Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01350 (show subtarget assignments)	1	in_pdb 3EEV	No	VCA0300	15601065		chloramphenicol acetyltransferase	209	Drug Target Function	Phase 2: March 2008	3EEV	100%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01351 (show subtarget assignments)	1	cloned	No	VCA0387	15601150		toxin resistance protein	169	Conserved Gene / Pathway	Phase 2: March 2008	1YVO	31.4%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01352 (show subtarget assignments)	1	soluble	No	VCA0447	15601210		haemagglutinin associated protein	230	Conserved Gene / Pathway	Phase 2: March 2008	1G60	29.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01353 (show subtarget assignments)	1	expressed	No	VCA0646	15601404		conserved hypothetical protein/hemolysin...	605	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01354 (show subtarget assignments)	1	cloned	No	VC0003	15640035	trmE	tRNA modification GTPase TrmE	464	Conserved Gene / Pathway	Phase 2: March 2008	3GEH	37.9%	Vibrio cholerae	Cellular processes	Detoxification

IDP01355 (show subtarget assignments)	1	soluble	No	VC0008	15640040		amino acid ABC transporter, ATP-binding ...	245	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	51.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01356 (show subtarget assignments)	1	soluble	No	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01357 (show subtarget assignments)	1	in_pdb 3FWX	Yes	VC0046	15640078	def	peptide deformylase	169	Conserved Gene / Pathway	Phase 2: March 2008	3FWX	100%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP01358 (show subtarget assignments)	1	in_pdb 3QZ3	Yes	VC0078	15640110		ferritin	181	Conserved Gene / Pathway	Phase 2: March 2008	3QZ3	100%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01359 (show subtarget assignments)	1	soluble	No	VC0147	15640178		cell division protein FtsY	391	Conserved Gene / Pathway	Phase 2: March 2008	2YHS	67.5%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP01360 (show subtarget assignments)	1	purified	No	VC0148	15640179		cell division ATP-binding protein FtsE	233	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	35.6%	Vibrio cholerae	Cellular processes	Cell division

IDP01361 (show subtarget assignments)	1	expressed	No	VC0157	15640187		alkaline serine protease	535	Drug Target Function	Phase 2: March 2008	1S2N	35.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01362 (show subtarget assignments)	1	purified	No	VC0158	15640188		glutamate racemase	265	Drug Target Function	Phase 2: March 2008	2JFN	49.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01363 (show subtarget assignments)	1	soluble	No	VC0171	15640201		peptide ABC transporter, periplasmic pep...	542	Conserved Gene / Pathway	Phase 2: March 2008	1DPE	27.1%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01364 (show subtarget assignments)	1	expressed	No	VC0200	15640230		iron(III) compound receptor	718	Conserved Gene / Pathway	Phase 2: March 2008	3QLB	33.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01365 (show subtarget assignments)	1	purified	No	VC0201	15640231		iron(III) ABC transporter, ATP-binding p...	285	Conserved Gene / Pathway	Phase 2: March 2008	1JJ7	28.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01366 (show subtarget assignments)	1	soluble	No	VC0202	15640232		iron(III) ABC transporter, periplasmic i...	319	Conserved Gene / Pathway	Phase 2: March 2008	1EFD	25.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01367 (show subtarget assignments)	1	purified	No	VC0224	15640254		lipopolysaccharide biosynthesis glycosyl...	259	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01368 (show subtarget assignments)	1	soluble	No	VC0238	15640268		transferase, hexapeptide repeat family	188	Drug Target Function	Phase 2: March 2008	3JQY	38.3%	Vibrio cholerae	Central intermediary metabolism	Other

IDP01369 (show subtarget assignments)	1	in_crystallization_trials	No	VC0244	15640274		perosamine synthase	367	Conserved Gene / Pathway	Phase 2: March 2008	3BN1	41.7%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01370 (show subtarget assignments)	1	purified	No	VC0247	15640277		lipopolysaccharide/O-antigen transport p...	271	Conserved Gene / Pathway	Phase 2: March 2008	1OXS	25.8%	Vibrio cholerae	Transport and binding proteins	Other

IDP01371 (show subtarget assignments)	1	in_crystallization_trials	No	VC0250	15640280		iron-containing alcohol dehydrogenase fa...	374	Conserved Gene / Pathway	Phase 2: March 2008	3OWO	28.3%	Vibrio cholerae	Energy metabolism	Fermentation

