Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02331 (show subtarget assignments)	1	selected	No	GBAA2661	47527952	adP-1	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	30.7%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00025 (show subtarget assignments)	1	purified	No	BA_0285	30253779		bacitracin ABC transporter, ATP-binding ...	309	Virulence	Phase 1: October 2007	1OXS	30.7%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01850 (show subtarget assignments)	1	cloned	No	FTT0916c	56708017	ribF	riboflavin biosynthesis protein RibF [Fr...	306	Drug Target	Phase 3: June 2008	1MRZ	30.7%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP91736 (show subtarget assignments)	8	selected	No	Q51451_PSEAE	0			453	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1R4T	30.7%	Pseudomonas aeruginosa

IDP92018 (show subtarget assignments)	8	selected	No	TGME49_100260	237844903		threonyl-tRNA synthetase, putative [Toxo...	844	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1QF6	30.7%	Toxoplasma gondii

IDP00803 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1759	57286194		universal stress protein family	166	Conserved Gene / Pathway	Phase 2: March 2008	1TQ8	30.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP05475 (show subtarget assignments)	1	expressed	No	BA_2860	30257458		hydrolase, CocE/NonD family [Bacillus an...	597	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1LNS	30.7%	Bacillus anthracis	Unknown function: Enzymes of unknown specificity

IDP05031 (show subtarget assignments)	1	soluble	No	BA_0908	30254654		oligopeptide ABC transporter, oligopepti...	528	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	30.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP90907 (show subtarget assignments)	8	purified	No	STM0643	16764020	cobC	alpha ribazole-5'-P phosphatase [Salmone...	202	Predicted Essential	Community Requests	2P9Z	30.7%	Salmonella enterica

IDP02048 (show subtarget assignments)	1	expressed	No	STM3737	16767022		putative Zn-dependent hydrolase [Salmone...	293	Conserved; Drug target functions	Phase 3: June 2008	1JT1	30.7%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP04153 (show subtarget assignments)	1	cloned	No	YPO3975	218930970	opdA	oligopeptidase A [Yersinia pestis CO92]	680	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1S4B	30.7%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04085 (show subtarget assignments)	1	expressed	No	VC0525	15640547		2-amino-4-hydroxy-6-hydroxymethyldihydro...	195	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2BMB	30.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90346 (show subtarget assignments)	8	cloned	No	CT344	15605067	lon	ATP-dependent protease La [Chlamydia tra...	819	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3M6A	30.8%	Chlamydia trachomatis

IDP00943 (show subtarget assignments)	1	crystallized	No	STM0862	16764224	yliJ	putative glutathione S-transferase	208	Conserved Gene / Pathway	Phase 2: March 2008	4ECI	30.8%	Salmonella enterica	Cellular processes	Detoxification

IDP91931 (show subtarget assignments)	8	expressed	No	SpneCM_010100007426	298255416		zinc transport system ATP-binding protei...	234	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3FVQ	30.8%	Streptococcus pneumoniae

IDP02791 (show subtarget assignments)	1	cloned	No	lmo1892	16803931	pbpA	hypothetical protein lmo1892 [Listeria m...	827	Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...	Phase 3: June 2008	2OLU	30.8%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90503 (show subtarget assignments)	8	purified	No	NP_230169	15642769		DNA primase [Vibrio cholerae O1 biovar e...	587	Predicted Essential	Community Requests	1DD9	30.8%	Vibrio cholerae

IDP00814 (show subtarget assignments)	1	purified	No	SACOL2006	57284880		Aerolysin/Leukocidin family protein	351	Conserved Gene / Pathway	Phase 2: March 2008	3ROH	30.8%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP91278 (show subtarget assignments)	8	cloned	No	NT05BA4419	49181159		RNA polymerase sigma-27 factor [Bacillus...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L9U	30.8%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP00715 (show subtarget assignments)	1	cloned	No	SACOL1414	57286065		peptide ABC transporter, ATP-binding pro...	233	Conserved Gene / Pathway	Phase 2: March 2008	3QF4	30.8%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP01967 (show subtarget assignments)	1	soluble	No	STM1789	16765130		hydrogenase 1 maturation protease [Salmo...	198	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	1CFZ	30.8%	Salmonella enterica	Energy metabolism	Aerobic

IDP01951 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0809c	15792147		metallo-beta-lactamase family protein [C...	198	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	2ZWR	30.8%	Campylobacter jejuni	Unknown function	General

IDP05043 (show subtarget assignments)	1	soluble	No	BA_3162	30257734		putative 5'-nucleotidase [Bacillus anthr...	529	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z1A	30.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01165 (show subtarget assignments)	1	expressed	No	BA_5650	30260099		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP05385 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1686	30255979		putative flagellar hook protein FlgE [Ba...	437	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A69	30.9%	Bacillus anthracis	Cellular processes: Chemotaxis and motility

IDP91087 (show subtarget assignments)	8	expressed	No	BMA_3102	52427493		carbohydrate isomerase, KpsF/GutQ family...	327	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	30.9%	Burkholderia mallei	Energy metabolism: Sugars

IDP00883 (show subtarget assignments)	1	expressed	No	STM1755	16765099	ychJ	hypothetical protein STM1755	152	Conserved Gene / Pathway	Phase 2: March 2008	2JQ5	30.9%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP00794 (show subtarget assignments)	1	cloned	No	SACOL1194	57284479	pbp1	penicillin-binding protein 1	744	Drug Target Function	Phase 2: March 2008	1PYY	30.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02623 (show subtarget assignments)	1	cloned	No	Cj1430c	15792748		putative nucleotide-sugar epimerase/dehy...	181	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1DZR	30.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91093 (show subtarget assignments)	0	work_stopped	No	BPSL0538	52208591		conserved hypothetical protein [Burkhold...	327	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	30.9%	Burkholderia pseudomallei

IDP00735 (show subtarget assignments)	1	purified	No	SACOL0959	57285833		NADH-dependent flavin oxidoreductase, Oy...	375	Drug Target Function	Phase 2: March 2008	3L5A	30.9%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP01718 (show subtarget assignments)	1	cloned	No	YPO3473	16123619		hypothetical protein YPO3473 [Yersinia p...	408	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3NFV	30.9%	Yersinia pestis	Cell envelope	Other

IDP00351 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1742	16803782	adeC	hypothetical protein lmo1742	580	Presence of Protease Motifs; Drug Target Homologs	Phase 2: March 2008	3NQB	30.9%	Listeria monocytogenes	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02663 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2182	16804221		hypothetical protein lmo2182 [Listeria m...	259	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2GHI	30.9%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP05678 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1041	16803081	-	hypothetical protein lmo1041 [Listeria m...	256	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1AMF	30.9%	Listeria monocytogenes	Transport and binding proteins: Cations and iron carrying compounds

IDP91031 (show subtarget assignments)	8	cloned	No	y4125	22127993		solute-binding periplasmic protein precu...	284	other biological interest / highly abundant periplasmic protein with unknown function	Community Requests	1XT8	31%	Yersinia pestis

IDP90719 (show subtarget assignments)	8	soluble	No	Cj0503c	15791865	hemH	ferrochelatase [Campylobacter jejuni sub...	303	Predicted Essential	Community Requests	2PO7	31%	Campylobacter jejuni

IDP00716 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1420	57286071		phosphate transport system protein PhoU,...	213	Conserved Gene / Pathway	Phase 2: March 2008	1T72	31%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP92051 (show subtarget assignments)	8	selected	No	TGME49_051620	237836211		flap endonuclease-1, putative [Toxoplasm...	552	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1UL1	31%	Toxoplasma gondii

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP90516 (show subtarget assignments)	8	expressed	No	Cj0535	15791896	oorD	2-oxoglutarate-acceptor oxidoreductase s...	103	Predicted Essential	Community Requests	1HFE	31.1%	Campylobacter jejuni

IDP91356 (show subtarget assignments)	8	cloned	No	VV1_2923	27366200		DNA-binding protein H-NS [Vibrio vulnifi...	135	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1OV9	31.1%	Vibrio vulnificus

IDP90894 (show subtarget assignments)	8	expressed	No	YPO2046	16122285	argS	arginyl-tRNA synthetase [Yersinia pestis...	576	Predicted Essential	Community Requests	1BS2	31.1%	Yersinia pestis

IDP05542 (show subtarget assignments)	1	cloned	No	Cj0508	6967973	pbpA	hypothetical protein Cj0504c [Campylobac...	643	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FWL	31.1%	Campylobacter jejuni	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00928 (show subtarget assignments)	1	in_crystallization_trials	No	STM0602	16763979	ybdH	putative glycerol dehydrogenase	362	Conserved Gene / Pathway	Phase 2: March 2008	1KQ3	31.1%	Salmonella enterica	Central intermediary metabolism	Other

IDP02286 (show subtarget assignments)	1	cloned	No	FTT1029	56708118	dacD	D-alanyl-D-alanine carboxypeptidase (pen...	444	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IT9	31.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05408 (show subtarget assignments)	1	soluble	No	BA_1977	30256632		putative polysaccharide deacetylase [Bac...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	31.1%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00764 (show subtarget assignments)	1	expressed	No	SACOL0447	57286820		phosphoglycerate mutase family protein	193	Drug Target Function	Phase 2: March 2008	1C7Z	31.1%	Staphylococcus aureus	Unknown function	General

IDP90981 (show subtarget assignments)	8	selected	No	y0850	22124761		outer membrane receptor [Yersinia pestis...	731	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	2HDF	31.1%	Yersinia pestis

IDP02268 (show subtarget assignments)	1	expressed	No	FTT1133	56708209	pilB	Type IV pili nucleotide binding protein,...	592	Conserved; Drug target functions	Phase 3: June 2008	1P9R	31.1%	Francisella tularensis	Cell envelope	Surface structures

IDP02457 (show subtarget assignments)	1	expressed	No	FTT1248	56708310		ABC transporter, ATP-binding protein [Fr...	253	Drug Target	Phase 3: June 2008	1B0U	31.1%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02618 (show subtarget assignments)	1	cloned	No	STM2205	16765535	fruK	1-phosphofructokinase [Salmonella typhim...	312	Conserved; Drug target functions	Phase 3: June 2008	3CQD	31.1%	Salmonella enterica	Energy metabolism	Glycolysis/gluconeogenesis

IDP01752 (show subtarget assignments)	1	selected	No	GBAA5282	47778383	nprB	neutral protease B [Bacillus anthracis s...	547	Drug target motif; Conserved; Vaccine Target; Drug target functions	Phase 3: June 2008	1KEI	31.1%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00069 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0342	16418853	STM0352	putative cation efflux pump	408	Virulence	Phase 1: October 2007	1T5E	31.1%	Salmonella enterica	Cellular processes	Toxin production and resistance

IDP00053 (show subtarget assignments)	1	soluble	No	BA_3536	30258071		phenazine biosynthesis protein, PhzF fam...	285	Virulence	Phase 1: October 2007	1QY9	31.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP00500 (show subtarget assignments)	1	purified	No	YPO1784	16122038		putative copper resistance protein	128	Conserved Gene / Pathway	Phase 2: March 2008	1IX2	31.2%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP01870 (show subtarget assignments)	1	cloned	No	GBAA5710	47531047		serine protease [Bacillus anthracis str....	391	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3GCN	31.2%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP02040 (show subtarget assignments)	1	expressed	No	GBAA4637	47529935	relA	GTP pyrophosphokinase [Bacillus anthraci...	727	CONSERVED. Additional information: It is responsible for a down-regulation of RN...	Phase 3: June 2008	1VJ7	31.2%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions	N/A

IDP92017 (show subtarget assignments)	8	selected	No	ADC80544	289064337		glutamine aminoacyl-tRNA synthetase [Tox...	937	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1EUQ	31.2%	Toxoplasma gondii

IDP91923 (show subtarget assignments)	8	purified	No	SpneCM_010100002081	298254388		hypothetical protein SpneCM_02081 [Strep...	170	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1S3R	31.2%	Streptococcus pneumoniae

IDP00837 (show subtarget assignments)	1	purified	No	SACOL2735	57285289		chromosome partioning protein, ParB fami...	279	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	31.2%	Staphylococcus aureus	Cellular processes	Cell division

IDP91402 (show subtarget assignments)	8	purified	No	VV1_1001	27364435		ABC-type amino acid transport, signal tr...	250	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1GGG	31.2%	Vibrio vulnificus

IDP05713 (show subtarget assignments)	1	cloned	No	BA_0189	30253696		oligopeptide ABC transporter, oligopepti...	536	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.2%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP01404 (show subtarget assignments)	1	purified	No	VC0856	15640872		dnaJ protein	381	Conserved Gene / Pathway	Phase 2: March 2008	3LZ8	31.2%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP02739 (show subtarget assignments)	1	purified	No	FTT1321	56708378		peptidase M16 family protein [Francisell...	417	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3AMI	31.2%	Francisella tularensis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05742 (show subtarget assignments)	1	cloned	No	CD2655	126700269	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	457	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1GG4	31.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02391 (show subtarget assignments)	1	cloned	No	FTT0534c	56707667	nrdA	ribonucleotide-diphosphate reductase sub...	590	Drug Target	Phase 3: June 2008	2WGH	31.2%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP02117 (show subtarget assignments)	1	in_crystallization_trials	No	STM4356	16767602	yjeF	hypothetical protein STM4356 [Salmonella...	515	Conserved; Drug target functions	Phase 3: June 2008	2AX3	31.3%	Salmonella enterica	Unknown function	General

IDP00850 (show subtarget assignments)	1	purified	No	SACOL2389	57285120		transcriptional regulatory protein DegU,...	217	Conserved Gene / Pathway	Phase 2: March 2008	1A04	31.3%	Staphylococcus aureus	Cellular processes	Pathogenesis

IDP05387 (show subtarget assignments)	1	purified	No	BA_2041	30256692		putative oligopeptide ABC transporter, o...	553	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	31.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05730 (show subtarget assignments)	1	soluble	No	CD0675	126698254		putative acetyltransferase [Clostridium ...	166	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2GE3	31.3%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP00405 (show subtarget assignments)	1	purified	No	YPO4025	16124148		putative iron ABC transporter, ATP-bindi...	252	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.3%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01779 (show subtarget assignments)	1	soluble	No	CBU_0366	29540977	phoR	sensor histidine kinase PhoR protein, pu...	252	Conserved; Drug target functions	Phase 3: June 2008	2C2A	31.3%	Coxiella burnetii	Signal transduction	Two-component systems

IDP01164 (show subtarget assignments)	1	purified	No	BA_5600	30260056		ABC transporter, ATP-binding protein	300	Conserved Gene / Pathway	Phase 2: March 2008	2YYZ	31.3%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP91272 (show subtarget assignments)	8	cloned	No	NT05BA3926	49180681		RNA polymerase sigma-29 factor [Bacillus...	239	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L0O	31.4%	Bacillus anthracis

IDP00967 (show subtarget assignments)	1	in_crystallization_trials	No	STM1559	16764903		putative glycosyl hydrolase	842	Essential Gene	Phase 2: March 2008	3HJE	31.4%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91217 (show subtarget assignments)	1	expressed	No	FTT_0458	56707600	sspA	stringent starvation protein A, regulato...	210	potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3LYK	31.4%	Francisella tularensis

IDP00954 (show subtarget assignments)	1	in_crystallization_trials	No	STM1189	16764544	maf	Maf-like protein	194	Essential Gene	Phase 2: March 2008	1EX2	31.4%	Salmonella enterica	Cellular processes	Cell division

IDP91540 (show subtarget assignments)	8	selected	No	FTN_0549	118423054	sspA	stringent starvation protein A [Francise...	210	virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.	Community Requests	3LYK	31.4%	Francisella novicida

IDP02606 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0006	16802054	gyrB	DNA gyrase subunit B [Listeria monocytog...	646	Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...	Phase 3: June 2008	1EI1	31.4%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP90509 (show subtarget assignments)	8	purified	No	Cj0347	15791715	trpF	N-(5'phosphoribosyl)anthranilate isomera...	199	Predicted Essential	Community Requests	1DL3	31.4%	Campylobacter jejuni

IDP00170 (show subtarget assignments)	1	soluble	No	VCA0865	15601620	hap	hemagglutinin/protease	609	Virulence	Phase 1: October 2007	1EZM	31.4%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP02566 (show subtarget assignments)	1	purified	No	GBAA3033	50196939	adP-2	alkaline d-peptidase [Bacillus anthracis...	388	Drug target motif; Drug target functions	Phase 3: June 2008	1CEF	31.4%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91075 (show subtarget assignments)	8	cloned	No	jhp0343	15611411	msbA	multi-drug resistance protein [Helicobac...	551	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5W	31.4%	Helicobacter pylori

IDP01781 (show subtarget assignments)	1	expressed	No	Cj1616	15792921	chuC	hemin ABC transporter, ATP-binding prote...	258	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	31.4%	Campylobacter jejuni	Fatty acid and phospholipid metabolism	Biosynthesis

IDP90147 (show subtarget assignments)	8	cloned	No	MPXV_ZAI1979_005_194	68449266		kelch-like protein [Monkeypox virus]	70	similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R	Community Requests	2Q81	31.4%	Monkeypox virus

IDP01351 (show subtarget assignments)	1	cloned	No	VCA0387	15601150		toxin resistance protein	169	Conserved Gene / Pathway	Phase 2: March 2008	1YVO	31.4%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP00333 (show subtarget assignments)	1	crystallized	No	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01929 (show subtarget assignments)	1	cloned	No	lmo1076	16803116		hypothetical protein lmo1076 [Listeria m...	572	Known virulence-Invasion; Possible Vaccine Candidate; PMID:15009888	Phase 3: June 2008	3FI7	31.5%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01853 (show subtarget assignments)	1	cloned	No	CBU_1669	29542228	rpoS	RNA polymerase sigma factor RpoS [Coxiel...	352	Conserved; Drug target functions	Phase 3: June 2008	3IYD	31.5%	Coxiella burnetii	Transcription	Transcription factors

IDP91969 (show subtarget assignments)	8	selected	No	SpneCM_010100009453	298255801		peptidyl-prolyl cis-trans isomerase, cyc...	267	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2A2N	31.5%	Streptococcus pneumoniae

IDP91644 (show subtarget assignments)	8	purified	No	NP_215861	15608485		long-chain-fatty-acid--[acyl-carrier-pro...	521	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	3PBK	31.5%	Mycobacterium tuberculosis

IDP01356 (show subtarget assignments)	1	soluble	No	VC0010	15640042		amino acid ABC transporter, periplasmic ...	248	Conserved Gene / Pathway	Phase 2: March 2008	1GGG	31.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90688 (show subtarget assignments)	8	crystallized	No	Cj1595	15792900	rpoA	DNA-directed RNA polymerase subunit alph...	337	Predicted Essential	Community Requests	3IYD	31.5%	Campylobacter jejuni

IDP02452 (show subtarget assignments)	1	purified	No	GBAA3312	47528597		diaminobutyrate--2-oxoglutarate aminotra...	424	Conserved; Essential; Drug target functions	Phase 3: June 2008	2EH6	31.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP01060 (show subtarget assignments)	1	crystallized	No	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP90167 (show subtarget assignments)	8	purified	No	CD1838	123066836		Shikimate kinase	177	Potential drug target. Shikimate pathway enzyme	Community Requests	2PT5	31.6%	Clostridium difficile

IDP01006 (show subtarget assignments)	1	soluble	No	STM2529	16765849		putative anaerobic dimethylsulfoxide red...	209	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	31.6%	Salmonella enterica	Energy metabolism	Anaerobic

IDP02331
(show subtarget assignments)

1

selected

No

GBAA2661

47527952

adP-1

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

30.7%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00025
(show subtarget assignments)

1

purified

No

BA_0285

30253779

bacitracin ABC transporter, ATP-binding ...

309

Virulence

Phase 1: October 2007

1OXS

30.7%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01850
(show subtarget assignments)

1

cloned

No

FTT0916c

56708017

ribF

riboflavin biosynthesis protein RibF [Fr...

306

Drug Target

Phase 3: June 2008

1MRZ

30.7%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP91736
(show subtarget assignments)

8

selected

No

Q51451_PSEAE

0

453

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1R4T

30.7%

Pseudomonas aeruginosa

IDP92018
(show subtarget assignments)

8

selected

No

TGME49_100260

237844903

threonyl-tRNA synthetase, putative [Toxo...

844

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1QF6

30.7%

Toxoplasma gondii

IDP00803
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1759

57286194

universal stress protein family

166

Conserved Gene / Pathway

Phase 2: March 2008

1TQ8

30.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP05475
(show subtarget assignments)

1

expressed

No

BA_2860

30257458

hydrolase, CocE/NonD family [Bacillus an...

597

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1LNS

30.7%

Bacillus anthracis

Unknown function: Enzymes of unknown specificity

IDP05031
(show subtarget assignments)

1

soluble

No

BA_0908

30254654

oligopeptide ABC transporter, oligopepti...

528

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

30.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP90907
(show subtarget assignments)

8

purified

No

STM0643

16764020

cobC

alpha ribazole-5'-P phosphatase [Salmone...

202

Predicted Essential

Community Requests

2P9Z

30.7%

Salmonella enterica

IDP02048
(show subtarget assignments)

1

expressed

No

STM3737

16767022

putative Zn-dependent hydrolase [Salmone...

293

Conserved; Drug target functions

Phase 3: June 2008

1JT1

30.7%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP04153
(show subtarget assignments)

1

cloned

No

YPO3975

218930970

opdA

oligopeptidase A [Yersinia pestis CO92]

680

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1S4B

30.7%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04085
(show subtarget assignments)

1

expressed

No

VC0525

15640547

2-amino-4-hydroxy-6-hydroxymethyldihydro...

195

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2BMB

30.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90346
(show subtarget assignments)

8

cloned

No

CT344

15605067

lon

ATP-dependent protease La [Chlamydia tra...

819

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3M6A

30.8%

Chlamydia trachomatis

IDP00943
(show subtarget assignments)

1

crystallized

No

STM0862

16764224

yliJ

putative glutathione S-transferase

208

Conserved Gene / Pathway

Phase 2: March 2008

4ECI

30.8%

Salmonella enterica

Cellular processes

Detoxification

IDP91931
(show subtarget assignments)

8

expressed

No

SpneCM_010100007426

298255416

zinc transport system ATP-binding protei...

234

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3FVQ

30.8%

Streptococcus pneumoniae

IDP02791
(show subtarget assignments)

1

cloned

No

lmo1892

16803931

pbpA

hypothetical protein lmo1892 [Listeria m...

827

Possible Vaccine Candidate; Presence of Protease Motifs; Predicted involvement i...

Phase 3: June 2008

2OLU

30.8%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90503
(show subtarget assignments)

8

purified

No

NP_230169

15642769

DNA primase [Vibrio cholerae O1 biovar e...

587

Predicted Essential

Community Requests

1DD9

30.8%

Vibrio cholerae

IDP00814
(show subtarget assignments)

1

purified

No

SACOL2006

57284880

Aerolysin/Leukocidin family protein

351

Conserved Gene / Pathway

Phase 2: March 2008

3ROH

30.8%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP91278
(show subtarget assignments)

8

cloned

No

NT05BA4419

49181159

RNA polymerase sigma-27 factor [Bacillus...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L9U

30.8%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP00715
(show subtarget assignments)

1

cloned

No

SACOL1414

57286065

peptide ABC transporter, ATP-binding pro...

233

Conserved Gene / Pathway

Phase 2: March 2008

3QF4

30.8%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP01967
(show subtarget assignments)

1

soluble

No

STM1789

16765130

hydrogenase 1 maturation protease [Salmo...

198

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

1CFZ

30.8%

Salmonella enterica

Energy metabolism

Aerobic

IDP01951
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0809c

15792147

metallo-beta-lactamase family protein [C...

198

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

2ZWR

30.8%

Campylobacter jejuni

Unknown function

General

IDP05043
(show subtarget assignments)

1

soluble

No

BA_3162

30257734

putative 5'-nucleotidase [Bacillus anthr...

529

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z1A

30.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01165
(show subtarget assignments)

1

expressed

No

BA_5650

30260099

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP05385
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1686

30255979

putative flagellar hook protein FlgE [Ba...

437

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A69

30.9%

Bacillus anthracis

Cellular processes: Chemotaxis and motility

IDP91087
(show subtarget assignments)

8

expressed

No

BMA_3102

52427493

carbohydrate isomerase, KpsF/GutQ family...

327

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

30.9%

Burkholderia mallei

Energy metabolism: Sugars

IDP00883
(show subtarget assignments)

1

expressed

No

STM1755

16765099

ychJ

hypothetical protein STM1755

152

Conserved Gene / Pathway

Phase 2: March 2008

2JQ5

30.9%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP00794
(show subtarget assignments)

1

cloned

No

SACOL1194

57284479

pbp1

penicillin-binding protein 1

744

Drug Target Function

Phase 2: March 2008

1PYY

30.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02623
(show subtarget assignments)

1

cloned

No

Cj1430c

15792748

putative nucleotide-sugar epimerase/dehy...

181

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1DZR

30.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91093
(show subtarget assignments)

0

work_stopped

No

BPSL0538

52208591

conserved hypothetical protein [Burkhold...

327

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

30.9%

Burkholderia pseudomallei

IDP00735
(show subtarget assignments)

1

purified

No

SACOL0959

57285833

NADH-dependent flavin oxidoreductase, Oy...

375

Drug Target Function

Phase 2: March 2008

3L5A

30.9%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP01718
(show subtarget assignments)

1

cloned

No

YPO3473

16123619

hypothetical protein YPO3473 [Yersinia p...

408

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3NFV

30.9%

Yersinia pestis

Cell envelope

Other

IDP00351
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1742

16803782

adeC

hypothetical protein lmo1742

580

Presence of Protease Motifs; Drug Target Homologs

Phase 2: March 2008

3NQB

30.9%

Listeria monocytogenes

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02663
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2182

16804221

hypothetical protein lmo2182 [Listeria m...

259

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2GHI

30.9%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP05678
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1041

16803081

-

hypothetical protein lmo1041 [Listeria m...

256

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1AMF

30.9%

Listeria monocytogenes

Transport and binding proteins: Cations and iron carrying compounds

IDP91031
(show subtarget assignments)

8

cloned

No

y4125

22127993

solute-binding periplasmic protein precu...

284

other biological interest / highly abundant periplasmic protein with unknown function

Community Requests

1XT8

31%

Yersinia pestis

IDP90719
(show subtarget assignments)

8

soluble

No

Cj0503c

15791865

hemH

ferrochelatase [Campylobacter jejuni sub...

303

Predicted Essential

Community Requests

2PO7

31%

Campylobacter jejuni

IDP00716
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1420

57286071

phosphate transport system protein PhoU,...

213

Conserved Gene / Pathway

Phase 2: March 2008

1T72

31%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP92051
(show subtarget assignments)

8

selected

No

TGME49_051620

237836211

flap endonuclease-1, putative [Toxoplasm...

552

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1UL1

31%

Toxoplasma gondii

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP90516
(show subtarget assignments)

8

expressed

No

Cj0535

15791896

oorD

2-oxoglutarate-acceptor oxidoreductase s...

103

Predicted Essential

Community Requests

1HFE

31.1%

Campylobacter jejuni

IDP91356
(show subtarget assignments)

8

cloned

No

VV1_2923

27366200

DNA-binding protein H-NS [Vibrio vulnifi...

135

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1OV9

31.1%

Vibrio vulnificus

IDP90894
(show subtarget assignments)

8

expressed

No

YPO2046

16122285

argS

arginyl-tRNA synthetase [Yersinia pestis...

576

Predicted Essential

Community Requests

1BS2

31.1%

Yersinia pestis

IDP05542
(show subtarget assignments)

1

cloned

No

Cj0508

6967973

pbpA

hypothetical protein Cj0504c [Campylobac...

643

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FWL

31.1%

Campylobacter jejuni

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00928
(show subtarget assignments)

1

in_crystallization_trials

No

STM0602

16763979

ybdH

putative glycerol dehydrogenase

362

Conserved Gene / Pathway

Phase 2: March 2008

1KQ3

31.1%

Salmonella enterica

Central intermediary metabolism

Other

IDP02286
(show subtarget assignments)

1

cloned

No

FTT1029

56708118

dacD

D-alanyl-D-alanine carboxypeptidase (pen...

444

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IT9

31.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05408
(show subtarget assignments)

1

soluble

No

BA_1977

30256632

putative polysaccharide deacetylase [Bac...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

31.1%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00764
(show subtarget assignments)

1

expressed

No

SACOL0447

57286820

phosphoglycerate mutase family protein

193

Drug Target Function

Phase 2: March 2008

1C7Z

31.1%

Staphylococcus aureus

Unknown function

General

IDP90981
(show subtarget assignments)

8

selected

No

y0850

22124761

outer membrane receptor [Yersinia pestis...

731

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

2HDF

31.1%

Yersinia pestis

IDP02268
(show subtarget assignments)

1

expressed

No

FTT1133

56708209

pilB

Type IV pili nucleotide binding protein,...

592

Conserved; Drug target functions

Phase 3: June 2008

1P9R

31.1%

Francisella tularensis

Cell envelope

Surface structures

IDP02457
(show subtarget assignments)

1

expressed

No

FTT1248

56708310

ABC transporter, ATP-binding protein [Fr...

253

Drug Target

Phase 3: June 2008

1B0U

31.1%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02618
(show subtarget assignments)

1

cloned

No

STM2205

16765535

fruK

1-phosphofructokinase [Salmonella typhim...

312

Conserved; Drug target functions

Phase 3: June 2008

3CQD

31.1%

Salmonella enterica

Energy metabolism

Glycolysis/gluconeogenesis

IDP01752
(show subtarget assignments)

1

selected

No

GBAA5282

47778383

nprB

neutral protease B [Bacillus anthracis s...

547

Drug target motif; Conserved; Vaccine Target; Drug target functions

Phase 3: June 2008

1KEI

31.1%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00069
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0342

16418853

STM0352

putative cation efflux pump

408

Virulence

Phase 1: October 2007

1T5E

31.1%

Salmonella enterica

Cellular processes

Toxin production and resistance

IDP00053
(show subtarget assignments)

1

soluble

No

BA_3536

30258071

phenazine biosynthesis protein, PhzF fam...

285

Virulence

Phase 1: October 2007

1QY9

31.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP00500
(show subtarget assignments)

1

purified

No

YPO1784

16122038

putative copper resistance protein

128

Conserved Gene / Pathway

Phase 2: March 2008

1IX2

31.2%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP01870
(show subtarget assignments)

1

cloned

No

GBAA5710

47531047

serine protease [Bacillus anthracis str....

391

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3GCN

31.2%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP02040
(show subtarget assignments)

1

expressed

No

GBAA4637

47529935

relA

GTP pyrophosphokinase [Bacillus anthraci...

727

CONSERVED. Additional information: It is responsible for a down-regulation of RN...

Phase 3: June 2008

1VJ7

31.2%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

N/A

IDP92017
(show subtarget assignments)

8

selected

No

ADC80544

289064337

glutamine aminoacyl-tRNA synthetase [Tox...

937

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1EUQ

31.2%

Toxoplasma gondii

IDP91923
(show subtarget assignments)

8

purified

No

SpneCM_010100002081

298254388

hypothetical protein SpneCM_02081 [Strep...

170

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1S3R

31.2%

Streptococcus pneumoniae

IDP00837
(show subtarget assignments)

1

purified

No

SACOL2735

57285289

chromosome partioning protein, ParB fami...

279

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

31.2%

Staphylococcus aureus

Cellular processes

Cell division

IDP91402
(show subtarget assignments)

8

purified

No

VV1_1001

27364435

ABC-type amino acid transport, signal tr...

250

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1GGG

31.2%

Vibrio vulnificus

IDP05713
(show subtarget assignments)

1

cloned

No

BA_0189

30253696

oligopeptide ABC transporter, oligopepti...

536

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.2%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP01404
(show subtarget assignments)

1

purified

No

VC0856

15640872

dnaJ protein

381

Conserved Gene / Pathway

Phase 2: March 2008

3LZ8

31.2%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP02739
(show subtarget assignments)

1

purified

No

FTT1321

56708378

peptidase M16 family protein [Francisell...

417

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3AMI

31.2%

Francisella tularensis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05742
(show subtarget assignments)

1

cloned

No

CD2655

126700269

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

457

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1GG4

31.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02391
(show subtarget assignments)

1

cloned

No

FTT0534c

56707667

nrdA

ribonucleotide-diphosphate reductase sub...

590

Drug Target

Phase 3: June 2008

2WGH

31.2%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP02117
(show subtarget assignments)

1

in_crystallization_trials

No

STM4356

16767602

yjeF

hypothetical protein STM4356 [Salmonella...

515

Conserved; Drug target functions

Phase 3: June 2008

2AX3

31.3%

Salmonella enterica

Unknown function

General

IDP00850
(show subtarget assignments)

1

purified

No

SACOL2389

57285120

transcriptional regulatory protein DegU,...

217

Conserved Gene / Pathway

Phase 2: March 2008

1A04

31.3%

Staphylococcus aureus

Cellular processes

Pathogenesis

IDP05387
(show subtarget assignments)

1

purified

No

BA_2041

30256692

putative oligopeptide ABC transporter, o...

553

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

31.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05730
(show subtarget assignments)

1

soluble

No

CD0675

126698254

putative acetyltransferase [Clostridium ...

166

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2GE3

31.3%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP00405
(show subtarget assignments)

1

purified

No

YPO4025

16124148

putative iron ABC transporter, ATP-bindi...

252

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.3%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01779
(show subtarget assignments)

1

soluble

No

CBU_0366

29540977

phoR

sensor histidine kinase PhoR protein, pu...

252

Conserved; Drug target functions

Phase 3: June 2008

2C2A

31.3%

Coxiella burnetii

Signal transduction

Two-component systems

IDP01164
(show subtarget assignments)

1

purified

No

BA_5600

30260056

ABC transporter, ATP-binding protein

300

Conserved Gene / Pathway

Phase 2: March 2008

2YYZ

31.3%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP91272
(show subtarget assignments)

8

cloned

No

NT05BA3926

49180681

RNA polymerase sigma-29 factor [Bacillus...

239

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L0O

31.4%

Bacillus anthracis

IDP00967
(show subtarget assignments)

1

in_crystallization_trials

No

STM1559

16764903

putative glycosyl hydrolase

842

Essential Gene

Phase 2: March 2008

3HJE

31.4%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91217
(show subtarget assignments)

1

expressed

No

FTT_0458

56707600

sspA

stringent starvation protein A, regulato...

210

potential drug target; virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3LYK

31.4%

Francisella tularensis

IDP00954
(show subtarget assignments)

1

in_crystallization_trials

No

STM1189

16764544

maf

Maf-like protein

194

Essential Gene

Phase 2: March 2008

1EX2

31.4%

Salmonella enterica

Cellular processes

Cell division

IDP91540
(show subtarget assignments)

8

selected

No

FTN_0549

118423054

sspA

stringent starvation protein A [Francise...

210

virulence/pathogenesis / SspA is a critical regulator of virulence gene expression in F. tularensis.

Community Requests

3LYK

31.4%

Francisella novicida

IDP02606
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0006

16802054

gyrB

DNA gyrase subunit B [Listeria monocytog...

646

Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...

Phase 3: June 2008

1EI1

31.4%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP90509
(show subtarget assignments)

8

purified

No

Cj0347

15791715

trpF

N-(5'phosphoribosyl)anthranilate isomera...

199

Predicted Essential

Community Requests

1DL3

31.4%

Campylobacter jejuni

IDP00170
(show subtarget assignments)

1

soluble

No

VCA0865

15601620

hap

hemagglutinin/protease

609

Virulence

Phase 1: October 2007

1EZM

31.4%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP02566
(show subtarget assignments)

1

purified

No

GBAA3033

50196939

adP-2

alkaline d-peptidase [Bacillus anthracis...

388

Drug target motif; Drug target functions

Phase 3: June 2008

1CEF

31.4%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91075
(show subtarget assignments)

8

cloned

No

jhp0343

15611411

msbA

multi-drug resistance protein [Helicobac...

551

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5W

31.4%

Helicobacter pylori

IDP01781
(show subtarget assignments)

1

expressed

No

Cj1616

15792921

chuC

hemin ABC transporter, ATP-binding prote...

258

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

31.4%

Campylobacter jejuni

Fatty acid and phospholipid metabolism

Biosynthesis

IDP90147
(show subtarget assignments)

8

cloned

No

MPXV_ZAI1979_005_194

68449266

kelch-like protein [Monkeypox virus]

70

similar to CPXV-GRI-B19R, MPXV-ZAI96-B18R

Community Requests

2Q81

31.4%

Monkeypox virus

IDP01351
(show subtarget assignments)

1

cloned

No

VCA0387

15601150

toxin resistance protein

169

Conserved Gene / Pathway

Phase 2: March 2008

1YVO

31.4%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP00333
(show subtarget assignments)

1

crystallized

No

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01929
(show subtarget assignments)

1

cloned

No

lmo1076

16803116

hypothetical protein lmo1076 [Listeria m...

572

Known virulence-Invasion; Possible Vaccine Candidate; PMID:15009888

Phase 3: June 2008

3FI7

31.5%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01853
(show subtarget assignments)

1

cloned

No

CBU_1669

29542228

rpoS

RNA polymerase sigma factor RpoS [Coxiel...

352

Conserved; Drug target functions

Phase 3: June 2008

3IYD

31.5%

Coxiella burnetii

Transcription

Transcription factors

IDP91969
(show subtarget assignments)

8

selected

No

SpneCM_010100009453

298255801

peptidyl-prolyl cis-trans isomerase, cyc...

267

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2A2N

31.5%

Streptococcus pneumoniae

IDP91644
(show subtarget assignments)

8

purified

No

NP_215861

15608485

long-chain-fatty-acid--[acyl-carrier-pro...

521

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

3PBK

31.5%

Mycobacterium tuberculosis

IDP01356
(show subtarget assignments)

1

soluble

No

VC0010

15640042

amino acid ABC transporter, periplasmic ...

248

Conserved Gene / Pathway

Phase 2: March 2008

1GGG

31.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90688
(show subtarget assignments)

8

crystallized

No

Cj1595

15792900

rpoA

DNA-directed RNA polymerase subunit alph...

337

Predicted Essential

Community Requests

3IYD

31.5%

Campylobacter jejuni

IDP02452
(show subtarget assignments)

1

purified

No

GBAA3312

47528597

diaminobutyrate--2-oxoglutarate aminotra...

424

Conserved; Essential; Drug target functions

Phase 3: June 2008

2EH6

31.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP01060
(show subtarget assignments)

1

crystallized

No

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP90167
(show subtarget assignments)

8

purified

No

CD1838

123066836

Shikimate kinase

177

Potential drug target. Shikimate pathway enzyme

Community Requests

2PT5

31.6%

Clostridium difficile

IDP01006
(show subtarget assignments)

1

soluble

No

STM2529

16765849

putative anaerobic dimethylsulfoxide red...

209

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

31.6%

Salmonella enterica

Energy metabolism

Anaerobic