Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91596 (show subtarget assignments)	8	selected	No	AAD02118	4104708	vanXst	D-ala-D-ala dipeptidase [Streptomyces to...	208	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1R44	62%	Streptomyces toyocaensis

IDP91776 (show subtarget assignments)	8	in_crystallization_trials	No	ACM47288	222159815	vanXD	D,D-dipeptidase VanXD [Enterococcus faec...	202	drug resistance / D,D-dipeptidase	Community Requests	1R44	70.3%	Enterococcus faecium

IDP91736 (show subtarget assignments)	8	selected	No	Q51451_PSEAE	0			453	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1R4T	30.7%	Pseudomonas aeruginosa

IDP91748 (show subtarget assignments)	8	selected	No	Q933J5_PSEAE	0			453	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1R4T	30.5%	Pseudomonas aeruginosa

IDP00539 (show subtarget assignments)	1	purified	No	YPO2751	16122955	aroC	chorismate synthase	361	Conserved Gene / Pathway	Phase 2: March 2008	1R52	45%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP91209 (show subtarget assignments)	8	expressed	No	BT_2084	29347494		chorismate synthase [Bacteroides thetaio...	358	potential drug target / Shikimate pathway enzyme	Community Requests	1R52	47.9%	Bacteroides thetaiotaomicron

IDP92110 (show subtarget assignments)	8	selected	No	TGME49_001380	237836313		chorismate synthase, putative [Toxoplasm...	536	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1R52	36.9%	Toxoplasma gondii

IDP91285 (show subtarget assignments)	8	soluble	No	SPA0480	56412719	aroC	chorismate synthase [Salmonella enterica...	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1R52	45.7%	Salmonella enterica

IDP91165 (show subtarget assignments)	8	cloned	No	VC_2116	12229712	aroC	RecName: Full=Chorismate synthase; AltNa...	361	potential drug target / Shikimate pathway enzyme	Community Requests	1R52	46.1%	Vibrio cholerae

IDP00315 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0874	29654200	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1R52	44.7%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP04437 (show subtarget assignments)	1	cloned	No	YPO0023	115345855	glnR	Two component regulatory protein involve...	349	putative drug target function;	Phase 4: April 2009	1R62	38.4%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP91172 (show subtarget assignments)	8	purified	No	PA1706	15596903	pcrV	type III secretion protein PcrV [Pseudom...	294	potential drug target / P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...	Community Requests	1R6F	35.4%	Pseudomonas aeruginosa

IDP91311 (show subtarget assignments)	8	purified	No	VP1659	28898433		hypothetical protein VP1659 [Vibrio para...	607	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1R6F	12.8%	Vibrio parahaemolyticus

IDP00267 (show subtarget assignments)	1	cloned	No	AAX48017_4-113	61652905	N/A	Capsid protein (C)	111	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.4%	Dengue virus	Unclassified	N/A

IDP00263 (show subtarget assignments)	1	cloned	No	AF180817_1-114	7329982	N/A	Capsid protein (C)	114	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.5%	Dengue virus	Unclassified	N/A

IDP00277 (show subtarget assignments)	1	cloned	No	AAA99437_5-114	323469	N/A	Capsid protein (C)	110	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	57.3%	Dengue virus	Unclassified	N/A

IDP04587 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0118	49183152		50S ribosomal protein L29 [Bacillus anth...	66	Proposed to be essential proteins	Phase 4: April 2009	1R73	45.5%	Bacillus anthracis

IDP91812 (show subtarget assignments)	8	soluble	No	b0823	1787044	ybiW	predicted pyruvate formate lyase [Escher...	810	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1R8W	37.1%	Escherichia coli

IDP05541 (show subtarget assignments)	1	cloned	No	CD3437	126701060	cobS	cobalamin synthase [Clostridium difficil...	257	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RH5	23.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90693 (show subtarget assignments)	8	purified	No	Cj1599	15792904	hisB	imidazole glycerol-phosphate dehydratase...	352	Predicted Essential	Community Requests	1RHY	25.6%	Campylobacter jejuni

IDP05710 (show subtarget assignments)	1	cloned	No	SACOL1673	57650500	alaS	alanyl-tRNA synthetase [Staphylococcus a...	876	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RIQ	25.9%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP04730 (show subtarget assignments)	1	cloned	No	BAS4284	49187280		alanyl-tRNA synthetase [Bacillus anthrac...	880	Proposed to be essential proteins	Phase 4: April 2009	1RIQ	26.3%	Bacillus anthracis

IDP05327 (show subtarget assignments)	1	cloned	No	lmo1504	16803544	alaS	alanyl-tRNA synthetase [Listeria monocyt...	879	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RIQ	25.8%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP00948 (show subtarget assignments)	1	expressed	No	STM1060	16764419		putative iron-sulfur protein	369	Conserved Gene / Pathway	Phase 2: March 2008	1ROE	8.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP02557 (show subtarget assignments)	1	purified	No	Cj0061c	15791453	fliA	flagellar biosynthesis sigma factor [Cam...	238	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1RP3	35.3%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP05057 (show subtarget assignments)	1	cloned	No	CD0266	126697838	fliA	RNA polymerase sigma factor for flagella...	233	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	38.2%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05283 (show subtarget assignments)	1	soluble	No	CD0229	126697800	flgM	negative regulator of flagellin synthesi...	91	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	27.5%	Clostridium difficile	Regulatory functions: DNA interactions

IDP04267 (show subtarget assignments)	1	cloned	No	CPF_2134	110799922	spoVD	stage V sporulation protein D [Clostridi...	727	conserved gene; putative drug target function;	Phase 4: April 2009	1RP5	26.1%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP00344 (show subtarget assignments)	1	cloned	No	lmo2039	16804078	pbpB	hypothetical protein lmo2039	751	Drug Target Function	Phase 2: March 2008	1RP5	34.1%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90710 (show subtarget assignments)	8	crystallized	No	Cj0451	15791815	rep	ribulose-phosphate 3-epimerase [Campylob...	215	Predicted Essential	Community Requests	1RPX	48.4%	Campylobacter jejuni

IDP01605 (show subtarget assignments)	1	soluble	No	GBAA4560	47529856		hypothetical protein GBAA4560 [Bacillus ...	97	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1RQ8	67%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP05147 (show subtarget assignments)	1	cloned	No	BAS4903	49187891	-	methionyl-tRNA synthetase [Bacillus anth...	544	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1RQG	38.7%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP01073 (show subtarget assignments)	1	purified	No	STM4044	16767310		putative alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	42.6%	Salmonella enterica	Energy metabolism	Fermentation

IDP01042 (show subtarget assignments)	1	in_crystallization_trials	No	STM2973	16766278	fucO	L-1,2-propanediol oxidoreductase	382	Conserved Gene / Pathway	Phase 2: March 2008	1RRM	91.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP01824 (show subtarget assignments)	1	cloned	No	STM3197	16766497	glgS	glycogen synthesis protein GlgS [Salmone...	69	Conserved; Drug target functions	Phase 3: June 2008	1RRZ	73.9%	Salmonella enterica	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01496 (show subtarget assignments)	1	soluble	No	VCA0813	15601568		aminopeptidase	501	Drug Target Function	Phase 2: March 2008	1RTQ	43.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04298 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0827	15601582	phhB	pterin-4-alpha-carbinolamine dehydratase...	109	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1RU0	33%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP02261 (show subtarget assignments)	1	expressed	No	GBAA2516	47527804	fba-1	fructose-bisphosphate aldolase [Bacillus...	281	Essential; Drug target functions	Phase 3: June 2008	1RV8	41.2%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP02530 (show subtarget assignments)	1	soluble	No	FTT1674	56708684	ribH	riboflavin synthase beta subunit (6,7-di...	147	Conserved; Drug target functions	Phase 3: June 2008	1RVV	45.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05516 (show subtarget assignments)	1	soluble	No	CD1697	126699303	ribH	riboflavin synthase beta chain (6,7-dime...	158	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RVV	66.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00401 (show subtarget assignments)	1	cloned	No	YPO2490	161486873		putative hemolysin	2531	Virulence Associated Factor	Phase 2: March 2008	1RWR	3.9%	Yersinia pestis	Viral functions	General

IDP92022 (show subtarget assignments)	8	selected	No	TGME49_009160	237840757		glycylpeptide N-tetradecanoyltransferase...	448	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1RXT	48.9%	Toxoplasma gondii

IDP91383 (show subtarget assignments)	8	soluble	No	VV1_1467	27364851		arginine deiminase [Vibrio vulnificus CM...	406	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1RXX	45.3%	Vibrio vulnificus

IDP02804 (show subtarget assignments)	1	cloned	No	lmo2181	16804220		hypothetical protein lmo2181 [Listeria m...	246	Known virulence-Surface protein anchoring; Predicted virulence-Iron Scavenging M...	Phase 3: June 2008	1RZ2	46.2%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP92004 (show subtarget assignments)	8	selected	No	SpneCM_010100007049	298255341		sortase, SrtB family protein [Streptococ...	332	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1RZ2	26.2%	Streptococcus pneumoniae

IDP90164 (show subtarget assignments)	8	purified	No	CD1832	122973876		Putative chorismate biosynthesis-related...	337	Potential drug target. Shikimate pathway enzyme	Community Requests	1RZM	47.2%	Clostridium difficile

IDP90817 (show subtarget assignments)	8	cloned	No	VC2431	15642428		DNA topoisomerase IV subunit B [Vibrio c...	626	Predicted Essential	Community Requests	1S16	49.8%	Vibrio cholerae

IDP00154 (show subtarget assignments)	1	crystallized	No	VC2448	15642444	pyrG	CTP synthase	545	Essential	Phase 1: October 2007	1S1M	79.5%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP01868 (show subtarget assignments)	1	cloned	No	GBAA5583	47530904	ctrA	CTP synthetase [Bacillus anthracis str. ...	535	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1S1M	56.1%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00074 (show subtarget assignments)	0	work_stopped	No	NT01ST3685	16421504	pyrG	CTP synthetase	545	Essential	Phase 1: October 2007	1S1M	95%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01361 (show subtarget assignments)	1	expressed	No	VC0157	15640187		alkaline serine protease	535	Drug Target Function	Phase 2: March 2008	1S2N	35.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91922 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100006235	298255189		pneumolysin (Thiol-activated cytolysin) ...	471	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1S3R	53.3%	Streptococcus pneumoniae

