Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00542 (show subtarget assignments)	1	cloned	No	YPO2744	16122948	fadL	long-chain fatty acid outer membrane tra...	423	Virulence Associated Factor	Phase 2: March 2008	1T16	64%	Yersinia pestis	Cell envelope	Other

IDP01498 (show subtarget assignments)	1	expressed	No	VCA0862	15601617		long-chain fatty acid transport protein ...	412	Conserved Gene / Pathway	Phase 2: March 2008	1T16	39.2%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01343 (show subtarget assignments)	1	cloned	No	VC2649	15642644	cysE	serine acetyltransferase	273	Drug Target Function	Phase 2: March 2008	1T3D	72.2%	Vibrio cholerae	Amino acid biosynthesis	Serine family

IDP01704 (show subtarget assignments)	1	expressed	No	GBAA5215	47530521		aminotransferase, class V [Bacillus anth...	406	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T3I	51%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP05494 (show subtarget assignments)	1	soluble	No	CD0234	126697805	csrA	carbon storage regulator [Clostridium di...	70	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1T3O	47.1%	Clostridium difficile	Regulatory functions: RNA interactions

IDP04499 (show subtarget assignments)	1	cloned	No	VC0869	15640885		phosphoribosylformylglycinamidine syntha...	1297	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	73.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04400 (show subtarget assignments)	1	cloned	No	YPO2921	218929976	purL	phosphoribosylformylglycinamidine syntha...	1296	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	82.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04656 (show subtarget assignments)	1	cloned	No	FTT1720c	56708726	purL	phosphoribosylformylglycinamidine syntha...	1290	conserved gene; putative drug target function;	Phase 4: April 2009	1T3T	55.8%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00974 (show subtarget assignments)	1	in_crystallization_trials	No	STM1775	16765116	hemK	N5-glutamine S-adenosyl-L-methionine-dep...	277	Essential Gene	Phase 2: March 2008	1T43	76.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP01630 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1964	29542519	hemK	protein methyltransferase HemK [Coxiella...	277	Conserved; Drug target functions	Phase 3: June 2008	1T43	42.6%	Coxiella burnetii	Protein fate	Protein modification and repair

IDP04360 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2018	115347740		putative protoporphyrinogen oxidase [Yer...	276	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1T43	62.3%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00614 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2109	57286325		modification methylase, HemK family	278	Drug Target Function	Phase 2: March 2008	1T43	32%	Staphylococcus aureus	Unknown function	General

IDP90514 (show subtarget assignments)	8	crystallized	No	Cj0513	15791875		phosphoribosylformylglycinamidine syntha...	81	Predicted Essential	Community Requests	1T4A	46.9%	Campylobacter jejuni

IDP04320 (show subtarget assignments)	1	in_pdb 4ESE	No	YPO2323	115348026	acpD	acyl carrier protein phosphodiesterase [...	201	conserved gene; putative drug target function;	Phase 4: April 2009	1T5B	81.1%	Yersinia pestis	Fatty acid and phospholipid metabolism	Other

IDP02813 (show subtarget assignments)	1	cloned	No	Cj0367c	15791734		RND efflux system, membrane fusion prote...	367	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	1T5E	29.2%	Campylobacter jejuni	Regulatory functions	Other

IDP01754 (show subtarget assignments)	1	expressed	No	CBU_0803	29541397		efflux transporter, RND family, MFP subu...	351	Conserved; Drug target functions	Phase 3: June 2008	1T5E	27.9%	Coxiella burnetii	Transport and binding proteins	Other

IDP00069 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0342	16418853	STM0352	putative cation efflux pump	408	Virulence	Phase 1: October 2007	1T5E	31.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP00631 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1537	57284636	scpB	segregation and condensation protein B	180	Conserved Gene / Pathway	Phase 2: March 2008	1T6S	23.9%	Staphylococcus aureus	Cellular processes	Cell division

IDP00716 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1420	57286071		phosphate transport system protein PhoU,...	213	Conserved Gene / Pathway	Phase 2: March 2008	1T72	31%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP00572 (show subtarget assignments)	1	cloned	No	YPO2717	16122921	lepB	lsignal peptidase I	332	Drug Target Function	Phase 2: March 2008	1T7D	54.8%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP01932 (show subtarget assignments)	1	cloned	No	CBU_1099	29541673	lepB-1	signal peptidase I [Coxiella burnetii RS...	259	Conserved; Drug target functions	Phase 3: June 2008	1T7D	33.2%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02489 (show subtarget assignments)	1	selected	No	GBAA3099	47528392	sipU	Signal peptidase I U [Bacillus anthracis...	183	Drug target motif; Drug target functions	Phase 3: June 2008	1T7D	27.8%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01602 (show subtarget assignments)	1	expressed	No	YPO2288	16122512	amn	AMP nucleosidase [Yersinia pestis CO92]	546	CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...	Phase 3: June 2008	1T8R	63.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02683 (show subtarget assignments)	1	cloned	No	GBAA2008	47527306		ribosome-associated GTPase [Bacillus ant...	364	Conserved; Essential;	Phase 3: June 2008	1T9H	25.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04609 (show subtarget assignments)	1	soluble	No	BAS3712	49186711		ribosome-associated GTPase [Bacillus ant...	293	Proposed to be essential proteins	Phase 4: April 2009	1T9H	63.4%	Bacillus anthracis

IDP02515 (show subtarget assignments)	1	cloned	No	YPO2567	16122785	pta	phosphate acetyltransferase [Yersinia pe...	717	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	1TD9	20.6%	Yersinia pestis	Energy metabolism	Fermentation

IDP01848 (show subtarget assignments)	1	cloned	No	FTT1754	56708752	pta	phosphate acetyltransferase [Francisella...	698	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1TD9	19.9%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP91399 (show subtarget assignments)	8	soluble	No	VV1_1028	27364461		threonine dehydratase [Vibrio vulnificus...	509	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1TDJ	70.1%	Vibrio vulnificus

IDP90613 (show subtarget assignments)	8	soluble	No	Cj0828c	15792166	ilvA	threonine dehydratase [Campylobacter jej...	403	Predicted Essential	Community Requests	1TDJ	32.8%	Campylobacter jejuni

IDP00660 (show subtarget assignments)	1	cloned	No	SACOL0816	57284278	secA	preprotein translocase subunit SecA	843	Drug Target Function	Phase 2: March 2008	1TF2	60.4%	Staphylococcus aureus	Protein fate	Protein and peptide secretion and trafficking

IDP02635 (show subtarget assignments)	1	soluble	No	GBAA5421	47530734	secA	preprotein translocase subunit SecA [Bac...	835	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TF2	72.8%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP04053 (show subtarget assignments)	1	cloned	No	CPF_2307	110801393	spoIIAA	anti-sigma F factor antagonist [Clostrid...	111	conserved gene; putative drug target function;	Phase 4: April 2009	1TH8	45%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02761 (show subtarget assignments)	1	soluble	No	GBAA2380	47527675		alkaline serine protease [Bacillus anthr...	397	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1THM	51.9%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02822 (show subtarget assignments)	1	cloned	No	GBAA4819	47778330	infC	translation initiation factor IF-3 [Baci...	186	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TIG	40.9%	Bacillus anthracis	Protein synthesis	Translation factors

IDP00637 (show subtarget assignments)	1	cloned	No	SACOL1727	57284738	infC	translation initiation factor IF-3	175	Drug Target Function	Phase 2: March 2008	1TIG	37.7%	Staphylococcus aureus	Protein synthesis	Translation factors

IDP00537 (show subtarget assignments)	1	purified	No	YPO3924	16124055	argH	argininosuccinate lyase	457	Conserved Gene / Pathway	Phase 2: March 2008	1TJ7	88.8%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP05591 (show subtarget assignments)	1	purified	No	BA_2975	30257565		putative sugar ABC transporter, sugar-bi...	347	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1TJY	57.1%	Bacillus anthracis	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP91239 (show subtarget assignments)	8	expressed	No	HP0804	2313934		GTP cyclohydrolase II/3,4-dihydroxy-2-bu...	344	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1TKS	28.2%	Helicobacter pylori	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00126 (show subtarget assignments)	1	soluble	No	NT01ST1449	16764525	mviM	putative virulence protein	307	Virulence	Phase 1: October 2007	1TLT	81.4%	Salmonella enterica	Cellular processes	Pathogenesis

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP01451 (show subtarget assignments)	1	purified	No	VC2305	15642303		outer membrane protein OmpK	296	Conserved Gene / Pathway	Phase 2: March 2008	1TLW	26%	Vibrio cholerae	Transport and binding proteins	Nucleosides, purines and pyrimidines

IDP02082 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0080	56707259	tpiA	triosephosphate isomerase [Francisella t...	253	Conserved; Drug target functions	Phase 3: June 2008	1TMH	42.7%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP01992 (show subtarget assignments)	1	expressed	No	STM3822	16767107	torA	trimethylamine N-oxide reductase subunit...	850	Conserved; Drug target functions	Phase 3: June 2008	1TMO	50.5%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02322 (show subtarget assignments)	1	soluble	No	lmo0691	16802733	cheY	chemotaxis response regulator CheY [List...	119	Known virulence-Regulation; PMID:15155625	Phase 3: June 2008	1TMY	63.9%	Listeria monocytogenes	Regulatory functions	Other

IDP00532 (show subtarget assignments)	1	purified	No	YPO2390	16122613	cfa	cyclopropane fatty acyl phospholipid syn...	383	Virulence Associated Factor	Phase 2: March 2008	1TPY	25.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01214 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3460	30257999	cfa	cyclopropane-fatty-acyl-phospholipid syn...	390	Drug Target Function	Phase 2: March 2008	1TPY	25.1%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00803 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1759	57286194		universal stress protein family	166	Conserved Gene / Pathway	Phase 2: March 2008	1TQ8	30.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP91717 (show subtarget assignments)	8	selected	No	NP_054706	7669550	VCL	vinculin isoform meta-VCL [Homo sapiens]...	1134	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1TR2	94%	Homo sapiens

IDP00096 (show subtarget assignments)	1	in_crystallization_trials	No	NTL02SF1070	30040886	ycfO	hypothetical protein S1191	341	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1TR9	55.7%	Shigella flexneri	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00085 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST1174	16419726	nagZ	putative glycosyl hydrolase	341	Virulence	Phase 1: October 2007	1TR9	55.4%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP91829 (show subtarget assignments)	8	soluble	No	b3919	1790353	tpiA	triosephosphate isomerase [Escherichia c...	255	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1TRE	99.6%	Escherichia coli

