Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04196 (show subtarget assignments)	1	cloned	No	CPF_2502	110800817		putative lipoprotein [Clostridium perfri...	507	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP90343 (show subtarget assignments)	8	expressed	No	CT148	15604867	mhpA	FAD-dependent monooxygenase [Chlamydia t...	507	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00653 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0451	57286824	ahpF	alkyl hydroperoxide reductase, subunit F...	507	Conserved Gene / Pathway	Phase 2: March 2008	1HYU	53.8%	Staphylococcus aureus	Cellular processes	Detoxification

IDP04331 (show subtarget assignments)	1	purified	No	CPF_2181	110799592		sensor histidine kinase [Clostridium per...	507	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.4%	Clostridium perfringens	Signal transduction	Two-component systems

IDP05495 (show subtarget assignments)	1	cloned	No	CD0237	126697808	fliD	flagellar cap protein [Clostridium diffi...	507	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02591 (show subtarget assignments)	1	crystallized	No	YPO3383	16123532	dgt	deoxyguanosinetriphosphate triphosphohyd...	506	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2PGS	29.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP92103 (show subtarget assignments)	8	selected	No	TGME49_097970	237843837		aspartyl aminopeptidase, putative [Toxop...	506	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3VAR	40.7%	Toxoplasma gondii

IDP05425 (show subtarget assignments)	1	soluble	No	lmo0355	16802400	-	fumarate reductase flavoprotein subunit ...	506	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1D4C	40.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP04554 (show subtarget assignments)	1	cloned	No	STM0791_1_506	16764154	hutH	histidine ammonia-lyase [Salmonella typh...	506	Salmonella essential protein	Phase 4: April 2009	1GK2	76.5%	Salmonella enterica

IDP01452 (show subtarget assignments)	1	soluble	No	VC2400	15642397	murC	UDP-N-acetylmuramate--L-alanine ligase	506	Conserved Gene / Pathway	Phase 2: March 2008	2F00	69.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04475 (show subtarget assignments)	1	cloned	No	YPO2772	115348455	purF	amidophosphoribosyltransferase [Yersinia...	505	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1ECB	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90637 (show subtarget assignments)	8	soluble	No	YPO0888	16121193	lysS	lysyl-tRNA synthetase [Yersinia pestis C...	505	Predicted Essential	Community Requests	1BBU	85.7%	Yersinia pestis

IDP92091 (show subtarget assignments)	8	selected	No	TGME49_014210	237842913		centromere/microtubule binding protein, ...	505	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3U28	49.9%	Toxoplasma gondii

IDP00734 (show subtarget assignments)	1	purified	No	SACOL0841	57284303	pgm	phosphoglyceromutase	505	Drug Target Function	Phase 2: March 2008	1EJJ	62%	Staphylococcus aureus	Energy metabolism	Glycolysis/gluconeogenesis

IDP92032 (show subtarget assignments)	8	selected	No	TGME49_019800	237842869		vacuolar ATP synthase subunit B, putativ...	505	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C61	53.9%	Toxoplasma gondii

IDP00726 (show subtarget assignments)	1	purified	No	SACOL1929	57286276		ABC transporter, ATP-binding protein, pu...	505	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP01218 (show subtarget assignments)	1	expressed	No	BA_3712	73919984		Histidine ammonia-lyase (Histidase)	505	Drug Target Function	Phase 2: March 2008	1GK2	42%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP01173 (show subtarget assignments)	1	cloned	No	BA_1587	30255887		thermostable carboxypeptidase 1	505	Drug Target Function	Phase 2: March 2008	3HQ2	60.8%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91709 (show subtarget assignments)	8	selected	No	NP_006107	5174703	TAB1	TGF-beta-activated kinase 1 and MAP3K7-b...	504	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2J4O	79.6%	Homo sapiens

IDP04344 (show subtarget assignments)	1	in_crystallization_trials	No	VC1004	15641019		amidophosphoribosyltransferase [Vibrio c...	504	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	76.1%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02526 (show subtarget assignments)	1	cloned	No	FTT1600c	56708620	fumA	fumerate hydratase [Francisella tularens...	504	Drug Target	Phase 3: June 2008	2ISB	13.7%	Francisella tularensis	Energy metabolism	TCA cycle

IDP02272 (show subtarget assignments)	1	cloned	No	GBAA2183	47527475		neutral metalloprotease, putative [Bacil...	503	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	1BQB	14.3%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00753 (show subtarget assignments)	1	cloned	No	SACOL0052	57286607		glycosyl transferase, group 1 family pro...	503	Conserved Gene / Pathway	Phase 2: March 2008	2F9F	9.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00161 (show subtarget assignments)	1	soluble	No	VC0835	15640852	tcpT	toxin co-regulated pilus biosynthesis pr...	503	Virulence	Phase 1: October 2007	1P9R	23.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP04709 (show subtarget assignments)	1	cloned	No	YPO0501	115346310		conserved hypothetical protein [Yersinia...	503	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP91004 (show subtarget assignments)	8	soluble	No	y1935	22125827		cysteine desulfurase activator complex s...	503	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	4DN7	18.7%	Yersinia pestis