IDP91923 (show subtarget assignments)	8	purified	No	SpneCM_010100002081	298254388		hypothetical protein SpneCM_02081 [Strep...	170	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1S3R	31.2%	Streptococcus pneumoniae

IDP04153 (show subtarget assignments)	1	cloned	No	YPO3975	218930970	opdA	oligopeptidase A [Yersinia pestis CO92]	680	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1S4B	30.7%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00498 (show subtarget assignments)	1	cloned	No	YPO0166	16120509		putative glycosyl hydrolase	437	Drug Target Function	Phase 2: March 2008	1S6Y	52.6%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP91830 (show subtarget assignments)	8	soluble	No	b1779	1788079	gapA	glyceraldehyde-3-phosphate dehydrogenase...	331	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1S7C	100%	Escherichia coli

IDP90539 (show subtarget assignments)	8	crystallized	No	VC2708	15642702	gmk	guanylate kinase [Vibrio cholerae O1 bio...	229	Predicted Essential	Community Requests	1S96	59.8%	Vibrio cholerae

IDP90623 (show subtarget assignments)	8	purified	No	Cj1177c	15792501	gmk	guanylate kinase [Campylobacter jejuni s...	207	Predicted Essential	Community Requests	1S96	39.1%	Campylobacter jejuni

IDP01698 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3359	16123509	truD	tRNA pseudouridine synthase D [Yersinia ...	349	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1SB7	64.5%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00650 (show subtarget assignments)	1	soluble	No	SACOL0113	57286662		NAD-dependent epimerase/dehydratase fami...	323	Conserved Gene / Pathway	Phase 2: March 2008	1SB8	36.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01383 (show subtarget assignments)	1	in_crystallization_trials	No	VC0538	15640560		thiosulfate ABC transporter, periplasmic...	333	Conserved Gene / Pathway	Phase 2: March 2008	1SBP	42.3%	Vibrio cholerae	Transport and binding proteins	Anions

IDP04476 (show subtarget assignments)	1	cloned	No	YPO2773	115348456	ubiX	probable 3-octaprenyl-4-hydroxybenzoate ...	190	conserved gene; putative drug target function;	Phase 4: April 2009	1SBZ	51.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP00113 (show subtarget assignments)	0	work_stopped	No	NT01SAA0015	16119212	blaI	PENICILLINASE REPRESSOR	126	Virulence	Phase 1: October 2007	1SD4	100%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP04106 (show subtarget assignments)	1	cloned	No	BAS0124	49183158		30S ribosomal protein S8 [Bacillus anthr...	132	Proposed to be essential proteins	Phase 4: April 2009	1SEI	85.6%	Bacillus anthracis

IDP01016 (show subtarget assignments)	1	cloned	No	STM2792	16766103	gabT	4-aminobutyrate aminotransferase	427	Conserved Gene / Pathway	Phase 2: March 2008	1SF2	88.3%	Salmonella enterica	Central intermediary metabolism	Other

IDP02716 (show subtarget assignments)	1	cloned	No	GBAA0325	47525592	gabT	4-aminobutyrate aminotransferase [Bacill...	454	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SF2	45.2%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01825 (show subtarget assignments)	1	cloned	No	STM2265	16765593	ada	O6-methylguanine-DNA methyltransferase/t...	353	Conserved; Drug target functions	Phase 3: June 2008	1SFE	37.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02832 (show subtarget assignments)	1	expressed	No	FTT1518	56708554	ogt	methylated-DNA--protein-cysteine methylt...	190	Conserved; Drug target functions	Phase 3: June 2008	1SFE	28.9%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy	Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP02240 (show subtarget assignments)	1	cloned	No	FTT1572c	56708598	ompH	outer membrane protein OmpH [Francisella...	167	Drug Target	Phase 3: June 2008	1SG2	23.4%	Francisella tularensis	Cell envelopeMobile and extrachromosomal element functions	OtherProphage functions

IDP01310 (show subtarget assignments)	1	purified	No	VC2251	15642249		outer membrane protein OmpH	169	Conserved Gene / Pathway	Phase 2: March 2008	1SG2	30.2%	Vibrio cholerae	Cell envelope	Other

IDP00859 (show subtarget assignments)	1	soluble	No	STM1770	16765111	chaB	cation transport regulator	76	Conserved Gene / Pathway	Phase 2: March 2008	1SG7	81.6%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP00856 (show subtarget assignments)	1	purified	No	STM0388	16763768	aroL	shikimate kinase II	181	Conserved Gene / Pathway	Phase 2: March 2008	1SHK	48.6%	Salmonella enterica	Amino acid biosynthesis	Aromatic amino acid family

IDP91670 (show subtarget assignments)	8	selected	No	ANTR2_HUMAN	0			489	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SHU	37%	Homo sapiens

IDP91692 (show subtarget assignments)	8	selected	No	NP_001093	4501891	ACTN1	alpha-actinin-1 isoform b [Homo sapiens]...	892	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SJJ	93.3%	Homo sapiens

IDP01832 (show subtarget assignments)	1	expressed	No	GBAA5547	47530867	atpD	F0F1 ATP synthase subunit beta [Bacillus...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	86.4%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP01821 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5549	47530869	atpA	F0F1 ATP synthase subunit alpha [Bacillu...	502	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	84.5%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP02802 (show subtarget assignments)	1	cloned	No	GBAA3471	47528757		short chain dehydrogenase/reductase fami...	234	Conserved; Essential;	Phase 3: June 2008	1SNY	26.8%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP91542 (show subtarget assignments)	8	selected	No	TGME49_080410	237844275		3',5'-cyclic phosphodiesterase, putative...	1085	potential drug target / Phosphodiesterases are key regulators of cell signalling pathways and are attrac...	Community Requests	1SO2	11.2%	Toxoplasma gondii

IDP02413 (show subtarget assignments)	1	cloned	No	YPO3568	16123712	degS	serine endoprotease [Yersinia pestis CO9...	362	Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...	Phase 3: June 2008	1SOT	63%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01386 (show subtarget assignments)	1	soluble	No	VC0565	15640587		protease DegS	352	Drug Target Function	Phase 2: March 2008	1SOT	47.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91758 (show subtarget assignments)	8	selected	No	VWF_HUMAN	0			2813	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SQ0	7.5%	Homo sapiens

IDP91230 (show subtarget assignments)	8	soluble	No	NT04EC2956	26109123	aroC	Chorismate synthase [Escherichia coli CF...	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1SQ1	46.5%	Escherichia coli	Amino acid biosynthesis: Aromatic amino acid family

IDP91284 (show subtarget assignments)	8	cloned	No	SF2405	56480091	aroC	chorismate synthase [Shigella flexneri 2...	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1SQ1	46.3%	Shigella flexneri

IDP91303 (show subtarget assignments)	8	soluble	No	STM2384	16765711	aroC	chorismate synthase	361	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1SQ1	45.7%	Salmonella enterica

IDP00327 (show subtarget assignments)	0	work_stopped	No	Cj1634c	15792939	aroC	chorismate synthase	362	Drug Target Function	Phase 2: March 2008	1SQ1	100%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02691 (show subtarget assignments)	1	purified	No	FTT0943c	56708040	folB	dihydroneopterin aldolase [Francisella t...	117	Drug Target	Phase 3: June 2008	1SQL	28.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01033 (show subtarget assignments)	1	soluble	No	STM3815	16767100	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00993 (show subtarget assignments)	0	work_stopped	No	STM2250	16765578	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02292 (show subtarget assignments)	1	expressed	No	Cj0078c	15791468	cdtB	cytolethal distending toxin [Campylobact...	265	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008	1SR4	50.9%	Campylobacter jejuni	Cellular processes	Pathogenesis

IDP02306 (show subtarget assignments)	1	cloned	No	Cj0079c	15791469	cdtA	cytolethal distending toxin [Campylobact...	268	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008	1SR4	24.3%	Campylobacter jejuni	Cellular processes	Pathogenesis

IDP05271 (show subtarget assignments)	1	cloned	No	lmo1194	16803234	cbiD	cobalt-precorrin-6A synthase [Listeria m...	373	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1SR8	23.1%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91684 (show subtarget assignments)	8	selected	No	NCAP_CVHSA	0			422	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SSK	32.9%	SARS coronavirus

IDP02290 (show subtarget assignments)	1	expressed	No	GBAA3674	47528959		ahpC/TSA family protein [Bacillus anthra...	191	Drug target motif; Involved in sporulation;	Phase 3: June 2008	1ST9	29.8%	Bacillus anthracis	Unknown function	General

IDP02734 (show subtarget assignments)	1	cloned	No	GBAA1779	47527069		thioredoxin family protein [Bacillus ant...	184	Drug target motif; Drug target functions	Phase 3: June 2008	1ST9	27.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02519 (show subtarget assignments)	1	cloned	No	GBAA1494	47526768	resA	thiol-disulfide oxidoreductase [Bacillus...	173	Conserved; Drug target functions	Phase 3: June 2008	1ST9	41.6%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02375 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4701	47530000	engB	GTPase EngB [Bacillus anthracis str. 'Am...	198	Conserved; Essential;	Phase 3: June 2008	1SUL	72.2%	Bacillus anthracis	Unknown function	General

IDP00257 (show subtarget assignments)	1	in_crystallization_trials	No	MODVgp1	20177456		Modoc virus Envelope protein	393	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1SVB	41%	Modoc virus

IDP02326 (show subtarget assignments)	1	purified	No	FTT0976	56708068	trxA2	thioredoxin [Francisella tularensis subs...	108	Drug Target	Phase 3: June 2008	1SYR	41.7%	Francisella tularensis	Energy metabolism	Electron transport

IDP02807 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4705	47530004	tig	trigger factor [Bacillus anthracis str. ...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T11	32.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP91596
(show subtarget assignments)

8

selected

No

AAD02118

4104708

vanXst

D-ala-D-ala dipeptidase [Streptomyces to...

208

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1R44

62%

Streptomyces toyocaensis

IDP91776
(show subtarget assignments)

8

in_crystallization_trials

No

ACM47288

222159815

vanXD

D,D-dipeptidase VanXD [Enterococcus faec...

202

drug resistance / D,D-dipeptidase

Community Requests

1R44

70.3%

Enterococcus faecium

IDP91736
(show subtarget assignments)

8

selected

No

Q51451_PSEAE

0

453

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1R4T

30.7%

Pseudomonas aeruginosa

IDP91748
(show subtarget assignments)

8

selected

No

Q933J5_PSEAE

0

453

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1R4T

30.5%

Pseudomonas aeruginosa

IDP00539
(show subtarget assignments)

1

purified

No

YPO2751

16122955

aroC

chorismate synthase

361

Conserved Gene / Pathway

Phase 2: March 2008

1R52

45%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP91209
(show subtarget assignments)

8

expressed

No

BT_2084

29347494

chorismate synthase [Bacteroides thetaio...

358

potential drug target / Shikimate pathway enzyme

Community Requests

1R52

47.9%

Bacteroides thetaiotaomicron

IDP92110
(show subtarget assignments)

8

selected

No

TGME49_001380

237836313

chorismate synthase, putative [Toxoplasm...

536

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1R52

36.9%

Toxoplasma gondii

IDP91285
(show subtarget assignments)

8

soluble

No

SPA0480

56412719

aroC

chorismate synthase [Salmonella enterica...

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1R52

45.7%

Salmonella enterica

IDP91165
(show subtarget assignments)

8

cloned

No

VC_2116

12229712

aroC

RecName: Full=Chorismate synthase; AltNa...

361

potential drug target / Shikimate pathway enzyme

Community Requests

1R52

46.1%

Vibrio cholerae

IDP00315
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0874

29654200

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1R52

44.7%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP04437
(show subtarget assignments)

1

cloned

No

YPO0023

115345855

glnR

Two component regulatory protein involve...

349

putative drug target function;

Phase 4: April 2009

1R62

38.4%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP91172
(show subtarget assignments)

8

purified

No

PA1706

15596903

pcrV

type III secretion protein PcrV [Pseudom...

294

potential drug target / P. aeruginosa is an important clinical pathogen. PcrV is a critical component (t...

Community Requests

1R6F

35.4%

Pseudomonas aeruginosa

IDP91311
(show subtarget assignments)

8

purified

No

VP1659

28898433

hypothetical protein VP1659 [Vibrio para...

607

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1R6F

12.8%

Vibrio parahaemolyticus

IDP00267
(show subtarget assignments)

1

cloned

No

AAX48017_4-113

61652905

N/A

Capsid protein (C)

111

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.4%

Dengue virus

Unclassified

N/A

IDP00263
(show subtarget assignments)

1

cloned

No

AF180817_1-114

7329982

N/A

Capsid protein (C)

114

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.5%

Dengue virus

Unclassified

N/A

IDP00277
(show subtarget assignments)

1

cloned

No

AAA99437_5-114

323469

N/A

Capsid protein (C)

110

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

57.3%

Dengue virus

Unclassified

N/A

IDP04587
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0118

49183152

50S ribosomal protein L29 [Bacillus anth...

66

Proposed to be essential proteins

Phase 4: April 2009

1R73

45.5%

Bacillus anthracis

IDP91812
(show subtarget assignments)

8

soluble

No

b0823

1787044

ybiW

predicted pyruvate formate lyase [Escher...

810

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1R8W

37.1%

Escherichia coli

IDP05541
(show subtarget assignments)

1

cloned

No

CD3437

126701060

cobS

cobalamin synthase [Clostridium difficil...

257

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RH5

23.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90693
(show subtarget assignments)

8

purified

No

Cj1599

15792904

hisB

imidazole glycerol-phosphate dehydratase...

352

Predicted Essential

Community Requests

1RHY

25.6%

Campylobacter jejuni

IDP05710
(show subtarget assignments)

1

cloned

No

SACOL1673

57650500

alaS

alanyl-tRNA synthetase [Staphylococcus a...

876

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RIQ

25.9%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP04730
(show subtarget assignments)

1

cloned

No

BAS4284

49187280

alanyl-tRNA synthetase [Bacillus anthrac...

880

Proposed to be essential proteins

Phase 4: April 2009

1RIQ

26.3%

Bacillus anthracis

IDP05327
(show subtarget assignments)

1

cloned

No

lmo1504

16803544

alaS

alanyl-tRNA synthetase [Listeria monocyt...

879

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RIQ

25.8%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP00948
(show subtarget assignments)

1

expressed

No

STM1060

16764419

putative iron-sulfur protein

369

Conserved Gene / Pathway

Phase 2: March 2008

1ROE

8.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP02557
(show subtarget assignments)

1

purified

No

Cj0061c

15791453

fliA

flagellar biosynthesis sigma factor [Cam...

238

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1RP3

35.3%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP05057
(show subtarget assignments)

1

cloned

No

CD0266

126697838

fliA

RNA polymerase sigma factor for flagella...