IDP01372 (show subtarget assignments)	1	in_pdb 3I99	No	VC0318	15640345	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	357	Drug Target Function	Phase 2: March 2008	3I99	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01373 (show subtarget assignments)	1	soluble	No	VC0335	15640362		NlpD-related protein	382	Drug Target Function	Phase 2: March 2008	3SLU	13.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01374 (show subtarget assignments)	1	purified	No	VC0344	15640371		N-acetylmuramoyl-L-alanine amidase	581	Conserved Gene / Pathway	Phase 2: March 2008	3NE8	13.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01375 (show subtarget assignments)	1	in_crystallization_trials	No	VC0372	15640399	alr	alanine racemase	375	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	57.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01376 (show subtarget assignments)	1	soluble	No	VC0400	15640427		MSHA biogenesis protein MshJ	216	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01377 (show subtarget assignments)	1	cloned	No	VC0409	15640436		MSHA pilin protein MshA	178	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01378 (show subtarget assignments)	1	cloned	No	VC0410	15640437		MSHA pilin protein MshC	162	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01379 (show subtarget assignments)	1	purified	No	VC0474	15640501		iron-regulated virulence regulatory prot...	298	Conserved Gene / Pathway	Phase 2: March 2008	3SZP	27.2%	Vibrio cholerae	Regulatory functions	Other

IDP01145 (show subtarget assignments)	1	expressed	No	BA_0188	30253695		oligopeptide ABC transporter, ATP-bindin...	257	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	34.6%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01381 (show subtarget assignments)	1	purified	No	VC0529	15640551	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	158	Drug Target Function	Phase 2: March 2008	1GX1	74.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP01383 (show subtarget assignments)	1	in_crystallization_trials	No	VC0538	15640560		thiosulfate ABC transporter, periplasmic...	333	Conserved Gene / Pathway	Phase 2: March 2008	1SBP	42.3%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01384 (show subtarget assignments)	1	purified	No	VC0554	15640576		protease, insulinase family/protease, in...	952	Drug Target Function	Phase 2: March 2008	1Q2L	19.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01385 (show subtarget assignments)	1	cloned	No	VC0560	15640582		signal recognition particle protein	461	Drug Target Function	Phase 2: March 2008	2XXA	73.1%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP00597 (show subtarget assignments)	1	purified	No	YPO3909	16124041	murI	glutamate racemase	287	Conserved Gene / Pathway	Phase 2: March 2008	2JFN	71.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01387 (show subtarget assignments)	1	cloned	No	VC0566	15640588		protease DO	456	Drug Target Function	Phase 2: March 2008	2ZLE	57.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01388 (show subtarget assignments)	1	soluble	No	VC0608	15640628		iron(III) ABC transporter, periplasmic i...	352	Conserved Gene / Pathway	Phase 2: March 2008	1Q35	55.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01389 (show subtarget assignments)	1	purified	No	VC0610	15640630		iron(III) ABC transporter, ATP-binding p...	343	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	36.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01390 (show subtarget assignments)	1	purified	No	VC0617	15640637		peptide ABC transporter, ATP-binding pro...	327	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	24.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01391 (show subtarget assignments)	1	cloned	No	VC0633	15640653		outer membrane protein OmpU	350	Conserved Gene / Pathway	Phase 2: March 2008	3HW9	27.3%	Vibrio cholerae	Cell envelope	Other

IDP01392 (show subtarget assignments)	1	purified	No	VC0648	15640668		lipoprotein NlpI	303	Conserved Gene / Pathway	Phase 2: March 2008	1XNF	44.2%	Vibrio cholerae	Cell envelope	Other

IDP01393 (show subtarget assignments)	1	in_crystallization_trials	No	VC0684	15640703		peptidyl-prolyl cis-trans isomerase, FKB...	144	Conserved Gene / Pathway	Phase 2: March 2008	2K8I	33.3%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01394 (show subtarget assignments)	1	soluble	No	VC0700	15640719		soluble lytic murein transglycosylase	648	Drug Target Function	Phase 2: March 2008	1QSA	33.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01395 (show subtarget assignments)	1	purified	No	VC0704	15640723		spermidine/putrescine ABC transporter, p...	359	Conserved Gene / Pathway	Phase 2: March 2008	3TTK	27.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01144 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5153	30259639		phosphoglucomutase/phosphomannomutase fa...	574	Drug Target Function	Phase 2: March 2008	2FUV	26.3%	Bacillus anthracis	Energy metabolism	Sugars

IDP01397 (show subtarget assignments)	1	purified	No	VC0755	161582019		aminopeptidase B	429	Drug Target Function	Phase 2: March 2008	3H8E	32.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01398 (show subtarget assignments)	1	cloned	No	VC0762	15640781		outer membrane protein assembly complex ...	386	Conserved Gene / Pathway	Phase 2: March 2008	3P1L	43.3%	Vibrio cholerae	Cell envelope	Other

