Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04502 (show subtarget assignments)	1	purified	No	VC1136	9655608		amidotransferase HisH [Vibrio cholerae O...	203	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1KA9	36.9%	Vibrio cholerae	Amino acid biosynthesis	Histidine family

IDP05266 (show subtarget assignments)	1	purified	No	lmo0047	16802095	-	hypothetical protein lmo0047 [Listeria m...	203	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP01512 (show subtarget assignments)	1	soluble	No	VC1173	15641186		anthranilate synthase component II	203	Drug Target Function	Phase 2: March 2008	1I1Q	57.1%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP02656 (show subtarget assignments)	1	expressed	No	FTT0558	56707688		short chain dehydrogenase [Francisella t...	203	Drug Target	Phase 3: June 2008	3D7L	41.9%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP90806 (show subtarget assignments)	8	crystallized	No	S0665	30062173	phpB	alpha-ribazole phosphatase [Shigella fle...	203	Predicted Essential	Community Requests	3HJG	28.4%	Shigella flexneri

IDP05478 (show subtarget assignments)	1	cloned	No	BA_2933	30257525		putative lipoprotein [Bacillus anthracis...	203	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP90684 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1218c	15792542	ribA	riboflavin synthase subunit alpha [Campy...	203	Predicted Essential	Community Requests	1KZL	29.6%	Campylobacter jejuni

IDP02284 (show subtarget assignments)	1	soluble	No	CBU_1293	29541861	grpE	heat shock protein GrpE [Coxiella burnet...	204	Conserved; Drug target functions	Phase 3: June 2008	1DKG	35.3%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP02036 (show subtarget assignments)	1	cloned	No	GBAA1500	47526774		M23/37 family peptidase [Bacillus anthra...	204	Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...	Phase 3: June 2008	3SLU	23.5%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00102 (show subtarget assignments)	1	crystallized	No	NT01SF2944	30042031	evgA	putative positive transcription regulato...	204	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3F6C	64.7%	Shigella flexneri	Cell envelope	Surface structures

IDP04303 (show subtarget assignments)	1	cloned	No	CPF_0251	110800905	lacA	galactoside O-acetyltransferase [Clostri...	204	conserved gene; putative drug target function;	Phase 4: April 2009	1KQA	51%	Clostridium perfringens	Cellular processes	Detoxification

IDP01978 (show subtarget assignments)	1	cloned	No	STM3203	16766503	ygiM	putative signal transduction protein [Sa...	204	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP00333 (show subtarget assignments)	1	crystallized	No	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP04229 (show subtarget assignments)	1	purified	No	CPF_0676	110798651	purN	phosphoribosylglycinamide formyltransfer...	204	conserved gene; putative drug target function;	Phase 4: April 2009	2YWR	42.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01066 (show subtarget assignments)	1	expressed	No	STM3819	16767104	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP00515 (show subtarget assignments)	1	cloned	No	YPO3922	16124053		hemophore HasA	205	Virulence Associated Factor	Phase 2: March 2008	1B2V	29.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP91539 (show subtarget assignments)	8	selected	No	FTN_1290	118423781	mglA	macrophage growth locus, protein A [Fran...	205	virulence/pathogenesis / MglA regulates transcription of virulence factors necessary for Francisella tula...	Community Requests	3MDK	25.4%	Francisella novicida

IDP02139 (show subtarget assignments)	1	crystallized	No	GBAA4009	47529302	gmk	guanylate kinase [Bacillus anthracis str...	205	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3TAU	63.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP00863 (show subtarget assignments)	1	expressed	No	STM2254	16765582	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP05497 (show subtarget assignments)	1	cloned	No	CD0241	126697812		phosphoserine phosphatase [Clostridium d...	205	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5S	32.1%	Clostridium difficile	Amino acid biosynthesis: Serine family

IDP92042 (show subtarget assignments)	8	selected	No	TGME49_040590	237834761		DNA-directed RNA polymerases I, II, and ...	205	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3H0G	44%	Toxoplasma gondii

IDP01611 (show subtarget assignments)	1	in_pdb 3TAU	Yes	lmo1827	16803867	gmk	hypothetical protein lmo1827 [Listeria m...	205	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	3TAU	100%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02527 (show subtarget assignments)	1	in_pdb 3L4E	No	lmo0363	16802408		hypothetical protein lmo0363 [Listeria m...	205	Presence of Protease Motifs; DNA binding Motifs	Phase 3: June 2008	3L4E	100%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP04323 (show subtarget assignments)	1	in_pdb 3OT1	No	VC2308	15642306		4-methyl-5(B-hydroxyethyl)-thiazole mono...	205	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3OT1	100%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP02828 (show subtarget assignments)	1	cloned	No	GBAA4243	47529536		hypothetical protein GBAA4243 [Bacillus ...	205	Drug target motif;	Phase 3: June 2008			Bacillus anthracis	N/A	N/A

IDP05424 (show subtarget assignments)	1	cloned	No	lmo0438	16802482	-	hypothetical protein lmo0438 [Listeria m...	192	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2XL4	89.1%	Listeria monocytogenes

IDP91216 (show subtarget assignments)	1	crystallized	No	FTT_1275	56708335	mglA	macrophage growth locus, subunit A [Fran...	205	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3MDK	25.4%	Francisella tularensis

IDP01327 (show subtarget assignments)	1	purified	No	VC0418	15640445	maf	Maf-like protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	40%	Vibrio cholerae	Cellular processes	Cell division

IDP02162 (show subtarget assignments)	1	cloned	No	FTT1463c	56708504	wbtB	galactosyl transferase [Francisella tula...	205	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP04051 (show subtarget assignments)	1	expressed	No	YPO0511	115346320		hypothetical protein [Yersinia pestis CO...	205	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP01117 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3754	33301235		LexA repressor	206	Conserved Gene / Pathway	Phase 2: March 2008	3K2Z	38.3%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP01085 (show subtarget assignments)	1	in_crystallization_trials	No	STM4397	161353572	fklB	FKBP-type 22KD peptidyl-prolyl cis-trans...	206	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.3%	Salmonella enterica	Protein synthesis	Translation factors

IDP91061 (show subtarget assignments)	8	purified	No	YPO3532	16123678	fklB	FKBP-type peptidyl-prolyl cis-trans isom...	206	virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...	Community Requests	1FD9	38.8%	Yersinia pestis

IDP04279 (show subtarget assignments)	1	expressed	No	YPO0260	218927465		putative AraC-family regulatory protein ...	206	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	3OIO	16.5%	Yersinia pestis	Regulatory functions	Other

IDP00907 (show subtarget assignments)	1	in_crystallization_trials	No	STM0140	16763530	coaE	dephospho-CoA kinase	206	Conserved Gene / Pathway	Phase 2: March 2008	1N3B	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP91008 (show subtarget assignments)	8	soluble	No	y1951	22125843	sodB	superoxide dismutase [Yersinia pestis KI...	206	other biological interest / iron-regulated oxidative stress enzyme	Community Requests	1ISA	75.2%	Yersinia pestis

IDP91756 (show subtarget assignments)	8	selected	No	VF01_VACCP	0			206	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2VTY	81.1%	Vaccinia virus

IDP01421 (show subtarget assignments)	1	soluble	No	VC1544	15641552		tonB2 protein	206	Conserved Gene / Pathway	Phase 2: March 2008	2K9K	34%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05237 (show subtarget assignments)	1	soluble	No	lmo1653	16803693	-	putative cellsurface protein [Listeria m...	201	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP04485 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3430	115349058		conserved hypothetical protein [Yersinia...	206	conserved gene; putative drug target function;	Phase 4: April 2009	1N3B	62.1%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05698 (show subtarget assignments)	1	cloned	No	lmo2186	16804225	-	hypothetical protein lmo2186 [Listeria m...	207	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2O6P	26.1%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP00510 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3572	16123716		hypothetical protein YPO3572	207	Virulence Associated Factor	Phase 2: March 2008	2QGU	30%	Yersinia pestis	Cell envelope	Other

IDP04583 (show subtarget assignments)	1	cloned	No	BAS0111	49183145		50S ribosomal protein L4 [Bacillus anthr...	207	Proposed to be essential proteins	Phase 4: April 2009	1DMG	47.1%	Bacillus anthracis

IDP01510 (show subtarget assignments)	1	in_crystallization_trials	No	VC0731	15640750		antioxidant, AhpC/Tsa family	207	Conserved Gene / Pathway	Phase 2: March 2008	1ZOF	55.1%	Vibrio cholerae	Cellular processes	Detoxification

IDP90623 (show subtarget assignments)	8	purified	No	Cj1177c	15792501	gmk	guanylate kinase [Campylobacter jejuni s...	207	Predicted Essential	Community Requests	1S96	39.1%	Campylobacter jejuni

IDP91338 (show subtarget assignments)	8	expressed	No	VV2_0132	27366588		cytochrome c553 [Vibrio vulnificus CMCP6...	207	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1FCD	27.5%	Vibrio vulnificus

IDP91596 (show subtarget assignments)	8	selected	No	AAD02118	4104708	vanXst	D-ala-D-ala dipeptidase [Streptomyces to...	208	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1R44	62%	Streptomyces toyocaensis

IDP02667 (show subtarget assignments)	1	cloned	No	lmo0565	16802608	hisH	imidazole glycerol phosphate synthase su...	208	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	1OX4	33.5%	Listeria monocytogenes	Amino acid biosynthesis	Histidine family

IDP05611 (show subtarget assignments)	1	expressed	No	BA_5156	30259642		conserved hypothetical protein [Bacillus...	208	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP00943 (show subtarget assignments)	1	crystallized	No	STM0862	16764224	yliJ	putative glutathione S-transferase	208	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	30.8%	Salmonella enterica	Cellular processes	Detoxification

IDP02510 (show subtarget assignments)	1	expressed	No	YPO2285	16122509		putative ribose-binding periplasmic prot...	208	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	35.6%	Yersinia pestis	N/A	N/A

IDP00878 (show subtarget assignments)	1	expressed	No	STM4306	16767556		putative anaerobic dimethylsulfoxide red...	208	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	29.3%	Salmonella enterica	Energy metabolism	Anaerobic

IDP04265 (show subtarget assignments)	1	purified	No	CPF_2105	110800754		putative cell division protein DivIVA [C...	208	conserved gene; putative drug target function;	Phase 4: April 2009	2WUJ	12%	Clostridium perfringens	Cellular processes	Cell division

IDP02311 (show subtarget assignments)	1	in_pdb 3MJD	Yes	FTT0437c	56707581	pyrE	orotate phosphoribosyltransferase [Franc...	208	Drug Target	Phase 3: June 2008	3MJD	100%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90384 (show subtarget assignments)	8	in_crystallization_trials	No	CT_360	3328783		hypothetical protein [Chlamydia trachoma...	208	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP90550 (show subtarget assignments)	8	purified	No	Cj1594	15792899	rpsD	30S ribosomal protein S4 [Campylobacter ...	208	Predicted Essential	Community Requests	1VS5	50.7%	Campylobacter jejuni

IDP00651 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0143	57285346	cap5H	capsular polysaccharide biosynthesis pro...	208	Conserved Gene / Pathway	Phase 2: March 2008	3EEV	33.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91491 (show subtarget assignments)	8	crystallized	No	VP1692	28898466		putative type III export protein [Vibrio...	208	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP04035 (show subtarget assignments)	1	in_pdb 3P0R	Yes	BAS5262	49188247		azoreductase [Bacillus anthracis str. St...	208	Proposed to be essential proteins	Phase 4: April 2009	3P0R	100%	Bacillus anthracis

IDP04011 (show subtarget assignments)	1	cloned	No	CPF_2475	110800353		stage II sporulation protein R [Clostrid...	209	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05317 (show subtarget assignments)	1	cloned	No	lmo0638	16802680	-	hypothetical protein lmo0638 [Listeria m...	209	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP01006 (show subtarget assignments)	1	soluble	No	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP91574 (show subtarget assignments)	8	soluble	No	BAB35578	13361621	ECs2155	hypothetical protein [Escherichia coli O...	209	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	19.6%	Escherichia coli

IDP02518 (show subtarget assignments)	1	purified	No	GBAA5557	47530877	upp	uracil phosphoribosyltransferase [Bacill...	209	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1I5E	84.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01844 (show subtarget assignments)	1	soluble	No	GBAA1428	47526700	hisH	imidazole glycerol phosphate synthase su...	209	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GPW	35.9%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02246 (show subtarget assignments)	1	expressed	No	FTT0649c	56707771	rnfB	Iron-sulfur cluster-binding protein [Fra...	209	Drug Target	Phase 3: June 2008	1GT8	12.9%	Francisella tularensis	Energy metabolism	Electron transport

IDP01624 (show subtarget assignments)	1	expressed	No	CBU_1879	29542436		polypeptide deformylase, putative [Coxie...	209	Conserved; Drug target functions	Phase 3: June 2008	1LM6	29.2%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP91633 (show subtarget assignments)	8	purified	No	BAB35418	13361460	ECs1995	hypothetical protein [Escherichia coli O...	209	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2KKX	20.1%	Escherichia coli

IDP05121 (show subtarget assignments)	1	purified	No	BA_0915	30254659		conserved hypothetical protein [Bacillus...	209	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP00413 (show subtarget assignments)	1	soluble	No	YPCD1.60	16082748	yscK	type III secretion apparatus component	209	Virulence Associated Factor	Phase 2: March 2008			Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01469 (show subtarget assignments)	1	purified	No	VC2568	15642563		peptidyl-prolyl cis-trans isomerase, FKB...	209	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01350 (show subtarget assignments)	1	in_pdb 3EEV	No	VCA0300	15601065		chloramphenicol acetyltransferase	209	Drug Target Function	Phase 2: March 2008	3EEV	100%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP90946 (show subtarget assignments)	8	cloned	No	BP1878	33592926	bvgA	virulence factors transcription regulato...	209	BvgA is the transcriptional activator for all known virulence genes in the human...	Community Requests	3C3W	31.6%	Bordetella pertussis

IDP01712 (show subtarget assignments)	1	in_pdb 3EFE	No	GBAA2657	47551781		thiJ/pfpI family protein [Bacillus anthr...	210	CONSERVED	Phase 3: June 2008	3EFE	100%	Bacillus anthracis	N/A	N/A

IDP05322 (show subtarget assignments)	1	cloned	No	CD3430	126701053	cbiC	cobalt-precorrin-8X methylmutase [Clostr...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AFR	41.9%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05512 (show subtarget assignments)	1	cloned	No	CD1601	126699205	thiE1	thiamine-phosphate pyrophosphorylase [Cl...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XI3	41%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP04066 (show subtarget assignments)	8	selected	No	CAC05819	12329088	mxiE	MxiE, similarities to transcriptional ac...	210	Shigella effector protein	Community Requests			Shigella flexneri

IDP91810 (show subtarget assignments)	8	soluble	No	b3357	1789756	crp	DNA-binding transcriptional dual regulat...	210	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1G6N	100%	Escherichia coli

IDP91217 (show subtarget assignments)	1	expressed	No	FTT_0458	56707600	sspA	stringent starvation protein A, regulato...	210	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LYK	31.4%	Francisella tularensis

IDP00043 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2629	30257246		acetyltransferase, CYSE/LACA/LPXA/NODL f...	210	Virulence	Phase 1: October 2007	4E8L	63.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP04423 (show subtarget assignments)	1	in_pdb 3M3H 3OSC	Yes	GBAA4021	47529314	pyrE	orotate phosphoribosyltransferase [Bacil...	210	conserved gene; putative drug target function;	Phase 4: April 2009	3M3H	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90143 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_189	68449260		bifunctional IL-1-beta-inhibitor/prevent...	210	contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184	Community Requests	3O4O	29.5%	Monkeypox virus

IDP91540 (show subtarget assignments)	8	selected	No	FTN_0549	118423054	sspA	stringent starvation protein A [Francise...	210	virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.	Community Requests	3LYK	31.4%	Francisella novicida

IDP91326 (show subtarget assignments)	8	soluble	No	VV2_0291	27366737		chaperonin GroEL [Vibrio vulnificus CMCP...	210	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91193 (show subtarget assignments)	8	cloned	No	BAS4092	49187090	-	Stage III sporulation protein AF	210	essential/virulence/pathogenesis / Essential proteins	Community Requests			Bacillus anthracis

IDP04582 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0110	49183144		50S ribosomal protein L3 [Bacillus anthr...	210	Proposed to be essential proteins	Phase 4: April 2009	1NKW	53.3%	Bacillus anthracis

IDP04507 (show subtarget assignments)	1	crystallized	No	VCA1079	9658525		pyridoxamine 5`-phosphate oxidase [Vibri...	211	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1G76	65.9%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02488 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1425	47526697	hisG	ATP phosphoribosyltransferase catalytic ...	211	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1Z7M	49.8%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP00211 (show subtarget assignments)	1	purified	No	YPO2101	16122340	-	hypothetical phage protein	211	Virulence	Phase 1: October 2007			Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP01622 (show subtarget assignments)	1	cloned	No	STM4396	16767642	ytfB	putative cell envelope opacity-associate...	211	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01516 (show subtarget assignments)	1	crystallized	No	VC0576	15640598	sspA	stringent starvation protein A	211	Conserved Gene / Pathway	Phase 2: March 2008	1YY7	73.9%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP01990 (show subtarget assignments)	0	work_stopped	No	Cj1435c	15792753		hypothetical protein Cj1435c [Campylobac...	211	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	3FVV	26.1%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01447 (show subtarget assignments)	1	in_crystallization_trials	No	VC2181	15642180	lolB	outer membrane lipoprotein LolB	211	Conserved Gene / Pathway	Phase 2: March 2008	1IWM	30.3%	Vibrio cholerae	Cell envelope	Other

IDP02365 (show subtarget assignments)	1	purified	No	FTT0403	56707552	def1	peptide deformylase [Francisella tularen...	211	Conserved; Drug target functions	Phase 3: June 2008	3M6O	28.4%	Francisella tularensis	Protein fate	Protein modification and repair

IDP91355 (show subtarget assignments)	8	soluble	No	VV1_3022	27366292		cob(I)yrinic acid a,c-diamide adenosyltr...	211	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1G5R	59.2%	Vibrio vulnificus

IDP04087 (show subtarget assignments)	1	cloned	No	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP90994 (show subtarget assignments)	8	purified	No	y1355	22125254		hypothetical protein y1355 [Yersinia pes...	211	other biological interest / -	Community Requests			Yersinia pestis

IDP05261 (show subtarget assignments)	1	cloned	No	CD2772	126700388	tuaG	putative teichuronic acid biosynthesis g...	212	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3BCV	23.6%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00455 (show subtarget assignments)	1	purified	No	YPO3080	16123257	tesA	multifunctional acyl-CoA thioesterase I ...	212	Conserved Gene / Pathway	Phase 2: March 2008	1IVN	60.4%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00836 (show subtarget assignments)	1	in_pdb 3GIU	No	SACOL2714	57285268	pcp	pyrrolidone-carboxylate peptidase	212	Drug Target Function	Phase 2: March 2008	3GIU	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04502
(show subtarget assignments)

1

purified

No

VC1136

9655608

amidotransferase HisH [Vibrio cholerae O...

203

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1KA9

36.9%

Vibrio cholerae

Amino acid biosynthesis

Histidine family

IDP05266
(show subtarget assignments)

1

purified

No

lmo0047

16802095

-

hypothetical protein lmo0047 [Listeria m...

203

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP01512
(show subtarget assignments)

1

soluble

No

VC1173

15641186

anthranilate synthase component II

203

Drug Target Function

Phase 2: March 2008

1I1Q

57.1%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP02656
(show subtarget assignments)

1

expressed

No

FTT0558

56707688

short chain dehydrogenase [Francisella t...

203

Drug Target

Phase 3: June 2008

3D7L

41.9%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP90806
(show subtarget assignments)

8

crystallized

No

S0665

30062173

phpB

alpha-ribazole phosphatase [Shigella fle...

203

Predicted Essential

Community Requests

3HJG

28.4%

Shigella flexneri

IDP05478
(show subtarget assignments)

1

cloned

No

BA_2933

30257525

putative lipoprotein [Bacillus anthracis...

203

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP90684
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1218c

15792542

ribA

riboflavin synthase subunit alpha [Campy...

203

Predicted Essential

Community Requests

1KZL

29.6%

Campylobacter jejuni

IDP02284
(show subtarget assignments)

1

soluble

No

CBU_1293

29541861

grpE

heat shock protein GrpE [Coxiella burnet...

204

Conserved; Drug target functions

Phase 3: June 2008

1DKG

35.3%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP02036
(show subtarget assignments)

1

cloned

No

GBAA1500

47526774

M23/37 family peptidase [Bacillus anthra...

204

Drug target motif; Involved in sporulation; Vaccine Target; Drug target function...

Phase 3: June 2008

3SLU

23.5%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00102
(show subtarget assignments)

1

crystallized

No

NT01SF2944

30042031

evgA

putative positive transcription regulato...

204

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3F6C

64.7%

Shigella flexneri

Cell envelope

Surface structures

IDP04303
(show subtarget assignments)

1

cloned

No

CPF_0251

110800905

lacA

galactoside O-acetyltransferase [Clostri...

204

conserved gene; putative drug target function;

Phase 4: April 2009

1KQA

51%

Clostridium perfringens

Cellular processes

Detoxification

IDP01978
(show subtarget assignments)

1

cloned

No

STM3203

16766503

ygiM

putative signal transduction protein [Sa...

204

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP00333
(show subtarget assignments)

1

crystallized

No

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP04229
(show subtarget assignments)

1

purified

No

CPF_0676

110798651

purN

phosphoribosylglycinamide formyltransfer...

204

conserved gene; putative drug target function;

Phase 4: April 2009

2YWR

42.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01066
(show subtarget assignments)

1

expressed

No

STM3819

16767104

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP00515
(show subtarget assignments)

1

cloned

No

YPO3922

16124053

hemophore HasA

205

Virulence Associated Factor

Phase 2: March 2008

1B2V

29.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP91539
(show subtarget assignments)

8

selected

No

FTN_1290

118423781

mglA

macrophage growth locus, protein A [Fran...

205

virulence/pathogenesis / MglA regulates transcription of virulence factors necessary for Francisella tula...

Community Requests

3MDK

25.4%

Francisella novicida

IDP02139
(show subtarget assignments)

1

crystallized

No

GBAA4009

47529302

gmk

guanylate kinase [Bacillus anthracis str...

205

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3TAU

63.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP00863
(show subtarget assignments)

1

expressed

No

STM2254

16765582

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP05497
(show subtarget assignments)

1

cloned

No

CD0241

126697812

phosphoserine phosphatase [Clostridium d...

205

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5S

32.1%

Clostridium difficile

Amino acid biosynthesis: Serine family

IDP92042
(show subtarget assignments)

8

selected

No

TGME49_040590

237834761

DNA-directed RNA polymerases I, II, and ...

205

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3H0G

44%

Toxoplasma gondii

IDP01611
(show subtarget assignments)

1

in_pdb
3TAU

Yes

lmo1827

16803867

gmk

hypothetical protein lmo1827 [Listeria m...

205

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

3TAU

100%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02527
(show subtarget assignments)

1

in_pdb
3L4E

No

lmo0363

16802408

hypothetical protein lmo0363 [Listeria m...

205

Presence of Protease Motifs; DNA binding Motifs

Phase 3: June 2008

3L4E

100%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP04323
(show subtarget assignments)

1

in_pdb
3OT1

No

VC2308

15642306

4-methyl-5(B-hydroxyethyl)-thiazole mono...

205

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3OT1

100%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP02828
(show subtarget assignments)

1

cloned

No

GBAA4243

47529536

hypothetical protein GBAA4243 [Bacillus ...

205

Drug target motif;

Phase 3: June 2008

Bacillus anthracis

N/A

IDP05424
(show subtarget assignments)

1

cloned

No

lmo0438

16802482

-

hypothetical protein lmo0438 [Listeria m...

192

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2XL4

89.1%

Listeria monocytogenes

IDP91216
(show subtarget assignments)

1

crystallized

No

FTT_1275

56708335

mglA

macrophage growth locus, subunit A [Fran...

205

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3MDK

25.4%

Francisella tularensis

IDP01327
(show subtarget assignments)

1

purified

No

VC0418

15640445

maf

Maf-like protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

40%

Vibrio cholerae

Cellular processes

Cell division

IDP02162
(show subtarget assignments)

1

cloned

No

FTT1463c

56708504

wbtB

galactosyl transferase [Francisella tula...

205

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP04051
(show subtarget assignments)

1

expressed

No

YPO0511

115346320

hypothetical protein [Yersinia pestis CO...

205

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP01117
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3754

33301235

LexA repressor

206

Conserved Gene / Pathway

Phase 2: March 2008

3K2Z

38.3%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP01085
(show subtarget assignments)

1

in_crystallization_trials

No

STM4397

161353572

fklB

FKBP-type 22KD peptidyl-prolyl cis-trans...

206

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.3%

Salmonella enterica

Protein synthesis

Translation factors

IDP91061
(show subtarget assignments)

8

purified

No

YPO3532

16123678

fklB

FKBP-type peptidyl-prolyl cis-trans isom...

206

virulence/pathogenesis / Gene encodes a Mip orthologue which has shown to be important for virulence in v...

Community Requests

1FD9

38.8%

Yersinia pestis

IDP04279
(show subtarget assignments)

1

expressed

No

YPO0260

218927465

putative AraC-family regulatory protein ...

206

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

3OIO

16.5%

Yersinia pestis

Regulatory functions

Other

IDP00907
(show subtarget assignments)

1

in_crystallization_trials

No

STM0140

16763530

coaE

dephospho-CoA kinase

206

Conserved Gene / Pathway

Phase 2: March 2008

1N3B

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP91008
(show subtarget assignments)

8

soluble

No

y1951

22125843

sodB

superoxide dismutase [Yersinia pestis KI...

206

other biological interest / iron-regulated oxidative stress enzyme

Community Requests

1ISA

75.2%

Yersinia pestis

IDP91756
(show subtarget assignments)

8

selected

No

VF01_VACCP

0

206

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2VTY

81.1%

Vaccinia virus

IDP01421
(show subtarget assignments)

1

soluble

No

VC1544

15641552

tonB2 protein

206

Conserved Gene / Pathway

Phase 2: March 2008

2K9K

34%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05237
(show subtarget assignments)

1

soluble

No

lmo1653

16803693

-

putative cellsurface protein [Listeria m...

201

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP04485
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3430

115349058

conserved hypothetical protein [Yersinia...

206

conserved gene; putative drug target function;

Phase 4: April 2009

1N3B

62.1%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05698
(show subtarget assignments)

1

cloned

No

lmo2186

16804225

-

hypothetical protein lmo2186 [Listeria m...

207

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2O6P

26.1%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP00510
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3572

16123716

hypothetical protein YPO3572

207

Virulence Associated Factor

Phase 2: March 2008

2QGU

30%

Yersinia pestis

Cell envelope

Other

IDP04583
(show subtarget assignments)

1

cloned

No

BAS0111

49183145

50S ribosomal protein L4 [Bacillus anthr...

207

Proposed to be essential proteins

Phase 4: April 2009

1DMG

47.1%

Bacillus anthracis

IDP01510
(show subtarget assignments)

1

in_crystallization_trials

No

VC0731

15640750

antioxidant, AhpC/Tsa family

207

Conserved Gene / Pathway

Phase 2: March 2008

1ZOF

55.1%

Vibrio cholerae

Cellular processes

Detoxification

IDP90623
(show subtarget assignments)

8

purified

No

Cj1177c

15792501

gmk

guanylate kinase [Campylobacter jejuni s...

207

Predicted Essential

Community Requests

1S96

39.1%

Campylobacter jejuni

IDP91338
(show subtarget assignments)

8

expressed

No

VV2_0132

27366588

cytochrome c553 [Vibrio vulnificus CMCP6...

207

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1FCD

27.5%

Vibrio vulnificus

IDP91596
(show subtarget assignments)

8

selected

No

AAD02118

4104708

vanXst

D-ala-D-ala dipeptidase [Streptomyces to...

208

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1R44

62%

Streptomyces toyocaensis

IDP02667
(show subtarget assignments)

1

cloned

No

lmo0565

16802608

hisH

imidazole glycerol phosphate synthase su...

208

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

1OX4

33.5%

Listeria monocytogenes

Amino acid biosynthesis

Histidine family

IDP05611
(show subtarget assignments)

1

expressed

No

BA_5156

30259642

conserved hypothetical protein [Bacillus...

208

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP00943
(show subtarget assignments)

1

crystallized

No

STM0862

16764224

yliJ

putative glutathione S-transferase

208

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

30.8%

Salmonella enterica

Cellular processes

Detoxification

IDP02510
(show subtarget assignments)

1

expressed

No

YPO2285

16122509

putative ribose-binding periplasmic prot...

208

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

35.6%

Yersinia pestis

N/A

IDP00878
(show subtarget assignments)

1

expressed

No

STM4306

16767556

putative anaerobic dimethylsulfoxide red...

208

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

29.3%

Salmonella enterica

Energy metabolism

Anaerobic

IDP04265
(show subtarget assignments)

1

purified

No

CPF_2105

110800754

putative cell division protein DivIVA [C...

208

conserved gene; putative drug target function;

Phase 4: April 2009

2WUJ

12%

Clostridium perfringens

Cellular processes

Cell division

IDP02311
(show subtarget assignments)

1

in_pdb
3MJD

Yes

FTT0437c

56707581

pyrE

orotate phosphoribosyltransferase [Franc...

208

Drug Target

Phase 3: June 2008

3MJD

100%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90384
(show subtarget assignments)

8

in_crystallization_trials

No

CT_360

3328783

hypothetical protein [Chlamydia trachoma...

208

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP90550
(show subtarget assignments)

8

purified

No

Cj1594

15792899

rpsD

30S ribosomal protein S4 [Campylobacter ...

208

Predicted Essential

Community Requests

1VS5

50.7%

Campylobacter jejuni

IDP00651
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0143

57285346

cap5H

capsular polysaccharide biosynthesis pro...

208

Conserved Gene / Pathway

Phase 2: March 2008

3EEV

33.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91491
(show subtarget assignments)

8

crystallized

No

VP1692

28898466

putative type III export protein [Vibrio...

208

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP04035
(show subtarget assignments)

1

in_pdb
3P0R

Yes

BAS5262

49188247

azoreductase [Bacillus anthracis str. St...

208

Proposed to be essential proteins

Phase 4: April 2009

3P0R

100%

Bacillus anthracis

IDP04011
(show subtarget assignments)

1

cloned

No

CPF_2475

110800353

stage II sporulation protein R [Clostrid...

209

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05317
(show subtarget assignments)

1

cloned

No

lmo0638

16802680

-

hypothetical protein lmo0638 [Listeria m...

209

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP01006
(show subtarget assignments)

1

soluble

No

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic

IDP91574
(show subtarget assignments)

8

soluble

No

BAB35578

13361621

ECs2155

hypothetical protein [Escherichia coli O...

209

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

19.6%

Escherichia coli

IDP02518
(show subtarget assignments)

1

purified

No

GBAA5557

47530877

upp

uracil phosphoribosyltransferase [Bacill...

209

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1I5E

84.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01844
(show subtarget assignments)

1

soluble

No

GBAA1428

47526700

hisH

imidazole glycerol phosphate synthase su...

209

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GPW

35.9%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02246
(show subtarget assignments)

1

expressed

No

FTT0649c

56707771

rnfB

Iron-sulfur cluster-binding protein [Fra...

209

Drug Target

Phase 3: June 2008

1GT8

12.9%

Francisella tularensis

Energy metabolism

Electron transport

IDP01624
(show subtarget assignments)

1

expressed

No

CBU_1879

29542436

polypeptide deformylase, putative [Coxie...

209

Conserved; Drug target functions

Phase 3: June 2008

1LM6

29.2%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP91633
(show subtarget assignments)

8

purified

No

BAB35418

13361460

ECs1995

hypothetical protein [Escherichia coli O...

209

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2KKX

20.1%

Escherichia coli

IDP05121
(show subtarget assignments)

1

purified

No

BA_0915

30254659

conserved hypothetical protein [Bacillus...

209

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP00413
(show subtarget assignments)

1

soluble

No

YPCD1.60

16082748

yscK

type III secretion apparatus component

209

Virulence Associated Factor

Phase 2: March 2008

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01469
(show subtarget assignments)

1

purified

No

VC2568

15642563

peptidyl-prolyl cis-trans isomerase, FKB...

209

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01350
(show subtarget assignments)

1

in_pdb
3EEV

No

VCA0300

15601065

chloramphenicol acetyltransferase

209

Drug Target Function

Phase 2: March 2008

3EEV

100%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP90946
(show subtarget assignments)

8

cloned

No

BP1878

33592926

bvgA

virulence factors transcription regulato...

209

BvgA is the transcriptional activator for all known virulence genes in the human...

Community Requests

3C3W

31.6%

Bordetella pertussis

IDP01712
(show subtarget assignments)

1

in_pdb
3EFE

No

GBAA2657

47551781

thiJ/pfpI family protein [Bacillus anthr...

210

CONSERVED

Phase 3: June 2008

3EFE

100%

Bacillus anthracis

N/A

IDP05322
(show subtarget assignments)

1

cloned

No

CD3430

126701053

cbiC

cobalt-precorrin-8X methylmutase [Clostr...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AFR

41.9%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05512
(show subtarget assignments)

1

cloned

No

CD1601

126699205

thiE1

thiamine-phosphate pyrophosphorylase [Cl...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XI3

41%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP04066
(show subtarget assignments)

8

selected

No

CAC05819

12329088

mxiE

MxiE, similarities to transcriptional ac...

210

Shigella effector protein

Community Requests

Shigella flexneri

IDP91810
(show subtarget assignments)

8

soluble

No

b3357

1789756

crp

DNA-binding transcriptional dual regulat...

210

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1G6N

100%

Escherichia coli

IDP91217
(show subtarget assignments)

1

expressed

No

FTT_0458

56707600

sspA

stringent starvation protein A, regulato...

210

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LYK

31.4%

Francisella tularensis

IDP00043
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2629

30257246

acetyltransferase, CYSE/LACA/LPXA/NODL f...

210

Virulence

Phase 1: October 2007

4E8L

63.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP04423
(show subtarget assignments)

1

in_pdb
3M3H
3OSC

Yes

GBAA4021

47529314

pyrE

orotate phosphoribosyltransferase [Bacil...

210

conserved gene; putative drug target function;

Phase 4: April 2009

3M3H

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90143
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_189

68449260

bifunctional IL-1-beta-inhibitor/prevent...

210

contains IG fold, similar to VACV-WR-197, MPXV-ZAR_1979_005-184

Community Requests

3O4O

29.5%

Monkeypox virus

IDP91540
(show subtarget assignments)

8

selected

No

FTN_0549

118423054

sspA

stringent starvation protein A [Francise...

210

virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.

Community Requests

3LYK

31.4%

Francisella novicida

IDP91326
(show subtarget assignments)

8

soluble

No

VV2_0291

27366737

chaperonin GroEL [Vibrio vulnificus CMCP...

210

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91193
(show subtarget assignments)

8

cloned

No

BAS4092

49187090

-

Stage III sporulation protein AF

210

essential/virulence/pathogenesis / Essential proteins

Community Requests

Bacillus anthracis

IDP04582
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0110

49183144

50S ribosomal protein L3 [Bacillus anthr...

210

Proposed to be essential proteins

Phase 4: April 2009

1NKW

53.3%

Bacillus anthracis

IDP04507
(show subtarget assignments)

1

crystallized

No

VCA1079

9658525

pyridoxamine 5`-phosphate oxidase [Vibri...

211

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1G76

65.9%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02488
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1425

47526697

hisG

ATP phosphoribosyltransferase catalytic ...

211

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1Z7M

49.8%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP00211
(show subtarget assignments)

1

purified

No

YPO2101

16122340

-

hypothetical phage protein

211

Virulence

Phase 1: October 2007

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP01622
(show subtarget assignments)

1

cloned

No

STM4396

16767642

ytfB

putative cell envelope opacity-associate...

211

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01516
(show subtarget assignments)

1

crystallized

No

VC0576

15640598

sspA

stringent starvation protein A

211

Conserved Gene / Pathway

Phase 2: March 2008

1YY7

73.9%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP01990
(show subtarget assignments)

0

work_stopped

No

Cj1435c

15792753

hypothetical protein Cj1435c [Campylobac...

211

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

3FVV

26.1%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01447
(show subtarget assignments)

1

in_crystallization_trials

No

VC2181

15642180

lolB

outer membrane lipoprotein LolB

211

Conserved Gene / Pathway

Phase 2: March 2008

1IWM

30.3%

Vibrio cholerae

Cell envelope

Other

IDP02365
(show subtarget assignments)

1

purified

No

FTT0403

56707552

def1

peptide deformylase [Francisella tularen...

211

Conserved; Drug target functions

Phase 3: June 2008

3M6O

28.4%

Francisella tularensis

Protein fate

Protein modification and repair

IDP91355
(show subtarget assignments)

8

soluble

No

VV1_3022

27366292

cob(I)yrinic acid a,c-diamide adenosyltr...

211

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1G5R

59.2%

Vibrio vulnificus

IDP04087
(show subtarget assignments)

1

cloned

No

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP90994
(show subtarget assignments)

8

purified

No

y1355

22125254

hypothetical protein y1355 [Yersinia pes...

211

other biological interest / -

Community Requests

Yersinia pestis

IDP05261
(show subtarget assignments)

1

cloned

No

CD2772

126700388

tuaG

putative teichuronic acid biosynthesis g...

212

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3BCV

23.6%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00455
(show subtarget assignments)

1

purified

No

YPO3080

16123257

tesA

multifunctional acyl-CoA thioesterase I ...

212

Conserved Gene / Pathway

Phase 2: March 2008

1IVN

60.4%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00836
(show subtarget assignments)

1

in_pdb
3GIU

No

SACOL2714

57285268

pcp

pyrrolidone-carboxylate peptidase

212

Drug Target Function

Phase 2: March 2008

3GIU

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides