Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05293 (show subtarget assignments)	1	cloned	No	CD1408	126699011	ddl	D-alanine--D-alanine ligase [Clostridium...	299	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3R23	51.5%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02225 (show subtarget assignments)	1	cloned	No	CBU_1338	29541903		D-alanine--D-alanine ligase [Coxiella bu...	372	Conserved; Drug target functions	Phase 3: June 2008	3TQT	100%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04310 (show subtarget assignments)	1	cloned	No	BAS0231	49183264		D-alanine--D-alanine ligase, C-terminus ...	91	Proposed to be essential proteins	Phase 4: April 2009	2I80	54.9%	Bacillus anthracis

IDP01207 (show subtarget assignments)	1	in_pdb 3R5X 3R23	Yes	BA_2610	39930865		D-alanine--D-alanine ligase (D-alanylala...	304	Conserved Gene / Pathway	Phase 2: March 2008	3R23	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91787 (show subtarget assignments)	8	in_crystallization_trials	No	AAA24786	148325	vanC	D-alanine-D-alanine ligase-related prote...	343	drug resistance / D-Ala:D-Ser ligase	Community Requests	1E4E	39%	Enterococcus gallinarum

IDP01197 (show subtarget assignments)	0	work_stopped	No	BA_1389	81715334		D-alanine--poly(phosphoribitol) ligase s...	503	Conserved Gene / Pathway	Phase 2: March 2008	3DHV	99.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00620 (show subtarget assignments)	1	cloned	No	SACOL0937	57285812	dltC	D-alanine--poly(phosphoribitol) ligase s...	78	Conserved Gene / Pathway	Phase 2: March 2008	1DV5	41%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01103 (show subtarget assignments)	1	cloned	No	BA_1387	47605671		D-alanine--poly(phosphoribitol) ligase s...	79	Drug Target Function	Phase 2: March 2008	1DV5	45.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00919 (show subtarget assignments)	1	in_pdb 3Q1K 3I12	No	STM0380	16763760	ddl	D-alanyl-alanine synthetase A	364	Conserved Gene / Pathway	Phase 2: March 2008	3I12	100%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01488 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0572	15601331	ddl	D-alanyl-alanine synthetase A	334	Conserved Gene / Pathway	Phase 2: March 2008	2FB9	34.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90640 (show subtarget assignments)	8	cloned	No	Cj0798c	15792136	ddl	D-alanyl-alanine synthetase A [Campyloba...	346	Predicted Essential	Community Requests	2PVP	54%	Campylobacter jejuni

IDP00982 (show subtarget assignments)	1	soluble	No	STM2062	16765392	dacD	D-alanyl-D-alanine carboxypeptidase	390	Drug Target Function	Phase 2: March 2008	1NZO	45.1%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01487 (show subtarget assignments)	1	soluble	No	VCA0270	15601038		D-alanyl-D-alanine carboxypeptidase	389	Drug Target Function	Phase 2: March 2008	1NZO	44.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01407 (show subtarget assignments)	1	cloned	No	VC0947	15640963		D-alanyl-D-alanine carboxypeptidase	391	Drug Target Function	Phase 2: March 2008	1NZO	52.2%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01881 (show subtarget assignments)	1	cloned	No	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02523 (show subtarget assignments)	1	cloned	No	GBAA4297	47529591	dacF	D-alanyl-D-alanine carboxypeptidase [Bac...	396	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IT9	32.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00535 (show subtarget assignments)	1	purified	No	YPO3506	16123652	dacB	D-alanyl-D-alanine carboxypeptidase/endo...	482	Drug Target Function	Phase 2: March 2008	2EX2	77.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02767 (show subtarget assignments)	1	cloned	No	GBAA4750	47530050		D-alanyl-D-alanine carboxypeptidase fami...	259	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02666 (show subtarget assignments)	1	cloned	No	GBAA1490	47777937		D-alanyl-D-alanine carboxypeptidase fami...	374	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3MFD	44.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02154 (show subtarget assignments)	1	expressed	No	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02399 (show subtarget assignments)	1	cloned	No	GBAA2559	47527848		D-alanyl-D-alanine carboxypeptidase fami...	338	Drug target motif; Drug target functions	Phase 3: June 2008	1XP4	26.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01682 (show subtarget assignments)	1	cloned	No	GBAA5104	47530405		D-alanyl-D-alanine carboxypeptidase fami...	286	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02740 (show subtarget assignments)	1	expressed	No	GBAA1950	47527245		D-alanyl-D-alanine carboxypeptidase fami...	285	Drug target motif; Drug target functions	Phase 3: June 2008	3HUM	28.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02617 (show subtarget assignments)	1	expressed	No	GBAA1286	47526551		D-alanyl-D-alanine carboxypeptidase fami...	428	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3MFD	24.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01726 (show subtarget assignments)	1	cloned	No	GBAA5252	47530558		D-alanyl-D-alanine carboxypeptidase fami...	279	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	29.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02286 (show subtarget assignments)	1	cloned	No	FTT1029	56708118	dacD	D-alanyl-D-alanine carboxypeptidase (pen...	444	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IT9	31.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01885 (show subtarget assignments)	1	cloned	No	GBAA5639	47530965		D-alanyl-D-alanine carboxypeptidase, put...	423	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91977 (show subtarget assignments)	8	selected	No	SpneCM_010100007810	298255490		D-alanyl-D-alanine carboxypeptidase [Str...	238	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP02327 (show subtarget assignments)	1	expressed	No	YPO1320	16121602	dacC	D-alanyl-D-alanine carboxypeptidase [Yer...	432	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	3IT9	60.6%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01499 (show subtarget assignments)	1	cloned	No	VCA0870	15601625	pbpG	D-alanyl-D-alanine endopeptidase	316	Drug Target Function	Phase 2: March 2008	3IT9	27.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91445 (show subtarget assignments)	8	cloned	No	VV1_0414	27363882		D-amino acid dehydrogenase small subunit...	417	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1PJ5	18.5%	Vibrio vulnificus

IDP04146 (show subtarget assignments)	1	expressed	No	YPO2147	218929248	dadA	D-amino acid dehydrogenase small subunit...	434	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PJ5	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP91092 (show subtarget assignments)	8	soluble	No	A1S_1236	193076931		D-arabinose 5-phosphate isomerase [Acine...	325	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	32.9%	Acinetobacter baumannii

IDP90799 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3577	16123721		D-arabinose 5-phosphate isomerase [Yersi...	328	Predicted Essential	Community Requests	2XHZ	42.4%	Yersinia pestis

IDP00979 (show subtarget assignments)	1	purified	No	STM1953	16765291	yedO	D-cysteine desulfhydrase	328	Conserved Gene / Pathway	Phase 2: March 2008	1J0A	38.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP91871 (show subtarget assignments)	8	selected	No	AAB05624	1209528	vanYB	D,D-carboxypeptidase [Enterococcus faeca...	268	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests			Enterococcus faecalis

IDP91872 (show subtarget assignments)	8	selected	No	ACM47285	222159812	vanYD	D,D-carboxypeptidase VanYD [Enterococcus...	363	drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...	Community Requests	1ES4	24%	Enterococcus faecium

IDP91774 (show subtarget assignments)	8	in_pdb 4F78	No	AAQ16272	33355852	vanXYG	D,D-dipeptidase/D,D-carboxypeptidase [En...	254	drug resistance / D,D-dipeptidase/D,D-carboxypeptidase	Community Requests			Enterococcus faecalis

IDP91778 (show subtarget assignments)	8	in_crystallization_trials	No	AF132548_1	7380949	vanXYc	D,D-dipeptidase/D,D-carboxypeptidase Van...	190	drug resistance / Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) acti...	Community Requests			Enterococcus gallinarum

IDP91773 (show subtarget assignments)	8	purified	No	AAB05628	1209532	vanXB	D,D-dipeptidase [Enterococcus faecalis]	202	drug resistance / D,D-dipeptidase	Community Requests	1R44	74.8%	Enterococcus faecalis

IDP91776 (show subtarget assignments)	8	in_crystallization_trials	No	ACM47288	222159815	vanXD	D,D-dipeptidase VanXD [Enterococcus faec...	202	drug resistance / D,D-dipeptidase	Community Requests	1R44	70.3%	Enterococcus faecium

IDP02104 (show subtarget assignments)	1	soluble	No	YPO1074	16121375		D,D-heptose 1,7-bisphosphate phosphatase...	188	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2GMW	80.9%	Yersinia pestis	Unknown function	General

IDP01642 (show subtarget assignments)	1	cloned	No	Cj1150c	15792474	waaE	D,D-heptose 1-phosphate adenosyltransfer...	461	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	2AWD	15.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01860 (show subtarget assignments)	1	cloned	No	Cj1294	15792617		DegT family aminotransferase [Campylobac...	376	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	2FN6	44.7%	Campylobacter jejuni	Protein synthesis	tRNA aminoacylation

IDP91405 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_0801	27364250		dehydrogenase [Vibrio vulnificus CMCP6]	313	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3GDO	15%	Vibrio vulnificus

IDP00918 (show subtarget assignments)	1	soluble	No	STM0372	16763752	hemB	delta-aminolevulinic acid dehydratase	324	Conserved Gene / Pathway	Phase 2: March 2008	1I8J	93.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00745 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1715	57284726	hemB	delta-aminolevulinic acid dehydratase	324	Drug Target Function	Phase 2: March 2008	1B4E	47.8%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90713 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0995c	15792322	hemB	delta-aminolevulinic acid dehydratase [C...	327	Predicted Essential	Community Requests	1B4E	51.1%	Campylobacter jejuni

IDP05537 (show subtarget assignments)	1	cloned	No	CD3419	126701042	hemB	delta-aminolevulinic acid dehydratase [C...	321	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1W5Q	55.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90763 (show subtarget assignments)	8	in_crystallization_trials	No	VC0105	15640137		delta-aminolevulinic acid dehydratase [V...	347	Predicted Essential	Community Requests	1B4K	66.9%	Vibrio cholerae

IDP90791 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3771	16123907	hemB	delta-aminolevulinic acid dehydratase [Y...	340	Predicted Essential	Community Requests	1B4K	66.8%	Yersinia pestis

IDP04266 (show subtarget assignments)	1	cloned	No	CPF_2122	110798774	pdaA	delta-lactam-biosynthetic de-N-acetylase...	265	conserved gene; putative drug target function;	Phase 4: April 2009	2J13	41.5%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP90284 (show subtarget assignments)	8	expressed	No	TGME49_070250	211963365		dense granule protein 1 / major antigenp...	190	GRA1 is secreted from dense granule as one of the few soluble proteins that can ...	Community Requests			Toxoplasma gondii

IDP04299 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0840	15601595		deoxycytidylate deaminase, putative [Vib...	161	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W4L	32.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02591 (show subtarget assignments)	1	crystallized	No	YPO3383	16123532	dgt	deoxyguanosinetriphosphate triphosphohyd...	506	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2PGS	29.4%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP05086 (show subtarget assignments)	1	soluble	No	BA_0014	30253529		deoxynucleoside kinase family protein [B...	222	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2A2Z	29.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01090 (show subtarget assignments)	0	work_stopped	No	STM4567	16767808	deoC	deoxyribose-phosphate aldolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1JCL	94.3%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02132 (show subtarget assignments)	1	cloned	No	GBAA1892	47527187	dra	deoxyribose-phosphate aldolase [Bacillus...	223	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NGJ	57.8%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP90300 (show subtarget assignments)	8	in_pdb 4EIV 3QYQ	Yes	TGME49_118750	211967477		deoxyribose-phosphate aldolase, putative...	286	The deoxyribose phosphate aldolase-like gene TgPDA is recently described to be s...	Community Requests	3QYQ	96.5%	Toxoplasma gondii

IDP00907 (show subtarget assignments)	1	in_crystallization_trials	No	STM0140	16763530	coaE	dephospho-CoA kinase	206	Conserved Gene / Pathway	Phase 2: March 2008	1N3B	88.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00325 (show subtarget assignments)	1	crystallized	No	Cj1530	15792838	coaE	dephospho-CoA kinase	201	Drug Target Function	Phase 2: March 2008	2IF2	32.8%	Campylobacter jejuni	Unclassified	Unclassified

IDP00333 (show subtarget assignments)	1	crystallized	No	FTT1487	56708526	coaE	Dephospho-CoA kinase	204	Drug Target Function	Phase 2: March 2008	1JJV	31.4%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02800 (show subtarget assignments)	1	soluble	No	GBAA4828	47530124	coaE	dephospho-CoA kinase [Bacillus anthracis...	200	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JJV	43.5%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01835 (show subtarget assignments)	1	cloned	No	CBU_0152	29540772	coaE	dephospho-CoA kinase [Coxiella burnetii ...	199	Conserved; Drug target functions	Phase 3: June 2008	1JJV	45.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01044 (show subtarget assignments)	1	purified	No	STM3070	16766371	epd	D-erythrose 4-phosphate dehydrogenase	348	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	91.7%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP00501 (show subtarget assignments)	1	purified	No	YPO0922	16121227	epd	D-erythrose 4-phosphate dehydrogenase	338	Conserved Gene / Pathway	Phase 2: March 2008	2X5J	82.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP02289 (show subtarget assignments)	1	in_pdb 3OF5	No	FTT0934c	56708031	bioD	dethiobiotin synthetase [Francisella tul...	225	Conserved; Drug target functions	Phase 3: June 2008	3OF5	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90101 (show subtarget assignments)	8	in_crystallization_trials	No	STM2287	16765614	sseL	deubiquitinase [Salmonella typhimurium L...	317	SseL, is a ubiquitin isopeptidase that plays a critical role in the virulence an...	Community Requests			Salmonella enterica

IDP00693 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2145	57286359	glmS	D-fructose-6-phosphate amidotransferase ...	601	Drug Target Function	Phase 2: March 2008	1JXA	41.4%	Staphylococcus aureus	Central intermediary metabolism	Amino sugars

IDP00324 (show subtarget assignments)	1	cloned	No	Cj1366c	15792689	glmS	D-fructose-6-phosphate amidotransferase ...	598	Drug Target Function	Phase 2: March 2008	1JXA	41.3%	Campylobacter jejuni	Unclassified	Unclassified

IDP01677 (show subtarget assignments)	1	soluble	No	GBAA0159	47525416	glmS	D-fructose-6-phosphate amidotransferase ...	600	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1JXA	41.8%	Bacillus anthracis	Central intermediary metabolism	Amino sugars

IDP00524 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0490	16120820	apaH	diadenosine tetraphosphatase	289	Conserved Gene / Pathway	Phase 2: March 2008	2DFJ	73.7%	Yersinia pestis	Cellular processes	Adaptations to atypical conditions

IDP02706 (show subtarget assignments)	1	cloned	No	FTT0470	56707612	apaH	diadenosine tetraphosphatase [Francisell...	275	Drug Target	Phase 3: June 2008	2DFJ	37.8%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP02452 (show subtarget assignments)	1	purified	No	GBAA3312	47528597		diaminobutyrate--2-oxoglutarate aminotra...	424	Conserved; Essential; Drug target functions	Phase 3: June 2008	2EH6	31.6%	Bacillus anthracis	Central intermediary metabolism	Other

IDP00434 (show subtarget assignments)	1	cloned	No	YPO0796	16121108	lysA	diaminopimelate decarboxylase	420	Drug Target Function	Phase 2: March 2008	1KNW	76.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP90618 (show subtarget assignments)	8	purified	No	Cj0314	15791682	lysA	diaminopimelate decarboxylase [Campyloba...	402	Predicted Essential	Community Requests	2QGH	60.2%	Campylobacter jejuni

IDP90886 (show subtarget assignments)	8	in_pdb 3N2B	No	VC0125	15640156		diaminopimelate decarboxylase [Vibrio ch...	417	Predicted Essential	Community Requests	3N2B	100%	Vibrio cholerae

IDP00477 (show subtarget assignments)	1	purified	No	YPO3845	16123980	dapF	diaminopimelate epimerase	274	Conserved Gene / Pathway	Phase 2: March 2008	1GQZ	75.9%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02612 (show subtarget assignments)	0	work_stopped	No	GBAA5170	50196964	dapF	diaminopimelate epimerase [Bacillus anth...	288	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2OTN	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP90698 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1531	15792839	dapF	diaminopimelate epimerase [Campylobacter...	249	Predicted Essential	Community Requests	3EJX	30.2%	Campylobacter jejuni

IDP01701 (show subtarget assignments)	1	soluble	No	CBU_1970	29542525	dapF	diaminopimelate epimerase [Coxiella burn...	276	Conserved; Drug target functions	Phase 3: June 2008	1GQZ	48.9%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP91340 (show subtarget assignments)	8	cloned	No	VV2_0102	27366559		di- and tricarboxylate transporter [Vibr...	467	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP04598 (show subtarget assignments)	1	cloned	No	BAS1442	49184459		dihydrodipicolinate reductase [Bacillus ...	266	Proposed to be essential proteins	Phase 4: April 2009	1C3V	40.6%	Bacillus anthracis

IDP02541 (show subtarget assignments)	1	expressed	No	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP90532 (show subtarget assignments)	8	soluble	No	VC2391	15642388		dihydrodipicolinate reductase [Vibrio ch...	269	Predicted Essential	Community Requests	1ARZ	63.9%	Vibrio cholerae

IDP90934 (show subtarget assignments)	8	crystallized	No	YPO0480	16120810	dapB	dihydrodipicolinate reductase [Yersinia ...	273	Predicted Essential	Community Requests	1ARZ	79.5%	Yersinia pestis

IDP01004 (show subtarget assignments)	1	in_pdb 3G0S	Yes	STM2489	16765809	dapA	dihydrodipicolinate synthase	292	Conserved Gene / Pathway	Phase 2: March 2008	3G0S	100%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP02346 (show subtarget assignments)	1	cloned	No	GBAA2832	47528125	dapA-1	dihydrodipicolinate synthase [Bacillus a...	298	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NA8	34.2%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP90711 (show subtarget assignments)	8	in_pdb 3M5V 3LER	No	Cj0806	15792144	dapA	dihydrodipicolinate synthase [Campylobac...	298	Predicted Essential	Community Requests	3M5V	100%	Campylobacter jejuni

IDP01731 (show subtarget assignments)	1	expressed	No	CBU_1222	29541792	dapA	dihydrodipicolinate synthase [Coxiella b...	289	Conserved; Drug target functions	Phase 3: June 2008	3QZE	55.2%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP90663 (show subtarget assignments)	8	soluble	No	VC2157	15642156	dapA	dihydrodipicolinate synthase [Vibrio cho...	292	Predicted Essential	Community Requests	3G0S	59.6%	Vibrio cholerae

IDP02165 (show subtarget assignments)	1	soluble	No	CBU_1993	29542548	folA	dihydrofolate reductase [Coxiella burnet...	161	Conserved; Drug target functions	Phase 3: June 2008	3TQ8	100%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP04276 (show subtarget assignments)	1	soluble	No	FTT0312c	56707465	folA	dihydrofolate reductase type I [Francise...	166	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JW3	41.6%	Francisella tularensis

IDP90885 (show subtarget assignments)	8	purified	No	VC0440	15640467		dihydrofolate reductase [Vibrio cholerae...	165	Predicted Essential	Community Requests	3IA4	52.7%	Vibrio cholerae

IDP90544 (show subtarget assignments)	8	in_pdb 3Q1H	Yes	YPO0486	16120816	folA	dihydrofolate reductase [Yersinia pestis...	160	Predicted Essential	Community Requests	3Q1H	100%	Yersinia pestis

IDP02596 (show subtarget assignments)	1	cloned	No	GBAA1269	47526536	odhB	dihydrolipoamide acetyltransferase [Baci...	418	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DUF	38.1%	Bacillus anthracis	Energy metabolism	TCA cycle

IDP02812 (show subtarget assignments)	1	cloned	No	FTT1484c	56708523	aceF	dihydrolipoamide acetyltransferase [Fran...	631	Conserved; Drug target functions	Phase 3: June 2008	3DUF	26%	Francisella tularensis	Energy metabolism	Pyruvate dehydrogenase

IDP00740 (show subtarget assignments)	1	cloned	No	SACOL1105	57285891	pdhD	dihydrolipoamide dehydrogenase	468	Drug Target Function	Phase 2: March 2008	1EBD	70.9%	Staphylococcus aureus	Energy metabolism	Pyruvate dehydrogenase

IDP02696 (show subtarget assignments)	1	soluble	No	GBAA2773	47528064	acoL	dihydrolipoamide dehydrogenase [Bacillus...	459	Conserved; Drug target functions	Phase 3: June 2008	2QAE	40.6%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02321 (show subtarget assignments)	1	cloned	No	FTT0077	56707256	sucB	dihydrolipoamide succinyltransferase com...	489	Conserved; Drug target functions	Phase 3: June 2008	1C4T	29.9%	Francisella tularensis	Energy metabolism	TCA cycle

IDP05293
(show subtarget assignments)

1

cloned

No

CD1408

126699011

ddl

D-alanine--D-alanine ligase [Clostridium...

299

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3R23

51.5%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02225
(show subtarget assignments)

1

cloned

No

CBU_1338

29541903

D-alanine--D-alanine ligase [Coxiella bu...

372

Conserved; Drug target functions

Phase 3: June 2008

3TQT

100%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04310
(show subtarget assignments)

1

cloned

No

BAS0231

49183264

D-alanine--D-alanine ligase, C-terminus ...

91

Proposed to be essential proteins

Phase 4: April 2009

2I80

54.9%

Bacillus anthracis

IDP01207
(show subtarget assignments)

1

in_pdb
3R5X
3R23

Yes

BA_2610

39930865

D-alanine--D-alanine ligase (D-alanylala...

304

Conserved Gene / Pathway

Phase 2: March 2008

3R23

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91787
(show subtarget assignments)

8

in_crystallization_trials

No

AAA24786

148325

vanC

D-alanine-D-alanine ligase-related prote...

343

drug resistance / D-Ala:D-Ser ligase

Community Requests

1E4E

39%

Enterococcus gallinarum

IDP01197
(show subtarget assignments)

0

work_stopped

No

BA_1389

81715334

D-alanine--poly(phosphoribitol) ligase s...

503

Conserved Gene / Pathway

Phase 2: March 2008

3DHV

99.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00620
(show subtarget assignments)

1

cloned

No

SACOL0937

57285812

dltC

D-alanine--poly(phosphoribitol) ligase s...

78

Conserved Gene / Pathway

Phase 2: March 2008

1DV5

41%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01103
(show subtarget assignments)

1

cloned

No

BA_1387

47605671

D-alanine--poly(phosphoribitol) ligase s...

79

Drug Target Function

Phase 2: March 2008

1DV5

45.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00919
(show subtarget assignments)

1

in_pdb
3Q1K
3I12

No

STM0380

16763760

ddl

D-alanyl-alanine synthetase A

364

Conserved Gene / Pathway

Phase 2: March 2008

3I12

100%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01488
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0572

15601331

ddl

D-alanyl-alanine synthetase A

334

Conserved Gene / Pathway

Phase 2: March 2008

2FB9

34.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90640
(show subtarget assignments)

8

cloned

No

Cj0798c

15792136

ddl

D-alanyl-alanine synthetase A [Campyloba...

346

Predicted Essential

Community Requests

2PVP

54%

Campylobacter jejuni

IDP00982
(show subtarget assignments)

1

soluble

No

STM2062

16765392

dacD

D-alanyl-D-alanine carboxypeptidase

390

Drug Target Function

Phase 2: March 2008

1NZO

45.1%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01487
(show subtarget assignments)

1

soluble

No

VCA0270

15601038

D-alanyl-D-alanine carboxypeptidase

389

Drug Target Function

Phase 2: March 2008

1NZO

44.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01407
(show subtarget assignments)

1

cloned

No

VC0947

15640963

D-alanyl-D-alanine carboxypeptidase

391

Drug Target Function

Phase 2: March 2008

1NZO

52.2%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01881
(show subtarget assignments)

1

cloned

No

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02523
(show subtarget assignments)

1

cloned

No

GBAA4297

47529591

dacF

D-alanyl-D-alanine carboxypeptidase [Bac...

396

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IT9

32.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00535
(show subtarget assignments)

1

purified

No

YPO3506

16123652

dacB

D-alanyl-D-alanine carboxypeptidase/endo...

482

Drug Target Function

Phase 2: March 2008

2EX2

77.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02767
(show subtarget assignments)

1

cloned

No

GBAA4750

47530050

D-alanyl-D-alanine carboxypeptidase fami...

259

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02666
(show subtarget assignments)

1

cloned

No

GBAA1490

47777937

D-alanyl-D-alanine carboxypeptidase fami...

374

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3MFD

44.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02154
(show subtarget assignments)

1

expressed

No

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02399
(show subtarget assignments)

1

cloned

No

GBAA2559

47527848

D-alanyl-D-alanine carboxypeptidase fami...

338

Drug target motif; Drug target functions

Phase 3: June 2008

1XP4

26.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01682
(show subtarget assignments)

1

cloned

No

GBAA5104

47530405

D-alanyl-D-alanine carboxypeptidase fami...

286

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02740
(show subtarget assignments)

1

expressed

No

GBAA1950

47527245

D-alanyl-D-alanine carboxypeptidase fami...

285

Drug target motif; Drug target functions

Phase 3: June 2008

3HUM

28.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02617
(show subtarget assignments)

1

expressed

No

GBAA1286

47526551

D-alanyl-D-alanine carboxypeptidase fami...

428

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3MFD

24.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01726
(show subtarget assignments)

1

cloned

No

GBAA5252

47530558

D-alanyl-D-alanine carboxypeptidase fami...

279

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

29.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02286
(show subtarget assignments)

1

cloned

No

FTT1029

56708118

dacD

D-alanyl-D-alanine carboxypeptidase (pen...

444

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IT9

31.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01885
(show subtarget assignments)

1

cloned

No

GBAA5639

47530965

D-alanyl-D-alanine carboxypeptidase, put...

423

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91977
(show subtarget assignments)

8

selected

No

SpneCM_010100007810

298255490

D-alanyl-D-alanine carboxypeptidase [Str...

238

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP02327
(show subtarget assignments)

1

expressed

No

YPO1320

16121602

dacC

D-alanyl-D-alanine carboxypeptidase [Yer...

432

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

3IT9

60.6%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01499
(show subtarget assignments)

1

cloned

No

VCA0870

15601625

pbpG

D-alanyl-D-alanine endopeptidase

316

Drug Target Function

Phase 2: March 2008

3IT9

27.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91445
(show subtarget assignments)

8

cloned

No

VV1_0414

27363882

D-amino acid dehydrogenase small subunit...

417

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1PJ5

18.5%

Vibrio vulnificus

IDP04146
(show subtarget assignments)

1

expressed

No

YPO2147

218929248

dadA

D-amino acid dehydrogenase small subunit...

434

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PJ5

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP91092
(show subtarget assignments)

8

soluble

No

A1S_1236

193076931

D-arabinose 5-phosphate isomerase [Acine...

325

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

32.9%

Acinetobacter baumannii

IDP90799
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3577

16123721

D-arabinose 5-phosphate isomerase [Yersi...

328

Predicted Essential

Community Requests

2XHZ

42.4%

Yersinia pestis

IDP00979
(show subtarget assignments)

1

purified

No

STM1953

16765291

yedO

D-cysteine desulfhydrase

328

Conserved Gene / Pathway

Phase 2: March 2008

1J0A

38.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP91871
(show subtarget assignments)

8

selected

No

AAB05624

1209528

vanYB

D,D-carboxypeptidase [Enterococcus faeca...

268

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

Enterococcus faecalis

IDP91872
(show subtarget assignments)

8

selected

No

ACM47285

222159812

vanYD

D,D-carboxypeptidase VanYD [Enterococcus...

363

drug resistance / confers resistance to vancomycin/teicoplanin by hydrolyzing normal cell wall pre...

Community Requests

1ES4

24%

Enterococcus faecium

IDP91774
(show subtarget assignments)

8

in_pdb
4F78

No

AAQ16272

33355852

vanXYG

D,D-dipeptidase/D,D-carboxypeptidase [En...

254

drug resistance / D,D-dipeptidase/D,D-carboxypeptidase

Community Requests

Enterococcus faecalis

IDP91778
(show subtarget assignments)

8

in_crystallization_trials

No

AF132548_1

7380949

vanXYc

D,D-dipeptidase/D,D-carboxypeptidase Van...

190

drug resistance / Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) acti...

Community Requests

Enterococcus gallinarum

IDP91773
(show subtarget assignments)

8

purified

No

AAB05628

1209532

vanXB

D,D-dipeptidase [Enterococcus faecalis]

202

drug resistance / D,D-dipeptidase

Community Requests

1R44

74.8%

Enterococcus faecalis

IDP91776
(show subtarget assignments)

8

in_crystallization_trials

No

ACM47288

222159815

vanXD

D,D-dipeptidase VanXD [Enterococcus faec...

202

drug resistance / D,D-dipeptidase

Community Requests

1R44

70.3%

Enterococcus faecium

IDP02104
(show subtarget assignments)

1

soluble

No

YPO1074

16121375

D,D-heptose 1,7-bisphosphate phosphatase...

188

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2GMW

80.9%

Yersinia pestis

Unknown function

General

IDP01642
(show subtarget assignments)

1

cloned

No

Cj1150c

15792474

waaE

D,D-heptose 1-phosphate adenosyltransfer...

461

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

2AWD

15.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01860
(show subtarget assignments)

1

cloned

No

Cj1294

15792617

DegT family aminotransferase [Campylobac...

376

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

2FN6

44.7%

Campylobacter jejuni

Protein synthesis

tRNA aminoacylation

IDP91405
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_0801

27364250

dehydrogenase [Vibrio vulnificus CMCP6]

313

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3GDO

15%

Vibrio vulnificus

IDP00918
(show subtarget assignments)

1

soluble

No

STM0372

16763752

hemB

delta-aminolevulinic acid dehydratase

324

Conserved Gene / Pathway

Phase 2: March 2008

1I8J

93.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00745
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1715

57284726

hemB

delta-aminolevulinic acid dehydratase

324

Drug Target Function

Phase 2: March 2008

1B4E

47.8%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90713
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0995c

15792322

hemB

delta-aminolevulinic acid dehydratase [C...

327

Predicted Essential

Community Requests

1B4E

51.1%

Campylobacter jejuni

IDP05537
(show subtarget assignments)

1

cloned

No

CD3419

126701042

hemB

delta-aminolevulinic acid dehydratase [C...

321

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1W5Q

55.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP90763
(show subtarget assignments)

8

in_crystallization_trials

No

VC0105

15640137

delta-aminolevulinic acid dehydratase [V...

347

Predicted Essential

Community Requests

1B4K

66.9%

Vibrio cholerae

IDP90791
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3771

16123907

hemB

delta-aminolevulinic acid dehydratase [Y...

340

Predicted Essential

Community Requests

1B4K

66.8%

Yersinia pestis

IDP04266
(show subtarget assignments)

1

cloned

No

CPF_2122

110798774

pdaA

delta-lactam-biosynthetic de-N-acetylase...

265

conserved gene; putative drug target function;

Phase 4: April 2009

2J13

41.5%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP90284
(show subtarget assignments)

8

expressed

No

TGME49_070250

211963365

dense granule protein 1 / major antigenp...

190

GRA1 is secreted from dense granule as one of the few soluble proteins that can ...

Community Requests

Toxoplasma gondii

IDP04299
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0840

15601595

deoxycytidylate deaminase, putative [Vib...

161

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W4L

32.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02591
(show subtarget assignments)

1

crystallized

No

YPO3383

16123532

dgt

deoxyguanosinetriphosphate triphosphohyd...

506

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2PGS

29.4%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP05086
(show subtarget assignments)

1

soluble

No

BA_0014

30253529

deoxynucleoside kinase family protein [B...

222

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2A2Z

29.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01090
(show subtarget assignments)

0

work_stopped

No

STM4567

16767808

deoC

deoxyribose-phosphate aldolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1JCL

94.3%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02132
(show subtarget assignments)

1

cloned

No

GBAA1892

47527187

dra

deoxyribose-phosphate aldolase [Bacillus...

223

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NGJ

57.8%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP90300
(show subtarget assignments)

8

in_pdb
4EIV
3QYQ

Yes

TGME49_118750

211967477

deoxyribose-phosphate aldolase, putative...

286

The deoxyribose phosphate aldolase-like gene TgPDA is recently described to be s...

Community Requests

3QYQ

96.5%

Toxoplasma gondii

IDP00907
(show subtarget assignments)

1

in_crystallization_trials

No

STM0140

16763530

coaE

dephospho-CoA kinase

206

Conserved Gene / Pathway

Phase 2: March 2008

1N3B

88.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00325
(show subtarget assignments)

1

crystallized

No

Cj1530

15792838

coaE

dephospho-CoA kinase

201

Drug Target Function

Phase 2: March 2008

2IF2

32.8%

Campylobacter jejuni

Unclassified

IDP00333
(show subtarget assignments)

1

crystallized

No

FTT1487

56708526

coaE

Dephospho-CoA kinase

204

Drug Target Function

Phase 2: March 2008

1JJV

31.4%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02800
(show subtarget assignments)

1

soluble

No

GBAA4828

47530124

coaE

dephospho-CoA kinase [Bacillus anthracis...

200

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JJV

43.5%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01835
(show subtarget assignments)

1

cloned

No

CBU_0152

29540772

coaE

dephospho-CoA kinase [Coxiella burnetii ...

199

Conserved; Drug target functions

Phase 3: June 2008

1JJV

45.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01044
(show subtarget assignments)

1

purified

No

STM3070

16766371

epd

D-erythrose 4-phosphate dehydrogenase

348

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

91.7%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP00501
(show subtarget assignments)

1

purified

No

YPO0922

16121227

epd

D-erythrose 4-phosphate dehydrogenase

338

Conserved Gene / Pathway

Phase 2: March 2008

2X5J

82.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP02289
(show subtarget assignments)

1

in_pdb
3OF5

No

FTT0934c

56708031

bioD

dethiobiotin synthetase [Francisella tul...

225

Conserved; Drug target functions

Phase 3: June 2008

3OF5

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90101
(show subtarget assignments)

8

in_crystallization_trials

No

STM2287

16765614

sseL

deubiquitinase [Salmonella typhimurium L...

317

SseL, is a ubiquitin isopeptidase that plays a critical role in the virulence an...

Community Requests

Salmonella enterica

IDP00693
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2145

57286359

glmS

D-fructose-6-phosphate amidotransferase ...

601

Drug Target Function

Phase 2: March 2008

1JXA

41.4%

Staphylococcus aureus

Central intermediary metabolism

Amino sugars

IDP00324
(show subtarget assignments)

1

cloned

No

Cj1366c

15792689

glmS

D-fructose-6-phosphate amidotransferase ...

598

Drug Target Function

Phase 2: March 2008

1JXA

41.3%

Campylobacter jejuni

Unclassified

IDP01677
(show subtarget assignments)

1

soluble

No

GBAA0159

47525416

glmS

D-fructose-6-phosphate amidotransferase ...

600

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1JXA

41.8%

Bacillus anthracis

Central intermediary metabolism

Amino sugars

IDP00524
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0490

16120820

apaH

diadenosine tetraphosphatase

289

Conserved Gene / Pathway

Phase 2: March 2008

2DFJ

73.7%

Yersinia pestis

Cellular processes

Adaptations to atypical conditions

IDP02706
(show subtarget assignments)

1

cloned

No

FTT0470

56707612

apaH

diadenosine tetraphosphatase [Francisell...

275

Drug Target

Phase 3: June 2008

2DFJ

37.8%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP02452
(show subtarget assignments)

1

purified

No

GBAA3312

47528597

diaminobutyrate--2-oxoglutarate aminotra...

424

Conserved; Essential; Drug target functions

Phase 3: June 2008

2EH6

31.6%

Bacillus anthracis

Central intermediary metabolism

Other

IDP00434
(show subtarget assignments)

1

cloned

No

YPO0796

16121108

lysA

diaminopimelate decarboxylase

420

Drug Target Function

Phase 2: March 2008

1KNW

76.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP90618
(show subtarget assignments)

8

purified

No

Cj0314

15791682

lysA

diaminopimelate decarboxylase [Campyloba...

402

Predicted Essential

Community Requests

2QGH

60.2%

Campylobacter jejuni

IDP90886
(show subtarget assignments)

8

in_pdb
3N2B

No

VC0125

15640156

diaminopimelate decarboxylase [Vibrio ch...

417

Predicted Essential

Community Requests

3N2B

100%

Vibrio cholerae

IDP00477
(show subtarget assignments)

1

purified

No

YPO3845

16123980

dapF

diaminopimelate epimerase

274

Conserved Gene / Pathway

Phase 2: March 2008

1GQZ

75.9%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02612
(show subtarget assignments)

0

work_stopped

No

GBAA5170

50196964

dapF

diaminopimelate epimerase [Bacillus anth...

288

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2OTN

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP90698
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1531

15792839

dapF

diaminopimelate epimerase [Campylobacter...

249

Predicted Essential

Community Requests

3EJX

30.2%

Campylobacter jejuni

IDP01701
(show subtarget assignments)

1

soluble

No

CBU_1970

29542525

dapF

diaminopimelate epimerase [Coxiella burn...

276

Conserved; Drug target functions

Phase 3: June 2008

1GQZ

48.9%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP91340
(show subtarget assignments)

8

cloned

No

VV2_0102

27366559

di- and tricarboxylate transporter [Vibr...

467

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP04598
(show subtarget assignments)

1

cloned

No

BAS1442

49184459

dihydrodipicolinate reductase [Bacillus ...

266

Proposed to be essential proteins

Phase 4: April 2009

1C3V

40.6%

Bacillus anthracis

IDP02541
(show subtarget assignments)

1

expressed

No

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP90532
(show subtarget assignments)

8

soluble

No

VC2391

15642388

dihydrodipicolinate reductase [Vibrio ch...

269

Predicted Essential

Community Requests

1ARZ

63.9%

Vibrio cholerae

IDP90934
(show subtarget assignments)

8

crystallized

No

YPO0480

16120810

dapB

dihydrodipicolinate reductase [Yersinia ...

273

Predicted Essential

Community Requests

1ARZ

79.5%

Yersinia pestis

IDP01004
(show subtarget assignments)

1

in_pdb
3G0S

Yes

STM2489

16765809

dapA

dihydrodipicolinate synthase

292

Conserved Gene / Pathway

Phase 2: March 2008

3G0S

100%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP02346
(show subtarget assignments)

1

cloned

No

GBAA2832

47528125

dapA-1

dihydrodipicolinate synthase [Bacillus a...

298

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NA8

34.2%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP90711
(show subtarget assignments)

8

in_pdb
3M5V
3LER

No

Cj0806

15792144

dapA

dihydrodipicolinate synthase [Campylobac...

298

Predicted Essential

Community Requests

3M5V

100%

Campylobacter jejuni

IDP01731
(show subtarget assignments)

1

expressed

No

CBU_1222

29541792

dapA

dihydrodipicolinate synthase [Coxiella b...

289

Conserved; Drug target functions

Phase 3: June 2008

3QZE

55.2%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP90663
(show subtarget assignments)

8

soluble

No

VC2157

15642156

dapA

dihydrodipicolinate synthase [Vibrio cho...

292

Predicted Essential

Community Requests

3G0S

59.6%

Vibrio cholerae

IDP02165
(show subtarget assignments)

1

soluble

No

CBU_1993

29542548

folA

dihydrofolate reductase [Coxiella burnet...

161

Conserved; Drug target functions

Phase 3: June 2008

3TQ8

100%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP04276
(show subtarget assignments)

1

soluble

No

FTT0312c

56707465

folA

dihydrofolate reductase type I [Francise...

166

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JW3

41.6%

Francisella tularensis

IDP90885
(show subtarget assignments)

8

purified

No

VC0440

15640467

dihydrofolate reductase [Vibrio cholerae...

165

Predicted Essential

Community Requests

3IA4

52.7%

Vibrio cholerae

IDP90544
(show subtarget assignments)

8

in_pdb
3Q1H

Yes

YPO0486

16120816

folA

dihydrofolate reductase [Yersinia pestis...

160

Predicted Essential

Community Requests

3Q1H

100%

Yersinia pestis

IDP02596
(show subtarget assignments)

1

cloned

No

GBAA1269

47526536

odhB

dihydrolipoamide acetyltransferase [Baci...

418

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DUF

38.1%

Bacillus anthracis

Energy metabolism

TCA cycle

IDP02812
(show subtarget assignments)

1

cloned

No

FTT1484c

56708523

aceF

dihydrolipoamide acetyltransferase [Fran...

631

Conserved; Drug target functions

Phase 3: June 2008

3DUF

26%

Francisella tularensis

Energy metabolism

Pyruvate dehydrogenase

IDP00740
(show subtarget assignments)

1

cloned

No

SACOL1105

57285891

pdhD

dihydrolipoamide dehydrogenase

468

Drug Target Function

Phase 2: March 2008

1EBD

70.9%

Staphylococcus aureus

Energy metabolism

Pyruvate dehydrogenase

IDP02696
(show subtarget assignments)

1

soluble

No

GBAA2773

47528064

acoL

dihydrolipoamide dehydrogenase [Bacillus...

459

Conserved; Drug target functions

Phase 3: June 2008

2QAE

40.6%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02321
(show subtarget assignments)

1

cloned

No

FTT0077

56707256

sucB

dihydrolipoamide succinyltransferase com...

489

Conserved; Drug target functions

Phase 3: June 2008

1C4T

29.9%

Francisella tularensis

Energy metabolism

TCA cycle