IDP01399 (show subtarget assignments)	1	in_crystallization_trials	No	VC0771	15640790		vibriobactin-specific isochorismatase	293	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	44.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01400 (show subtarget assignments)	1	expressed	No	VC0772	15640791		vibriobactin-specific 2,3-dihydroxybenzo...	543	Conserved Gene / Pathway	Phase 2: March 2008	1MD9	51.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01401 (show subtarget assignments)	1	purified	No	VC0773	15640792		vibriobactin-specific isochorismate synt...	395	Drug Target Function	Phase 2: March 2008	3OS6	44.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01402 (show subtarget assignments)	1	cloned	No	VC0843	15640860		tagE protein	302	Drug Target Function	Phase 2: March 2008	3SLU	18.9%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01403 (show subtarget assignments)	1	in_crystallization_trials	No	VC0854	15640870		heat shock protein GrpE	200	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	39.5%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01404 (show subtarget assignments)	1	purified	No	VC0856	15640872		dnaJ protein	381	Conserved Gene / Pathway	Phase 2: March 2008	3LZ8	31.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01405 (show subtarget assignments)	1	purified	No	VC0905	161582017	metQ	lipoprotein YaeC	269	Conserved Gene / Pathway	Phase 2: March 2008	3K2D	72.9%	Vibrio cholerae	Cell envelope	Other

IDP01406 (show subtarget assignments)	1	crystallized	No	VC0918	15640934	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	413	Conserved Gene / Pathway	Phase 2: March 2008	3OJL	45.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01407 (show subtarget assignments)	1	cloned	No	VC0947	15640963		D-alanyl-D-alanine carboxypeptidase	391	Drug Target Function	Phase 2: March 2008	1NZO	52.2%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01408 (show subtarget assignments)	1	purified	No	VC0965	15640981		phosphoenolpyruvate-protein phosphotrans...	573	Conserved Gene / Pathway	Phase 2: March 2008	2KX9	74.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01409 (show subtarget assignments)	1	purified	No	VC0972	15640988		porin, putative	349	Conserved Gene / Pathway	Phase 2: March 2008	1PHO	20.9%	Vibrio cholerae	Transport and binding proteins	Porins

IDP01410 (show subtarget assignments)	1	in_crystallization_trials	No	VC1091	15641104		oligopeptide ABC transporter, periplasmi...	543	Conserved Gene / Pathway	Phase 2: March 2008	2Z23	53.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01411 (show subtarget assignments)	1	purified	No	VC1095	15641108		oligopeptide ABC transporter, ATP-bindin...	336	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	28%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01412 (show subtarget assignments)	1	purified	No	VC1122	15641135		cyclopropane-fatty-acyl-phospholipid syn...	432	Drug Target Function	Phase 2: March 2008	1KPI	18.7%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01413 (show subtarget assignments)	1	purified	No	VC1174	15641187		anthranilate synthase component I	523	Drug Target Function	Phase 2: March 2008	1I1Q	59.3%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP01414 (show subtarget assignments)	1	purified	No	VC1359	15641371		amino acid ABC transporter, ATP-binding ...	251	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01415 (show subtarget assignments)	1	in_crystallization_trials	No	VC1363	15641375		siroheme synthase component enzyme	312	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	29.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01416 (show subtarget assignments)	1	soluble	No	VC1410	15641421		multidrug resistance protein VceA	406	Conserved Gene / Pathway	Phase 2: March 2008	4DK1	15.3%	Vibrio cholerae	Transport and binding proteins	Other

IDP01417 (show subtarget assignments)	1	soluble	No	VC1414	15641425		thermostable carboxypeptidase 1	524	Drug Target Function	Phase 2: March 2008	3DWC	44.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01418 (show subtarget assignments)	1	purified	No	VC1424	15641435		spermidine/putrescine ABC transporter, p...	345	Conserved Gene / Pathway	Phase 2: March 2008	1POT	61.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01419 (show subtarget assignments)	1	in_crystallization_trials	No	VC1425	15641436		spermidine/putrescine ABC transporter, p...	366	Conserved Gene / Pathway	Phase 2: March 2008	1POT	52.7%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01420 (show subtarget assignments)	1	cloned	No	VC1496	15641505		carboxy-terminal protease	665	Drug Target Function	Phase 2: March 2008	1FC6	16.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01421 (show subtarget assignments)	1	soluble	No	VC1544	15641552		tonB2 protein	206	Conserved Gene / Pathway	Phase 2: March 2008	2K9K	34%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01422 (show subtarget assignments)	1	expressed	No	VC1549	15641557		glycerol-3-phosphate ABC transporter, pe...	434	Conserved Gene / Pathway	Phase 2: March 2008	2HEU	20%	Vibrio cholerae	Transport and binding proteins	Other

IDP01423 (show subtarget assignments)	1	purified	No	VC1552	15641560	ugpC	glycerol-3-phosphate ABC transporter, AT...	393	Conserved Gene / Pathway	Phase 2: March 2008	2D62	45.5%	Vibrio cholerae	Transport and binding proteins	Other

