Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04707 (show subtarget assignments)	1	cloned	No	BAS0113	49183147		50S ribosomal protein L2 [Bacillus anthr...	276	Proposed to be essential proteins	Phase 4: April 2009	1VSA	65%	Bacillus anthracis

IDP05393 (show subtarget assignments)	1	expressed	No	BA_3225	30257788		hypothetical protein BA_3225 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05638 (show subtarget assignments)	1	cloned	No	CD2546	126700163		endoglucanase (cellulase) [Clostridium d...	340	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3AMC	39.7%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05349 (show subtarget assignments)	1	cloned	No	CD2487	126700104		PTS system, IIB component [Clostridium d...	105	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KYR	67.6%	Clostridium difficile	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP05247 (show subtarget assignments)	1	cloned	No	lmo2636	16804674	-	hypothetical protein lmo2636 [Listeria m...	360	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VRM	29.4%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04211 (show subtarget assignments)	1	expressed	No	STM0408_1_323	16763788	secF	preprotein translocase subunit SecF [Sal...	323	Salmonella essential protein	Phase 4: April 2009	3AQP	35.3%	Salmonella enterica

IDP05345 (show subtarget assignments)	1	soluble	No	Z3383	12516442	pbpG	penicillin-binding protein 7 [Escherichi...	313	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1XP4	25.9%	Escherichia coli	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05332 (show subtarget assignments)	1	soluble	No	Z4866	12518154		putative beta-ketoacyl-ACP synthase [Esc...	409	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	4EWG	59.7%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP05331 (show subtarget assignments)	1	soluble	No	SACOL0009	57651117	serS	seryl-tRNA synthetase [Staphylococcus au...	428	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2DQ3	51.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05248 (show subtarget assignments)	1	expressed	No	lmo2691	16804728	-	autolysin [Listeria monocytogenes EGD-e]...	590	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	16.1%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05515 (show subtarget assignments)	1	cloned	No	CD1687	126699293		putative lipoprotein [Clostridium diffic...	278	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP04731 (show subtarget assignments)	1	crystallized	No	BAS3675	49186674		ribosome recycling factor [Bacillus anth...	185	Proposed to be essential proteins	Phase 4: April 2009	1IS1	50.8%	Bacillus anthracis

IDP05338 (show subtarget assignments)	1	cloned	No	lmo1598	16803638	tyrS	tyrosyl-tRNA synthetase [Listeria monocy...	419	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2TS1	62.8%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05403 (show subtarget assignments)	1	soluble	No	BA_4464	30258958	comGC	comG operon protein 3 [Bacillus anthraci...	99	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: DNA transformation

IDP04728 (show subtarget assignments)	1	selected	No	BAS0102	49183136		DNA-directed RNA polymerase subunit beta...	1177	Proposed to be essential proteins	Phase 4: April 2009	1HQM	49.2%	Bacillus anthracis

IDP91004 (show subtarget assignments)	8	soluble	No	y1935	22125827		cysteine desulfurase activator complex s...	503	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	4DN7	18.7%	Yersinia pestis

IDP05253 (show subtarget assignments)	1	cloned	No	CD0259	126697831		putative flagellar protein [Clostridium ...	107	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05250 (show subtarget assignments)	1	soluble	No	lmo2446	16804484	-	hypothetical protein lmo2446 [Listeria m...	1091	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2X2H	19%	Listeria monocytogenes	Central intermediary metabolism: Other

IDP05009 (show subtarget assignments)	1	soluble	No	BA_4237	30258740		putative lipoprotein [Bacillus anthracis...	253	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP04730 (show subtarget assignments)	1	cloned	No	BAS4284	49187280		alanyl-tRNA synthetase [Bacillus anthrac...	880	Proposed to be essential proteins	Phase 4: April 2009	1RIQ	26.3%	Bacillus anthracis

IDP05336 (show subtarget assignments)	1	soluble	No	Cj0799c	6968240	ruvA	hypothetical protein Cj0794 [Campylobact...	183	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	32.5%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP05335 (show subtarget assignments)	1	expressed	No	BAS2222	49185231	-	threonyl-tRNA synthetase [Bacillus anthr...	639	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NYQ	50.5%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP05517 (show subtarget assignments)	1	soluble	No	CD1699	126699305	ribB	riboflavin synthase subunit alpha [Clost...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KZL	38.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05334 (show subtarget assignments)	1	soluble	No	SACOL1808	57652056	leuS	leucyl-tRNA synthetase [Staphylococcus a...	805	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H3N	46.4%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP91001 (show subtarget assignments)	8	soluble	No	y1897	22125790	yfeA	periplasmic-binding protein [Yersinia pe...	323	virulence/pathogenesis / periplasmic iron-binding protein	Community Requests	1XVL	52.9%	Yersinia pestis

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP05252 (show subtarget assignments)	1	soluble	No	lmo2854	16804891	-	hypothetical protein lmo2854 [Listeria m...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Cell envelope: Other

IDP05681 (show subtarget assignments)	1	cloned	No	lmo1277	16803317	codV	hypothetical protein lmo1277 [Listeria m...	300	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1A0P	35%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Prophage functions

IDP05392 (show subtarget assignments)	1	cloned	No	BA_3222	30257786		hypothetical protein BA_3222 [Bacillus a...	56	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP04013 (show subtarget assignments)	1	cloned	No	STM2913_1_498	16766219		putative permease [Salmonella typhimuriu...	498	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP05516 (show subtarget assignments)	1	soluble	No	CD1697	126699303	ribH	riboflavin synthase beta chain (6,7-dime...	158	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RVV	66.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05337 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1282	57651833	proS	prolyl-tRNA synthetase [Staphylococcus a...	567	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2J3L	55.7%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05001 (show subtarget assignments)	1	purified	No	BA_1090	30254820		putative lipoprotein [Bacillus anthracis...	142	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP04732 (show subtarget assignments)	1	cloned	No	BAS5341	49188325		50S ribosomal protein L34 [Bacillus anth...	44	Proposed to be essential proteins	Phase 4: April 2009	1NKW	65.9%	Bacillus anthracis

IDP05003 (show subtarget assignments)	1	cloned	No	BA_3309	30257855		hypothetical protein BA_3309 [Bacillus a...	31	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05007 (show subtarget assignments)	1	cloned	No	BA_3383	30257926		putative lipoprotein [Bacillus anthracis...	236	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05251 (show subtarget assignments)	1	cloned	No	lmo2747	16804784	serS	seryl-tRNA synthetase [Listeria monocyto...	427	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2DQ3	56.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05002 (show subtarget assignments)	1	cloned	No	lmo0086	16802134	-	hypothetical protein lmo0086 [Listeria m...	1959	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TUF	2.8%	Listeria monocytogenes

IDP05005 (show subtarget assignments)	1	cloned	No	CDP11	110666933		hypothetical protein CDP11 [Clostridium ...	33	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05004 (show subtarget assignments)	1	cloned	No	CDP01	110666923		hypothetical protein CDP01 [Clostridium ...	33	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05006 (show subtarget assignments)	1	cloned	No	BA_3083	30257668		putative lipoprotein [Bacillus anthracis...	56	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP91430 (show subtarget assignments)	8	cloned	No	VV1_0534	27363997		ATP-dependent RNA helicase SrmB [Vibrio ...	408	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2I4I	32.8%	Vibrio vulnificus

IDP05590 (show subtarget assignments)	1	soluble	No	BA_2986	30257575		putative lipoprotein [Bacillus anthracis...	189	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05014 (show subtarget assignments)	1	soluble	No	BA_1972	30256627		putative lipoprotein [Bacillus anthracis...	765	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP04046 (show subtarget assignments)	1	cloned	No	YPCD1.78c	16082765	tap	repA translation protein [Yersinia pesti...	24	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP05340 (show subtarget assignments)	1	in_pdb 3UUW	Yes	CD3450	126701073		putative oxidoreductase [Clostridium dif...	305	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3UUW	100%	Clostridium difficile	Cellular processes: Pathogenesis

IDP05256 (show subtarget assignments)	1	cloned	No	BA_1805	30256080		hypothetical protein BA_1805 [Bacillus a...	44	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05206 (show subtarget assignments)	1	cloned	No	CD2247	126699865	cspBA	putative germination-specific protease [...	1132	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3I6S	10.5%	Clostridium difficile	Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05637 (show subtarget assignments)	1	cloned	No	CD2518	126700135		cell surface protein [Clostridium diffic...	456	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP05684 (show subtarget assignments)	1	in_pdb 3TNG 3U9E 3UF6	No	lmo1369	16803409	-	hypothetical protein lmo1369 [Listeria m...	288	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3TNG	100%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP04210 (show subtarget assignments)	1	expressed	No	ZZZ_0017				243	Effector protein	Phase 4: April 2009	2KXC	18.5%	Escherichia coli

IDP05011 (show subtarget assignments)	1	soluble	No	BA_4970	30259463		hypothetical protein BA_4970 [Bacillus a...	139	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05013 (show subtarget assignments)	1	expressed	No	CD0238	126697809		hypothetical protein CD0238 [Clostridium...	111	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP04537 (show subtarget assignments)	8	selected	No	CAC05780	12329049	virF	VirF, member of the AraC family of trans...	262	Shigella effector protein	Community Requests	3GBG	26.3%	Shigella flexneri

IDP05012 (show subtarget assignments)	1	cloned	No	BA_5070	30259559		cell wall surface anchor family protein ...	148	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05746 (show subtarget assignments)	1	cloned	No	CD3402	126701025	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	317	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3TX1	43.1%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05522 (show subtarget assignments)	1	cloned	No	CD2240	126699857	nanA	N-acetylneuraminate lyase [Clostridium d...	302	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5Z	69.9%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP05061 (show subtarget assignments)	1	cloned	No	CD1631	126699235	sodA	superoxide dismutase (Mn) [Clostridium d...	234	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2RCV	47%	Clostridium difficile	Cellular processes: Detoxification

IDP04336 (show subtarget assignments)	8	in_crystallization_trials	No	CAC05790	12329059	ospC1	OspC1, secreted by the Mxi-Spa secretion...	470	Shigella effector protein	Community Requests			Shigella flexneri

IDP05036 (show subtarget assignments)	1	cloned	No	BA_1663	30255960		hypothetical protein BA_1663 [Bacillus a...	450	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05023 (show subtarget assignments)	1	expressed	No	BAS2353	49185362	-	hemolysin II, C-terminal [Bacillus anthr...	240	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3ANZ	27.9%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP05018 (show subtarget assignments)	1	purified	No	BA_2679	30257293		hypothetical protein BA_2679 [Bacillus a...	47	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05263 (show subtarget assignments)	1	cloned	No	CD2793	126700409	slpA	cell surface protein (S-layer precursor ...	719	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3CVZ	36.4%	Clostridium difficile	Cell envelope: Other

IDP04038 (show subtarget assignments)	1	expressed	No	YPCD1.65	5832485	YPCD1.65	putative transposase [Yersinia pestis CO...	102	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP05016 (show subtarget assignments)	1	soluble	No	BA_2056	30256706		putative lipoprotein [Bacillus anthracis...	59	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05015 (show subtarget assignments)	1	cloned	No	CD0247	126697818	fliE	flagellar hook-basal body protein FliE [...	105	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05285 (show subtarget assignments)	1	selected	No	CD0663	126698240	tcdA	toxin A [Clostridium difficile 630]	2710	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3SRZ	20%	Clostridium difficile	Cellular processes: Pathogenesis

IDP05399 (show subtarget assignments)	1	expressed	No	BA_3541	30258076		conserved domain protein [Bacillus anthr...	170	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Domain

IDP05022 (show subtarget assignments)	1	cloned	No	CD1145	126698740	mreB2	rod shape-determining protein MreB [Clos...	353	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JCE	54.4%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05255 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0663	57650073	argS	arginyl-tRNA synthetase [Staphylococcus ...	553	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05270 (show subtarget assignments)	1	soluble	No	lmo1016	16803056	gbuC	hypothetical protein lmo1016 [Listeria m...	249	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2B4L	51%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP05021 (show subtarget assignments)	1	soluble	No	CD1139	126698733	rnfG	electron transport complex protein [Clos...	189	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05020 (show subtarget assignments)	1	soluble	No	CD1027	126698611	potD	spermidine/putrescine ABC transporter,su...	350	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EQB	39.1%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05019 (show subtarget assignments)	1	expressed	No	CD0267	126697839		hypothetical protein CD0267 [Clostridium...	145	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05587 (show subtarget assignments)	1	soluble	No	BA_2748	30257353	sleB	spore cortex-lytic enzyme prepeptide [Ba...	253	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3BKH	19.8%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP05343 (show subtarget assignments)	1	soluble	No	Z1544	12514412		putative acyl-carrier protein synthase [...	122	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1FTE	36.1%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP05477 (show subtarget assignments)	1	cloned	No	BA_2770	30257374		hypothetical protein BA_2770 [Bacillus a...	38	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05264 (show subtarget assignments)	1	expressed	No	CD3257	126700876		putative polysaccharide deacetylase [Clo...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1W17	25.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05025 (show subtarget assignments)	1	cloned	No	BAS4742	49187733	-	hypothetical protein BAS4742 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05262 (show subtarget assignments)	1	in_pdb 4EBH 3SRT	No	CD0872	126698449	maa	maltose O-acetyltransferase [Clostridium...	185	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3SRT	100%	Clostridium difficile	Cellular processes: Detoxification

IDP05034 (show subtarget assignments)	1	soluble	No	BA_1274	30255223		conserved hypothetical protein [Bacillus...	119	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP04536 (show subtarget assignments)	8	selected	No	CAC05826	12329095	spa32	Spa32, secreted by and component of the ...	292	Shigella effector protein	Community Requests			Shigella flexneri

IDP05258 (show subtarget assignments)	1	soluble	No	CD2761	126700377		putative N-acetylmuramoyl-L-alanine amid...	301	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JWQ	23.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05026 (show subtarget assignments)	1	cloned	No	BA_0025	30253539		putative csfB protein [Bacillus anthraci...	59	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: General

IDP04209 (show subtarget assignments)	1	soluble	No	Z5142	15804250		hypothetical protein Z5142 [Escherichia ...	398	Effector protein	Phase 4: April 2009	3PCR	89.7%	Escherichia coli

IDP05027 (show subtarget assignments)	1	purified	No	BA_0231	30253731		putative oligopeptide ABC transporter, o...	555	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRF	27.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04107 (show subtarget assignments)	1	purified	No	BAS0120	49183154		50S ribosomal protein L14 [Bacillus anth...	122	Proposed to be essential proteins	Phase 4: April 2009	1C04	86.9%	Bacillus anthracis

IDP05257 (show subtarget assignments)	1	crystallized	No	CD2748	126700363		putative transferase [Clostridium diffic...	165	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2EG0	48.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP05195 (show subtarget assignments)	1	soluble	No	CD0873	126698450		ABC transporter, substrate-binding lipop...	340	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3LKV	32.9%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05341 (show subtarget assignments)	1	cloned	No	lmo1928	16803967	aroF	chorismate synthase [Listeria monocytoge...	388	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1QXO	63.1%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP05029 (show subtarget assignments)	1	cloned	No	BA_0864	30254614		putative lipoprotein [Bacillus anthracis...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05261 (show subtarget assignments)	1	cloned	No	CD2772	126700388	tuaG	putative teichuronic acid biosynthesis g...	212	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3BCV	23.6%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04045 (show subtarget assignments)	1	soluble	No	FTT1747	56708745		outer membrane protein [Francisella tula...	191	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Francisella tularensis

IDP05734 (show subtarget assignments)	1	cloned	No	CD1470	126699074		putative phage shock protein [Clostridiu...	99	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3GK5	33.3%	Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP04106 (show subtarget assignments)	1	cloned	No	BAS0124	49183158		30S ribosomal protein S8 [Bacillus anthr...	132	Proposed to be essential proteins	Phase 4: April 2009	1SEI	85.6%	Bacillus anthracis

IDP05028 (show subtarget assignments)	1	purified	No	BA_0331	30253869		polysaccharide deacetylase-like protein ...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: General

IDP04529 (show subtarget assignments)	1	crystallized	No	STM2481_1_1037	16765801	acrD	aminoglycoside/multidrug efflux system [...	1037	Salmonella essential protein	Phase 4: April 2009	1IWG	66.2%	Salmonella enterica

IDP05342 (show subtarget assignments)	1	soluble	No	YPO3398	16123547	-	glutamyl-Q tRNA(Asp) synthetase [Yersini...	384	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	52.1%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP91473 (show subtarget assignments)	8	expressed	No	VPA1342	28901197		type III secretion system protein [Vibri...	243	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP91472 (show subtarget assignments)	8	cloned	No	VPA1354	28901209		putative type III secretion system EscU ...	352	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3BZP	13.4%	Vibrio parahaemolyticus

IDP04707
(show subtarget assignments)

1

cloned

No

BAS0113

49183147

50S ribosomal protein L2 [Bacillus anthr...

276

Proposed to be essential proteins

Phase 4: April 2009

1VSA

65%

Bacillus anthracis

IDP05393
(show subtarget assignments)

1

expressed

No

BA_3225

30257788

hypothetical protein BA_3225 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05638
(show subtarget assignments)

1

cloned

No

CD2546

126700163

endoglucanase (cellulase) [Clostridium d...

340

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3AMC

39.7%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05349
(show subtarget assignments)

1

cloned

No

CD2487

126700104

PTS system, IIB component [Clostridium d...

105

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KYR

67.6%

Clostridium difficile

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP05247
(show subtarget assignments)

1

cloned

No

lmo2636

16804674

-

hypothetical protein lmo2636 [Listeria m...

360

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VRM

29.4%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04211
(show subtarget assignments)

1

expressed

No

STM0408_1_323

16763788

secF

preprotein translocase subunit SecF [Sal...

323

Salmonella essential protein

Phase 4: April 2009

3AQP

35.3%

Salmonella enterica

IDP05345
(show subtarget assignments)

1

soluble

No

Z3383

12516442

pbpG

penicillin-binding protein 7 [Escherichi...

313

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1XP4

25.9%

Escherichia coli

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05332
(show subtarget assignments)

1

soluble

No

Z4866

12518154

putative beta-ketoacyl-ACP synthase [Esc...

409

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

4EWG

59.7%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP05331
(show subtarget assignments)

1

soluble

No

SACOL0009

57651117

serS

seryl-tRNA synthetase [Staphylococcus au...

428

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2DQ3

51.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05248
(show subtarget assignments)

1

expressed

No

lmo2691

16804728

-

autolysin [Listeria monocytogenes EGD-e]...

590

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

16.1%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05515
(show subtarget assignments)

1

cloned

No

CD1687

126699293

putative lipoprotein [Clostridium diffic...

278

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP04731
(show subtarget assignments)

1

crystallized

No

BAS3675

49186674

ribosome recycling factor [Bacillus anth...

185

Proposed to be essential proteins

Phase 4: April 2009

1IS1

50.8%

Bacillus anthracis

IDP05338
(show subtarget assignments)

1

cloned

No

lmo1598

16803638

tyrS

tyrosyl-tRNA synthetase [Listeria monocy...

419

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2TS1

62.8%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05403
(show subtarget assignments)

1

soluble

No

BA_4464

30258958

comGC

comG operon protein 3 [Bacillus anthraci...

99

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: DNA transformation

IDP04728
(show subtarget assignments)

1

selected

No

BAS0102

49183136

DNA-directed RNA polymerase subunit beta...

1177

Proposed to be essential proteins

Phase 4: April 2009

1HQM

49.2%

Bacillus anthracis

IDP91004
(show subtarget assignments)

8

soluble

No

y1935

22125827

cysteine desulfurase activator complex s...

503

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

4DN7

18.7%

Yersinia pestis

IDP05253
(show subtarget assignments)

1

cloned

No

CD0259

126697831

putative flagellar protein [Clostridium ...

107

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05250
(show subtarget assignments)

1

soluble

No

lmo2446

16804484

-

hypothetical protein lmo2446 [Listeria m...

1091

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2X2H

19%

Listeria monocytogenes

Central intermediary metabolism: Other

IDP05009
(show subtarget assignments)

1

soluble

No

BA_4237

30258740

putative lipoprotein [Bacillus anthracis...

253

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP04730
(show subtarget assignments)

1

cloned

No

BAS4284

49187280

alanyl-tRNA synthetase [Bacillus anthrac...

880

Proposed to be essential proteins

Phase 4: April 2009

1RIQ

26.3%

Bacillus anthracis

IDP05336
(show subtarget assignments)

1

soluble

No

Cj0799c

6968240

ruvA

hypothetical protein Cj0794 [Campylobact...

183

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

32.5%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP05335
(show subtarget assignments)

1

expressed

No

BAS2222

49185231

-

threonyl-tRNA synthetase [Bacillus anthr...

639

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NYQ

50.5%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP05517
(show subtarget assignments)

1

soluble

No

CD1699

126699305

ribB

riboflavin synthase subunit alpha [Clost...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KZL

38.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05334
(show subtarget assignments)

1

soluble

No

SACOL1808

57652056

leuS

leucyl-tRNA synthetase [Staphylococcus a...

805

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H3N

46.4%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP91001
(show subtarget assignments)

8

soluble

No

y1897

22125790

yfeA

periplasmic-binding protein [Yersinia pe...

323

virulence/pathogenesis / periplasmic iron-binding protein

Community Requests

1XVL

52.9%

Yersinia pestis

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP05252
(show subtarget assignments)

1

soluble

No

lmo2854

16804891

-

hypothetical protein lmo2854 [Listeria m...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Cell envelope: Other

IDP05681
(show subtarget assignments)

1

cloned

No

lmo1277

16803317

codV

hypothetical protein lmo1277 [Listeria m...

300

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1A0P

35%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Prophage functions

IDP05392
(show subtarget assignments)

1

cloned

No

BA_3222

30257786

hypothetical protein BA_3222 [Bacillus a...

56

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP04013
(show subtarget assignments)

1

cloned

No

STM2913_1_498

16766219

putative permease [Salmonella typhimuriu...

498

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP05516
(show subtarget assignments)

1

soluble

No

CD1697

126699303

ribH

riboflavin synthase beta chain (6,7-dime...

158

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RVV

66.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05337
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1282

57651833

proS

prolyl-tRNA synthetase [Staphylococcus a...

567

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2J3L

55.7%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05001
(show subtarget assignments)

1

purified

No

BA_1090

30254820

putative lipoprotein [Bacillus anthracis...

142

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP04732
(show subtarget assignments)

1

cloned

No

BAS5341

49188325

50S ribosomal protein L34 [Bacillus anth...

44

Proposed to be essential proteins

Phase 4: April 2009

1NKW

65.9%

Bacillus anthracis

IDP05003
(show subtarget assignments)

1

cloned

No

BA_3309

30257855

hypothetical protein BA_3309 [Bacillus a...

31

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05007
(show subtarget assignments)

1

cloned

No

BA_3383

30257926

putative lipoprotein [Bacillus anthracis...

236

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05251
(show subtarget assignments)

1

cloned

No

lmo2747

16804784

serS

seryl-tRNA synthetase [Listeria monocyto...

427

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2DQ3

56.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05002
(show subtarget assignments)

1

cloned

No

lmo0086

16802134

-

hypothetical protein lmo0086 [Listeria m...

1959

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TUF

2.8%

Listeria monocytogenes

IDP05005
(show subtarget assignments)

1

cloned

No

CDP11

110666933

hypothetical protein CDP11 [Clostridium ...

33

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05004
(show subtarget assignments)

1

cloned

No

CDP01

110666923

hypothetical protein CDP01 [Clostridium ...

33

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05006
(show subtarget assignments)

1

cloned

No

BA_3083

30257668

putative lipoprotein [Bacillus anthracis...

56

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP91430
(show subtarget assignments)

8

cloned

No

VV1_0534

27363997

ATP-dependent RNA helicase SrmB [Vibrio ...

408

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2I4I

32.8%

Vibrio vulnificus

IDP05590
(show subtarget assignments)

1

soluble

No

BA_2986

30257575

putative lipoprotein [Bacillus anthracis...

189

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05014
(show subtarget assignments)

1

soluble

No

BA_1972

30256627

putative lipoprotein [Bacillus anthracis...

765

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP04046
(show subtarget assignments)

1

cloned

No

YPCD1.78c

16082765

tap

repA translation protein [Yersinia pesti...

24

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP05340
(show subtarget assignments)

1

in_pdb
3UUW

Yes

CD3450

126701073

putative oxidoreductase [Clostridium dif...

305

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3UUW

100%

Clostridium difficile

Cellular processes: Pathogenesis

IDP05256
(show subtarget assignments)

1

cloned

No

BA_1805

30256080

hypothetical protein BA_1805 [Bacillus a...

44

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05206
(show subtarget assignments)

1

cloned

No

CD2247

126699865

cspBA

putative germination-specific protease [...

1132

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3I6S

10.5%

Clostridium difficile

Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05637
(show subtarget assignments)

1

cloned

No

CD2518

126700135

cell surface protein [Clostridium diffic...

456

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP05684
(show subtarget assignments)

1

in_pdb
3TNG
3U9E
3UF6

No

lmo1369

16803409

-

hypothetical protein lmo1369 [Listeria m...

288

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3TNG

100%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP04210
(show subtarget assignments)

1

expressed

No

ZZZ_0017

243

Effector protein

Phase 4: April 2009

2KXC

18.5%

Escherichia coli

IDP05011
(show subtarget assignments)

1

soluble

No

BA_4970

30259463

hypothetical protein BA_4970 [Bacillus a...

139

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05013
(show subtarget assignments)

1

expressed

No

CD0238

126697809

hypothetical protein CD0238 [Clostridium...

111

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP04537
(show subtarget assignments)

8

selected

No

CAC05780

12329049

virF

VirF, member of the AraC family of trans...

262

Shigella effector protein

Community Requests

3GBG

26.3%

Shigella flexneri

IDP05012
(show subtarget assignments)

1

cloned

No

BA_5070

30259559

cell wall surface anchor family protein ...

148

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05746
(show subtarget assignments)

1

cloned

No

CD3402

126701025

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

317

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3TX1

43.1%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05522
(show subtarget assignments)

1

cloned

No

CD2240

126699857

nanA

N-acetylneuraminate lyase [Clostridium d...

302

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5Z

69.9%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP05061
(show subtarget assignments)

1

cloned

No

CD1631

126699235

sodA

superoxide dismutase (Mn) [Clostridium d...

234

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2RCV

47%

Clostridium difficile

Cellular processes: Detoxification

IDP04336
(show subtarget assignments)

8

in_crystallization_trials

No

CAC05790

12329059

ospC1

OspC1, secreted by the Mxi-Spa secretion...

470

Shigella effector protein

Community Requests

Shigella flexneri

IDP05036
(show subtarget assignments)

1

cloned

No

BA_1663

30255960

hypothetical protein BA_1663 [Bacillus a...

450

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05023
(show subtarget assignments)

1

expressed

No

BAS2353

49185362

-

hemolysin II, C-terminal [Bacillus anthr...

240

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3ANZ

27.9%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP05018
(show subtarget assignments)

1

purified

No

BA_2679

30257293

hypothetical protein BA_2679 [Bacillus a...

47

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05263
(show subtarget assignments)

1

cloned

No

CD2793

126700409

slpA

cell surface protein (S-layer precursor ...

719

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3CVZ

36.4%

Clostridium difficile

Cell envelope: Other

IDP04038
(show subtarget assignments)

1

expressed

No

YPCD1.65

5832485

YPCD1.65

putative transposase [Yersinia pestis CO...

102

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP05016
(show subtarget assignments)

1

soluble

No

BA_2056

30256706

putative lipoprotein [Bacillus anthracis...

59

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05015
(show subtarget assignments)

1

cloned

No

CD0247

126697818

fliE

flagellar hook-basal body protein FliE [...

105

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05285
(show subtarget assignments)

1

selected

No

CD0663

126698240

tcdA

toxin A [Clostridium difficile 630]

2710

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3SRZ

20%

Clostridium difficile

Cellular processes: Pathogenesis

IDP05399
(show subtarget assignments)

1

expressed

No

BA_3541

30258076

conserved domain protein [Bacillus anthr...

170

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Domain

IDP05022
(show subtarget assignments)

1

cloned

No

CD1145

126698740

mreB2

rod shape-determining protein MreB [Clos...

353

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JCE

54.4%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05255
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0663

57650073

argS

arginyl-tRNA synthetase [Staphylococcus ...

553

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05270
(show subtarget assignments)

1

soluble

No

lmo1016

16803056

gbuC

hypothetical protein lmo1016 [Listeria m...

249

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2B4L

51%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP05021
(show subtarget assignments)

1

soluble

No

CD1139

126698733

rnfG

electron transport complex protein [Clos...

189

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05020
(show subtarget assignments)

1

soluble

No

CD1027

126698611

potD

spermidine/putrescine ABC transporter,su...

350

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EQB

39.1%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05019
(show subtarget assignments)

1

expressed

No

CD0267

126697839

hypothetical protein CD0267 [Clostridium...

145

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05587
(show subtarget assignments)

1

soluble

No

BA_2748

30257353

sleB

spore cortex-lytic enzyme prepeptide [Ba...

253

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3BKH

19.8%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP05343
(show subtarget assignments)

1

soluble

No

Z1544

12514412

putative acyl-carrier protein synthase [...

122

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1FTE

36.1%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP05477
(show subtarget assignments)

1

cloned

No

BA_2770

30257374

hypothetical protein BA_2770 [Bacillus a...

38

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05264
(show subtarget assignments)

1

expressed

No

CD3257

126700876

putative polysaccharide deacetylase [Clo...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1W17

25.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05025
(show subtarget assignments)

1

cloned

No

BAS4742

49187733

-

hypothetical protein BAS4742 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05262
(show subtarget assignments)

1

in_pdb
4EBH
3SRT

No

CD0872

126698449

maa

maltose O-acetyltransferase [Clostridium...

185

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3SRT

100%

Clostridium difficile

Cellular processes: Detoxification

IDP05034
(show subtarget assignments)

1

soluble

No

BA_1274

30255223

conserved hypothetical protein [Bacillus...

119

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP04536
(show subtarget assignments)

8

selected

No

CAC05826

12329095

spa32

Spa32, secreted by and component of the ...

292

Shigella effector protein

Community Requests

Shigella flexneri

IDP05258
(show subtarget assignments)

1

soluble

No

CD2761

126700377

putative N-acetylmuramoyl-L-alanine amid...

301

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JWQ

23.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05026
(show subtarget assignments)

1

cloned

No

BA_0025

30253539

putative csfB protein [Bacillus anthraci...

59

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: General

IDP04209
(show subtarget assignments)

1

soluble

No

Z5142

15804250

hypothetical protein Z5142 [Escherichia ...

398

Effector protein

Phase 4: April 2009

3PCR

89.7%

Escherichia coli

IDP05027
(show subtarget assignments)

1

purified

No

BA_0231

30253731

putative oligopeptide ABC transporter, o...

555

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRF

27.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04107
(show subtarget assignments)

1

purified

No

BAS0120

49183154

50S ribosomal protein L14 [Bacillus anth...

122

Proposed to be essential proteins

Phase 4: April 2009

1C04

86.9%

Bacillus anthracis

IDP05257
(show subtarget assignments)

1

crystallized

No

CD2748

126700363

putative transferase [Clostridium diffic...

165

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2EG0

48.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP05195
(show subtarget assignments)

1

soluble

No

CD0873

126698450

ABC transporter, substrate-binding lipop...

340

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3LKV

32.9%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05341
(show subtarget assignments)

1

cloned

No

lmo1928

16803967

aroF

chorismate synthase [Listeria monocytoge...

388

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1QXO

63.1%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP05029
(show subtarget assignments)

1

cloned

No

BA_0864

30254614

putative lipoprotein [Bacillus anthracis...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05261
(show subtarget assignments)

1

cloned

No

CD2772

126700388

tuaG

putative teichuronic acid biosynthesis g...

212

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3BCV

23.6%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04045
(show subtarget assignments)

1

soluble

No

FTT1747

56708745

outer membrane protein [Francisella tula...

191

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Francisella tularensis

IDP05734
(show subtarget assignments)

1

cloned

No

CD1470

126699074

putative phage shock protein [Clostridiu...

99

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3GK5

33.3%

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP04106
(show subtarget assignments)

1

cloned

No

BAS0124

49183158

30S ribosomal protein S8 [Bacillus anthr...

132

Proposed to be essential proteins

Phase 4: April 2009

1SEI

85.6%

Bacillus anthracis

IDP05028
(show subtarget assignments)

1

purified

No

BA_0331

30253869

polysaccharide deacetylase-like protein ...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: General

IDP04529
(show subtarget assignments)

1

crystallized

No

STM2481_1_1037

16765801

acrD

aminoglycoside/multidrug efflux system [...

1037

Salmonella essential protein

Phase 4: April 2009

1IWG

66.2%

Salmonella enterica

IDP05342
(show subtarget assignments)

1

soluble

No

YPO3398

16123547

-

glutamyl-Q tRNA(Asp) synthetase [Yersini...

384

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

52.1%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP91473
(show subtarget assignments)

8

expressed

No

VPA1342

28901197

type III secretion system protein [Vibri...

243

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP91472
(show subtarget assignments)

8

cloned

No

VPA1354

28901209

putative type III secretion system EscU ...

352

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3BZP

13.4%

Vibrio parahaemolyticus