Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02645 (show subtarget assignments)	1	soluble	No	STM1749	16765093	adhE	bifunctional acetaldehyde-CoA/alcohol de...	892	Conserved; Essential; Drug target functions	Phase 3: June 2008	3MY7	38.7%	Salmonella enterica	Energy metabolism	Fermentation

IDP01818 (show subtarget assignments)	1	soluble	No	GBAA5444	47530758	celA-2	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	42%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01605 (show subtarget assignments)	1	soluble	No	GBAA4560	47529856		hypothetical protein GBAA4560 [Bacillus ...	97	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1RQ8	67%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP02499 (show subtarget assignments)	1	in_pdb 3I3O 3IJR	No	GBAA0748	47526031		short chain dehydrogenase [Bacillus anth...	288	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3I3O	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01723 (show subtarget assignments)	1	in_pdb 3KAX	No	GBAA5138	47530443		aminotransferase, classes I and II [Baci...	383	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3KAX	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01672 (show subtarget assignments)	1	soluble	No	GBAA5133	47530438		hypothetical protein GBAA5133 [Bacillus ...	396	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1DJU	48.2%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02727 (show subtarget assignments)	1	crystallized	No	GBAA4249	47778264		3-hydroxybutyrate dehydrogenase [Bacillu...	258	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3V2H	42.6%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02370 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1958	47527254	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	242	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3OEC	40.9%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP01639 (show subtarget assignments)	1	cloned	No	GBAA4225	47529518		aminotransferase A [Bacillus anthracis s...	387	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1GD9	39.5%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02325 (show subtarget assignments)	1	in_pdb 3IMF	No	GBAA4204	47778260		short chain dehydrogenase [Bacillus anth...	254	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3IMF	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02573 (show subtarget assignments)	1	in_pdb 3ICC	No	GBAA1847	47527139		short chain dehydrogenase [Bacillus anth...	252	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3ICC	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02826 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4254	47529547		transaminase [Bacillus anthracis str. 'A...	392	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	2O1B	40.8%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02163 (show subtarget assignments)	1	cloned	No	GBAA3914	47529205		phosphodiesterase [Bacillus anthracis st...	520	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008			Bacillus anthracis	Unknown function	General

IDP01681 (show subtarget assignments)	1	cloned	No	GBAA4795	47530092		hypothetical protein GBAA4795 [Bacillus ...	572	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3AU2	37.1%	Bacillus anthracis	Unknown function	General

IDP02524 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1852	47527143	ilvC-2	ketol-acid reductoisomerase [Bacillus an...	335	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1NP3	56.1%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP02533 (show subtarget assignments)	1	expressed	No	GBAA4184	47529480	pdhA	pyruvate dehydrogenase complex E1 compon...	371	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	80.9%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP01606 (show subtarget assignments)	1	cloned	No	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP01892 (show subtarget assignments)	1	in_pdb 3HVU 3KB8 3H83	No	GBAA0063	47525317	hpt-1	hypoxanthine-guanine phosphoribosyltrans...	180	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3H83	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01922 (show subtarget assignments)	1	expressed	No	GBAA1441	47526716	sat	sulfate adenylyltransferase [Bacillus an...	378	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1V47	39.4%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP02496 (show subtarget assignments)	1	expressed	No	GBAA4183	47529479	pdhB	pyruvate dehydrogenase complex E1 compon...	325	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	85.8%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP02781 (show subtarget assignments)	1	in_pdb 3K28	No	GBAA4693	47529992	hemL-2	glutamate-1-semialdehyde aminotransferas...	429	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K28	100%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02478 (show subtarget assignments)	1	cloned	No	GBAA4182	47529478	pdhC	branched-chain alpha-keto acid dehydroge...	419	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	74.7%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP01876 (show subtarget assignments)	1	cloned	No	GBAA0095	47525349	secE	preprotein translocase subunit SecE [Bac...	59	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DIN	33.9%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02480 (show subtarget assignments)	1	cloned	No	GBAA5700	47531036	galE-2	UDP-glucose 4-epimerase [Bacillus anthra...	338	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3ENK	58.6%	Bacillus anthracis	Energy metabolism	Sugars

IDP02782 (show subtarget assignments)	0	work_stopped	No	GBAA4874	161611196	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	252	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4F	94.8%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02467 (show subtarget assignments)	1	soluble	No	GBAA3937	47529228	asd-2	aspartate-semialdehyde dehydrogenase [Ba...	348	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2GYY	60.6%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01831 (show subtarget assignments)	1	cloned	No	GBAA3985	47529275	ftsY	signal recognition particle-docking prot...	329	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VMA	48.6%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02664 (show subtarget assignments)	1	purified	No	GBAA5387	47778397	trxB	thioredoxin reductase [Bacillus anthraci...	318	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2Q7V	47.5%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02454 (show subtarget assignments)	1	in_pdb 3HYL 3M49	No	GBAA3744	47529034	tkt-2	transketolase [Bacillus anthracis str. '...	666	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3HYL	100%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP02668 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1526	47526800	gpsA	NAD(P)H-dependent glycerol-3-phosphate d...	340	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1Z82	42.9%	Bacillus anthracis	Energy metabolism	Other

IDP02374 (show subtarget assignments)	1	purified	No	GBAA3116	47528407	ppsA	phosphoenolpyruvate synthase [Bacillus a...	868	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OLS	15.7%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02725 (show subtarget assignments)	1	crystallized	No	GBAA4341	47529638	bioA	adenosylmethionine--8-amino-7-oxononanoa...	462	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DOD	57.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02332 (show subtarget assignments)	1	purified	No	GBAA1462	47526735		UbiE/COQ5 family methlytransferase [Baci...	258	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UJD	22.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02328 (show subtarget assignments)	1	expressed	No	GBAA2548	47527837		acetyl-CoA carboxylase biotin carboxylas...	445	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N6R	51.9%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02329 (show subtarget assignments)	1	in_pdb 3KQF	Yes	GBAA2551	47527840		enoyl-CoA hydratase [Bacillus anthracis ...	262	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3KQF	100%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP02315 (show subtarget assignments)	1	cloned	No	GBAA1132	47526402	aceA	isocitrate lyase [Bacillus anthracis str...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I4E	71.4%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP02642 (show subtarget assignments)	1	cloned	No	GBAA5626	47778419		4-oxalocrotonate tautomerase [Bacillus a...	61	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OP8	78.7%	Bacillus anthracis	Energy metabolism	Other

IDP02635 (show subtarget assignments)	1	soluble	No	GBAA5421	47530734	secA	preprotein translocase subunit SecA [Bac...	835	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TF2	72.8%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP02807 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4705	47530004	tig	trigger factor [Bacillus anthracis str. ...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T11	32.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP02643 (show subtarget assignments)	1	in_pdb 3RUY	No	GBAA1154	47526421	rocD	ornithine--oxo-acid transaminase [Bacill...	396	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3RUY	98.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02748 (show subtarget assignments)	1	expressed	No	GBAA4408	47529702	accC	acetyl-CoA carboxylase biotin carboxylas...	450	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VPQ	66.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02245 (show subtarget assignments)	1	cloned	No	GBAA1751	47527043	asnO-2	asparagine synthetase, glutamine-hydroly...	607	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1CT9	25.9%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP02745 (show subtarget assignments)	1	cloned	No	GBAA4384	47529679	bfmbAa	3-methyl-2-oxobutanoate dehydrogenase, a...	333	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	41.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02743 (show subtarget assignments)	1	cloned	No	GBAA4383	47529678	bfmbAb	3-methyl-2-oxobutanoate dehydrogenase, b...	327	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	52.9%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02829 (show subtarget assignments)	1	cloned	No	GBAA4382	47529677	bfmbB	branched-chain alpha-keto acid dehydroge...	439	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.4%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02080 (show subtarget assignments)	1	in_pdb 3KZ2 3IH1	No	GBAA2350	47527645	yqiQ	carboxyvinyl-carboxyphosphonate phosphor...	302	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IH1	100%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02549 (show subtarget assignments)	1	purified	No	GBAA0547	47525820		RNA methyltransferase [Bacillus anthraci...	162	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3L8U	51.2%	Bacillus anthracis	Protein synthesis	tRNA and rRNA base modification

IDP01865 (show subtarget assignments)	1	in_pdb 3Q94	No	GBAA5580	47530901	fba-2	fructose-bisphosphate aldolase [Bacillus...	285	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3Q94	100%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02729 (show subtarget assignments)	1	in_pdb 3SS6	Yes	GBAA4240	47529533		acetyl-CoA acetyltransferase [Bacillus a...	391	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3SS6	99.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Other

