Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90143 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_189	68449260		bifunctional IL-1-beta-inhibitor/prevent...	210	contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184	Community Requests	3O4O	29.5%	Monkeypox virus

IDP91968 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100007436	298255418		zinc-binding lipoprotein AdcA [Streptoco...	501	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2O1E	29.5%	Streptococcus pneumoniae

IDP02319 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1169	47526434	prsA	peptidylprolyl isomerase [Bacillus anthr...	285	Drug target motif; Drug target functions	Phase 3: June 2008	3RFW	29.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01352 (show subtarget assignments)	1	soluble	No	VCA0447	15601210		haemagglutinin associated protein	230	Conserved Gene / Pathway	Phase 2: March 2008	1G60	29.5%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP90729 (show subtarget assignments)	8	crystallized	No	Cj0572	15791932	ribA	bifunctional 3,4-dihydroxy-2-butanone 4-...	339	Predicted Essential	Community Requests	3MGZ	29.5%	Campylobacter jejuni

IDP01243 (show subtarget assignments)	1	cloned	No	BA_2345	30256982		penicillin-binding protein 1A	820	Drug Target Function	Phase 2: March 2008	2OLU	29.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05600 (show subtarget assignments)	1	soluble	No	BA_3645	30258170		putative oligopeptide ABC transporter, o...	562	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.5%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01997 (show subtarget assignments)	1	cloned	No	STM4310	16767560		putative inner membrane protein [Salmone...	301	Conserved; Drug target functions	Phase 3: June 2008	3QQZ	29.6%	Salmonella enterica	Unknown function	General

IDP91926 (show subtarget assignments)	8	selected	No	SpneCM_010100003840	298254733	scpB	segregation and condensation protein B [...	189	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2Z99	29.6%	Streptococcus pneumoniae

IDP05180 (show subtarget assignments)	1	soluble	No	BA_3644	30258169		putative oligopeptide ABC transporter, o...	568	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TCF	29.6%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP00802 (show subtarget assignments)	1	cloned	No	SACOL1704	57284716	mreC	rod shape-determining protein MreC	280	Conserved Gene / Pathway	Phase 2: March 2008	2J5U	29.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05127 (show subtarget assignments)	1	soluble	No	BA_4652	30259150		putative substrate-binding family protei...	314	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HXP	29.6%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP90684 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1218c	15792542	ribA	riboflavin synthase subunit alpha [Campy...	203	Predicted Essential	Community Requests	1KZL	29.6%	Campylobacter jejuni

IDP01415 (show subtarget assignments)	1	in_crystallization_trials	No	VC1363	15641375		siroheme synthase component enzyme	312	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	29.6%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP05404 (show subtarget assignments)	1	soluble	No	BA_5628	30260080		iron compound ABC transporter, iron comp...	314	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HXP	29.6%	Bacillus anthracis	Transport and binding proteins: Cations and iron carrying compounds

IDP04370 (show subtarget assignments)	1	cloned	No	GBAA4766	47530065		iron compound ABC transporter, iron comp...	324	virulence factor; putative drug target function;	Phase 4: April 2009	3EIW	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00137 (show subtarget assignments)	1	in_crystallization_trials	No	VC_0959	9655418	VC0959	Vibrio cholerae O1 biovar eltor str. N16...	291	Virulence	Phase 1: October 2007	3NQR	29.6%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00304 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0038	29653401		3-oxoacyl-(acyl-carrier-protein) synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	29.6%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00358 (show subtarget assignments)	1	cloned	No	lmo2229	16804268		hypothetical protein lmo2229	714	Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs	Phase 2: March 2008	3UDF	29.7%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04087 (show subtarget assignments)	1	cloned	No	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP05158 (show subtarget assignments)	1	cloned	No	BA_1197	30255150		oligopeptide ABC transporter, oligopepti...	532	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3O9P	29.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04078 (show subtarget assignments)	1	expressed	No	YPCD1.09c	5832432	YPCD1.09c	hypothetical protein YPCD1.09c [Yersinia...	91	virulence factor; conserved gene;	Phase 4: April 2009	3KXE	29.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01627 (show subtarget assignments)	1	cloned	No	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	Phase 3: June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02601 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2462	47527752		PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	2L2Q	29.7%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP02385 (show subtarget assignments)	1	cloned	No	Cj0755	15792094	cfrA	putative iron uptake protein [Campylobac...	696	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	2HDF	29.8%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04198 (show subtarget assignments)	1	soluble	No	CPF_2555	110799167		oligopeptide/dipeptide ABC transporter, ...	580	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XOC	29.8%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP02290 (show subtarget assignments)	1	expressed	No	GBAA3674	47528959		ahpC/TSA family protein [Bacillus anthra...	191	Drug target motif; Involved in sporulation;	Phase 3: June 2008	1ST9	29.8%	Bacillus anthracis	Unknown function	General

