Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02154 (show subtarget assignments)	1	expressed	No	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01407 (show subtarget assignments)	1	cloned	No	VC0947	15640963		D-alanyl-D-alanine carboxypeptidase	391	Drug Target Function	Phase 2: March 2008	1NZO	52.2%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01394 (show subtarget assignments)	1	soluble	No	VC0700	15640719		soluble lytic murein transglycosylase	648	Drug Target Function	Phase 2: March 2008	1QSA	33.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00347 (show subtarget assignments)	1	in_pdb 3HFR 3ISV 3IST	Yes	lmo1237	16803277	racE	hypothetical protein lmo1237	266	Drug Target Function	Phase 2: March 2008	3HFR	100%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02286 (show subtarget assignments)	1	cloned	No	FTT1029	56708118	dacD	D-alanyl-D-alanine carboxypeptidase (pen...	444	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IT9	31.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455 (show subtarget assignments)	1	purified	No	VC2405	15642402		UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	453	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	52.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02037 (show subtarget assignments)	1	cloned	No	CBU_0135	29540755	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	358	Conserved; Drug target functions	Phase 3: June 2008	1F0K	46.6%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00345 (show subtarget assignments)	1	cloned	No	lmo0441	16802485		hypothetical protein lmo0441	678	Drug Target Function	Phase 2: March 2008	1MWR	35.3%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01375 (show subtarget assignments)	1	in_crystallization_trials	No	VC0372	15640399	alr	alanine racemase	375	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	57.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01374 (show subtarget assignments)	1	purified	No	VC0344	15640371		N-acetylmuramoyl-L-alanine amidase	581	Conserved Gene / Pathway	Phase 2: March 2008	3NE8	13.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00344 (show subtarget assignments)	1	cloned	No	lmo2039	16804078	pbpB	hypothetical protein lmo2039	751	Drug Target Function	Phase 2: March 2008	1RP5	34.1%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01372 (show subtarget assignments)	1	in_pdb 3I99	No	VC0318	15640345	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	357	Drug Target Function	Phase 2: March 2008	3I99	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00694 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2151	57286365	glmM	phosphoglucosamine mutase GlmM	451	Drug Target Function	Phase 2: March 2008	3PDK	67.4%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00018 (show subtarget assignments)	0	work_stopped	No	BA_4717	30259210	racE-2	glutamate racemase	269	Drug Target Homolog	Phase 1: October 2007	2GZM	99.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01362 (show subtarget assignments)	1	purified	No	VC0158	15640188		glutamate racemase	265	Drug Target Function	Phase 2: March 2008	2JFN	49.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00690 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2092	57284959	murAA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	421	Drug Target Function	Phase 2: March 2008	3SG1	64.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00689 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2073	57284941	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	2AM1	33.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00688 (show subtarget assignments)	1	in_pdb 3OO2	Yes	SACOL2060	57284928	alr	alanine racemase	382	Conserved Gene / Pathway	Phase 2: March 2008	3OO2	100%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00335 (show subtarget assignments)	1	in_pdb 3OUT	No	FTT1197c	56708260	murI	glutamate racemase	265	Drug Target Function	Phase 2: March 2008	3OUT	100%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00674 (show subtarget assignments)	1	crystallized	No	SACOL1453	57286104	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	25.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02666 (show subtarget assignments)	1	cloned	No	GBAA1490	47777937		D-alanyl-D-alanine carboxypeptidase fami...	374	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3MFD	44.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00668 (show subtarget assignments)	1	crystallized	No	SACOL1196	57284481	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	449	Conserved Gene / Pathway	Phase 2: March 2008	3LK7	46.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02576 (show subtarget assignments)	1	purified	No	GBAA0246	47525503	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	458	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2AM1	37.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01258 (show subtarget assignments)	1	soluble	No	BA_2238	30256883	pbpC	penicillin-binding protein 3	661	Drug Target Function	Phase 2: March 2008	1MWR	34.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00658 (show subtarget assignments)	0	work_stopped	No	SACOL0801	57285762	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	307	Drug Target Function	Phase 2: March 2008	1HSK	99.3%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01253 (show subtarget assignments)	1	cloned	No	BA_2575	30257197		penicillin-binding protein, putative	481	Drug Target Function	Phase 2: March 2008	2QMI	20%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01252 (show subtarget assignments)	1	cloned	No	BA_5623	30260075		penicillin-binding protein	683	Drug Target Function	Phase 2: March 2008	3UDF	28.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251 (show subtarget assignments)	1	cloned	No	BA_4606	30259106		penicillin-binding protein	584	Drug Target Function	Phase 2: March 2008	3OC2	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01743 (show subtarget assignments)	1	purified	No	CBU_1350	29541915	glmM	phosphoglucosamine mutase [Coxiella burn...	446	Conserved; Drug target functions	Phase 3: June 2008	3PDK	44.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250 (show subtarget assignments)	1	cloned	No	BA_4497	30259003		penicillin-binding protein	706	Drug Target Function	Phase 2: March 2008	2WAF	33%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01248 (show subtarget assignments)	1	soluble	No	BA_3554	30258085		penicillin-binding protein, putative	377	Drug Target Function	Phase 2: March 2008	3TG9	23.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01247 (show subtarget assignments)	1	soluble	No	BA_3214	30257780		penicillin-binding protein, putative	691	Drug Target Function	Phase 2: March 2008	2QMI	14.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243 (show subtarget assignments)	1	cloned	No	BA_2345	30256982		penicillin-binding protein 1A	820	Drug Target Function	Phase 2: March 2008	2OLU	29.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01242 (show subtarget assignments)	1	soluble	No	BA_1572	30255873		penicillin-binding protein	897	Drug Target Function	Phase 2: March 2008	2OLU	27.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01241 (show subtarget assignments)	1	expressed	No	BA_1474	30255405		penicillin-binding protein	673	Drug Target Function	Phase 2: March 2008	2JCH	28.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01240 (show subtarget assignments)	1	cloned	No	BA_1069	30254800	pbpF	penicillin-binding protein 1	705	Drug Target Function	Phase 2: March 2008	2OLU	27.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02024 (show subtarget assignments)	1	expressed	No	CBU_0131	29540751	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	442	Conserved; Drug target functions	Phase 3: June 2008	1E0D	43%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00320 (show subtarget assignments)	1	expressed	No	CBU_0550	29653890	pbpA	penicillin-binding protein 2	612	Drug Target Function	Phase 2: March 2008	1MWR	25.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01231 (show subtarget assignments)	1	purified	No	BA_4684	30259179	mreB	rod shape-determining protein MreB	339	Drug Target Function	Phase 2: March 2008	1JCE	52.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01223 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4051	60390084		UDP-N-acetylmuramoylalanine--D-glutamate...	450	Conserved Gene / Pathway	Phase 2: March 2008	3LK7	52.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00317 (show subtarget assignments)	1	cloned	No	CBU_1887	29655172	ponA	penicillin-binding protein 1A	793	Drug Target Function	Phase 2: March 2008	3UDF	40.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222 (show subtarget assignments)	1	purified	No	BA_4049	33301352		UDP-N-acetylglucosamine--N-acetylmuramyl...	364	Drug Target Function	Phase 2: March 2008	1F0K	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02026 (show subtarget assignments)	1	crystallized	No	CBU_0123	29540743	murE	UDP-N-acetylmuramoylalanyl-D-glutamate-2...	489	Conserved; Drug target functions	Phase 3: June 2008	1E8C	41.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01215 (show subtarget assignments)	1	expressed	No	BA_3506	30258044		penicillin-binding protein, putative	345	Drug Target Function	Phase 2: March 2008	2QMI	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00314 (show subtarget assignments)	1	expressed	No	CBU_0751	29654085	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Function	Phase 2: March 2008	1EJC	57.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01209 (show subtarget assignments)	1	soluble	No	BA_2650	30257267		penicillin-binding protein	340	Drug Target Function	Phase 2: March 2008	3TG9	53.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01207 (show subtarget assignments)	1	in_pdb 3R5X 3R23	Yes	BA_2610	39930865		D-alanine--D-alanine ligase (D-alanylala...	304	Conserved Gene / Pathway	Phase 2: March 2008	3R23	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01202 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2079	30256728	dal-2	alanine racemase	391	Drug Target Function	Phase 2: March 2008	3E5P	41.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00016 (show subtarget assignments)	1	crystallized	No	BA_4053	46576983		UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	491	Drug Target Homolog	Phase 1: October 2007	2WTZ	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00309 (show subtarget assignments)	1	expressed	No	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01188 (show subtarget assignments)	1	expressed	No	BA_0502	30254030		penicillin-binding protein, putative	412	Drug Target Function	Phase 2: March 2008	2QMI	21.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02223 (show subtarget assignments)	1	expressed	No	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02225 (show subtarget assignments)	1	cloned	No	CBU_1338	29541903		D-alanine--D-alanine ligase [Coxiella bu...	372	Conserved; Drug target functions	Phase 3: June 2008	3TQT	100%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00306 (show subtarget assignments)	1	expressed	No	CBU_0137	29653495	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	316	Drug Target Function	Phase 2: March 2008	3TX1	34.8%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02693 (show subtarget assignments)	1	crystallized	No	FTT0185	56707350	ddlB	D-alanine--D-alanine ligase B [Francisel...	296	Conserved; Drug target functions	Phase 3: June 2008	3V4Z	43.9%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00305 (show subtarget assignments)	1	cloned	No	CBU_0118	29653476	pbpB	penicillin-binding protein 3	548	Drug Target Function	Phase 2: March 2008	3OC2	45.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01733 (show subtarget assignments)	1	cloned	No	FTT0811c	56707922	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	371	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1F0K	39.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00607 (show subtarget assignments)	1	soluble	No	SACOL2116	57286332	murAB	UDP-N-acetylglucosamine 1-carboxyvinyltr...	419	Drug Target Function	Phase 2: March 2008	3SG1	47%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02791 (show subtarget assignments)	1	cloned	No	lmo1892	16803931	pbpA	hypothetical protein lmo1892 [Listeria m...	827	Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...	Phase 3: June 2008	2OLU	30.8%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01152 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5520	30259980	mbl	mbl protein	333	Conserved Gene / Pathway	Phase 2: March 2008	1JCE	50.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597 (show subtarget assignments)	1	purified	No	YPO3909	16124041	murI	glutamate racemase	287	Conserved Gene / Pathway	Phase 2: March 2008	2JFN	71.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00596 (show subtarget assignments)	1	purified	No	YPO0555	16120883	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	78.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01726 (show subtarget assignments)	1	cloned	No	GBAA5252	47530558		D-alanyl-D-alanine carboxypeptidase fami...	279	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	29.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00595 (show subtarget assignments)	1	crystallized	No	YPO3760	16123897	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	345	Drug Target Function	Phase 2: March 2008	1MBB	60.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00594 (show subtarget assignments)	0	work_stopped	No	YPO3569	16123713	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	420	Conserved Gene / Pathway	Phase 2: March 2008	1NAW	91.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00592 (show subtarget assignments)	1	cloned	No	YPO3393	16123542	mrcB	penicillin-binding protein 1b	824	Virulence Associated Factor	Phase 2: March 2008	3VMA	66.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00591 (show subtarget assignments)	1	cloned	No	YPO0145	161486893	mrcA	penicillin-binding protein	859	Drug Target Function	Phase 2: March 2008	3UDF	36.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00590 (show subtarget assignments)	1	cloned	No	YPO1078	16121379	mltD	predicted membrane-bound lytic murein tr...	475	Drug Target Function	Phase 2: March 2008	1E0G	7.8%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02126 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1221	56708283		hypothetical protein FTT1221 [Francisell...	88	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelopeRegulatory functions,Unknown function	Biosynthesis and degradation of murein sacculus and peptidoglycanOther,General

IDP02539 (show subtarget assignments)	1	cloned	No	YPO3200	16123361	malZ	maltodextrin glucosidase [Yersinia pesti...	609	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EA9	33.5%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00553 (show subtarget assignments)	1	expressed	No	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01934 (show subtarget assignments)	1	soluble	No	GBAA0385	47525656		chitinase B [Bacillus anthracis str. 'Am...	674	Drug target motif; Drug target functions	Phase 3: June 2008	1ITX	37.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00110 (show subtarget assignments)	1	purified	No	NT01SF4145	30043548	glgC	glucose-1-phosphate adenylyltransferase ...	431	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3BRK	55.2%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01824 (show subtarget assignments)	1	cloned	No	STM3197	16766497	glgS	glycogen synthesis protein GlgS [Salmone...	69	Conserved; Drug target functions	Phase 3: June 2008	1RRZ	73.9%	Salmonella enterica	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01806 (show subtarget assignments)	1	soluble	No	lmo1883	16803922		hypothetical protein lmo1883 [Listeria m...	352	Presence of Protease Motifs; Predicted involvement in glycosyl group metabolism	Phase 3: June 2008	3IAN	53.1%	Listeria monocytogenes	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00498 (show subtarget assignments)	1	cloned	No	YPO0166	16120509		putative glycosyl hydrolase	437	Drug Target Function	Phase 2: March 2008	1S6Y	52.6%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00096 (show subtarget assignments)	1	in_crystallization_trials	No	NTL02SF1070	30040886	ycfO	hypothetical protein S1191	341	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1TR9	55.7%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04508 (show subtarget assignments)	1	cloned	No	CPF_0372	110799482		polysaccharide deacetylase family protei...	306	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NY1	17.6%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00463 (show subtarget assignments)	1	purified	No	YPO1615	16121883		beta-hexosaminidase	343	Drug Target Function	Phase 2: March 2008	2OXN	55.1%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04235 (show subtarget assignments)	1	cloned	No	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02717 (show subtarget assignments)	1	cloned	No	GBAA3854	47529142	chi36	extracellular exochitinase Chi36 [Bacill...	360	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3N11	88.6%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04454 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1254	218928409	bglA	6-phospho-beta-glucosidase [Yersinia pes...	478	drug target; putative drug target function;	Phase 4: April 2009	2XHY	77.8%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00686 (show subtarget assignments)	1	purified	No	SACOL2029	57284899	cscA	sucrose-6-phosphate hydrolase	494	Drug Target Function	Phase 2: March 2008	1UYP	29.8%	Staphylococcus aureus	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01646 (show subtarget assignments)	1	soluble	No	GBAA5119	47530423	glgP	glycogen phosphorylase [Bacillus anthrac...	802	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AXR	46.5%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02575 (show subtarget assignments)	1	cloned	No	GBAA5123	47778366	glgB	glycogen branching enzyme [Bacillus anth...	645	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3K1D	43.4%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01138 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4230	30258733		alpha-amylase	586	Drug Target Function	Phase 2: March 2008	1J0H	61%	Bacillus anthracis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP01116 (show subtarget assignments)	1	expressed	No	BA_1693	30255984		glycosyl transferase, group 2 family pro...	150	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02623 (show subtarget assignments)	1	cloned	No	Cj1430c	15792748		putative nucleotide-sugar epimerase/dehy...	181	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1DZR	30.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01110 (show subtarget assignments)	1	in_pdb 3RYK	Yes	BA_1229	30255178	rfbC	dTDP-4-dehydrorhamnose 3,5-epimerase	181	Conserved Gene / Pathway	Phase 2: March 2008	3RYK	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00124 (show subtarget assignments)	0	work_stopped	No	NT01ST0382	16763693	ghmA	phosphoheptose isomerase	192		Phase 1: October 2007	2I22	97.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602 (show subtarget assignments)	1	cloned	No	Cj1148	15792472	waaF	ADP-heptose--LPS heptosyltransferase II ...	319	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	1PSW	24.7%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00123 (show subtarget assignments)	1	expressed	No	NT01ST4633	16766997	rfaC	ADP-heptose:LPS heptosyl transferase I	317	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GT1	83.3%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02824 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA5152	47530456	gtaB	UTP-glucose-1-phosphate uridylyltransfer...	295	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2UX8	51.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01068 (show subtarget assignments)	0	work_stopped	No	STM3920	16767195	wecB	UDP-N-acetyl glucosamine-2-epimerase	376	Drug Target Function	Phase 2: March 2008	1F6D	85.9%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00121 (show subtarget assignments)	1	in_pdb 3DQQ	No	NT01ST3629	16766223	ygbK	putative tRNA synthase	420	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DQQ	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02154
(show subtarget assignments)

1

expressed

No

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01407
(show subtarget assignments)

1

cloned

No

VC0947

15640963

D-alanyl-D-alanine carboxypeptidase

391

Drug Target Function

Phase 2: March 2008

1NZO

52.2%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01394
(show subtarget assignments)

1

soluble

No

VC0700

15640719

soluble lytic murein transglycosylase

648

Drug Target Function

Phase 2: March 2008

1QSA

33.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00347
(show subtarget assignments)

1

in_pdb
3HFR
3ISV
3IST

Yes

lmo1237

16803277

racE

hypothetical protein lmo1237

266

Drug Target Function

Phase 2: March 2008

3HFR

100%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02286
(show subtarget assignments)

1

cloned

No

FTT1029

56708118

dacD

D-alanyl-D-alanine carboxypeptidase (pen...

444

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IT9

31.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455
(show subtarget assignments)

1

purified

No

VC2405

15642402

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

453

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

52.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02037
(show subtarget assignments)

1

cloned

No

CBU_0135

29540755

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

358

Conserved; Drug target functions

Phase 3: June 2008

1F0K

46.6%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00345
(show subtarget assignments)

1

cloned

No

lmo0441

16802485

hypothetical protein lmo0441

678

Drug Target Function

Phase 2: March 2008

1MWR

35.3%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01375
(show subtarget assignments)

1

in_crystallization_trials

No

VC0372

15640399

alr

alanine racemase

375

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

57.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01374
(show subtarget assignments)

1

purified

No

VC0344

15640371

N-acetylmuramoyl-L-alanine amidase

581

Conserved Gene / Pathway

Phase 2: March 2008

3NE8

13.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00344
(show subtarget assignments)

1

cloned

No

lmo2039

16804078

pbpB

hypothetical protein lmo2039

751

Drug Target Function

Phase 2: March 2008

1RP5

34.1%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01372
(show subtarget assignments)

1

in_pdb
3I99

No

VC0318

15640345

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

357

Drug Target Function

Phase 2: March 2008

3I99

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00694
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2151

57286365

glmM

phosphoglucosamine mutase GlmM

451

Drug Target Function

Phase 2: March 2008

3PDK

67.4%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00018
(show subtarget assignments)

0

work_stopped

No

BA_4717

30259210

racE-2

glutamate racemase

269

Drug Target Homolog

Phase 1: October 2007

2GZM

99.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01362
(show subtarget assignments)

1

purified

No

VC0158

15640188

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

2JFN

49.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00690
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2092

57284959

murAA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

421

Drug Target Function

Phase 2: March 2008

3SG1

64.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00689
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2073

57284941

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

2AM1

33.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00688
(show subtarget assignments)

1

in_pdb
3OO2

Yes

SACOL2060

57284928

alr

alanine racemase

382

Conserved Gene / Pathway

Phase 2: March 2008

3OO2

100%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00335
(show subtarget assignments)

1

in_pdb
3OUT

No

FTT1197c

56708260

murI

glutamate racemase

265

Drug Target Function

Phase 2: March 2008

3OUT

100%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00674
(show subtarget assignments)

1

crystallized

No

SACOL1453

57286104

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

25.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02666
(show subtarget assignments)

1

cloned

No

GBAA1490

47777937

D-alanyl-D-alanine carboxypeptidase fami...

374

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3MFD

44.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00668
(show subtarget assignments)

1

crystallized

No

SACOL1196

57284481

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

449

Conserved Gene / Pathway

Phase 2: March 2008

3LK7

46.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02576
(show subtarget assignments)

1

purified

No

GBAA0246

47525503

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

458

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2AM1

37.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01258
(show subtarget assignments)

1

soluble

No

BA_2238

30256883

pbpC

penicillin-binding protein 3

661

Drug Target Function

Phase 2: March 2008

1MWR

34.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00658
(show subtarget assignments)

0

work_stopped

No

SACOL0801

57285762

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

307

Drug Target Function

Phase 2: March 2008

1HSK

99.3%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01253
(show subtarget assignments)

1

cloned

No

BA_2575

30257197

penicillin-binding protein, putative

481

Drug Target Function

Phase 2: March 2008

2QMI

20%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01252
(show subtarget assignments)

1

cloned

No

BA_5623

30260075

penicillin-binding protein

683

Drug Target Function

Phase 2: March 2008

3UDF

28.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251
(show subtarget assignments)

1

cloned

No

BA_4606

30259106

penicillin-binding protein

584

Drug Target Function

Phase 2: March 2008

3OC2

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01743
(show subtarget assignments)

1

purified

No

CBU_1350

29541915

glmM

phosphoglucosamine mutase [Coxiella burn...

446

Conserved; Drug target functions

Phase 3: June 2008

3PDK

44.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250
(show subtarget assignments)

1

cloned

No

BA_4497

30259003

penicillin-binding protein

706

Drug Target Function

Phase 2: March 2008

2WAF

33%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01248
(show subtarget assignments)

1

soluble

No

BA_3554

30258085

penicillin-binding protein, putative

377

Drug Target Function

Phase 2: March 2008

3TG9

23.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01247
(show subtarget assignments)

1

soluble

No

BA_3214

30257780

penicillin-binding protein, putative

691

Drug Target Function

Phase 2: March 2008

2QMI

14.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243
(show subtarget assignments)

1

cloned

No

BA_2345

30256982

penicillin-binding protein 1A

820

Drug Target Function

Phase 2: March 2008

2OLU

29.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01242
(show subtarget assignments)

1

soluble

No

BA_1572

30255873

penicillin-binding protein

897

Drug Target Function

Phase 2: March 2008

2OLU

27.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01241
(show subtarget assignments)

1

expressed

No

BA_1474

30255405

penicillin-binding protein

673

Drug Target Function

Phase 2: March 2008

2JCH

28.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01240
(show subtarget assignments)

1

cloned

No

BA_1069

30254800

pbpF

penicillin-binding protein 1

705

Drug Target Function

Phase 2: March 2008

2OLU

27.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02024
(show subtarget assignments)

1

expressed

No

CBU_0131

29540751

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

442

Conserved; Drug target functions

Phase 3: June 2008

1E0D

43%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00320
(show subtarget assignments)

1

expressed

No

CBU_0550

29653890

pbpA

penicillin-binding protein 2

612

Drug Target Function

Phase 2: March 2008

1MWR

25.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01231
(show subtarget assignments)

1

purified

No

BA_4684

30259179

mreB

rod shape-determining protein MreB

339

Drug Target Function

Phase 2: March 2008

1JCE

52.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01223
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4051

60390084

UDP-N-acetylmuramoylalanine--D-glutamate...

450

Conserved Gene / Pathway

Phase 2: March 2008

3LK7

52.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00317
(show subtarget assignments)

1

cloned

No

CBU_1887

29655172

ponA

penicillin-binding protein 1A

793

Drug Target Function

Phase 2: March 2008

3UDF

40.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222
(show subtarget assignments)

1

purified

No

BA_4049

33301352

UDP-N-acetylglucosamine--N-acetylmuramyl...

364

Drug Target Function

Phase 2: March 2008

1F0K

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02026
(show subtarget assignments)

1

crystallized

No

CBU_0123

29540743

murE

UDP-N-acetylmuramoylalanyl-D-glutamate-2...

489

Conserved; Drug target functions

Phase 3: June 2008

1E8C

41.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01215
(show subtarget assignments)

1

expressed

No

BA_3506

30258044

penicillin-binding protein, putative

345

Drug Target Function

Phase 2: March 2008

2QMI

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00314
(show subtarget assignments)

1

expressed

No

CBU_0751

29654085

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Function

Phase 2: March 2008

1EJC

57.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01209
(show subtarget assignments)

1

soluble

No

BA_2650

30257267

penicillin-binding protein

340

Drug Target Function

Phase 2: March 2008

3TG9

53.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01207
(show subtarget assignments)

1

in_pdb
3R5X
3R23

Yes

BA_2610

39930865

D-alanine--D-alanine ligase (D-alanylala...

304

Conserved Gene / Pathway

Phase 2: March 2008

3R23

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01202
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2079

30256728

dal-2

alanine racemase

391

Drug Target Function

Phase 2: March 2008

3E5P

41.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00016
(show subtarget assignments)

1

crystallized

No

BA_4053

46576983

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

491

Drug Target Homolog

Phase 1: October 2007

2WTZ

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00309
(show subtarget assignments)

1

expressed

No

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01188
(show subtarget assignments)

1

expressed

No

BA_0502

30254030

penicillin-binding protein, putative

412

Drug Target Function

Phase 2: March 2008

2QMI

21.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02223
(show subtarget assignments)

1

expressed

No

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02225
(show subtarget assignments)

1

cloned

No

CBU_1338

29541903

D-alanine--D-alanine ligase [Coxiella bu...

372

Conserved; Drug target functions

Phase 3: June 2008

3TQT

100%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00306
(show subtarget assignments)

1

expressed

No

CBU_0137

29653495

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

316

Drug Target Function

Phase 2: March 2008

3TX1

34.8%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02693
(show subtarget assignments)

1

crystallized

No

FTT0185

56707350

ddlB

D-alanine--D-alanine ligase B [Francisel...

296

Conserved; Drug target functions

Phase 3: June 2008

3V4Z

43.9%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00305
(show subtarget assignments)

1

cloned

No

CBU_0118

29653476

pbpB

penicillin-binding protein 3

548

Drug Target Function

Phase 2: March 2008

3OC2

45.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01733
(show subtarget assignments)

1

cloned

No

FTT0811c

56707922

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

371

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1F0K

39.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00607
(show subtarget assignments)

1

soluble

No

SACOL2116

57286332

murAB

UDP-N-acetylglucosamine 1-carboxyvinyltr...

419

Drug Target Function

Phase 2: March 2008

3SG1

47%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02791
(show subtarget assignments)

1

cloned

No

lmo1892

16803931

pbpA

hypothetical protein lmo1892 [Listeria m...

827

Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...

Phase 3: June 2008

2OLU

30.8%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01152
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5520

30259980

mbl

mbl protein

333

Conserved Gene / Pathway

Phase 2: March 2008

1JCE

50.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597
(show subtarget assignments)

1

purified

No

YPO3909

16124041

murI

glutamate racemase

287

Conserved Gene / Pathway

Phase 2: March 2008

2JFN

71.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00596
(show subtarget assignments)

1

purified

No

YPO0555

16120883

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

78.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01726
(show subtarget assignments)

1

cloned

No

GBAA5252

47530558

D-alanyl-D-alanine carboxypeptidase fami...

279

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

29.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00595
(show subtarget assignments)

1

crystallized

No

YPO3760

16123897

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

345

Drug Target Function

Phase 2: March 2008

1MBB

60.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00594
(show subtarget assignments)

0

work_stopped

No

YPO3569

16123713

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

420

Conserved Gene / Pathway

Phase 2: March 2008

1NAW

91.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00592
(show subtarget assignments)

1

cloned

No

YPO3393

16123542

mrcB

penicillin-binding protein 1b

824

Virulence Associated Factor

Phase 2: March 2008

3VMA

66.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00591
(show subtarget assignments)

1

cloned

No

YPO0145

161486893

mrcA

penicillin-binding protein

859

Drug Target Function

Phase 2: March 2008

3UDF

36.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00590
(show subtarget assignments)

1

cloned

No

YPO1078

16121379

mltD

predicted membrane-bound lytic murein tr...

475

Drug Target Function

Phase 2: March 2008

1E0G

7.8%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02126
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1221

56708283

hypothetical protein FTT1221 [Francisell...

88

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelopeRegulatory functions,Unknown function

Biosynthesis and degradation of murein sacculus and peptidoglycanOther,General

IDP02539
(show subtarget assignments)

1

cloned

No

YPO3200

16123361

malZ

maltodextrin glucosidase [Yersinia pesti...

609

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EA9

33.5%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00553
(show subtarget assignments)

1

expressed

No

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01934
(show subtarget assignments)

1

soluble

No

GBAA0385

47525656

chitinase B [Bacillus anthracis str. 'Am...

674

Drug target motif; Drug target functions

Phase 3: June 2008

1ITX

37.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00110
(show subtarget assignments)

1

purified

No

NT01SF4145

30043548

glgC

glucose-1-phosphate adenylyltransferase ...

431

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3BRK

55.2%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01824
(show subtarget assignments)

1

cloned

No

STM3197

16766497

glgS

glycogen synthesis protein GlgS [Salmone...

69

Conserved; Drug target functions

Phase 3: June 2008

1RRZ

73.9%

Salmonella enterica

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01806
(show subtarget assignments)

1

soluble

No

lmo1883

16803922

hypothetical protein lmo1883 [Listeria m...

352

Presence of Protease Motifs; Predicted involvement in glycosyl group metabolism

Phase 3: June 2008

3IAN

53.1%

Listeria monocytogenes

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00498
(show subtarget assignments)

1

cloned

No

YPO0166

16120509

putative glycosyl hydrolase

437

Drug Target Function

Phase 2: March 2008

1S6Y

52.6%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00096
(show subtarget assignments)

1

in_crystallization_trials

No

NTL02SF1070

30040886

ycfO

hypothetical protein S1191

341

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1TR9

55.7%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04508
(show subtarget assignments)

1

cloned

No

CPF_0372

110799482

polysaccharide deacetylase family protei...

306

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NY1

17.6%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00463
(show subtarget assignments)

1

purified

No

YPO1615

16121883

beta-hexosaminidase

343

Drug Target Function

Phase 2: March 2008

2OXN

55.1%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04235
(show subtarget assignments)

1

cloned

No

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02717
(show subtarget assignments)

1

cloned

No

GBAA3854

47529142

chi36

extracellular exochitinase Chi36 [Bacill...

360

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3N11

88.6%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04454
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1254

218928409

bglA

6-phospho-beta-glucosidase [Yersinia pes...

478

drug target; putative drug target function;

Phase 4: April 2009

2XHY

77.8%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00686
(show subtarget assignments)

1

purified

No

SACOL2029

57284899

cscA

sucrose-6-phosphate hydrolase

494

Drug Target Function

Phase 2: March 2008

1UYP

29.8%

Staphylococcus aureus

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01646
(show subtarget assignments)

1

soluble

No

GBAA5119

47530423

glgP

glycogen phosphorylase [Bacillus anthrac...

802

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AXR

46.5%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02575
(show subtarget assignments)

1

cloned

No

GBAA5123

47778366

glgB

glycogen branching enzyme [Bacillus anth...

645

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3K1D

43.4%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01138
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4230

30258733

alpha-amylase

586

Drug Target Function

Phase 2: March 2008

1J0H

61%

Bacillus anthracis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP01116
(show subtarget assignments)

1

expressed

No

BA_1693

30255984

glycosyl transferase, group 2 family pro...

150

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02623
(show subtarget assignments)

1

cloned

No

Cj1430c

15792748

putative nucleotide-sugar epimerase/dehy...

181

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1DZR

30.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01110
(show subtarget assignments)

1

in_pdb
3RYK

Yes

BA_1229

30255178

rfbC

dTDP-4-dehydrorhamnose 3,5-epimerase

181

Conserved Gene / Pathway

Phase 2: March 2008

3RYK

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00124
(show subtarget assignments)

0

work_stopped

No

NT01ST0382

16763693

ghmA

phosphoheptose isomerase

192

Phase 1: October 2007

2I22

97.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02602
(show subtarget assignments)

1

cloned

No

Cj1148

15792472

waaF

ADP-heptose--LPS heptosyltransferase II ...

319

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

1PSW

24.7%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00123
(show subtarget assignments)

1

expressed

No

NT01ST4633

16766997

rfaC

ADP-heptose:LPS heptosyl transferase I

317

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GT1

83.3%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02824
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA5152

47530456

gtaB

UTP-glucose-1-phosphate uridylyltransfer...

295

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2UX8

51.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01068
(show subtarget assignments)

0

work_stopped

No

STM3920

16767195

wecB

UDP-N-acetyl glucosamine-2-epimerase

376

Drug Target Function

Phase 2: March 2008

1F6D

85.9%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00121
(show subtarget assignments)

1

in_pdb
3DQQ

No

NT01ST3629

16766223

ygbK

putative tRNA synthase

420

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DQQ

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

Targets