IDP01424 (show subtarget assignments)	1	purified	No	VC1568	15641576		ABC transporter, ATP-binding protein	233	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	49.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01425 (show subtarget assignments)	1	expressed	No	VC1630	15641635		ABC transporter, ATP-binding protein	227	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	37%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01426 (show subtarget assignments)	1	expressed	No	VC1680	15641684		peptide ABC transporter, periplasmic pep...	540	Conserved Gene / Pathway	Phase 2: March 2008	1DPP	35%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01427 (show subtarget assignments)	1	purified	No	VC1684	15641688		peptide ABC transporter, ATP-binding pro...	262	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	33.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01428 (show subtarget assignments)	1	purified	No	VC1709	15641713		zinc protease, insulinase family	922	Drug Target Function	Phase 2: March 2008	3CWW	19%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01429 (show subtarget assignments)	1	in_crystallization_trials	No	VC1849	15641851		peptidyl-prolyl cis-trans isomerase B	164	Conserved Gene / Pathway	Phase 2: March 2008	1LOP	64%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01430 (show subtarget assignments)	1	in_crystallization_trials	No	VC1863	15641865		amino acid ABC transporter, periplasmic ...	260	Conserved Gene / Pathway	Phase 2: March 2008	1LAF	39.2%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01431 (show subtarget assignments)	1	purified	No	VC1864	15641866		amino acid ABC transporter, ATP-binding ...	256	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	62.9%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01432 (show subtarget assignments)	1	cloned	No	VC1918	15641920		peptidyl-prolyl cis-trans isomerse D	619	Drug Target Function	Phase 2: March 2008	1M5Y	16%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01433 (show subtarget assignments)	1	purified	No	VC1922	15641924	clpP	ATP-dependent Clp protease proteolytic s...	200	Drug Target Function	Phase 2: March 2008	1TYF	76%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01434 (show subtarget assignments)	1	purified	No	VC1944	15641946		PvcB protein	287	Conserved Gene / Pathway	Phase 2: March 2008	3EAT	46%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01435 (show subtarget assignments)	1	purified	No	VC1956	15641958		lytic murein transglycosylase, putative ...	323	Drug Target Function	Phase 2: March 2008	4ANR	32.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01143 (show subtarget assignments)	1	in_pdb 3R8Y	No	BA_4194	30258698		2,3,4,5-tetrahydropyridine-2-carboxylate...	240	Drug Target Function	Phase 2: March 2008	3R8Y	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01437 (show subtarget assignments)	1	purified	No	VC1983	15641985		peptidase, putative	615	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01438 (show subtarget assignments)	1	expressed	No	VC1993	15641995		2,4-dienoyl-CoA reductase	666	Drug Target Function	Phase 2: March 2008	1PS9	56.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP01439 (show subtarget assignments)	1	crystallized	No	VC2019	15642021		3-oxoacyl-(acyl carrier protein) synthas...	414	Drug Target Function	Phase 2: March 2008	1B3N	74.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00596 (show subtarget assignments)	1	purified	No	YPO0555	16120883	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	78.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01441 (show subtarget assignments)	1	in_crystallization_trials	No	VC2023	15642025		3-oxoacyl-(acyl carrier protein) synthas...	316	Drug Target Function	Phase 2: March 2008	1EBL	72.6%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01442 (show subtarget assignments)	1	expressed	No	VC2048	15642050		vacJ lipoprotein	254	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Other

IDP01443 (show subtarget assignments)	1	soluble	No	VC2061	15642061		ParA family protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1WCV	34.1%	Vibrio cholerae	Cellular processes	Cell division

IDP01444 (show subtarget assignments)	1	soluble	No	VC2081	15642081		zinc ABC transporter, periplasmic zinc-b...	297	Conserved Gene / Pathway	Phase 2: March 2008	2OGW	44.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01445 (show subtarget assignments)	1	soluble	No	VC2088	15642088	sdhB	succinate dehydrogenase iron-sulfur subu...	236	Conserved Gene / Pathway	Phase 2: March 2008	1NEK	77.2%	Vibrio cholerae	Energy metabolism	TCA cycle

IDP01446 (show subtarget assignments)	1	in_crystallization_trials	No	VC2099	15642099		flavodoxin FldA	175	Conserved Gene / Pathway	Phase 2: March 2008	1AG9	75.4%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01447 (show subtarget assignments)	1	in_crystallization_trials	No	VC2181	15642180	lolB	outer membrane lipoprotein LolB	211	Conserved Gene / Pathway	Phase 2: March 2008	1IWM	30.3%	Vibrio cholerae	Cell envelope	Other

IDP00280 (show subtarget assignments)	1	purified	No	AAX48017_51-545	604449	N/A	Envelope (E)	495	Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...	Phase 3: June 2008	3UAJ	79.2%	Dengue virus		N/A

IDP01142 (show subtarget assignments)	1	expressed	No	BA_1249	30255198	pabA-2	para-aminobenzoate synthase glutamine am...	195	Drug Target Function	Phase 2: March 2008	1QDL	43.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01350
(show subtarget assignments)