IDP00515 (show subtarget assignments)	1	cloned	No	YPO3922	16124053		hemophore HasA	205	Virulence Associated Factor	Phase 2: March 2008	1B2V	29.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP92069 (show subtarget assignments)	8	selected	No	TGME49_081920	237844207		vacuolar ATP synthase subunit D, putativ...	245	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3A5C	29.8%	Toxoplasma gondii

IDP04637 (show subtarget assignments)	1	cloned	No	FTT0371c	56707522	folC	FolC bifunctional protein [Francisella t...	393	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1W78	29.8%	Francisella tularensis

IDP90217 (show subtarget assignments)	8	soluble	No	MYXV_gp004	9633795	m003.1L	m003.1L, m3.1	151	similar to VACV-Cop:B22R, member of Poxvirus A4/B15 family. This is a family of ...	Community Requests	2VVY	29.8%	Myxoma virus	unknown	0

IDP05086 (show subtarget assignments)	1	soluble	No	BA_0014	30253529		deoxynucleoside kinase family protein [B...	222	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2A2Z	29.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP00686 (show subtarget assignments)	1	purified	No	SACOL2029	57284899	cscA	sucrose-6-phosphate hydrolase	494	Drug Target Function	Phase 2: March 2008	1UYP	29.8%	Staphylococcus aureus	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP91918 (show subtarget assignments)	8	selected	No	SpneCM_010100009348	298255780		surface protein PspA, partial [Streptoco...	429	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2V04	29.8%	Streptococcus pneumoniae

IDP05188 (show subtarget assignments)	1	purified	No	CD0235	126697806	fliS1	flagellar protein FliS [Clostridium diff...	131	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VH6	29.8%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05643 (show subtarget assignments)	1	soluble	No	CD3082	126700699		PTS system, IIB component [Clostridium d...	114	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1H9C	29.8%	Clostridium difficile	Signal transduction: PTS

IDP05229 (show subtarget assignments)	1	cloned	No	lmo1286	16803326	parE	DNA topoisomerase IV subunit B [Listeria...	655	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1EI1	29.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP91376 (show subtarget assignments)	8	purified	No	VV1_1694	27365055		hypothetical protein VV1_1694 [Vibrio vu...	151	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1IB8	29.8%	Vibrio vulnificus

IDP05150 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0195	30253702		putative oligopeptide ABC transporter, o...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.9%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP02170 (show subtarget assignments)	1	soluble	No	FTT1010	56708100		helix-turn-helix family protein [Francis...	67	Drug Target	Phase 3: June 2008	3T75	29.9%	Francisella tularensis	Unknown function	General

IDP02321 (show subtarget assignments)	1	cloned	No	FTT0077	56707256	sucB	dihydrolipoamide succinyltransferase com...	489	Conserved; Drug target functions	Phase 3: June 2008	1C4T	29.9%	Francisella tularensis	Energy metabolism	TCA cycle

IDP05379 (show subtarget assignments)	1	soluble	No	BA_5417	30259888	cccB	cytochrome c-551 [Bacillus anthracis str...	107	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B7V	29.9%	Bacillus anthracis	Energy metabolism: Electron transport

IDP91735 (show subtarget assignments)	8	selected	No	Q4W8J9_STAAU	0			663	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2A1D	29.9%	Staphylococcus aureus

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00510 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3572	16123716		hypothetical protein YPO3572	207	Virulence Associated Factor	Phase 2: March 2008	2QGU	30%	Yersinia pestis	Cell envelope	Other

IDP05664 (show subtarget assignments)	1	purified	No	lmo0341	16802386	-	hypothetical protein lmo0341 [Listeria m...	110	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IP6	30%	Listeria monocytogenes	Transport and binding proteins: Other

IDP02475 (show subtarget assignments)	1	cloned	No	GBAA3660	47528945		serine protease [Bacillus anthracis str....	413	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZLE	30%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02476 (show subtarget assignments)	1	cloned	No	YPO1776	16122030	dbpA	ATP-dependent RNA helicase DbpA [Yersini...	460	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2I4I	30%	Yersinia pestis	Transcription	Transcription factors

IDP05136 (show subtarget assignments)	1	in_crystallization_trials	No	CD0886	126698463		putative alpha-amylase [Clostridium diff...	621	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1IZJ	30%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01163 (show subtarget assignments)	1	purified	No	BA_5526	30259986		ABC transporter, ATP-binding protein	280	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP90950 (show subtarget assignments)	8	soluble	No	ZZZ_0018	51094326	MAPK-1	mitogen-activated protein kinase 1	532	Drug Target Homolog	Community Requests	3OHT	30.1%	Toxoplasma gondii

IDP02503 (show subtarget assignments)	1	cloned	No	YPO2502	16122723	gutB	putative zinc-binding dehydrogenase [Yer...	408	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	2D8A	30.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Chlorophyll and bacteriochlorphyll

IDP01450 (show subtarget assignments)	1	in_crystallization_trials	No	VC2269	15642267		3,4-dihydroxy-2-butanone 4-phosphate syn...	369	Drug Target Function	Phase 2: March 2008	1G57	30.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02820 (show subtarget assignments)	1	purified	No	lmo2196	16804235		hypothetical protein lmo2196 [Listeria m...	558	Known virulence-Intracellular Survival; PMID:11083832	Phase 3: June 2008	1B05	30.1%	Listeria monocytogenes	Cellular processes	DNA transformation

IDP02018 (show subtarget assignments)	1	expressed	No	STM2530	16765850		putative anaerobic dimethylsulfoxide red...	801	Conserved; Drug target functions	Phase 3: June 2008	1DMR	30.1%	Salmonella enterica	Energy metabolism	Anaerobic

IDP90702 (show subtarget assignments)	8	expressed	No	Cj0134	15791522	thrB	homoserine kinase [Campylobacter jejuni ...	292	Predicted Essential	Community Requests	3HUL	30.2%	Campylobacter jejuni

IDP92033 (show subtarget assignments)	8	selected	No	TGME49_019850	237842879		prolyl-tRNA synthetase, putative [Toxopl...	711	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1H4Q	30.2%	Toxoplasma gondii

IDP04547 (show subtarget assignments)	1	cloned	No	CPF_0581	110800184		amino acid ABC transporter, amino acid-b...	278	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PVU	30.2%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP05149 (show subtarget assignments)	1	purified	No	BA_0194	30253701		putative oligopeptide ABC transporter, o...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	30.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05290 (show subtarget assignments)	1	cloned	No	CD0488	126698065	sugE	quaternary ammonium compound-resistance ...	106	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2I68	30.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP90698 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1531	15792839	dapF	diaminopimelate epimerase [Campylobacter...	249	Predicted Essential	Community Requests	3EJX	30.2%	Campylobacter jejuni

IDP90518 (show subtarget assignments)	8	purified	No	Cj1404	15792722		hypothetical protein Cj1404 [Campylobact...	181	Predicted Essential	Community Requests	1KAM	30.2%	Campylobacter jejuni

IDP01741 (show subtarget assignments)	1	cloned	No	Cj1332	15792655	ptmA	flagellin modification protein A [Campyl...	256	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008	3QIV	30.2%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00687 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2038	57284907		O-sialoglycoprotein endopeptidase	341	Drug Target Function	Phase 2: March 2008	2IVN	30.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05499 (show subtarget assignments)	1	soluble	No	BA_4322	30258823		5'-nucleotidase family protein [Bacillus...	529	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z1A	30.2%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01310 (show subtarget assignments)	1	purified	No	VC2251	15642249		outer membrane protein OmpH	169	Conserved Gene / Pathway	Phase 2: March 2008	1SG2	30.2%	Vibrio cholerae	Cell envelope	Other

IDP01149 (show subtarget assignments)	1	purified	No	BA_1195	30254908		oligopeptide ABC transporter, ATP-bindin...	311	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	30.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP05139 (show subtarget assignments)	1	soluble	No	BAS0353	49183381	-	amino acid ABC transporter, solute bindi...	264	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQL	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP00930 (show subtarget assignments)	1	expressed	No	STM0612	16763989		putative hydrogenase protein	185	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	30.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP05181 (show subtarget assignments)	1	soluble	No	BA_4729	30259221		bacterial extracellular solute-binding p...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1UQW	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP00187 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0773	16121086	-	putative thioesterase	254	Virulence	Phase 1: October 2007	3FLA	30.3%	Yersinia pestis	Regulatory functions	Other

IDP05040 (show subtarget assignments)	1	expressed	No	BA_2262	30256905		heat shock protein, Hsp20 family [Bacill...	145	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1GME	30.3%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions

IDP01447 (show subtarget assignments)	1	in_crystallization_trials	No	VC2181	15642180	lolB	outer membrane lipoprotein LolB	211	Conserved Gene / Pathway	Phase 2: March 2008	1IWM	30.3%	Vibrio cholerae	Cell envelope	Other

IDP90667 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1535c	15792843	pgi	glucose-6-phosphate isomerase [Campyloba...	406	Predicted Essential	Community Requests	1ZZG	30.3%	Campylobacter jejuni

