Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00160 (show subtarget assignments)	1	soluble	No	VC0834	15640851	tcpS	toxin co-regulated pilus biosynthesis pr...	152	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00159 (show subtarget assignments)	1	purified	No	VC0831	15640848	tcpC	toxin co-regulated pilus biosynthesis ou...	489	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00158 (show subtarget assignments)	1	soluble	No	VC0830	15640847	tcpQ	toxin co-regulated pilus biosynthesis pr...	150	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00157 (show subtarget assignments)	1	soluble	No	VC0829	15640846	tcpB	toxin co-regulated pilus biosynthesis pr...	430	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01345 (show subtarget assignments)	1	soluble	No	VC0824	15640841	tpx	tagD protein	164	Conserved Gene / Pathway	Phase 2: March 2008	1QXH	50%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP01511 (show subtarget assignments)	1	expressed	No	VC0794	15640812		hypothetical protein VC0794	139	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04498 (show subtarget assignments)	1	purified	No	VC0791	15640810		sensor kinase citA [Vibrio cholerae O1 b...	565	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2J80	9.7%	Vibrio cholerae	Regulatory functions	Other

IDP00147 (show subtarget assignments)	1	expressed	No	VC0780	15640799	vibD	vibriobactin synthase component D	261	Virulence	Phase 1: October 2007			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00143 (show subtarget assignments)	1	soluble	No	VC0779	15640798	viuC	vibriobactin and enterobactin ABC transp...	279	Virulence	Phase 1: October 2007	1B0U	29%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00146 (show subtarget assignments)	1	soluble	No	VC0778	15640797	viuG	vibriobactin and enterobactin ABC transp...	358	Virulence	Phase 1: October 2007	2QI9	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00145 (show subtarget assignments)	1	expressed	No	VC0777	15640796	viuD	vibriobactin and enterobactin ABC transp...	350	Virulence	Phase 1: October 2007	2NQ2	30.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00144 (show subtarget assignments)	1	soluble	No	VC0776	15640795	viuP	vibriobactin and enterobactin ABC transp...	325	Virulence	Phase 1: October 2007	3R5S	91.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01401 (show subtarget assignments)	1	purified	No	VC0773	15640792		vibriobactin-specific isochorismate synt...	395	Drug Target Function	Phase 2: March 2008	3OS6	44.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01400 (show subtarget assignments)	1	expressed	No	VC0772	15640791		vibriobactin-specific 2,3-dihydroxybenzo...	543	Conserved Gene / Pathway	Phase 2: March 2008	1MD9	51.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01399 (show subtarget assignments)	1	in_crystallization_trials	No	VC0771	15640790		vibriobactin-specific isochorismatase	293	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	44.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04497 (show subtarget assignments)	1	soluble	No	VC0768	9655215		GMP synthase [Vibrio cholerae O1 biovar ...	517	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GPM	80.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP04364 (show subtarget assignments)	1	crystallized	No	VC0767	15640786		inositol-5-monophosphate dehydrogenase [...	489	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3TSB	56.6%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP01398 (show subtarget assignments)	1	cloned	No	VC0762	15640781		outer membrane protein assembly complex ...	386	Conserved Gene / Pathway	Phase 2: March 2008	3P1L	43.3%	Vibrio cholerae	Cell envelope	Other

IDP90628 (show subtarget assignments)	8	in_crystallization_trials	No	VC0760	15640779	hisS	histidyl-tRNA synthetase [Vibrio cholera...	422	Predicted Essential	Community Requests	1KMM	74.5%	Vibrio cholerae

IDP04321 (show subtarget assignments)	1	cloned	No	VC0756	15640775	ndk	nucleoside diphosphate kinase [Vibrio ch...	142	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2HUR	64.8%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP01397 (show subtarget assignments)	1	purified	No	VC0755	161582019		aminopeptidase B	429	Drug Target Function	Phase 2: March 2008	3H8E	32.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01396 (show subtarget assignments)	1	purified	No	VC0752	15640771	hscA	chaperone protein HscA	616	Conserved Gene / Pathway	Phase 2: March 2008	2KHO	40.9%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01304 (show subtarget assignments)	1	in_pdb 3HHO	Yes	VC0751	15640770	hscB	co-chaperone HscB	171	Conserved Gene / Pathway	Phase 2: March 2008	3HHO	100%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP01510 (show subtarget assignments)	1	in_crystallization_trials	No	VC0731	15640750		antioxidant, AhpC/Tsa family	207	Conserved Gene / Pathway	Phase 2: March 2008	1ZOF	55.1%	Vibrio cholerae	Cellular processes	Detoxification

IDP01333 (show subtarget assignments)	1	purified	No	VC0726	15640745		phosphate ABC transporter, ATP-binding p...	273	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	33%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01395 (show subtarget assignments)	1	purified	No	VC0704	15640723		spermidine/putrescine ABC transporter, p...	359	Conserved Gene / Pathway	Phase 2: March 2008	3TTK	27.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01394 (show subtarget assignments)	1	soluble	No	VC0700	15640719		soluble lytic murein transglycosylase	648	Drug Target Function	Phase 2: March 2008	1QSA	33.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91164 (show subtarget assignments)	8	purified	No	VC0695	15640714		phospho-2-dehydro-3-deoxyheptonate aldol...	357	potential drug target / Shikimate pathway enzyme	Community Requests	1GG1	50.7%	Vibrio cholerae

IDP01393 (show subtarget assignments)	1	in_crystallization_trials	No	VC0684	15640703		peptidyl-prolyl cis-trans isomerase, FKB...	144	Conserved Gene / Pathway	Phase 2: March 2008	2K8I	33.3%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP90823 (show subtarget assignments)	8	soluble	No	VC0682	15640701	ileS	isoleucyl-tRNA synthetase [Vibrio choler...	949	Predicted Essential	Community Requests	1FFY	43.1%	Vibrio cholerae

IDP04156 (show subtarget assignments)	1	expressed	No	VC0681	9655120		riboflavin kinase/FMN adenylyltransferas...	322	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1MRZ	32.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90576 (show subtarget assignments)	8	soluble	No	VC0679	15640698	rpsT	30S ribosomal protein S20 [Vibrio choler...	86	Predicted Essential	Community Requests	1VS5	70.9%	Vibrio cholerae

IDP04496 (show subtarget assignments)	1	expressed	No	VC0675	15640694	thyA	thymidylate synthase [Vibrio cholerae O1...	283	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3V8H	35.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	2'-Deoxyribonucleotide metabolism

IDP90889 (show subtarget assignments)	8	cloned	No	VC0664	15640683	lysS	lysyl-tRNA synthetase [Vibrio cholerae O...	512	Predicted Essential	Community Requests	1E1O	58.8%	Vibrio cholerae

IDP90960 (show subtarget assignments)	8	expressed	No	VC0658	81545351		C-di-GMP phosphodiesterase A-related pro...	685	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	18.7%	Vibrio cholerae

IDP90951 (show subtarget assignments)	8	purified	No	VC0653	81545356		C-di-GMP phosphodiesterase A-related pro...	684	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	3PJW	15.5%	Vibrio cholerae

IDP01392 (show subtarget assignments)	1	purified	No	VC0648	15640668		lipoprotein NlpI	303	Conserved Gene / Pathway	Phase 2: March 2008	1XNF	44.2%	Vibrio cholerae	Cell envelope	Other

IDP01332 (show subtarget assignments)	1	purified	No	VC0639	15640659		phosphoglucomutase/phosphomannomutase fa...	446	Drug Target Function	Phase 2: March 2008	3PDK	46.6%	Vibrio cholerae	Energy metabolism	Sugars

IDP90643 (show subtarget assignments)	8	soluble	No	VC0638	15640658		dihydropteroate synthase [Vibrio cholera...	278	Predicted Essential	Community Requests	1AJ0	55.8%	Vibrio cholerae

IDP01391 (show subtarget assignments)	1	cloned	No	VC0633	15640653		outer membrane protein OmpU	350	Conserved Gene / Pathway	Phase 2: March 2008	3HW9	27.3%	Vibrio cholerae	Cell envelope	Other

IDP05300 (show subtarget assignments)	1	cloned	No	VC_0631	9655066		tyrosyl-tRNA synthetase [Vibrio cholerae...	395	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1H3E	47.8%	Vibrio cholerae	Protein synthesis: tRNA aminoacylation

IDP90615 (show subtarget assignments)	8	in_crystallization_trials	No	VC0626	15640646		glutamate-1-semialdehyde aminotransferas...	432	Predicted Essential	Community Requests	4E77	72%	Vibrio cholerae

IDP04495 (show subtarget assignments)	1	soluble	No	VC0622	15640642		sensory box sensor histidine kinase/resp...	1177	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	6.6%	Vibrio cholerae	Regulatory functions	Other

IDP01390 (show subtarget assignments)	1	purified	No	VC0617	15640637		peptide ABC transporter, ATP-binding pro...	327	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	24.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01389 (show subtarget assignments)	1	purified	No	VC0610	15640630		iron(III) ABC transporter, ATP-binding p...	343	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	36.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01388 (show subtarget assignments)	1	soluble	No	VC0608	15640628		iron(III) ABC transporter, periplasmic i...	352	Conserved Gene / Pathway	Phase 2: March 2008	1Q35	55.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP05224 (show subtarget assignments)	1	cloned	No	VC_0595	9655026		glutamyl-tRNA synthetase-related protein...	304	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1NZJ	55.3%	Vibrio cholerae	Unknown function: General

IDP04494 (show subtarget assignments)	1	expressed	No	VC0591	15640612	panC	pantoate--beta-alanine ligase [Vibrio ch...	293	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3Q10	57%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP01331 (show subtarget assignments)	1	purified	No	VC0589	15640610		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	28.9%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01516 (show subtarget assignments)	1	crystallized	No	VC0576	15640598	sspA	stringent starvation protein A	211	Conserved Gene / Pathway	Phase 2: March 2008	1YY7	73.9%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP01303 (show subtarget assignments)	1	purified	No	VC0573	15640595		ubiquinol--cytochrome c reductase, iron-...	197	Conserved Gene / Pathway	Phase 2: March 2008	2FYN	37.6%	Vibrio cholerae	Energy metabolism	Electron transport

IDP01387 (show subtarget assignments)	1	cloned	No	VC0566	15640588		protease DO	456	Drug Target Function	Phase 2: March 2008	2ZLE	57.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01386 (show subtarget assignments)	1	soluble	No	VC0565	15640587		protease DegS	352	Drug Target Function	Phase 2: March 2008	1SOT	47.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90606 (show subtarget assignments)	8	in_crystallization_trials	No	VC0563	15640585	trmD	tRNA (guanine-N(1)-)-methyltransferase [...	247	Predicted Essential	Community Requests	1P9P	78.1%	Vibrio cholerae

IDP01385 (show subtarget assignments)	1	cloned	No	VC0560	15640582		signal recognition particle protein	461	Drug Target Function	Phase 2: March 2008	2XXA	73.1%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP01330 (show subtarget assignments)	1	purified	No	VC0557	15640579		S-ribosylhomocysteinase	172	Conserved Gene / Pathway	Phase 2: March 2008	1J6W	71.5%	Vibrio cholerae	Cellular processes	Other

IDP01384 (show subtarget assignments)	1	purified	No	VC0554	15640576		protease, insulinase family/protease, in...	952	Drug Target Function	Phase 2: March 2008	1Q2L	19.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01509 (show subtarget assignments)	1	expressed	No	VC0549	15640571		oxaloacetate decarboxylase subunit gamma...	117	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04155 (show subtarget assignments)	1	cloned	No	VC0547	9654975		aspartokinase, alpha and beta subunits [...	395	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3L76	39.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP01383 (show subtarget assignments)	1	in_crystallization_trials	No	VC0538	15640560		thiosulfate ABC transporter, periplasmic...	333	Conserved Gene / Pathway	Phase 2: March 2008	1SBP	42.3%	Vibrio cholerae	Transport and binding proteins	Anions

IDP01382 (show subtarget assignments)	1	cloned	No	VC0533	15640555		lipoprotein NlpD	311	Drug Target Function	Phase 2: March 2008	1QWY	24.1%	Vibrio cholerae	Cell envelope	Other

IDP01381 (show subtarget assignments)	1	purified	No	VC0529	15640551	ispF	2-C-methyl-D-erythritol 2,4-cyclodiphosp...	158	Drug Target Function	Phase 2: March 2008	1GX1	74.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90579 (show subtarget assignments)	8	soluble	No	VC0528	15640550	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	232	We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...	Community Requests	1H3M	53.9%	Vibrio cholerae

IDP04085 (show subtarget assignments)	1	expressed	No	VC0525	15640547		2-amino-4-hydroxy-6-hydroxymethyldihydro...	195	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2BMB	30.8%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01380 (show subtarget assignments)	1	in_pdb 3O1K	Yes	VC0524	15640546		dihydroneopterin aldolase FolB, putative...	129	Conserved Gene / Pathway	Phase 2: March 2008	3O1K	100%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90734 (show subtarget assignments)	8	selected	No	VC0517	15640541		RNA polymerase sigma factor RpoD [Vibrio...	625	Predicted Essential	Community Requests	3IYD	78.1%	Vibrio cholerae

IDP00153 (show subtarget assignments)	1	expressed	No	VC0475	15640502	irgA	enterobactin receptor	652	Virulence	Phase 1: October 2007	2HDF	37.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01379 (show subtarget assignments)	1	purified	No	VC0474	15640501		iron-regulated virulence regulatory prot...	298	Conserved Gene / Pathway	Phase 2: March 2008	3SZP	27.2%	Vibrio cholerae	Regulatory functions	Other

IDP90798 (show subtarget assignments)	8	in_crystallization_trials	No	VC0472	15640499		S-adenosylmethionine synthetase [Vibrio ...	385	Predicted Essential	Community Requests	1FUG	87.5%	Vibrio cholerae

IDP05770 (show subtarget assignments)	1	cloned	No	VC_0465	9654891		tyrosyl-tRNA synthetase [Vibrio cholerae...	434	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2TS1	50%	Vibrio cholerae	Protein synthesis: tRNA aminoacylation

IDP01328 (show subtarget assignments)	1	purified	No	VC0443	15640470	ksgA	dimethyladenosine transferase	282	Conserved Gene / Pathway	Phase 2: March 2008	3TPZ	61.7%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP90885 (show subtarget assignments)	8	purified	No	VC0440	15640467		dihydrofolate reductase [Vibrio cholerae...	165	Predicted Essential	Community Requests	3IA4	52.7%	Vibrio cholerae

IDP01327 (show subtarget assignments)	1	purified	No	VC0418	15640445	maf	Maf-like protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	40%	Vibrio cholerae	Cellular processes	Cell division

