Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04530 (show subtarget assignments)	1	soluble	No	STM2519_1_490	16765839	engA	GTP-binding protein EngA [Salmonella typ...	490	Salmonella essential protein	Phase 4: April 2009	2HJG	36.1%	Salmonella enterica

IDP90341 (show subtarget assignments)	8	expressed	No	CT049	15604768		hypothetical protein CT049 [Chlamydia tr...	490	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP01996 (show subtarget assignments)	1	in_crystallization_trials	No	STM3136	16766436		putative D-mannonate oxidoreductase [Sal...	490	Conserved; Drug target functions	Phase 3: June 2008	1LJ8	40.6%	Salmonella enterica	Energy metabolism	Other

IDP02719 (show subtarget assignments)	1	cloned	No	lmo0262	16802308	inlG	internalin G [Listeria monocytogenes EGD...	490	Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815	Phase 3: June 2008	1M9S	31.6%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP02223 (show subtarget assignments)	1	expressed	No	YPO0550	16120878	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	490	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1E8C	76.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01212 (show subtarget assignments)	1	expressed	No	BA_3024	30257611		glycosyl transferase, group 2 family pro...	490	Essential Gene	Phase 2: March 2008	3E25	9.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04364 (show subtarget assignments)	1	crystallized	No	VC0767	15640786		inositol-5-monophosphate dehydrogenase [...	489	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3TSB	56.6%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP91670 (show subtarget assignments)	8	selected	No	ANTR2_HUMAN	0			489	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SHU	37%	Homo sapiens

IDP02026 (show subtarget assignments)	1	crystallized	No	CBU_0123	29540743	murE	UDP-N-acetylmuramoylalanyl-D-glutamate-2...	489	Conserved; Drug target functions	Phase 3: June 2008	1E8C	41.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92108 (show subtarget assignments)	8	selected	No	TGME49_093180	237841645		NADP-specific glutamate dehydrogenase, p...	489	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2BMA	52.4%	Toxoplasma gondii

IDP02321 (show subtarget assignments)	1	cloned	No	FTT0077	56707256	sucB	dihydrolipoamide succinyltransferase com...	489	Conserved; Drug target functions	Phase 3: June 2008	1C4T	29.9%	Francisella tularensis	Energy metabolism	TCA cycle

IDP00159 (show subtarget assignments)	1	purified	No	VC0831	15640848	tcpC	toxin co-regulated pilus biosynthesis ou...	489	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP91582 (show subtarget assignments)	8	cloned	No	CBU_0295	29540908		hypothetical protein	489	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP01005 (show subtarget assignments)	1	in_crystallization_trials	No	STM2511	16765831	guaB	inositol-5-monophosphate dehydrogenase	488	Conserved Gene / Pathway	Phase 2: March 2008	3TSB	55.9%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00949 (show subtarget assignments)	1	purified	No	STM1102	16764460	hpaE	4-hydroxyphenylacetate catabolism	488	Conserved Gene / Pathway	Phase 2: March 2008	2D4E	47.7%	Salmonella enterica	Central intermediary metabolism	Other

IDP01148 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1159	30254878	katB	catalase	488	Conserved Gene / Pathway	Phase 2: March 2008	2J2M	64.8%	Bacillus anthracis	Cellular processes	Detoxification

IDP04595 (show subtarget assignments)	1	soluble	No	BAS0565	49183590		nicotinate phosphoribosyltransferase [Ba...	487	Proposed to be essential proteins	Phase 4: April 2009	2F7F	61.4%	Bacillus anthracis

IDP04352 (show subtarget assignments)	1	soluble	No	GBAA0584	47525859		sensor histidine kinase [Bacillus anthra...	487	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	17%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP91475 (show subtarget assignments)	8	expressed	No	VPA1339	28901194		putative type III secretion system EscC ...	487	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP91181 (show subtarget assignments)	8	cloned	No	CT578	3329020		wall surface anchor family protein [Chla...	487	virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...	Community Requests			Chlamydia trachomatis

IDP01777 (show subtarget assignments)	1	cloned	No	CBU_0313	29540926		transglycosylase, Slt family [Coxiella b...	487	Conserved; Drug target functions	Phase 3: June 2008	1QSA	9.9%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91416 (show subtarget assignments)	8	cloned	No	VV1_0692	27364149		RNA polymerase factor sigma-54 [Vibrio v...	487	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2AHQ	7.2%	Vibrio vulnificus

IDP04126 (show subtarget assignments)	1	cloned	No	YPO2871	115348542	guaB	inosine-5'-monophosphate dehydrogenase [...	487	conserved gene; putative drug target function;	Phase 4: April 2009	1ZFJ	56.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01178 (show subtarget assignments)	1	in_pdb 3TSB 3TSD	Yes	BA_0008	30253523	guaB	inosine-5'-monophosphate dehydrogenase	487	Conserved Gene / Pathway	Phase 2: March 2008	3TSB	100%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP05668 (show subtarget assignments)	1	soluble	No	lmo0576	16802619	-	hypothetical protein lmo0576 [Listeria m...	487	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KT7	6%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP04386 (show subtarget assignments)	1	cloned	No	YPO3230	218930257	pepD	aminoacyl-histidine dipeptidase [Yersini...	486	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3MRU	63%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00225 (show subtarget assignments)	1	cloned	No	YPO3069	16123246	-	putative exported protein	486	Virulence	Phase 1: October 2007	3C37	15%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP00173 (show subtarget assignments)	1	cloned	No	YPO2922	16123109	-	putative membrane protein	486	Virulence	Phase 1: October 2007	3K4U	14.4%	Yersinia pestis	Unknown function	General