IDP01197 (show subtarget assignments)	0	work_stopped	No	BA_1389	81715334		D-alanine--poly(phosphoribitol) ligase s...	503	Conserved Gene / Pathway	Phase 2: March 2008	3DHV	99.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02238 (show subtarget assignments)	1	expressed	No	YPO0815	16121126		general secretion pathway protein E [Yer...	503	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	48.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP00834 (show subtarget assignments)	1	expressed	No	SACOL2670	57286574		glycosyl transferase, group 1 family pro...	502	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	10.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02396 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3604	47528890	argH-1	argininosuccinate lyase [Bacillus anthra...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2E9F	27.5%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP01821 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5549	47530869	atpA	F0F1 ATP synthase subunit alpha [Bacillu...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	84.5%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP90685 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0401	15791768	lysS	lysyl-tRNA synthetase [Campylobacter jej...	501	Predicted Essential	Community Requests	1BBU	48.1%	Campylobacter jejuni

IDP91968 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100007436	298255418		zinc-binding lipoprotein AdcA [Streptoco...	501	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2O1E	29.5%	Streptococcus pneumoniae

IDP90196 (show subtarget assignments)	8	cloned	No	AAM13643.1	20153182	CPXV204 CDS	CPXV204 protein	501	kelch-like protein	Community Requests	2VPJ	14%	Cowpox virus	conserved hypothetical proteins	0

IDP01828 (show subtarget assignments)	1	in_pdb 3NZT	Yes	FTT0367c	56707518	gshA	glutamate--cysteine ligase [Francisella ...	501	Drug Target	Phase 3: June 2008	3NZT	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP01496 (show subtarget assignments)	1	soluble	No	VCA0813	15601568		aminopeptidase	501	Drug Target Function	Phase 2: March 2008	1RTQ	43.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91452 (show subtarget assignments)	8	purified	No	VV1_0376	27363845		Type IV secretory pathway, VirD2 compone...	501	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP04407 (show subtarget assignments)	1	cloned	No	CPF_0677	110799553	purH	bifunctional phosphoribosylaminoimidazol...	501	conserved gene; putative drug target function;	Phase 4: April 2009	3ZZM	41.1%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04659 (show subtarget assignments)	1	soluble	No	GBAA0272	47525531		sensor histidine kinase [Bacillus anthra...	501	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP91238 (show subtarget assignments)	8	cloned	No	HP1282	2314448		anthranilate synthase component I (trpE)...	500	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I1Q	46.8%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP04130 (show subtarget assignments)	1	cloned	No	YPO2938	115348602		conserved hypothetical protein [Yersinia...	500	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP91746 (show subtarget assignments)	8	selected	No	Q8BDF8_9POXV	0			500	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests			Vaccinia virus

IDP92060 (show subtarget assignments)	8	selected	No	TGME49_063190	237832243		adenylosuccinate lyase, putative [Toxopl...	500	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2PTS	43.2%	Toxoplasma gondii

IDP05177 (show subtarget assignments)	1	cloned	No	BA_2974	30257564	mqo	malate:quinone-oxidoreductase [Bacillus ...	500	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Energy metabolism: TCA cycle

IDP00573 (show subtarget assignments)	1	in_pdb 3GO9	No	YPO3991	16124118		putative insulinase family protease	499	Drug Target Function	Phase 2: March 2008	3GO9	98.6%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02569 (show subtarget assignments)	1	cloned	No	lmo0264	16802310	inlE	internalin E [Listeria monocytogenes EGD...	499	Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815 ; Predicte...	Phase 3: June 2008	1H6U	44.9%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP04043 (show subtarget assignments)	1	soluble	No	VCA0565	15601324		sensor histidine kinase [Vibrio cholerae...	499	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1BXD	6%	Vibrio cholerae	Regulatory functions	Other

IDP00216 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2310	16122534	-	putative carboxypeptidase	499	Virulence	Phase 1: October 2007	3DWC	48.1%	Yersinia pestis	Regulatory functions	Other

IDP05308 (show subtarget assignments)	1	soluble	No	CD3420	126701043	hemD	porphyrin biosynthesis protein [Clostrid...	499	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1PJQ	25.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04576 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0076	49183111		lysyl-tRNA synthetase [Bacillus anthraci...	499	Proposed to be essential proteins	Phase 4: April 2009	3A74	77.6%	Bacillus anthracis

IDP90280 (show subtarget assignments)	8	selected	No	TGME49_004420	211965378		oocyst wall protein COWP, putative [Toxo...	499	Unpublished data from a differentiation mutagenesis screen indicate that the ooc...	Community Requests	1N7D	19%	Toxoplasma gondii

IDP05208 (show subtarget assignments)	1	cloned	No	CD2373	126699988		putative carbon starvation protein [Clos...	499	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP04013 (show subtarget assignments)	1	cloned	No	STM2913_1_498	16766219		putative permease [Salmonella typhimuriu...	498	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP04669 (show subtarget assignments)	1	expressed	No	GBAA1351	47526623		sensor histidine kinase KinD [Bacillus a...	498	putative drug target function;	Phase 4: April 2009	3D36	15.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP00743 (show subtarget assignments)	1	in_pdb 3G25 3GE1	Yes	SACOL1320	57286055	glpK	glycerol kinase	498	Drug Target Function	Phase 2: March 2008	3G25	100%	Staphylococcus aureus	Energy metabolism	Other

IDP01879 (show subtarget assignments)	1	cloned	No	FTT1804c	56708790	rng	ribonuclease G [Francisella tularensis s...	498	Conserved; Drug target functions	Phase 3: June 2008	2BX2	31.9%	Francisella tularensis	Cellular processesTranscription	Cell divisionRNA processing

IDP02443 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0228	16802274	lysS	lysyl-tRNA synthetase [Listeria monocyto...	498	Predicted involvement or location on the cell wall; Drug Target Homologs	Phase 3: June 2008	3A74	69.7%	Listeria monocytogenes	Protein synthesis	tRNA aminoacylation

IDP90802 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3769	16123905		3-octaprenyl-4-hydroxybenzoate decarboxy...	498	Predicted Essential	Community Requests	2IDB	88.2%	Yersinia pestis

IDP04505 (show subtarget assignments)	1	soluble	No	VCA0531	15601291		sensor histidine kinase [Vibrio cholerae...	497	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	15.9%	Vibrio cholerae	Regulatory functions	Other

IDP91482 (show subtarget assignments)	8	expressed	No	VPA0450	28900305		hypothetical protein VPA0450 [Vibrio par...	497	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP01794 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1026	47526305	glpK	glycerol kinase [Bacillus anthracis str....	496	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3G25	75%	Bacillus anthracis	Energy metabolism	Other

IDP01670 (show subtarget assignments)	1	cloned	No	GBAA0156	47525414		hypothetical protein GBAA0156 [Bacillus ...	496	Conserved;	Phase 3: June 2008	2KQ1	6.7%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP00776 (show subtarget assignments)	1	crystallized	No	SACOL0612	57285627		glycosyl transferase, group 1 family pro...	496	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	11.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00699 (show subtarget assignments)	1	in_pdb 3ED6 3FG0	Yes	SACOL2628	57286533	betB	betaine aldehyde dehydrogenase	496	Conserved Gene / Pathway	Phase 2: March 2008	3ED6	100%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP00675 (show subtarget assignments)	1	cloned	No	SACOL1455	57284564		carboxyl-terminal protease	496	Drug Target Function	Phase 2: March 2008	1FC6	20%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91585 (show subtarget assignments)	8	cloned	No	CBU_0635	29541236		hypothetical protein	496	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP04657 (show subtarget assignments)	1	expressed	No	FTT1721c	56708727	purF	amidophosphoribosyltransferase [Francise...	496	conserved gene; putative drug target function;	Phase 4: April 2009	1ECB	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP02462 (show subtarget assignments)	1	expressed	No	FTT1467c	56708507	nadB	L-aspartate oxidase [Francisella tularen...	495	Conserved; Drug target functions	Phase 3: June 2008	1CHU	38.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP00272 (show subtarget assignments)	1	in_pdb 3EGP 3IRC	No	AF180817_281-775	7329982	N/A	Envelope (E)	495	Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...	Phase 1: October 2007	3G7T	78.8%	Dengue virus		N/A

IDP90779 (show subtarget assignments)	8	cloned	No	YPO3497	16123643	nusA	transcription elongation factor NusA [Ye...	495	Predicted Essential	Community Requests	1K0R	24.4%	Yersinia pestis

IDP00903 (show subtarget assignments)	0	work_stopped	No	STM0123	16763513	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	495	Essential Gene	Phase 2: March 2008	1E8C	91.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90947 (show subtarget assignments)	8	cloned	No	SAR0518	49482744	lysS	lysyl-tRNA synthetase [Staphylococcus au...	495	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3A74	72.1%	Staphylococcus aureus

IDP04215 (show subtarget assignments)	1	cloned	No	STM1574_1_495	16764918	smvA	methyl viologen resistance [Salmonella t...	495	Salmonella essential protein	Phase 4: April 2009	2GFP	17%	Salmonella enterica

IDP00280 (show subtarget assignments)	1	purified	No	AAX48017_51-545	604449	N/A	Envelope (E)	495	Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...	Phase 3: June 2008	3UAJ	79.2%	Dengue virus		N/A

IDP02419 (show subtarget assignments)	1	purified	No	FTT1447c	56708489	manB	phosphomannomutase [Francisella tularens...	494	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2F7L	25.7%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP90565 (show subtarget assignments)	8	soluble	No	VC0162	15640192		ketol-acid reductoisomerase [Vibrio chol...	494	Predicted Essential	Community Requests	1YRL	75.3%	Vibrio cholerae

IDP00686 (show subtarget assignments)	1	purified	No	SACOL2029	57284899	cscA	sucrose-6-phosphate hydrolase	494	Drug Target Function	Phase 2: March 2008	1UYP	29.8%	Staphylococcus aureus	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00665 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1079	57285865	purF	amidophosphoribosyltransferase	494	Drug Target Function	Phase 2: March 2008	1AO0	51%	Staphylococcus aureus	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04075 (show subtarget assignments)	8	selected	No	CAC05807	12329076	icsB	IcsB, function unknown [Shigella flexner...	494	Shigella effector protein	Community Requests			Shigella flexneri

IDP90220 (show subtarget assignments)	8	selected	No	MYXV_gp153	9633785	m150R	m150R	494	ankyrin-like protein, myxoma nuclear factor	Community Requests			Myxoma virus	host range factor	0

IDP01141 (show subtarget assignments)	1	crystallized	No	BA_5155	56404588		Probable cytosol aminopeptidase (Leucine...	494	Drug Target Function	Phase 2: March 2008	3H8E	38.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90429 (show subtarget assignments)	8	cloned	No	CT_860	3329334		hypothetical protein [Chlamydia trachoma...	493	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP91250 (show subtarget assignments)	8	expressed	No	NT01LM1295	16410617	lmo1201	lmo1201 [Listeria monocytogenes]	493	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	24.9%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04149 (show subtarget assignments)	1	expressed	No	YPO3706	115349323		conserved hypothetical protein [Yersinia...	493	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP00788 (show subtarget assignments)	1	crystallized	No	SACOL1043	57284414		glycosyl transferase, group 1 family pro...	493	Conserved Gene / Pathway	Phase 2: March 2008	2JJM	16.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91691 (show subtarget assignments)	8	selected	No	NP_001034438	86788132	EFEMP1	EGF-containing fibulin-like extracellula...	493	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1N7D	19.7%	Homo sapiens

IDP91499 (show subtarget assignments)	8	cloned	No	VP1680	28898454		hypothetical protein VP1680 [Vibrio para...	492	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP90562 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0434	15791801	pgm	phosphoglyceromutase [Campylobacter jeju...	492	Predicted Essential	Community Requests	1EJJ	44%	Campylobacter jejuni

IDP92037 (show subtarget assignments)	8	selected	No	TGME49_033820	237837865		DNA polymerase delta small subunit, puta...	492	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3E0J	27%	Toxoplasma gondii

IDP92030 (show subtarget assignments)	8	selected	No	TGME49_019590	237842827		ruvB-like 1, putative [Toxoplasma gondii...	492	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C9O	55.9%	Toxoplasma gondii

IDP90086 (show subtarget assignments)	8	expressed	No	ZZZ_0002				492	This protein is a component of a type VI secretion system of enteroaggregative E...	Community Requests			Escherichia coli

IDP02364 (show subtarget assignments)	1	cloned	No	Cj0365c	15791732		putative outer membrane channel protein ...	492	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	3PIK	24.8%	Campylobacter jejuni	Cellular processes	Toxin production and resistance

IDP90657 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0556	16120884	murC	UDP-N-acetylmuramate--L-alanine ligase [...	491	Predicted Essential	Community Requests	2F00	86.2%	Yersinia pestis

IDP00906 (show subtarget assignments)	0	work_stopped	No	STM0129	16763519	murC	UDP-N-acetylmuramate--L-alanine ligase	491	Essential Gene	Phase 2: March 2008	2F00	94.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05750 (show subtarget assignments)	1	cloned	No	lmo0237	16802283	gltX	hypothetical protein lmo0237 [Listeria m...	491	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2O5R	43.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP04256 (show subtarget assignments)	1	purified	No	CPF_2006	110801043	spoIVA	stage IV sporulation protein A [Clostrid...	491	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00662 (show subtarget assignments)	1	in_pdb 3KZW	No	SACOL0945	57285819		cytosol aminopeptidase	491	Drug Target Function	Phase 2: March 2008	3KZW	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00016 (show subtarget assignments)	1	crystallized	No	BA_4053	46576983		UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	491	Drug Target Homolog	Phase 1: October 2007	2WTZ	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01996 (show subtarget assignments)	1	in_crystallization_trials	No	STM3136	16766436		putative D-mannonate oxidoreductase [Sal...	490	Conserved; Drug target functions	Phase 3: June 2008	1LJ8	40.6%	Salmonella enterica	Energy metabolism	Other

IDP90207 (show subtarget assignments)	8	soluble	No	MYXV_gp152	9633784	m149R	m149R	490	ankyrin motif, similar to VACV-Cop:B4R	Community Requests	1N11	14.9%	Myxoma virus	host range factor	0

IDP04196
(show subtarget assignments)

1

cloned

No

CPF_2502

110800817

putative lipoprotein [Clostridium perfri...

507

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP90343
(show subtarget assignments)

8

expressed

No

CT148

15604867

mhpA

FAD-dependent monooxygenase [Chlamydia t...

507

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00653
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0451

57286824

ahpF

alkyl hydroperoxide reductase, subunit F...

507

Conserved Gene / Pathway

Phase 2: March 2008

1HYU

53.8%

Staphylococcus aureus

Cellular processes

Detoxification

IDP04331
(show subtarget assignments)

1

purified

No

CPF_2181

110799592

sensor histidine kinase [Clostridium per...

507

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.4%

Clostridium perfringens

Signal transduction

Two-component systems

IDP05495
(show subtarget assignments)

1

cloned

No

CD0237

126697808

fliD

flagellar cap protein [Clostridium diffi...

507

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02591
(show subtarget assignments)

1

crystallized

No

YPO3383

16123532

dgt

deoxyguanosinetriphosphate triphosphohyd...

506

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2PGS

29.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP92103
(show subtarget assignments)

8

selected

No

TGME49_097970

237843837

aspartyl aminopeptidase, putative [Toxop...

506

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3VAR

40.7%

Toxoplasma gondii

IDP05425
(show subtarget assignments)

1

soluble

No

lmo0355

16802400

-

fumarate reductase flavoprotein subunit ...

506

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1D4C

40.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP04554
(show subtarget assignments)

1

cloned

No

STM0791_1_506

16764154

hutH

histidine ammonia-lyase [Salmonella typh...

506

Salmonella essential protein

Phase 4: April 2009

1GK2

76.5%

Salmonella enterica

IDP01452
(show subtarget assignments)

1

soluble

No

VC2400

15642397

murC

UDP-N-acetylmuramate--L-alanine ligase

506

Conserved Gene / Pathway

Phase 2: March 2008

2F00

69.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04475
(show subtarget assignments)

1

cloned

No

YPO2772

115348455

purF

amidophosphoribosyltransferase [Yersinia...

505

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1ECB

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90637
(show subtarget assignments)

8

soluble

No

YPO0888

16121193

lysS

lysyl-tRNA synthetase [Yersinia pestis C...

505

Predicted Essential

Community Requests

1BBU

85.7%

Yersinia pestis

IDP92091
(show subtarget assignments)

8

selected

No

TGME49_014210

237842913

centromere/microtubule binding protein, ...

505

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3U28

49.9%

Toxoplasma gondii

IDP00734
(show subtarget assignments)

1

purified

No

SACOL0841

57284303

pgm

phosphoglyceromutase

505

Drug Target Function

Phase 2: March 2008

1EJJ

62%

Staphylococcus aureus

Energy metabolism

Glycolysis/gluconeogenesis

IDP92032
(show subtarget assignments)

8

selected

No

TGME49_019800

237842869

vacuolar ATP synthase subunit B, putativ...

505

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C61

53.9%

Toxoplasma gondii

IDP00726
(show subtarget assignments)

1

purified

No

SACOL1929

57286276

ABC transporter, ATP-binding protein, pu...

505

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP01218
(show subtarget assignments)

1

expressed

No

BA_3712

73919984

Histidine ammonia-lyase (Histidase)

505

Drug Target Function

Phase 2: March 2008

1GK2

42%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP01173
(show subtarget assignments)

1

cloned

No

BA_1587

30255887

thermostable carboxypeptidase 1

505

Drug Target Function

Phase 2: March 2008

3HQ2

60.8%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91709
(show subtarget assignments)

8

selected

No

NP_006107

5174703

TAB1

TGF-beta-activated kinase 1 and MAP3K7-b...

504

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2J4O

79.6%

Homo sapiens

IDP04344
(show subtarget assignments)

1

in_crystallization_trials

No

VC1004

15641019

amidophosphoribosyltransferase [Vibrio c...

504

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

76.1%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02526
(show subtarget assignments)

1

cloned

No

FTT1600c

56708620

fumA

fumerate hydratase [Francisella tularens...

504

Drug Target

Phase 3: June 2008

2ISB

13.7%

Francisella tularensis

Energy metabolism

TCA cycle

IDP02272
(show subtarget assignments)

1

cloned

No

GBAA2183

47527475

neutral metalloprotease, putative [Bacil...

503

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

1BQB

14.3%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00753
(show subtarget assignments)

1

cloned

No

SACOL0052

57286607

glycosyl transferase, group 1 family pro...

503

Conserved Gene / Pathway

Phase 2: March 2008

2F9F

9.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00161
(show subtarget assignments)

1

soluble

No

VC0835

15640852

tcpT

toxin co-regulated pilus biosynthesis pr...

503

Virulence

Phase 1: October 2007

1P9R

23.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP04709
(show subtarget assignments)

1

cloned

No

YPO0501

115346310

conserved hypothetical protein [Yersinia...

503

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP91004
(show subtarget assignments)

8

soluble

No

y1935

22125827

cysteine desulfurase activator complex s...

503

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

4DN7

18.7%

Yersinia pestis

IDP01197
(show subtarget assignments)

0

work_stopped

No

BA_1389

81715334

D-alanine--poly(phosphoribitol) ligase s...

503

Conserved Gene / Pathway

Phase 2: March 2008

3DHV

99.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02238
(show subtarget assignments)

1

expressed

No

YPO0815

16121126

general secretion pathway protein E [Yer...

503

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

48.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP00834
(show subtarget assignments)

1

expressed

No

SACOL2670

57286574

glycosyl transferase, group 1 family pro...

502

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

10.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02396
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3604

47528890

argH-1

argininosuccinate lyase [Bacillus anthra...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2E9F

27.5%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP01821
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5549

47530869

atpA

F0F1 ATP synthase subunit alpha [Bacillu...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

84.5%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP90685
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0401

15791768

lysS

lysyl-tRNA synthetase [Campylobacter jej...

501

Predicted Essential

Community Requests

1BBU

48.1%

Campylobacter jejuni

IDP91968
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100007436

298255418

zinc-binding lipoprotein AdcA [Streptoco...

501

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2O1E

29.5%

Streptococcus pneumoniae

IDP90196
(show subtarget assignments)

8

cloned

No

AAM13643.1

20153182

CPXV204 CDS

CPXV204 protein

501

kelch-like protein

Community Requests

2VPJ

14%

Cowpox virus

conserved hypothetical proteins

0

IDP01828
(show subtarget assignments)

1

in_pdb
3NZT

Yes

FTT0367c

56707518

gshA

glutamate--cysteine ligase [Francisella ...

501

Drug Target

Phase 3: June 2008

3NZT

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP01496
(show subtarget assignments)

1

soluble

No

VCA0813

15601568

aminopeptidase

501

Drug Target Function

Phase 2: March 2008

1RTQ

43.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91452
(show subtarget assignments)

8

purified

No

VV1_0376

27363845

Type IV secretory pathway, VirD2 compone...

501

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP04407
(show subtarget assignments)

1

cloned

No

CPF_0677

110799553

purH

bifunctional phosphoribosylaminoimidazol...

501

conserved gene; putative drug target function;

Phase 4: April 2009

3ZZM

41.1%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04659
(show subtarget assignments)

1

soluble

No

GBAA0272

47525531

sensor histidine kinase [Bacillus anthra...

501

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP91238
(show subtarget assignments)

8

cloned

No

HP1282

2314448

anthranilate synthase component I (trpE)...

500

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I1Q

46.8%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP04130
(show subtarget assignments)

1

cloned

No

YPO2938

115348602

conserved hypothetical protein [Yersinia...

500

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP91746
(show subtarget assignments)

8

selected

No

Q8BDF8_9POXV

0

500

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

Vaccinia virus

IDP92060
(show subtarget assignments)

8

selected

No

TGME49_063190

237832243

adenylosuccinate lyase, putative [Toxopl...

500

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2PTS

43.2%

Toxoplasma gondii

IDP05177
(show subtarget assignments)

1

cloned

No

BA_2974

30257564

mqo

malate:quinone-oxidoreductase [Bacillus ...

500

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Energy metabolism: TCA cycle

IDP00573
(show subtarget assignments)

1

in_pdb
3GO9

No

YPO3991

16124118

putative insulinase family protease

499

Drug Target Function

Phase 2: March 2008

3GO9

98.6%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02569
(show subtarget assignments)

1

cloned

No

lmo0264

16802310

inlE

internalin E [Listeria monocytogenes EGD...

499

Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815 ; Predicte...

Phase 3: June 2008

1H6U

44.9%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP04043
(show subtarget assignments)

1

soluble

No

VCA0565

15601324

sensor histidine kinase [Vibrio cholerae...

499

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1BXD

6%

Vibrio cholerae

Regulatory functions

Other

IDP00216
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2310

16122534

-

putative carboxypeptidase

499

Virulence

Phase 1: October 2007

3DWC

48.1%

Yersinia pestis

Regulatory functions

Other

IDP05308
(show subtarget assignments)

1

soluble

No

CD3420

126701043

hemD

porphyrin biosynthesis protein [Clostrid...

499

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1PJQ

25.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04576
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0076

49183111

lysyl-tRNA synthetase [Bacillus anthraci...

499

Proposed to be essential proteins

Phase 4: April 2009

3A74

77.6%

Bacillus anthracis

IDP90280
(show subtarget assignments)

8

selected

No

TGME49_004420

211965378

oocyst wall protein COWP, putative [Toxo...

499

Unpublished data from a differentiation mutagenesis screen indicate that the ooc...

Community Requests

1N7D

19%

Toxoplasma gondii

IDP05208
(show subtarget assignments)

1

cloned

No

CD2373

126699988

putative carbon starvation protein [Clos...

499

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP04013
(show subtarget assignments)

1

cloned

No

STM2913_1_498

16766219

putative permease [Salmonella typhimuriu...

498

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP04669
(show subtarget assignments)

1

expressed

No

GBAA1351

47526623

sensor histidine kinase KinD [Bacillus a...

498

putative drug target function;

Phase 4: April 2009

3D36

15.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP00743
(show subtarget assignments)

1

in_pdb
3G25
3GE1

Yes

SACOL1320

57286055

glpK

glycerol kinase

498

Drug Target Function

Phase 2: March 2008

3G25

100%

Staphylococcus aureus

Energy metabolism

Other

IDP01879
(show subtarget assignments)

1

cloned

No

FTT1804c

56708790

rng

ribonuclease G [Francisella tularensis s...

498

Conserved; Drug target functions

Phase 3: June 2008

2BX2

31.9%

Francisella tularensis

Cellular processesTranscription

Cell divisionRNA processing

IDP02443
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0228

16802274

lysS

lysyl-tRNA synthetase [Listeria monocyto...

498

Predicted involvement or location on the cell wall; Drug Target Homologs

Phase 3: June 2008

3A74

69.7%

Listeria monocytogenes

Protein synthesis

tRNA aminoacylation

IDP90802
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3769

16123905

3-octaprenyl-4-hydroxybenzoate decarboxy...

498

Predicted Essential

Community Requests

2IDB

88.2%

Yersinia pestis

IDP04505
(show subtarget assignments)

1

soluble

No

VCA0531

15601291

sensor histidine kinase [Vibrio cholerae...

497

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

15.9%

Vibrio cholerae

Regulatory functions

Other

IDP91482
(show subtarget assignments)

8

expressed

No

VPA0450

28900305

hypothetical protein VPA0450 [Vibrio par...

497

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP01794
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1026

47526305

glpK

glycerol kinase [Bacillus anthracis str....

496

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3G25

75%

Bacillus anthracis

Energy metabolism

Other

IDP01670
(show subtarget assignments)

1

cloned

No

GBAA0156

47525414

hypothetical protein GBAA0156 [Bacillus ...

496

Conserved;

Phase 3: June 2008

2KQ1

6.7%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP00776
(show subtarget assignments)

1

crystallized

No

SACOL0612

57285627

glycosyl transferase, group 1 family pro...

496

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

11.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00699
(show subtarget assignments)

1

in_pdb
3ED6
3FG0

Yes

SACOL2628

57286533

betB

betaine aldehyde dehydrogenase

496

Conserved Gene / Pathway

Phase 2: March 2008

3ED6

100%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP00675
(show subtarget assignments)

1

cloned

No

SACOL1455

57284564

carboxyl-terminal protease

496

Drug Target Function

Phase 2: March 2008

1FC6

20%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91585
(show subtarget assignments)

8

cloned

No

CBU_0635

29541236

hypothetical protein

496

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP04657
(show subtarget assignments)

1

expressed

No

FTT1721c

56708727

purF

amidophosphoribosyltransferase [Francise...

496

conserved gene; putative drug target function;

Phase 4: April 2009

1ECB

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP02462
(show subtarget assignments)

1

expressed

No

FTT1467c

56708507

nadB

L-aspartate oxidase [Francisella tularen...

495

Conserved; Drug target functions

Phase 3: June 2008

1CHU

38.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP00272
(show subtarget assignments)

1

in_pdb
3EGP
3IRC

No

AF180817_281-775

7329982

N/A

Envelope (E)

495

Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...

Phase 1: October 2007

3G7T

78.8%

Dengue virus

N/A

IDP90779
(show subtarget assignments)

8

cloned

No

YPO3497

16123643

nusA

transcription elongation factor NusA [Ye...

495

Predicted Essential

Community Requests

1K0R

24.4%

Yersinia pestis

IDP00903
(show subtarget assignments)

0

work_stopped

No

STM0123

16763513

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

495

Essential Gene

Phase 2: March 2008

1E8C

91.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90947
(show subtarget assignments)

8

cloned

No

SAR0518

49482744

lysS

lysyl-tRNA synthetase [Staphylococcus au...

495

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3A74

72.1%

Staphylococcus aureus

IDP04215
(show subtarget assignments)

1

cloned

No

STM1574_1_495

16764918

smvA

methyl viologen resistance [Salmonella t...

495

Salmonella essential protein

Phase 4: April 2009

2GFP

17%

Salmonella enterica

IDP00280
(show subtarget assignments)

1

purified

No

AAX48017_51-545

604449

N/A

Envelope (E)

495

Contains receptor binding sites and fusogenic domain; also contains 12 Cys resid...

Phase 3: June 2008

3UAJ

79.2%

Dengue virus

N/A

IDP02419
(show subtarget assignments)

1

purified

No

FTT1447c

56708489

manB

phosphomannomutase [Francisella tularens...

494

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2F7L

25.7%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP90565
(show subtarget assignments)

8

soluble

No

VC0162

15640192

ketol-acid reductoisomerase [Vibrio chol...

494

Predicted Essential

Community Requests

1YRL

75.3%

Vibrio cholerae

IDP00686
(show subtarget assignments)

1

purified

No

SACOL2029

57284899

cscA

sucrose-6-phosphate hydrolase

494

Drug Target Function

Phase 2: March 2008

1UYP

29.8%

Staphylococcus aureus

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00665
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1079

57285865

purF

amidophosphoribosyltransferase

494

Drug Target Function

Phase 2: March 2008

1AO0

51%

Staphylococcus aureus

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04075
(show subtarget assignments)

8

selected

No

CAC05807

12329076

icsB

IcsB, function unknown [Shigella flexner...

494

Shigella effector protein

Community Requests

Shigella flexneri

IDP90220
(show subtarget assignments)

8

selected

No

MYXV_gp153

9633785

m150R

494

ankyrin-like protein, myxoma nuclear factor

Community Requests

Myxoma virus

host range factor

0

IDP01141
(show subtarget assignments)

1

crystallized

No

BA_5155

56404588

Probable cytosol aminopeptidase (Leucine...

494

Drug Target Function

Phase 2: March 2008

3H8E

38.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90429
(show subtarget assignments)

8

cloned

No

CT_860

3329334

hypothetical protein [Chlamydia trachoma...

493

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP91250
(show subtarget assignments)

8

expressed

No

NT01LM1295

16410617

lmo1201

lmo1201 [Listeria monocytogenes]

493

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

24.9%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04149
(show subtarget assignments)

1

expressed

No

YPO3706

115349323

conserved hypothetical protein [Yersinia...

493

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP00788
(show subtarget assignments)

1

crystallized

No

SACOL1043

57284414

glycosyl transferase, group 1 family pro...

493

Conserved Gene / Pathway

Phase 2: March 2008

2JJM

16.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91691
(show subtarget assignments)

8

selected

No

NP_001034438

86788132

EFEMP1

EGF-containing fibulin-like extracellula...

493

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1N7D

19.7%

Homo sapiens

IDP91499
(show subtarget assignments)

8

cloned

No

VP1680

28898454

hypothetical protein VP1680 [Vibrio para...

492

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP90562
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0434

15791801

pgm

phosphoglyceromutase [Campylobacter jeju...

492

Predicted Essential

Community Requests

1EJJ

44%

Campylobacter jejuni

IDP92037
(show subtarget assignments)

8

selected

No

TGME49_033820

237837865

DNA polymerase delta small subunit, puta...

492

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3E0J

27%

Toxoplasma gondii

IDP92030
(show subtarget assignments)

8

selected

No

TGME49_019590

237842827

ruvB-like 1, putative [Toxoplasma gondii...

492

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C9O

55.9%

Toxoplasma gondii

IDP90086
(show subtarget assignments)

8

expressed

No

ZZZ_0002

492

This protein is a component of a type VI secretion system of enteroaggregative E...

Community Requests

Escherichia coli

IDP02364
(show subtarget assignments)

1

cloned

No

Cj0365c

15791732

putative outer membrane channel protein ...

492

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

3PIK

24.8%

Campylobacter jejuni

Cellular processes

Toxin production and resistance

IDP90657
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0556

16120884

murC

UDP-N-acetylmuramate--L-alanine ligase [...

491

Predicted Essential

Community Requests

2F00

86.2%

Yersinia pestis

IDP00906
(show subtarget assignments)

0

work_stopped

No

STM0129

16763519

murC

UDP-N-acetylmuramate--L-alanine ligase

491

Essential Gene

Phase 2: March 2008

2F00

94.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05750
(show subtarget assignments)

1

cloned

No

lmo0237

16802283

gltX

hypothetical protein lmo0237 [Listeria m...

491

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2O5R

43.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP04256
(show subtarget assignments)

1

purified

No

CPF_2006

110801043

spoIVA

stage IV sporulation protein A [Clostrid...

491

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00662
(show subtarget assignments)

1

in_pdb
3KZW

No

SACOL0945

57285819

cytosol aminopeptidase

491

Drug Target Function

Phase 2: March 2008

3KZW

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00016
(show subtarget assignments)

1

crystallized

No

BA_4053

46576983

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

491

Drug Target Homolog

Phase 1: October 2007

2WTZ

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01996
(show subtarget assignments)

1

in_crystallization_trials

No

STM3136

16766436

putative D-mannonate oxidoreductase [Sal...

490

Conserved; Drug target functions

Phase 3: June 2008

1LJ8

40.6%

Salmonella enterica

Energy metabolism

Other

IDP90207
(show subtarget assignments)

8

soluble

No

MYXV_gp152

9633784

m149R

490

ankyrin motif, similar to VACV-Cop:B4R

Community Requests

1N11

14.9%

Myxoma virus

host range factor

0