.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02255 (show subtarget assignments)	1	cloned	No	FTT1130c	56708207	cphA	cyanophycin synthetase [Francisella tula...	940	Drug Target	Phase 3: June 2008	2WTZ	13.3%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism	OtherNitrogen metabolism

IDP02258 (show subtarget assignments)	1	cloned	No	Cj0178	15791565		putative outer membrane siderophore rece...	755	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	3CSL	24.9%	Campylobacter jejuni	Cell envelope	Other

IDP04549 (show subtarget assignments)	1	cloned	No	CPF_0346	110800626		putative lioprotein [Clostridium perfrin...	184	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP02259 (show subtarget assignments)	1	cloned	No	GBAA2164	47527458		ABC transporter ATP-binding protein [Bac...	631	Conserved; Drug target functions	Phase 3: June 2008	1YQT	21.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP04551 (show subtarget assignments)	1	cloned	No	CPF_2912	110800993	maa	maltose transacetylase [Clostridium perf...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1OCX	64.6%	Clostridium perfringens	Cellular processes	Detoxification

IDP00723 (show subtarget assignments)	1	cloned	No	SACOL1668	57284681		peptidase, U32 family	307	Drug Target Function	Phase 2: March 2008			Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00005 (show subtarget assignments)	1	cloned	No	BA_0552	30254078		internalin, putative	1070	Virulence/Drug Target Homolog	Phase 1: October 2007	1M9S	13.5%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP00358 (show subtarget assignments)	1	cloned	No	lmo2229	16804268		hypothetical protein lmo2229	714	Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs	Phase 2: March 2008	3UDF	29.7%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02736 (show subtarget assignments)	1	cloned	No	GBAA4352	47778283	argD	acetylornithine aminotransferase [Bacill...	386	Conserved; Essential; Drug target functions	Phase 3: June 2008	2E54	44%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP01432 (show subtarget assignments)	1	cloned	No	VC1918	15641920		peptidyl-prolyl cis-trans isomerse D	619	Drug Target Function	Phase 2: March 2008	1M5Y	16%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP00725 (show subtarget assignments)	1	cloned	No	SACOL1919	57284837		transcriptional regulator, Fur family	148	Conserved Gene / Pathway	Phase 2: March 2008	2FE3	63.5%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP00359 (show subtarget assignments)	1	cloned	No	lmo2552	16804590	murZ	UDP-N-acetylglucosamine 1-carboxyvinyltr...	423	Drug Target Function	Phase 2: March 2008	3SG1	50.6%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01965 (show subtarget assignments)	1	cloned	No	STM1786	16765127		hydrogenase-1 small subunit [Salmonella ...	372	Conserved; Drug target functions	Phase 3: June 2008	3UQY	80.9%	Salmonella enterica	Energy metabolism	Electron transport

IDP00727 (show subtarget assignments)	1	cloned	No	SACOL2036	57284905		ABC transporter, ATP-binding protein	642	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	24.1%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP00728 (show subtarget assignments)	1	cloned	No	SACOL2210	57284991		ABC transporter, ATP-binding protein	286	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	32.2%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP02306 (show subtarget assignments)	1	cloned	No	Cj0079c	15791469	cdtA	cytolethal distending toxin [Campylobact...	268	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008	1SR4	24.3%	Campylobacter jejuni	Cellular processes	Pathogenesis

IDP00401 (show subtarget assignments)	1	cloned	No	YPO2490	161486873		putative hemolysin	2531	Virulence Associated Factor	Phase 2: March 2008	1RWR	3.9%	Yersinia pestis	Viral functions	General

IDP02750 (show subtarget assignments)	1	cloned	No	GBAA5389	47530699		transferase hexapeptide domain-containin...	170	Conserved; Essential; Drug target functions	Phase 3: June 2008	1KHR	28.8%	Bacillus anthracis	Central intermediary metabolism	Other

IDP04569 (show subtarget assignments)	1	cloned	No	CPF_2242	110799545		sensor histidine kinase [Clostridium per...	620	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	10%	Clostridium perfringens	Signal transduction	Two-component systems

IDP04556 (show subtarget assignments)	1	cloned	No	YPO3008	218930055		putative two-component sensor histidine ...	514	putative drug target function;	Phase 4: April 2009	2C2A	16%	Yersinia pestis	Regulatory functions	Other