IDP90586 (show subtarget assignments)	8	cloned	No	YPO2188	16122418	cls	cardiolipin synthetase [Yersinia pestis ...	486	Predicted Essential	Community Requests			Yersinia pestis

IDP05694 (show subtarget assignments)	1	soluble	No	lmo2007	16804046	-	hypothetical protein lmo2007 [Listeria m...	485	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3OMB	21.3%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP90125 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_038	68449112		kelch-like protein [Monkeypox virus]	485	similar to VACV-COP-F3L, MPXV-ZAI96-C9L	Community Requests	1ZGK	13.6%	Monkeypox virus

IDP90781 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1058c	15792385	guaB	inositol-5-monophosphate dehydrogenase [...	485	Predicted Essential	Community Requests	3TSB	61.6%	Campylobacter jejuni

IDP04577 (show subtarget assignments)	1	cloned	No	BAS0087	49183121		glutamyl-tRNA synthetase [Bacillus anthr...	485	Proposed to be essential proteins	Phase 4: April 2009	2O5R	44.4%	Bacillus anthracis

IDP05769 (show subtarget assignments)	1	cloned	No	SACOL0574	57651404	gltX	glutamyl-tRNA synthetase [Staphylococcus...	484	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2O5R	43.2%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP04183 (show subtarget assignments)	1	expressed	No	VCA0257	15601025		sensor histidine kinase [Vibrio cholerae...	484	drug target; putative drug target function;	Phase 4: April 2009			Vibrio cholerae	Regulatory functions	Other

IDP02394 (show subtarget assignments)	1	cloned	No	YPO1633	16121901	phoQ	sensor protein PhoQ [Yersinia pestis CO9...	484	Conserved; CD; Drug target functions	Phase 3: June 2008	1ID0	20.9%	Yersinia pestis	Regulatory functions	Other

IDP05067 (show subtarget assignments)	1	cloned	No	CD2664	126700278	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	484	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2WTZ	36.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04376 (show subtarget assignments)	1	crystallized	No	CPF_2558	110800169	guaB	inositol-5-monophosphate dehydrogenase [...	484	conserved gene; putative drug target function;	Phase 4: April 2009	3TSB	67.4%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP91035 (show subtarget assignments)	8	selected	No	SDY_P070	82524476	ospC2	OspC2 [Shigella dysenteriae Sd197]	484	virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...	Community Requests			Shigella dysenteriae

IDP92094 (show subtarget assignments)	8	selected	No	TGME49_038190	237834427		DNA-directed RNA polymerase II, putative...	484	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1I3Q	20.7%	Toxoplasma gondii

IDP91468 (show subtarget assignments)	8	cloned	No	VPA1370	28901226		hypothetical protein VPA1370 [Vibrio par...	484	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3RYL	49.4%	Vibrio parahaemolyticus

IDP91036 (show subtarget assignments)	8	selected	No	SDY_P151	82524557	ospC3	OspC3 [Shigella dysenteriae Sd197]	484	virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...	Community Requests			Shigella dysenteriae

IDP04430 (show subtarget assignments)	1	purified	No	GBAA4921	47530215		sensor histidine kinase [Bacillus anthra...	484	putative drug target function;	Phase 4: April 2009	2C2A	16.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP01664 (show subtarget assignments)	1	purified	No	Cj0064c	15791456	flhF	flagellar biosynthesis regulator FlhF [C...	484	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1ZU4	17.4%	Campylobacter jejuni	Cell envelope	Surface structures

IDP04014 (show subtarget assignments)	1	purified	No	YPO3173	115348814	thiI	thiamine biosynthesis protein [Yersinia ...	483	conserved gene; putative drug target function;	Phase 4: April 2009	2C5S	23.6%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP90216 (show subtarget assignments)	8	expressed	No	MYXV_gp008	9633799	m005L	m005L, m5, M-T5	483	ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.	Community Requests	1N0R	8.5%	Myxoma virus	host range factor, host defense modulator	0

IDP04343 (show subtarget assignments)	1	expressed	No	YPO2916	218929972		two-component system sensor kinase [Yers...	483	putative drug target function;	Phase 4: April 2009	3A0R	13.5%	Yersinia pestis	Regulatory functions	Other

IDP00184 (show subtarget assignments)	1	cloned	No	YPO0624	16120950	-	putative membrane protein	483	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP92095 (show subtarget assignments)	8	selected	No	TGME49_046920	237835543		glutathione reductase, putative [Toxopla...	483	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1GER	46.2%	Toxoplasma gondii

IDP04329 (show subtarget assignments)	1	expressed	No	CPF_1466	110801108		putative lipoprotein [Clostridium perfri...	483	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04525 (show subtarget assignments)	1	cloned	No	STM1556_1_483	16764900		putative Na+/H+ antiporter [Salmonella t...	483	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP01168 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0084	47566748		capsule synthesis trans-acting positive ...	483	Virulence Associated Factor	Phase 2: March 2008	3SQN	8.5%	Bacillus anthracis

IDP04378 (show subtarget assignments)	1	cloned	No	CPF_2335	110799804		extracellular solute-binding protein [Cl...	482	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP01015 (show subtarget assignments)	0	work_stopped	No	STM2791	16766102	gabD	succinate-semialdehyde dehydrogenase I	482	Conserved Gene / Pathway	Phase 2: March 2008	3JZ4	90%	Salmonella enterica	Central intermediary metabolism	Other

IDP00535 (show subtarget assignments)	1	purified	No	YPO3506	16123652	dacB	D-alanyl-D-alanine carboxypeptidase/endo...	482	Drug Target Function	Phase 2: March 2008	2EX2	77.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04012 (show subtarget assignments)	1	cloned	No	CPF_2355	110800506	virJ	sensor histidine kinase [Clostridium per...	482	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	15.4%	Clostridium perfringens	Cellular processes	Pathogenesis

IDP90426 (show subtarget assignments)	8	cloned	No	CT_863	3329337		hypothetical protein [Chlamydia trachoma...	482	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP02632 (show subtarget assignments)	1	cloned	No	lmo0582	16802625	iap	P60 extracellular protein, invasion asso...	482	Known virulence-Invasion; Possible Vaccine Candidate; Known Essential Genes; PMI...	Phase 3: June 2008	3H41	14.1%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP01167 (show subtarget assignments)	1	expressed	No	GBAA_pXO2_0060	47566729		capsule synthesis trans-acting positive ...	482	Virulence Associated Factor	Phase 2: March 2008	3SQN	22%	Bacillus anthracis

IDP00557 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3382	16123531	gsrA	serine endoprotease	481	Virulence Associated Factor	Phase 2: March 2008	2ZLE	71.9%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP91986 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100006694	298255280		capsule biosynthesis integral membrane r...	481	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2XXP	74.6%	Streptococcus pneumoniae

IDP90595 (show subtarget assignments)	8	expressed	No	YPO2298	16122522	phoA	alkaline phosphatase [Yersinia pestis CO...	481	Predicted Essential	Community Requests	1B8J	70.7%	Yersinia pestis

IDP01253 (show subtarget assignments)	1	cloned	No	BA_2575	30257197		penicillin-binding protein, putative	481	Drug Target Function	Phase 2: March 2008	2QMI	20%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90188 (show subtarget assignments)	8	cloned	No	AAM13496.1	20153035	CPXV050 CDS	CPXV050 protein	480	kelch-like protein	Community Requests	3II7	12.3%	Cowpox virus	conserved hypothetical proteins	0

IDP91823 (show subtarget assignments)	8	soluble	No	b1854	1788160	pykA	pyruvate kinase II [Escherichia coli str...	480	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	2E28	40.6%	Escherichia coli

IDP04305 (show subtarget assignments)	1	cloned	No	CPF_2386	110798631		ribonuclease [Clostridium perfringens AT...	480	conserved gene; putative drug target function;	Phase 4: April 2009	2BX2	27.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04433 (show subtarget assignments)	1	cloned	No	GBAA5276	47530584		sensor histidine kinase [Bacillus anthra...	480	putative drug target function;	Phase 4: April 2009	3A0R	13.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP91676 (show subtarget assignments)	8	selected	No	DNJA3_HUMAN	0			480	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	3LZ8	19.6%	Homo sapiens

IDP92099 (show subtarget assignments)	8	selected	No	TGME49_105460	237842063		methionine aminopeptidase, type II, puta...	480	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1B6A	44.8%	Toxoplasma gondii

IDP00420 (show subtarget assignments)	1	purified	No	YPO1207	16121498	katA	catalase	480	Virulence Associated Factor	Phase 2: March 2008	1M85	84.2%	Yersinia pestis	Cellular processes	Detoxification

IDP05635 (show subtarget assignments)	1	cloned	No	CD2193	126699809		cell surface protein [Clostridium diffic...	480	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP91190 (show subtarget assignments)	1	in_crystallization_trials	No	EF_A0061	29345308		6'-aminoglycoside N-acetyltransferase [E...	479	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3R6Z	20%	Enterococcus faecalis

IDP01039 (show subtarget assignments)	1	expressed	No	STM2934	16766240	cysN	sulfate adenylyltransferase subunit 1	479	Conserved Gene / Pathway	Phase 2: March 2008	1ZUN	52.4%	Salmonella enterica	Central intermediary metabolism	Sulfur metabolism

IDP02653 (show subtarget assignments)	1	in_crystallization_trials	No	STM2840	16766146		anaerobic nitric oxide reductase flavoru...	479	Conserved; Drug target functions	Phase 3: June 2008	1YCF	33.8%	Salmonella enterica	Energy metabolism	Electron transport

IDP02398 (show subtarget assignments)	1	in_pdb 3PEI	Yes	FTT1318c	56708375	pepA	cytosol aminopeptidase [Francisella tula...	479	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3PEI	100%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91171 (show subtarget assignments)	8	expressed	No	CT_370	9087121		RecName: Full=Shikimate biosynthesis pro...	478	potential drug target / Shikimate pathway enzyme	Community Requests	2EGG	18.2%	Chlamydia trachomatis

IDP02192 (show subtarget assignments)	1	soluble	No	YPO0348	16120683	aspA	aspartate ammonia-lyase [Yersinia pestis...	478	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1JSW	89.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP02363 (show subtarget assignments)	1	purified	No	FTT1366c	56708419	pyk	pyruvate kinase [Francisella tularensis ...	478	Conserved; Drug target functions	Phase 3: June 2008	1E0U	39.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP04454 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1254	218928409	bglA	6-phospho-beta-glucosidase [Yersinia pes...	478	drug target; putative drug target function;	Phase 4: April 2009	2XHY	77.8%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP04213 (show subtarget assignments)	1	cloned	No	STM1003_1_478	16764363		putative transcriptional regulator [Salm...	478	Salmonella essential protein	Phase 4: April 2009			Salmonella enterica

IDP05109 (show subtarget assignments)	1	cloned	No	CD1987	126699595		cell surface protein [Clostridium diffic...	478	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP04247 (show subtarget assignments)	1	expressed	No	CPF_1402	110798994		sensor histidine kinase [Clostridium per...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	16.3%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP04630 (show subtarget assignments)	1	cloned	No	CBU_1228	29654531	qseC	sensor protein qseC [Coxiella burnetii R...	478	conserved gene; putative drug target function;	Phase 4: April 2009	3JZ3	19%	Coxiella burnetii	Regulatory functions	Other

IDP05700 (show subtarget assignments)	1	soluble	No	lmo2467	16804505	-	hypothetical protein lmo2467 [Listeria m...	478	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2BEM	18.2%	Listeria monocytogenes	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91185 (show subtarget assignments)	8	cloned	No	AAC46367	2352978			477	virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...	Community Requests	1NY5	31.9%	Vibrio cholerae

IDP91027 (show subtarget assignments)	8	expressed	No	y3600	22127474	uxaC	uronate isomerase [Yersinia pestis KIM]	477	other biological interest / -	Community Requests	3IAC	64.4%	Yersinia pestis

IDP04240 (show subtarget assignments)	1	cloned	No	CPF_1077	110800997		extracellular solute-binding protein [Cl...	477	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W7Y	15.3%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP02041 (show subtarget assignments)	1	in_crystallization_trials	No	STM3051	16766352	bglA	6-phospho-beta-glucosidase A [Salmonella...	477	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2XHY	95.4%	Salmonella enterica	Energy metabolism	Other

IDP02640 (show subtarget assignments)	1	purified	No	GBAA0609	47525887	aspA	aspartate ammonia-lyase [Bacillus anthra...	477	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1J3U	70.6%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP92093 (show subtarget assignments)	8	selected	No	TGME49_025050	237833761		adenosylhomocysteinase, putative [Toxopl...	477	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3OND	68.6%	Toxoplasma gondii

IDP01736 (show subtarget assignments)	1	expressed	No	GBAA5503	47530821		sensor histidine kinase [Bacillus anthra...	476	Conserved; Drug target functions	Phase 3: June 2008	2C2A	15.5%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP00574 (show subtarget assignments)	1	cloned	No	YPO0531	16120860	leuC	isopropylmalate isomerase large subunit ...	476	Virulence Associated Factor	Phase 2: March 2008	1ACO	25%	Yersinia pestis	Amino acid biosynthesis	Pyruvate family

IDP02485 (show subtarget assignments)	1	cloned	No	FTT1539c	56708571		hypothetical protein FTT1539c [Francisel...	476	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP00558 (show subtarget assignments)	1	purified	No	YPO0654	16120979	rfaE	bifunctional heptose 7-phosphate kinase/...	476	Conserved Gene / Pathway	Phase 2: March 2008	2FV7	16.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04189 (show subtarget assignments)	1	expressed	No	CPF_0225	110799110		sensor histidine kinase [Clostridium per...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	13%	Clostridium perfringens	Regulatory functions	Protein interactions

IDP90096 (show subtarget assignments)	8	expressed	No	ZZZ_0012				476	This protein is a component of a type VI secretion system of enteroaggregative E...	Community Requests			Escherichia coli

IDP00553 (show subtarget assignments)	1	expressed	No	YPO3939	16124067	glgA	glycogen synthase	476	Drug Target Function	Phase 2: March 2008	2QZS	71.4%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP91426 (show subtarget assignments)	8	cloned	No	VV1_0536	27363999		Na+/alanine symporter [Vibrio vulnificus...	476	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91408 (show subtarget assignments)	8	soluble	No	VV1_0725	27364179	cysN	sulfate adenylyltransferase subunit 1 [V...	476	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1ZUN	54.8%	Vibrio vulnificus

IDP05187 (show subtarget assignments)	1	cloned	No	CD0199	126697770		putative membrane-associated nucleotidas...	476	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GVE	19.5%	Clostridium difficile	Cell envelope: Other

IDP04530
(show subtarget assignments)

1

soluble

No

STM2519_1_490

16765839

engA

GTP-binding protein EngA [Salmonella typ...

490

Salmonella essential protein

Phase 4: April 2009

2HJG

36.1%

Salmonella enterica

IDP90341
(show subtarget assignments)

8

expressed

No

CT049

15604768

hypothetical protein CT049 [Chlamydia tr...

490

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP01996
(show subtarget assignments)

1

in_crystallization_trials

No

STM3136

16766436

putative D-mannonate oxidoreductase [Sal...

490

Conserved; Drug target functions

Phase 3: June 2008

1LJ8

40.6%

Salmonella enterica

Energy metabolism

Other

IDP02719
(show subtarget assignments)

1

cloned

No

lmo0262

16802308

inlG

internalin G [Listeria monocytogenes EGD...

490

Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815

Phase 3: June 2008

1M9S

31.6%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP02223
(show subtarget assignments)

1

expressed

No

YPO0550

16120878

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

490

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1E8C

76.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01212
(show subtarget assignments)

1

expressed

No

BA_3024

30257611

glycosyl transferase, group 2 family pro...

490

Essential Gene

Phase 2: March 2008

3E25

9.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04364
(show subtarget assignments)

1

crystallized

No

VC0767

15640786

inositol-5-monophosphate dehydrogenase [...

489

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3TSB

56.6%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP91670
(show subtarget assignments)

8

selected

No

ANTR2_HUMAN

0

489

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SHU

37%

Homo sapiens

IDP02026
(show subtarget assignments)

1

crystallized

No

CBU_0123

29540743

murE

UDP-N-acetylmuramoylalanyl-D-glutamate-2...

489

Conserved; Drug target functions

Phase 3: June 2008

1E8C

41.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92108
(show subtarget assignments)

8

selected

No

TGME49_093180

237841645

NADP-specific glutamate dehydrogenase, p...

489

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2BMA

52.4%

Toxoplasma gondii

IDP02321
(show subtarget assignments)

1

cloned

No

FTT0077

56707256

sucB

dihydrolipoamide succinyltransferase com...

489

Conserved; Drug target functions

Phase 3: June 2008

1C4T

29.9%

Francisella tularensis

Energy metabolism

TCA cycle

IDP00159
(show subtarget assignments)

1

purified

No

VC0831

15640848

tcpC

toxin co-regulated pilus biosynthesis ou...

489

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP91582
(show subtarget assignments)

8

cloned

No

CBU_0295

29540908

hypothetical protein

489

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP01005
(show subtarget assignments)

1

in_crystallization_trials

No

STM2511

16765831

guaB

inositol-5-monophosphate dehydrogenase

488

Conserved Gene / Pathway

Phase 2: March 2008

3TSB

55.9%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00949
(show subtarget assignments)

1

purified

No

STM1102

16764460

hpaE

4-hydroxyphenylacetate catabolism

488

Conserved Gene / Pathway

Phase 2: March 2008

2D4E

47.7%

Salmonella enterica

Central intermediary metabolism

Other

IDP01148
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1159

30254878

katB

catalase

488

Conserved Gene / Pathway

Phase 2: March 2008

2J2M

64.8%

Bacillus anthracis

Cellular processes

Detoxification

IDP04595
(show subtarget assignments)

1

soluble

No

BAS0565

49183590

nicotinate phosphoribosyltransferase [Ba...

487

Proposed to be essential proteins

Phase 4: April 2009

2F7F

61.4%

Bacillus anthracis

IDP04352
(show subtarget assignments)

1

soluble

No

GBAA0584

47525859

sensor histidine kinase [Bacillus anthra...

487

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

17%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP91475
(show subtarget assignments)

8

expressed

No

VPA1339

28901194

putative type III secretion system EscC ...

487

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP91181
(show subtarget assignments)

8

cloned

No

CT578

3329020

wall surface anchor family protein [Chla...

487

virulence/pathogenesis / Targets that are in a network of interactions with CT670 and CT671. These protei...

Community Requests

Chlamydia trachomatis

IDP01777
(show subtarget assignments)

1

cloned

No

CBU_0313

29540926

transglycosylase, Slt family [Coxiella b...

487

Conserved; Drug target functions

Phase 3: June 2008

1QSA

9.9%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91416
(show subtarget assignments)

8

cloned

No

VV1_0692

27364149

RNA polymerase factor sigma-54 [Vibrio v...

487

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2AHQ

7.2%

Vibrio vulnificus

IDP04126
(show subtarget assignments)

1

cloned

No

YPO2871

115348542

guaB

inosine-5'-monophosphate dehydrogenase [...

487

conserved gene; putative drug target function;

Phase 4: April 2009

1ZFJ

56.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01178
(show subtarget assignments)

1

in_pdb
3TSB
3TSD

Yes

BA_0008

30253523

guaB

inosine-5'-monophosphate dehydrogenase

487

Conserved Gene / Pathway

Phase 2: March 2008

3TSB

100%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP05668
(show subtarget assignments)

1

soluble

No

lmo0576

16802619

-

hypothetical protein lmo0576 [Listeria m...

487

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KT7

6%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP04386
(show subtarget assignments)

1

cloned

No

YPO3230

218930257

pepD

aminoacyl-histidine dipeptidase [Yersini...

486

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3MRU

63%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00225
(show subtarget assignments)

1

cloned

No

YPO3069

16123246

-

putative exported protein

486

Virulence

Phase 1: October 2007

3C37

15%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP00173
(show subtarget assignments)

1

cloned

No

YPO2922

16123109

-

putative membrane protein

486

Virulence

Phase 1: October 2007

3K4U

14.4%

Yersinia pestis

Unknown function

General

IDP90586
(show subtarget assignments)

8

cloned

No

YPO2188

16122418

cls

cardiolipin synthetase [Yersinia pestis ...

486

Predicted Essential

Community Requests

Yersinia pestis

IDP05694
(show subtarget assignments)

1

soluble

No

lmo2007

16804046

-

hypothetical protein lmo2007 [Listeria m...

485

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3OMB

21.3%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP90125
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_038

68449112

kelch-like protein [Monkeypox virus]

485

similar to VACV-COP-F3L, MPXV-ZAI96-C9L

Community Requests

1ZGK

13.6%

Monkeypox virus

IDP90781
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1058c

15792385

guaB

inositol-5-monophosphate dehydrogenase [...

485

Predicted Essential

Community Requests

3TSB

61.6%

Campylobacter jejuni

IDP04577
(show subtarget assignments)

1

cloned

No

BAS0087

49183121

glutamyl-tRNA synthetase [Bacillus anthr...

485

Proposed to be essential proteins

Phase 4: April 2009

2O5R

44.4%

Bacillus anthracis

IDP05769
(show subtarget assignments)

1

cloned

No

SACOL0574

57651404

gltX

glutamyl-tRNA synthetase [Staphylococcus...

484

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2O5R

43.2%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP04183
(show subtarget assignments)

1

expressed

No

VCA0257

15601025

sensor histidine kinase [Vibrio cholerae...

484

drug target; putative drug target function;

Phase 4: April 2009

Vibrio cholerae

Regulatory functions

Other

IDP02394
(show subtarget assignments)

1

cloned

No

YPO1633

16121901

phoQ

sensor protein PhoQ [Yersinia pestis CO9...

484

Conserved; CD; Drug target functions

Phase 3: June 2008

1ID0

20.9%

Yersinia pestis

Regulatory functions

Other

IDP05067
(show subtarget assignments)

1

cloned

No

CD2664

126700278

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

484

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2WTZ

36.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04376
(show subtarget assignments)

1

crystallized

No

CPF_2558

110800169

guaB

inositol-5-monophosphate dehydrogenase [...

484

conserved gene; putative drug target function;

Phase 4: April 2009

3TSB

67.4%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP91035
(show subtarget assignments)

8

selected

No

SDY_P070

82524476

ospC2

OspC2 [Shigella dysenteriae Sd197]

484

virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...

Community Requests

Shigella dysenteriae

IDP92094
(show subtarget assignments)

8

selected

No

TGME49_038190

237834427

DNA-directed RNA polymerase II, putative...

484

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1I3Q

20.7%

Toxoplasma gondii

IDP91468
(show subtarget assignments)

8

cloned

No

VPA1370

28901226

hypothetical protein VPA1370 [Vibrio par...

484

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3RYL

49.4%

Vibrio parahaemolyticus

IDP91036
(show subtarget assignments)

8

selected

No

SDY_P151

82524557

ospC3

OspC3 [Shigella dysenteriae Sd197]

484

virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...

Community Requests

Shigella dysenteriae

IDP04430
(show subtarget assignments)

1

purified

No

GBAA4921

47530215

sensor histidine kinase [Bacillus anthra...

484

putative drug target function;

Phase 4: April 2009

2C2A

16.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP01664
(show subtarget assignments)

1

purified

No

Cj0064c

15791456

flhF

flagellar biosynthesis regulator FlhF [C...

484

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1ZU4

17.4%

Campylobacter jejuni

Cell envelope

Surface structures

IDP04014
(show subtarget assignments)

1

purified

No

YPO3173

115348814

thiI

thiamine biosynthesis protein [Yersinia ...

483

conserved gene; putative drug target function;

Phase 4: April 2009

2C5S

23.6%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP90216
(show subtarget assignments)

8

expressed

No

MYXV_gp008

9633799

m005L

m005L, m5, M-T5

483

ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.

Community Requests

1N0R

8.5%

Myxoma virus

host range factor, host defense modulator

0

IDP04343
(show subtarget assignments)

1

expressed

No

YPO2916

218929972

two-component system sensor kinase [Yers...

483

putative drug target function;

Phase 4: April 2009

3A0R

13.5%

Yersinia pestis

Regulatory functions

Other

IDP00184
(show subtarget assignments)

1

cloned

No

YPO0624

16120950

-

putative membrane protein

483

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP92095
(show subtarget assignments)

8

selected

No

TGME49_046920

237835543

glutathione reductase, putative [Toxopla...

483

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1GER

46.2%

Toxoplasma gondii

IDP04329
(show subtarget assignments)

1

expressed

No

CPF_1466

110801108

putative lipoprotein [Clostridium perfri...

483

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04525
(show subtarget assignments)

1

cloned

No

STM1556_1_483

16764900

putative Na+/H+ antiporter [Salmonella t...

483

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP01168
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0084

47566748

capsule synthesis trans-acting positive ...

483

Virulence Associated Factor

Phase 2: March 2008

3SQN

8.5%

Bacillus anthracis

IDP04378
(show subtarget assignments)

1

cloned

No

CPF_2335

110799804

extracellular solute-binding protein [Cl...

482

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP01015
(show subtarget assignments)

0

work_stopped

No

STM2791

16766102

gabD

succinate-semialdehyde dehydrogenase I

482

Conserved Gene / Pathway

Phase 2: March 2008

3JZ4

90%

Salmonella enterica

Central intermediary metabolism

Other

IDP00535
(show subtarget assignments)

1

purified

No

YPO3506

16123652

dacB

D-alanyl-D-alanine carboxypeptidase/endo...

482

Drug Target Function

Phase 2: March 2008

2EX2

77.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04012
(show subtarget assignments)

1

cloned

No

CPF_2355

110800506

virJ

sensor histidine kinase [Clostridium per...

482

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

15.4%

Clostridium perfringens

Cellular processes

Pathogenesis

IDP90426
(show subtarget assignments)

8

cloned

No

CT_863

3329337

hypothetical protein [Chlamydia trachoma...

482

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP02632
(show subtarget assignments)

1

cloned

No

lmo0582

16802625

iap

P60 extracellular protein, invasion asso...

482

Known virulence-Invasion; Possible Vaccine Candidate; Known Essential Genes; PMI...

Phase 3: June 2008

3H41

14.1%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP01167
(show subtarget assignments)

1

expressed

No

GBAA_pXO2_0060

47566729

capsule synthesis trans-acting positive ...

482

Virulence Associated Factor

Phase 2: March 2008

3SQN

22%

Bacillus anthracis

IDP00557
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3382

16123531

gsrA

serine endoprotease

481

Virulence Associated Factor

Phase 2: March 2008

2ZLE

71.9%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP91986
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100006694

298255280

capsule biosynthesis integral membrane r...

481

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2XXP

74.6%

Streptococcus pneumoniae

IDP90595
(show subtarget assignments)

8

expressed

No

YPO2298

16122522

phoA

alkaline phosphatase [Yersinia pestis CO...

481

Predicted Essential

Community Requests

1B8J

70.7%

Yersinia pestis

IDP01253
(show subtarget assignments)

1

cloned

No

BA_2575

30257197

penicillin-binding protein, putative

481

Drug Target Function

Phase 2: March 2008

2QMI

20%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90188
(show subtarget assignments)

8

cloned

No

AAM13496.1

20153035

CPXV050 CDS

CPXV050 protein

480

kelch-like protein

Community Requests

3II7

12.3%

Cowpox virus

conserved hypothetical proteins

0

IDP91823
(show subtarget assignments)

8

soluble

No

b1854

1788160

pykA

pyruvate kinase II [Escherichia coli str...

480

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

2E28

40.6%

Escherichia coli

IDP04305
(show subtarget assignments)

1

cloned

No

CPF_2386

110798631

ribonuclease [Clostridium perfringens AT...

480

conserved gene; putative drug target function;

Phase 4: April 2009

2BX2

27.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04433
(show subtarget assignments)

1

cloned

No

GBAA5276

47530584

sensor histidine kinase [Bacillus anthra...

480

putative drug target function;

Phase 4: April 2009

3A0R

13.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP91676
(show subtarget assignments)

8

selected

No

DNJA3_HUMAN

0

480

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

3LZ8

19.6%

Homo sapiens

IDP92099
(show subtarget assignments)

8

selected

No

TGME49_105460

237842063

methionine aminopeptidase, type II, puta...

480

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1B6A

44.8%

Toxoplasma gondii

IDP00420
(show subtarget assignments)

1

purified

No

YPO1207

16121498

katA

catalase

480

Virulence Associated Factor

Phase 2: March 2008

1M85

84.2%

Yersinia pestis

Cellular processes

Detoxification

IDP05635
(show subtarget assignments)

1

cloned

No

CD2193

126699809

cell surface protein [Clostridium diffic...

480

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP91190
(show subtarget assignments)

1

in_crystallization_trials

No

EF_A0061

29345308

6'-aminoglycoside N-acetyltransferase [E...

479

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3R6Z

20%

Enterococcus faecalis

IDP01039
(show subtarget assignments)

1

expressed

No

STM2934

16766240

cysN

sulfate adenylyltransferase subunit 1

479

Conserved Gene / Pathway

Phase 2: March 2008

1ZUN

52.4%

Salmonella enterica

Central intermediary metabolism

Sulfur metabolism

IDP02653
(show subtarget assignments)

1

in_crystallization_trials

No

STM2840

16766146

anaerobic nitric oxide reductase flavoru...

479

Conserved; Drug target functions

Phase 3: June 2008

1YCF

33.8%

Salmonella enterica

Energy metabolism

Electron transport

IDP02398
(show subtarget assignments)

1

in_pdb
3PEI

Yes

FTT1318c

56708375

pepA

cytosol aminopeptidase [Francisella tula...

479

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3PEI

100%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91171
(show subtarget assignments)

8

expressed

No

CT_370

9087121

RecName: Full=Shikimate biosynthesis pro...

478

potential drug target / Shikimate pathway enzyme

Community Requests

2EGG

18.2%

Chlamydia trachomatis

IDP02192
(show subtarget assignments)

1

soluble

No

YPO0348

16120683

aspA

aspartate ammonia-lyase [Yersinia pestis...

478

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1JSW

89.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP02363
(show subtarget assignments)

1

purified

No

FTT1366c

56708419

pyk

pyruvate kinase [Francisella tularensis ...

478

Conserved; Drug target functions

Phase 3: June 2008

1E0U

39.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP04454
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1254

218928409

bglA

6-phospho-beta-glucosidase [Yersinia pes...

478

drug target; putative drug target function;

Phase 4: April 2009

2XHY

77.8%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP04213
(show subtarget assignments)

1

cloned

No

STM1003_1_478

16764363

putative transcriptional regulator [Salm...

478

Salmonella essential protein

Phase 4: April 2009

Salmonella enterica

IDP05109
(show subtarget assignments)

1

cloned

No

CD1987

126699595

cell surface protein [Clostridium diffic...

478

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP04247
(show subtarget assignments)

1

expressed

No

CPF_1402

110798994

sensor histidine kinase [Clostridium per...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

16.3%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP04630
(show subtarget assignments)

1

cloned

No

CBU_1228

29654531

qseC

sensor protein qseC [Coxiella burnetii R...

478

conserved gene; putative drug target function;

Phase 4: April 2009

3JZ3

19%

Coxiella burnetii

Regulatory functions

Other

IDP05700
(show subtarget assignments)

1

soluble

No

lmo2467

16804505

-

hypothetical protein lmo2467 [Listeria m...

478

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2BEM

18.2%

Listeria monocytogenes

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP91185
(show subtarget assignments)

8

cloned

No

AAC46367

2352978

477

virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...

Community Requests

1NY5

31.9%

Vibrio cholerae

IDP91027
(show subtarget assignments)

8

expressed

No

y3600

22127474

uxaC

uronate isomerase [Yersinia pestis KIM]

477

other biological interest / -

Community Requests

3IAC

64.4%

Yersinia pestis

IDP04240
(show subtarget assignments)

1

cloned

No

CPF_1077

110800997

extracellular solute-binding protein [Cl...

477

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W7Y

15.3%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP02041
(show subtarget assignments)

1

in_crystallization_trials

No

STM3051

16766352

bglA

6-phospho-beta-glucosidase A [Salmonella...

477

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2XHY

95.4%

Salmonella enterica

Energy metabolism

Other

IDP02640
(show subtarget assignments)

1

purified

No

GBAA0609

47525887

aspA

aspartate ammonia-lyase [Bacillus anthra...

477

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1J3U

70.6%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP92093
(show subtarget assignments)

8

selected

No

TGME49_025050

237833761

adenosylhomocysteinase, putative [Toxopl...

477

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3OND

68.6%

Toxoplasma gondii

IDP01736
(show subtarget assignments)

1

expressed

No

GBAA5503

47530821

sensor histidine kinase [Bacillus anthra...

476

Conserved; Drug target functions

Phase 3: June 2008

2C2A

15.5%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP00574
(show subtarget assignments)

1

cloned

No

YPO0531

16120860

leuC

isopropylmalate isomerase large subunit ...

476

Virulence Associated Factor

Phase 2: March 2008

1ACO

25%

Yersinia pestis

Amino acid biosynthesis

Pyruvate family

IDP02485
(show subtarget assignments)

1

cloned

No

FTT1539c

56708571

hypothetical protein FTT1539c [Francisel...

476

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP00558
(show subtarget assignments)

1

purified

No

YPO0654

16120979

rfaE

bifunctional heptose 7-phosphate kinase/...

476

Conserved Gene / Pathway

Phase 2: March 2008

2FV7

16.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04189
(show subtarget assignments)

1

expressed

No

CPF_0225

110799110

sensor histidine kinase [Clostridium per...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

13%

Clostridium perfringens

Regulatory functions

Protein interactions

IDP90096
(show subtarget assignments)

8

expressed

No

ZZZ_0012

476

This protein is a component of a type VI secretion system of enteroaggregative E...

Community Requests

Escherichia coli

IDP00553
(show subtarget assignments)

1

expressed

No

YPO3939

16124067

glgA

glycogen synthase

476

Drug Target Function

Phase 2: March 2008

2QZS

71.4%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP91426
(show subtarget assignments)

8

cloned

No

VV1_0536

27363999

Na+/alanine symporter [Vibrio vulnificus...

476

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91408
(show subtarget assignments)

8

soluble

No

VV1_0725

27364179

cysN

sulfate adenylyltransferase subunit 1 [V...

476

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1ZUN

54.8%

Vibrio vulnificus

IDP05187
(show subtarget assignments)

1

cloned

No

CD0199

126697770

putative membrane-associated nucleotidas...

476

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GVE

19.5%

Clostridium difficile

Cell envelope: Other