IDP04292 (show subtarget assignments)	1	cloned	No	YPO0812	218927992		general secretion pathway protein H [Yer...	180	conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP04658 (show subtarget assignments)	1	purified	No	FTT1736c	56708739	kdpD	two component sensor protein kdpD [Franc...	893	conserved gene;	Phase 4: April 2009	2R8R	11.4%	Francisella tularensis

IDP04644 (show subtarget assignments)	1	cloned	No	FTT0895	56707996	purN	phosphoribosylglycinamide formyltransfer...	191	conserved gene;	Phase 4: April 2009	1C2T	40.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04643 (show subtarget assignments)	1	in_pdb 3M84 3QTY	No	FTT0893	56707994	purM	phosphoribosylaminoimidazole synthetase ...	347	conserved gene;	Phase 4: April 2009	3M84	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04631 (show subtarget assignments)	1	cloned	No	CBU_1891	215919282	pilQ	type II and III secretion system family ...	353	conserved gene;	Phase 4: April 2009			Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP04312 (show subtarget assignments)	1	cloned	No	FTT0204	56707368	purA	adenylosuccinate synthetase [Francisella...	428	conserved gene;	Phase 4: April 2009	1ADE	45.9%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90226 (show subtarget assignments)	1	selected	No	VC2428	9657003		conserved hypothetical protein [Vibrio c...	246	Conserved gene clusters with virulence associated genes. Conserved Protein; Pred...	January 2009	2OEZ	74.8%	Vibrio cholerae

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01129 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5296	30259774		ferritin	168	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	48.2%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00588 (show subtarget assignments)	1	purified	No	YPO2077	16122316	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	87.8%	Yersinia pestis	Cellular processes	Cell division

IDP01126 (show subtarget assignments)	1	cloned	No	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01124 (show subtarget assignments)	1	purified	No	BA_4938	33301353		UDP-N-acetylmuramate--L-alanine ligase (...	436	Conserved Gene / Pathway	Phase 2: March 2008	1J6U	30.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01123 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4267	30258769	ptsI	phosphoenolpyruvate-protein phosphotrans...	570	Conserved Gene / Pathway	Phase 2: March 2008	2HRO	65.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01122 (show subtarget assignments)	1	soluble	No	BA_4045	30258552	ftsZ	cell division protein FtsZ	386	Conserved Gene / Pathway	Phase 2: March 2008	2VAM	78.1%	Bacillus anthracis	Cellular processes	Cell division

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01120 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1194	30254907		oligopeptide ABC transporter, ATP-bindin...	347	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01119 (show subtarget assignments)	1	purified	No	BA_0344	30253882	ahpF	alkyl hydroperoxide reductase, F subunit...	508	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	55.7%	Bacillus anthracis	Cellular processes	Detoxification

IDP01118 (show subtarget assignments)	1	crystallized	No	BA_4030	81837831		Bifunctional protein pyrR [Includes: Pyr...	180	Conserved Gene / Pathway	Phase 2: March 2008	1A3C	73.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01117 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3754	33301235		LexA repressor	206	Conserved Gene / Pathway	Phase 2: March 2008	3K2Z	38.3%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP00582 (show subtarget assignments)	1	in_pdb 3GSE	Yes	YPO2528	16122747	menF	menaquinone-specific isochorismate synth...	455	Conserved Gene / Pathway	Phase 2: March 2008	3GSE	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01114 (show subtarget assignments)	1	soluble	No	BA_4901	38502945		Septation ring formation regulator ezrA	570	Conserved Gene / Pathway	Phase 2: March 2008			Bacillus anthracis	Cellular processes	Cell division

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01112 (show subtarget assignments)	1	in_pdb 3G48	No	BA_2064	30256713	csaA	chaperone CsaA	109	Conserved Gene / Pathway	Phase 2: March 2008	3G48	99.1%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01111 (show subtarget assignments)	1	cloned	No	BA_1135	49035527		Major cold shock protein cspA	67	Conserved Gene / Pathway	Phase 2: March 2008	1CSP	73.1%	Bacillus anthracis	Cellular processes	Adaptations to atypical conditions

IDP00580 (show subtarget assignments)	1	purified	No	YPO0059	16120412	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	403	Conserved Gene / Pathway	Phase 2: March 2008	1FC4	82.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01110 (show subtarget assignments)	1	in_pdb 3RYK	Yes	BA_1229	30255178	rfbC	dTDP-4-dehydrorhamnose 3,5-epimerase	181	Conserved Gene / Pathway	Phase 2: March 2008	3RYK	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00579 (show subtarget assignments)	1	cloned	No	YPO1122	16121422	tolR	colicin uptake protein TolR	142	Conserved Gene / Pathway	Phase 2: March 2008	2JWK	23.9%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01108 (show subtarget assignments)	1	in_pdb	No	BA_3860	30258377		copper-ion-binding protein	68	Conserved Gene / Pathway	Phase 2: March 2008	2L3M	100%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01107 (show subtarget assignments)	1	soluble	No	BA_2250	30256894		heat shock protein, Hsp20 family	153	Conserved Gene / Pathway	Phase 2: March 2008	3AAB	24.2%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01106 (show subtarget assignments)	1	soluble	No	BA_1846	30256116	msrA-1	peptide methionine sulfoxide reductase	178	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	36%	Bacillus anthracis	Protein fate	Protein modification and repair

IDP01104 (show subtarget assignments)	1	soluble	No	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01520 (show subtarget assignments)	1	expressed	No	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01100 (show subtarget assignments)	1	in_pdb 3K1S	No	BA_5442	30259910	celC-2	PTS system, cellobiose-specific IIA comp...	107	Conserved Gene / Pathway	Phase 2: March 2008	3K1S	99.1%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01091 (show subtarget assignments)	1	in_crystallization_trials	No	STM4578	16767819	serB	phosphoserine phosphatase	322	Conserved Gene / Pathway	Phase 2: March 2008	3N28	47.2%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP01090 (show subtarget assignments)	0	work_stopped	No	STM4567	16767808	deoC	deoxyribose-phosphate aldolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1JCL	94.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP01089 (show subtarget assignments)	1	soluble	No	STM4533	16767777	tsr	methyl-accepting chemotaxis protein I	553	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	49.5%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01087 (show subtarget assignments)	1	cloned	No	STM4465	16767710		ornithine carbamoyltransferase	334	Conserved Gene / Pathway	Phase 2: March 2008	3UPD	75.7%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP01086 (show subtarget assignments)	1	in_crystallization_trials	No	STM4404	16767650	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphos...	246	Conserved Gene / Pathway	Phase 2: March 2008	3B8B	48.1%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP01085 (show subtarget assignments)	1	in_crystallization_trials	No	STM4397	161353572	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans...	206	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP01084 (show subtarget assignments)	1	purified	No	STM4377	161353573	aidB	putative acyl-CoA dehydrogenase	546	Conserved Gene / Pathway	Phase 2: March 2008	3DJL	84.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01083 (show subtarget assignments)	1	in_pdb 3OPK	No	STM4324	16767573	cutA	divalent-cation tolerance protein CutA	115	Conserved Gene / Pathway	Phase 2: March 2008	3OPK	100%	Salmonella enterica	Cellular processes	Detoxification

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP01081 (show subtarget assignments)	1	soluble	No	STM4267	16767517		putative glutathione S-transferase	222	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	28.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01080 (show subtarget assignments)	0	work_stopped	No	STM4220	16767470	lysC	aspartate kinase III	449	Conserved Gene / Pathway	Phase 2: March 2008	2J0W	93.1%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP00568 (show subtarget assignments)	0	work_stopped	No	YPO0106	16120453	hslV	ATP-dependent protease peptidase subunit...	174	Conserved Gene / Pathway	Phase 2: March 2008	1E94	90.2%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00731 (show subtarget assignments)	1	purified	No	SACOL2462	57286457		ABC transporter, ATP-binding protein	220	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	35.5%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01518 (show subtarget assignments)	1	purified	No	VC1512	15641521		formate dehydrogenase, iron-sulfur subun...	202	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	29%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP01077 (show subtarget assignments)	0	work_stopped	No	STM4122	161353577	argB	acetylglutamate kinase	257	Conserved Gene / Pathway	Phase 2: March 2008	1GS5	94.2%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP02645
(show subtarget assignments)

1

soluble

No

STM1749

16765093

adhE

bifunctional acetaldehyde-CoA/alcohol de...

892

Conserved; Essential; Drug target functions

Phase 3: June 2008

3MY7

38.7%

Salmonella enterica

Energy metabolism

Fermentation

IDP01818
(show subtarget assignments)

1

soluble

No

GBAA5444

47530758

celA-2

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

42%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01605
(show subtarget assignments)

1

soluble

No

GBAA4560

47529856

hypothetical protein GBAA4560 [Bacillus ...

97

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1RQ8

67%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP02499
(show subtarget assignments)

1

in_pdb
3I3O
3IJR

No

GBAA0748

47526031

short chain dehydrogenase [Bacillus anth...

288

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3I3O

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01723
(show subtarget assignments)

1

in_pdb
3KAX

No

GBAA5138

47530443

aminotransferase, classes I and II [Baci...

383

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3KAX

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01672
(show subtarget assignments)

1

soluble

No

GBAA5133

47530438

hypothetical protein GBAA5133 [Bacillus ...

396

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1DJU

48.2%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02727
(show subtarget assignments)

1

crystallized

No

GBAA4249

47778264

3-hydroxybutyrate dehydrogenase [Bacillu...

258

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3V2H

42.6%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02370
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1958

47527254

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

242

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3OEC

40.9%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP01639
(show subtarget assignments)

1

cloned

No

GBAA4225

47529518

aminotransferase A [Bacillus anthracis s...

387

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1GD9

39.5%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02325
(show subtarget assignments)

1

in_pdb
3IMF

No

GBAA4204

47778260

short chain dehydrogenase [Bacillus anth...

254

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3IMF

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02573
(show subtarget assignments)

1

in_pdb
3ICC

No

GBAA1847

47527139

short chain dehydrogenase [Bacillus anth...

252

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3ICC

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02826
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4254

47529547

transaminase [Bacillus anthracis str. 'A...

392

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

2O1B

40.8%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02163
(show subtarget assignments)

1

cloned

No

GBAA3914

47529205

phosphodiesterase [Bacillus anthracis st...

520

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

Bacillus anthracis

Unknown function

General

IDP01681
(show subtarget assignments)

1

cloned

No

GBAA4795

47530092

hypothetical protein GBAA4795 [Bacillus ...

572

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3AU2

37.1%

Bacillus anthracis

Unknown function

General

IDP02524
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1852

47527143

ilvC-2

ketol-acid reductoisomerase [Bacillus an...

335

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1NP3

56.1%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP02533
(show subtarget assignments)

1

expressed

No

GBAA4184

47529480

pdhA

pyruvate dehydrogenase complex E1 compon...

371

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

80.9%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP01606
(show subtarget assignments)

1

cloned

No

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP01892
(show subtarget assignments)

1

in_pdb
3HVU
3KB8
3H83

No

GBAA0063

47525317

hpt-1

hypoxanthine-guanine phosphoribosyltrans...

180

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3H83

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01922
(show subtarget assignments)

1

expressed

No

GBAA1441

47526716

sat

sulfate adenylyltransferase [Bacillus an...

378

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1V47

39.4%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP02496
(show subtarget assignments)

1

expressed

No

GBAA4183

47529479

pdhB

pyruvate dehydrogenase complex E1 compon...

325

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

85.8%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP02781
(show subtarget assignments)

1

in_pdb
3K28

No

GBAA4693

47529992

hemL-2

glutamate-1-semialdehyde aminotransferas...

429

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K28

100%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02478
(show subtarget assignments)

1

cloned

No

GBAA4182

47529478

pdhC

branched-chain alpha-keto acid dehydroge...

419

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

74.7%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP01876
(show subtarget assignments)

1

cloned

No

GBAA0095

47525349

secE

preprotein translocase subunit SecE [Bac...

59

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DIN

33.9%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02480
(show subtarget assignments)

1

cloned

No

GBAA5700

47531036

galE-2

UDP-glucose 4-epimerase [Bacillus anthra...

338

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3ENK

58.6%

Bacillus anthracis

Energy metabolism

Sugars

IDP02782
(show subtarget assignments)

0

work_stopped

No

GBAA4874

161611196

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

252

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4F

94.8%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02467
(show subtarget assignments)

1

soluble

No

GBAA3937

47529228

asd-2

aspartate-semialdehyde dehydrogenase [Ba...

348

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2GYY

60.6%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01831
(show subtarget assignments)

1

cloned

No

GBAA3985

47529275

ftsY

signal recognition particle-docking prot...

329

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VMA

48.6%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02664
(show subtarget assignments)

1

purified

No

GBAA5387

47778397

trxB

thioredoxin reductase [Bacillus anthraci...

318

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2Q7V

47.5%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02454
(show subtarget assignments)

1

in_pdb
3HYL
3M49

No

GBAA3744

47529034

tkt-2

transketolase [Bacillus anthracis str. '...

666

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3HYL

100%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP02668
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1526

47526800

gpsA

NAD(P)H-dependent glycerol-3-phosphate d...

340

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1Z82

42.9%

Bacillus anthracis

Energy metabolism

Other

IDP02374
(show subtarget assignments)

1

purified

No

GBAA3116

47528407

ppsA

phosphoenolpyruvate synthase [Bacillus a...

868

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OLS

15.7%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02725
(show subtarget assignments)

1

crystallized

No

GBAA4341

47529638

bioA

adenosylmethionine--8-amino-7-oxononanoa...

462

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DOD

57.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02332
(show subtarget assignments)

1

purified

No

GBAA1462

47526735

UbiE/COQ5 family methlytransferase [Baci...

258

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UJD

22.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02328
(show subtarget assignments)

1

expressed

No

GBAA2548

47527837

acetyl-CoA carboxylase biotin carboxylas...

445

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N6R

51.9%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02329
(show subtarget assignments)

1

in_pdb
3KQF

Yes

GBAA2551

47527840

enoyl-CoA hydratase [Bacillus anthracis ...

262

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3KQF

100%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP02315
(show subtarget assignments)

1

cloned

No

GBAA1132

47526402

aceA

isocitrate lyase [Bacillus anthracis str...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I4E

71.4%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP02642
(show subtarget assignments)

1

cloned

No

GBAA5626

47778419

4-oxalocrotonate tautomerase [Bacillus a...

61

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OP8

78.7%

Bacillus anthracis

Energy metabolism

Other

IDP02635
(show subtarget assignments)

1

soluble

No

GBAA5421

47530734

secA

preprotein translocase subunit SecA [Bac...

835

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TF2

72.8%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP02807
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4705

47530004

tig

trigger factor [Bacillus anthracis str. ...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T11

32.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP02643
(show subtarget assignments)

1

in_pdb
3RUY

No

GBAA1154

47526421

rocD

ornithine--oxo-acid transaminase [Bacill...

396

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3RUY

98.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02748
(show subtarget assignments)

1

expressed

No

GBAA4408

47529702

accC

acetyl-CoA carboxylase biotin carboxylas...

450

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VPQ

66.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02245
(show subtarget assignments)

1

cloned

No

GBAA1751

47527043

asnO-2

asparagine synthetase, glutamine-hydroly...

607

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1CT9

25.9%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP02745
(show subtarget assignments)

1

cloned

No

GBAA4384

47529679

bfmbAa

3-methyl-2-oxobutanoate dehydrogenase, a...

333

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

41.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02743
(show subtarget assignments)

1

cloned

No

GBAA4383

47529678

bfmbAb

3-methyl-2-oxobutanoate dehydrogenase, b...

327

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

52.9%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02829
(show subtarget assignments)

1

cloned

No

GBAA4382

47529677

bfmbB

branched-chain alpha-keto acid dehydroge...

439

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.4%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02080
(show subtarget assignments)

1

in_pdb
3KZ2
3IH1

No

GBAA2350

47527645

yqiQ

carboxyvinyl-carboxyphosphonate phosphor...

302

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IH1

100%

Bacillus anthracis

Central intermediary metabolism

Other

IDP02549
(show subtarget assignments)

1

purified

No

GBAA0547

47525820

RNA methyltransferase [Bacillus anthraci...

162

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3L8U

51.2%

Bacillus anthracis

Protein synthesis

tRNA and rRNA base modification

IDP01865
(show subtarget assignments)

1

in_pdb
3Q94

No

GBAA5580

47530901

fba-2

fructose-bisphosphate aldolase [Bacillus...

285

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3Q94

100%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02729
(show subtarget assignments)

1

in_pdb
3SS6

Yes

GBAA4240

47529533

acetyl-CoA acetyltransferase [Bacillus a...

391

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3SS6

99.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Other

IDP04292
(show subtarget assignments)

1

cloned

No

YPO0812

218927992

general secretion pathway protein H [Yer...

180

conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP04658
(show subtarget assignments)

1

purified

No

FTT1736c

56708739

kdpD

two component sensor protein kdpD [Franc...

893

conserved gene;

Phase 4: April 2009

2R8R

11.4%

Francisella tularensis

IDP04644
(show subtarget assignments)

1

cloned

No

FTT0895

56707996

purN

phosphoribosylglycinamide formyltransfer...

191

conserved gene;

Phase 4: April 2009

1C2T

40.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04643
(show subtarget assignments)

1

in_pdb
3M84
3QTY

No

FTT0893

56707994

purM

phosphoribosylaminoimidazole synthetase ...

347

conserved gene;

Phase 4: April 2009

3M84

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04631
(show subtarget assignments)

1

cloned

No

CBU_1891

215919282

pilQ

type II and III secretion system family ...

353

conserved gene;

Phase 4: April 2009

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP04312
(show subtarget assignments)

1

cloned

No

FTT0204

56707368

purA

adenylosuccinate synthetase [Francisella...

428

conserved gene;

Phase 4: April 2009

1ADE

45.9%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90226
(show subtarget assignments)

1

selected

No

VC2428

9657003

conserved hypothetical protein [Vibrio c...

246

Conserved gene clusters with virulence associated genes. Conserved Protein; Pred...

January 2009

2OEZ

74.8%

Vibrio cholerae

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01129
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5296

30259774

ferritin

168

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

48.2%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00588
(show subtarget assignments)

1

purified

No

YPO2077

16122316

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

87.8%

Yersinia pestis

Cellular processes

Cell division

IDP01126
(show subtarget assignments)

1

cloned

No

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01124
(show subtarget assignments)

1

purified

No

BA_4938

33301353

UDP-N-acetylmuramate--L-alanine ligase (...

436

Conserved Gene / Pathway

Phase 2: March 2008

1J6U

30.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01123
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4267

30258769

ptsI

phosphoenolpyruvate-protein phosphotrans...

570

Conserved Gene / Pathway

Phase 2: March 2008

2HRO

65.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01122
(show subtarget assignments)

1

soluble

No

BA_4045

30258552

ftsZ

cell division protein FtsZ

386

Conserved Gene / Pathway

Phase 2: March 2008

2VAM

78.1%

Bacillus anthracis

Cellular processes

Cell division

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01120
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1194

30254907

oligopeptide ABC transporter, ATP-bindin...

347

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01119
(show subtarget assignments)

1

purified

No

BA_0344

30253882

ahpF

alkyl hydroperoxide reductase, F subunit...

508

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

55.7%

Bacillus anthracis

Cellular processes

Detoxification

IDP01118
(show subtarget assignments)

1

crystallized

No

BA_4030

81837831

Bifunctional protein pyrR [Includes: Pyr...

180

Conserved Gene / Pathway

Phase 2: March 2008

1A3C

73.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01117
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3754

33301235

LexA repressor

206

Conserved Gene / Pathway

Phase 2: March 2008

3K2Z

38.3%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP00582
(show subtarget assignments)

1

in_pdb
3GSE

Yes

YPO2528

16122747

menF

menaquinone-specific isochorismate synth...

455

Conserved Gene / Pathway

Phase 2: March 2008

3GSE

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01114
(show subtarget assignments)

1

soluble

No

BA_4901

38502945

Septation ring formation regulator ezrA

570

Conserved Gene / Pathway

Phase 2: March 2008

Bacillus anthracis

Cellular processes

Cell division

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01112
(show subtarget assignments)

1

in_pdb
3G48

No

BA_2064

30256713

csaA

chaperone CsaA

109

Conserved Gene / Pathway

Phase 2: March 2008

3G48

99.1%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01111
(show subtarget assignments)

1

cloned

No

BA_1135

49035527

Major cold shock protein cspA

67

Conserved Gene / Pathway

Phase 2: March 2008

1CSP

73.1%

Bacillus anthracis

Cellular processes

Adaptations to atypical conditions

IDP00580
(show subtarget assignments)

1

purified

No

YPO0059

16120412

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

403

Conserved Gene / Pathway

Phase 2: March 2008

1FC4

82.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01110
(show subtarget assignments)

1

in_pdb
3RYK

Yes

BA_1229

30255178

rfbC

dTDP-4-dehydrorhamnose 3,5-epimerase

181

Conserved Gene / Pathway

Phase 2: March 2008

3RYK

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00579
(show subtarget assignments)

1

cloned

No

YPO1122

16121422

tolR

colicin uptake protein TolR

142

Conserved Gene / Pathway

Phase 2: March 2008

2JWK

23.9%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01108
(show subtarget assignments)

1

in_pdb

No

BA_3860

30258377

copper-ion-binding protein

68

Conserved Gene / Pathway

Phase 2: March 2008

2L3M

100%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01107
(show subtarget assignments)

1

soluble

No

BA_2250

30256894

heat shock protein, Hsp20 family

153

Conserved Gene / Pathway

Phase 2: March 2008

3AAB

24.2%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01106
(show subtarget assignments)

1

soluble

No

BA_1846

30256116

msrA-1

peptide methionine sulfoxide reductase

178

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

36%

Bacillus anthracis

Protein fate

Protein modification and repair

IDP01104
(show subtarget assignments)

1

soluble

No

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01520
(show subtarget assignments)

1

expressed

No

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01100
(show subtarget assignments)

1

in_pdb
3K1S

No

BA_5442

30259910

celC-2

PTS system, cellobiose-specific IIA comp...

107

Conserved Gene / Pathway

Phase 2: March 2008

3K1S

99.1%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01091
(show subtarget assignments)

1

in_crystallization_trials

No

STM4578

16767819

serB

phosphoserine phosphatase

322

Conserved Gene / Pathway

Phase 2: March 2008

3N28

47.2%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP01090
(show subtarget assignments)

0

work_stopped

No

STM4567

16767808

deoC

deoxyribose-phosphate aldolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1JCL

94.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP01089
(show subtarget assignments)

1

soluble

No

STM4533

16767777

tsr

methyl-accepting chemotaxis protein I

553

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

49.5%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01087
(show subtarget assignments)

1

cloned

No

STM4465

16767710

ornithine carbamoyltransferase

334

Conserved Gene / Pathway

Phase 2: March 2008

3UPD

75.7%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP01086
(show subtarget assignments)

1

in_crystallization_trials

No

STM4404

16767650

cysQ

PAPS (adenosine 3'-phosphate 5'-phosphos...

246

Conserved Gene / Pathway

Phase 2: March 2008

3B8B

48.1%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP01085
(show subtarget assignments)

1

in_crystallization_trials

No

STM4397

161353572

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans...

206

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP01084
(show subtarget assignments)

1

purified

No

STM4377

161353573

aidB

putative acyl-CoA dehydrogenase

546

Conserved Gene / Pathway

Phase 2: March 2008

3DJL

84.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01083
(show subtarget assignments)

1

in_pdb
3OPK

No

STM4324

16767573

cutA

divalent-cation tolerance protein CutA

115

Conserved Gene / Pathway

Phase 2: March 2008

3OPK

100%

Salmonella enterica

Cellular processes

Detoxification

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP01081
(show subtarget assignments)

1

soluble

No

STM4267

16767517

putative glutathione S-transferase

222

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

28.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01080
(show subtarget assignments)

0

work_stopped

No

STM4220

16767470

lysC

aspartate kinase III

449

Conserved Gene / Pathway

Phase 2: March 2008

2J0W

93.1%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP00568
(show subtarget assignments)

0

work_stopped

No

YPO0106

16120453

hslV

ATP-dependent protease peptidase subunit...

174

Conserved Gene / Pathway

Phase 2: March 2008

1E94

90.2%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00731
(show subtarget assignments)

1

purified

No

SACOL2462

57286457

ABC transporter, ATP-binding protein

220

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

35.5%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01518
(show subtarget assignments)

1

purified

No

VC1512

15641521

formate dehydrogenase, iron-sulfur subun...

202

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

29%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP01077
(show subtarget assignments)

0

work_stopped

No

STM4122

161353577

argB

acetylglutamate kinase

257

Conserved Gene / Pathway

Phase 2: March 2008

1GS5

94.2%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

Targets