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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 13 of 60, showing 100 records out of 5973 total, starting on record 1201
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP01977
(
show subtarget assignments
)
1
cloned
No
Cj1444c
15792762
kpsD
capsular polysaccharide ABC transporter,...
552
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
Campylobacter jejuni
Cellular processes
Other
IDP01770
(
show subtarget assignments
)
1
expressed
No
Cj1447c
15792764
kpsT
capsular polysaccharide ABC transporter,...
220
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
2BBS
26.8%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP01773
(
show subtarget assignments
)
1
soluble
No
Cj1466
15792783
flgK
flagellar hook-associated protein FlgK [...
608
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
2D4Y
18.7%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP90660
(
show subtarget assignments
)
8
cloned
No
Cj1476c
15792791
pyruvate ferredoxin/flavodoxin oxidoredu...
1186
Predicted Essential
Community Requests
1B0P
53.7%
Campylobacter jejuni
IDP02586
(
show subtarget assignments
)
1
cloned
No
Cj1478c
15792793
cadF
fibronectin-binding protein [Campylobact...
319
Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...
Phase 3: June 2008
3NB3
24.5%
Campylobacter jejuni
Cell envelope
Other
IDP90859
(
show subtarget assignments
)
8
expressed
No
Cj1494c
15792809
carA
carbamoyl phosphate synthase small subun...
372
Predicted Essential
Community Requests
1BXR
40.3%
Campylobacter jejuni
IDP90608
(
show subtarget assignments
)
8
in_pdb
3R7T
No
Cj1498c
15792813
purA
adenylosuccinate synthetase [Campylobact...
416
Predicted Essential
Community Requests
3R7T
100%
Campylobacter jejuni
IDP90875
(
show subtarget assignments
)
8
purified
No
Cj1529c
15792837
purM
phosphoribosylaminoimidazole synthetase ...
329
Predicted Essential
Community Requests
3P4E
53.8%
Campylobacter jejuni
IDP00325
(
show subtarget assignments
)
1
crystallized
No
Cj1530
15792838
coaE
dephospho-CoA kinase
201
Drug Target Function
Phase 2: March 2008
2IF2
32.8%
Campylobacter jejuni
Unclassified
Unclassified
IDP90698
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj1531
15792839
dapF
diaminopimelate epimerase [Campylobacter...
249
Predicted Essential
Community Requests
3EJX
30.2%
Campylobacter jejuni
IDP01964
(
show subtarget assignments
)
1
in_pdb
3KWO
No
Cj1534c
15792842
bacterioferritin [Campylobacter jejuni s...
149
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
3KWO
100%
Campylobacter jejuni
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP90667
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj1535c
15792843
pgi
glucose-6-phosphate isomerase [Campyloba...
406
Predicted Essential
Community Requests
1ZZG
30.3%
Campylobacter jejuni
IDP90765
(
show subtarget assignments
)
8
purified
No
Cj1536c
15792844
galU
UTP-glucose-1-phosphate uridylyltransfer...
274
Predicted Essential
Community Requests
3JUJ
60.6%
Campylobacter jejuni
IDP90877
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj1548c
15792856
oxidoreductase, zinc-binding dehydrogena...
358
Predicted Essential
Community Requests
3TWO
63.7%
Campylobacter jejuni
IDP02495
(
show subtarget assignments
)
1
cloned
No
Cj1565c
15792870
pflA
paralyzed flagella protein PflA [Campylo...
788
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Unclassified
Unclassified
IDP90550
(
show subtarget assignments
)
8
purified
No
Cj1594
15792899
rpsD
30S ribosomal protein S4 [Campylobacter ...
208
Predicted Essential
Community Requests
1VS5
50.7%
Campylobacter jejuni
IDP90688
(
show subtarget assignments
)
8
crystallized
No
Cj1595
15792900
rpoA
DNA-directed RNA polymerase subunit alph...
337
Predicted Essential
Community Requests
3IYD
31.5%
Campylobacter jejuni
IDP90801
(
show subtarget assignments
)
8
soluble
No
Cj1597
15792902
hisG
ATP phosphoribosyltransferase [Campyloba...
299
Predicted Essential
Community Requests
1H3D
66.2%
Campylobacter jejuni
IDP90730
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj1598
15792903
hisD
histidinol dehydrogenase [Campylobacter ...
428
Predicted Essential
Community Requests
1K75
59.8%
Campylobacter jejuni
IDP90693
(
show subtarget assignments
)
8
purified
No
Cj1599
15792904
hisB
imidazole glycerol-phosphate dehydratase...
352
Predicted Essential
Community Requests
1RHY
25.6%
Campylobacter jejuni
IDP90547
(
show subtarget assignments
)
8
crystallized
No
Cj1601
15792906
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosy...
243
Predicted Essential
Community Requests
2X30
33.7%
Campylobacter jejuni
IDP00326
(
show subtarget assignments
)
0
work_stopped
No
Cj1607
15792912
ispDF
bifunctional 2-C-methyl-D-erythritol 4-p...
371
Drug Target Function
Phase 2: March 2008
1W55
100%
Campylobacter jejuni
Amino acid biosynthesis
Histidine family
IDP01789
(
show subtarget assignments
)
0
work_stopped
No
Cj1613c
15792918
hypothetical protein Cj1613c [Campylobac...
251
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
3SWJ
98.8%
Campylobacter jejuni
Biosynthesis of cofactors, prosthetic groups, and carriers
Other
IDP02626
(
show subtarget assignments
)
1
cloned
No
Cj1614
15792919
chuA
TonB-dependent heme receptor [Campylobac...
709
Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate
Phase 3: June 2008
3FHH
23.3%
Campylobacter jejuni
Regulatory functions
Other
IDP01781
(
show subtarget assignments
)
1
expressed
No
Cj1616
15792921
chuC
hemin ABC transporter, ATP-binding prote...
258
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
1F3O
31.4%
Campylobacter jejuni
Fatty acid and phospholipid metabolism
Biosynthesis
IDP02158
(
show subtarget assignments
)
1
cloned
No
Cj1617
15792922
chuD
putative haemin uptake system periplasmi...
268
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
3GFV
27%
Campylobacter jejuni
Protein synthesis
Ribosomal proteins: synthesis and modification
IDP90745
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj1622
15792927
ribD
putative riboflavin-specific deaminase [...
336
Predicted Essential
Community Requests
2HXV
28%
Campylobacter jejuni
IDP00327
(
show subtarget assignments
)
0
work_stopped
No
Cj1634c
15792939
aroC
chorismate synthase
362
Drug Target Function
Phase 2: March 2008
1SQ1
100%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP90862
(
show subtarget assignments
)
8
in_pdb
3O2R
3N3W
Yes
Cj1635c
15792940
rnc
ribonuclease III [Campylobacter jejuni s...
224
Predicted Essential
Community Requests
3N3W
100%
Campylobacter jejuni
IDP90712
(
show subtarget assignments
)
8
cloned
No
Cj1638
15792943
dnaG
DNA primase [Campylobacter jejuni subsp....
605
Predicted Essential
Community Requests
2AU3
18.3%
Campylobacter jejuni
IDP90749
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj1641
15792946
murE
UDP-N-acetylmuramoylalanyl-D-glutamate--...
427
Predicted Essential
Community Requests
2WTZ
34.4%
Campylobacter jejuni
IDP90564
(
show subtarget assignments
)
8
in_pdb
3L84
3M34
3M6L
3M7I
No
Cj1645
15792950
tkt
transketolase [Campylobacter jejuni subs...
632
Predicted Essential
Community Requests
3L84
100%
Campylobacter jejuni
IDP00328
(
show subtarget assignments
)
1
in_pdb
3UHP
3UHF
3UHO
No
Cj1652c
15792957
murI
glutamate racemase
250
Drug Target Function
Phase 2: March 2008
2JFX
53.7%
Campylobacter jejuni
Energy metabolism
Pentose phosphate pathway
IDP01836
(
show subtarget assignments
)
1
cloned
No
Cj1659
15792963
p19
hypothetical protein Cj1659 [Campylobact...
179
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
3LZL
88.3%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90735
(
show subtarget assignments
)
8
in_pdb
3QN3
Yes
Cj1672c
15792976
eno
phosphopyruvate hydratase [Campylobacter...
414
Predicted Essential
Community Requests
3QN3
100%
Campylobacter jejuni
IDP90510
(
show subtarget assignments
)
8
soluble
No
Cj1676
15792980
murB
UDP-N-acetylenolpyruvoylglucosamine redu...
258
Predicted Essential
Community Requests
3TX1
32.9%
Campylobacter jejuni
IDP02654
(
show subtarget assignments
)
1
cloned
No
Cj1682c
15792986
gltA
citrate synthase [Campylobacter jejuni s...
422
Possible Vaccine Candidate; Predicted Essential-Modeling
Phase 3: June 2008
2H12
50.2%
Campylobacter jejuni
Cellular processes
Chemotaxis and motility
IDP90582
(
show subtarget assignments
)
8
soluble
No
Cj1686c
15792989
topA
DNA topoisomerase I [Campylobacter jejun...
700
Predicted Essential
Community Requests
2GAI
38.6%
Campylobacter jejuni
IDP90619
(
show subtarget assignments
)
8
soluble
No
Cj1701c
15793004
rpsC
30S ribosomal protein S3 [Campylobacter ...
233
Predicted Essential
Community Requests
1VS5
56.7%
Campylobacter jejuni
IDP90790
(
show subtarget assignments
)
8
in_pdb
3Q3W
Yes
Cj1716c
15793019
leuD
isopropylmalate isomerase small subunit ...
200
Predicted Essential
Community Requests
3Q3W
100%
Campylobacter jejuni
IDP01791
(
show subtarget assignments
)
1
in_pdb
3UDU
3UDO
Yes
Cj1718c
15793021
leuB
3-isopropylmalate dehydrogenase [Campylo...
358
Possible Vaccine Candidate; Predicted Essential-Modeling
Phase 3: June 2008
3UDO
99.7%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP90724
(
show subtarget assignments
)
8
expressed
No
Cj1719c
15793022
leuA
2-isopropylmalate synthase [Campylobacte...
511
Predicted Essential
Community Requests
3RMJ
37.6%
Campylobacter jejuni
IDP00329
(
show subtarget assignments
)
1
cloned
No
Cj1724c
15793027
7-cyano-7-deazaguanine reductase
127
Drug Target Function
Phase 2: March 2008
Campylobacter jejuni
Amino acid biosynthesis
Pyruvate family
IDP90854
(
show subtarget assignments
)
8
crystallized
No
Cj1727c
15793030
metY
putative O-acetylhomoserine (thiol)-lyas...
423
Predicted Essential
Community Requests
2CTZ
40.9%
Campylobacter jejuni
IDP02627
(
show subtarget assignments
)
1
soluble
No
Cj1729c
15793032
flgE
flagellar hook protein FlgE [Campylobact...
865
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
3A69
13.4%
Campylobacter jejuni
Cell envelope
Other
IDP91045
(
show subtarget assignments
)
8
cloned
No
ECH0010
15799700
hypothetical protein Z0021 [Escherichia ...
108
virulence/pathogenesis /
Hypothetical protein Z0021 is involved in regulation of swimming motility in E. ...
Community Requests
Escherichia coli
IDP04520
(
show subtarget assignments
)
1
purified
No
Z0985
15800520
hypothetical protein Z0985 [Escherichia ...
326
Effector protein
Phase 4: April 2009
Escherichia coli
IDP04116
(
show subtarget assignments
)
1
expressed
No
Z5122
15804232
sepZ
hypothetical protein Z5122 [Escherichia ...
99
Effector protein
Phase 4: April 2009
Escherichia coli
IDP04209
(
show subtarget assignments
)
1
soluble
No
Z5142
15804250
hypothetical protein Z5142 [Escherichia ...
398
Effector protein
Phase 4: April 2009
3PCR
89.7%
Escherichia coli
IDP90250
(
show subtarget assignments
)
8
expressed
No
Z5515
15804553
argE
acetylornithine deacetylase [Escherichia...
383
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3IC1
26.9%
Escherichia coli
IDP91591
(
show subtarget assignments
)
8
selected
No
Atu2521
15889786
lpiA
protein regulated by acid pH [Agrobacter...
866
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Agrobacterium tumefaciens
IDP91854
(
show subtarget assignments
)
8
expressed
No
SP_0141
15900079
transcriptional regulator [Streptococcus...
287
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91761
(
show subtarget assignments
)
8
in_pdb
4EYS
4E94
No
SP_0182
15900119
MccC family protein [Streptococcus pneum...
343
drug resistance; innate immunity /
Streptococcus pneumoniae MccF-like (MccF homolog) - E.coli MccF confers immunity...
Community Requests
4E94
100%
Streptococcus pneumoniae
IDP91069
(
show subtarget assignments
)
8
cloned
No
SP_1357
15901211
ABC transporter, ATP-binding/permease pr...
596
drug resistance /
The proteins of interest on the list are multi drug resistance transporters. Mu...
Community Requests
3QF4
37.1%
Streptococcus pneumoniae
IDP91845
(
show subtarget assignments
)
8
expressed
No
spr0960
15903004
mutR
putative positive transcriptional regula...
284
virulence/pathogenesis /
Rgg proteins are peptide-ligand-responsive transcription factors that control vi...
Community Requests
Streptococcus pneumoniae
IDP91221
(
show subtarget assignments
)
8
soluble
No
SAV1231
15924221
fabG
3-oxoacyl-(acyl-carrier protein) reducta...
246
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3OSU
100%
Staphylococcus aureus
IDP05774
(
show subtarget assignments
)
1
in_pdb
3OSU
No
SAV1231
15924221
fabG
3-oxoacyl-(acyl-carrier protein) reducta...
246
potential drug target /
Potential drug target
Phase 5: 2010
3OSU
100%
Staphylococcus aureus
IDP91592
(
show subtarget assignments
)
8
soluble
No
SAV1360
15924350
fmtC
oxacillin resistance-related FmtC protei...
840
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Staphylococcus aureus
IDP91874
(
show subtarget assignments
)
8
cloned
No
SA0006
15925711
gyrA
DNA gyrase subunit A [Staphylococcus aur...
889
drug target /
Achillion Pharmaceuticals is interested in obtaining crystal structural data by ...
Community Requests
2XCO
55.1%
Staphylococcus aureus
IDP90223
(
show subtarget assignments
)
1
expressed
No
SA1226
15926974
Asd
Aspartate semialdehyde dehydrogenase Asd...
329
This enzyme participates in glycine, serine and threonine metabolism and lysine ...
January 2009
2YV3
43.4%
Staphylococcus aureus
IDP91784
(
show subtarget assignments
)
8
soluble
No
SA1480
15927234
ermA
rRNA methylase Erm(A) [Staphylococcus au...
243
drug resistance /
rRNA methylase (macrolide-lincosamide-streptogramin B resistance protein)
Community Requests
1QAM
56.8%
Staphylococcus aureus
IDP90242
(
show subtarget assignments
)
8
expressed
No
SA1814
15927582
succinyl-diaminopimelate desuccinylase [...
407
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3TX8
25.5%
Staphylococcus aureus
IDP91593
(
show subtarget assignments
)
8
expressed
No
BSU08430
16077910
yfiX
hypothetical protein BSU08430 [Bacillus ...
606
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Bacillus subtilis
IDP91199
(
show subtarget assignments
)
1
cloned
No
BSU40540
16081106
yybR
putative transcriptional regulator [Baci...
125
other biological interest /
YybR belongs to the MarR/DUF24 family of transcriptional regulators that are hig...
Community Requests
4A5M
100%
Bacillus subtilis
IDP01823
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPPCP1.05c
16082684
pst
pesticin [Yersinia pestis CO92]
357
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...
Phase 3: June 2008
4AQN
100%
Yersinia pestis
Regulatory functions
Other
IDP00432
(
show subtarget assignments
)
1
soluble
No
YPCD1.12c
16082702
sopB
putative plasmid-partitioning control pr...
320
Virulence Associated Factor
Phase 2: March 2008
3MKY
22.5%
Yersinia pestis
Cellular processes
Cell division
IDP00451
(
show subtarget assignments
)
1
expressed
No
YPCD1.20
16082709
yopT
Yop targeted effector
322
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Surface structures
IDP04697
(
show subtarget assignments
)
1
soluble
No
YPCD1.29c
16082717
yopB
secreted effector protein [Yersinia pest...
401
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP04289
(
show subtarget assignments
)
1
expressed
No
YPCD1.35c
16082723
yscY
hypothetical protein YPCD1.35c [Yersinia...
114
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04025
(
show subtarget assignments
)
1
expressed
No
YPCD1.36c
16082724
yscX
hypothetical protein YPCD1.36c [Yersinia...
122
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP00450
(
show subtarget assignments
)
1
cloned
No
YPCD1.40
16082728
yscN
type III secretion system ATPase
439
Virulence Associated Factor
Phase 2: March 2008
2DPY
42.8%
Yersinia pestis
Energy metabolism
ATP-proton motive force interconversion
IDP04100
(
show subtarget assignments
)
1
cloned
No
YPCD1.45
16082733
yscS
needle complex export protein [Yersinia ...
88
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP04698
(
show subtarget assignments
)
1
cloned
No
YPCD1.46
16082734
yscT
needle complex export protein [Yersinia ...
261
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP00404
(
show subtarget assignments
)
1
soluble
No
YPCD1.48
16082736
virG
needle complex outer membrane lipoprotei...
131
Virulence Associated Factor
Phase 2: March 2008
2YJL
23.7%
Yersinia pestis
Cellular processes
Adaptations to atypical conditions
IDP04274
(
show subtarget assignments
)
1
cloned
No
YPCD1.49
16082737
virF
transcriptional regulator [Yersinia pest...
271
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
3OIO
11.8%
Yersinia pestis
Regulatory functions
Other
IDP04434
(
show subtarget assignments
)
1
cloned
No
YPCD1.52
16082740
yscC
outer membrane secretin precursor [Yersi...
607
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2Y9K
6.9%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP04699
(
show subtarget assignments
)
1
expressed
No
YPCD1.53
16082741
yscD
virulence protein [Yersinia pestis CO92]...
419
virulence factor; conserved gene;
Phase 4: April 2009
4A0E
28.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP00413
(
show subtarget assignments
)
1
soluble
No
YPCD1.60
16082748
yscK
type III secretion apparatus component
209
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00447
(
show subtarget assignments
)
1
cloned
No
YPCD1.71c
16082759
yopJ
targeted effector protein
288
Virulence Associated Factor
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP04046
(
show subtarget assignments
)
1
cloned
No
YPCD1.78c
16082765
tap
repA translation protein [Yersinia pesti...
24
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP00517
(
show subtarget assignments
)
1
soluble
No
YPMT1.71
16082863
hypothetical protein YPMT1.71
328
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP00525
(
show subtarget assignments
)
1
cloned
No
YPMT1.83
16082875
caf1A
putative F1 capsule anchoring protein
833
Virulence Associated Factor
Phase 2: March 2008
3RFZ
35.3%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00113
(
show subtarget assignments
)
0
work_stopped
No
NT01SAA0015
16119212
blaI
PENICILLINASE REPRESSOR
126
Virulence
Phase 1: October 2007
1SD4
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP02000
(
show subtarget assignments
)
1
cloned
No
YPO0008
16120361
rbsK
ribokinase [Yersinia pestis CO92]
308
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...
Phase 3: June 2008
1GQT
70.5%
Yersinia pestis
Energy metabolism
Pentose phosphate pathway
IDP02032
(
show subtarget assignments
)
1
expressed
No
YPO0013
16120366
mobA
molybdopterin-guanine dinucleotide biosy...
213
Involved in virulence; Drug target functions
Phase 3: June 2008
1E5K
39.9%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Molybdopterin
IDP02120
(
show subtarget assignments
)
1
expressed
No
YPO0027
16120380
phosphatase [Yersinia pestis CO92]
196
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
2B0C
66.8%
Yersinia pestis
Unknown function
General
IDP90925
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO0048
16120401
dfp
phosphopantothenoylcysteine synthase/dec...
405
Predicted Essential
Community Requests
1U7U
40%
Yersinia pestis
IDP90549
(
show subtarget assignments
)
8
in_pdb
3L92
3L93
No
YPO0053
16120406
coaD
phosphopantetheine adenylyltransferase [...
159
Predicted Essential
Community Requests
3L92
100%
Yersinia pestis
IDP02133
(
show subtarget assignments
)
1
expressed
No
YPO0054
16120407
kdtX
lipopolysaccharide core biosynthesis gly...
260
Drug target motif; Involved in virulence; Drug target functions
Phase 3: June 2008
3E25
11.5%
Yersinia pestis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90803
(
show subtarget assignments
)
8
selected
No
YPO0055
16120408
kdtA
3-deoxy-D-manno-octulosonic-acid transfe...
425
Predicted Essential
Community Requests
2XCI
25.2%
Yersinia pestis
IDP90822
(
show subtarget assignments
)
8
purified
No
YPO0056
16120409
rfaC
ADP-heptose:LPS heptosyl transferase I [...
321
Predicted Essential
Community Requests
2GT1
67.9%
Yersinia pestis
IDP90918
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO0057
16120410
rfaF
ADP-heptose:LPS heptosyltransferase II [...
354
Predicted Essential
Community Requests
1PSW
72.3%
Yersinia pestis
IDP90552
(
show subtarget assignments
)
8
soluble
No
YPO0058
16120411
rfaD
ADP-L-glycero-D-mannoheptose-6-epimerase...
310
Predicted Essential
Community Requests
1EQ2
82.3%
Yersinia pestis
IDP00580
(
show subtarget assignments
)
1
purified
No
YPO0059
16120412
kbl
2-amino-3-ketobutyrate coenzyme A ligase...
403
Conserved Gene / Pathway
Phase 2: March 2008
1FC4
82.9%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP00538
(
show subtarget assignments
)
1
in_pdb
3GVD
No
YPO0070
16120421
cysE
serine acetyltransferase
273
Drug Target Function
Phase 2: March 2008
3GVD
100%
Yersinia pestis
Amino acid biosynthesis
Serine family
IDP90718
(
show subtarget assignments
)
8
in_pdb
3N4J
3N4K
No
YPO0071
16120422
putative methyltransferase [Yersinia pes...
162
Predicted Essential
Community Requests
3N4J
100%
Yersinia pestis
IDP02058
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0075
16120426
cpxP
periplasmic stress adaptor protein CpxP ...
162
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3ITF
41.4%
Yersinia pestis
Transport and binding proteins
Amino acids, peptides and amines
IDP00494
(
show subtarget assignments
)
1
soluble
No
YPO0099
16120446
hypothetical protein YPO0099
411
Drug Target Function
Phase 2: March 2008
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP02759
(
show subtarget assignments
)
1
cloned
No
YPO0102
16120449
hypothetical protein YPO0102 [Yersinia p...
194
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
Yersinia pestis
Cell envelope
Other
IDP90887
(
show subtarget assignments
)
8
cloned
No
YPO0104
16120451
menA
1,4-dihydroxy-2-naphthoate octaprenyltra...
305
Predicted Essential
Community Requests
Yersinia pestis
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