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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 15 of 60, showing 100 records out of 5973 total, starting on record 1401
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP00129
(
show subtarget assignments
)
0
work_stopped
No
NT01ST3985
16766479
mdaB
NADPH-specific quinone oxidoreductase
193
Virulence
Phase 1: October 2007
2AMJ
91.7%
Salmonella enterica
Cellular processes
Toxin production and resistance
IDP01152
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_5520
30259980
mbl
mbl protein
333
Conserved Gene / Pathway
Phase 2: March 2008
1JCE
50.5%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP91707
(
show subtarget assignments
)
8
selected
No
NP_005447
4885433
MAPK8IP1
C-Jun-amino-terminal kinase-interacting ...
711
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2FPF
9.8%
Homo sapiens
IDP90949
(
show subtarget assignments
)
8
purified
No
ZZZ_0019
20986512
MAPK14
mitogen-activated protein kinase 14 isof...
360
Drug Target
Community Requests
1A9U
100%
Homo sapiens
IDP90950
(
show subtarget assignments
)
8
soluble
No
ZZZ_0018
51094326
MAPK-1
mitogen-activated protein kinase 1
532
Drug Target Homolog
Community Requests
3OHT
30.1%
Toxoplasma gondii
IDP05297
(
show subtarget assignments
)
1
cloned
No
CD2188
126699804
mapA
maltose phosphorylase [Clostridium diffi...
761
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1H54
51.9%
Clostridium difficile
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP91729
(
show subtarget assignments
)
8
selected
No
NP_660186
21735544
MAP2K7
dual specificity mitogen-activated prote...
419
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2DYL
72.3%
Homo sapiens
IDP02686
(
show subtarget assignments
)
1
soluble
No
FTT0393
56707542
map
methionine aminopeptidase [Francisella t...
256
Conserved; Drug target functions; Drug target motif
Community Interest
1C21
59.4%
Francisella tularensis
N/A
N/A
IDP04144
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3337
218930358
map
methionine aminopeptidase [Yersinia pest...
261
drug target; virulence factor; putative drug target function;
Community Interest
1C21
55.2%
Yersinia pestis
Protein fate
Protein modification and repair
IDP02071
(
show subtarget assignments
)
1
expressed
No
CBU_1388
29541953
map
methionine aminopeptidase, type I [Coxie...
258
Conserved; Drug target functions
Community Interest
1MAT
65.1%
Coxiella burnetii
Protein fate
Protein modification and repair
IDP00482
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1758
16122014
manX
PTS system, mannose-specific IIAB compon...
324
Virulence Associated Factor
Phase 2: March 2008
2JZH
45.4%
Yersinia pestis
Amino acid biosynthesis
Aromatic amino acid family
IDP02243
(
show subtarget assignments
)
1
cloned
No
YPO0834
16121142
manX
putative PTS transport protein [Yersinia...
165
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
3EYE
41.8%
Yersinia pestis
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP04290
(
show subtarget assignments
)
1
cloned
No
YPO3099
218930141
manC
mannose-1-phosphate guanylyltransferase ...
470
virulence factor; conserved gene; putative drug target function;
Phase 4: April 2009
2CU2
28.1%
Yersinia pestis
Purines, pyrimidines, nucleosides, and nucleotides
IDP02419
(
show subtarget assignments
)
1
purified
No
FTT1447c
56708489
manB
phosphomannomutase [Francisella tularens...
494
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
2F7L
25.7%
Francisella tularensis
Unclassified
Role category not yet assigned
IDP04472
(
show subtarget assignments
)
1
selected
No
YPO2479
115348179
manB
phosphomannomutase [Yersinia pestis CO92...
462
drug target; putative drug target function;
Phase 4: April 2009
3UW2
35.6%
Yersinia pestis
Energy metabolism
Sugars
IDP04373
(
show subtarget assignments
)
1
cloned
No
YPO3097
218930139
manB
phosphomannomutase [Yersinia pestis CO92...
457
drug target; virulence factor; putative drug target function;
Phase 4: April 2009
3UW2
37.8%
Yersinia pestis
Energy metabolism
Sugars
IDP01869
(
show subtarget assignments
)
1
purified
No
STM1467
16764813
manA
mannose-6-phosphate isomerase [Salmonell...
