Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02424 (show subtarget assignments)	1	cloned	No	FTT1147c	56708218	dfp	4'-phosphopantothenoylcysteine decarboxy...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	19.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02423 (show subtarget assignments)	1	cloned	No	FTT1138	56708213	hemH	ferrochelatase [Francisella tularensis s...	333	Drug Target	Phase 3: June 2008	1HRK	27.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00165 (show subtarget assignments)	1	cloned	No	VC0844	15640861	acfA	accessory colonization factor AcfA	215	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01453 (show subtarget assignments)	1	cloned	No	VC2401	15642398	murG	N-acetylglucosaminyl transferase	354	Conserved Gene / Pathway	Phase 2: March 2008	1F0K	63.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05064 (show subtarget assignments)	1	cloned	No	CD2370	126699985	nadC	nicotinate-nucleotide pyrophosphorylase ...	270	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1X1O	46.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05066 (show subtarget assignments)	1	cloned	No	CD2654	126700268	mraY	phospho-N-acetylmuramoyl-pentapeptide-tr...	321	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04031 (show subtarget assignments)	1	cloned	No	CBU_A0011	29648123		hypothetical protein CBUA0011 [Coxiella ...	56	drug target;	Phase 4: April 2009			Coxiella burnetii	Hypothetical proteins	Domain

IDP01457 (show subtarget assignments)	1	cloned	No	VC2407	15642404		penicillin-binding protein 3	580	Drug Target Function	Phase 2: March 2008	3OC2	41.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00738 (show subtarget assignments)	1	cloned	No	SACOL0994	57284368	oppF	oligopeptide ABC transporter, ATP-bindin...	313	Drug Target Function	Phase 2: March 2008	2YZ2	27.2%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP04065 (show subtarget assignments)	1	cloned	No	CPF_2985	110800289	yyaC	putative sporulation protein YyaC [Clost...	196	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01460 (show subtarget assignments)	1	cloned	No	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP00406 (show subtarget assignments)	1	cloned	No	YPO3410	16123559		hypothetical protein YPO3410	115	Virulence Associated Factor	Phase 2: March 2008	3UTK	26.1%	Yersinia pestis	Cell envelope	Other

IDP00740 (show subtarget assignments)	1	cloned	No	SACOL1105	57285891	pdhD	dihydrolipoamide dehydrogenase	468	Drug Target Function	Phase 2: March 2008	1EBD	70.9%	Staphylococcus aureus	Energy metabolism	Pyruvate dehydrogenase

IDP01651 (show subtarget assignments)	1	cloned	No	YPO2946	16123129	clpB5	Clp ATPase [Yersinia pestis CO92]	891	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	1QVR	35.5%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04732 (show subtarget assignments)	1	cloned	No	BAS5341	49188325		50S ribosomal protein L34 [Bacillus anth...	44	Proposed to be essential proteins	Phase 4: April 2009	1NKW	65.9%	Bacillus anthracis

IDP02438 (show subtarget assignments)	1	cloned	No	CBU_0029	29540654		acyltransferase family protein [Coxiella...	242	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP01863 (show subtarget assignments)	1	cloned	No	GBAA5548	47778410	atpG	F0F1 ATP synthase subunit gamma [Bacillu...	286	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2QE7	58.7%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP04074 (show subtarget assignments)	1	cloned	No	BAS4469	49187464		50S ribosomal protein L20 [Bacillus anth...	118	Proposed to be essential proteins	Phase 4: April 2009	1VS6	55.1%	Bacillus anthracis

IDP00408 (show subtarget assignments)	1	cloned	No	YPO2735	16122939	ccmB	heme exporter protein B	219	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP02440 (show subtarget assignments)	1	cloned	No	lmo0331	16802376		hypothetical protein lmo0331 [Listeria m...	633	Predicted virulence-Invasion; Predicted involvement or location on the cell wall...	Phase 3: June 2008	3BZ5	28.4%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP02444 (show subtarget assignments)	1	cloned	No	YPO2224	16122453		hypothetical protein YPO2224 [Yersinia p...	103	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP04080 (show subtarget assignments)	1	cloned	No	BAS0123	49183157		30S ribosomal protein S14 [Bacillus anth...	61	Proposed to be essential proteins	Phase 4: April 2009	1FJG	73.8%	Bacillus anthracis

IDP01472 (show subtarget assignments)	1	cloned	No	VC2631	15642626		fimbrial assembly protein PilP, putative...	172	Conserved Gene / Pathway	Phase 2: March 2008	2LC4	16.3%	Vibrio cholerae	Cell envelope	Surface structures

IDP02052 (show subtarget assignments)	1	cloned	No	YPO2924	16123111		hypothetical protein YPO2924 [Yersinia p...	215	Conserved; Drug target functions	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP05082 (show subtarget assignments)	1	cloned	No	lmo2179	16804218	-	peptidoglycan binding protein [Listeria ...	1152	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KT7	2.3%	Listeria monocytogenes	Regulatory functions: Other

IDP01763 (show subtarget assignments)	1	cloned	No	YPO3627	16123769	ssuB	aliphatic sulfonates transport ATP-bindi...	271	Conserved; CD; Drug target functions	Phase 3: June 2008	2IT1	35.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00410 (show subtarget assignments)	1	cloned	No	YPO0548	16120876	ftsL	cell division protein FtsL	105	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Cell division

IDP04087 (show subtarget assignments)	1	cloned	No	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP02061 (show subtarget assignments)	1	cloned	No	CBU_0147	29540767	secA	preprotein translocase, SecA subunit [Co...	913	Conserved; Drug target functions	Phase 3: June 2008	2FSF	59.9%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02461 (show subtarget assignments)	1	cloned	No	Cj0176c	15791563		putative lipoprotein [Campylobacter jeju...	43	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Cations and iron carrying compounds

IDP01480 (show subtarget assignments)	1	cloned	No	VCA0116	15600887		clpB protein	869	Drug Target Function	Phase 2: March 2008	1QVR	36.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00168 (show subtarget assignments)	1	cloned	No	VC2209	15642774	vibF	nonribosomal peptide synthetase VibF, au...	2413	Virulence	Phase 1: October 2007	2VSQ	10.2%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP01764 (show subtarget assignments)	1	cloned	No	Cj1434c	15792752		putative sugar transferase [Campylobacte...	445	Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...	Phase 3: June 2008	3L7I	16.2%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02055 (show subtarget assignments)	1	cloned	No	Cj1327	15792650	neuB2	N-acetylneuraminic acid synthetase [Camp...	334	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...	Phase 3: June 2008	1VLI	36.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04092 (show subtarget assignments)	1	cloned	No	CPF_1925	110801017	spoVS	stage V sporulation protein S [Clostridi...	86	conserved gene; putative drug target function;	Phase 4: April 2009	2EH1	57%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01767 (show subtarget assignments)	1	cloned	No	Cj1436c	15792754		putative aminotransferase [Campylobacter...	390	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3FTB	25.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01766 (show subtarget assignments)	1	cloned	No	GBAA_pXO2_0063	47566732	ggt	gamma-glutamyltranspeptidase, (pxo2-55) ...	528	Drug target motif; Drug target homolog;	Phase 3: June 2008	3G9K	61.2%	Bacillus anthracis	N/A	N/A

IDP04091 (show subtarget assignments)	1	cloned	No	CPF_1278	110799680		putative lipoprotein [Clostridium perfri...	155	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP00753 (show subtarget assignments)	1	cloned	No	SACOL0052	57286607		glycosyl transferase, group 1 family pro...	503	Conserved Gene / Pathway	Phase 2: March 2008	2F9F	9.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP02464 (show subtarget assignments)	1	cloned	No	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP05106 (show subtarget assignments)	1	cloned	No	CD1469	126699073		cell surface protein (putative penicilli...	990	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2QMI	10%	Clostridium difficile	Cell envelope: Other

IDP05008 (show subtarget assignments)	1	cloned	No	CD1777	126699386		putative arsenate reductase [Clostridium...	120	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3FZ4	41.7%	Clostridium difficile	Cellular processes: Detoxification

IDP02471 (show subtarget assignments)	1	cloned	No	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP01775 (show subtarget assignments)	1	cloned	No	Cj1331	15792654	ptmB	acylneuraminate cytidylyltransferase (fl...	235	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...	Phase 3: June 2008	1EYR	28.9%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01495 (show subtarget assignments)	1	cloned	No	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02483 (show subtarget assignments)	1	cloned	No	CBU_0517	29541120	aspB	aspartate aminotransferase [Coxiella bur...	394	Conserved; Drug target functions	Phase 3: June 2008	1BJW	43.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP02094 (show subtarget assignments)	1	cloned	No	STM3598	16766884		putative L-asparaginase [Salmonella typh...	347	Conserved; Drug target functions	Phase 3: June 2008	1ZCF	68.9%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP02497 (show subtarget assignments)	1	cloned	No	FTT1287	56708346	cbs	cystathionine beta-synthase (cystein syn...	307	Conserved; Drug target functions	Phase 3: June 2008	4AEC	33.2%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP01499 (show subtarget assignments)	1	cloned	No	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00171 (show subtarget assignments)	1	cloned	No	YPO0452	16120781	-	putative soluble lytic murein transglyco...	639	Similar to Essential SALTY	Phase 1: October 2007	1QSA	61.8%	Yersinia pestis	Hypothetical proteins	Conserved

IDP02066 (show subtarget assignments)	1	cloned	No	YPO1377	16121657	lolA	outer-membrane lipoprotein carrier prote...	202	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1IWL	66.3%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP04103 (show subtarget assignments)	1	cloned	No	YPO2280	218929372		putative phage-related secreted protein ...	414	putative drug target function;	Phase 4: April 2009			Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05129 (show subtarget assignments)	1	cloned	No	CD0091	126697661	adk	adenylate kinase [Clostridium difficile ...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3FB4	57.9%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP00417 (show subtarget assignments)	1	cloned	No	YPO2604	16122817	pbpA	penicillin-binding protein 2	631	Drug Target Function	Phase 2: March 2008	3OC2	26.1%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04106 (show subtarget assignments)	1	cloned	No	BAS0124	49183158		30S ribosomal protein S8 [Bacillus anthr...	132	Proposed to be essential proteins	Phase 4: April 2009	1SEI	85.6%	Bacillus anthracis

IDP05133 (show subtarget assignments)	1	cloned	No	CD0264	126697836	flhF	flagellar biosynthesis regulator FlhF [C...	338	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2J37	26%	Clostridium difficile	Protein fate: Protein and peptide secretion and trafficking

IDP05138 (show subtarget assignments)	1	cloned	No	CD2874	126700490		putative drug/sodium antiporter [Clostri...	446	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010			Clostridium difficile	Transport and binding proteins: Other

IDP02476 (show subtarget assignments)	1	cloned	No	YPO1776	16122030	dbpA	ATP-dependent RNA helicase DbpA [Yersini...	460	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2I4I	30%	Yersinia pestis	Transcription	Transcription factors

IDP02385 (show subtarget assignments)	1	cloned	No	Cj0755	15792094	cfrA	putative iron uptake protein [Campylobac...	696	Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate	Phase 3: June 2008	2HDF	29.8%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP01888 (show subtarget assignments)	1	cloned	No	GBAA5730	47531066	soJ	sporulation initiation inhibitor protein...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WCV	48.6%	Bacillus anthracis	Regulatory functions	Other

IDP05152 (show subtarget assignments)	1	cloned	No	BA_0420	30253954		conserved hypothetical protein [Bacillus...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP04112 (show subtarget assignments)	1	cloned	No	YPO2626	115348318	nagA	putative N-acetylglucosamine-6-phosphate...	381	drug target; putative drug target function;	Phase 4: April 2009	1YMY	75.1%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP02475 (show subtarget assignments)	1	cloned	No	GBAA3660	47528945		serine protease [Bacillus anthracis str....	413	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZLE	30%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01657 (show subtarget assignments)	1	cloned	No	YPO3061	16123238	dapX	lipoprotein [Yersinia pestis CO92]	352	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3TGO	56.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01653 (show subtarget assignments)	1	cloned	No	GBAA4538	47529835	dnaJ	chaperone protein dnaJ [Bacillus anthrac...	371	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3LZ8	34%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP00774 (show subtarget assignments)	1	cloned	No	SACOL0597	57285613		chaperone protein HchA	292	Drug Target Function	Phase 2: March 2008	1IZY	54.1%	Staphylococcus aureus	Hypothetical proteins	Conserved

IDP02478 (show subtarget assignments)	1	cloned	No	GBAA4182	47529478	pdhC	branched-chain alpha-keto acid dehydroge...	419	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	74.7%	Bacillus anthracis	Energy metabolism	Pyruvate dehydrogenase

IDP00173 (show subtarget assignments)	1	cloned	No	YPO2922	16123109	-	putative membrane protein	486	Virulence	Phase 1: October 2007	3K4U	14.4%	Yersinia pestis	Unknown function	General

IDP02075 (show subtarget assignments)	1	cloned	No	Cj0060c	15791452	fliM	flagellar motor switch protein FliM [Cam...	359	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3SOH	17%	Campylobacter jejuni	Cell envelope	Surface structures

IDP02074 (show subtarget assignments)	1	cloned	No	STM3149	16766449	hybA	hydrogenase 2 protein HybA [Salmonella t...	328	Conserved; Drug target functions	Phase 3: June 2008	1KQF	29.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02480 (show subtarget assignments)	1	cloned	No	GBAA5700	47531036	galE-2	UDP-glucose 4-epimerase [Bacillus anthra...	338	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3ENK	58.6%	Bacillus anthracis	Energy metabolism	Sugars

IDP01772 (show subtarget assignments)	1	cloned	No	YPO3599	16123741	clpB2	Clp ATPase [Yersinia pestis CO92]	867	Drug target motif; CD; Drug target functions	Phase 3: June 2008	1QVR	33.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01771 (show subtarget assignments)	1	cloned	No	YPO1786	16122040		hypothetical protein YPO1786 [Yersinia p...	118	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Cell envelope	Other

IDP00778 (show subtarget assignments)	1	cloned	No	SACOL0668	57284264		hydrolase, alpha/beta hydrolase fold fam...	266	Drug Target Function	Phase 2: March 2008	1VA4	26.1%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP01890 (show subtarget assignments)	1	cloned	No	Cj0063c	15791455		ATPase, ParA family [Campylobacter jejun...	288	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1HYQ	25.7%	Campylobacter jejuni	Cell envelope	Other

IDP01603 (show subtarget assignments)	1	cloned	No	STM1971	16765309	fliH	flagellar assembly protein H [Salmonella...	235	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00174 (show subtarget assignments)	1	cloned	No	YPO1140	16121437	-	putative membrane protein	272	Similar to Essential SALTY	Phase 1: October 2007			Yersinia pestis	Unknown function	General

IDP00714 (show subtarget assignments)	1	cloned	No	SACOL1198	57285941	ftsA	cell division protein FtsA	470	Drug Target Function	Phase 2: March 2008	1E4F	18.3%	Staphylococcus aureus	Cellular processes	Cell division

IDP01606 (show subtarget assignments)	1	cloned	No	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01608 (show subtarget assignments)	1	cloned	No	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	Phase 3: June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP00782 (show subtarget assignments)	1	cloned	No	SACOL0857	57284318		staphylocoagulase precursor, putative	508	Conserved Gene / Pathway	Phase 2: March 2008	2A1D	16.9%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP01777 (show subtarget assignments)	1	cloned	No	CBU_0313	29540926		transglycosylase, Slt family [Coxiella b...	487	Conserved; Drug target functions	Phase 3: June 2008	1QSA	9.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02083 (show subtarget assignments)	1	cloned	No	FTT1044c	56708131	ispB	octaprenyl-diphosphate synthase [Francis...	325	Drug Target	Phase 3: June 2008	3OYR	43.1%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP01612 (show subtarget assignments)	1	cloned	No	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02081 (show subtarget assignments)	1	cloned	No	Cj1340c	15792663		hypothetical protein Cj1340c [Campylobac...	605	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008			Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02485 (show subtarget assignments)	1	cloned	No	FTT1539c	56708571		hypothetical protein FTT1539c [Francisel...	476	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP05194 (show subtarget assignments)	1	cloned	No	CD0843	126698423		putative glycosyl transferase [Clostridi...	411	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2JJM	19.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05196 (show subtarget assignments)	1	cloned	No	CD0961	126698545		putative phage cell wall hydrolase [Clos...	656	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3H41	8.1%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP00176 (show subtarget assignments)	1	cloned	No	YPO4024	16124147	-	putative iron transport permease	335	Virulence	Phase 1: October 2007	2QI9	23.9%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01620 (show subtarget assignments)	1	cloned	No	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01621 (show subtarget assignments)	1	cloned	No	STM1984	16765321	yodD	putative cytoplasmic protein [Salmonella...	75	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01622 (show subtarget assignments)	1	cloned	No	STM4396	16767642	ytfB	putative cell envelope opacity-associate...	211	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01623 (show subtarget assignments)	1	cloned	No	GBAA5019	47530321	pckA	phosphoenolpyruvate carboxykinase [Bacil...	528	Conserved; Essential; Drug target functions	Phase 3: June 2008	1J3B	52.8%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP05202 (show subtarget assignments)	1	cloned	No	CD1700	126699306	ribD	riboflavin biosynthesis protein [Clostri...	367	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2HXV	41.4%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05205 (show subtarget assignments)	1	cloned	No	CD1770	126699379	ogt2	methylated-DNA--protein-cysteine methylt...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2G7H	32.3%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP01626 (show subtarget assignments)	1	cloned	No	GBAA5017	47530320	metK	S-adenosylmethionine synthetase [Bacillu...	399	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FUG	62.4%	Bacillus anthracis	Central intermediary metabolism	Other

IDP02382 (show subtarget assignments)	1	cloned	No	lmo0320	16802365		hypothetical protein lmo0320 [Listeria m...	399	Known virulence-Invasion; PMID:16015374	Phase 3: June 2008			Listeria monocytogenes	Cell envelope	Other

IDP04023 (show subtarget assignments)	1	cloned	No	YPO0511a	115346321		hypothetical protein [Yersinia pestis CO...	121	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP02424
(show subtarget assignments)

1

cloned

No

FTT1147c

56708218

dfp

4'-phosphopantothenoylcysteine decarboxy...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

19.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02423
(show subtarget assignments)

1

cloned

No

FTT1138

56708213

hemH

ferrochelatase [Francisella tularensis s...

333

Drug Target

Phase 3: June 2008

1HRK

27.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00165
(show subtarget assignments)

1

cloned

No

VC0844

15640861

acfA

accessory colonization factor AcfA

215

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01453
(show subtarget assignments)

1

cloned

No

VC2401

15642398

murG

N-acetylglucosaminyl transferase

354

Conserved Gene / Pathway

Phase 2: March 2008

1F0K

63.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05064
(show subtarget assignments)

1

cloned

No

CD2370

126699985

nadC

nicotinate-nucleotide pyrophosphorylase ...

270

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1X1O

46.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05066
(show subtarget assignments)

1

cloned

No

CD2654

126700268

mraY

phospho-N-acetylmuramoyl-pentapeptide-tr...

321

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04031
(show subtarget assignments)

1

cloned

No

CBU_A0011

29648123

hypothetical protein CBUA0011 [Coxiella ...

56

drug target;

Phase 4: April 2009

Coxiella burnetii

Hypothetical proteins

Domain

IDP01457
(show subtarget assignments)

1

cloned

No

VC2407

15642404

penicillin-binding protein 3

580

Drug Target Function

Phase 2: March 2008

3OC2

41.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00738
(show subtarget assignments)

1

cloned

No

SACOL0994

57284368

oppF

oligopeptide ABC transporter, ATP-bindin...

313

Drug Target Function

Phase 2: March 2008

2YZ2

27.2%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP04065
(show subtarget assignments)

1

cloned

No

CPF_2985

110800289

yyaC

putative sporulation protein YyaC [Clost...

196

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01460
(show subtarget assignments)

1

cloned

No

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP00406
(show subtarget assignments)

1

cloned

No

YPO3410

16123559

hypothetical protein YPO3410

115

Virulence Associated Factor

Phase 2: March 2008

3UTK

26.1%

Yersinia pestis

Cell envelope

Other

IDP00740
(show subtarget assignments)

1

cloned

No

SACOL1105

57285891

pdhD

dihydrolipoamide dehydrogenase

468

Drug Target Function

Phase 2: March 2008

1EBD

70.9%

Staphylococcus aureus

Energy metabolism

Pyruvate dehydrogenase

IDP01651
(show subtarget assignments)

1

cloned

No

YPO2946

16123129

clpB5

Clp ATPase [Yersinia pestis CO92]

891

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

1QVR

35.5%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04732
(show subtarget assignments)

1

cloned

No

BAS5341

49188325

50S ribosomal protein L34 [Bacillus anth...

44

Proposed to be essential proteins

Phase 4: April 2009

1NKW

65.9%

Bacillus anthracis

IDP02438
(show subtarget assignments)

1

cloned

No

CBU_0029

29540654

acyltransferase family protein [Coxiella...

242

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP01863
(show subtarget assignments)

1

cloned

No

GBAA5548

47778410

atpG

F0F1 ATP synthase subunit gamma [Bacillu...

286

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2QE7

58.7%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP04074
(show subtarget assignments)

1

cloned

No

BAS4469

49187464

50S ribosomal protein L20 [Bacillus anth...

118

Proposed to be essential proteins

Phase 4: April 2009

1VS6

55.1%

Bacillus anthracis

IDP00408
(show subtarget assignments)

1

cloned

No

YPO2735

16122939

ccmB

heme exporter protein B

219

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP02440
(show subtarget assignments)

1

cloned

No

lmo0331

16802376

hypothetical protein lmo0331 [Listeria m...

633

Predicted virulence-Invasion; Predicted involvement or location on the cell wall...

Phase 3: June 2008

3BZ5

28.4%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP02444
(show subtarget assignments)

1

cloned

No

YPO2224

16122453

hypothetical protein YPO2224 [Yersinia p...

103

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP04080
(show subtarget assignments)

1

cloned

No

BAS0123

49183157

30S ribosomal protein S14 [Bacillus anth...

61

Proposed to be essential proteins

Phase 4: April 2009

1FJG

73.8%

Bacillus anthracis

IDP01472
(show subtarget assignments)

1

cloned

No

VC2631

15642626

fimbrial assembly protein PilP, putative...

172

Conserved Gene / Pathway

Phase 2: March 2008

2LC4

16.3%

Vibrio cholerae

Cell envelope

Surface structures

IDP02052
(show subtarget assignments)

1

cloned

No

YPO2924

16123111

hypothetical protein YPO2924 [Yersinia p...

215

Conserved; Drug target functions

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP05082
(show subtarget assignments)

1

cloned

No

lmo2179

16804218

-

peptidoglycan binding protein [Listeria ...

1152

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KT7

2.3%

Listeria monocytogenes

Regulatory functions: Other

IDP01763
(show subtarget assignments)

1

cloned

No

YPO3627

16123769

ssuB

aliphatic sulfonates transport ATP-bindi...

271

Conserved; CD; Drug target functions

Phase 3: June 2008

2IT1

35.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00410
(show subtarget assignments)

1

cloned

No

YPO0548

16120876

ftsL

cell division protein FtsL

105

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Cell division

IDP04087
(show subtarget assignments)

1

cloned

No

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP02061
(show subtarget assignments)

1

cloned

No

CBU_0147

29540767

secA

preprotein translocase, SecA subunit [Co...

913

Conserved; Drug target functions

Phase 3: June 2008

2FSF

59.9%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02461
(show subtarget assignments)

1

cloned

No

Cj0176c

15791563

putative lipoprotein [Campylobacter jeju...

43

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Cations and iron carrying compounds

IDP01480
(show subtarget assignments)

1

cloned

No

VCA0116

15600887

clpB protein

869

Drug Target Function

Phase 2: March 2008

1QVR

36.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00168
(show subtarget assignments)

1

cloned

No

VC2209

15642774

vibF

nonribosomal peptide synthetase VibF, au...

2413

Virulence

Phase 1: October 2007

2VSQ

10.2%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP01764
(show subtarget assignments)

1

cloned

No

Cj1434c

15792752

putative sugar transferase [Campylobacte...

445

Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...

Phase 3: June 2008

3L7I

16.2%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02055
(show subtarget assignments)

1

cloned

No

Cj1327

15792650

neuB2

N-acetylneuraminic acid synthetase [Camp...

334

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...

Phase 3: June 2008

1VLI

36.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04092
(show subtarget assignments)

1

cloned

No

CPF_1925

110801017

spoVS

stage V sporulation protein S [Clostridi...

86

conserved gene; putative drug target function;

Phase 4: April 2009

2EH1

57%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01767
(show subtarget assignments)

1

cloned

No

Cj1436c

15792754

putative aminotransferase [Campylobacter...

390

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3FTB

25.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01766
(show subtarget assignments)

1

cloned

No

GBAA_pXO2_0063

47566732

ggt

gamma-glutamyltranspeptidase, (pxo2-55) ...

528

Drug target motif; Drug target homolog;

Phase 3: June 2008

3G9K

61.2%

Bacillus anthracis

N/A

IDP04091
(show subtarget assignments)

1

cloned

No

CPF_1278

110799680

putative lipoprotein [Clostridium perfri...

155

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP00753
(show subtarget assignments)

1

cloned

No

SACOL0052

57286607

glycosyl transferase, group 1 family pro...

503

Conserved Gene / Pathway

Phase 2: March 2008

2F9F

9.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP02464
(show subtarget assignments)

1

cloned

No

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP05106
(show subtarget assignments)

1

cloned

No

CD1469

126699073

cell surface protein (putative penicilli...

990

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2QMI

10%

Clostridium difficile

Cell envelope: Other

IDP05008
(show subtarget assignments)

1

cloned

No

CD1777

126699386

putative arsenate reductase [Clostridium...

120

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3FZ4

41.7%

Clostridium difficile

Cellular processes: Detoxification

IDP02471
(show subtarget assignments)

1

cloned

No

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP01775
(show subtarget assignments)

1

cloned

No

Cj1331

15792654

ptmB

acylneuraminate cytidylyltransferase (fl...

235

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...

Phase 3: June 2008

1EYR

28.9%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01495
(show subtarget assignments)

1

cloned

No

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02483
(show subtarget assignments)

1

cloned

No

CBU_0517

29541120

aspB

aspartate aminotransferase [Coxiella bur...

394

Conserved; Drug target functions

Phase 3: June 2008

1BJW

43.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP02094
(show subtarget assignments)

1

cloned

No

STM3598

16766884

putative L-asparaginase [Salmonella typh...

347

Conserved; Drug target functions

Phase 3: June 2008

1ZCF

68.9%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP02497
(show subtarget assignments)

1

cloned

No

FTT1287

56708346

cbs

cystathionine beta-synthase (cystein syn...

307

Conserved; Drug target functions

Phase 3: June 2008

4AEC

33.2%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP01499
(show subtarget assignments)

1

cloned

No

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00171
(show subtarget assignments)

1

cloned

No

YPO0452

16120781

-

putative soluble lytic murein transglyco...

639

Similar to Essential SALTY

Phase 1: October 2007

1QSA

61.8%

Yersinia pestis

Hypothetical proteins

Conserved

IDP02066
(show subtarget assignments)

1

cloned

No

YPO1377

16121657

lolA

outer-membrane lipoprotein carrier prote...

202

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1IWL

66.3%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP04103
(show subtarget assignments)

1

cloned

No

YPO2280

218929372

putative phage-related secreted protein ...

414

putative drug target function;

Phase 4: April 2009

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05129
(show subtarget assignments)

1

cloned

No

CD0091

126697661

adk

adenylate kinase [Clostridium difficile ...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3FB4

57.9%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP00417
(show subtarget assignments)

1

cloned

No

YPO2604

16122817

pbpA

penicillin-binding protein 2

631

Drug Target Function

Phase 2: March 2008

3OC2

26.1%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04106
(show subtarget assignments)

1

cloned

No

BAS0124

49183158

30S ribosomal protein S8 [Bacillus anthr...

132

Proposed to be essential proteins

Phase 4: April 2009

1SEI

85.6%

Bacillus anthracis

IDP05133
(show subtarget assignments)

1

cloned

No

CD0264

126697836

flhF

flagellar biosynthesis regulator FlhF [C...

338

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2J37

26%

Clostridium difficile

Protein fate: Protein and peptide secretion and trafficking

IDP05138
(show subtarget assignments)

1

cloned

No

CD2874

126700490

putative drug/sodium antiporter [Clostri...

446

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

Clostridium difficile

Transport and binding proteins: Other

IDP02476
(show subtarget assignments)

1

cloned

No

YPO1776

16122030

dbpA

ATP-dependent RNA helicase DbpA [Yersini...

460

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2I4I

30%

Yersinia pestis

Transcription

Transcription factors

IDP02385
(show subtarget assignments)

1

cloned

No

Cj0755

15792094

cfrA

putative iron uptake protein [Campylobac...

696

Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate

Phase 3: June 2008

2HDF

29.8%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP01888
(show subtarget assignments)

1

cloned

No

GBAA5730

47531066

soJ

sporulation initiation inhibitor protein...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WCV

48.6%

Bacillus anthracis

Regulatory functions

Other

IDP05152
(show subtarget assignments)

1

cloned

No

BA_0420

30253954

conserved hypothetical protein [Bacillus...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP04112
(show subtarget assignments)

1

cloned

No

YPO2626

115348318

nagA

putative N-acetylglucosamine-6-phosphate...

381

drug target; putative drug target function;

Phase 4: April 2009

1YMY

75.1%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP02475
(show subtarget assignments)

1

cloned

No

GBAA3660

47528945

serine protease [Bacillus anthracis str....

413

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZLE

30%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01657
(show subtarget assignments)

1

cloned

No

YPO3061

16123238

dapX

lipoprotein [Yersinia pestis CO92]

352

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3TGO

56.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01653
(show subtarget assignments)

1

cloned

No

GBAA4538

47529835

dnaJ

chaperone protein dnaJ [Bacillus anthrac...

371

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3LZ8

34%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP00774
(show subtarget assignments)

1

cloned

No

SACOL0597

57285613

chaperone protein HchA

292

Drug Target Function

Phase 2: March 2008

1IZY

54.1%

Staphylococcus aureus

Hypothetical proteins

Conserved

IDP02478
(show subtarget assignments)

1

cloned

No

GBAA4182

47529478

pdhC

branched-chain alpha-keto acid dehydroge...

419

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

74.7%

Bacillus anthracis

Energy metabolism

Pyruvate dehydrogenase

IDP00173
(show subtarget assignments)

1

cloned

No

YPO2922

16123109

-

putative membrane protein

486

Virulence

Phase 1: October 2007

3K4U

14.4%

Yersinia pestis

Unknown function

General

IDP02075
(show subtarget assignments)

1

cloned

No

Cj0060c

15791452

fliM

flagellar motor switch protein FliM [Cam...

359

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3SOH

17%

Campylobacter jejuni

Cell envelope

Surface structures

IDP02074
(show subtarget assignments)

1

cloned

No

STM3149

16766449

hybA

hydrogenase 2 protein HybA [Salmonella t...

328

Conserved; Drug target functions

Phase 3: June 2008

1KQF

29.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02480
(show subtarget assignments)

1

cloned

No

GBAA5700

47531036

galE-2

UDP-glucose 4-epimerase [Bacillus anthra...

338

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3ENK

58.6%

Bacillus anthracis

Energy metabolism

Sugars

IDP01772
(show subtarget assignments)

1

cloned

No

YPO3599

16123741

clpB2

Clp ATPase [Yersinia pestis CO92]

867

Drug target motif; CD; Drug target functions

Phase 3: June 2008

1QVR

33.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01771
(show subtarget assignments)

1

cloned

No

YPO1786

16122040

hypothetical protein YPO1786 [Yersinia p...

118

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Cell envelope

Other

IDP00778
(show subtarget assignments)

1

cloned

No

SACOL0668

57284264

hydrolase, alpha/beta hydrolase fold fam...

266

Drug Target Function

Phase 2: March 2008

1VA4

26.1%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP01890
(show subtarget assignments)

1

cloned

No

Cj0063c

15791455

ATPase, ParA family [Campylobacter jejun...

288

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1HYQ

25.7%

Campylobacter jejuni

Cell envelope

Other

IDP01603
(show subtarget assignments)

1

cloned

No

STM1971

16765309

fliH

flagellar assembly protein H [Salmonella...

235

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00174
(show subtarget assignments)

1

cloned

No

YPO1140

16121437

-

putative membrane protein

272

Similar to Essential SALTY

Phase 1: October 2007

Yersinia pestis

Unknown function

General

IDP00714
(show subtarget assignments)

1

cloned

No

SACOL1198

57285941

ftsA

cell division protein FtsA

470

Drug Target Function

Phase 2: March 2008

1E4F

18.3%

Staphylococcus aureus

Cellular processes

Cell division

IDP01606
(show subtarget assignments)

1

cloned

No

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01608
(show subtarget assignments)

1

cloned

No

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

Phase 3: June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP00782
(show subtarget assignments)

1

cloned

No

SACOL0857

57284318

staphylocoagulase precursor, putative

508

Conserved Gene / Pathway

Phase 2: March 2008

2A1D

16.9%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP01777
(show subtarget assignments)

1

cloned

No

CBU_0313

29540926

transglycosylase, Slt family [Coxiella b...

487

Conserved; Drug target functions

Phase 3: June 2008

1QSA

9.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02083
(show subtarget assignments)

1

cloned

No

FTT1044c

56708131

ispB

octaprenyl-diphosphate synthase [Francis...

325

Drug Target

Phase 3: June 2008

3OYR

43.1%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP01612
(show subtarget assignments)

1

cloned

No

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP02081
(show subtarget assignments)

1

cloned

No

Cj1340c

15792663

hypothetical protein Cj1340c [Campylobac...

605

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02485
(show subtarget assignments)

1

cloned

No

FTT1539c

56708571

hypothetical protein FTT1539c [Francisel...

476

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP05194
(show subtarget assignments)

1

cloned

No

CD0843

126698423

putative glycosyl transferase [Clostridi...

411

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2JJM

19.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05196
(show subtarget assignments)

1

cloned

No

CD0961

126698545

putative phage cell wall hydrolase [Clos...

656

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3H41

8.1%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP00176
(show subtarget assignments)

1

cloned

No

YPO4024

16124147

-

putative iron transport permease

335

Virulence

Phase 1: October 2007

2QI9

23.9%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01620
(show subtarget assignments)

1

cloned

No

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01621
(show subtarget assignments)

1

cloned

No

STM1984

16765321

yodD

putative cytoplasmic protein [Salmonella...

75

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01622
(show subtarget assignments)

1

cloned

No

STM4396

16767642

ytfB

putative cell envelope opacity-associate...

211

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01623
(show subtarget assignments)

1

cloned

No

GBAA5019

47530321

pckA

phosphoenolpyruvate carboxykinase [Bacil...

528

Conserved; Essential; Drug target functions

Phase 3: June 2008

1J3B

52.8%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP05202
(show subtarget assignments)

1

cloned

No

CD1700

126699306

ribD

riboflavin biosynthesis protein [Clostri...

367

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2HXV

41.4%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05205
(show subtarget assignments)

1

cloned

No

CD1770

126699379

ogt2

methylated-DNA--protein-cysteine methylt...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2G7H

32.3%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP01626
(show subtarget assignments)

1

cloned

No

GBAA5017

47530320

metK

S-adenosylmethionine synthetase [Bacillu...

399

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FUG

62.4%

Bacillus anthracis

Central intermediary metabolism

Other

IDP02382
(show subtarget assignments)

1

cloned

No

lmo0320

16802365

hypothetical protein lmo0320 [Listeria m...

399

Known virulence-Invasion; PMID:16015374

Phase 3: June 2008

Listeria monocytogenes

Cell envelope

Other

IDP04023
(show subtarget assignments)

1

cloned

No

YPO0511a

115346321

hypothetical protein [Yersinia pestis CO...

121

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved