Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01449 (show subtarget assignments)	1	purified	No	VC2248	15642246		UDP-N-acetylglucosamine acyltransferase ...	262	Drug Target Function	Phase 2: March 2008	1LXA	68.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01450 (show subtarget assignments)	1	in_crystallization_trials	No	VC2269	15642267		3,4-dihydroxy-2-butanone 4-phosphate syn...	369	Drug Target Function	Phase 2: March 2008	1G57	30.1%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01451 (show subtarget assignments)	1	purified	No	VC2305	15642303		outer membrane protein OmpK	296	Conserved Gene / Pathway	Phase 2: March 2008	1TLW	26%	Vibrio cholerae	Transport and binding proteins	Nucleosides, purines and pyrimidines

IDP01452 (show subtarget assignments)	1	soluble	No	VC2400	15642397	murC	UDP-N-acetylmuramate--L-alanine ligase	506	Conserved Gene / Pathway	Phase 2: March 2008	2F00	69.4%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453 (show subtarget assignments)	1	cloned	No	VC2401	15642398	murG	N-acetylglucosaminyl transferase	354	Conserved Gene / Pathway	Phase 2: March 2008	1F0K	63.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01454 (show subtarget assignments)	1	purified	No	VC2403	161581989	murD	UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...	444	Conserved Gene / Pathway	Phase 2: March 2008	1E0D	51.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455 (show subtarget assignments)	1	purified	No	VC2405	15642402		UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	453	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	52.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456 (show subtarget assignments)	1	purified	No	VC2406	15642403	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	512	Conserved Gene / Pathway	Phase 2: March 2008	1E8C	50.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01457 (show subtarget assignments)	1	cloned	No	VC2407	15642404		penicillin-binding protein 3	580	Drug Target Function	Phase 2: March 2008	3OC2	41.6%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01458 (show subtarget assignments)	1	soluble	No	VC2418	15642415		thiol:disulfide interchange protein DsbC...	250	Drug Target Function	Phase 2: March 2008	1JZD	38.4%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01459 (show subtarget assignments)	1	soluble	No	VC2420	161581987		flavodoxin	172	Conserved Gene / Pathway	Phase 2: March 2008	1AG9	45.3%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01460 (show subtarget assignments)	1	cloned	No	VC2423	15642420		fimbrial protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1OQW	37.1%	Vibrio cholerae	Cell envelope	Surface structures

IDP01461 (show subtarget assignments)	1	in_pdb 3H88	No	VC2457	15642453	acpS	4'-phosphopantetheinyl transferase	126	Drug Target Function	Phase 2: March 2008	3H88	100%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01462 (show subtarget assignments)	1	soluble	No	VC2462	15642458		signal peptidase I	298	Drug Target Function	Phase 2: March 2008	1B12	46.6%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP01463 (show subtarget assignments)	1	in_crystallization_trials	No	VC2514	15642510		UDP-N-acetylglucosamine 1-carboxyvinyltr...	419	Drug Target Function	Phase 2: March 2008	3VCY	85.9%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01464 (show subtarget assignments)	1	soluble	No	VC2520	15642516		ABC transporter, ATP-binding protein	267	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	34.5%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01465 (show subtarget assignments)	1	purified	No	VC2528	15642523		ABC transporter, ATP-binding protein	241	Conserved Gene / Pathway	Phase 2: March 2008	1JI0	33.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01466 (show subtarget assignments)	1	in_crystallization_trials	No	VC2542	15642537		UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	451	Conserved Gene / Pathway	Phase 2: March 2008	3HN7	51%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01467 (show subtarget assignments)	1	purified	No	VC2549	15642544		methionine sulfoxide reductase A	212	Conserved Gene / Pathway	Phase 2: March 2008	2GT3	56.1%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP01468 (show subtarget assignments)	1	purified	No	VC2553	15642548		ABC transporter, ATP-binding protein, au...	238	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	32.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01469 (show subtarget assignments)	1	purified	No	VC2568	15642563		peptidyl-prolyl cis-trans isomerase, FKB...	209	Conserved Gene / Pathway	Phase 2: March 2008	1FD9	40.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01470 (show subtarget assignments)	1	purified	No	VC2608	15642603		ABC transporter, ATP-binding protein	664	Conserved Gene / Pathway	Phase 2: March 2008	2IW3	23.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01471 (show subtarget assignments)	1	purified	No	VC2613	15642608		phosphoribulokinase	289	Conserved Gene / Pathway	Phase 2: March 2008	1A7J	51.6%	Vibrio cholerae	Energy metabolism	Sugars

IDP01472 (show subtarget assignments)	1	cloned	No	VC2631	15642626		fimbrial assembly protein PilP, putative...	172	Conserved Gene / Pathway	Phase 2: March 2008	2LC4	16.3%	Vibrio cholerae	Cell envelope	Surface structures