IDP01378 (show subtarget assignments)	1	cloned	No	VC0410	15640437		MSHA pilin protein MshC	162	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01377 (show subtarget assignments)	1	cloned	No	VC0409	15640436		MSHA pilin protein MshA	178	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00156 (show subtarget assignments)	1	purified	No	VC0407	15640434	mshF	MSHA biogenesis protein MshF	150	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00155 (show subtarget assignments)	1	in_crystallization_trials	No	VC0405	15640432	mshE	MSHA biogenesis protein MshE	575	Virulence	Phase 1: October 2007	1P9R	31.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP00151 (show subtarget assignments)	1	purified	No	VC0403	15640430	mshM	MSHA biogenesis protein MshM	281	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00150 (show subtarget assignments)	1	purified	No	VC0402	15640429	mshL	MSHA biogenesis protein MshL	559	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP00141 (show subtarget assignments)	1	crystallized	No	VC0401	15640428	mshK	MSHA biogenesis protein MshK	105	Virulence	Phase 1: October 2007			Vibrio cholerae	Cellular processes	Pathogenesis

IDP01376 (show subtarget assignments)	1	soluble	No	VC0400	15640427		MSHA biogenesis protein MshJ	216	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Cellular processes	Pathogenesis

IDP90804 (show subtarget assignments)	8	soluble	No	VC0397	15640424		single-strand DNA-binding protein [Vibri...	177	Predicted Essential	Community Requests	1EQQ	75.1%	Vibrio cholerae

IDP91065 (show subtarget assignments)	8	expressed	No	VC0395_A0354	147674291	tcpB	toxin co-regulated pilus biosynthesis pr...	430	vaccine candidate / For Vibrio cholerae to colonize the human intestine and cause cholera, it must e...	Community Requests			Vibrio cholerae

IDP04015 (show subtarget assignments)	1	purified	No	VC0395	15640422		UTP--glucose-1-phosphate uridylyltransfe...	291	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3JUJ	58.1%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides

IDP90903 (show subtarget assignments)	8	purified	No	VC0390	15640417	metH	B12-dependent methionine synthase [Vibri...	1226	Predicted Essential	Community Requests	3BUL	33.8%	Vibrio cholerae

IDP01329 (show subtarget assignments)	1	in_pdb 3HJB	No	VC0374	15640401	pgi	glucose-6-phosphate isomerase	550	Drug Target Function	Phase 2: March 2008	3HJB	99.8%	Vibrio cholerae	Energy metabolism	Glycolysis/gluconeogenesis

IDP01375 (show subtarget assignments)	1	in_crystallization_trials	No	VC0372	15640399	alr	alanine racemase	375	Conserved Gene / Pathway	Phase 2: March 2008	2RJG	57.3%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90569 (show subtarget assignments)	8	soluble	No	VC0369	15640396	rplI	50S ribosomal protein L9 [Vibrio cholera...	149	Predicted Essential	Community Requests	1P85	76.5%	Vibrio cholerae

IDP01374 (show subtarget assignments)	1	purified	No	VC0344	15640371		N-acetylmuramoyl-L-alanine amidase	581	Conserved Gene / Pathway	Phase 2: March 2008	3NE8	13.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01373 (show subtarget assignments)	1	soluble	No	VC0335	15640362		NlpD-related protein	382	Drug Target Function	Phase 2: March 2008	3SLU	13.1%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90881 (show subtarget assignments)	8	expressed	No	VC0329	15640356		DNA-directed RNA polymerase subunit beta...	1401	Predicted Essential	Community Requests	3IYD	82.4%	Vibrio cholerae

IDP90876 (show subtarget assignments)	8	selected	No	VC0320	15640347		pantothenate kinase [Vibrio cholerae O1 ...	375	Predicted Essential	Community Requests	1ESM	53.3%	Vibrio cholerae

IDP90597 (show subtarget assignments)	8	soluble	No	VC0319	15640346		biotin--protein ligase [Vibrio cholerae ...	320	Predicted Essential	Community Requests	1BIA	54.7%	Vibrio cholerae

IDP01372 (show subtarget assignments)	1	in_pdb 3I99	No	VC0318	15640345	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	357	Drug Target Function	Phase 2: March 2008	3I99	100%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01319 (show subtarget assignments)	1	soluble	No	VC0312	15640339	fre	FMN reductase	236	Conserved Gene / Pathway	Phase 2: March 2008	1QFJ	48.3%	Vibrio cholerae	Energy metabolism	Electron transport

IDP90541 (show subtarget assignments)	8	crystallized	No	VC0297	15640325		3-dehydroquinate dehydratase [Vibrio cho...	150	Predicted Essential	Community Requests	3LWZ	70.7%	Vibrio cholerae

IDP90589 (show subtarget assignments)	8	soluble	No	VC0296	15640324		acetyl-CoA carboxylase [Vibrio cholerae ...	196	Predicted Essential	Community Requests	1A6X	37.2%	Vibrio cholerae

IDP90725 (show subtarget assignments)	8	soluble	No	VC0295	15640323		acetyl-CoA carboxylase biotin carboxylas...	447	Predicted Essential	Community Requests	1BNC	85.5%	Vibrio cholerae

IDP00132 (show subtarget assignments)	1	purified	No	VC_0288	9654699	VC0288	Vibrio cholerae O1 biovar eltor str. N16...	618	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2GP4	53.9%	Vibrio cholerae	Energy metabolism	Entner-Doudoroff

IDP90620 (show subtarget assignments)	8	expressed	No	VC0275	15640304		phosphoribosylamine--glycine ligase [Vib...	429	Predicted Essential	Community Requests	1GSO	77.9%	Vibrio cholerae

IDP00160
(show subtarget assignments)

1

soluble

No

VC0834

15640851

tcpS

toxin co-regulated pilus biosynthesis pr...

152

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00159
(show subtarget assignments)

1

purified

No

VC0831

15640848

tcpC

toxin co-regulated pilus biosynthesis ou...

489

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00158
(show subtarget assignments)

1

soluble

No

VC0830

15640847

tcpQ

toxin co-regulated pilus biosynthesis pr...

150

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00157
(show subtarget assignments)

1

soluble

No

VC0829

15640846

tcpB

toxin co-regulated pilus biosynthesis pr...

430

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01345
(show subtarget assignments)

1

soluble

No

VC0824

15640841

tpx

tagD protein

164

Conserved Gene / Pathway

Phase 2: March 2008

1QXH

50%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01511
(show subtarget assignments)

1

expressed

No

VC0794

15640812

hypothetical protein VC0794

139

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04498
(show subtarget assignments)

1

purified

No

VC0791

15640810

sensor kinase citA [Vibrio cholerae O1 b...

565

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2J80

9.7%

Vibrio cholerae

Regulatory functions

Other

IDP00147
(show subtarget assignments)

1

expressed

No

VC0780

15640799

vibD

vibriobactin synthase component D

261

Virulence

Phase 1: October 2007

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00143
(show subtarget assignments)

1

soluble

No

VC0779

15640798

viuC

vibriobactin and enterobactin ABC transp...

279

Virulence

Phase 1: October 2007

1B0U

29%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00146
(show subtarget assignments)

1

soluble

No

VC0778

15640797

viuG

vibriobactin and enterobactin ABC transp...

358

Virulence

Phase 1: October 2007

2QI9

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00145
(show subtarget assignments)

1

expressed

No

VC0777

15640796

viuD

vibriobactin and enterobactin ABC transp...

350

Virulence

Phase 1: October 2007

2NQ2

30.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00144
(show subtarget assignments)

1

soluble

No

VC0776

15640795

viuP

vibriobactin and enterobactin ABC transp...

325

Virulence

Phase 1: October 2007

3R5S

91.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01401
(show subtarget assignments)

1

purified

No

VC0773

15640792

vibriobactin-specific isochorismate synt...

395

Drug Target Function

Phase 2: March 2008

3OS6

44.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01400
(show subtarget assignments)

1

expressed

No

VC0772

15640791

vibriobactin-specific 2,3-dihydroxybenzo...

543

Conserved Gene / Pathway

Phase 2: March 2008

1MD9

51.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01399
(show subtarget assignments)

1

in_crystallization_trials

No

VC0771

15640790

vibriobactin-specific isochorismatase

293

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

44.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04497
(show subtarget assignments)

1

soluble

No

VC0768

9655215

GMP synthase [Vibrio cholerae O1 biovar ...

517

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GPM

80.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP04364
(show subtarget assignments)

1

crystallized

No

VC0767

15640786

inositol-5-monophosphate dehydrogenase [...

489

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3TSB

56.6%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP01398
(show subtarget assignments)

1

cloned

No

VC0762

15640781

outer membrane protein assembly complex ...

386

Conserved Gene / Pathway

Phase 2: March 2008

3P1L

43.3%

Vibrio cholerae

Cell envelope

Other

IDP90628
(show subtarget assignments)

8

in_crystallization_trials

No

VC0760

15640779

hisS

histidyl-tRNA synthetase [Vibrio cholera...

422

Predicted Essential

Community Requests

1KMM

74.5%

Vibrio cholerae

IDP04321
(show subtarget assignments)

1

cloned

No

VC0756

15640775

ndk

nucleoside diphosphate kinase [Vibrio ch...

142

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2HUR

64.8%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP01397
(show subtarget assignments)

1

purified

No

VC0755

161582019

aminopeptidase B

429

Drug Target Function

Phase 2: March 2008

3H8E

32.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01396
(show subtarget assignments)

1

purified

No

VC0752

15640771

hscA

chaperone protein HscA

616

Conserved Gene / Pathway

Phase 2: March 2008

2KHO

40.9%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01304
(show subtarget assignments)

1

in_pdb
3HHO

Yes

VC0751

15640770

hscB

co-chaperone HscB

171

Conserved Gene / Pathway

Phase 2: March 2008

3HHO

100%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP01510
(show subtarget assignments)

1

in_crystallization_trials

No

VC0731

15640750

antioxidant, AhpC/Tsa family

207

Conserved Gene / Pathway

Phase 2: March 2008

1ZOF

55.1%

Vibrio cholerae

Cellular processes

Detoxification

IDP01333
(show subtarget assignments)

1

purified

No

VC0726

15640745

phosphate ABC transporter, ATP-binding p...

273

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

33%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01395
(show subtarget assignments)

1

purified

No

VC0704

15640723

spermidine/putrescine ABC transporter, p...

359

Conserved Gene / Pathway

Phase 2: March 2008

3TTK

27.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01394
(show subtarget assignments)

1

soluble

No

VC0700

15640719

soluble lytic murein transglycosylase

648

Drug Target Function

Phase 2: March 2008

1QSA

33.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91164
(show subtarget assignments)

8

purified

No

VC0695

15640714

phospho-2-dehydro-3-deoxyheptonate aldol...

357

potential drug target / Shikimate pathway enzyme

Community Requests

1GG1

50.7%

Vibrio cholerae

IDP01393
(show subtarget assignments)

1

in_crystallization_trials

No

VC0684

15640703

peptidyl-prolyl cis-trans isomerase, FKB...

144

Conserved Gene / Pathway

Phase 2: March 2008

2K8I

33.3%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP90823
(show subtarget assignments)

8

soluble

No

VC0682

15640701

ileS

isoleucyl-tRNA synthetase [Vibrio choler...

949

Predicted Essential

Community Requests

1FFY

43.1%

Vibrio cholerae

IDP04156
(show subtarget assignments)

1

expressed

No

VC0681

9655120

riboflavin kinase/FMN adenylyltransferas...

322

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1MRZ

32.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90576
(show subtarget assignments)

8

soluble

No

VC0679

15640698

rpsT

30S ribosomal protein S20 [Vibrio choler...

86

Predicted Essential

Community Requests

1VS5

70.9%

Vibrio cholerae

IDP04496
(show subtarget assignments)

1

expressed

No

VC0675

15640694

thyA

thymidylate synthase [Vibrio cholerae O1...

283

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3V8H

35.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

2'-Deoxyribonucleotide metabolism

IDP90889
(show subtarget assignments)

8

cloned

No

VC0664

15640683

lysS

lysyl-tRNA synthetase [Vibrio cholerae O...

512

Predicted Essential

Community Requests

1E1O

58.8%

Vibrio cholerae

IDP90960
(show subtarget assignments)

8

expressed

No

VC0658

81545351

C-di-GMP phosphodiesterase A-related pro...

685

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

18.7%

Vibrio cholerae

IDP90951
(show subtarget assignments)

8

purified

No

VC0653

81545356

C-di-GMP phosphodiesterase A-related pro...

684

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

3PJW

15.5%

Vibrio cholerae

IDP01392
(show subtarget assignments)

1

purified

No

VC0648

15640668

lipoprotein NlpI

303

Conserved Gene / Pathway

Phase 2: March 2008

1XNF

44.2%

Vibrio cholerae

Cell envelope

Other

IDP01332
(show subtarget assignments)

1

purified

No

VC0639

15640659

phosphoglucomutase/phosphomannomutase fa...

446

Drug Target Function

Phase 2: March 2008

3PDK

46.6%

Vibrio cholerae

Energy metabolism

Sugars

IDP90643
(show subtarget assignments)

8

soluble

No

VC0638

15640658

dihydropteroate synthase [Vibrio cholera...

278

Predicted Essential

Community Requests

1AJ0

55.8%

Vibrio cholerae

IDP01391
(show subtarget assignments)

1

cloned

No

VC0633

15640653

outer membrane protein OmpU

350

Conserved Gene / Pathway

Phase 2: March 2008

3HW9

27.3%

Vibrio cholerae

Cell envelope

Other

IDP05300
(show subtarget assignments)

1

cloned

No

VC_0631

9655066

tyrosyl-tRNA synthetase [Vibrio cholerae...

395

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1H3E

47.8%

Vibrio cholerae

Protein synthesis: tRNA aminoacylation

IDP90615
(show subtarget assignments)

8

in_crystallization_trials

No

VC0626

15640646

glutamate-1-semialdehyde aminotransferas...

432

Predicted Essential

Community Requests

4E77

72%

Vibrio cholerae

IDP04495
(show subtarget assignments)

1

soluble

No

VC0622

15640642

sensory box sensor histidine kinase/resp...

1177

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

6.6%

Vibrio cholerae

Regulatory functions

Other

IDP01390
(show subtarget assignments)

1

purified

No

VC0617

15640637

peptide ABC transporter, ATP-binding pro...

327

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

24.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01389
(show subtarget assignments)

1

purified

No

VC0610

15640630

iron(III) ABC transporter, ATP-binding p...

343

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

36.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01388
(show subtarget assignments)

1

soluble

No

VC0608

15640628

iron(III) ABC transporter, periplasmic i...

352

Conserved Gene / Pathway

Phase 2: March 2008

1Q35

55.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP05224
(show subtarget assignments)

1

cloned

No

VC_0595

9655026

glutamyl-tRNA synthetase-related protein...

304

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1NZJ

55.3%

Vibrio cholerae

Unknown function: General

IDP04494
(show subtarget assignments)

1

expressed

No

VC0591

15640612

panC

pantoate--beta-alanine ligase [Vibrio ch...

293

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3Q10

57%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP01331
(show subtarget assignments)

1

purified

No

VC0589

15640610

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

28.9%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01516
(show subtarget assignments)

1

crystallized

No

VC0576

15640598

sspA

stringent starvation protein A

211

Conserved Gene / Pathway

Phase 2: March 2008

1YY7

73.9%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP01303
(show subtarget assignments)

1

purified

No

VC0573

15640595

ubiquinol--cytochrome c reductase, iron-...

197

Conserved Gene / Pathway

Phase 2: March 2008

2FYN

37.6%

Vibrio cholerae

Energy metabolism

Electron transport

IDP01387
(show subtarget assignments)

1

cloned

No

VC0566

15640588

protease DO

456

Drug Target Function

Phase 2: March 2008

2ZLE

57.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01386
(show subtarget assignments)

1

soluble

No

VC0565

15640587

protease DegS

352

Drug Target Function

Phase 2: March 2008

1SOT

47.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90606
(show subtarget assignments)

8

in_crystallization_trials

No

VC0563

15640585

trmD

tRNA (guanine-N(1)-)-methyltransferase [...

247

Predicted Essential

Community Requests

1P9P

78.1%

Vibrio cholerae

IDP01385
(show subtarget assignments)

1

cloned

No

VC0560

15640582

signal recognition particle protein

461

Drug Target Function

Phase 2: March 2008

2XXA

73.1%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP01330
(show subtarget assignments)

1

purified

No

VC0557

15640579

S-ribosylhomocysteinase

172

Conserved Gene / Pathway

Phase 2: March 2008

1J6W

71.5%

Vibrio cholerae

Cellular processes

Other

IDP01384
(show subtarget assignments)

1

purified

No

VC0554

15640576

protease, insulinase family/protease, in...

952

Drug Target Function

Phase 2: March 2008

1Q2L

19.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01509
(show subtarget assignments)

1

expressed

No

VC0549

15640571

oxaloacetate decarboxylase subunit gamma...

117

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04155
(show subtarget assignments)

1

cloned

No

VC0547

9654975

aspartokinase, alpha and beta subunits [...

395

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3L76

39.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP01383
(show subtarget assignments)

1

in_crystallization_trials

No

VC0538

15640560

thiosulfate ABC transporter, periplasmic...

333

Conserved Gene / Pathway

Phase 2: March 2008

1SBP

42.3%

Vibrio cholerae

Transport and binding proteins

Anions

IDP01382
(show subtarget assignments)

1

cloned

No

VC0533

15640555

lipoprotein NlpD

311

Drug Target Function

Phase 2: March 2008

1QWY

24.1%

Vibrio cholerae

Cell envelope

Other

IDP01381
(show subtarget assignments)

1

purified

No

VC0529

15640551

ispF

2-C-methyl-D-erythritol 2,4-cyclodiphosp...

158

Drug Target Function

Phase 2: March 2008

1GX1

74.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90579
(show subtarget assignments)

8

soluble

No

VC0528

15640550

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

232

We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...

Community Requests

1H3M

53.9%

Vibrio cholerae

IDP04085
(show subtarget assignments)

1

expressed

No

VC0525

15640547

2-amino-4-hydroxy-6-hydroxymethyldihydro...

195

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2BMB

30.8%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01380
(show subtarget assignments)

1

in_pdb
3O1K

Yes

VC0524

15640546

dihydroneopterin aldolase FolB, putative...

129

Conserved Gene / Pathway

Phase 2: March 2008

3O1K

100%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90734
(show subtarget assignments)

8

selected

No

VC0517

15640541

RNA polymerase sigma factor RpoD [Vibrio...

625

Predicted Essential

Community Requests

3IYD

78.1%

Vibrio cholerae

IDP00153
(show subtarget assignments)

1

expressed

No

VC0475

15640502

irgA

enterobactin receptor

652

Virulence

Phase 1: October 2007

2HDF

37.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01379
(show subtarget assignments)

1

purified

No

VC0474

15640501

iron-regulated virulence regulatory prot...

298

Conserved Gene / Pathway

Phase 2: March 2008

3SZP

27.2%

Vibrio cholerae

Regulatory functions

Other

IDP90798
(show subtarget assignments)

8

in_crystallization_trials

No

VC0472

15640499

S-adenosylmethionine synthetase [Vibrio ...

385

Predicted Essential

Community Requests

1FUG

87.5%

Vibrio cholerae

IDP05770
(show subtarget assignments)

1

cloned

No

VC_0465

9654891

tyrosyl-tRNA synthetase [Vibrio cholerae...

434

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2TS1

50%

Vibrio cholerae

Protein synthesis: tRNA aminoacylation

IDP01328
(show subtarget assignments)

1

purified

No

VC0443

15640470

ksgA

dimethyladenosine transferase

282

Conserved Gene / Pathway

Phase 2: March 2008

3TPZ

61.7%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP90885
(show subtarget assignments)

8

purified

No

VC0440

15640467

dihydrofolate reductase [Vibrio cholerae...

165

Predicted Essential

Community Requests

3IA4

52.7%

Vibrio cholerae

IDP01327
(show subtarget assignments)

1

purified

No

VC0418

15640445

maf

Maf-like protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

40%

Vibrio cholerae

Cellular processes

Cell division

IDP01378
(show subtarget assignments)

1

cloned

No

VC0410

15640437

MSHA pilin protein MshC

162

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01377
(show subtarget assignments)

1

cloned

No

VC0409

15640436

MSHA pilin protein MshA

178

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00156
(show subtarget assignments)

1

purified

No

VC0407

15640434

mshF

MSHA biogenesis protein MshF

150

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00155
(show subtarget assignments)

1

in_crystallization_trials

No

VC0405

15640432

mshE

MSHA biogenesis protein MshE

575

Virulence

Phase 1: October 2007

1P9R

31.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00151
(show subtarget assignments)

1

purified

No

VC0403

15640430

mshM

MSHA biogenesis protein MshM

281

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00150
(show subtarget assignments)

1

purified

No

VC0402

15640429

mshL

MSHA biogenesis protein MshL

559

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP00141
(show subtarget assignments)

1

crystallized

No

VC0401

15640428

mshK

MSHA biogenesis protein MshK

105

Virulence

Phase 1: October 2007

Vibrio cholerae

Cellular processes

Pathogenesis

IDP01376
(show subtarget assignments)

1

soluble

No

VC0400

15640427

MSHA biogenesis protein MshJ

216

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Cellular processes

Pathogenesis

IDP90804
(show subtarget assignments)

8

soluble

No

VC0397

15640424

single-strand DNA-binding protein [Vibri...

177

Predicted Essential

Community Requests

1EQQ

75.1%

Vibrio cholerae

IDP91065
(show subtarget assignments)

8

expressed

No

VC0395_A0354

147674291

tcpB

toxin co-regulated pilus biosynthesis pr...

430

vaccine candidate / For Vibrio cholerae to colonize the human intestine and cause cholera, it must e...

Community Requests

Vibrio cholerae

IDP04015
(show subtarget assignments)

1

purified

No

VC0395

15640422

UTP--glucose-1-phosphate uridylyltransfe...

291

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3JUJ

58.1%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

IDP90903
(show subtarget assignments)

8

purified

No

VC0390

15640417

metH

B12-dependent methionine synthase [Vibri...

1226

Predicted Essential

Community Requests

3BUL

33.8%

Vibrio cholerae

IDP01329
(show subtarget assignments)

1

in_pdb
3HJB

No

VC0374

15640401

pgi

glucose-6-phosphate isomerase

550

Drug Target Function

Phase 2: March 2008

3HJB

99.8%

Vibrio cholerae

Energy metabolism

Glycolysis/gluconeogenesis

IDP01375
(show subtarget assignments)

1

in_crystallization_trials

No

VC0372

15640399

alr

alanine racemase

375

Conserved Gene / Pathway

Phase 2: March 2008

2RJG

57.3%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90569
(show subtarget assignments)

8

soluble

No

VC0369

15640396

rplI

50S ribosomal protein L9 [Vibrio cholera...

149

Predicted Essential

Community Requests

1P85

76.5%

Vibrio cholerae

IDP01374
(show subtarget assignments)

1

purified

No

VC0344

15640371

N-acetylmuramoyl-L-alanine amidase

581

Conserved Gene / Pathway

Phase 2: March 2008

3NE8

13.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01373
(show subtarget assignments)

1

soluble

No

VC0335

15640362

NlpD-related protein

382

Drug Target Function

Phase 2: March 2008

3SLU

13.1%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90881
(show subtarget assignments)

8

expressed

No

VC0329

15640356

DNA-directed RNA polymerase subunit beta...

1401

Predicted Essential

Community Requests

3IYD

82.4%

Vibrio cholerae

IDP90876
(show subtarget assignments)

8

selected

No

VC0320

15640347

pantothenate kinase [Vibrio cholerae O1 ...

375

Predicted Essential

Community Requests

1ESM

53.3%

Vibrio cholerae

IDP90597
(show subtarget assignments)

8

soluble

No

VC0319

15640346

biotin--protein ligase [Vibrio cholerae ...

320

Predicted Essential

Community Requests

1BIA

54.7%

Vibrio cholerae

IDP01372
(show subtarget assignments)

1

in_pdb
3I99

No

VC0318

15640345

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

357

Drug Target Function

Phase 2: March 2008

3I99

100%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01319
(show subtarget assignments)

1

soluble

No

VC0312

15640339

fre

FMN reductase

236

Conserved Gene / Pathway

Phase 2: March 2008

1QFJ

48.3%

Vibrio cholerae

Energy metabolism

Electron transport

IDP90541
(show subtarget assignments)

8

crystallized

No

VC0297

15640325

3-dehydroquinate dehydratase [Vibrio cho...

150

Predicted Essential

Community Requests

3LWZ

70.7%

Vibrio cholerae

IDP90589
(show subtarget assignments)

8

soluble

No

VC0296

15640324

acetyl-CoA carboxylase [Vibrio cholerae ...

196

Predicted Essential

Community Requests

1A6X

37.2%

Vibrio cholerae

IDP90725
(show subtarget assignments)

8

soluble

No

VC0295

15640323

acetyl-CoA carboxylase biotin carboxylas...

447

Predicted Essential

Community Requests

1BNC

85.5%

Vibrio cholerae

IDP00132
(show subtarget assignments)

1

purified

No

VC_0288

9654699

VC0288

Vibrio cholerae O1 biovar eltor str. N16...

618

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2GP4

53.9%

Vibrio cholerae

Energy metabolism

Entner-Doudoroff

IDP90620
(show subtarget assignments)

8

expressed

No

VC0275

15640304

phosphoribosylamine--glycine ligase [Vib...

429

Predicted Essential

Community Requests

1GSO

77.9%

Vibrio cholerae

Targets