1

in_pdb
3EEV

No

VCA0300

15601065

chloramphenicol acetyltransferase

209

Drug Target Function

Phase 2: March 2008

3EEV

100%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01351
(show subtarget assignments)

1

cloned

No

VCA0387

15601150

toxin resistance protein

169

Conserved Gene / Pathway

Phase 2: March 2008

1YVO

31.4%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01352
(show subtarget assignments)

1

soluble

No

VCA0447

15601210

haemagglutinin associated protein

230

Conserved Gene / Pathway

Phase 2: March 2008

1G60

29.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01353
(show subtarget assignments)

1

expressed

No

VCA0646

15601404

conserved hypothetical protein/hemolysin...

605

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01354
(show subtarget assignments)

1

cloned

No

VC0003

15640035

trmE

tRNA modification GTPase TrmE

464

Conserved Gene / Pathway

Phase 2: March 2008

3GEH

37.9%

Vibrio cholerae

Cellular processes

Detoxification

IDP01355
(show subtarget assignments)

1

soluble

No

VC0008

15640040

amino acid ABC transporter, ATP-binding ...

245

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

51.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01356
(show subtarget assignments)

1

soluble

No

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01357
(show subtarget assignments)

1

in_pdb
3FWX

Yes

VC0046

15640078

def

peptide deformylase

169

Conserved Gene / Pathway

Phase 2: March 2008

3FWX

100%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP01358
(show subtarget assignments)

1

in_pdb
3QZ3

Yes

VC0078

15640110

ferritin

181

Conserved Gene / Pathway

Phase 2: March 2008

3QZ3

100%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01359
(show subtarget assignments)

1

soluble

No

VC0147

15640178

cell division protein FtsY

391

Conserved Gene / Pathway

Phase 2: March 2008

2YHS

67.5%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP01360
(show subtarget assignments)

1

purified

No

VC0148

15640179

cell division ATP-binding protein FtsE

233

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

35.6%

Vibrio cholerae

Cellular processes

Cell division

IDP01361
(show subtarget assignments)

1

expressed

No

VC0157

15640187

alkaline serine protease

535

Drug Target Function

Phase 2: March 2008

1S2N

35.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01362
(show subtarget assignments)

1

purified

No

VC0158

15640188

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

2JFN

49.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01363
(show subtarget assignments)

1

soluble

No

VC0171

15640201

peptide ABC transporter, periplasmic pep...

542

Conserved Gene / Pathway

Phase 2: March 2008

1DPE

27.1%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01364
(show subtarget assignments)

1

expressed

No

VC0200

15640230

iron(III) compound receptor

718

Conserved Gene / Pathway

Phase 2: March 2008

3QLB

33.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01365
(show subtarget assignments)

1

purified

No

VC0201

15640231

iron(III) ABC transporter, ATP-binding p...

285

Conserved Gene / Pathway

Phase 2: March 2008

1JJ7

28.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01366
(show subtarget assignments)

1

soluble

No

VC0202

15640232

iron(III) ABC transporter, periplasmic i...

319

Conserved Gene / Pathway

Phase 2: March 2008

1EFD

25.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01367
(show subtarget assignments)

1

purified

No

VC0224

15640254

lipopolysaccharide biosynthesis glycosyl...

259

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01368
(show subtarget assignments)

1

soluble

No

VC0238

15640268

transferase, hexapeptide repeat family

188

Drug Target Function

Phase 2: March 2008

3JQY

38.3%

Vibrio cholerae

Central intermediary metabolism

Other

IDP01369
(show subtarget assignments)

1

in_crystallization_trials

No

VC0244

15640274

perosamine synthase

367

Conserved Gene / Pathway

Phase 2: March 2008

3BN1

41.7%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01370
(show subtarget assignments)

1

purified

No

VC0247

15640277

lipopolysaccharide/O-antigen transport p...

271

Conserved Gene / Pathway

Phase 2: March 2008

1OXS

25.8%

Vibrio cholerae

Transport and binding proteins

Other

IDP01371
(show subtarget assignments)

1

in_crystallization_trials

No

VC0250

15640280

iron-containing alcohol dehydrogenase fa...

