Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04085 (show subtarget assignments)	1	expressed	No	VC0525	15640547		2-amino-4-hydroxy-6-hydroxymethyldihydro...	195	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2BMB	30.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP01142 (show subtarget assignments)	1	expressed	No	BA_1249	30255198	pabA-2	para-aminobenzoate synthase glutamine am...	195	Drug Target Function	Phase 2: March 2008	1QDL	43.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP91982 (show subtarget assignments)	8	selected	No	SpneCM_010100007575	298255445		LysM domain protein [Streptococcus pneum...	195	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP90589 (show subtarget assignments)	8	soluble	No	VC0296	15640324		acetyl-CoA carboxylase [Vibrio cholerae ...	196	Predicted Essential	Community Requests	1A6X	37.2%	Vibrio cholerae

IDP02120 (show subtarget assignments)	1	expressed	No	YPO0027	16120380		phosphatase [Yersinia pestis CO92]	196	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2B0C	66.8%	Yersinia pestis	Unknown function	General

IDP90098 (show subtarget assignments)	8	purified	No	ZZZ_0014				196	This protein is a component of a type VI secretion system of enteroaggregative E...	Community Requests	3U66	19.4%	Escherichia coli

IDP05511 (show subtarget assignments)	1	soluble	No	BA_5634	30260085		putative lipoprotein [Bacillus anthracis...	196	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP91231 (show subtarget assignments)	8	soluble	No	NT04EC1793	26108012	ribA	GTP cyclohydrolase II [Escherichia coli ...	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	99.5%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91299 (show subtarget assignments)	8	cloned	No	STM1711	16765055	ribA	GTP cyclohydrolase II protein	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	95.4%	Salmonella enterica

IDP90370 (show subtarget assignments)	8	soluble	No	CT_263	3328675		hypothetical protein [Chlamydia trachoma...	196	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00433 (show subtarget assignments)	1	purified	No	YPO1545	16121818	hisH	imidazole glycerol phosphate synthase su...	196	Drug Target Function	Phase 2: March 2008	1GPW	35.3%	Yersinia pestis	Amino acid biosynthesis	Histidine family

IDP00400 (show subtarget assignments)	0	work_stopped	No	YPO2222	16122451	ribA	GTP cyclohydrolase II	196	Virulence Associated Factor	Phase 2: March 2008	2BZ0	88.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91617 (show subtarget assignments)	8	purified	No	BAB36908	13362956	ECs3485	chaperone-like protein [Escherichia coli...	196	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LW8	41.3%	Escherichia coli

IDP00075 (show subtarget assignments)	0	work_stopped	No	NTL01ST3174	16421824	yraO	putative phosphoheptose isomerase	196		Phase 1: October 2007	2YVA	98%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91289 (show subtarget assignments)	8	soluble	No	SPA1165	56413363	ribA	GTP cyclohydrolase II [Salmonella enteri...	196	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2BZ0	95.4%	Salmonella enterica

IDP01323 (show subtarget assignments)	1	cloned	No	VC2633	15642628		fimbrial assembly protein PilN, putative...	196	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cell envelope	Surface structures

IDP91632 (show subtarget assignments)	8	purified	No	BAB35248	13361290	ECs1825	bfpT-regulated chaperone-like protein [E...	196	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LW8	39.8%	Escherichia coli

IDP90845 (show subtarget assignments)	8	selected	No	S1357	30062792	btuR	cob(I)yrinic acid a,c-diamide adenosyltr...	196	Predicted Essential	Community Requests	1G5R	88.3%	Shigella flexneri

IDP04469 (show subtarget assignments)	1	cloned	No	YPO2214	115347921	btuR	cob(I)alamin adenosyltransferase [Yersin...	196	conserved gene; putative drug target function;	Phase 4: April 2009	1G5R	78.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04065 (show subtarget assignments)	1	cloned	No	CPF_2985	110800289	yyaC	putative sporulation protein YyaC [Clost...	196	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01654 (show subtarget assignments)	1	expressed	No	STM1259	16764611		putative ABC-type transport system ATPas...	196	Conserved; Drug target functions	Phase 3: June 2008	1Z47	31.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01636 (show subtarget assignments)	1	cloned	No	Cj1144c	15792469		hypothetical protein Cj1144c [Campylobac...	197	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01055 (show subtarget assignments)	1	crystallized	No	STM3371	16766666	maf	Maf-like protein	197	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	43.7%	Salmonella enterica	Cellular processes	Cell division

IDP91444 (show subtarget assignments)	8	cloned	No	VV1_0416	27363884		hypothetical protein VV1_0416 [Vibrio vu...	197	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP05159 (show subtarget assignments)	1	cloned	No	BA_1290	30255237	calY	camelysin [Bacillus anthracis str. Ames]...	197	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Sporulation and germination

IDP02377 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1442	47526717	cysC	adenylylsulfate kinase [Bacillus anthrac...	197	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3UIE	51.3%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP91919 (show subtarget assignments)	8	selected	No	SpneCM_010100003360	298254637		choline binding protein G [Streptococcus...	197	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1P3C	24.9%	Streptococcus pneumoniae

IDP01303 (show subtarget assignments)	1	purified	No	VC0573	15640595		ubiquinol--cytochrome c reductase, iron-...	197	Conserved Gene / Pathway	Phase 2: March 2008	2FYN	37.6%	Vibrio cholerae	Energy metabolism	Electron transport

IDP05472 (show subtarget assignments)	1	cloned	No	BA_2584	30257206		putative lipoprotein [Bacillus anthracis...	197	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP04120 (show subtarget assignments)	1	soluble	No	BAS1475	49184492		xanthine phosphoribosyltransferase [Baci...	197	Proposed to be essential proteins	Phase 4: April 2009	1Y0B	65%	Bacillus anthracis

IDP05089 (show subtarget assignments)	1	cloned	No	BA_4065	30258571		putative prophage LambdaBa02, lipoprotei...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05586 (show subtarget assignments)	1	expressed	No	BA_2746	30257351		putative lipoprotein [Bacillus anthracis...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP02349 (show subtarget assignments)	1	purified	No	GBAA5069	47778360		LPXTG-site transpeptidase family protein...	198	Drug target motif; Drug target functions	Phase 3: June 2008	2XWG	24.7%	Bacillus anthracis	Cell envelope	Other

IDP01974 (show subtarget assignments)	1	purified	No	lmo2468	16804506	clpP	ATP-dependent Clp protease proteolytic s...	198	Known virulence-Protease; PMID:11447171; Presence of Protease Motifs	Phase 3: June 2008	3QWD	76.3%	Listeria monocytogenes	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04448 (show subtarget assignments)	1	cloned	No	YPO0810	218927990		general secretion pathway protein J [Yer...	198	putative drug target function;	Phase 4: April 2009	2RET	20.2%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00950 (show subtarget assignments)	1	soluble	No	STM1119	16764477	wraB	TrpR binding protein WrbA	198	Conserved Gene / Pathway	Phase 2: March 2008	2R96	94.4%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP00026 (show subtarget assignments)	1	soluble	No	BA_0399	30253934		tellurium resistance protein, putative	198	Virulence	Phase 1: October 2007	3IBZ	41.9%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01967 (show subtarget assignments)	1	soluble	No	STM1789	16765130		hydrogenase 1 maturation protease [Salmo...	198	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1CFZ	30.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP02275 (show subtarget assignments)	1	cloned	No	FTT1158c	56708229		Type IV pili glycosylation protein [Fran...	198	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008			Francisella tularensis	Cell envelopeCellular processes	Surface structuresPathogenesis,Cell adhesion

IDP90939 (show subtarget assignments)	8	expressed	No	NMPDR 243277.1.peg.3882				198	Predicted Essential	Community Requests	2AU3	34.3%	Vibrio cholerae

IDP05029 (show subtarget assignments)	1	cloned	No	BA_0864	30254614		putative lipoprotein [Bacillus anthracis...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP92563 (show subtarget assignments)	8	selected	No	3E90_B	221046696		Chain B, West Nile Vi Rus Ns2b-Ns3protea...	198	potential drug target / We have identified a number of small molecule inhibitor to West Nile and/or deng...	Community Requests	3E90	100%	West Nile

IDP91727 (show subtarget assignments)	8	selected	No	NP_619527	20336315	BCL2L11	bcl-2-like protein 11 isoform 1 [Homo sa...	198	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2NL9	13.1%	Homo sapiens

IDP91583 (show subtarget assignments)	8	expressed	No	CBU_0329	29540941		hypothetical protein	198	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01951 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0809c	15792147		metallo-beta-lactamase family protein [C...	198	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	2ZWR	30.8%	Campylobacter jejuni	Unknown function	General

IDP05072 (show subtarget assignments)	1	cloned	No	CD3564	126701190	spoIIR	stage II sporulation protein [Clostridiu...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cellular processes: Sporulation and germination

IDP91182 (show subtarget assignments)	8	expressed	No	CT862	15605598	lcrH_2	type III secretion chaperone [Chlamydia ...	198	virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...	Community Requests	2VGX	17.2%	Chlamydia trachomatis

IDP02375 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4701	47530000	engB	GTPase EngB [Bacillus anthracis str. 'Am...	198	Conserved; Essential;	Phase 3: June 2008	1SUL	72.2%	Bacillus anthracis	Unknown function	General

IDP90509 (show subtarget assignments)	8	purified	No	Cj0347	15791715	trpF	N-(5'phosphoribosyl)anthranilate isomera...	199	Predicted Essential	Community Requests	1DL3	31.4%	Campylobacter jejuni

IDP01749 (show subtarget assignments)	1	purified	No	Cj1224	15792548		putative iron-binding protein [Campyloba...	199	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1A7D	18.1%	Campylobacter jejuni	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00698 (show subtarget assignments)	1	in_pdb 3V4E 3FTT	Yes	SACOL2570	57286478		galactoside O-acetyltransferase	199	Drug Target Function	Phase 2: March 2008	3FTT	100%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP05597 (show subtarget assignments)	1	soluble	No	BA_3378	30257921		hypothetical protein BA_3378 [Bacillus a...	199	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP01835 (show subtarget assignments)	1	cloned	No	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00633 (show subtarget assignments)	1	soluble	No	SACOL0118	57286667	sodA1	superoxide dismutase	199	Conserved Gene / Pathway	Phase 2: March 2008	1JR9	64.5%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00604 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1610	57286132	sodA2	superoxide dismutase	199	Conserved Gene / Pathway	Phase 2: March 2008	2RCV	71.8%	Staphylococcus aureus	Cellular processes	Detoxification

IDP90422 (show subtarget assignments)	8	cloned	No	CT_471	3328905		hypothetical protein [Chlamydia trachoma...	200	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02303 (show subtarget assignments)	1	cloned	No	FTT0530c	56707664		DJ-1/PfpI family protein [Francisella tu...	200	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3MGK	50.5%	Francisella tularensis	Unknown function	General

IDP02800 (show subtarget assignments)	1	soluble	No	GBAA4828	47530124	coaE	dephospho-CoA kinase [Bacillus anthracis...	200	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JJV	43.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05025 (show subtarget assignments)	1	cloned	No	BAS4742	49187733	-	hypothetical protein BAS4742 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP02610 (show subtarget assignments)	1	expressed	No	Cj1417c	15792735		hypothetical protein Cj1417c [Campylobac...	200	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1GEE	87.7%	Campylobacter jejuni	Cell envelope	Other

IDP90790 (show subtarget assignments)	8	in_pdb 3Q3W	Yes	Cj1716c	15793019	leuD	isopropylmalate isomerase small subunit ...	200	Predicted Essential	Community Requests	3Q3W	100%	Campylobacter jejuni

IDP02068 (show subtarget assignments)	1	crystallized	No	YPO3194	16123356	ahpC	putative alkyl hydroperoxide reductase s...	200	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1ZOF	59%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04514 (show subtarget assignments)	1	cloned	No	CPF_2662	110798713		putative spore-cortex-lytic enzyme [Clos...	200	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01433 (show subtarget assignments)	1	purified	No	VC1922	15641924	clpP	ATP-dependent Clp protease proteolytic s...	200	Drug Target Function	Phase 2: March 2008	1TYF	76%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01403 (show subtarget assignments)	1	in_crystallization_trials	No	VC0854	15640870		heat shock protein GrpE	200	Conserved Gene / Pathway	Phase 2: March 2008	1DKG	39.5%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP05393 (show subtarget assignments)	1	expressed	No	BA_3225	30257788		hypothetical protein BA_3225 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05636 (show subtarget assignments)	1	soluble	No	CD2388	126700003		putative peptidoglycan-binding/hydrolysi...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3BKH	17.5%	Clostridium difficile	Unknown function: General

IDP02367 (show subtarget assignments)	1	soluble	No	GBAA0213	47525471		1-acyl-sn-glycerol-3-phosphate acyltrans...	201	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01619 (show subtarget assignments)	1	expressed	No	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	Phase 3: June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02821 (show subtarget assignments)	1	in_pdb 3P2L	No	FTT0624	56707749	clpP	ATP-dependent Clp protease subunit P [Fr...	201	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3P2L	98.5%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02247 (show subtarget assignments)	1	expressed	No	FTT0665c	56707786		aldolase/adducin class II family protein...	201	Drug Target	Phase 3: June 2008	3OCR	32.3%	Francisella tularensis	Unknown function	General

IDP92086 (show subtarget assignments)	8	selected	No	ABB03945	77819088	SOD1	iron-containing superoxide dismutase [To...	201	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2A03	59.7%	Toxoplasma gondii

IDP04320 (show subtarget assignments)	1	in_pdb 4ESE	No	YPO2323	115348026	acpD	acyl carrier protein phosphodiesterase [...	201	conserved gene; putative drug target function;	Phase 4: April 2009	1T5B	81.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Other

IDP00349 (show subtarget assignments)	1	expressed	No	lmo1632	16803672	trpG	hypothetical protein lmo1632	201	Predicted involvement in glycosyl group metabolism; Drug Target Homologs	Phase 2: March 2008	1I1Q	39.3%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP90638 (show subtarget assignments)	8	soluble	No	VC1040	15641053		cob(I)yrinic acid a,c-diamide adenosyltr...	201	Predicted Essential	Community Requests	1G5R	64.2%	Vibrio cholerae

IDP01941 (show subtarget assignments)	1	purified	No	Cj1424c	15792742	gmhA2	putative phosphoheptose isomerase [Campy...	201	Known Predicted virulence-capsule biosynthesis anmd transport; Predicted Essenti...	Phase 3: June 2008	2X3Y	55.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP05236 (show subtarget assignments)	1	crystallized	No	lmo1533	16803573	ruvA	hypothetical protein lmo1533 [Listeria m...	201	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	34.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP00325 (show subtarget assignments)	1	crystallized	No	Cj1530	15792838	coaE	dephospho-CoA kinase	201	Drug Target Function	Phase 2: March 2008	2IF2	32.8%	Campylobacter jejuni	Unclassified	Unclassified

IDP91394 (show subtarget assignments)	8	purified	No	VV1_1133	27364552		hypothetical protein VV1_1133 [Vibrio vu...	201	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP00643 (show subtarget assignments)	1	purified	No	SACOL2638	57286542		precorrin-2 dehydrogenase	201	Conserved Gene / Pathway	Phase 2: March 2008	3DFZ	33.8%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02186 (show subtarget assignments)	1	soluble	No	FTT1672	56708682	ribB	riboflavin synthase subunit alpha [Franc...	201	Conserved; Drug target functions	Phase 3: June 2008	1KZL	35.8%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP00635 (show subtarget assignments)	1	cloned	No	SACOL2270	57286396	modC	molybdenum ABC transporter, ATP-binding ...	201	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	38.8%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP04032 (show subtarget assignments)	1	cloned	No	CPF_2081	110798910		stage III sporulation protein AG [Clostr...	201	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05279 (show subtarget assignments)	1	in_crystallization_trials	No	CD0254	126697825	flgD	putative basal-body rod modification pro...	202	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP00504 (show subtarget assignments)	1	expressed	No	YPO1015	16121316		hypothetical protein YPO1015	202	Drug Target Function	Phase 2: March 2008			Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00210 (show subtarget assignments)	1	crystallized	No	YPO0314	16120652	lexA	LexA repressor	202	Virulence	Phase 1: October 2007	1JHF	91.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP90707 (show subtarget assignments)	8	purified	No	Cj0233c	15791605	pyrE	orotate phosphoribosyltransferase [Campy...	202	Predicted Essential	Community Requests	2YZK	22.3%	Campylobacter jejuni

IDP05171 (show subtarget assignments)	1	expressed	No	lmo1439	16803479	sod	superoxide dismutase [Listeria monocytog...	202	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2RCV	73.3%	Listeria monocytogenes	Cellular processes: Detoxification

IDP01909 (show subtarget assignments)	1	soluble	No	STM1536	16764881		putative hydrogenase maturation protease...	202	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1CFZ	30.7%	Salmonella enterica	Energy metabolism	Aerobic

IDP04392 (show subtarget assignments)	1	cloned	No	CPF_1500	110798925		putative lipoprotein [Clostridium perfri...	202	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP91776 (show subtarget assignments)	8	in_crystallization_trials	No	ACM47288	222159815	vanXD	D,D-dipeptidase VanXD [Enterococcus faec...	202	drug resistance / D,D-dipeptidase	Community Requests	1R44	70.3%	Enterococcus faecium

IDP91773 (show subtarget assignments)	8	purified	No	AAB05628	1209532	vanXB	D,D-dipeptidase [Enterococcus faecalis]	202	drug resistance / D,D-dipeptidase	Community Requests	1R44	74.8%	Enterococcus faecalis

IDP01518 (show subtarget assignments)	1	purified	No	VC1512	15641521		formate dehydrogenase, iron-sulfur subun...	202	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	29%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP02066 (show subtarget assignments)	1	cloned	No	YPO1377	16121657	lolA	outer-membrane lipoprotein carrier prote...	202	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1IWL	66.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP90907 (show subtarget assignments)	8	purified	No	STM0643	16764020	cobC	alpha ribazole-5'-P phosphatase [Salmone...	202	Predicted Essential	Community Requests	2P9Z	30.7%	Salmonella enterica

IDP01803 (show subtarget assignments)	1	soluble	No	CBU_0646	29541247	ribE	riboflavin synthase, alpha subunit [Coxi...	202	Conserved; Drug target functions	Phase 3: June 2008	1I8D	37.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05084 (show subtarget assignments)	1	in_crystallization_trials	No	Z4803	12518085		putative ATP-dependent DNA helicase (tog...	202	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1OYW	33.7%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP02656 (show subtarget assignments)	1	expressed	No	FTT0558	56707688		short chain dehydrogenase [Francisella t...	203	Drug Target	Phase 3: June 2008	3D7L	41.9%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP90684 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1218c	15792542	ribA	riboflavin synthase subunit alpha [Campy...	203	Predicted Essential	Community Requests	1KZL	29.6%	Campylobacter jejuni

IDP04085
(show subtarget assignments)

1

expressed

No

VC0525

15640547

2-amino-4-hydroxy-6-hydroxymethyldihydro...

195

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2BMB

30.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP01142
(show subtarget assignments)

1

expressed

No

BA_1249

30255198

pabA-2

para-aminobenzoate synthase glutamine am...

195

Drug Target Function

Phase 2: March 2008

1QDL

43.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP91982
(show subtarget assignments)

8

selected

No

SpneCM_010100007575

298255445

LysM domain protein [Streptococcus pneum...

195

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP90589
(show subtarget assignments)

8

soluble

No

VC0296

15640324

acetyl-CoA carboxylase [Vibrio cholerae ...

196

Predicted Essential

Community Requests

1A6X

37.2%

Vibrio cholerae

IDP02120
(show subtarget assignments)

1

expressed

No

YPO0027

16120380

phosphatase [Yersinia pestis CO92]

196

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2B0C

66.8%

Yersinia pestis

Unknown function

General

IDP90098
(show subtarget assignments)

8

purified

No

ZZZ_0014

196

This protein is a component of a type VI secretion system of enteroaggregative E...

Community Requests

3U66

19.4%

Escherichia coli

IDP05511
(show subtarget assignments)

1

soluble

No

BA_5634

30260085

putative lipoprotein [Bacillus anthracis...

196

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP91231
(show subtarget assignments)

8

soluble

No

NT04EC1793

26108012

ribA

GTP cyclohydrolase II [Escherichia coli ...

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

99.5%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91299
(show subtarget assignments)

8

cloned

No

STM1711

16765055

ribA

GTP cyclohydrolase II protein

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

95.4%

Salmonella enterica

IDP90370
(show subtarget assignments)

8

soluble

No

CT_263

3328675

hypothetical protein [Chlamydia trachoma...

196

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00433
(show subtarget assignments)

1

purified

No

YPO1545

16121818

hisH

imidazole glycerol phosphate synthase su...

196

Drug Target Function

Phase 2: March 2008

1GPW

35.3%

Yersinia pestis

Amino acid biosynthesis

Histidine family

IDP00400
(show subtarget assignments)

0

work_stopped

No

YPO2222

16122451

ribA

GTP cyclohydrolase II

196

Virulence Associated Factor

Phase 2: March 2008

2BZ0

88.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91617
(show subtarget assignments)

8

purified

No

BAB36908

13362956

ECs3485

chaperone-like protein [Escherichia coli...

196

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LW8

41.3%

Escherichia coli

IDP00075
(show subtarget assignments)

0

work_stopped

No

NTL01ST3174

16421824

yraO

putative phosphoheptose isomerase

196

Phase 1: October 2007

2YVA

98%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91289
(show subtarget assignments)

8

soluble

No

SPA1165

56413363

ribA

GTP cyclohydrolase II [Salmonella enteri...

196

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2BZ0

95.4%

Salmonella enterica

IDP01323
(show subtarget assignments)

1

cloned

No

VC2633

15642628

fimbrial assembly protein PilN, putative...

196

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cell envelope

Surface structures

IDP91632
(show subtarget assignments)

8

purified

No

BAB35248

13361290

ECs1825

bfpT-regulated chaperone-like protein [E...

196

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LW8

39.8%

Escherichia coli

IDP90845
(show subtarget assignments)

8

selected

No

S1357

30062792

btuR

cob(I)yrinic acid a,c-diamide adenosyltr...

196

Predicted Essential

Community Requests

1G5R

88.3%

Shigella flexneri

IDP04469
(show subtarget assignments)

1

cloned

No

YPO2214

115347921

btuR

cob(I)alamin adenosyltransferase [Yersin...

196

conserved gene; putative drug target function;

Phase 4: April 2009

1G5R

78.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04065
(show subtarget assignments)

1

cloned

No

CPF_2985

110800289

yyaC

putative sporulation protein YyaC [Clost...

196

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01654
(show subtarget assignments)

1

expressed

No

STM1259

16764611

putative ABC-type transport system ATPas...

196

Conserved; Drug target functions

Phase 3: June 2008

1Z47

31.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01636
(show subtarget assignments)

1

cloned

No

Cj1144c

15792469

hypothetical protein Cj1144c [Campylobac...

197

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01055
(show subtarget assignments)

1

crystallized

No

STM3371

16766666

maf

Maf-like protein

197

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

43.7%

Salmonella enterica

Cellular processes

Cell division

IDP91444
(show subtarget assignments)

8

cloned

No

VV1_0416

27363884

hypothetical protein VV1_0416 [Vibrio vu...

197

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP05159
(show subtarget assignments)

1

cloned

No

BA_1290

30255237

calY

camelysin [Bacillus anthracis str. Ames]...

197

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP02377
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1442

47526717

cysC

adenylylsulfate kinase [Bacillus anthrac...

197

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3UIE

51.3%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP91919
(show subtarget assignments)

8

selected

No

SpneCM_010100003360

298254637

choline binding protein G [Streptococcus...

197

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1P3C

24.9%

Streptococcus pneumoniae

IDP01303
(show subtarget assignments)

1

purified

No

VC0573

15640595

ubiquinol--cytochrome c reductase, iron-...

197

Conserved Gene / Pathway

Phase 2: March 2008

2FYN

37.6%

Vibrio cholerae

Energy metabolism

Electron transport

IDP05472
(show subtarget assignments)

1

cloned

No

BA_2584

30257206

putative lipoprotein [Bacillus anthracis...

197

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP04120
(show subtarget assignments)

1

soluble

No

BAS1475

49184492

xanthine phosphoribosyltransferase [Baci...

197

Proposed to be essential proteins

Phase 4: April 2009

1Y0B

65%

Bacillus anthracis

IDP05089
(show subtarget assignments)

1

cloned

No

BA_4065

30258571

putative prophage LambdaBa02, lipoprotei...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05586
(show subtarget assignments)

1

expressed

No

BA_2746

30257351

putative lipoprotein [Bacillus anthracis...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP02349
(show subtarget assignments)

1

purified

No

GBAA5069

47778360

LPXTG-site transpeptidase family protein...

198

Drug target motif; Drug target functions

Phase 3: June 2008

2XWG

24.7%

Bacillus anthracis

Cell envelope

Other

IDP01974
(show subtarget assignments)

1

purified

No

lmo2468

16804506

clpP

ATP-dependent Clp protease proteolytic s...

198

Known virulence-Protease; PMID:11447171; Presence of Protease Motifs

Phase 3: June 2008

3QWD

76.3%

Listeria monocytogenes

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04448
(show subtarget assignments)

1

cloned

No

YPO0810

218927990

general secretion pathway protein J [Yer...

198

putative drug target function;

Phase 4: April 2009

2RET

20.2%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00950
(show subtarget assignments)

1

soluble

No

STM1119

16764477

wraB

TrpR binding protein WrbA

198

Conserved Gene / Pathway

Phase 2: March 2008

2R96

94.4%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP00026
(show subtarget assignments)

1

soluble

No

BA_0399

30253934

tellurium resistance protein, putative

198

Virulence

Phase 1: October 2007

3IBZ

41.9%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01967
(show subtarget assignments)

1

soluble

No

STM1789

16765130

hydrogenase 1 maturation protease [Salmo...

198

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1CFZ

30.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP02275
(show subtarget assignments)

1

cloned

No

FTT1158c

56708229

Type IV pili glycosylation protein [Fran...

198

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

Francisella tularensis

Cell envelopeCellular processes

Surface structuresPathogenesis,Cell adhesion

IDP90939
(show subtarget assignments)

8

expressed

No

NMPDR 243277.1.peg.3882

198

Predicted Essential

Community Requests

2AU3

34.3%

Vibrio cholerae

IDP05029
(show subtarget assignments)

1

cloned

No

BA_0864

30254614

putative lipoprotein [Bacillus anthracis...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP92563
(show subtarget assignments)

8

selected

No

3E90_B

221046696

Chain B, West Nile Vi Rus Ns2b-Ns3protea...

198

potential drug target / We have identified a number of small molecule inhibitor to West Nile and/or deng...

Community Requests

3E90

100%

West Nile

IDP91727
(show subtarget assignments)

8

selected

No

NP_619527

20336315

BCL2L11

bcl-2-like protein 11 isoform 1 [Homo sa...

198

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2NL9

13.1%

Homo sapiens

IDP91583
(show subtarget assignments)

8

expressed

No

CBU_0329

29540941

hypothetical protein

198

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01951
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0809c

15792147

metallo-beta-lactamase family protein [C...

198

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

2ZWR

30.8%

Campylobacter jejuni

Unknown function

General

IDP05072
(show subtarget assignments)

1

cloned

No

CD3564

126701190

spoIIR

stage II sporulation protein [Clostridiu...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cellular processes: Sporulation and germination

IDP91182
(show subtarget assignments)

8

expressed

No

CT862

15605598

lcrH_2

type III secretion chaperone [Chlamydia ...

198

virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...

Community Requests

2VGX

17.2%

Chlamydia trachomatis

IDP02375
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4701

47530000

engB

GTPase EngB [Bacillus anthracis str. 'Am...

198

Conserved; Essential;

Phase 3: June 2008

1SUL

72.2%

Bacillus anthracis

Unknown function

General

IDP90509
(show subtarget assignments)

8

purified

No

Cj0347

15791715

trpF

N-(5'phosphoribosyl)anthranilate isomera...

199

Predicted Essential

Community Requests

1DL3

31.4%

Campylobacter jejuni

IDP01749
(show subtarget assignments)

1

purified

No

Cj1224

15792548

putative iron-binding protein [Campyloba...

199

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1A7D

18.1%

Campylobacter jejuni

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00698
(show subtarget assignments)

1

in_pdb
3V4E
3FTT

Yes

SACOL2570

57286478

galactoside O-acetyltransferase

199

Drug Target Function

Phase 2: March 2008

3FTT

100%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP05597
(show subtarget assignments)

1

soluble

No

BA_3378

30257921

hypothetical protein BA_3378 [Bacillus a...

199

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP01835
(show subtarget assignments)

1

cloned

No

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00633
(show subtarget assignments)

1

soluble

No

SACOL0118

57286667

sodA1

superoxide dismutase

199

Conserved Gene / Pathway

Phase 2: March 2008

1JR9

64.5%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00604
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1610

57286132

sodA2

superoxide dismutase

199

Conserved Gene / Pathway

Phase 2: March 2008

2RCV

71.8%

Staphylococcus aureus

Cellular processes

Detoxification

IDP90422
(show subtarget assignments)

8

cloned

No

CT_471

3328905

hypothetical protein [Chlamydia trachoma...

200

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02303
(show subtarget assignments)

1

cloned

No

FTT0530c

56707664

DJ-1/PfpI family protein [Francisella tu...

200

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3MGK

50.5%

Francisella tularensis

Unknown function

General

IDP02800
(show subtarget assignments)

1

soluble

No

GBAA4828

47530124

coaE

dephospho-CoA kinase [Bacillus anthracis...

200

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JJV

43.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05025
(show subtarget assignments)

1

cloned

No

BAS4742

49187733

-

hypothetical protein BAS4742 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP02610
(show subtarget assignments)

1

expressed

No

Cj1417c

15792735

hypothetical protein Cj1417c [Campylobac...

200

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1GEE

87.7%

Campylobacter jejuni

Cell envelope

Other

IDP90790
(show subtarget assignments)

8

in_pdb
3Q3W

Yes

Cj1716c

15793019

leuD

isopropylmalate isomerase small subunit ...

200

Predicted Essential

Community Requests

3Q3W

100%

Campylobacter jejuni

IDP02068
(show subtarget assignments)

1

crystallized

No

YPO3194

16123356

ahpC

putative alkyl hydroperoxide reductase s...

200

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1ZOF

59%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04514
(show subtarget assignments)

1

cloned

No

CPF_2662

110798713

putative spore-cortex-lytic enzyme [Clos...

200

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01433
(show subtarget assignments)

1

purified

No

VC1922

15641924

clpP

ATP-dependent Clp protease proteolytic s...

200

Drug Target Function

Phase 2: March 2008

1TYF

76%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01403
(show subtarget assignments)

1

in_crystallization_trials

No

VC0854

15640870

heat shock protein GrpE

200

Conserved Gene / Pathway

Phase 2: March 2008

1DKG

39.5%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP05393
(show subtarget assignments)

1

expressed

No

BA_3225

30257788

hypothetical protein BA_3225 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05636
(show subtarget assignments)

1

soluble

No

CD2388

126700003

putative peptidoglycan-binding/hydrolysi...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3BKH

17.5%

Clostridium difficile

Unknown function: General

IDP02367
(show subtarget assignments)

1

soluble

No

GBAA0213

47525471

1-acyl-sn-glycerol-3-phosphate acyltrans...

201

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01619
(show subtarget assignments)

1

expressed

No

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

Phase 3: June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02821
(show subtarget assignments)

1

in_pdb
3P2L

No

FTT0624

56707749

clpP

ATP-dependent Clp protease subunit P [Fr...

201

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3P2L

98.5%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02247
(show subtarget assignments)

1

expressed

No

FTT0665c

56707786

aldolase/adducin class II family protein...

201

Drug Target

Phase 3: June 2008

3OCR

32.3%

Francisella tularensis

Unknown function

General

IDP92086
(show subtarget assignments)

8

selected

No

ABB03945

77819088

SOD1

iron-containing superoxide dismutase [To...

201

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2A03

59.7%

Toxoplasma gondii

IDP04320
(show subtarget assignments)

1

in_pdb
4ESE

No

YPO2323

115348026

acpD

acyl carrier protein phosphodiesterase [...

201

conserved gene; putative drug target function;

Phase 4: April 2009

1T5B

81.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Other

IDP00349
(show subtarget assignments)

1

expressed

No

lmo1632

16803672

trpG

hypothetical protein lmo1632

201

Predicted involvement in glycosyl group metabolism; Drug Target Homologs

Phase 2: March 2008

1I1Q

39.3%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP90638
(show subtarget assignments)

8

soluble

No

VC1040

15641053

cob(I)yrinic acid a,c-diamide adenosyltr...

201

Predicted Essential

Community Requests

1G5R

64.2%

Vibrio cholerae

IDP01941
(show subtarget assignments)

1

purified

No

Cj1424c

15792742

gmhA2

putative phosphoheptose isomerase [Campy...

201

Known Predicted virulence-capsule biosynthesis anmd transport; Predicted Essenti...

Phase 3: June 2008

2X3Y

55.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP05236
(show subtarget assignments)

1

crystallized

No

lmo1533

16803573

ruvA

hypothetical protein lmo1533 [Listeria m...

201

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

34.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP00325
(show subtarget assignments)

1

crystallized

No

Cj1530

15792838

coaE

dephospho-CoA kinase

201

Drug Target Function

Phase 2: March 2008

2IF2

32.8%

Campylobacter jejuni

Unclassified

IDP91394
(show subtarget assignments)

8

purified

No

VV1_1133

27364552

hypothetical protein VV1_1133 [Vibrio vu...

201

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP00643
(show subtarget assignments)

1

purified

No

SACOL2638

57286542

precorrin-2 dehydrogenase

201

Conserved Gene / Pathway

Phase 2: March 2008

3DFZ

33.8%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02186
(show subtarget assignments)

1

soluble

No

FTT1672

56708682

ribB

riboflavin synthase subunit alpha [Franc...

201

Conserved; Drug target functions

Phase 3: June 2008

1KZL

35.8%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP00635
(show subtarget assignments)

1

cloned

No

SACOL2270

57286396

modC

molybdenum ABC transporter, ATP-binding ...

201

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

38.8%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP04032
(show subtarget assignments)

1

cloned

No

CPF_2081

110798910

stage III sporulation protein AG [Clostr...

201

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05279
(show subtarget assignments)

1

in_crystallization_trials

No

CD0254

126697825

flgD

putative basal-body rod modification pro...

202

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP00504
(show subtarget assignments)

1

expressed

No

YPO1015

16121316

hypothetical protein YPO1015

202

Drug Target Function

Phase 2: March 2008

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00210
(show subtarget assignments)

1

crystallized

No

YPO0314

16120652

lexA

LexA repressor

202

Virulence

Phase 1: October 2007

1JHF

91.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP90707
(show subtarget assignments)

8

purified

No

Cj0233c

15791605

pyrE

orotate phosphoribosyltransferase [Campy...

202

Predicted Essential

Community Requests

2YZK

22.3%

Campylobacter jejuni

IDP05171
(show subtarget assignments)

1

expressed

No

lmo1439

16803479

sod

superoxide dismutase [Listeria monocytog...

202

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2RCV

73.3%

Listeria monocytogenes

Cellular processes: Detoxification

IDP01909
(show subtarget assignments)

1

soluble

No

STM1536

16764881

putative hydrogenase maturation protease...

202

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1CFZ

30.7%

Salmonella enterica

Energy metabolism

Aerobic

IDP04392
(show subtarget assignments)

1

cloned

No

CPF_1500

110798925

putative lipoprotein [Clostridium perfri...

202

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP91776
(show subtarget assignments)

8

in_crystallization_trials

No

ACM47288

222159815

vanXD

D,D-dipeptidase VanXD [Enterococcus faec...

202

drug resistance / D,D-dipeptidase

Community Requests

1R44

70.3%

Enterococcus faecium

IDP91773
(show subtarget assignments)

8

purified

No

AAB05628

1209532

vanXB

D,D-dipeptidase [Enterococcus faecalis]

202

drug resistance / D,D-dipeptidase

Community Requests

1R44

74.8%

Enterococcus faecalis

IDP01518
(show subtarget assignments)

1

purified

No

VC1512

15641521

formate dehydrogenase, iron-sulfur subun...

202

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

29%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP02066
(show subtarget assignments)

1

cloned

No

YPO1377

16121657

lolA

outer-membrane lipoprotein carrier prote...

202

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1IWL

66.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP90907
(show subtarget assignments)

8

purified

No

STM0643

16764020

cobC

alpha ribazole-5'-P phosphatase [Salmone...

202

Predicted Essential

Community Requests

2P9Z

30.7%

Salmonella enterica

IDP01803
(show subtarget assignments)

1

soluble

No

CBU_0646

29541247

ribE

riboflavin synthase, alpha subunit [Coxi...

202

Conserved; Drug target functions

Phase 3: June 2008

1I8D

37.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05084
(show subtarget assignments)

1

in_crystallization_trials

No

Z4803

12518085

putative ATP-dependent DNA helicase (tog...

202

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1OYW

33.7%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP02656
(show subtarget assignments)

1

expressed

No

FTT0558

56707688

short chain dehydrogenase [Francisella t...

203

Drug Target

Phase 3: June 2008

3D7L

41.9%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP90684
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1218c

15792542

ribA

riboflavin synthase subunit alpha [Campy...

203

Predicted Essential

Community Requests

1KZL

29.6%

Campylobacter jejuni