391
Conserved; Drug target functions
Phase 3: June 2008
2WFP
100%
Salmonella enterica
Energy metabolism
Sugars
IDP02539
(
show subtarget assignments
)
1
cloned
No
YPO3200
16123361
malZ
maltodextrin glucosidase [Yersinia pesti...
609
Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...
Phase 3: June 2008
1EA9
33.5%
Yersinia pestis
Energy metabolism
Biosynthesis and degradation of polysaccharides
IDP02091
(
show subtarget assignments
)
1
expressed
No
STM3515
16766803
malT
transcriptional regulator MalT [Salmonel...
901
Conserved; Drug target functions
Phase 3: June 2008
1HZ4
36.6%
Salmonella enterica
Energy metabolism
Other
IDP90338
(
show subtarget assignments
)
8
cloned
No
CT087
15604806
malQ
4-alpha-glucanotransferase [Chlamydia tr...
527
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2X1I
25.2%
Chlamydia trachomatis
IDP05058
(
show subtarget assignments
)
1
in_crystallization_trials
No
CD0468
126698044
malL
oligo-1,6-glucosidase [Clostridium diffi...
554
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2ZE0
44%
Clostridium difficile
Energy metabolism: Sugars
IDP91515
(
show subtarget assignments
)
8
cloned
No
VV2_1587
27367932
malG
maltose transporter permease [Vibrio vul...
296
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2R6G
82.4%
Vibrio vulnificus
IDP01500
(
show subtarget assignments
)
1
in_crystallization_trials
No
VCA0945
15601698
malE
maltose ABC transporter periplasmic prot...
406
Conserved Gene / Pathway
Phase 2: March 2008
3JYR
65%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP91715
(
show subtarget assignments
)
8
selected
No
NP_008917
52632377
MAGED1
melanoma-associated antigen D1 isoform b...
778
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3NW0
12.1%
Homo sapiens
IDP04301
(
show subtarget assignments
)
1
soluble
No
CPF_2400
110800698
maf
Maf-like protein [Clostridium perfringen...
192
conserved gene; putative drug target function;
Phase 4: April 2009
2P5X
44.4%
Clostridium perfringens
Cellular processes
Cell division
IDP01055
(
show subtarget assignments
)
1
crystallized
No
STM3371
16766666
maf
Maf-like protein
197
Conserved Gene / Pathway
Phase 2: March 2008
1EX2
43.7%
Salmonella enterica
Cellular processes
Cell division
IDP00954
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1189
16764544
maf
Maf-like protein
194
Essential Gene
Phase 2: March 2008
1EX2
31.4%
Salmonella enterica
Cellular processes
Cell division
IDP91354
(
show subtarget assignments
)
8
cloned
No
VV1_3015
27366287
maf
Maf-like protein [Vibrio vulnificus CMCP...
194
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2P5X
29.4%
Vibrio vulnificus
IDP02831
(
show subtarget assignments
)
1
crystallized
No
GBAA4686
47529986
maf
Maf-like protein [Bacillus anthracis str...
191
Conserved; Drug target functions
Phase 3: June 2008
1EX2
53.4%
Bacillus anthracis
Cellular processes
Cell division
IDP01327
(
show subtarget assignments
)
1
purified
No
VC0418
15640445
maf
Maf-like protein
205
Conserved Gene / Pathway
Phase 2: March 2008
1EX2
40%
Vibrio cholerae
Cellular processes
Cell division
IDP91816
(
show subtarget assignments
)
8
cloned
No
b2463
1788806
maeB
fused malic enzyme predicted oxidoreduct...
759
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1WW8
26.5%
Escherichia coli
IDP01873
(
show subtarget assignments
)
1
cloned
No
FTT0917
56708018
maeA
malate dehydrogenase [Francisella tulare...
604
Drug Target
Phase 3: June 2008
2AW5
34.8%
Francisella tularensis
Unknown function
Enzymes of unknown specificity
IDP02453
(
show subtarget assignments
)
1
in_pdb
3IGJ
3HJJ
No
GBAA3402
47528687
maA
maltose O-acetyltransferase [Bacillus an...