IDP00148 (show subtarget assignments)	1	soluble	No	VCA0227	15600996	vctP	vibriobactin and enterobactin ABC transp...	333	Virulence	Phase 1: October 2007	3GFV	30.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02522 (show subtarget assignments)	1	expressed	No	CBU_1966	29542521	hemA	glutamyl-tRNA reductase [Coxiella burnet...	413	Conserved; Drug target functions	Phase 3: June 2008	1GPJ	30.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01124 (show subtarget assignments)	1	purified	No	BA_4938	33301353		UDP-N-acetylmuramate--L-alanine ligase (...	436	Conserved Gene / Pathway	Phase 2: March 2008	1J6U	30.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91484 (show subtarget assignments)	8	in_crystallization_trials	No	VP1701	28898475		putative exoenzyme S synthesis protein C...	148	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3KXY	30.4%	Vibrio parahaemolyticus

IDP92013 (show subtarget assignments)	8	selected	No	TGME49_034280	237839141		adenosine monophosphate deaminase, putat...	914	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2A3L	30.4%	Toxoplasma gondii

IDP02752 (show subtarget assignments)	1	crystallized	No	FTT0650c	56707772	grxB	glutaredoxin 2 [Francisella tularensis s...	214	Drug Target	Phase 3: June 2008	3IR4	30.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Glutathione and analogs

IDP00661 (show subtarget assignments)	1	purified	No	SACOL0827	57284289		acetyltransferase, putative	161	Drug Target Function	Phase 2: March 2008	1OCX	30.4%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP00566 (show subtarget assignments)	1	purified	No	YPO0279	16120618	hmuV	hemin transport system ATP-binding prote...	266	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	30.5%	Yersinia pestis	Transport and binding proteins	Other

IDP01780 (show subtarget assignments)	1	in_crystallization_trials	No	STM0784	16764148	ybhA	phosphotransferase [Salmonella typhimuri...	272	Conserved; Drug target functions	Phase 3: June 2008	2PQ0	30.5%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP92107 (show subtarget assignments)	8	selected	No	TGME49_091640	237838437		aspartate carbamoyltransferase [Toxoplas...	423	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1AT1	30.5%	Toxoplasma gondii

IDP91748 (show subtarget assignments)	8	selected	No	Q933J5_PSEAE	0			453	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1R4T	30.5%	Pseudomonas aeruginosa

IDP02405 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1803c	56708789	trpR	trp operon repressor [Francisella tulare...	95	Drug Target	Phase 3: June 2008	1CO0	30.5%	Francisella tularensis	Amino acid biosynthesisRegulatory functions	Aromatic amino acid familyDNA interactions

IDP00593 (show subtarget assignments)	1	expressed	No	YPO1232	16121518	msgA	putative stress response protein	80	Conserved Gene / Pathway	Phase 2: March 2008	1GHH	30.5%	Yersinia pestis	Cellular processes	Pathogenesis

IDP90190 (show subtarget assignments)	8	cloned	No	AAM13631.1	20153170	CrmC	CrmC or CPXV191 protein	186	soluble vTNF receptor CrmC	Community Requests	3ALQ	30.6%	Cowpox virus	host defense modulator	0

IDP92046 (show subtarget assignments)	8	selected	No	TGME49_007640	211967232		isoleucine-tRNA synthetase, putative [To...	1103	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1ILE	30.6%	Toxoplasma gondii

IDP00707 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0704	57285674		iron compound ABC transporter, ATP-bindi...	265	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	30.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP91269 (show subtarget assignments)	8	soluble	No	NT05BA2958	49179731		acetyltransferase, GNAT family [Bacillus...	180	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1NSL	30.6%	Bacillus anthracis	Protein synthesis: Ribosomal proteins: synthesis and modification

IDP90673 (show subtarget assignments)	8	expressed	No	VC1833	15641835		quinolinate synthetase [Vibrio cholerae ...	353	Predicted Essential	Community Requests	1WZU	30.6%	Vibrio cholerae

IDP00145 (show subtarget assignments)	1	expressed	No	VC0777	15640796	viuD	vibriobactin and enterobactin ABC transp...	350	Virulence	Phase 1: October 2007	2NQ2	30.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05318 (show subtarget assignments)	1	soluble	No	lmo0697	16802739	-	flagellar hook protein FlgE [Listeria mo...	411	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A69	30.6%	Listeria monocytogenes	Cellular processes: Chemotaxis and motility

IDP02513 (show subtarget assignments)	1	soluble	No	GBAA0258	47525517		hypothetical protein GBAA0258 [Bacillus ...	157	Conserved;	Phase 3: June 2008	1FL9	30.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP00025 (show subtarget assignments)	1	purified	No	BA_0285	30253779		bacitracin ABC transporter, ATP-binding ...	309	Virulence	Phase 1: October 2007	1OXS	30.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP04109 (show subtarget assignments)	1	crystallized	No	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP90143
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_189

68449260

bifunctional IL-1-beta-inhibitor/prevent...

210

contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184

Community Requests

3O4O

29.5%

Monkeypox virus

IDP91968
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100007436

298255418

zinc-binding lipoprotein AdcA [Streptoco...

501

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2O1E

29.5%

Streptococcus pneumoniae

IDP02319
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1169

47526434

prsA

peptidylprolyl isomerase [Bacillus anthr...

285

Drug target motif; Drug target functions

Phase 3: June 2008

3RFW

29.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01352
(show subtarget assignments)

1

soluble

No

VCA0447

15601210

haemagglutinin associated protein

230

Conserved Gene / Pathway

Phase 2: March 2008

1G60

29.5%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP90729
(show subtarget assignments)

8

crystallized

No

Cj0572

15791932

ribA

bifunctional 3,4-dihydroxy-2-butanone 4-...

339

Predicted Essential

Community Requests

3MGZ

29.5%

Campylobacter jejuni

IDP01243
(show subtarget assignments)

1

cloned

No

BA_2345

30256982

penicillin-binding protein 1A

820

Drug Target Function

Phase 2: March 2008

2OLU

29.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05600
(show subtarget assignments)

1

soluble

No

BA_3645

30258170

putative oligopeptide ABC transporter, o...

562

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.5%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01997
(show subtarget assignments)

1

cloned

No

STM4310

16767560

putative inner membrane protein [Salmone...

301

Conserved; Drug target functions

Phase 3: June 2008

3QQZ

29.6%

Salmonella enterica

Unknown function

General

IDP91926
(show subtarget assignments)

8

selected

No

SpneCM_010100003840

298254733

scpB

segregation and condensation protein B [...

189

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2Z99

29.6%

Streptococcus pneumoniae

IDP05180
(show subtarget assignments)

1

soluble

No

BA_3644

30258169

putative oligopeptide ABC transporter, o...

568

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TCF

29.6%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP00802
(show subtarget assignments)

1

cloned

No

SACOL1704

57284716

mreC

rod shape-determining protein MreC

280

Conserved Gene / Pathway

Phase 2: March 2008

2J5U

29.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05127
(show subtarget assignments)

1

soluble

No

BA_4652

30259150

putative substrate-binding family protei...

314

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HXP

29.6%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP90684
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1218c

15792542

ribA

riboflavin synthase subunit alpha [Campy...

203

Predicted Essential

Community Requests

1KZL

29.6%

Campylobacter jejuni

IDP01415
(show subtarget assignments)

1

in_crystallization_trials

No

VC1363

15641375

siroheme synthase component enzyme

312

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

29.6%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP05404
(show subtarget assignments)

1

soluble

No

BA_5628

30260080

iron compound ABC transporter, iron comp...

314

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HXP

29.6%

Bacillus anthracis

Transport and binding proteins: Cations and iron carrying compounds

IDP04370
(show subtarget assignments)

1

cloned

No

GBAA4766

47530065

iron compound ABC transporter, iron comp...

324

virulence factor; putative drug target function;

Phase 4: April 2009

3EIW

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00137
(show subtarget assignments)

1

in_crystallization_trials

No

VC_0959

9655418

VC0959

Vibrio cholerae O1 biovar eltor str. N16...

291

Virulence

Phase 1: October 2007

3NQR

29.6%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00304
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0038

29653401

3-oxoacyl-(acyl-carrier-protein) synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

29.6%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00358
(show subtarget assignments)

1

cloned

No

lmo2229

16804268

hypothetical protein lmo2229

714

Possible Vaccine Candidate; Presence of Protease Motifs; Drug Target Homologs

Phase 2: March 2008

3UDF

29.7%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04087
(show subtarget assignments)

1

cloned

No

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP05158
(show subtarget assignments)

1

cloned

No

BA_1197

30255150

oligopeptide ABC transporter, oligopepti...

532

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3O9P

29.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04078
(show subtarget assignments)

1

expressed

No

YPCD1.09c

5832432

YPCD1.09c

hypothetical protein YPCD1.09c [Yersinia...

91

virulence factor; conserved gene;

Phase 4: April 2009

3KXE

29.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01627
(show subtarget assignments)

1

cloned

No

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

Phase 3: June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02601
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2462

47527752

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

2L2Q

29.7%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP02385
(show subtarget assignments)

1

cloned

No

Cj0755

15792094

cfrA

putative iron uptake protein [Campylobac...

696

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

2HDF

29.8%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04198
(show subtarget assignments)

1

soluble

No

CPF_2555

110799167

oligopeptide/dipeptide ABC transporter, ...

580

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XOC

29.8%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP02290
(show subtarget assignments)

1

expressed

No

GBAA3674

47528959

ahpC/TSA family protein [Bacillus anthra...

191

Drug target motif; Involved in sporulation;

Phase 3: June 2008

1ST9

29.8%

Bacillus anthracis

Unknown function

General

IDP00515
(show subtarget assignments)

1

cloned

No

YPO3922

16124053

hemophore HasA

205

Virulence Associated Factor

Phase 2: March 2008

1B2V

29.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP92069
(show subtarget assignments)

8

selected

No

TGME49_081920

237844207

vacuolar ATP synthase subunit D, putativ...

245

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3A5C

29.8%

Toxoplasma gondii

IDP04637
(show subtarget assignments)

1

cloned

No

FTT0371c

56707522

folC

FolC bifunctional protein [Francisella t...

393

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1W78

29.8%

Francisella tularensis

IDP90217
(show subtarget assignments)

8

soluble

No

MYXV_gp004

9633795

m003.1L

m003.1L, m3.1

151

Community Requests

2VVY

29.8%

Myxoma virus

unknown

0

IDP05086
(show subtarget assignments)

1

soluble

No

BA_0014

30253529

deoxynucleoside kinase family protein [B...

222

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2A2Z

29.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP00686
(show subtarget assignments)

1

purified

No

SACOL2029

57284899

cscA

sucrose-6-phosphate hydrolase

494

Drug Target Function

Phase 2: March 2008

1UYP

29.8%

Staphylococcus aureus

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP91918
(show subtarget assignments)

8

selected

No

SpneCM_010100009348

298255780

surface protein PspA, partial [Streptoco...

429

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2V04

29.8%

Streptococcus pneumoniae

IDP05188
(show subtarget assignments)

1

purified

No

CD0235

126697806

fliS1

flagellar protein FliS [Clostridium diff...

131

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VH6

29.8%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05643
(show subtarget assignments)

1

soluble

No

CD3082

126700699

PTS system, IIB component [Clostridium d...

114

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1H9C

29.8%

Clostridium difficile

Signal transduction: PTS

IDP05229
(show subtarget assignments)

1

cloned

No

lmo1286

16803326

parE

DNA topoisomerase IV subunit B [Listeria...

655

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1EI1

29.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP91376
(show subtarget assignments)

8

purified

No

VV1_1694

27365055

hypothetical protein VV1_1694 [Vibrio vu...

151

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1IB8

29.8%

Vibrio vulnificus

IDP05150
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0195

30253702

putative oligopeptide ABC transporter, o...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.9%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP02170
(show subtarget assignments)

1

soluble

No

FTT1010

56708100

helix-turn-helix family protein [Francis...

67

Drug Target

Phase 3: June 2008

3T75

29.9%

Francisella tularensis

Unknown function

General

IDP02321
(show subtarget assignments)

1

cloned

No

FTT0077

56707256

sucB

dihydrolipoamide succinyltransferase com...

489

Conserved; Drug target functions

Phase 3: June 2008

1C4T

29.9%

Francisella tularensis

Energy metabolism

TCA cycle

IDP05379
(show subtarget assignments)

1

soluble

No

BA_5417

30259888

cccB

cytochrome c-551 [Bacillus anthracis str...

107

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B7V

29.9%

Bacillus anthracis

Energy metabolism: Electron transport

IDP91735
(show subtarget assignments)

8

selected

No

Q4W8J9_STAAU

0

663

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2A1D

29.9%

Staphylococcus aureus

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00510
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3572

16123716

hypothetical protein YPO3572

207

Virulence Associated Factor

Phase 2: March 2008

2QGU

30%

Yersinia pestis

Cell envelope

Other

IDP05664
(show subtarget assignments)

1

purified

No

lmo0341

16802386

-

hypothetical protein lmo0341 [Listeria m...

110

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IP6

30%

Listeria monocytogenes

Transport and binding proteins: Other

IDP02475
(show subtarget assignments)

1

cloned

No

GBAA3660

47528945

serine protease [Bacillus anthracis str....

413

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZLE

30%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02476
(show subtarget assignments)

1

cloned

No

YPO1776

16122030

dbpA

ATP-dependent RNA helicase DbpA [Yersini...

460

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2I4I

30%

Yersinia pestis

Transcription

Transcription factors

IDP05136
(show subtarget assignments)

1

in_crystallization_trials

No

CD0886

126698463

putative alpha-amylase [Clostridium diff...

621

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1IZJ

30%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01163
(show subtarget assignments)

1

purified

No

BA_5526

30259986

ABC transporter, ATP-binding protein

280

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP90950
(show subtarget assignments)

8

soluble

No

ZZZ_0018

51094326

MAPK-1

mitogen-activated protein kinase 1

532

Drug Target Homolog

Community Requests

3OHT

30.1%

Toxoplasma gondii

IDP02503
(show subtarget assignments)

1

cloned

No

YPO2502

16122723

gutB

putative zinc-binding dehydrogenase [Yer...

408

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

2D8A

30.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Chlorophyll and bacteriochlorphyll

IDP01450
(show subtarget assignments)

1

in_crystallization_trials

No

VC2269

15642267

3,4-dihydroxy-2-butanone 4-phosphate syn...

369

Drug Target Function

Phase 2: March 2008

1G57

30.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02820
(show subtarget assignments)

1

purified

No

lmo2196

16804235

hypothetical protein lmo2196 [Listeria m...

558

Known virulence-Intracellular Survival; PMID:11083832

Phase 3: June 2008

1B05

30.1%

Listeria monocytogenes

Cellular processes

DNA transformation

IDP02018
(show subtarget assignments)

1

expressed

No

STM2530

16765850

putative anaerobic dimethylsulfoxide red...

801

Conserved; Drug target functions

Phase 3: June 2008

1DMR

30.1%

Salmonella enterica

Energy metabolism

Anaerobic

IDP90702
(show subtarget assignments)

8

expressed

No

Cj0134

15791522

thrB

homoserine kinase [Campylobacter jejuni ...

292

Predicted Essential

Community Requests

3HUL

30.2%

Campylobacter jejuni

IDP92033
(show subtarget assignments)

8

selected

No

TGME49_019850

237842879

prolyl-tRNA synthetase, putative [Toxopl...

711

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1H4Q

30.2%

Toxoplasma gondii

IDP04547
(show subtarget assignments)

1

cloned

No

CPF_0581

110800184

amino acid ABC transporter, amino acid-b...

278

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PVU

30.2%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP05149
(show subtarget assignments)

1

purified

No

BA_0194

30253701

putative oligopeptide ABC transporter, o...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

30.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05290
(show subtarget assignments)

1

cloned

No

CD0488

126698065

sugE

quaternary ammonium compound-resistance ...

106

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2I68

30.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP90698
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1531

15792839

dapF

diaminopimelate epimerase [Campylobacter...

249

Predicted Essential

Community Requests

3EJX

30.2%

Campylobacter jejuni

IDP90518
(show subtarget assignments)

8

purified

No

Cj1404

15792722

hypothetical protein Cj1404 [Campylobact...

181

Predicted Essential

Community Requests

1KAM

30.2%

Campylobacter jejuni

IDP01741
(show subtarget assignments)

1

cloned

No

Cj1332

15792655

ptmA

flagellin modification protein A [Campyl...

256

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

3QIV

30.2%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00687
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2038

57284907

O-sialoglycoprotein endopeptidase

341

Drug Target Function

Phase 2: March 2008

2IVN

30.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05499
(show subtarget assignments)

1

soluble

No

BA_4322

30258823

5'-nucleotidase family protein [Bacillus...

529

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z1A

30.2%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01310
(show subtarget assignments)

1

purified

No

VC2251

15642249

outer membrane protein OmpH

169

Conserved Gene / Pathway

Phase 2: March 2008

1SG2

30.2%

Vibrio cholerae

Cell envelope

Other

IDP01149
(show subtarget assignments)

1

purified

No

BA_1195

30254908

oligopeptide ABC transporter, ATP-bindin...

311

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

30.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP05139
(show subtarget assignments)

1

soluble

No

BAS0353

49183381

-

amino acid ABC transporter, solute bindi...

264

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQL

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP00930
(show subtarget assignments)

1

expressed

No

STM0612

16763989

putative hydrogenase protein

185

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

30.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP05181
(show subtarget assignments)

1

soluble

No

BA_4729

30259221

bacterial extracellular solute-binding p...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1UQW

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP00187
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0773

16121086

-

putative thioesterase

254

Virulence

Phase 1: October 2007

3FLA

30.3%

Yersinia pestis

Regulatory functions

Other

IDP05040
(show subtarget assignments)

1

expressed

No

BA_2262

30256905

heat shock protein, Hsp20 family [Bacill...

145

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1GME

30.3%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

IDP01447
(show subtarget assignments)

1

in_crystallization_trials

No

VC2181

15642180

lolB

outer membrane lipoprotein LolB

211

Conserved Gene / Pathway

Phase 2: March 2008

1IWM

30.3%

Vibrio cholerae

Cell envelope

Other

IDP90667
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1535c

15792843

pgi

glucose-6-phosphate isomerase [Campyloba...

406

Predicted Essential

Community Requests

1ZZG

30.3%

Campylobacter jejuni

IDP00148
(show subtarget assignments)

1

soluble

No

VCA0227

15600996

vctP

vibriobactin and enterobactin ABC transp...

333

Virulence

Phase 1: October 2007

3GFV

30.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02522
(show subtarget assignments)

1

expressed

No

CBU_1966

29542521

hemA

glutamyl-tRNA reductase [Coxiella burnet...

413

Conserved; Drug target functions

Phase 3: June 2008

1GPJ

30.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01124
(show subtarget assignments)

1

purified

No

BA_4938

33301353

UDP-N-acetylmuramate--L-alanine ligase (...

436

Conserved Gene / Pathway

Phase 2: March 2008

1J6U

30.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91484
(show subtarget assignments)

8

in_crystallization_trials

No

VP1701

28898475

putative exoenzyme S synthesis protein C...

148

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3KXY

30.4%

Vibrio parahaemolyticus

IDP92013
(show subtarget assignments)

8

selected

No

TGME49_034280

237839141

adenosine monophosphate deaminase, putat...

914

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2A3L

30.4%

Toxoplasma gondii

IDP02752
(show subtarget assignments)

1

crystallized

No

FTT0650c

56707772

grxB

glutaredoxin 2 [Francisella tularensis s...

214

Drug Target

Phase 3: June 2008

3IR4

30.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Glutathione and analogs

IDP00661
(show subtarget assignments)

1

purified

No

SACOL0827

57284289

acetyltransferase, putative

161

Drug Target Function

Phase 2: March 2008

1OCX

30.4%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP00566
(show subtarget assignments)

1

purified

No

YPO0279

16120618

hmuV

hemin transport system ATP-binding prote...

266

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

30.5%

Yersinia pestis

Transport and binding proteins

Other

IDP01780
(show subtarget assignments)

1

in_crystallization_trials

No

STM0784

16764148

ybhA

phosphotransferase [Salmonella typhimuri...

272

Conserved; Drug target functions

Phase 3: June 2008

2PQ0

30.5%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP92107
(show subtarget assignments)

8

selected

No

TGME49_091640

237838437

aspartate carbamoyltransferase [Toxoplas...

423

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1AT1

30.5%

Toxoplasma gondii

IDP91748
(show subtarget assignments)

8

selected

No

Q933J5_PSEAE

0

453

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1R4T

30.5%

Pseudomonas aeruginosa

IDP02405
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1803c

56708789

trpR

trp operon repressor [Francisella tulare...

95

Drug Target

Phase 3: June 2008

1CO0

30.5%

Francisella tularensis

Amino acid biosynthesisRegulatory functions

Aromatic amino acid familyDNA interactions

IDP00593
(show subtarget assignments)

1

expressed

No

YPO1232

16121518

msgA

putative stress response protein

80

Conserved Gene / Pathway

Phase 2: March 2008

1GHH

30.5%

Yersinia pestis

Cellular processes

Pathogenesis

IDP90190
(show subtarget assignments)

8

cloned

No

AAM13631.1

20153170

CrmC

CrmC or CPXV191 protein

186

soluble vTNF receptor CrmC

Community Requests

3ALQ

30.6%

Cowpox virus

host defense modulator

0

IDP92046
(show subtarget assignments)

8

selected

No

TGME49_007640

211967232

isoleucine-tRNA synthetase, putative [To...

1103

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1ILE

30.6%

Toxoplasma gondii

IDP00707
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0704

57285674

iron compound ABC transporter, ATP-bindi...

265

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

30.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP91269
(show subtarget assignments)

8

soluble

No

NT05BA2958

49179731

acetyltransferase, GNAT family [Bacillus...

180

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1NSL

30.6%

Bacillus anthracis

Protein synthesis: Ribosomal proteins: synthesis and modification

IDP90673
(show subtarget assignments)

8

expressed

No

VC1833

15641835

quinolinate synthetase [Vibrio cholerae ...

353

Predicted Essential

Community Requests

1WZU

30.6%

Vibrio cholerae

IDP00145
(show subtarget assignments)

1

expressed

No

VC0777

15640796

viuD

vibriobactin and enterobactin ABC transp...

350

Virulence

Phase 1: October 2007

2NQ2

30.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05318
(show subtarget assignments)

1

soluble

No

lmo0697

16802739

-

flagellar hook protein FlgE [Listeria mo...

411

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A69

30.6%

Listeria monocytogenes

Cellular processes: Chemotaxis and motility

IDP02513
(show subtarget assignments)

1

soluble

No

GBAA0258

47525517

hypothetical protein GBAA0258 [Bacillus ...

157

Conserved;

Phase 3: June 2008

1FL9

30.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP00025
(show subtarget assignments)

1

purified

No

BA_0285

30253779

bacitracin ABC transporter, ATP-binding ...

309

Virulence

Phase 1: October 2007

1OXS

30.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP04109
(show subtarget assignments)

1

crystallized

No

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds