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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 13 of 60, showing 100 records out of 5973 total, starting on record 1201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP01213
(
show subtarget assignments
)
1
expressed
No
BA_3251
30257808
3-oxoacyl-(acyl-carrier-protein) synthas...
329
Drug Target Function
Phase 2: March 2008
2EBD
34.7%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00312
(
show subtarget assignments
)
1
expressed
No
CBU_0497
29653839
fabF
3-oxoacyl-acyl carrier protein synthase ...
414
Drug Target Function
Phase 2: March 2008
1B3N
60.1%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01201
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_1826
34098434
3-oxoacyl-[acyl-carrier-protein] synthas...
327
Drug Target Function
Phase 2: March 2008
1UB7
40.7%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00311
(
show subtarget assignments
)
1
soluble
No
CBU_0494
29653836
fabD
malonyl CoA-acyl carrier protein transac...
313
Drug Target Function
Phase 2: March 2008
3TQE
100%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00310
(
show subtarget assignments
)
1
expressed
No
CBU_0493
29653835
fabH
3-oxoacyl-(acyl-carrier-protein) synthas...
319
Drug Target Function
Phase 2: March 2008
1HN9
54.4%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01193
(
show subtarget assignments
)
1
purified
No
BA_1185
30254899
fabF
3-oxoacyl-(acyl-carrier-protein) synthas...
412
Drug Target Function
Phase 2: March 2008
3O04
67.7%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01192
(
show subtarget assignments
)
1
purified
No
BA_1184
34098435
3-oxoacyl-[acyl-carrier-protein] synthas...
310
Drug Target Function
Phase 2: March 2008
1ZOW
61%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01182
(
show subtarget assignments
)
1
in_pdb
3HYK
Yes
BA_0250
61211622
Holo-[acyl-carrier-protein] synthase (Ho...
119
Drug Target Function
Phase 2: March 2008
3HYK
100%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00304
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0038
29653401
3-oxoacyl-(acyl-carrier-protein) synthas...
327
Drug Target Function
Phase 2: March 2008
1UB7
29.6%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00303
(
show subtarget assignments
)
1
in_crystallization_trials
No
CBU_0035
29653398
beta-ketoacyl synthase
424
Drug Target Function
Phase 2: March 2008
3E60
36.8%
Coxiella burnetii
Fatty acid and phospholipid metabolism
Biosynthesis
IDP02057
(
show subtarget assignments
)
1
soluble
No
Cj1311
15792634
neuA2
acylneuraminate cytidylyltransferase [Ca...
232
Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...
Phase 3: June 2008
1QWJ
26.3%
Campylobacter jejuni
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00589
(
show subtarget assignments
)
1
soluble
No
YPO0954
161486886
mltC
membrane-bound lytic murein transglycosy...
358
Drug Target Function
Phase 2: March 2008
2Y8P
19.3%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01124
(
show subtarget assignments
)
1
purified
No
BA_4938
33301353
UDP-N-acetylmuramate--L-alanine ligase (...
436
Conserved Gene / Pathway
Phase 2: March 2008
1J6U
30.4%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01733
(
show subtarget assignments
)
1
cloned
No
FTT0811c
56707922
murG
UDP-N-acetylglucosamine--N-acetylmuramyl...
371
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
1F0K
39.4%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00583
(
show subtarget assignments
)
1
expressed
No
YPO2752
16122956
mepA
penicillin-insensitive murein endopeptid...
275
Drug Target Function
Phase 2: March 2008
1TZP
67.6%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01488
(
show subtarget assignments
)
1
in_crystallization_trials
No
VCA0572
15601331
ddl
D-alanyl-alanine synthetase A
334
Conserved Gene / Pathway
Phase 2: March 2008
2FB9
34.1%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01103
(
show subtarget assignments
)
1
cloned
No
BA_1387
47605671
D-alanine--poly(phosphoribitol) ligase s...
79
Drug Target Function
Phase 2: March 2008
1DV5
45.6%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00575
(
show subtarget assignments
)
1
in_pdb
3V4Z
No
YPO0557
16120885
ddl
D-alanine--D-alanine ligase
306
Drug Target Function
Phase 2: March 2008
3V4Z
100%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01726
(
show subtarget assignments
)
1
cloned
No
GBAA5252
47530558
D-alanyl-D-alanine carboxypeptidase fami...
279
Drug target motif; Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1XP4
29.4%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01078
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM4137
16767396
murB
UDP-N-acetylenolpyruvoylglucosamine redu...
342
Essential Gene
Phase 2: March 2008
1MBB
82.2%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02373
(
show subtarget assignments
)
1
expressed
No
FTT0438
56707582
mpl
UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...
456
Conserved; Drug target functions
Phase 3: June 2008
3HN7
41.6%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00015
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_4048
47605856
UDP-N-acetylenolpyruvoylglucosamine redu...
301
Drug Target Homolog
Phase 1: October 2007
1HSK
39.5%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00548
(
show subtarget assignments
)
1
cloned
No
YPO0549
16120877
ftsI
penicillin-binding protein 3
587
Drug Target Function
Phase 2: March 2008
3OC2
41.4%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01513
(
show subtarget assignments
)
1
purified
No
VC1312
161582006
alr
alanine racemase
407
Conserved Gene / Pathway
Phase 2: March 2008
4ECL
26%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02327
(
show subtarget assignments
)
1
expressed
No
YPO1320
16121602
dacC
D-alanyl-D-alanine carboxypeptidase [Yer...
432
Drug target motif; Conserved; CD; Drug target functions
Phase 3: June 2008
3IT9
60.6%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01019
(
show subtarget assignments
)
0
work_stopped
No
STM0228
16763618
lpxA
UDP-N-acetylglucosamine acyltransferase ...
262
Essential Gene
Phase 2: March 2008
1LXA
93.5%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00535
(
show subtarget assignments
)
1
purified
No
YPO3506
16123652
dacB
D-alanyl-D-alanine carboxypeptidase/endo...
482
Drug Target Function
Phase 2: March 2008
2EX2
77.2%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00229
(
show subtarget assignments
)
1
soluble
No
YPO0417
16120750
-
putative O-antigen biosynthesis protein
410
Virulence
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01007
(
show subtarget assignments
)
1
cloned
No
STM2531
16765851
pbpC
penicillin-binding protein 1C
771
Drug Target Function
Phase 2: March 2008
2OLU
21.5%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02469
(
show subtarget assignments
)
1
cloned
No
FTT0573
56707702
alr
alanine racemase [Francisella tularensis...
365
Conserved; Drug target functions
Phase 3: June 2008
4A3Q
31.7%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00007
(
show subtarget assignments
)
0
work_stopped
No
BA_0847
30254435
racE-1
glutamate racemase
276
Drug Target Homolog
Phase 1: October 2007
2DWU
100%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00226
(
show subtarget assignments
)
1
soluble
No
YPO3938
16124066
glgP
glycogen phosphorylase
815
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 1: October 2007
1EM6
49.9%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02309
(
show subtarget assignments
)
1
in_crystallization_trials
No
FTT0239
56707396
murC
UDP-N-acetylmuramate--alanine ligase [Fr...
451
Conserved; Drug target functions
Phase 3: June 2008
2F00
36.1%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02399
(
show subtarget assignments
)
1
cloned
No
GBAA2559
47527848
D-alanyl-D-alanine carboxypeptidase fami...
338
Drug target motif; Drug target functions
Phase 3: June 2008
1XP4
26.3%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00523
(
show subtarget assignments
)
1
in_pdb
3OZH
3RJU
Yes
YPO1224
16121513
ampH
beta-lactamase/D-alanine carboxypeptidas...
388
Conserved Gene / Pathway
Phase 2: March 2008
3OZH
89.7%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01777
(
show subtarget assignments
)
1
cloned
No
CBU_0313
29540926
transglycosylase, Slt family [Coxiella b...
487
Conserved; Drug target functions
Phase 3: June 2008
1QSA
9.9%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00982
(
show subtarget assignments
)
1
soluble
No
STM2062
16765392
dacD
D-alanyl-D-alanine carboxypeptidase
390
Drug Target Function
Phase 2: March 2008
1NZO
45.1%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00221
(
show subtarget assignments
)
1
soluble
No
YPO0164
16120507
-
putative membrane receptor protein
686
Virulence
Phase 1: October 2007
2HDF
20.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00219
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1938
16122184
-
probable deoR-family transcriptional reg...
256
Virulence
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01836
(
show subtarget assignments
)
1
cloned
No
Cj1659
15792963
p19
hypothetical protein Cj1659 [Campylobact...
179
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
3LZL
88.3%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02286
(
show subtarget assignments
)
1
cloned
No
FTT1029
56708118
dacD
D-alanyl-D-alanine carboxypeptidase (pen...
444
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3IT9
31.1%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02617
(
show subtarget assignments
)
1
expressed
No
GBAA1286
47526551
D-alanyl-D-alanine carboxypeptidase fami...
428
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3MFD
24.5%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00213
(
show subtarget assignments
)
1
soluble
No
YPO0628
16120954
-
putative translational inhibitor protein...
134
Virulence
Phase 1: October 2007
3I7T
35.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02791
(
show subtarget assignments
)
1
cloned
No
lmo1892
16803931
pbpA
hypothetical protein lmo1892 [Listeria m...
827
Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...
Phase 3: June 2008
2OLU
30.8%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00919
(
show subtarget assignments
)
1
in_pdb
3Q1K
3I12
No
STM0380
16763760
ddl
D-alanyl-alanine synthetase A
364
Conserved Gene / Pathway
Phase 2: March 2008
3I12
100%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01935
(
show subtarget assignments
)
1
expressed
No
CBU_0136
29540756
murC
UDP-N-acetylmuramate--alanine ligase [Co...
465
Conserved; Drug target functions
Phase 3: June 2008
2F00
47.7%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00910
(
show subtarget assignments
)
1
cloned
No
STM0190
16763580
mrcB
penicillin-binding protein 1b
840
Drug Target Function
Phase 2: March 2008
3FWL
84%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00906
(
show subtarget assignments
)
0
work_stopped
No
STM0129
16763519
murC
UDP-N-acetylmuramate--L-alanine ligase
491
Essential Gene
Phase 2: March 2008
2F00
94.5%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00905
(
show subtarget assignments
)
0
work_stopped
No
STM0126
16763516
murD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...
438
Essential Gene
Phase 2: March 2008
1E0D
92.2%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00904
(
show subtarget assignments
)
0
work_stopped
No
STM0124
16763514
murF
UDP-N-acetylmuramoyl-tripeptide--D-alany...
452
Conserved Gene / Pathway
Phase 2: March 2008
1GG4
87.6%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00903
(
show subtarget assignments
)
0
work_stopped
No
STM0123
16763513
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--...
495
Essential Gene
Phase 2: March 2008
1E8C
91.3%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00900
(
show subtarget assignments
)
0
work_stopped
No
STM4247
16767497
alr
alanine racemase
359
Conserved Gene / Pathway
Phase 2: March 2008
2RJG
91.4%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00899
(
show subtarget assignments
)
1
soluble
No
STM3294
16766590
glmM
phosphoglucosamine mutase
445
Essential Gene
Phase 2: March 2008
3PDK
46.7%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00202
(
show subtarget assignments
)
1
soluble
No
YPO2731
16122935
-
putative membrane protein
679
Virulence
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02223
(
show subtarget assignments
)
1
expressed
No
YPO0550
16120878
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--...
490
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1E8C
76.7%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01487
(
show subtarget assignments
)
1
soluble
No
VCA0270
15601038
D-alanyl-D-alanine carboxypeptidase
389
Drug Target Function
Phase 2: March 2008
1NZO
44.5%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02225
(
show subtarget assignments
)
1
cloned
No
CBU_1338
29541903
D-alanine--D-alanine ligase [Coxiella bu...
372
Conserved; Drug target functions
Phase 3: June 2008
3TQT
100%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00462
(
show subtarget assignments
)
1
soluble
No
YPO1025
16121325
mltA
murein transglycosylase A
390
Drug Target Function
Phase 2: March 2008
2GAE
62.8%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00860
(
show subtarget assignments
)
1
cloned
No
STM1910
16765252
putative penicillin-binding protein
623
Drug Target Function
Phase 2: March 2008
3PBN
25.5%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01682
(
show subtarget assignments
)
1
cloned
No
GBAA5104
47530405
D-alanyl-D-alanine carboxypeptidase fami...
286
Drug target motif; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02207
(
show subtarget assignments
)
1
expressed
No
YPO0612
16120938
putative sugar binding protein [Yersinia...
414
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3QUF
24.6%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02037
(
show subtarget assignments
)
1
cloned
No
CBU_0135
29540755
murG
UDP-N-acetylglucosamine--N-acetylmuramyl...
358
Conserved; Drug target functions
Phase 3: June 2008
1F0K
46.6%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02767
(
show subtarget assignments
)
1
cloned
No
GBAA4750
47530050
D-alanyl-D-alanine carboxypeptidase fami...
259
Drug target motif; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP04441
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0321
115346137
alr
alanine racemase (biosynthetic) [Yersini...
359
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2RJG
71.9%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01676
(
show subtarget assignments
)
1
cloned
No
CBU_0869
29541462
alr
alanine racemase [Coxiella burnetii RSA ...
364
Conserved; Drug target functions
Phase 3: June 2008
2RJG
42.9%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00822
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL2253
57285032
femX
femX protein
421
Conserved Gene / Pathway
Phase 2: March 2008
1LRZ
26.7%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02200
(
show subtarget assignments
)
1
cloned
No
CBU_1103
29541677
transglycosylase, Slt family [Coxiella b...
425
Conserved; Drug target functions
Phase 3: June 2008
1QSA
16.2%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02576
(
show subtarget assignments
)
1
purified
No
GBAA0246
47525503
murF
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...
458
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2AM1
37.1%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00022
(
show subtarget assignments
)
1
cloned
No
BA_5578
81714842
UDP-N-acetylglucosamine 1-carboxyvinyltr...
429
Drug Target Homolog
Phase 1: October 2007
3SG1
49.7%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00802
(
show subtarget assignments
)
1
cloned
No
SACOL1704
57284716
mreC
rod shape-determining protein MreC
280
Conserved Gene / Pathway
Phase 2: March 2008
2J5U
29.6%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00178
(
show subtarget assignments
)
1
soluble
No
YPO3405
16123554
-
putative ABC transporter, integral membr...
256
Similar to Essential SALTY
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00177
(
show subtarget assignments
)
1
purified
No
YPO3007
16123186
-
putative membrane protein
509
Virulence
Phase 1: October 2007
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00794
(
show subtarget assignments
)
1
cloned
No
SACOL1194
57284479
pbp1
penicillin-binding protein 1
744
Drug Target Function
Phase 2: March 2008
1PYY
30.9%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00425
(
show subtarget assignments
)
1
purified
No
YPO3863
16123998
wecC
UDP-N-acetyl-D-mannosamine dehydrogenase...
420
Conserved Gene / Pathway
Phase 2: March 2008
3OJL
42.4%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00780
(
show subtarget assignments
)
1
expressed
No
SACOL0694
57285664
tagH protein, teichoic acid ABC transpor...
264
Conserved Gene / Pathway
Phase 2: March 2008
1VPL
23.9%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00417
(
show subtarget assignments
)
1
cloned
No
YPO2604
16122817
pbpA
penicillin-binding protein 2
631
Drug Target Function
Phase 2: March 2008
3OC2
26.1%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00021
(
show subtarget assignments
)
1
in_pdb
3SG1
No
BA_5529
81714862
UDP-N-acetylglucosamine 1-carboxyvinyltr...
434
Drug Target Homolog
Phase 1: October 2007
3SG1
100%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00413
(
show subtarget assignments
)
1
soluble
No
YPCD1.60
16082748
yscK
type III secretion apparatus component
209
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02024
(
show subtarget assignments
)
1
expressed
No
CBU_0131
29540751
murD
UDP-N-acetylmuramoylalanine--D-glutamate...
442
Conserved; Drug target functions
Phase 3: June 2008
1E0D
43%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02026
(
show subtarget assignments
)
1
crystallized
No
CBU_0123
29540743
murE
UDP-N-acetylmuramoylalanyl-D-glutamate-2...
489
Conserved; Drug target functions
Phase 3: June 2008
1E8C
41.3%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02740
(
show subtarget assignments
)
1
expressed
No
GBAA1950
47527245
D-alanyl-D-alanine carboxypeptidase fami...
285
Drug target motif; Drug target functions
Phase 3: June 2008
3HUM
28.7%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02731
(
show subtarget assignments
)
1
expressed
No
CBU_0124
29540744
murF
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...
446
Conserved; Drug target functions
Phase 3: June 2008
1GG4
43.9%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01929
(
show subtarget assignments
)
1
cloned
No
lmo1076
16803116
hypothetical protein lmo1076 [Listeria m...
572
Known virulence-Invasion; Possible Vaccine Candidate; PMID:15009888
Phase 3: June 2008
3FI7
31.5%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01477
(
show subtarget assignments
)
1
purified
No
VC2762
15642755
glmU
bifunctional N-acetylglucosamine-1-phosp...
453
Drug Target Function
Phase 2: March 2008
1HV9
67.5%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01435
(
show subtarget assignments
)
1
purified
No
VC1956
15641958
lytic murein transglycosylase, putative ...
323
Drug Target Function
Phase 2: March 2008
4ANR
32.5%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00359
(
show subtarget assignments
)
1
cloned
No
lmo2552
16804590
murZ
UDP-N-acetylglucosamine 1-carboxyvinyltr...
423
Drug Target Function
Phase 2: March 2008
3SG1
50.6%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00020
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_5315
47605857
UDP-N-acetylenolpyruvoylglucosamine redu...
305
Drug Target Homolog
Phase 1: October 2007
1HSK
59.7%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00358
(
show subtarget assignments
)
1
cloned
No
lmo2229
16804268
hypothetical protein lmo2229
714
Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs
Phase 2: March 2008
3UDF
29.7%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02154
(
show subtarget assignments
)
1
expressed
No
GBAA2526
47527815
D-alanyl-D-alanine carboxypeptidase fami...
243
Drug target motif; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01463
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC2514
15642510
UDP-N-acetylglucosamine 1-carboxyvinyltr...
419
Drug Target Function
Phase 2: March 2008
3VCY
85.9%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01466
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC2542
15642537
UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...
451
Conserved Gene / Pathway
Phase 2: March 2008
3HN7
51%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00720
(
show subtarget assignments
)
1
cloned
No
SACOL1609
57286131
pbp3
penicillin-binding protein 3
691
Drug Target Function
Phase 2: March 2008
2WAF
32.6%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00718
(
show subtarget assignments
)
1
soluble
No
SACOL1434
57286085
alanine racemase family protein
361
Conserved Gene / Pathway
Phase 2: March 2008
2RJG
27.1%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00355
(
show subtarget assignments
)
1
in_pdb
3R38
Yes
lmo2526
16804564
murA
UDP-N-acetylglucosamine 1-carboxyvinyltr...
430
Drug Target Function
Phase 2: March 2008
3R38
100%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01407
(
show subtarget assignments
)
1
cloned
No
VC0947
15640963
D-alanyl-D-alanine carboxypeptidase
391
Drug Target Function
Phase 2: March 2008
1NZO
52.2%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01394
(
show subtarget assignments
)
1
soluble
No
VC0700
15640719
soluble lytic murein transglycosylase
648
Drug Target Function
Phase 2: March 2008
1QSA
33.8%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00347
(
show subtarget assignments
)
1
in_pdb
3HFR
3ISV
3IST
Yes
lmo1237
16803277
racE
hypothetical protein lmo1237
266
Drug Target Function
Phase 2: March 2008
3HFR
100%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01885
(
show subtarget assignments
)
1
cloned
No
GBAA5639
47530965
D-alanyl-D-alanine carboxypeptidase, put...
423
Drug target motif; Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1XP4
32.2%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00345
(
show subtarget assignments
)
1
cloned
No
lmo0441
16802485
hypothetical protein lmo0441
678
Drug Target Function
Phase 2: March 2008
1MWR
35.3%
Listeria monocytogenes
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01375
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC0372
15640399
alr
alanine racemase
375
Conserved Gene / Pathway
Phase 2: March 2008
2RJG
57.3%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
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