374

Conserved Gene / Pathway

Phase 2: March 2008

3OWO

28.3%

Vibrio cholerae

Energy metabolism

Fermentation

IDP01372
(show subtarget assignments)

1

in_pdb
3I99

No

VC0318

15640345

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

357

Drug Target Function

Phase 2: March 2008

3I99

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01373
(show subtarget assignments)

1

soluble

No

VC0335

15640362

NlpD-related protein

382

Drug Target Function

Phase 2: March 2008

3SLU

13.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01374
(show subtarget assignments)

1

purified

No

VC0344

15640371

N-acetylmuramoyl-L-alanine amidase

581

Conserved Gene / Pathway

Phase 2: March 2008

3NE8

13.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01375
(show subtarget assignments)

1

in_crystallization_trials

No

VC0372

15640399

alr

alanine racemase

375

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

57.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01376
(show subtarget assignments)

1

soluble

No

VC0400

15640427

MSHA biogenesis protein MshJ

216

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01377
(show subtarget assignments)

1

cloned

No

VC0409

15640436

MSHA pilin protein MshA

178

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01378
(show subtarget assignments)

1

cloned

No

VC0410

15640437

MSHA pilin protein MshC

162

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01379
(show subtarget assignments)

1

purified

No

VC0474

15640501

iron-regulated virulence regulatory prot...

298

Conserved Gene / Pathway

Phase 2: March 2008

3SZP

27.2%

Vibrio cholerae

Regulatory functions

Other

IDP01145
(show subtarget assignments)

1

expressed

No

BA_0188

30253695

oligopeptide ABC transporter, ATP-bindin...

257

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

34.6%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01381
(show subtarget assignments)

1

purified

No

VC0529

15640551

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

158

Drug Target Function

Phase 2: March 2008

1GX1

74.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP01383
(show subtarget assignments)

1

in_crystallization_trials

No

VC0538

15640560

thiosulfate ABC transporter, periplasmic...

333

Conserved Gene / Pathway

Phase 2: March 2008

1SBP

42.3%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01384
(show subtarget assignments)

1

purified

No

VC0554

15640576

protease, insulinase family/protease, in...

952

Drug Target Function

Phase 2: March 2008

1Q2L

19.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01385
(show subtarget assignments)

1

cloned

No

VC0560

15640582

signal recognition particle protein

461

Drug Target Function

Phase 2: March 2008

2XXA

73.1%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP00597
(show subtarget assignments)

1

purified

No

YPO3909

16124041

murI

glutamate racemase

287

Conserved Gene / Pathway

Phase 2: March 2008

2JFN

71.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01387
(show subtarget assignments)

1

cloned

No

VC0566

15640588

protease DO

456

Drug Target Function

Phase 2: March 2008

2ZLE

57.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01388
(show subtarget assignments)

1

soluble

No

VC0608

15640628

iron(III) ABC transporter, periplasmic i...

352

Conserved Gene / Pathway

Phase 2: March 2008

1Q35

55.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01389
(show subtarget assignments)

1

purified

No

VC0610

15640630

iron(III) ABC transporter, ATP-binding p...

343

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

36.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01390
(show subtarget assignments)

1

purified

No

VC0617

15640637

peptide ABC transporter, ATP-binding pro...

327

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

24.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01391
(show subtarget assignments)

1

cloned

No

VC0633

15640653

outer membrane protein OmpU

350

Conserved Gene / Pathway

Phase 2: March 2008

3HW9

27.3%

Vibrio cholerae

Cell envelope

Other

IDP01392
(show subtarget assignments)

1

purified

No

VC0648

15640668

lipoprotein NlpI

303

Conserved Gene / Pathway

Phase 2: March 2008

1XNF

44.2%

Vibrio cholerae

Cell envelope

Other

IDP01393
(show subtarget assignments)

1

in_crystallization_trials

No

VC0684

15640703

peptidyl-prolyl cis-trans isomerase, FKB...

144

Conserved Gene / Pathway

Phase 2: March 2008

2K8I

33.3%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01394
(show subtarget assignments)

1

soluble

No

VC0700

15640719

soluble lytic murein transglycosylase

648

Drug Target Function

Phase 2: March 2008

1QSA

33.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01395
(show subtarget assignments)

1

purified

No

VC0704

15640723

spermidine/putrescine ABC transporter, p...

359

Conserved Gene / Pathway

Phase 2: March 2008

3TTK

27.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01144
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5153

30259639

phosphoglucomutase/phosphomannomutase fa...

574

Drug Target Function

Phase 2: March 2008

2FUV

26.3%

Bacillus anthracis

Energy metabolism

Sugars

IDP01397
(show subtarget assignments)

1

purified

No

VC0755

161582019

aminopeptidase B

429

Drug Target Function

Phase 2: March 2008

3H8E

32.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01398
(show subtarget assignments)

1

cloned

No

VC0762

15640781

outer membrane protein assembly complex ...

386

Conserved Gene / Pathway

Phase 2: March 2008

3P1L

43.3%

Vibrio cholerae

Cell envelope

Other

IDP01399
(show subtarget assignments)

1

in_crystallization_trials

No

VC0771

15640790

vibriobactin-specific isochorismatase

293

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

44.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01400
(show subtarget assignments)

1

expressed

No

VC0772

15640791

vibriobactin-specific 2,3-dihydroxybenzo...

543

Conserved Gene / Pathway

Phase 2: March 2008

1MD9

51.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01401
(show subtarget assignments)

1

purified

No

VC0773

15640792

vibriobactin-specific isochorismate synt...

395

Drug Target Function

Phase 2: March 2008

3OS6

44.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01402
(show subtarget assignments)

1

cloned

No

VC0843

15640860

tagE protein

302

Drug Target Function

Phase 2: March 2008

3SLU

18.9%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01403
(show subtarget assignments)

1

in_crystallization_trials

No

VC0854

15640870

heat shock protein GrpE

200

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

39.5%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01404
(show subtarget assignments)

1

purified

No

VC0856

15640872

dnaJ protein

381

Conserved Gene / Pathway

Phase 2: March 2008

3LZ8

31.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01405
(show subtarget assignments)

1

purified

No

VC0905

161582017

metQ

lipoprotein YaeC

269

Conserved Gene / Pathway

Phase 2: March 2008

3K2D

72.9%

Vibrio cholerae

Cell envelope

Other

IDP01406
(show subtarget assignments)

1

crystallized

No

VC0918

15640934

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

413

Conserved Gene / Pathway

Phase 2: March 2008

3OJL

45.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01407
(show subtarget assignments)

1

cloned

No

VC0947

15640963

D-alanyl-D-alanine carboxypeptidase

391

Drug Target Function

Phase 2: March 2008

1NZO

52.2%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01408
(show subtarget assignments)

1

purified

No

VC0965

15640981

phosphoenolpyruvate-protein phosphotrans...

573

Conserved Gene / Pathway

Phase 2: March 2008

2KX9

74.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01409
(show subtarget assignments)

1

purified

No

VC0972

15640988

porin, putative

349

Conserved Gene / Pathway

Phase 2: March 2008

1PHO

20.9%

Vibrio cholerae

Transport and binding proteins

Porins

IDP01410
(show subtarget assignments)

1

in_crystallization_trials

No

VC1091

15641104

oligopeptide ABC transporter, periplasmi...

543

Conserved Gene / Pathway

Phase 2: March 2008

2Z23

53.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01411
(show subtarget assignments)

1

purified

No

VC1095

15641108

oligopeptide ABC transporter, ATP-bindin...

336

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

28%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01412
(show subtarget assignments)

1

purified

No

VC1122

15641135

cyclopropane-fatty-acyl-phospholipid syn...

432

Drug Target Function

Phase 2: March 2008

1KPI

18.7%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01413
(show subtarget assignments)

1

purified

No

VC1174

15641187

anthranilate synthase component I

523

Drug Target Function

Phase 2: March 2008

1I1Q

59.3%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP01414
(show subtarget assignments)

1

purified

No

VC1359

15641371

amino acid ABC transporter, ATP-binding ...

251

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01415
(show subtarget assignments)

1

in_crystallization_trials

No

VC1363

15641375

siroheme synthase component enzyme

312

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

29.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01416
(show subtarget assignments)

1

soluble

No

VC1410

15641421

multidrug resistance protein VceA

406

Conserved Gene / Pathway

Phase 2: March 2008

4DK1

15.3%

Vibrio cholerae

Transport and binding proteins

Other

IDP01417
(show subtarget assignments)

1

soluble

No

VC1414

15641425

thermostable carboxypeptidase 1

524

Drug Target Function

Phase 2: March 2008

3DWC

44.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01418
(show subtarget assignments)

1

purified

No

VC1424

15641435

spermidine/putrescine ABC transporter, p...

345

Conserved Gene / Pathway

Phase 2: March 2008

1POT

61.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01419
(show subtarget assignments)

1

in_crystallization_trials

No

VC1425

15641436

spermidine/putrescine ABC transporter, p...

366

Conserved Gene / Pathway

Phase 2: March 2008

1POT

52.7%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01420
(show subtarget assignments)

1

cloned

No

VC1496

15641505

carboxy-terminal protease

665

Drug Target Function

Phase 2: March 2008

1FC6

16.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01421
(show subtarget assignments)

1

soluble

No

VC1544

15641552

tonB2 protein

206

Conserved Gene / Pathway

Phase 2: March 2008

2K9K

34%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01422
(show subtarget assignments)

1

expressed

No

VC1549

15641557

glycerol-3-phosphate ABC transporter, pe...

434

Conserved Gene / Pathway

Phase 2: March 2008

2HEU

20%

Vibrio cholerae

Transport and binding proteins

Other

IDP01423
(show subtarget assignments)

1

purified

No

VC1552

15641560

ugpC

glycerol-3-phosphate ABC transporter, AT...

393

Conserved Gene / Pathway

Phase 2: March 2008

2D62

45.5%

Vibrio cholerae

Transport and binding proteins

Other

IDP01424
(show subtarget assignments)

1

purified

No

VC1568

15641576

ABC transporter, ATP-binding protein

233

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

49.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01425
(show subtarget assignments)

1

expressed

No

VC1630

15641635

ABC transporter, ATP-binding protein

227

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

37%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01426
(show subtarget assignments)

1

expressed

No

VC1680

15641684

peptide ABC transporter, periplasmic pep...

540

Conserved Gene / Pathway

Phase 2: March 2008

1DPP

35%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01427
(show subtarget assignments)

1

purified

No

VC1684

15641688

peptide ABC transporter, ATP-binding pro...

262

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

33.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01428
(show subtarget assignments)

1

purified

No

VC1709

15641713

zinc protease, insulinase family

922

Drug Target Function

Phase 2: March 2008

3CWW

19%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01429
(show subtarget assignments)

1

in_crystallization_trials

No

VC1849

15641851

peptidyl-prolyl cis-trans isomerase B

164

Conserved Gene / Pathway

Phase 2: March 2008

1LOP

64%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01430
(show subtarget assignments)

1

in_crystallization_trials

No

VC1863

15641865

amino acid ABC transporter, periplasmic ...

260

Conserved Gene / Pathway

Phase 2: March 2008

1LAF

39.2%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01431
(show subtarget assignments)

1

purified

No

VC1864

15641866

amino acid ABC transporter, ATP-binding ...

256

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

62.9%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01432
(show subtarget assignments)

1

cloned

No

VC1918

15641920

peptidyl-prolyl cis-trans isomerse D

619

Drug Target Function

Phase 2: March 2008

1M5Y

16%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01433
(show subtarget assignments)

1

purified

No

VC1922

15641924

clpP

ATP-dependent Clp protease proteolytic s...

200

Drug Target Function

Phase 2: March 2008

1TYF

76%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01434
(show subtarget assignments)

1

purified

No

VC1944

15641946

PvcB protein

287

Conserved Gene / Pathway

Phase 2: March 2008

3EAT

46%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01435
(show subtarget assignments)

1

purified

No

VC1956

15641958

lytic murein transglycosylase, putative ...

323

Drug Target Function

Phase 2: March 2008

4ANR

32.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01143
(show subtarget assignments)

1

in_pdb
3R8Y

No

BA_4194

30258698

2,3,4,5-tetrahydropyridine-2-carboxylate...

240

Drug Target Function

Phase 2: March 2008

3R8Y

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01437
(show subtarget assignments)

1

purified

No

VC1983

15641985

peptidase, putative

615

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01438
(show subtarget assignments)

1

expressed

No

VC1993

15641995

2,4-dienoyl-CoA reductase

666

Drug Target Function

Phase 2: March 2008

1PS9

56.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP01439
(show subtarget assignments)

1

crystallized

No

VC2019

15642021

3-oxoacyl-(acyl carrier protein) synthas...

414

Drug Target Function

Phase 2: March 2008

1B3N

74.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00596
(show subtarget assignments)

1

purified

No

YPO0555

16120883

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

78.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01441
(show subtarget assignments)

1

in_crystallization_trials

No

VC2023

15642025

3-oxoacyl-(acyl carrier protein) synthas...

316

Drug Target Function

Phase 2: March 2008

1EBL

72.6%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01442
(show subtarget assignments)

1

expressed

No

VC2048

15642050

vacJ lipoprotein

254

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Other

IDP01443
(show subtarget assignments)

1

soluble

No

VC2061

15642061

ParA family protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1WCV

34.1%

Vibrio cholerae

Cellular processes

Cell division

IDP01444
(show subtarget assignments)

1

soluble

No

VC2081

15642081

zinc ABC transporter, periplasmic zinc-b...

297

Conserved Gene / Pathway

Phase 2: March 2008

2OGW

44.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01445
(show subtarget assignments)

1

soluble

No

VC2088

15642088

sdhB

succinate dehydrogenase iron-sulfur subu...

236

Conserved Gene / Pathway

Phase 2: March 2008

1NEK

77.2%

Vibrio cholerae

Energy metabolism

TCA cycle

IDP01446
(show subtarget assignments)

1

in_crystallization_trials

No

VC2099

15642099

flavodoxin FldA

175

Conserved Gene / Pathway

Phase 2: March 2008

1AG9

75.4%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01447
(show subtarget assignments)

1

in_crystallization_trials

No

VC2181

15642180

lolB

outer membrane lipoprotein LolB

211

Conserved Gene / Pathway

Phase 2: March 2008

1IWM

30.3%

Vibrio cholerae

Cell envelope

Other

IDP00280
(show subtarget assignments)

1

purified

No

AAX48017_51-545

604449

N/A

Envelope (E)

495

Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...

Phase 3: June 2008

3UAJ

79.2%

Dengue virus

N/A

IDP01142
(show subtarget assignments)

1

expressed

No

BA_1249

30255198

pabA-2

para-aminobenzoate synthase glutamine am...

195

Drug Target Function

Phase 2: March 2008

1QDL

43.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

Targets