IDP02759 (show subtarget assignments)	1	cloned	No	YPO0102	16120449		hypothetical protein YPO0102 [Yersinia p...	194	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP02282 (show subtarget assignments)	1	cloned	No	FTT0491c	56707633	gph	phosphoglycolate phosphatase [Francisell...	224	Drug Target	Phase 3: June 2008	2HSZ	32.6%	Francisella tularensis	Energy metabolism	Sugars

IDP04579 (show subtarget assignments)	1	cloned	No	BAS0098	49183132		50S ribosomal protein L1 [Bacillus anthr...	230	Proposed to be essential proteins	Phase 4: April 2009	3QOY	56.3%	Bacillus anthracis

IDP04580 (show subtarget assignments)	1	cloned	No	BAS0103	49183137		DNA-directed RNA polymerase subunit beta...	1203	Proposed to be essential proteins	Phase 4: April 2009	2GHO	53.6%	Bacillus anthracis

IDP01916 (show subtarget assignments)	1	cloned	No	lmo0327	16802372		hypothetical protein lmo0327 [Listeria m...	1348	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	3M18	3.5%	Listeria monocytogenes	Central intermediary metabolism	Other

IDP00714 (show subtarget assignments)	1	cloned	No	SACOL1198	57285941	ftsA	cell division protein FtsA	470	Drug Target Function	Phase 2: March 2008	1E4F	18.3%	Staphylococcus aureus	Cellular processes	Cell division

IDP02294
(show subtarget assignments)

1

cloned

No

FTT0483c

56707625

hypothetical protein FTT0483c [Francisel...

295

Drug Target

Phase 3: June 2008

2YKR

39.7%

Francisella tularensis

Unknown function

General

IDP01472
(show subtarget assignments)

1

cloned

No

VC2631

15642626

fimbrial assembly protein PilP, putative...

172

Conserved Gene / Pathway

Phase 2: March 2008

2LC4

16.3%

Vibrio cholerae

Cell envelope

Surface structures

IDP02295
(show subtarget assignments)

1

cloned

No

FTT1212c

56708274

gloA

lactoylglutathione lyase [Francisella tu...

127

Drug Target

Phase 3: June 2008

1F9Z

56.7%

Francisella tularensis

Energy metabolism

Other

IDP01940
(show subtarget assignments)

1

cloned

No

STM1626

16764970

trg

methyl-accepting chemotaxis protein III ...

541

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

35.5%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00408
(show subtarget assignments)

1

cloned

No

YPO2735

16122939

ccmB

heme exporter protein B

219

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02297
(show subtarget assignments)

1

cloned

No

FTT1235c

56708297

lpcC

glycosyl transferase group 1 family prot...

354

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2GEJ

17.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02767
(show subtarget assignments)

1

cloned

No

GBAA4750

47530050

D-alanyl-D-alanine carboxypeptidase fami...

259

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02766
(show subtarget assignments)

1

cloned

No

GBAA3318

47528603

hypothetical protein GBAA3318 [Bacillus ...

169

Drug target motif;

Phase 3: June 2008

Bacillus anthracis

N/A

IDP02304
(show subtarget assignments)

1

cloned

No

GBAA0703

47525984

qoxA

quinol oxidase, subunit II [Bacillus ant...

291

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FFT

33.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02769
(show subtarget assignments)

1

cloned

No

FTT0304c

56707457

nfnB

dihydropteridine reductase [Francisella ...

217

Drug Target

Phase 3: June 2008

3HZN

45.6%

Francisella tularensis

Energy metabolism

Electron transport

IDP00740
(show subtarget assignments)

1

cloned

No

SACOL1105

57285891

pdhD

dihydrolipoamide dehydrogenase

468

Drug Target Function

Phase 2: March 2008

1EBD

70.9%

Staphylococcus aureus

Energy metabolism

Pyruvate dehydrogenase

IDP00406
(show subtarget assignments)

1

cloned

No

YPO3410

16123559

hypothetical protein YPO3410

115

Virulence Associated Factor

Phase 2: March 2008

3UTK

26.1%

Yersinia pestis

Cell envelope

Other

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP04604
(show subtarget assignments)

1

cloned

No

BAS3678

49186677

30S ribosomal protein S2 [Bacillus anthr...

233

Proposed to be essential proteins

Phase 4: April 2009

1FJG

56.2%

Bacillus anthracis

IDP04606
(show subtarget assignments)

1

cloned

No

BAS3692

49186691

tRNA (guanine-N(1)-)-methyltransferase [...

244

Proposed to be essential proteins

Phase 4: April 2009

3KY7

62.3%

Bacillus anthracis

IDP04615
(show subtarget assignments)

1

cloned

No

BAS4297

49187293

aspartyl-tRNA synthetase [Bacillus anthr...

591

Proposed to be essential proteins

Phase 4: April 2009

1EQR

52.7%

Bacillus anthracis

IDP00738
(show subtarget assignments)

1

cloned

No

SACOL0994

57284368

oppF

oligopeptide ABC transporter, ATP-bindin...

313

Drug Target Function

Phase 2: March 2008

2YZ2

27.2%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP02288
(show subtarget assignments)

1

cloned

No

FTT0932

56708030

ROK family protein [Francisella tularens...

283

Drug Target

Phase 3: June 2008

2YHY

29.2%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02762
(show subtarget assignments)

1

cloned

No

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01936
(show subtarget assignments)

1

cloned

No

Cj0720c

15792069

flaC

flagellin subunit protein FlaC [Campylob...

249

Known Predicted virulence-flagella; Predicted virulence-Adhesion of Campylobacte...

Phase 3: June 2008

3K8V

21.7%

Campylobacter jejuni

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP00165
(show subtarget assignments)

1

cloned

No

VC0844

15640861

acfA

accessory colonization factor AcfA

215

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP02286
(show subtarget assignments)

1

cloned

No

FTT1029

56708118

dacD

D-alanyl-D-alanine carboxypeptidase (pen...

444

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IT9

31.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP02757
(show subtarget assignments)

1

cloned

No

STM2484

16765804

hypothetical protein STM2484 [Salmonella...

66

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP04588
(show subtarget assignments)

1

cloned

No

BAS0130

49183164

preprotein translocase subunit SecY [Bac...

433

Proposed to be essential proteins

Phase 4: April 2009

3DIN

43.8%

Bacillus anthracis

IDP04591
(show subtarget assignments)

1

cloned

No

BAS0138

49183172

50S ribosomal protein L17 [Bacillus anth...

120

Proposed to be essential proteins

Phase 4: April 2009

1NKW

50.8%

Bacillus anthracis

IDP04583
(show subtarget assignments)

1

cloned

No

BAS0111

49183145

50S ribosomal protein L4 [Bacillus anthr...

207

Proposed to be essential proteins

Phase 4: April 2009

1DMG

47.1%

Bacillus anthracis

IDP02763
(show subtarget assignments)

1

cloned

No

GBAA2547

47527836

acyl-CoA dehydrogenase [Bacillus anthrac...

381

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VIG

50.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP04586
(show subtarget assignments)

1

cloned

No

BAS0117

49183151

50S ribosomal protein L16 [Bacillus anth...

144

Proposed to be essential proteins

Phase 4: April 2009

1VSA

60.4%

Bacillus anthracis

IDP04593
(show subtarget assignments)

1

cloned

No

BAS0144

49183178

30S ribosomal protein S9 [Bacillus anthr...

130

Proposed to be essential proteins

Phase 4: April 2009

1VS5

55.4%

Bacillus anthracis

IDP04599
(show subtarget assignments)

1

cloned

No

BAS2268

49185277

aspartate-semialdehyde dehydrogenase [Ba...

347

Proposed to be essential proteins

Phase 4: April 2009

2GYY

55.3%

Bacillus anthracis

IDP04571
(show subtarget assignments)

1

cloned

No

BAS0002

49183041

DNA polymerase III subunit beta [Bacillu...

379

Proposed to be essential proteins

Phase 4: April 2009

2AWA

42%

Bacillus anthracis

IDP04568
(show subtarget assignments)

1

cloned

No

CPF_2087

110800786

stage III sporulation protein AA [Clostr...

294

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP04575
(show subtarget assignments)

1

cloned

No

BAS0037

49183072

methionyl-tRNA synthetase [Bacillus anth...

660

Proposed to be essential proteins

Phase 4: April 2009

4DLP

36.2%

Bacillus anthracis

IDP04565
(show subtarget assignments)

1

cloned

No

CPF_1805

110798813

putative lipoprotein [Clostridium perfri...

281

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04022
(show subtarget assignments)

1

cloned

No

BAS0095

49183129

preprotein translocase subunit SecE [Bac...

59

Proposed to be essential proteins

Phase 4: April 2009

3DIN

33.9%

Bacillus anthracis

IDP04567
(show subtarget assignments)

1

cloned

No

CPF_2099

110800052

putative lipoprotein [Clostridium perfri...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04577
(show subtarget assignments)

1

cloned

No

BAS0087

49183121

glutamyl-tRNA synthetase [Bacillus anthr...

485

Proposed to be essential proteins

Phase 4: April 2009

2O5R

44.4%

Bacillus anthracis

IDP02291
(show subtarget assignments)

1

cloned

No

FTT0167

56707337

hemA

glutamyl-tRNA reductase [Francisella tul...

416

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

26.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02281
(show subtarget assignments)

1

cloned

No

YPO1305

16121587

psaC

outer membrane usher protein PsaC precur...

837

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3RFZ

36.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02758
(show subtarget assignments)

1

cloned

No

GBAA_pXO2_0073

47566739

signal peptidase i, (pxo2-59) [Bacillus ...

183

Drug target motif;

Phase 3: June 2008

1B12

8.7%

Bacillus anthracis

N/A

IDP01932
(show subtarget assignments)

1

cloned

No

CBU_1099

29541673

lepB-1

signal peptidase I [Coxiella burnetii RS...

259

Conserved; Drug target functions

Phase 3: June 2008

1T7D

33.2%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01686
(show subtarget assignments)

1

cloned

No

Cj0804

15792142

pyrD

dihydroorotate dehydrogenase 2 [Campylob...

352

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1UUM

40.3%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02275
(show subtarget assignments)

1

cloned

No

FTT1158c

56708229

Type IV pili glycosylation protein [Fran...

198

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

Francisella tularensis

Cell envelopeCellular processes

Surface structuresPathogenesis,Cell adhesion

IDP02813
(show subtarget assignments)

1

cloned

No

Cj0367c

15791734

RND efflux system, membrane fusion prote...

367

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

1T5E

29.2%

Campylobacter jejuni

Regulatory functions

Other

IDP04578
(show subtarget assignments)

1

cloned

No

BAS0089

49183123

cysteinyl-tRNA synthetase [Bacillus anth...

465

Proposed to be essential proteins

Phase 4: April 2009

1LI5

45.6%

Bacillus anthracis

IDP04600
(show subtarget assignments)

1

cloned

No

BAS2547

49185555

preprotein translocase subunit SecY [Bac...

434

Proposed to be essential proteins

Phase 4: April 2009

3DIN

42.2%

Bacillus anthracis

IDP04618
(show subtarget assignments)

1

cloned

No

BAS4456

49187451

phenylalanyl-tRNA synthetase subunit alp...

344

Proposed to be essential proteins

Phase 4: April 2009

2RHQ

57.6%

Bacillus anthracis

IDP04698
(show subtarget assignments)

1

cloned

No

YPCD1.46

16082734

yscT

needle complex export protein [Yersinia ...

261

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05064
(show subtarget assignments)

1

cloned

No

CD2370

126699985

nadC

nicotinate-nucleotide pyrophosphorylase ...

270

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1X1O

46.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04552
(show subtarget assignments)

1

cloned

No

CPF_2913

110799629

msrA

methionine sulfoxide reductase A [Clostr...

157

conserved gene; putative drug target function;

Phase 4: April 2009

3BQE

52.2%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP04550
(show subtarget assignments)

1

cloned

No

CPF_0460

110798921

sensor histidine kinase [Clostridium per...

743

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

9.6%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04554
(show subtarget assignments)

1

cloned

No

STM0791_1_506

16764154

hutH

histidine ammonia-lyase [Salmonella typh...

506

Salmonella essential protein

Phase 4: April 2009

1GK2

76.5%

Salmonella enterica

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP02738
(show subtarget assignments)

1

cloned

No

FTT1310c

56708367

hflB

ATP-dependent metalloprotease [Francisel...

638

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2DHR

39.3%

Francisella tularensis

N/A

IDP04548
(show subtarget assignments)

1

cloned

No

CPF_2413

110801184

ABC transporter, substrate-binding prote...

298

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2O1E

36.4%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP04555
(show subtarget assignments)

1

cloned

No

STM2272_1_878

16765599

gyrA

DNA gyrase subunit A [Salmonella typhimu...

878

Salmonella essential protein

Phase 4: April 2009

3NUH

57.7%

Salmonella enterica

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00717
(show subtarget assignments)

1

cloned

No

SACOL1421

57286072

phosphate ABC transporter, ATP-binding p...

283

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.9%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP02726
(show subtarget assignments)

1

cloned

No

GBAA4229

47529522

maltosaccharide ABC transporter, maltosa...

419

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZYK

41.5%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04544
(show subtarget assignments)

1

cloned

No

VC2713

9657310

osmolarity sensor protein EnvZ [Vibrio c...

438

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

16.7%

Vibrio cholerae

Regulatory functions

Other

IDP02251
(show subtarget assignments)

1

cloned

No

YPO1201

16121494

putative amino acid decarboxylase [Yersi...

768

Involved in virulence; Drug target functions

Phase 3: June 2008

2VYC

51.6%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00354
(show subtarget assignments)

1

cloned

No

lmo2471

16804509

hypothetical protein lmo2471

338

Drug Target Function

Phase 2: March 2008

1Z41

62.4%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Degradation

IDP02254
(show subtarget assignments)

1

cloned

No

FTT0766

56707880

deoD

purine nucleoside phosphorylase [Francis...

240

Drug Target

Phase 3: June 2008

1VHJ

43.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01926
(show subtarget assignments)

1

cloned

No

lmo0931

16802971

hypothetical protein lmo0931 [Listeria m...

331

Known virulence-Intracellular Survival; PMID:17908209

Phase 3: June 2008

1VQZ

44.7%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP00715
(show subtarget assignments)

1

cloned

No

SACOL1414

57286065

peptide ABC transporter, ATP-binding pro...

233

Conserved Gene / Pathway

Phase 2: March 2008

3QF4

30.8%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP02265
(show subtarget assignments)

1

cloned

No

YPO1303

16121585

psaA

pH 6 antigen precursor (antigen 4) (adhe...

158

Involved in virulence; Vaccine TargetDrug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP02723
(show subtarget assignments)

1

cloned

No

FTT0039

56707219

nuoI

NADH dehydrogenase subunit I [Francisell...

162

Conserved; Drug target functions

Phase 3: June 2008

2FUG

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP02732
(show subtarget assignments)

1

cloned

No

CBU_1982

29542537

ksgA

dimethyladenosine transferase [Coxiella ...

255

Conserved; Drug target functions

Phase 3: June 2008

3TQS

100%

Coxiella burnetii

Protein synthesis

tRNA and rRNA base modification

IDP02734
(show subtarget assignments)

1

cloned

No

GBAA1779

47527069

thioredoxin family protein [Bacillus ant...

184

Drug target motif; Drug target functions

Phase 3: June 2008

1ST9

27.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP01420
(show subtarget assignments)

1

cloned

No

VC1496

15641505

carboxy-terminal protease

665

Drug Target Function

Phase 2: March 2008

1FC6

16.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02264
(show subtarget assignments)

1

cloned

No

Cj1438c

15792756

putative sugar transferase [Campylobacte...

776

Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...

Phase 3: June 2008

3L7I

19.1%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00720
(show subtarget assignments)

1

cloned

No

SACOL1609

57286131

pbp3

penicillin-binding protein 3

691

Drug Target Function

Phase 2: March 2008

2WAF

32.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02255
(show subtarget assignments)

1

cloned

No

FTT1130c

56708207

cphA

cyanophycin synthetase [Francisella tula...

940

Drug Target

Phase 3: June 2008

2WTZ

13.3%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism

OtherNitrogen metabolism

IDP02258
(show subtarget assignments)

1

cloned

No

Cj0178

15791565

putative outer membrane siderophore rece...

755

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

3CSL

24.9%

Campylobacter jejuni

Cell envelope

Other

IDP04549
(show subtarget assignments)

1

cloned

No

CPF_0346

110800626

putative lioprotein [Clostridium perfrin...

184

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP02259
(show subtarget assignments)

1

cloned

No

GBAA2164

47527458

ABC transporter ATP-binding protein [Bac...

631

Conserved; Drug target functions

Phase 3: June 2008

1YQT

21.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP04551
(show subtarget assignments)

1

cloned

No

CPF_2912

110800993

maa

maltose transacetylase [Clostridium perf...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1OCX

64.6%

Clostridium perfringens

Cellular processes

Detoxification

IDP00723
(show subtarget assignments)

1

cloned

No

SACOL1668

57284681

peptidase, U32 family

307

Drug Target Function

Phase 2: March 2008

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00005
(show subtarget assignments)

1

cloned

No

BA_0552

30254078

internalin, putative

1070

Virulence/Drug Target Homolog

Phase 1: October 2007

1M9S

13.5%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP00358
(show subtarget assignments)

1

cloned

No

lmo2229

16804268

hypothetical protein lmo2229

714

Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs

Phase 2: March 2008

3UDF

29.7%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02736
(show subtarget assignments)

1

cloned

No

GBAA4352

47778283

argD

acetylornithine aminotransferase [Bacill...

386

Conserved; Essential; Drug target functions

Phase 3: June 2008

2E54

44%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP01432
(show subtarget assignments)

1

cloned

No

VC1918

15641920

peptidyl-prolyl cis-trans isomerse D

619

Drug Target Function

Phase 2: March 2008

1M5Y

16%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP00725
(show subtarget assignments)

1

cloned

No

SACOL1919

57284837

transcriptional regulator, Fur family

148

Conserved Gene / Pathway

Phase 2: March 2008

2FE3

63.5%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP00359
(show subtarget assignments)

1

cloned

No

lmo2552

16804590

murZ

UDP-N-acetylglucosamine 1-carboxyvinyltr...

423

Drug Target Function

Phase 2: March 2008

3SG1

50.6%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01965
(show subtarget assignments)

1

cloned

No

STM1786

16765127

hydrogenase-1 small subunit [Salmonella ...

372

Conserved; Drug target functions

Phase 3: June 2008

3UQY

80.9%

Salmonella enterica

Energy metabolism

Electron transport

IDP00727
(show subtarget assignments)

1

cloned

No

SACOL2036

57284905

ABC transporter, ATP-binding protein

642

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

24.1%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP00728
(show subtarget assignments)

1

cloned

No

SACOL2210

57284991

ABC transporter, ATP-binding protein

286

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

32.2%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP02306
(show subtarget assignments)

1

cloned

No

Cj0079c

15791469

cdtA

cytolethal distending toxin [Campylobact...

268

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

1SR4

24.3%

Campylobacter jejuni

Cellular processes

Pathogenesis

IDP00401
(show subtarget assignments)

1

cloned

No

YPO2490

161486873

putative hemolysin

2531

Virulence Associated Factor

Phase 2: March 2008

1RWR

3.9%

Yersinia pestis

Viral functions

General

IDP02750
(show subtarget assignments)

1

cloned

No

GBAA5389

47530699

transferase hexapeptide domain-containin...

170

Conserved; Essential; Drug target functions

Phase 3: June 2008

1KHR

28.8%

Bacillus anthracis

Central intermediary metabolism

Other

IDP04569
(show subtarget assignments)

1

cloned

No

CPF_2242

110799545

sensor histidine kinase [Clostridium per...

620

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

10%

Clostridium perfringens

Signal transduction

Two-component systems

IDP04556
(show subtarget assignments)

1

cloned

No

YPO3008

218930055

putative two-component sensor histidine ...

514

putative drug target function;

Phase 4: April 2009

2C2A

16%

Yersinia pestis

Regulatory functions

Other

IDP02759
(show subtarget assignments)

1

cloned

No

YPO0102

16120449

hypothetical protein YPO0102 [Yersinia p...

194

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP02282
(show subtarget assignments)

1

cloned

No

FTT0491c

56707633

gph

phosphoglycolate phosphatase [Francisell...

224

Drug Target

Phase 3: June 2008

2HSZ

32.6%

Francisella tularensis

Energy metabolism

Sugars

IDP04579
(show subtarget assignments)

1

cloned

No

BAS0098

49183132

50S ribosomal protein L1 [Bacillus anthr...

230

Proposed to be essential proteins

Phase 4: April 2009

3QOY

56.3%

Bacillus anthracis

IDP04580
(show subtarget assignments)

1

cloned

No

BAS0103

49183137

DNA-directed RNA polymerase subunit beta...

1203

Proposed to be essential proteins

Phase 4: April 2009

2GHO

53.6%

Bacillus anthracis

IDP01916
(show subtarget assignments)

1

cloned

No

lmo0327

16802372

hypothetical protein lmo0327 [Listeria m...

1348

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

3M18

3.5%

Listeria monocytogenes

Central intermediary metabolism

Other

IDP00714
(show subtarget assignments)

1

cloned

No

SACOL1198

57285941

ftsA

cell division protein FtsA

470

Drug Target Function

Phase 2: March 2008

1E4F

18.3%

Staphylococcus aureus

Cellular processes

Cell division