187
Drug target motif; Conserved; Essential; Drug target functions
Phase 3: June 2008
3HJJ
100%
Bacillus anthracis
Cellular processes
Detoxification
IDP05262
(
show subtarget assignments
)
1
in_pdb
4EBH
3SRT
No
CD0872
126698449
maa
maltose O-acetyltransferase [Clostridium...
185
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3SRT
100%
Clostridium difficile
Cellular processes: Detoxification
IDP04551
(
show subtarget assignments
)
1
cloned
No
CPF_2912
110800993
maa
maltose transacetylase [Clostridium perf...
195
conserved gene; putative drug target function;
Phase 4: April 2009
1OCX
64.6%
Clostridium perfringens
Cellular processes
Detoxification
IDP90081
(
show subtarget assignments
)
8
cloned
No
ABD79034.1
89892477
M2
matrix protein 2 [Influenza A virus (A/U...
96
Influenza matrix protein 2 (M2) is a validated therapeutic target whose on-marke...
Community Requests
2L0J
42.7%
Influenza A
IDP90221
(
show subtarget assignments
)
8
cloned
No
MYXV_gp157
9633790
m154L
m154L, gp120-like
214
NFkB inhibitor, similar to VACV-Cop:M2L
Community Requests
Myxoma virus
host defense modulator
0
IDP90220
(
show subtarget assignments
)
8
selected
No
MYXV_gp153
9633785
m150R
m150R
494
ankyrin-like protein, myxoma nuclear factor
Community Requests
Myxoma virus
host range factor
0
IDP90207
(
show subtarget assignments
)
8
soluble
No
MYXV_gp152
9633784
m149R
m149R
490
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
1N11
14.9%
Myxoma virus
host range factor
0
IDP90218
(
show subtarget assignments
)
8
soluble
No
MYXV_gp151
9633783
m148R
m148R
675
ankyrin motif, similar to VACV-Cop:B4R
Community Requests
2J8S
6.1%
Myxoma virus
host range factor
0
IDP90206
(
show subtarget assignments
)
8
soluble
No
MYXV_gp149
9633781
m146R
m146R
108
virokine/NFkB inh/Str resemblence to apoptotic reg, similar to VACV-Cop:N1L
Community Requests
2I39
26.9%
Myxoma virus
host defense modulator
0
IDP90209
(
show subtarget assignments
)
8
expressed
No
MYXV_gp144
9633776
m140R
m140R
553
kelch motif, similar to VACV-Cop:A55R
Community Requests
1U6D
14.3%
Myxoma virus
unknown, conserved protein
0
IDP90208
(
show subtarget assignments
)
8
expressed
No
MYXV_gp143
9633775
m139R
m139R
188
Intracellular TLR and IL-1 signaling inhibitor, similar to VACV-Cop:A52R
Community Requests
2VVW
32.4%
Myxoma virus
host defense modulator
0
IDP90210
(
show subtarget assignments
)
8
expressed
No
MYXV_gp140
9633772
m136R
m136R
179
unknown, similar to VACV-Cop:A52R
Community Requests
2VVW
20.1%
Myxoma virus
unknown, conserved protein
0
IDP90211
(
show subtarget assignments
)
8
cloned
No
MYXV_gp132
9633764
m128L
m128L
281
integrin-associated protein homolog similar to VACV-Cop:A38L. Five pass TM prote...
Community Requests
Myxoma virus
host defense modulator
0
IDP91677
(
show subtarget assignments
)
8
selected
No
FLUAVs7gp1
8486123
M1
matrix protein 1 [Influenza A virus (A/P...
252
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1EA3
65.1%
Influenza A
IDP90212
(
show subtarget assignments
)
8
cloned
No
MYXV_gp067
9633699
m063R
m063R, m63R
215
CD47-likeÂ
Community Requests
Myxoma virus
host range factor, host defense modulator
0
IDP90213
(
show subtarget assignments
)
8
purified
No
MYXV_gp033
9633665
m029L
m029L, m29L
115
IFN resistance, PKR inhibitor
Community Requests
2YT4
19.1%
Myxoma virus
host range factor, host defense modulator
0
IDP90214
(
show subtarget assignments
)
8
expressed
No
MYXV_gp017
9633649
m013L
m013L, M013L
126
interferon inducible protein
Community Requests
Myxoma virus
unknown
0
IDP90219
(
show subtarget assignments
)
8
expressed
No
MYXV_gp011
9633802
m008L
m008L, m8
515
contains kelch motifs, similar to MYX-L-m006R
Community Requests
2XN4
11.5%
Myxoma virus
unknown
0
IDP90215
(
show subtarget assignments
)
8
expressed
No
MYXV_gp009
9633800
m006L
m006L, m6
509
contains kelch motifs, similar to MYX-L-m006R
Community Requests
1X2J
13.9%
Myxoma virus
unknown
0
IDP90216
(
show subtarget assignments
)
8
expressed
No
MYXV_gp008
9633799
m005L
m005L, m5, M-T5
483
ankyrin motif, similar to VACV-Cop:B4R. Possible apoptosis regulator.
Community Requests
1N0R
8.5%
Myxoma virus
host range factor, host defense modulator
0
IDP90217
(
show subtarget assignments
)
8
soluble
No
MYXV_gp004
9633795
m003.1L
m003.1L, m3.1
151
similar to VACV-Cop:B22R, member of Poxvirus A4/B15 family. This is a family of ...
Community Requests
2VVY
29.8%
Myxoma virus
unknown
0
IDP91724
(
show subtarget assignments
)
8
selected
No
NP_115805
45331215
LZTS2
leucine zipper putative tumor suppressor...
669
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2I1J
10.9%
Homo sapiens
IDP90889
(
show subtarget assignments
)
8
cloned
No
VC0664
15640683
lysS
lysyl-tRNA synthetase [Vibrio cholerae O...
512
Predicted Essential
Community Requests
1E1O
58.8%
Vibrio cholerae
IDP90947
(
show subtarget assignments
)
8
cloned
No
SAR0518
49482744
lysS
lysyl-tRNA synthetase [Staphylococcus au...
495
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3A74
72.1%
Staphylococcus aureus
IDP02443
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0228
16802274
lysS
lysyl-tRNA synthetase [Listeria monocyto...
498
Predicted involvement or location on the cell wall; Drug Target Homologs
Phase 3: June 2008
3A74
69.7%
Listeria monocytogenes
Protein synthesis
tRNA aminoacylation
IDP90685
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj0401
15791768
lysS
lysyl-tRNA synthetase [Campylobacter jej...
501
Predicted Essential
Community Requests
1BBU
48.1%
Campylobacter jejuni
IDP90637
(
show subtarget assignments
)
8
soluble
No
YPO0888
16121193
lysS
lysyl-tRNA synthetase [Yersinia pestis C...
505
Predicted Essential
Community Requests
1BBU
85.7%
Yersinia pestis
IDP01080
(
show subtarget assignments
)
0
work_stopped
No
STM4220
16767470
lysC
aspartate kinase III
449
Conserved Gene / Pathway
Phase 2: March 2008
2J0W
93.1%
Salmonella enterica
Amino acid biosynthesis
Aspartate family
IDP90746
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj0582
15791942
lysC
aspartate kinase [Campylobacter jejuni s...
400
Predicted Essential
Community Requests
3AB4
48.9%
Campylobacter jejuni
IDP90618
(
show subtarget assignments
)
8
purified
No
Cj0314
15791682
lysA
diaminopimelate decarboxylase [Campyloba...
402
Predicted Essential
Community Requests
2QGH
60.2%
Campylobacter jejuni
IDP00434
(
show subtarget assignments
)
1
cloned
No
YPO0796
16121108
lysA
diaminopimelate decarboxylase
420
Drug Target Function
Phase 2: March 2008
1KNW
76.9%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP91697
(
show subtarget assignments
)
8
selected
No
NP_002341
4505055
LYN
tyrosine-protein kinase Lyn isoform A [H...
512
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2C0I
66.6%
Homo sapiens
IDP04226
(
show subtarget assignments
)
1
cloned
No
CPF_0171
110799571
luxS
S-ribosylhomocysteinase [Clostridium per...
151
conserved gene; putative drug target function;
Phase 4: April 2009
1J6W
51%
Clostridium perfringens
Cellular processes
Other
IDP00617
(
show subtarget assignments
)
1
expressed
No
SACOL1880
57284800
lukD
leukotoxin LukD
327
Virulence Associated Factor
Phase 2: March 2008
1PVL
75.5%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP90356
(
show subtarget assignments
)
8
cloned
No
CT080
15604799
ltuB
late transcription unit B protein [Chlam...
97
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90390
(
show subtarget assignments
)
8
cloned
No
CT_377
3328802
ltuA
hypothetical protein [Chlamydia trachoma...
46
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP04722
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1357
115347116
ltaA
L-allo-threonine aldolase [Yersinia pest...
339
conserved gene; putative drug target function;
Phase 4: April 2009
1LW4
46.5%
Yersinia pestis
Energy metabolism
Amino acids and amines
IDP00125
(
show subtarget assignments
)
0
work_stopped
No
NT01ST1183
16764320
lrp
leucine-responsive transcriptional regul...
164
Phase 1: October 2007
2GQQ
98.8%
Salmonella enterica
Central intermediary metabolism
Other
IDP00094
(
show subtarget assignments
)
0
work_stopped
No
NT01SF0993
30040622
lrp
regulator for leucine (or lrp) regulon a...
164
Phase 1: October 2007
2GQQ
99.4%
Shigella flexneri
Central intermediary metabolism
Other
IDP02007
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM2330
16765657
lrhA
NADH dehydrogenase transcriptional repre...
312
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3ONM
38.8%
Salmonella enterica
Energy metabolism
Aerobic
IDP90892
(
show subtarget assignments
)
8
cloned
No
YPO1396
16121676
lpxK
tetraacyldisaccharide 4'-kinase [Yersini...
328
Predicted Essential
Community Requests
Yersinia pestis
IDP01928
(
show subtarget assignments
)
1
cloned
No
FTT0286c
56707440
lpxD1
UDP-3-O-[3-hydroxymyristoyl] glucosamine...
347
Drug Target
Phase 3: June 2008
2IU8
33.4%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90874
(
show subtarget assignments
)
8
expressed
No
YPO1054
16121354
lpxD
UDP-3-O-[3-hydroxymyristoyl] glucosamine...
340
Predicted Essential
Community Requests
3EH0
82.4%
Yersinia pestis
IDP01632
(
show subtarget assignments
)
1
cloned
No
FTT1571c
56708597
lpxD
UDP-3-O-[3-hydroxymyristoyl] glucosamine...
337
Drug Target
Phase 3: June 2008
3EH0
45.1%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90716
(
show subtarget assignments
)
8
soluble
No
Cj0576
15791936
lpxD
UDP-3-O-[3-hydroxymyristoyl] glucosamine...
321
Predicted Essential
Community Requests
2IU8
35.5%
Campylobacter jejuni
IDP00307
(
show subtarget assignments
)
1
expressed
No
CBU_0142
29653500
lpxC
UDP-3-0-acyl N-acetylglucosamine deacety...
303
Drug Target Function
Phase 2: March 2008
2VES
65.7%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP01697
(
show subtarget assignments
)
6
cloned
No
AAC68008
3328839
lpxB
Lipid A Disaccharide Synthase [Chlamydia...
607
LpxB is responsible for the formation of genus-specific lipolpolysaccharide epit...
Phase 3: June 2008
Chlamydia trachomatis
N/A
N/A
IDP90860
(
show subtarget assignments
)
8
cloned
No
YPO1057
16121357
lpxB
lipid-A-disaccharide synthase [Yersinia ...
394
Predicted Essential
Community Requests
Yersinia pestis
IDP01019
(
show subtarget assignments
)
0
work_stopped
No
STM0228
16763618
lpxA
UDP-N-acetylglucosamine acyltransferase ...
262
Essential Gene
Phase 2: March 2008
1LXA
93.5%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90748
(
show subtarget assignments
)
8
in_pdb
3R0S
Yes
Cj0274
15791645
lpxA
UDP-N-acetylglucosamine acyltransferase ...
263
Predicted Essential
Community Requests
3R0S
100%
Campylobacter jejuni
IDP90556
(
show subtarget assignments
)
8
cloned
No
YPO1056
16121356
lpxA
UDP-N-acetylglucosamine acyltransferase
262
Predicted Essential
Community Requests
1LXA
81.7%
Yersinia pestis
IDP01633
(
show subtarget assignments
)
1
soluble
No
FTT1569c
56708595
lpxA
UDP-N-acetylglucosamine acyltransferase ...
259
Conserved; Drug target functions
Phase 3: June 2008
1LXA
43.6%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00082
(
show subtarget assignments
)
0
work_stopped
No
NTL01ST4427
16423142
lplA
lipoate-protein ligase A
338
Phase 1: October 2007
1X2G
93.2%
Salmonella enterica
Cell envelope
Other
IDP91591
(
show subtarget assignments
)
8
selected
No
Atu2521
15889786
lpiA
protein regulated by acid pH [Agrobacter...
866
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Agrobacterium tumefaciens
IDP02101
(
show subtarget assignments
)
1
expressed
No
STM3638
16766924
lpfC
long polar fimbrial outer membrane usher...
842
Conserved; Drug target functions
Phase 3: June 2008
3RFZ
44.8%
Salmonella enterica
Unclassified
Role category not yet assigned
IDP00744
(
show subtarget assignments
)
1
soluble
No
SACOL1563
57284661
lpdA
2-oxoisovalerate dehydrogenase, E3 compo...
473
Drug Target Function
Phase 2: March 2008
3URH
37%
Staphylococcus aureus
Energy metabolism
Amino acids and amines
IDP91813
(
show subtarget assignments
)
8
soluble
No
b0116
1786307
lpd
lipoamide dehydrogenase, E3 component is...
474
potential drug target /
The following proteins are either GNAT acetyltransferases thought to acetylate p...
Community Requests
1BHY
63.6%
Escherichia coli
IDP02297
(
show subtarget assignments
)
1
cloned
No
FTT1235c
56708297
lpcC
glycosyl transferase group 1 family prot...
354
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
2GEJ
17.8%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP04393
(
show subtarget assignments
)
1
cloned
No
CPF_1645
110798596
lonB
ATP-dependent protease LonB [Clostridium...
570
conserved gene; putative drug target function;
Phase 4: April 2009
3K1J
29.4%
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP01132
(
show subtarget assignments
)
1
soluble
No
BA_4703
30259197
loN2
ATP-dependent protease LA
557
Drug Target Function
Phase 2: March 2008
3K1J
26.2%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02793
(
show subtarget assignments
)
1
cloned
No
GBAA4702
47530001
loN
ATP-dependent protease La 1 [Bacillus an...
773
Drug target motif; Involved in sporulation; Drug target functions
Phase 3: June 2008
3M6A
53.7%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01644
(
show subtarget assignments
)
1
cloned
No
FTT0626
56707751
lon
DNA-binding, ATP-dependent protease La [...
774
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3M6A
37.7%
Francisella tularensis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP90346
(
show subtarget assignments
)
8
cloned
No
CT344
15605067
lon
ATP-dependent protease La [Chlamydia tra...
819
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3M6A
30.8%
Chlamydia trachomatis
IDP02684
(
show subtarget assignments
)
1
cloned
No
FTT0405
56707554
lolD
lipoprotein releasing system, subunit D,...
231
Conserved; Drug target functions
Phase 3: June 2008
1F3O
44.6%
Francisella tularensis
Transport and binding proteins
Unknown substrate
IDP00958
(
show subtarget assignments
)
1
soluble
No
STM1218
16764573
lolD
lipoprotein transporter ATP-binding subu...
233
Conserved Gene / Pathway
Phase 2: March 2008
2PCJ
43.3%
Salmonella enterica
Transport and binding proteins
Unknown substrate
IDP01447
(
show subtarget assignments
)
1
in_crystallization_trials
No
VC2181
15642180
lolB
outer membrane lipoprotein LolB
211
Conserved Gene / Pathway
Phase 2: March 2008
1IWM
30.3%
Vibrio cholerae
Cell envelope
Other
IDP02066
(
show subtarget assignments
)
1
cloned
No
YPO1377
16121657
lolA
outer-membrane lipoprotein carrier prote...
202
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
1IWL
66.3%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP91759
(
show subtarget assignments
)
8
selected
No
XP_001471691
149251757
LOC100044207
PREDICTED: hypothetical protein [Mus mus...
402
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
3E4C
46.3%
Mus musculus
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