IDP02470 (show subtarget assignments)	1	purified	No	lmo0865	16802906		hypothetical protein lmo0865 [Listeria m...	557	Predicted involvement in glycosyl group metabolism; DNA binding Motifs	Phase 3: June 2008	1TUO	26.2%	Listeria monocytogenes	Energy metabolism	Sugars

IDP02218 (show subtarget assignments)	1	expressed	No	GBAA2133	47778008	narA-1	molybdenum cofactor biosynthesis protein...	337	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1TV7	54.4%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Molybdopterin

IDP02493 (show subtarget assignments)	1	soluble	No	YPO2048	16122287	cutC	copper homeostasis protein CutC [Yersini...	254	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1TWD	54.3%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP91772 (show subtarget assignments)	8	expressed	No	AAR87481	40548828	sul3	dihydropteroate synthase [Escherichia co...	242	drug resistance / Dihydropteroate synthase (sulfonamide resistance)	Community Requests	1TWS	36.4%	Escherichia coli

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP92117 (show subtarget assignments)	8	selected	No	TGME49_073410	237833291		tyrosyl-tRNA synthetase, putative [Toxop...	646	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1TYC	18.7%	Toxoplasma gondii

IDP01433 (show subtarget assignments)	1	purified	No	VC1922	15641924	clpP	ATP-dependent Clp protease proteolytic s...	200	Drug Target Function	Phase 2: March 2008	1TYF	76%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05736 (show subtarget assignments)	1	soluble	No	CD1702A	126699309	thiS	putative thiamine biosynthesis protein [...	64	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1TYG	41.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP02222 (show subtarget assignments)	1	crystallized	No	lmo0484	16802527		heme-degrading monooxygenase IsdG [Liste...	121	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1TZ0	28.9%	Listeria monocytogenes	Hypothetical proteins	Conserved

IDP00583 (show subtarget assignments)	1	expressed	No	YPO2752	16122956	mepA	penicillin-insensitive murein endopeptid...	275	Drug Target Function	Phase 2: March 2008	1TZP	67.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91440 (show subtarget assignments)	8	expressed	No	VV1_0472	27363939	mepA	penicillin-insensitive murein endopeptid...	255	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1TZP	45.1%	Vibrio vulnificus

IDP91437 (show subtarget assignments)	8	soluble	No	VV1_0483	27363947		hypothetical protein VV1_0483 [Vibrio vu...	238	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1U05	49.4%	Vibrio vulnificus

IDP00929 (show subtarget assignments)	1	soluble	No	STM0603	16763980	ybdL	putative aminotransferase	386	Conserved Gene / Pathway	Phase 2: March 2008	1U08	85.5%	Salmonella enterica	Central intermediary metabolism	Other

IDP02212 (show subtarget assignments)	1	cloned	No	CBU_2048	29542599	metE	5-methyltetrahydropteroyltriglutamate--h...	775	Conserved; Drug target functions	Phase 3: June 2008	1U1H	48.5%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04453 (show subtarget assignments)	1	cloned	No	YPO1055	115346834	fabZ	(3R)-hydroxymyristoyl-(acyl carrier prot...	181	conserved gene; putative drug target function;	Phase 4: April 2009	1U1Z	44.2%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04462 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1939	115347664		putative glutaminase [Yersinia pestis CO...	340	putative drug target function;	Phase 4: April 2009	1U60	38.2%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP05661 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0240	16802286	-	hypothetical protein lmo0240 [Listeria m...	136	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1U61	52.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP90209 (show subtarget assignments)	8	expressed	No	MYXV_gp144	9633776	m140R	m140R	553	kelch motif, similar to VACV-Cop:A55R	Community Requests	1U6D	14.3%	Myxoma virus	unknown, conserved protein	0

IDP02550 (show subtarget assignments)	1	in_pdb 3RF0	Yes	YPO2837	16123032	ppx	exopolyphosphatase [Yersinia pestis CO92...	519	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1U6Z	76.3%	Yersinia pestis	Central intermediary metabolism	Phosphorus compounds

IDP04082 (show subtarget assignments)	1	cloned	No	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91253 (show subtarget assignments)	8	soluble	No	NT01LM1950	16411263	plsX	plsX [Listeria monocytogenes]	337	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1U7N	57.6%	Listeria monocytogenes	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00955 (show subtarget assignments)	1	cloned	No	STM1192	16764547	plsX	fatty acid/phospholipid synthesis protei...	359	Conserved Gene / Pathway	Phase 2: March 2008	1U7N	36.5%	Salmonella enterica	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90780 (show subtarget assignments)	8	soluble	No	VC0215	15640245		bifunctional phosphopantothenoylcysteine...	399	Predicted Essential	Community Requests	1U7U	32.8%	Vibrio cholerae

IDP02424 (show subtarget assignments)	1	cloned	No	FTT1147c	56708218	dfp	4'-phosphopantothenoylcysteine decarboxy...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	19.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP00867 (show subtarget assignments)	1	purified	No	STM3730	161353581	dfp	phosphopantothenoylcysteine synthase/dec...	406	Essential Gene	Phase 2: March 2008	1U7U	50.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP90925 (show subtarget assignments)	8	in_crystallization_trials	No	YPO0048	16120401	dfp	phosphopantothenoylcysteine synthase/dec...	405	Predicted Essential	Community Requests	1U7U	40%	Yersinia pestis

IDP02167 (show subtarget assignments)	1	expressed	No	CBU_0886	29541477	coaBC	phosphopantothenoylcysteine decarboxylas...	391	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02721 (show subtarget assignments)	1	soluble	No	GBAA4007	47529300	coaBC	bifunctional phosphopantothenoylcysteine...	401	Conserved; Drug target functions	Phase 3: June 2008	1U7U	23.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP91395 (show subtarget assignments)	8	cloned	No	VV1_1082	27364505		ATP-dependent DNA helicase Rep [Vibrio v...	528	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1UAA	71%	Vibrio vulnificus

IDP05735 (show subtarget assignments)	1	soluble	No	CD1599	126699203	thiD	putative phosphomethylpyrimidine kinase ...	264	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1UB0	44.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP01201 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1826	34098434		3-oxoacyl-[acyl-carrier-protein] synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	40.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00304 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0038	29653401		3-oxoacyl-(acyl-carrier-protein) synthas...	327	Drug Target Function	Phase 2: March 2008	1UB7	29.6%	Coxiella burnetii	Fatty acid and phospholipid metabolism	Biosynthesis

IDP00014 (show subtarget assignments)	1	in_crystallization_trials	No	BA_3915	17368674		Protein recA (Recombinase A)	343	Drug Target Homolog	Phase 1: October 2007	1UBC	65.6%	Bacillus anthracis	DNA metabolism	DNA replication, recombination, and repair

IDP90775 (show subtarget assignments)	8	cloned	No	YPO0345	16120680	dipZ	thiol:disulfide interchange protein prec...	595	Predicted Essential	Community Requests	1UC7	12.8%	Yersinia pestis

IDP02354 (show subtarget assignments)	1	cloned	No	Cj0887c	15792217	flaD	flagellar hook-associated protein [Campy...	750	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	13.9%	Campylobacter jejuni	Cell envelope	Other

IDP02088 (show subtarget assignments)	1	cloned	No	Cj1338c	15792661	flaB	flagellin [Campylobacter jejuni subsp. j...	572	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	27.6%	Campylobacter jejuni	Cell envelope	Surface structures

IDP02570 (show subtarget assignments)	1	cloned	No	Cj1339c	15792662	flaA	flagellin [Campylobacter jejuni subsp. j...	572	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	28%	Campylobacter jejuni	Cell envelope	Surface structures

IDP01790 (show subtarget assignments)	1	purified	No	FTT1731c	56708736	obgE	GTPase ObgE [Francisella tularensis subs...	334	Drug Target	Phase 3: June 2008	1UDX	45.5%	Francisella tularensis	Unknown function	General

IDP02063 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0387	29540997	cgtA	GTP-binding protein, GTP1/Obg family [Co...	339	Conserved; Drug target functions	Phase 3: June 2008	1UDX	46.3%	Coxiella burnetii	Unknown function	General

IDP90353 (show subtarget assignments)	8	expressed	No	CT198	15604918	oppA_3	oligopeptide binding protein [Chlamydia ...	518	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1UIU	25.5%	Chlamydia trachomatis

IDP02320 (show subtarget assignments)	1	purified	No	GBAA1254	47526520	trpA	tryptophan synthase subunit alpha [Bacil...	258	Conserved; Drug target functions	Phase 3: June 2008	1UJP	39.1%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP92143 (show subtarget assignments)	8	selected	No	TGME49_068560	237832503		RAD2 endonuclease, putative [Toxoplasma ...	2004	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1UL1	4.4%	Toxoplasma gondii

IDP92051 (show subtarget assignments)	8	selected	No	TGME49_051620	237836211		flap endonuclease-1, putative [Toxoplasm...	552	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1UL1	31%	Toxoplasma gondii

IDP00544 (show subtarget assignments)	1	purified	No	YPO2746	16122950	fadI	3-ketoacyl-CoA thiolase	436	Virulence Associated Factor	Phase 2: March 2008	1ULQ	37.4%	Yersinia pestis	Cellular processes	Detoxification

IDP01000 (show subtarget assignments)	1	expressed	No	STM2389	16765716	fadI	3-ketoacyl-CoA thiolase	436	Conserved Gene / Pathway	Phase 2: March 2008	1ULQ	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP04655 (show subtarget assignments)	1	soluble	No	FTT1531	56708565	fadA	acetyl-CoA acetyltransferase [Francisell...	395	drug target; conserved gene;	Phase 4: April 2009	1ULQ	45.7%	Francisella tularensis	Fatty acid and phospholipid metabolism	Other

IDP90161 (show subtarget assignments)	8	purified	No	CD1835	123174273		Chorismate synthase (5-enolpyruvylshikim...	359	Potential drug target. Shikimate pathway enzyme	Community Requests	1UM0	38.7%	Clostridium difficile

IDP00542
(show subtarget assignments)

1

cloned

No

YPO2744

16122948

fadL

long-chain fatty acid outer membrane tra...

423

Virulence Associated Factor

Phase 2: March 2008

1T16

64%

Yersinia pestis

Cell envelope

Other

IDP01498
(show subtarget assignments)

1

expressed

No

VCA0862

15601617

long-chain fatty acid transport protein ...

412

Conserved Gene / Pathway

Phase 2: March 2008

1T16

39.2%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01343
(show subtarget assignments)

1

cloned

No

VC2649

15642644

cysE

serine acetyltransferase

273

Drug Target Function

Phase 2: March 2008

1T3D

72.2%

Vibrio cholerae

Amino acid biosynthesis

Serine family

IDP01704
(show subtarget assignments)

1

expressed

No

GBAA5215

47530521

aminotransferase, class V [Bacillus anth...

406

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T3I

51%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP05494
(show subtarget assignments)

1

soluble

No

CD0234

126697805

csrA

carbon storage regulator [Clostridium di...

70

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1T3O

47.1%

Clostridium difficile

Regulatory functions: RNA interactions

IDP04499
(show subtarget assignments)

1

cloned

No

VC0869

15640885

phosphoribosylformylglycinamidine syntha...

1297

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

73.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04400
(show subtarget assignments)

1

cloned

No

YPO2921

218929976

purL

phosphoribosylformylglycinamidine syntha...

1296

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

82.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04656
(show subtarget assignments)

1

cloned

No

FTT1720c

56708726

purL

phosphoribosylformylglycinamidine syntha...

1290

conserved gene; putative drug target function;

Phase 4: April 2009

1T3T

55.8%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00974
(show subtarget assignments)

1

in_crystallization_trials

No

STM1775

16765116

hemK

N5-glutamine S-adenosyl-L-methionine-dep...

277

Essential Gene

Phase 2: March 2008

1T43

76.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP01630
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1964

29542519

hemK

protein methyltransferase HemK [Coxiella...

277

Conserved; Drug target functions

Phase 3: June 2008

1T43

42.6%

Coxiella burnetii

Protein fate

Protein modification and repair

IDP04360
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2018

115347740

putative protoporphyrinogen oxidase [Yer...

276

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1T43

62.3%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00614
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2109

57286325

modification methylase, HemK family

278

Drug Target Function

Phase 2: March 2008

1T43

32%

Staphylococcus aureus

Unknown function

General

IDP90514
(show subtarget assignments)

8

crystallized

No

Cj0513

15791875

phosphoribosylformylglycinamidine syntha...

81

Predicted Essential

Community Requests

1T4A

46.9%

Campylobacter jejuni

IDP04320
(show subtarget assignments)

1

in_pdb
4ESE

No

YPO2323

115348026

acpD

acyl carrier protein phosphodiesterase [...

201

conserved gene; putative drug target function;

Phase 4: April 2009

1T5B

81.1%

Yersinia pestis

Fatty acid and phospholipid metabolism

Other

IDP02813
(show subtarget assignments)

1

cloned

No

Cj0367c

15791734

RND efflux system, membrane fusion prote...

367

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

1T5E

29.2%

Campylobacter jejuni

Regulatory functions

Other

IDP01754
(show subtarget assignments)

1

expressed

No

CBU_0803

29541397

efflux transporter, RND family, MFP subu...

351

Conserved; Drug target functions

Phase 3: June 2008

1T5E

27.9%

Coxiella burnetii

Transport and binding proteins

Other

IDP00069
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0342

16418853

STM0352

putative cation efflux pump

408

Virulence

Phase 1: October 2007

1T5E

31.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP00631
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1537

57284636

scpB

segregation and condensation protein B

180

Conserved Gene / Pathway

Phase 2: March 2008

1T6S

23.9%

Staphylococcus aureus

Cellular processes

Cell division

IDP00716
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1420

57286071

phosphate transport system protein PhoU,...

213

Conserved Gene / Pathway

Phase 2: March 2008

1T72

31%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP00572
(show subtarget assignments)

1

cloned

No

YPO2717

16122921

lepB

lsignal peptidase I

332

Drug Target Function

Phase 2: March 2008

1T7D

54.8%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP01932
(show subtarget assignments)

1

cloned

No

CBU_1099

29541673

lepB-1

signal peptidase I [Coxiella burnetii RS...

259

Conserved; Drug target functions

Phase 3: June 2008

1T7D

33.2%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02489
(show subtarget assignments)

1

selected

No

GBAA3099

47528392

sipU

Signal peptidase I U [Bacillus anthracis...

183

Drug target motif; Drug target functions

Phase 3: June 2008

1T7D

27.8%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01602
(show subtarget assignments)

1

expressed

No

YPO2288

16122512

amn

AMP nucleosidase [Yersinia pestis CO92]

546

CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulence; Dru...

Phase 3: June 2008

1T8R

63.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02683
(show subtarget assignments)

1

cloned

No

GBAA2008

47527306

ribosome-associated GTPase [Bacillus ant...

364

Conserved; Essential;

Phase 3: June 2008

1T9H

25.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04609
(show subtarget assignments)

1

soluble

No

BAS3712

49186711

ribosome-associated GTPase [Bacillus ant...

293

Proposed to be essential proteins

Phase 4: April 2009

1T9H

63.4%

Bacillus anthracis

IDP02515
(show subtarget assignments)

1

cloned

No

YPO2567

16122785

pta

phosphate acetyltransferase [Yersinia pe...

717

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

1TD9

20.6%

Yersinia pestis

Energy metabolism

Fermentation

IDP01848
(show subtarget assignments)

1

cloned

No

FTT1754

56708752

pta

phosphate acetyltransferase [Francisella...

698

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1TD9

19.9%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP91399
(show subtarget assignments)

8

soluble

No

VV1_1028

27364461

threonine dehydratase [Vibrio vulnificus...

509

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1TDJ

70.1%

Vibrio vulnificus

IDP90613
(show subtarget assignments)

8

soluble

No

Cj0828c

15792166

ilvA

threonine dehydratase [Campylobacter jej...

403

Predicted Essential

Community Requests

1TDJ

32.8%

Campylobacter jejuni

IDP00660
(show subtarget assignments)

1

cloned

No

SACOL0816

57284278

secA

preprotein translocase subunit SecA

843

Drug Target Function

Phase 2: March 2008

1TF2

60.4%

Staphylococcus aureus

Protein fate

Protein and peptide secretion and trafficking

IDP02635
(show subtarget assignments)

1

soluble

No

GBAA5421

47530734

secA

preprotein translocase subunit SecA [Bac...

835

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TF2

72.8%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP04053
(show subtarget assignments)

1

cloned

No

CPF_2307

110801393

spoIIAA

anti-sigma F factor antagonist [Clostrid...

111

conserved gene; putative drug target function;

Phase 4: April 2009

1TH8

45%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02761
(show subtarget assignments)

1

soluble

No

GBAA2380

47527675

alkaline serine protease [Bacillus anthr...

397

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1THM

51.9%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02822
(show subtarget assignments)

1

cloned

No

GBAA4819

47778330

infC

translation initiation factor IF-3 [Baci...

186

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TIG

40.9%

Bacillus anthracis

Protein synthesis

Translation factors

IDP00637
(show subtarget assignments)

1

cloned

No

SACOL1727

57284738

infC

translation initiation factor IF-3

175

Drug Target Function

Phase 2: March 2008

1TIG

37.7%

Staphylococcus aureus

Protein synthesis

Translation factors

IDP00537
(show subtarget assignments)

1

purified

No

YPO3924

16124055

argH

argininosuccinate lyase

457

Conserved Gene / Pathway

Phase 2: March 2008

1TJ7

88.8%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP05591
(show subtarget assignments)

1

purified

No

BA_2975

30257565

putative sugar ABC transporter, sugar-bi...

347

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1TJY

57.1%

Bacillus anthracis

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP91239
(show subtarget assignments)

8

expressed

No

HP0804

2313934

GTP cyclohydrolase II/3,4-dihydroxy-2-bu...

344

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1TKS

28.2%

Helicobacter pylori

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP00126
(show subtarget assignments)

1

soluble

No

NT01ST1449

16764525

mviM

putative virulence protein

307

Virulence

Phase 1: October 2007

1TLT

81.4%

Salmonella enterica

Cellular processes

Pathogenesis

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP01451
(show subtarget assignments)

1

purified

No

VC2305

15642303

outer membrane protein OmpK

296

Conserved Gene / Pathway

Phase 2: March 2008

1TLW

26%

Vibrio cholerae

Transport and binding proteins

Nucleosides, purines and pyrimidines

IDP02082
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0080

56707259

tpiA

triosephosphate isomerase [Francisella t...

253

Conserved; Drug target functions

Phase 3: June 2008

1TMH

42.7%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP01992
(show subtarget assignments)

1

expressed

No

STM3822

16767107

torA

trimethylamine N-oxide reductase subunit...

850

Conserved; Drug target functions

Phase 3: June 2008

1TMO

50.5%

Salmonella enterica

Energy metabolism

Anaerobic

IDP02322
(show subtarget assignments)

1

soluble

No

lmo0691

16802733

cheY

chemotaxis response regulator CheY [List...

119

Known virulence-Regulation; PMID:15155625

Phase 3: June 2008

1TMY

63.9%

Listeria monocytogenes

Regulatory functions

Other

IDP00532
(show subtarget assignments)

1

purified

No

YPO2390

16122613

cfa

cyclopropane fatty acyl phospholipid syn...

383

Virulence Associated Factor

Phase 2: March 2008

1TPY

25.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01214
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3460

30257999

cfa

cyclopropane-fatty-acyl-phospholipid syn...

390

Drug Target Function

Phase 2: March 2008

1TPY

25.1%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00803
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1759

57286194

universal stress protein family

166

Conserved Gene / Pathway

Phase 2: March 2008

1TQ8

30.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP91717
(show subtarget assignments)

8

selected

No

NP_054706

7669550

VCL

vinculin isoform meta-VCL [Homo sapiens]...

1134

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1TR2

94%

Homo sapiens

IDP00096
(show subtarget assignments)

1

in_crystallization_trials

No

NTL02SF1070

30040886

ycfO

hypothetical protein S1191

341

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1TR9

55.7%

Shigella flexneri

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00085
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST1174

16419726

nagZ

putative glycosyl hydrolase

341

Virulence

Phase 1: October 2007

1TR9

55.4%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP91829
(show subtarget assignments)

8

soluble

No

b3919

1790353

tpiA

triosephosphate isomerase [Escherichia c...

255

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1TRE

99.6%

Escherichia coli

IDP02470
(show subtarget assignments)

1

purified

No

lmo0865

16802906

hypothetical protein lmo0865 [Listeria m...

557

Predicted involvement in glycosyl group metabolism; DNA binding Motifs

Phase 3: June 2008

1TUO

26.2%

Listeria monocytogenes

Energy metabolism

Sugars

IDP02218
(show subtarget assignments)

1

expressed

No

GBAA2133

47778008

narA-1

molybdenum cofactor biosynthesis protein...

337

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1TV7

54.4%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Molybdopterin

IDP02493
(show subtarget assignments)

1

soluble

No

YPO2048

16122287

cutC

copper homeostasis protein CutC [Yersini...

254

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1TWD

54.3%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP91772
(show subtarget assignments)

8

expressed

No

AAR87481

40548828

sul3

dihydropteroate synthase [Escherichia co...

242

drug resistance / Dihydropteroate synthase (sulfonamide resistance)

Community Requests

1TWS

36.4%

Escherichia coli

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP92117
(show subtarget assignments)

8

selected

No

TGME49_073410

237833291

tyrosyl-tRNA synthetase, putative [Toxop...

646

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1TYC

18.7%

Toxoplasma gondii

IDP01433
(show subtarget assignments)

1

purified

No

VC1922

15641924

clpP

ATP-dependent Clp protease proteolytic s...

200

Drug Target Function

Phase 2: March 2008

1TYF

76%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05736
(show subtarget assignments)

1

soluble

No

CD1702A

126699309

thiS

putative thiamine biosynthesis protein [...

64

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1TYG

41.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP02222
(show subtarget assignments)

1

crystallized

No

lmo0484

16802527

heme-degrading monooxygenase IsdG [Liste...

121

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1TZ0

28.9%

Listeria monocytogenes

Hypothetical proteins

Conserved

IDP00583
(show subtarget assignments)

1

expressed

No

YPO2752

16122956

mepA

penicillin-insensitive murein endopeptid...

275

Drug Target Function

Phase 2: March 2008

1TZP

67.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91440
(show subtarget assignments)

8

expressed

No

VV1_0472

27363939

mepA

penicillin-insensitive murein endopeptid...

255

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1TZP

45.1%

Vibrio vulnificus

IDP91437
(show subtarget assignments)

8

soluble

No

VV1_0483

27363947

hypothetical protein VV1_0483 [Vibrio vu...

238

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1U05

49.4%

Vibrio vulnificus

IDP00929
(show subtarget assignments)

1

soluble

No

STM0603

16763980

ybdL

putative aminotransferase

386

Conserved Gene / Pathway

Phase 2: March 2008

1U08

85.5%

Salmonella enterica

Central intermediary metabolism

Other

IDP02212
(show subtarget assignments)

1

cloned

No

CBU_2048

29542599

metE

5-methyltetrahydropteroyltriglutamate--h...

775

Conserved; Drug target functions

Phase 3: June 2008

1U1H

48.5%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04453
(show subtarget assignments)

1

cloned

No

YPO1055

115346834

fabZ

(3R)-hydroxymyristoyl-(acyl carrier prot...

181

conserved gene; putative drug target function;

Phase 4: April 2009

1U1Z

44.2%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04462
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1939

115347664

putative glutaminase [Yersinia pestis CO...

340

putative drug target function;

Phase 4: April 2009

1U60

38.2%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP05661
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0240

16802286

-

hypothetical protein lmo0240 [Listeria m...

136

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1U61

52.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP90209
(show subtarget assignments)

8

expressed

No

MYXV_gp144

9633776

m140R

553

kelch motif, similar to VACV-Cop:A55R

Community Requests

1U6D

14.3%

Myxoma virus

unknown, conserved protein

0

IDP02550
(show subtarget assignments)

1

in_pdb
3RF0

Yes

YPO2837

16123032

ppx

exopolyphosphatase [Yersinia pestis CO92...

519

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1U6Z

76.3%

Yersinia pestis

Central intermediary metabolism

Phosphorus compounds

IDP04082
(show subtarget assignments)

1

cloned

No

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91253
(show subtarget assignments)

8

soluble

No

NT01LM1950

16411263

plsX

plsX [Listeria monocytogenes]

337

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1U7N

57.6%

Listeria monocytogenes

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00955
(show subtarget assignments)

1

cloned

No

STM1192

16764547

plsX

fatty acid/phospholipid synthesis protei...

359

Conserved Gene / Pathway

Phase 2: March 2008

1U7N

36.5%

Salmonella enterica

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90780
(show subtarget assignments)

8

soluble

No

VC0215

15640245

bifunctional phosphopantothenoylcysteine...

399

Predicted Essential

Community Requests

1U7U

32.8%

Vibrio cholerae

IDP02424
(show subtarget assignments)

1

cloned

No

FTT1147c

56708218

dfp

4'-phosphopantothenoylcysteine decarboxy...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

19.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP00867
(show subtarget assignments)

1

purified

No

STM3730

161353581

dfp

phosphopantothenoylcysteine synthase/dec...

406

Essential Gene

Phase 2: March 2008

1U7U

50.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP90925
(show subtarget assignments)

8

in_crystallization_trials

No

YPO0048

16120401

dfp

phosphopantothenoylcysteine synthase/dec...

405

Predicted Essential

Community Requests

1U7U

40%

Yersinia pestis

IDP02167
(show subtarget assignments)

1

expressed

No

CBU_0886

29541477

coaBC

phosphopantothenoylcysteine decarboxylas...

391

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02721
(show subtarget assignments)

1

soluble

No

GBAA4007

47529300

coaBC

bifunctional phosphopantothenoylcysteine...

401

Conserved; Drug target functions

Phase 3: June 2008

1U7U

23.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP91395
(show subtarget assignments)

8

cloned

No

VV1_1082

27364505

ATP-dependent DNA helicase Rep [Vibrio v...

528

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1UAA

71%

Vibrio vulnificus

IDP05735
(show subtarget assignments)

1

soluble

No

CD1599

126699203

thiD

putative phosphomethylpyrimidine kinase ...

264

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1UB0

44.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP01201
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1826

34098434

3-oxoacyl-[acyl-carrier-protein] synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

40.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00304
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0038

29653401

3-oxoacyl-(acyl-carrier-protein) synthas...

327

Drug Target Function

Phase 2: March 2008

1UB7

29.6%

Coxiella burnetii

Fatty acid and phospholipid metabolism

Biosynthesis

IDP00014
(show subtarget assignments)

1

in_crystallization_trials

No

BA_3915

17368674

Protein recA (Recombinase A)

343

Drug Target Homolog

Phase 1: October 2007

1UBC

65.6%

Bacillus anthracis

DNA metabolism

DNA replication, recombination, and repair

IDP90775
(show subtarget assignments)

8

cloned

No

YPO0345

16120680

dipZ

thiol:disulfide interchange protein prec...

595

Predicted Essential

Community Requests

1UC7

12.8%

Yersinia pestis

IDP02354
(show subtarget assignments)

1

cloned

No

Cj0887c

15792217

flaD

flagellar hook-associated protein [Campy...

750

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

13.9%

Campylobacter jejuni

Cell envelope

Other

IDP02088
(show subtarget assignments)

1

cloned

No

Cj1338c

15792661

flaB

flagellin [Campylobacter jejuni subsp. j...

572

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

27.6%

Campylobacter jejuni

Cell envelope

Surface structures

IDP02570
(show subtarget assignments)

1

cloned

No

Cj1339c

15792662

flaA

flagellin [Campylobacter jejuni subsp. j...

572

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

28%

Campylobacter jejuni

Cell envelope

Surface structures

IDP01790
(show subtarget assignments)

1

purified

No

FTT1731c

56708736

obgE

GTPase ObgE [Francisella tularensis subs...

334

Drug Target

Phase 3: June 2008

1UDX

45.5%

Francisella tularensis

Unknown function

General

IDP02063
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0387

29540997

cgtA

GTP-binding protein, GTP1/Obg family [Co...

339

Conserved; Drug target functions

Phase 3: June 2008

1UDX

46.3%

Coxiella burnetii

Unknown function

General

IDP90353
(show subtarget assignments)

8

expressed

No

CT198

15604918

oppA_3

oligopeptide binding protein [Chlamydia ...

518

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1UIU

25.5%

Chlamydia trachomatis

IDP02320
(show subtarget assignments)

1

purified

No

GBAA1254

47526520

trpA

tryptophan synthase subunit alpha [Bacil...

258

Conserved; Drug target functions

Phase 3: June 2008

1UJP

39.1%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP92143
(show subtarget assignments)

8

selected

No

TGME49_068560

237832503

RAD2 endonuclease, putative [Toxoplasma ...

2004

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1UL1

4.4%

Toxoplasma gondii

IDP92051
(show subtarget assignments)

8

selected

No

TGME49_051620

237836211

flap endonuclease-1, putative [Toxoplasm...

552

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1UL1

31%

Toxoplasma gondii

IDP00544
(show subtarget assignments)

1

purified

No

YPO2746

16122950

fadI

3-ketoacyl-CoA thiolase

436

Virulence Associated Factor

Phase 2: March 2008

1ULQ

37.4%

Yersinia pestis

Cellular processes

Detoxification

IDP01000
(show subtarget assignments)

1

expressed

No

STM2389

16765716

fadI

3-ketoacyl-CoA thiolase

436

Conserved Gene / Pathway

Phase 2: March 2008

1ULQ

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP04655
(show subtarget assignments)

1

soluble

No

FTT1531

56708565

fadA

acetyl-CoA acetyltransferase [Francisell...

395

drug target; conserved gene;

Phase 4: April 2009

1ULQ

45.7%

Francisella tularensis

Fatty acid and phospholipid metabolism

Other

IDP90161
(show subtarget assignments)

8

purified

No

CD1835

123174273

Chorismate synthase (5-enolpyruvylshikim...

359

Potential drug target. Shikimate pathway enzyme

Community Requests

1UM0

38.7%

Clostridium difficile