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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 13 of 60, showing 100 records out of 5973 total, starting on record 1201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP05330
(
show subtarget assignments
)
1
soluble
No
BA_2605
30257222
putative lipoprotein [Bacillus anthracis...
222
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05673
(
show subtarget assignments
)
1
soluble
No
lmo0810
16802852
-
hypothetical protein lmo0810 [Listeria m...
357
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4EQB
54.6%
Listeria monocytogenes
Transport and binding proteins: Amino acids, peptides and amines
IDP04555
(
show subtarget assignments
)
1
cloned
No
STM2272_1_878
16765599
gyrA
DNA gyrase subunit A [Salmonella typhimu...
878
Salmonella essential protein
Phase 4: April 2009
3NUH
57.7%
Salmonella enterica
IDP04035
(
show subtarget assignments
)
1
in_pdb
3P0R
Yes
BAS5262
49188247
azoreductase [Bacillus anthracis str. St...
208
Proposed to be essential proteins
Phase 4: April 2009
3P0R
100%
Bacillus anthracis
IDP05128
(
show subtarget assignments
)
1
soluble
No
BA_5530
30259989
conserved hypothetical protein [Bacillus...
236
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2FPN
29.2%
Bacillus anthracis
Hypothetical proteins: Conserved
IDP05572
(
show subtarget assignments
)
1
cloned
No
BAS4090
49187088
-
stage III sporulation protein AH [Bacill...
223
essential/virulence/pathogenesis /
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3TUF
32.7%
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP04034
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0128
49183162
50S ribosomal protein L30 [Bacillus anth...
60
Proposed to be essential proteins
Phase 4: April 2009
1VS6
53.3%
Bacillus anthracis
IDP04135
(
show subtarget assignments
)
1
cloned
No
BAS4470
49187465
50S ribosomal protein L35 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1VS6
48.5%
Bacillus anthracis
IDP05285
(
show subtarget assignments
)
1
selected
No
CD0663
126698240
tcdA
toxin A [Clostridium difficile 630]
2710
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3SRZ
20%
Clostridium difficile
Cellular processes: Pathogenesis
IDP04216
(
show subtarget assignments
)
1
cloned
No
STM1894_1_336
16765236
ruvB
Holliday junction DNA helicase B [Salmon...
336
Salmonella essential protein
Phase 4: April 2009
1HQC
53%
Salmonella enterica
IDP05129
(
show subtarget assignments
)
1
cloned
No
CD0091
126697661
adk
adenylate kinase [Clostridium difficile ...
221
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3FB4
57.9%
Clostridium difficile
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
IDP04030
(
show subtarget assignments
)
1
cloned
No
YPO2532
115348229
hypothetical protein [Yersinia pestis CO...
70
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04027
(
show subtarget assignments
)
1
cloned
No
BAS4637
49187628
leucyl-tRNA synthetase [Bacillus anthrac...
802
Proposed to be essential proteins
Phase 4: April 2009
1H3N
45.9%
Bacillus anthracis
IDP04028
(
show subtarget assignments
)
1
purified
No
BAS0109
49183143
30S ribosomal protein S10 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1P6G
61.8%
Bacillus anthracis
IDP05450
(
show subtarget assignments
)
1
cloned
No
lmo2776
16804813
-
hypothetical protein lmo2776 [Listeria m...
131
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP05133
(
show subtarget assignments
)
1
cloned
No
CD0264
126697836
flhF
flagellar biosynthesis regulator FlhF [C...
338
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2J37
26%
Clostridium difficile
Protein fate: Protein and peptide secretion and trafficking
IDP04223
(
show subtarget assignments
)
8
selected
No
CAC05808
12329077
ipgD
IpgD, secreted by the Mxi-Spa machinery,...
538
Shigella effector protein
Community Requests
Shigella flexneri
IDP04038
(
show subtarget assignments
)
1
expressed
No
YPCD1.65
5832485
YPCD1.65
putative transposase [Yersinia pestis CO...
102
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04045
(
show subtarget assignments
)
1
soluble
No
FTT1747
56708745
outer membrane protein [Francisella tula...
191
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Francisella tularensis
IDP05295
(
show subtarget assignments
)
1
cloned
No
CD1816
126699424
cmk
cytidylate kinase [Clostridium difficile...
216
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1Q3T
44.4%
Clostridium difficile
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
IDP04576
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0076
49183111
lysyl-tRNA synthetase [Bacillus anthraci...
499
Proposed to be essential proteins
Phase 4: April 2009
3A74
77.6%
Bacillus anthracis
IDP05223
(
show subtarget assignments
)
1
soluble
No
lmo0160
16802208
-
peptidoglycan binding protein [Listeria ...
565
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2Y1V
19.5%
Listeria monocytogenes
Regulatory functions: Other
IDP05142
(
show subtarget assignments
)
1
cloned
No
BAS2027
49185038
-
isoleucyl-tRNA synthetase [Bacillus anth...
1033
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1ILE
38.4%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP05132
(
show subtarget assignments
)
1
cloned
No
CD0262
126697834
flhB
bifunctional flagellar biosynthesis prot...
604
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2JLH
7.9%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04572
(
show subtarget assignments
)
1
soluble
No
BAS0005
49183044
DNA gyrase subunit B [Bacillus anthracis...
640
Proposed to be essential proteins
Phase 4: April 2009
1EI1
34.4%
Bacillus anthracis
IDP04571
(
show subtarget assignments
)
1
cloned
No
BAS0002
49183041
DNA polymerase III subunit beta [Bacillu...
379
Proposed to be essential proteins
Phase 4: April 2009
2AWA
42%
Bacillus anthracis
IDP04575
(
show subtarget assignments
)
1
cloned
No
BAS0037
49183072
methionyl-tRNA synthetase [Bacillus anth...
660
Proposed to be essential proteins
Phase 4: April 2009
4DLP
36.2%
Bacillus anthracis
IDP04574
(
show subtarget assignments
)
1
soluble
No
BAS0015
49183051
seryl-tRNA synthetase [Bacillus anthraci...
424
Proposed to be essential proteins
Phase 4: April 2009
2DQ3
57.8%
Bacillus anthracis
IDP05099
(
show subtarget assignments
)
1
cloned
No
CD0754
126698334
thiI
thiamine biosynthesis protein ThiI [Clos...
391
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2C5S
42.2%
Clostridium difficile
Protein synthesis: tRNA and rRNA base modification
IDP04573
(
show subtarget assignments
)
1
crystallized
No
BAS0006
49183045
DNA gyrase subunit A [Bacillus anthracis...
823
Proposed to be essential proteins
Phase 4: April 2009
2XCO
42.9%
Bacillus anthracis
IDP04577
(
show subtarget assignments
)
1
cloned
No
BAS0087
49183121
glutamyl-tRNA synthetase [Bacillus anthr...
485
Proposed to be essential proteins
Phase 4: April 2009
2O5R
44.4%
Bacillus anthracis
IDP04579
(
show subtarget assignments
)
1
cloned
No
BAS0098
49183132
50S ribosomal protein L1 [Bacillus anthr...
230
Proposed to be essential proteins
Phase 4: April 2009
3QOY
56.3%
Bacillus anthracis
IDP04578
(
show subtarget assignments
)
1
cloned
No
BAS0089
49183123
cysteinyl-tRNA synthetase [Bacillus anth...
465
Proposed to be essential proteins
Phase 4: April 2009
1LI5
45.6%
Bacillus anthracis
IDP04582
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0110
49183144
50S ribosomal protein L3 [Bacillus anthr...
210
Proposed to be essential proteins
Phase 4: April 2009
1NKW
53.3%
Bacillus anthracis
IDP04581
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0108
49183142
elongation factor Tu [Bacillus anthracis...
395
Proposed to be essential proteins
Phase 4: April 2009
3U2Q
75.4%
Bacillus anthracis
IDP05229
(
show subtarget assignments
)
1
cloned
No
lmo1286
16803326
parE
DNA topoisomerase IV subunit B [Listeria...
655
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1EI1
29.8%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP04580
(
show subtarget assignments
)
1
cloned
No
BAS0103
49183137
DNA-directed RNA polymerase subunit beta...
1203
Proposed to be essential proteins
Phase 4: April 2009
2GHO
53.6%
Bacillus anthracis
IDP04605
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3689
49186688
ribosomal biogenesis GTPase [Bacillus an...
296
Proposed to be essential proteins
Phase 4: April 2009
1PUJ
67.2%
Bacillus anthracis
IDP04587
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0118
49183152
50S ribosomal protein L29 [Bacillus anth...
66
Proposed to be essential proteins
Phase 4: April 2009
1R73
45.5%
Bacillus anthracis
IDP04583
(
show subtarget assignments
)
1
cloned
No
BAS0111
49183145
50S ribosomal protein L4 [Bacillus anthr...
207
Proposed to be essential proteins
Phase 4: April 2009
1DMG
47.1%
Bacillus anthracis
IDP05183
(
show subtarget assignments
)
1
soluble
No
BA_5237
30259716
putative lipoprotein [Bacillus anthracis...
176
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05135
(
show subtarget assignments
)
1
soluble
No
CD0855
126698435
oppA
oligopeptide ABC transporter, substrate-...
522
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1XOC
33.1%
Clostridium difficile
Transport and binding proteins: Amino acids, peptides and amines
IDP05221
(
show subtarget assignments
)
1
expressed
No
BA_4349
30258849
hypothetical protein BA_4349 [Bacillus a...
62
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04586
(
show subtarget assignments
)
1
cloned
No
BAS0117
49183151
50S ribosomal protein L16 [Bacillus anth...
144
Proposed to be essential proteins
Phase 4: April 2009
1VSA
60.4%
Bacillus anthracis
IDP04585
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0116
49183150
30S ribosomal protein S3 [Bacillus anthr...
219
Proposed to be essential proteins
Phase 4: April 2009
1VS5
54.3%
Bacillus anthracis
IDP04584
(
show subtarget assignments
)
1
purified
No
BAS0112
49183146
50S ribosomal protein L23 [Bacillus anth...
96
Proposed to be essential proteins
Phase 4: April 2009
1N88
43.8%
Bacillus anthracis
IDP04591
(
show subtarget assignments
)
1
cloned
No
BAS0138
49183172
50S ribosomal protein L17 [Bacillus anth...
120
Proposed to be essential proteins
Phase 4: April 2009
1NKW
50.8%
Bacillus anthracis
IDP04258
(
show subtarget assignments
)
1
soluble
No
CPF_2010
110801347
sensory box histidine kinase [Clostridiu...
571
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
17.3%
Clostridium perfringens
Regulatory functions
IDP05182
(
show subtarget assignments
)
1
soluble
No
BA_4984
30259476
gerHA
spore germination protein GerHA [Bacillu...
747
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3FBY
7.5%
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP04222
(
show subtarget assignments
)
8
selected
No
CAC05827
12329096
spa33
Spa33, component of the Mxi-Spa secretio...
293
Shigella effector protein
Community Requests
Shigella flexneri
IDP04598
(
show subtarget assignments
)
1
cloned
No
BAS1442
49184459
dihydrodipicolinate reductase [Bacillus ...
266
Proposed to be essential proteins
Phase 4: April 2009
1C3V
40.6%
Bacillus anthracis
IDP04589
(
show subtarget assignments
)
1
expressed
No
BAS0135
49183169
30S ribosomal protein S13 [Bacillus anth...
121
Proposed to be essential proteins
Phase 4: April 2009
1FJG
63.9%
Bacillus anthracis
IDP04590
(
show subtarget assignments
)
1
expressed
No
BAS0136
49183170
30S ribosomal protein S11 [Bacillus anth...
129
Proposed to be essential proteins
Phase 4: April 2009
1VS5
65.9%
Bacillus anthracis
IDP05100
(
show subtarget assignments
)
1
soluble
No
CD0876
126698453
ABC transporter, substrate-binding lipop...
345
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3LFT
32.2%
Clostridium difficile
Transport and binding proteins: Amino acids, peptides and amines
IDP04593
(
show subtarget assignments
)
1
cloned
No
BAS0144
49183178
30S ribosomal protein S9 [Bacillus anthr...
130
Proposed to be essential proteins
Phase 4: April 2009
1VS5
55.4%
Bacillus anthracis
IDP04597
(
show subtarget assignments
)
1
expressed
No
BAS1384
49184401
resB protein [Bacillus anthracis str. St...
541
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04592
(
show subtarget assignments
)
1
expressed
No
BAS0143
49183177
50S ribosomal protein L13 [Bacillus anth...
145
Proposed to be essential proteins
Phase 4: April 2009
1P85
56.6%
Bacillus anthracis
IDP04218
(
show subtarget assignments
)
1
expressed
No
STM2996_1_1123
16766298
recC
exonuclease V subunit gamma [Salmonella ...
1123
Salmonella essential protein
Phase 4: April 2009
1W36
88.4%
Salmonella enterica
IDP04596
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS1099
49184119
tryptophanyl-tRNA synthetase [Bacillus a...
329
Proposed to be essential proteins
Phase 4: April 2009
3PRH
73.9%
Bacillus anthracis
IDP04595
(
show subtarget assignments
)
1
soluble
No
BAS0565
49183590
nicotinate phosphoribosyltransferase [Ba...
487
Proposed to be essential proteins
Phase 4: April 2009
2F7F
61.4%
Bacillus anthracis
IDP05291
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD1211
126698807
putative acetyltransferase [Clostridium ...
163
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
1YX0
23.9%
Clostridium difficile
Cellular processes: Toxin production and resistance
IDP05292
(
show subtarget assignments
)
1
cloned
No
CD1600
126699204
thiK
hydroxyethylthiazole kinase [Clostridium...
262
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3HPD
35.5%
Clostridium difficile
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
IDP04219
(
show subtarget assignments
)
1
cloned
No
STM3148_1_392
16766448
hybB
putative hydrogenase 2 b cytochrome subu...
392
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP04599
(
show subtarget assignments
)
1
cloned
No
BAS2268
49185277
aspartate-semialdehyde dehydrogenase [Ba...
347
Proposed to be essential proteins
Phase 4: April 2009
2GYY
55.3%
Bacillus anthracis
IDP05225
(
show subtarget assignments
)
1
cloned
No
lmo0415
16802459
-
hypothetical protein lmo0415 [Listeria m...
466
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2C1G
29%
Listeria monocytogenes
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05508
(
show subtarget assignments
)
1
cloned
No
BA_5398
30259871
putative lipoprotein [Bacillus anthracis...
143
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP05627
(
show subtarget assignments
)
1
soluble
No
CD1406
126699009
hypothetical protein CD1406 [Clostridium...
268
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Hypothetical proteins: Conserved
IDP04221
(
show subtarget assignments
)
1
expressed
No
STM4262_1_688
16767512
putative ABC-type bacteriocin/lantibioti...
688
Salmonella essential protein
Phase 4: April 2009
3G5U
21.5%
Salmonella enterica
IDP05140
(
show subtarget assignments
)
1
soluble
No
BAS0382
49183410
-
prolyl-tRNA synthetase [Bacillus anthrac...
508
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1H4Q
48.2%
Bacillus anthracis
Protein synthesis: tRNA aminoacylation
IDP04600
(
show subtarget assignments
)
1
cloned
No
BAS2547
49185555
preprotein translocase subunit SecY [Bac...
434
Proposed to be essential proteins
Phase 4: April 2009
3DIN
42.2%
Bacillus anthracis
IDP05293
(
show subtarget assignments
)
1
cloned
No
CD1408
126699011
ddl
D-alanine--D-alanine ligase [Clostridium...
299
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3R23
51.5%
Clostridium difficile
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05226
(
show subtarget assignments
)
1
cloned
No
lmo0460
16802504
-
putative membrane associated lipoprotein...
689
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3RGX
11.8%
Listeria monocytogenes
Hypothetical proteins: Conserved
IDP04603
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3670
49186669
prolyl-tRNA synthetase [Bacillus anthrac...
566
Proposed to be essential proteins
Phase 4: April 2009
2J3L
58.1%
Bacillus anthracis
IDP05227
(
show subtarget assignments
)
1
soluble
No
lmo0541
16802584
-
hypothetical protein lmo0541 [Listeria m...
306
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3EIW
28.1%
Listeria monocytogenes
Transport and binding proteins: Cations and iron carrying compounds
IDP05628
(
show subtarget assignments
)
1
soluble
No
CD1444
126699048
putative exported polysaccharide deacety...
239
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2C1G
32.6%
Clostridium difficile
Unknown function: General
IDP04602
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS3667
49186666
transcription elongation factor NusA [Ba...
368
Proposed to be essential proteins
Phase 4: April 2009
1HH2
44%
Bacillus anthracis
IDP04601
(
show subtarget assignments
)
1
in_pdb
3RHI
Yes
BAS3574
49186575
DNA-binding protein HU [Bacillus anthrac...
90
Proposed to be essential proteins
Phase 4: April 2009
3RHI
100%
Bacillus anthracis
IDP05300
(
show subtarget assignments
)
1
cloned
No
VC_0631
9655066
tyrosyl-tRNA synthetase [Vibrio cholerae...
395
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1H3E
47.8%
Vibrio cholerae
Protein synthesis: tRNA aminoacylation
IDP05145
(
show subtarget assignments
)
1
soluble
No
BAS4679
49187670
-
hypothetical protein BAS4679 [Bacillus a...
357
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP05236
(
show subtarget assignments
)
1
crystallized
No
lmo1533
16803573
ruvA
hypothetical protein lmo1533 [Listeria m...
201
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1IXR
34.8%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP05149
(
show subtarget assignments
)
1
purified
No
BA_0194
30253701
putative oligopeptide ABC transporter, o...
546
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1B05
30.2%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP04612
(
show subtarget assignments
)
1
cloned
No
BAS3764
49186763
phospho-N-acetylmuramoyl-pentapeptide-tr...
324
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP04618
(
show subtarget assignments
)
1
cloned
No
BAS4456
49187451
phenylalanyl-tRNA synthetase subunit alp...
344
Proposed to be essential proteins
Phase 4: April 2009
2RHQ
57.6%
Bacillus anthracis
IDP05339
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1622
57651958
glyS
glycyl-tRNA synthetase [Staphylococcus a...
463
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1ATI
41.9%
Staphylococcus aureus
Protein synthesis: tRNA aminoacylation
IDP05232
(
show subtarget assignments
)
1
in_pdb
3TX1
No
lmo1420
16803460
-
hypothetical protein lmo1420 [Listeria m...
298
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3TX1
100%
Listeria monocytogenes
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05332
(
show subtarget assignments
)
1
soluble
No
Z4866
12518154
putative beta-ketoacyl-ACP synthase [Esc...
409
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
4EWG
59.7%
Escherichia coli
Fatty acid and phospholipid metabolism: Biosynthesis
IDP05107
(
show subtarget assignments
)
1
soluble
No
CD1751
126699358
cell surface protein (putative cell surf...
795
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1VSN
8.4%
Clostridium difficile
Cell envelope: Other
IDP05500
(
show subtarget assignments
)
1
cloned
No
CD0261
126697833
fliQ
flagellar export protein [Clostridium di...
89
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04349
(
show subtarget assignments
)
1
expressed
No
STM0557_1_550
16763935
putative inner membrane protein [Salmone...
550
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05243
(
show subtarget assignments
)
1
crystallized
No
lmo2198
16804237
trpS
tryptophanyl-tRNA synthetase [Listeria m...
331
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3PRH
72.2%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP05154
(
show subtarget assignments
)
1
soluble
No
BA_0796
30254387
conserved hypothetical protein [Bacillus...
386
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP04074
(
show subtarget assignments
)
1
cloned
No
BAS4469
49187464
50S ribosomal protein L20 [Bacillus anth...
118
Proposed to be essential proteins
Phase 4: April 2009
1VS6
55.1%
Bacillus anthracis
IDP04633
(
show subtarget assignments
)
1
in_pdb
4EEI
No
FTT0015
56707195
purB
adenylosuccinate lyase [Francisella tula...
432
conserved gene; putative drug target function;
Phase 4: April 2009
4EEI
100%
Francisella tularensis
IDP05196
(
show subtarget assignments
)
1
cloned
No
CD0961
126698545
putative phage cell wall hydrolase [Clos...
656
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3H41
8.1%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP04055
(
show subtarget assignments
)
1
cloned
No
STM0301_1_836
16763684
safC
putative fimbrial usher [Salmonella typh...
836
Salmonella essential protein
Phase 4: April 2009
3RFZ
37%
Salmonella enterica
IDP04610
(
show subtarget assignments
)
1
in_pdb
3RFO
No
BAS3717
49186716
methionyl-tRNA formyltransferase [Bacill...
314
Proposed to be essential proteins
Phase 4: April 2009
3RFO
100%
Bacillus anthracis
IDP04611
(
show subtarget assignments
)
1
cloned
No
BAS3754
49186753
sporulation sigma factor SigG [Bacillus ...
289
Proposed to be essential proteins
Phase 4: April 2009
1L0O
37%
Bacillus anthracis
IDP91373
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_2221
27365547
acetate kinase [Vibrio vulnificus CMCP6]...
398
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2IIR
47.4%
Vibrio vulnificus
IDP91372
(
show subtarget assignments
)
8
cloned
No
VV1_2222
27365548
hypothetical protein VV1_2222 [Vibrio vu...
150
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
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