IDP01473 (show subtarget assignments)	1	soluble	No	VC2653	15642648		preprotein translocase subunit SecB	154	Conserved Gene / Pathway	Phase 2: March 2008	1QYN	66.2%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP01474 (show subtarget assignments)	1	expressed	No	VC2657	15642652		fumarate reductase iron-sulfur subunit	252	Conserved Gene / Pathway	Phase 2: March 2008	1KF6	69%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP01475 (show subtarget assignments)	1	in_crystallization_trials	No	VC2675	15642670		ATP-dependent protease peptidase subunit...	185	Conserved Gene / Pathway	Phase 2: March 2008	1E94	78.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01476 (show subtarget assignments)	1	soluble	No	VC2694	15642689		superoxide dismutase, Mn	222	Conserved Gene / Pathway	Phase 2: March 2008	2RCV	48.2%	Vibrio cholerae	Cellular processes	Detoxification

IDP01477 (show subtarget assignments)	1	purified	No	VC2762	15642755	glmU	bifunctional N-acetylglucosamine-1-phosp...	453	Drug Target Function	Phase 2: March 2008	1HV9	67.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01478 (show subtarget assignments)	1	purified	No	VC2772	15642765		ParB family protein	293	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	33.8%	Vibrio cholerae	Cellular processes	Cell division

IDP01479 (show subtarget assignments)	1	expressed	No	VCA0064	15600835		TonB system receptor, putative	713	Conserved Gene / Pathway	Phase 2: March 2008	1NQF	22.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01480 (show subtarget assignments)	1	cloned	No	VCA0116	15600887		clpB protein	869	Drug Target Function	Phase 2: March 2008	1QVR	36.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01481 (show subtarget assignments)	1	expressed	No	VCA0130	15600901		D-ribose transporter subunit RbsB	294	Conserved Gene / Pathway	Phase 2: March 2008	1DBP	65.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01482 (show subtarget assignments)	1	in_pdb 3QU1	No	VCA0150	15600920	def	peptide deformylase	168	Conserved Gene / Pathway	Phase 2: March 2008	3QU1	100%	Vibrio cholerae	Protein fate	Protein modification and repair

IDP01483 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0180	15600950		peptidase T	410	Drug Target Function	Phase 2: March 2008	1VIX	57.6%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01484 (show subtarget assignments)	1	in_pdb 4EH1	No	VCA0183	15600953		nitric oxide dioxygenase	394	Conserved Gene / Pathway	Phase 2: March 2008	4EH1	61.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01485 (show subtarget assignments)	1	soluble	No	VCA0220	15600989		hemolysin secretion protein HylB	548	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	16.4%	Vibrio cholerae	Transport and binding proteins	Other

IDP01486 (show subtarget assignments)	1	in_pdb 3IEB 3JR2	No	VCA0242	15601010	ulaD	3-keto-L-gulonate-6-phosphate decarboxyl...	215	Conserved Gene / Pathway	Phase 2: March 2008	3IEB	100%	Vibrio cholerae	Energy metabolism	Sugars

IDP01487 (show subtarget assignments)	1	soluble	No	VCA0270	15601038		D-alanyl-D-alanine carboxypeptidase	389	Drug Target Function	Phase 2: March 2008	1NZO	44.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01488 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0572	15601331	ddl	D-alanyl-alanine synthetase A	334	Conserved Gene / Pathway	Phase 2: March 2008	2FB9	34.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01489 (show subtarget assignments)	1	cloned	No	VCA0591	15601350		peptide ABC transporter, periplasmic pep...	611	Conserved Gene / Pathway	Phase 2: March 2008	1ZTY	21.8%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01491 (show subtarget assignments)	1	soluble	No	VCA0603	15601361		ABC transporter, periplasmic substrate-b...	339	Conserved Gene / Pathway	Phase 2: March 2008	1Y4T	18.3%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01492 (show subtarget assignments)	1	purified	No	VCA0702	15601458		iron-containing alcohol dehydrogenase	382	Conserved Gene / Pathway	Phase 2: March 2008	1OJ7	50.8%	Vibrio cholerae	Energy metabolism	Fermentation

IDP01493 (show subtarget assignments)	1	diffraction	No	VCA0751	161582040		3-oxoacyl-(acyl carrier protein) synthas...	362	Drug Target Function	Phase 2: March 2008	2EBD	40.9%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01494 (show subtarget assignments)	1	purified	No	VCA0780	15601535		UDP-glucose 6-dehydrogenase	388	Conserved Gene / Pathway	Phase 2: March 2008	3PHL	71.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01495 (show subtarget assignments)	1	cloned	No	VCA0803	15601558		serine protease, putative	330	Drug Target Function	Phase 2: March 2008	1BRU	24.2%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01496 (show subtarget assignments)	1	soluble	No	VCA0813	15601568		aminopeptidase	501	Drug Target Function	Phase 2: March 2008	1RTQ	43.9%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01497 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0820	15601575	groEL	chaperonin GroEL	530	Conserved Gene / Pathway	Phase 2: March 2008	1AON	74.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01498 (show subtarget assignments)	1	expressed	No	VCA0862	15601617		long-chain fatty acid transport protein ...	412	Conserved Gene / Pathway	Phase 2: March 2008	1T16	39.2%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01499 (show subtarget assignments)	1	cloned	No	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01500 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0945	15601698	malE	maltose ABC transporter periplasmic prot...	406	Conserved Gene / Pathway	Phase 2: March 2008	3JYR	65%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01501 (show subtarget assignments)	1	expressed	No	VCA0946	15601699		maltose/maltodextrin transporter ATP-bin...	373	Conserved Gene / Pathway	Phase 2: March 2008	1Q12	67.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01502 (show subtarget assignments)	1	expressed	No	VCA0977	15601730		ABC transporter, ATP-binding protein	539	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	23.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01504 (show subtarget assignments)	1	expressed	No	VCA1028	15601781	lamB	maltoporin	416	Conserved Gene / Pathway	Phase 2: March 2008	1AF6	32.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01505 (show subtarget assignments)	1	expressed	No	VCA1037	15601788		amino acid ABC transporter, ATP-binding ...	239	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	52.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01506 (show subtarget assignments)	1	in_crystallization_trials	No	VCA1113	15601861		spermidine/putrescine ABC transporter, p...	343	Conserved Gene / Pathway	Phase 2: March 2008	1POT	37.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01507 (show subtarget assignments)	1	in_crystallization_trials	No	VC2045	15642047		superoxide dismutase, Fe	194	Conserved Gene / Pathway	Phase 2: March 2008	2W7W	86.6%	Vibrio cholerae	Cellular processes	Detoxification

IDP01508 (show subtarget assignments)	1	expressed	No	VCA0127	15600898		ribose ABC transporter protein	156	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	48.1%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01509 (show subtarget assignments)	1	expressed	No	VC0549	15640571		oxaloacetate decarboxylase subunit gamma...	117	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01510 (show subtarget assignments)	1	in_crystallization_trials	No	VC0731	15640750		antioxidant, AhpC/Tsa family	207	Conserved Gene / Pathway	Phase 2: March 2008	1ZOF	55.1%	Vibrio cholerae	Cellular processes	Detoxification

IDP01511 (show subtarget assignments)	1	expressed	No	VC0794	15640812		hypothetical protein VC0794	139	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01512 (show subtarget assignments)	1	soluble	No	VC1173	15641186		anthranilate synthase component II	203	Drug Target Function	Phase 2: March 2008	1I1Q	57.1%	Vibrio cholerae	Amino acid biosynthesis	Aromatic amino acid family

IDP01513 (show subtarget assignments)	1	purified	No	VC1312	161582006	alr	alanine racemase	407	Conserved Gene / Pathway	Phase 2: March 2008	4ECL	26%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01514 (show subtarget assignments)	1	purified	No	VCA0518	15601278		fructose-specific PTS IIA/HPr components...	400	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	11.5%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01515 (show subtarget assignments)	1	in_pdb 3ECT 3NZ2	Yes	VCA0836	15601591		hexapeptide-repeat containing-acetyltran...	192	Drug Target Function	Phase 2: March 2008	3ECT	100%	Vibrio cholerae	Central intermediary metabolism	Other

IDP01516 (show subtarget assignments)	1	crystallized	No	VC0576	15640598	sspA	stringent starvation protein A	211	Conserved Gene / Pathway	Phase 2: March 2008	1YY7	73.9%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP01517 (show subtarget assignments)	1	expressed	No	VC1254	15641267		iron-sulfur cluster-binding protein, put...	92	Conserved Gene / Pathway	Phase 2: March 2008	1AWD	26.1%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01518 (show subtarget assignments)	1	purified	No	VC1512	15641521		formate dehydrogenase, iron-sulfur subun...	202	Conserved Gene / Pathway	Phase 2: March 2008	1KQF	29%	Vibrio cholerae	Energy metabolism	Anaerobic

IDP01519 (show subtarget assignments)	1	purified	No	VC2149	15642148		hypothetical protein VC2149	95	Drug Target Function	Phase 2: March 2008	3KE2	43.2%	Vibrio cholerae

IDP01520 (show subtarget assignments)	1	expressed	No	VCA0782	15601537		ABC transporter, ATP-binding protein	225	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	46.7%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01530 (show subtarget assignments)	1	in_pdb 3EFV 3ETF	No	STM1524	16764869	yneI	putative succinate-semialdehyde dehydrog...	462	It is an essential gene in Salmonella which is important in energy metabolism.	Phase 3: June 2008	3EFV	100%	Salmonella enterica

IDP01531 (show subtarget assignments)	1	in_pdb 3EFB	No	SF4094	56384059	sorC	probable sor-operon regulator [Shigella ...	315	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 3: June 2008	2W48	86.3%	Shigella flexneri

IDP01540 (show subtarget assignments)	1	in_pdb 3EC6	No	GBAA0418	47525694		general stress protein 26 [Bacillus anth...	138	CONSERVED	Phase 3: June 2008	3EC6	100%	Bacillus anthracis

IDP01601 (show subtarget assignments)	1	expressed	No	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01602 (show subtarget assignments)	1	expressed	No	YPO2288	16122512	amn	AMP nucleosidase [Yersinia pestis CO92]	546	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	1T8R	63.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01603 (show subtarget assignments)	1	cloned	No	STM1971	16765309	fliH	flagellar assembly protein H [Salmonella...	235	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP01604 (show subtarget assignments)	1	crystallized	No	CBU_0704	29541308	rfbI	lipopolysaccharide/O-antigen ABC transpo...	258	Conserved; Drug target functions	Phase 3: June 2008	3QF4	25.6%	Coxiella burnetii	Transport and binding proteins	Other

IDP01605 (show subtarget assignments)	1	soluble	No	GBAA4560	47529856		hypothetical protein GBAA4560 [Bacillus ...	97	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	1RQ8	67%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP01606 (show subtarget assignments)	1	cloned	No	GBAA4968	47530266	gdH	glucose-1-dehydrogenase [Bacillus anthra...	261	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1GEE	87.7%	Bacillus anthracis	Energy metabolism	Other

IDP01607 (show subtarget assignments)	1	cloned	No	FTT1608	56708628		ABC transporter, ATP-binding protein [Fr...	267	Conserved; Drug target functions	Phase 3: June 2008	3DHW	30%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01608 (show subtarget assignments)	1	cloned	No	CBU_1504	29542063	lepB-2	signal peptidase I [Coxiella burnetii RS...	256	Conserved; Drug target functions	Phase 3: June 2008	1B12	36.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP01609 (show subtarget assignments)	1	crystallized	No	FTT1512c	56708550	dnaJ1	heat shock protein, hsp40 [Francisella t...	308	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	34.2%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01610 (show subtarget assignments)	1	in_pdb 3I1I	No	GBAA4983	47778350		homoserine O-acetyltransferase [Bacillus...	374	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3I1I	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP01611 (show subtarget assignments)	1	in_pdb 3TAU	Yes	lmo1827	16803867	gmk	hypothetical protein lmo1827 [Listeria m...	205	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	3TAU	100%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP01612 (show subtarget assignments)	1	cloned	No	FTT1538c	56708570		hypothetical protein FTT1538c [Francisel...	327	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01613 (show subtarget assignments)	1	in_crystallization_trials	No	STM1927	16765269	yecG	universal stress protein UspC [Salmonell...	142	Conserved; Drug target functions	Phase 3: June 2008	1JMV	35.2%	Salmonella enterica	Cellular processes	Adaptations to atypical conditions

IDP01614 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2581	16122794		putative sugar-binding periplasmic prote...	309	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	29.5%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01615 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0643	29541244	ribD	riboflavin biosynthesis protein RibD [Co...	354	Conserved; Drug target functions	Phase 3: June 2008	2HXV	35.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01616 (show subtarget assignments)	1	in_pdb 3EG7	No	VC_A0947	9658384		spermidine n1-acetyltransferase [Vibrio ...	173	CONSERVED	Phase 3: June 2008	3EG7	100%	Vibrio cholerae	N/A	N/A

IDP01619 (show subtarget assignments)	1	expressed	No	CBU_1871	29542425	pabA	para-aminobenzoate synthase glutamine am...	201	Conserved; Drug target functions	Phase 3: June 2008	1QDL	44.3%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01620 (show subtarget assignments)	1	cloned	No	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP01621 (show subtarget assignments)	1	cloned	No	STM1984	16765321	yodD	putative cytoplasmic protein [Salmonella...	75	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01622 (show subtarget assignments)	1	cloned	No	STM4396	16767642	ytfB	putative cell envelope opacity-associate...	211	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP01623 (show subtarget assignments)	1	cloned	No	GBAA5019	47530321	pckA	phosphoenolpyruvate carboxykinase [Bacil...	528	Conserved; Essential; Drug target functions	Phase 3: June 2008	1J3B	52.8%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01624 (show subtarget assignments)	1	expressed	No	CBU_1879	29542436		polypeptide deformylase, putative [Coxie...	209	Conserved; Drug target functions	Phase 3: June 2008	1LM6	29.2%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP01625 (show subtarget assignments)	1	expressed	No	FTT1761	56708756		hypothetical protein FTT1761 [Francisell...	239	Drug Target	Phase 3: June 2008			Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP01626 (show subtarget assignments)	1	cloned	No	GBAA5017	47530320	metK	S-adenosylmethionine synthetase [Bacillu...	399	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FUG	62.4%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01627 (show subtarget assignments)	1	cloned	No	GBAA0530	50196914		glutamate synthase, large subunit, putat...	1478	Conserved; Drug target functions	Phase 3: June 2008	1EA0	29.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP01449
(show subtarget assignments)

1

purified

No

VC2248

15642246

UDP-N-acetylglucosamine acyltransferase ...

262

Drug Target Function

Phase 2: March 2008

1LXA

68.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01450
(show subtarget assignments)

1

in_crystallization_trials

No

VC2269

15642267

3,4-dihydroxy-2-butanone 4-phosphate syn...

369

Drug Target Function

Phase 2: March 2008

1G57

30.1%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01451
(show subtarget assignments)

1

purified

No

VC2305

15642303

outer membrane protein OmpK

296

Conserved Gene / Pathway

Phase 2: March 2008

1TLW

26%

Vibrio cholerae

Transport and binding proteins

Nucleosides, purines and pyrimidines

IDP01452
(show subtarget assignments)

1

soluble

No

VC2400

15642397

murC

UDP-N-acetylmuramate--L-alanine ligase

506

Conserved Gene / Pathway

Phase 2: March 2008

2F00

69.4%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01453
(show subtarget assignments)

1

cloned

No

VC2401

15642398

murG

N-acetylglucosaminyl transferase

354

Conserved Gene / Pathway

Phase 2: March 2008

1F0K

63.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01454
(show subtarget assignments)

1

purified

No

VC2403

161581989

murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...

444

Conserved Gene / Pathway

Phase 2: March 2008

1E0D

51.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455
(show subtarget assignments)

1

purified

No

VC2405

15642402

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

453

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

52.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01456
(show subtarget assignments)

1

purified

No

VC2406

15642403

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

512

Conserved Gene / Pathway

Phase 2: March 2008

1E8C

50.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01457
(show subtarget assignments)

1

cloned

No

VC2407

15642404

penicillin-binding protein 3

580

Drug Target Function

Phase 2: March 2008

3OC2

41.6%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01458
(show subtarget assignments)

1

soluble

No

VC2418

15642415

thiol:disulfide interchange protein DsbC...

250

Drug Target Function

Phase 2: March 2008

1JZD

38.4%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01459
(show subtarget assignments)

1

soluble

No

VC2420

161581987

flavodoxin

172

Conserved Gene / Pathway

Phase 2: March 2008

1AG9

45.3%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01460
(show subtarget assignments)

1

cloned

No

VC2423

15642420

fimbrial protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1OQW

37.1%

Vibrio cholerae

Cell envelope

Surface structures

IDP01461
(show subtarget assignments)

1

in_pdb
3H88

No

VC2457

15642453

acpS

4'-phosphopantetheinyl transferase

126

Drug Target Function

Phase 2: March 2008

3H88

100%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01462
(show subtarget assignments)

1

soluble

No

VC2462

15642458

signal peptidase I

298

Drug Target Function

Phase 2: March 2008

1B12

46.6%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP01463
(show subtarget assignments)

1

in_crystallization_trials

No

VC2514

15642510

UDP-N-acetylglucosamine 1-carboxyvinyltr...

419

Drug Target Function

Phase 2: March 2008

3VCY

85.9%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01464
(show subtarget assignments)

1

soluble

No

VC2520

15642516

ABC transporter, ATP-binding protein

267

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

34.5%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01465
(show subtarget assignments)

1

purified

No

VC2528

15642523

ABC transporter, ATP-binding protein

241

Conserved Gene / Pathway

Phase 2: March 2008

1JI0

33.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01466
(show subtarget assignments)

1

in_crystallization_trials

No

VC2542

15642537

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

451

Conserved Gene / Pathway

Phase 2: March 2008

3HN7

51%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01467
(show subtarget assignments)

1

purified

No

VC2549

15642544

methionine sulfoxide reductase A

212

Conserved Gene / Pathway

Phase 2: March 2008

2GT3

56.1%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP01468
(show subtarget assignments)

1

purified

No

VC2553

15642548

ABC transporter, ATP-binding protein, au...

238

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

32.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01469
(show subtarget assignments)

1

purified

No

VC2568

15642563

peptidyl-prolyl cis-trans isomerase, FKB...

209

Conserved Gene / Pathway

Phase 2: March 2008

1FD9

40.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01470
(show subtarget assignments)

1

purified

No

VC2608

15642603

ABC transporter, ATP-binding protein

664

Conserved Gene / Pathway

Phase 2: March 2008

2IW3

23.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01471
(show subtarget assignments)

1

purified

No

VC2613

15642608

phosphoribulokinase

289

Conserved Gene / Pathway

Phase 2: March 2008

1A7J

51.6%

Vibrio cholerae

Energy metabolism

Sugars

IDP01472
(show subtarget assignments)

1

cloned

No

VC2631

15642626

fimbrial assembly protein PilP, putative...

172

Conserved Gene / Pathway

Phase 2: March 2008

2LC4

16.3%

Vibrio cholerae

Cell envelope

Surface structures

IDP01473
(show subtarget assignments)

1

soluble

No

VC2653

15642648

preprotein translocase subunit SecB

154

Conserved Gene / Pathway

Phase 2: March 2008

1QYN

66.2%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP01474
(show subtarget assignments)

1

expressed

No

VC2657

15642652

fumarate reductase iron-sulfur subunit

252

Conserved Gene / Pathway

Phase 2: March 2008

1KF6

69%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP01475
(show subtarget assignments)

1

in_crystallization_trials

No

VC2675

15642670

ATP-dependent protease peptidase subunit...

185

Conserved Gene / Pathway

Phase 2: March 2008

1E94

78.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01476
(show subtarget assignments)

1

soluble

No

VC2694

15642689

superoxide dismutase, Mn

222

Conserved Gene / Pathway

Phase 2: March 2008

2RCV

48.2%

Vibrio cholerae

Cellular processes

Detoxification

IDP01477
(show subtarget assignments)

1

purified

No

VC2762

15642755

glmU

bifunctional N-acetylglucosamine-1-phosp...

453

Drug Target Function

Phase 2: March 2008

1HV9

67.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01478
(show subtarget assignments)

1

purified

No

VC2772

15642765

ParB family protein

293

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

33.8%

Vibrio cholerae

Cellular processes

Cell division

IDP01479
(show subtarget assignments)

1

expressed

No

VCA0064

15600835

TonB system receptor, putative

713

Conserved Gene / Pathway

Phase 2: March 2008

1NQF

22.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01480
(show subtarget assignments)

1

cloned

No

VCA0116

15600887

clpB protein

869

Drug Target Function

Phase 2: March 2008

1QVR

36.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01481
(show subtarget assignments)

1

expressed

No

VCA0130

15600901

D-ribose transporter subunit RbsB

294

Conserved Gene / Pathway

Phase 2: March 2008

1DBP

65.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01482
(show subtarget assignments)

1

in_pdb
3QU1

No

VCA0150

15600920

def

peptide deformylase

168

Conserved Gene / Pathway

Phase 2: March 2008

3QU1

100%

Vibrio cholerae

Protein fate

Protein modification and repair

IDP01483
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0180

15600950

peptidase T

410

Drug Target Function

Phase 2: March 2008

1VIX

57.6%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01484
(show subtarget assignments)

1

in_pdb
4EH1

No

VCA0183

15600953

nitric oxide dioxygenase

394

Conserved Gene / Pathway

Phase 2: March 2008

4EH1

61.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01485
(show subtarget assignments)

1

soluble

No

VCA0220

15600989

hemolysin secretion protein HylB

548

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

16.4%

Vibrio cholerae

Transport and binding proteins

Other

IDP01486
(show subtarget assignments)

1

in_pdb
3IEB
3JR2

No

VCA0242

15601010

ulaD

3-keto-L-gulonate-6-phosphate decarboxyl...

215

Conserved Gene / Pathway

Phase 2: March 2008

3IEB

100%

Vibrio cholerae

Energy metabolism

Sugars

IDP01487
(show subtarget assignments)

1

soluble

No

VCA0270

15601038

D-alanyl-D-alanine carboxypeptidase

389

Drug Target Function

Phase 2: March 2008

1NZO

44.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01488
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0572

15601331

ddl

D-alanyl-alanine synthetase A

334

Conserved Gene / Pathway

Phase 2: March 2008

2FB9

34.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01489
(show subtarget assignments)

1

cloned

No

VCA0591

15601350

peptide ABC transporter, periplasmic pep...

611

Conserved Gene / Pathway

Phase 2: March 2008

1ZTY

21.8%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01491
(show subtarget assignments)

1

soluble

No

VCA0603

15601361

ABC transporter, periplasmic substrate-b...

339

Conserved Gene / Pathway

Phase 2: March 2008

1Y4T

18.3%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01492
(show subtarget assignments)

1

purified

No

VCA0702

15601458

iron-containing alcohol dehydrogenase

382

Conserved Gene / Pathway

Phase 2: March 2008

1OJ7

50.8%

Vibrio cholerae

Energy metabolism

Fermentation

IDP01493
(show subtarget assignments)

1

diffraction

No

VCA0751

161582040

3-oxoacyl-(acyl carrier protein) synthas...

362

Drug Target Function

Phase 2: March 2008

2EBD

40.9%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01494
(show subtarget assignments)

1

purified

No

VCA0780

15601535

UDP-glucose 6-dehydrogenase

388

Conserved Gene / Pathway

Phase 2: March 2008

3PHL

71.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01495
(show subtarget assignments)

1

cloned

No

VCA0803

15601558

serine protease, putative

330

Drug Target Function

Phase 2: March 2008

1BRU

24.2%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01496
(show subtarget assignments)

1

soluble

No

VCA0813

15601568

aminopeptidase

501

Drug Target Function

Phase 2: March 2008

1RTQ

43.9%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01497
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0820

15601575

groEL

chaperonin GroEL

530

Conserved Gene / Pathway

Phase 2: March 2008

1AON

74.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01498
(show subtarget assignments)

1

expressed

No

VCA0862

15601617

long-chain fatty acid transport protein ...

412

Conserved Gene / Pathway

Phase 2: March 2008

1T16

39.2%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01499
(show subtarget assignments)

1

cloned

No

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01500
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0945

15601698

malE

maltose ABC transporter periplasmic prot...

406

Conserved Gene / Pathway

Phase 2: March 2008

3JYR

65%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01501
(show subtarget assignments)

1

expressed

No

VCA0946

15601699

maltose/maltodextrin transporter ATP-bin...

373

Conserved Gene / Pathway

Phase 2: March 2008

1Q12

67.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01502
(show subtarget assignments)

1

expressed

No

VCA0977

15601730

ABC transporter, ATP-binding protein

539

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

23.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01504
(show subtarget assignments)

1

expressed

No

VCA1028

15601781

lamB

maltoporin

416

Conserved Gene / Pathway

Phase 2: March 2008

1AF6

32.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01505
(show subtarget assignments)

1

expressed

No

VCA1037

15601788

amino acid ABC transporter, ATP-binding ...

239

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

52.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01506
(show subtarget assignments)

1

in_crystallization_trials

No

VCA1113

15601861

spermidine/putrescine ABC transporter, p...

343

Conserved Gene / Pathway

Phase 2: March 2008

1POT

37.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01507
(show subtarget assignments)

1

in_crystallization_trials

No

VC2045

15642047

superoxide dismutase, Fe

194

Conserved Gene / Pathway

Phase 2: March 2008

2W7W

86.6%

Vibrio cholerae

Cellular processes

Detoxification

IDP01508
(show subtarget assignments)

1

expressed

No

VCA0127

15600898

ribose ABC transporter protein

156

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

48.1%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01509
(show subtarget assignments)

1

expressed

No

VC0549

15640571

oxaloacetate decarboxylase subunit gamma...

117

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01510
(show subtarget assignments)

1

in_crystallization_trials

No

VC0731

15640750

antioxidant, AhpC/Tsa family

207

Conserved Gene / Pathway

Phase 2: March 2008

1ZOF

55.1%

Vibrio cholerae

Cellular processes

Detoxification

IDP01511
(show subtarget assignments)

1

expressed

No

VC0794

15640812

hypothetical protein VC0794

139

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01512
(show subtarget assignments)

1

soluble

No

VC1173

15641186

anthranilate synthase component II

203

Drug Target Function

Phase 2: March 2008

1I1Q

57.1%

Vibrio cholerae

Amino acid biosynthesis

Aromatic amino acid family

IDP01513
(show subtarget assignments)

1

purified

No

VC1312

161582006

alr

alanine racemase

407

Conserved Gene / Pathway

Phase 2: March 2008

4ECL

26%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01514
(show subtarget assignments)

1

purified

No

VCA0518

15601278

fructose-specific PTS IIA/HPr components...

400

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

11.5%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01515
(show subtarget assignments)

1

in_pdb
3ECT
3NZ2

Yes

VCA0836

15601591

hexapeptide-repeat containing-acetyltran...

192

Drug Target Function

Phase 2: March 2008

3ECT

100%

Vibrio cholerae

Central intermediary metabolism

Other

IDP01516
(show subtarget assignments)

1

crystallized

No

VC0576

15640598

sspA

stringent starvation protein A

211

Conserved Gene / Pathway

Phase 2: March 2008

1YY7

73.9%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP01517
(show subtarget assignments)

1

expressed

No

VC1254

15641267

iron-sulfur cluster-binding protein, put...

92

Conserved Gene / Pathway

Phase 2: March 2008

1AWD

26.1%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01518
(show subtarget assignments)

1

purified

No

VC1512

15641521

formate dehydrogenase, iron-sulfur subun...

202

Conserved Gene / Pathway

Phase 2: March 2008

1KQF

29%

Vibrio cholerae

Energy metabolism

Anaerobic

IDP01519
(show subtarget assignments)

1

purified

No

VC2149

15642148

hypothetical protein VC2149

95

Drug Target Function

Phase 2: March 2008

3KE2

43.2%

Vibrio cholerae

IDP01520
(show subtarget assignments)

1

expressed

No

VCA0782

15601537

ABC transporter, ATP-binding protein

225

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

46.7%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01530
(show subtarget assignments)

1

in_pdb
3EFV
3ETF

No

STM1524

16764869

yneI

putative succinate-semialdehyde dehydrog...

462

It is an essential gene in Salmonella which is important in energy metabolism.

Phase 3: June 2008

3EFV

100%

Salmonella enterica

IDP01531
(show subtarget assignments)

1

in_pdb
3EFB

No

SF4094

56384059

sorC

probable sor-operon regulator [Shigella ...

315

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 3: June 2008

2W48

86.3%

Shigella flexneri

IDP01540
(show subtarget assignments)

1

in_pdb
3EC6

No

GBAA0418

47525694

general stress protein 26 [Bacillus anth...

138

CONSERVED

Phase 3: June 2008

3EC6

100%

Bacillus anthracis

IDP01601
(show subtarget assignments)

1

expressed

No

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01602
(show subtarget assignments)

1

expressed

No

YPO2288

16122512

amn

AMP nucleosidase [Yersinia pestis CO92]

546

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

1T8R

63.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01603
(show subtarget assignments)

1

cloned

No

STM1971

16765309

fliH

flagellar assembly protein H [Salmonella...

235

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP01604
(show subtarget assignments)

1

crystallized

No

CBU_0704

29541308

rfbI

lipopolysaccharide/O-antigen ABC transpo...

258

Conserved; Drug target functions

Phase 3: June 2008

3QF4

25.6%

Coxiella burnetii

Transport and binding proteins

Other

IDP01605
(show subtarget assignments)

1

soluble

No

GBAA4560

47529856

hypothetical protein GBAA4560 [Bacillus ...

97

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

1RQ8

67%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP01606
(show subtarget assignments)

1

cloned

No

GBAA4968

47530266

gdH

glucose-1-dehydrogenase [Bacillus anthra...

261

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1GEE

87.7%

Bacillus anthracis

Energy metabolism

Other

IDP01607
(show subtarget assignments)

1

cloned

No

FTT1608

56708628

ABC transporter, ATP-binding protein [Fr...

267

Conserved; Drug target functions

Phase 3: June 2008

3DHW

30%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01608
(show subtarget assignments)

1

cloned

No

CBU_1504

29542063

lepB-2

signal peptidase I [Coxiella burnetii RS...

256

Conserved; Drug target functions

Phase 3: June 2008

1B12

36.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP01609
(show subtarget assignments)

1

crystallized

No

FTT1512c

56708550

dnaJ1

heat shock protein, hsp40 [Francisella t...

308

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

34.2%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01610
(show subtarget assignments)

1

in_pdb
3I1I

No

GBAA4983

47778350

homoserine O-acetyltransferase [Bacillus...

374

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3I1I

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP01611
(show subtarget assignments)

1

in_pdb
3TAU

Yes

lmo1827

16803867

gmk

hypothetical protein lmo1827 [Listeria m...

205

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

3TAU

100%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP01612
(show subtarget assignments)

1

cloned

No

FTT1538c

56708570

hypothetical protein FTT1538c [Francisel...

327

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Amino acids, peptides and aminesCarbohydrates, organic alcohols, and acids

IDP01613
(show subtarget assignments)

1

in_crystallization_trials

No

STM1927

16765269

yecG

universal stress protein UspC [Salmonell...

142

Conserved; Drug target functions

Phase 3: June 2008

1JMV

35.2%

Salmonella enterica

Cellular processes

Adaptations to atypical conditions

IDP01614
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2581

16122794

putative sugar-binding periplasmic prote...

309

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

29.5%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01615
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0643

29541244

ribD

riboflavin biosynthesis protein RibD [Co...

354

Conserved; Drug target functions

Phase 3: June 2008

2HXV

35.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01616
(show subtarget assignments)

1

in_pdb
3EG7

No

VC_A0947

9658384

spermidine n1-acetyltransferase [Vibrio ...

173

CONSERVED

Phase 3: June 2008

3EG7

100%

Vibrio cholerae

N/A

IDP01619
(show subtarget assignments)

1

expressed

No

CBU_1871

29542425

pabA

para-aminobenzoate synthase glutamine am...

201

Conserved; Drug target functions

Phase 3: June 2008

1QDL

44.3%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01620
(show subtarget assignments)

1

cloned

No

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP01621
(show subtarget assignments)

1

cloned

No

STM1984

16765321

yodD

putative cytoplasmic protein [Salmonella...

75

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01622
(show subtarget assignments)

1

cloned

No

STM4396

16767642

ytfB

putative cell envelope opacity-associate...

211

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP01623
(show subtarget assignments)

1

cloned

No

GBAA5019

47530321

pckA

phosphoenolpyruvate carboxykinase [Bacil...

528

Conserved; Essential; Drug target functions

Phase 3: June 2008

1J3B

52.8%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01624
(show subtarget assignments)

1

expressed

No

CBU_1879

29542436

polypeptide deformylase, putative [Coxie...

209

Conserved; Drug target functions

Phase 3: June 2008

1LM6

29.2%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP01625
(show subtarget assignments)

1

expressed

No

FTT1761

56708756

hypothetical protein FTT1761 [Francisell...

239

Drug Target

Phase 3: June 2008

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP01626
(show subtarget assignments)

1

cloned

No

GBAA5017

47530320

metK

S-adenosylmethionine synthetase [Bacillu...

399

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FUG

62.4%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01627
(show subtarget assignments)

1

cloned

No

GBAA0530

50196914

glutamate synthase, large subunit, putat...

1478

Conserved; Drug target functions

Phase 3: June 2008

1EA0

29.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

Targets