233

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

38.2%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05283
(show subtarget assignments)

1

soluble

No

CD0229

126697800

flgM

negative regulator of flagellin synthesi...

91

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

27.5%

Clostridium difficile

Regulatory functions: DNA interactions

IDP04267
(show subtarget assignments)

1

cloned

No

CPF_2134

110799922

spoVD

stage V sporulation protein D [Clostridi...

727

conserved gene; putative drug target function;

Phase 4: April 2009

1RP5

26.1%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP00344
(show subtarget assignments)

1

cloned

No

lmo2039

16804078

pbpB

hypothetical protein lmo2039

751

Drug Target Function

Phase 2: March 2008

1RP5

34.1%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90710
(show subtarget assignments)

8

crystallized

No

Cj0451

15791815

rep

ribulose-phosphate 3-epimerase [Campylob...

215

Predicted Essential

Community Requests

1RPX

48.4%

Campylobacter jejuni

IDP01605
(show subtarget assignments)

1

soluble

No

GBAA4560

47529856

hypothetical protein GBAA4560 [Bacillus ...

97

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1RQ8

67%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP05147
(show subtarget assignments)

1

cloned

No

BAS4903

49187891

-

methionyl-tRNA synthetase [Bacillus anth...

544

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1RQG

38.7%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP01073
(show subtarget assignments)

1

purified

No

STM4044

16767310

putative alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

42.6%

Salmonella enterica

Energy metabolism

Fermentation

IDP01042
(show subtarget assignments)

1

in_crystallization_trials

No

STM2973

16766278

fucO

L-1,2-propanediol oxidoreductase

382

Conserved Gene / Pathway

Phase 2: March 2008

1RRM

91.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP01824
(show subtarget assignments)

1

cloned

No

STM3197

16766497

glgS

glycogen synthesis protein GlgS [Salmone...

69

Conserved; Drug target functions

Phase 3: June 2008

1RRZ

73.9%

Salmonella enterica

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01496
(show subtarget assignments)

1

soluble

No

VCA0813

15601568

aminopeptidase

501

Drug Target Function

Phase 2: March 2008

1RTQ

43.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04298
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0827

15601582

phhB

pterin-4-alpha-carbinolamine dehydratase...

109

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1RU0

33%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP02261
(show subtarget assignments)

1

expressed

No

GBAA2516

47527804

fba-1

fructose-bisphosphate aldolase [Bacillus...

281

Essential; Drug target functions

Phase 3: June 2008

1RV8

41.2%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP02530
(show subtarget assignments)

1

soluble

No

FTT1674

56708684

ribH

riboflavin synthase beta subunit (6,7-di...

147

Conserved; Drug target functions

Phase 3: June 2008

1RVV

45.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05516
(show subtarget assignments)

1

soluble

No

CD1697

126699303

ribH

riboflavin synthase beta chain (6,7-dime...

158

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RVV

66.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00401
(show subtarget assignments)

1

cloned

No

YPO2490

161486873

putative hemolysin

2531

Virulence Associated Factor

Phase 2: March 2008

1RWR

3.9%

Yersinia pestis

Viral functions

General

IDP92022
(show subtarget assignments)

8

selected

No

TGME49_009160

237840757

glycylpeptide N-tetradecanoyltransferase...

448

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1RXT

48.9%

Toxoplasma gondii

IDP91383
(show subtarget assignments)

8

soluble

No

VV1_1467

27364851

arginine deiminase [Vibrio vulnificus CM...

406

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1RXX

45.3%

Vibrio vulnificus

IDP02804
(show subtarget assignments)

1

cloned

No

lmo2181

16804220

hypothetical protein lmo2181 [Listeria m...

246

Known virulence-Surface protein anchoring; Predicted virulence-Iron Scavenging M...

Phase 3: June 2008

1RZ2

46.2%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP92004
(show subtarget assignments)

8

selected

No

SpneCM_010100007049

298255341

sortase, SrtB family protein [Streptococ...

332

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1RZ2

26.2%

Streptococcus pneumoniae

IDP90164
(show subtarget assignments)

8

purified

No

CD1832

122973876

Putative chorismate biosynthesis-related...

337

Potential drug target. Shikimate pathway enzyme

Community Requests

1RZM

47.2%

Clostridium difficile

IDP90817
(show subtarget assignments)

8

cloned

No

VC2431

15642428

DNA topoisomerase IV subunit B [Vibrio c...

626

Predicted Essential

Community Requests

1S16

49.8%

Vibrio cholerae

IDP00154
(show subtarget assignments)

1

crystallized

No

VC2448

15642444

pyrG

CTP synthase

545

Essential

Phase 1: October 2007

1S1M

79.5%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP01868
(show subtarget assignments)

1

cloned

No

GBAA5583

47530904

ctrA

CTP synthetase [Bacillus anthracis str. ...

535

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1S1M

56.1%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00074
(show subtarget assignments)

0

work_stopped

No

NT01ST3685

16421504

pyrG

CTP synthetase

545

Essential

Phase 1: October 2007

1S1M

95%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01361
(show subtarget assignments)

1

expressed

No

VC0157

15640187

alkaline serine protease

535

Drug Target Function

Phase 2: March 2008

1S2N

35.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91922
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100006235

298255189

pneumolysin (Thiol-activated cytolysin) ...

471

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1S3R

53.3%

Streptococcus pneumoniae

IDP91923
(show subtarget assignments)

8

purified

No

SpneCM_010100002081

298254388

hypothetical protein SpneCM_02081 [Strep...

170

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1S3R

31.2%

Streptococcus pneumoniae

IDP04153
(show subtarget assignments)

1

cloned

No

YPO3975

218930970

opdA

oligopeptidase A [Yersinia pestis CO92]

680

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1S4B

30.7%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00498
(show subtarget assignments)

1

cloned

No

YPO0166

16120509

putative glycosyl hydrolase

437

Drug Target Function

Phase 2: March 2008

1S6Y

52.6%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP91830
(show subtarget assignments)

8

soluble

No

b1779

1788079

gapA

glyceraldehyde-3-phosphate dehydrogenase...

331

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1S7C

100%

Escherichia coli

IDP90539
(show subtarget assignments)

8

crystallized

No

VC2708

15642702

gmk

guanylate kinase [Vibrio cholerae O1 bio...

229

Predicted Essential

Community Requests

1S96

59.8%

Vibrio cholerae

IDP90623
(show subtarget assignments)

8

purified

No

Cj1177c

15792501

gmk

guanylate kinase [Campylobacter jejuni s...

207

Predicted Essential

Community Requests

1S96

39.1%

Campylobacter jejuni

IDP01698
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3359

16123509

truD

tRNA pseudouridine synthase D [Yersinia ...

349

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1SB7

64.5%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00650
(show subtarget assignments)

1

soluble

No

SACOL0113

57286662

NAD-dependent epimerase/dehydratase fami...

323

Conserved Gene / Pathway

Phase 2: March 2008

1SB8

36.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01383
(show subtarget assignments)

1

in_crystallization_trials

No

VC0538

15640560

thiosulfate ABC transporter, periplasmic...

333

Conserved Gene / Pathway

Phase 2: March 2008

1SBP

42.3%

Vibrio cholerae

Transport and binding proteins

Anions

IDP04476
(show subtarget assignments)

1

cloned

No

YPO2773

115348456

ubiX

probable 3-octaprenyl-4-hydroxybenzoate ...

190

conserved gene; putative drug target function;

Phase 4: April 2009

1SBZ

51.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP00113
(show subtarget assignments)

0

work_stopped

No

NT01SAA0015

16119212

blaI

PENICILLINASE REPRESSOR

126

Virulence

Phase 1: October 2007

1SD4

100%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP04106
(show subtarget assignments)

1

cloned

No

BAS0124

49183158

30S ribosomal protein S8 [Bacillus anthr...

132

Proposed to be essential proteins

Phase 4: April 2009

1SEI

85.6%

Bacillus anthracis

IDP01016
(show subtarget assignments)

1

cloned

No

STM2792

16766103

gabT

4-aminobutyrate aminotransferase

427

Conserved Gene / Pathway

Phase 2: March 2008

1SF2

88.3%

Salmonella enterica

Central intermediary metabolism

Other

IDP02716
(show subtarget assignments)

1

cloned

No

GBAA0325

47525592

gabT

4-aminobutyrate aminotransferase [Bacill...

454

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SF2

45.2%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01825
(show subtarget assignments)

1

cloned

No

STM2265

16765593

ada

O6-methylguanine-DNA methyltransferase/t...

353

Conserved; Drug target functions

Phase 3: June 2008

1SFE

37.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02832
(show subtarget assignments)

1

expressed

No

FTT1518

56708554

ogt

methylated-DNA--protein-cysteine methylt...

190

Conserved; Drug target functions

Phase 3: June 2008

1SFE

28.9%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy

Heme, porphyrin, and cobalaminOther,tRNA and rRNA base modification

IDP02240
(show subtarget assignments)

1

cloned

No

FTT1572c

56708598

ompH

outer membrane protein OmpH [Francisella...

167

Drug Target

Phase 3: June 2008

1SG2

23.4%

Francisella tularensis

Cell envelopeMobile and extrachromosomal element functions

OtherProphage functions

IDP01310
(show subtarget assignments)

1

purified

No

VC2251

15642249

outer membrane protein OmpH

169

Conserved Gene / Pathway

Phase 2: March 2008

1SG2

30.2%

Vibrio cholerae

Cell envelope

Other

IDP00859
(show subtarget assignments)

1

soluble

No

STM1770

16765111

chaB

cation transport regulator

76

Conserved Gene / Pathway

Phase 2: March 2008

1SG7

81.6%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP00856
(show subtarget assignments)

1

purified

No

STM0388

16763768

aroL

shikimate kinase II

181

Conserved Gene / Pathway

Phase 2: March 2008

1SHK

48.6%

Salmonella enterica

Amino acid biosynthesis

Aromatic amino acid family

IDP91670
(show subtarget assignments)

8

selected

No

ANTR2_HUMAN

0

489

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SHU

37%

Homo sapiens

IDP91692
(show subtarget assignments)

8

selected

No

NP_001093

4501891

ACTN1

alpha-actinin-1 isoform b [Homo sapiens]...

892

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SJJ

93.3%

Homo sapiens

IDP01832
(show subtarget assignments)

1

expressed

No

GBAA5547

47530867

atpD

F0F1 ATP synthase subunit beta [Bacillus...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

86.4%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP01821
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5549

47530869

atpA

F0F1 ATP synthase subunit alpha [Bacillu...

502

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

84.5%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP02802
(show subtarget assignments)

1

cloned

No

GBAA3471

47528757

short chain dehydrogenase/reductase fami...

234

Conserved; Essential;

Phase 3: June 2008

1SNY

26.8%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP91542
(show subtarget assignments)

8

selected

No

TGME49_080410

237844275

3',5'-cyclic phosphodiesterase, putative...

1085

potential drug target / Phosphodiesterases are key regulators of cell signalling pathways and are attrac...

Community Requests

1SO2

11.2%

Toxoplasma gondii

IDP02413
(show subtarget assignments)

1

cloned

No

YPO3568

16123712

degS

serine endoprotease [Yersinia pestis CO9...

362

Drug target motif; Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmi...

Phase 3: June 2008

1SOT

63%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01386
(show subtarget assignments)

1

soluble

No

VC0565

15640587

protease DegS

352

Drug Target Function

Phase 2: March 2008

1SOT

47.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91758
(show subtarget assignments)

8

selected

No

VWF_HUMAN

0

2813

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SQ0

7.5%

Homo sapiens

IDP91230
(show subtarget assignments)

8

soluble

No

NT04EC2956

26109123

aroC

Chorismate synthase [Escherichia coli CF...

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1SQ1

46.5%

Escherichia coli

Amino acid biosynthesis: Aromatic amino acid family

IDP91284
(show subtarget assignments)

8

cloned

No

SF2405

56480091

aroC

chorismate synthase [Shigella flexneri 2...

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1SQ1

46.3%

Shigella flexneri

IDP91303
(show subtarget assignments)

8

soluble

No

STM2384

16765711

aroC

chorismate synthase

361

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1SQ1

45.7%

Salmonella enterica

IDP00327
(show subtarget assignments)

0

work_stopped

No

Cj1634c

15792939

aroC

chorismate synthase

362

Drug Target Function

Phase 2: March 2008

1SQ1

100%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02691
(show subtarget assignments)

1

purified

No

FTT0943c

56708040

folB

dihydroneopterin aldolase [Francisella t...

117

Drug Target

Phase 3: June 2008

1SQL

28.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01033
(show subtarget assignments)

1

soluble

No

STM3815

16767100

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00993
(show subtarget assignments)

0

work_stopped

No

STM2250

16765578

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02292
(show subtarget assignments)

1

expressed

No

Cj0078c

15791468

cdtB

cytolethal distending toxin [Campylobact...

265

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

1SR4

50.9%

Campylobacter jejuni

Cellular processes

Pathogenesis

IDP02306
(show subtarget assignments)

1

cloned

No

Cj0079c

15791469

cdtA

cytolethal distending toxin [Campylobact...

268

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

1SR4

24.3%

Campylobacter jejuni

Cellular processes

Pathogenesis

IDP05271
(show subtarget assignments)

1

cloned

No

lmo1194

16803234

cbiD

cobalt-precorrin-6A synthase [Listeria m...

373

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1SR8

23.1%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91684
(show subtarget assignments)

8

selected

No

NCAP_CVHSA

0

422

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SSK

32.9%

SARS coronavirus

IDP02290
(show subtarget assignments)

1

expressed

No

GBAA3674

47528959

ahpC/TSA family protein [Bacillus anthra...

191

Drug target motif; Involved in sporulation;

Phase 3: June 2008

1ST9

29.8%

Bacillus anthracis

Unknown function

General

IDP02734
(show subtarget assignments)

1

cloned

No

GBAA1779

47527069

thioredoxin family protein [Bacillus ant...

184

Drug target motif; Drug target functions

Phase 3: June 2008

1ST9

27.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02519
(show subtarget assignments)

1

cloned

No

GBAA1494

47526768

resA

thiol-disulfide oxidoreductase [Bacillus...

173

Conserved; Drug target functions

Phase 3: June 2008

1ST9

41.6%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02375
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4701

47530000

engB

GTPase EngB [Bacillus anthracis str. 'Am...

198

Conserved; Essential;

Phase 3: June 2008

1SUL

72.2%

Bacillus anthracis

Unknown function

General

IDP00257
(show subtarget assignments)

1

in_crystallization_trials

No

MODVgp1

20177456

Modoc virus Envelope protein

393

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1SVB

41%

Modoc virus

IDP02326
(show subtarget assignments)

1

purified

No

FTT0976

56708068

trxA2

thioredoxin [Francisella tularensis subs...

108

Drug Target

Phase 3: June 2008

1SYR

41.7%

Francisella tularensis

Energy metabolism

Electron transport

IDP02807
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4705

47530004

tig

trigger factor [Bacillus anthracis str. ...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T11

32.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization