Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90096 (show subtarget assignments)	8	expressed	No	ZZZ_0012				476	This protein is a component of a type VI secretion system of enteroaggregative E...	Community Requests			Escherichia coli

IDP90633 (show subtarget assignments)	8	cloned	No	VC1971	15641973		O-succinylbenzoic acid--CoA ligase [Vibr...	476	Predicted Essential	Community Requests	2QVX	27.9%	Vibrio cholerae

IDP01874 (show subtarget assignments)	1	cloned	No	GBAA0062	47525316		hypothetical protein GBAA0062 [Bacillus ...	476	Conserved;	Phase 3: June 2008	3A2K	46.6%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04255 (show subtarget assignments)	1	cloned	No	CPF_1922	110799469	purB	adenylosuccinate lyase [Clostridium perf...	476	conserved gene; putative drug target function;	Phase 4: April 2009	2J91	56.5%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90001 (show subtarget assignments)	8	cloned	No	FTT0094c	56603762	qseC	sensor histidine kinase	475	Drug Target (Community Request)	Community Requests	3A0R	15.8%	Francisella tularensis

IDP01889 (show subtarget assignments)	1	soluble	No	STM0209	16763599	htrA	serine endoprotease [Salmonella typhimur...	475	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2ZLE	87.6%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04468 (show subtarget assignments)	1	cloned	No	YPO2205	115347912	trpC	tryptophan biosynthesis protein TrpCF [Y...	475	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	1PII	69.3%	Yersinia pestis	Amino acid biosynthesis	Aromatic amino acid family

IDP04238 (show subtarget assignments)	1	cloned	No	CPF_0889	110799788		sensor histidine kinase [Clostridium per...	475	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Signal transduction	Two-component systems

IDP05068 (show subtarget assignments)	1	soluble	No	CD2735	126700350		cell surface protein [Clostridium diffic...	475	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KQ8	5.5%	Clostridium difficile	Cell envelope: Other

IDP90296 (show subtarget assignments)	8	purified	No	TGME49_068850	211963242		enolase 2 [Toxoplasma gondii ME49]	475	Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...	Community Requests	3OTR	68.8%	Toxoplasma gondii

IDP05104 (show subtarget assignments)	1	cloned	No	CD1233	126698829		cell surface protein [Clostridium diffic...	475	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP01169 (show subtarget assignments)	1	cloned	No	GBAA_pXO1_0146	47566458	atxA	transcriptional activator atxa, (pxo1-11...	475	Virulence Associated Factor	Phase 2: March 2008	3SQN	20.4%	Bacillus anthracis

IDP00590 (show subtarget assignments)	1	cloned	No	YPO1078	16121379	mltD	predicted membrane-bound lytic murein tr...	475	Drug Target Function	Phase 2: March 2008	1E0G	7.8%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91813 (show subtarget assignments)	8	soluble	No	b0116	1786307	lpd	lipoamide dehydrogenase, E3 component is...	474	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1BHY	63.6%	Escherichia coli

IDP00969 (show subtarget assignments)	1	purified	No	STM1597	161353598	ydcW	putative aldehyde dehydrogenase	474	Conserved Gene / Pathway	Phase 2: March 2008	1WNB	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP00435 (show subtarget assignments)	1	purified	No	YPO0673	16120998	sufI	repressor protein for FtsI	474	Conserved Gene / Pathway	Phase 2: March 2008	2UXT	69.6%	Yersinia pestis	Cellular processes	Cell division

IDP00010 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2144	30256791		uroporphyrin-III C-methyltransferase, pu...	474	Drug Target Homolog	Phase 1: October 2007	1PJQ	24.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90858 (show subtarget assignments)	8	in_crystallization_trials	No	O31153	30179879		Glutamyl-tRNA synthetase (Glutamate--tRN...	474	Predicted Essential	Community Requests	2CFO	40.2%	Vibrio cholerae

IDP90786 (show subtarget assignments)	8	cloned	No	Cj1385	15792708	katA	catalase [Campylobacter jejuni subsp. je...	474	Predicted Essential	Community Requests	2ISA	57.8%	Campylobacter jejuni

IDP91058 (show subtarget assignments)	8	soluble	No	FTT_0468	56707610	surA	peptidyl-prolyl cis-trans isomerase (PPI...	473	virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...	Community Requests	1M5Y	19.5%	Francisella tularensis

IDP00798 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1368	57284523	kataA	catalase	473	Conserved Gene / Pathway	Phase 2: March 2008	2ISA	63.4%	Staphylococcus aureus	Cellular processes	Detoxification

IDP04541 (show subtarget assignments)	1	cloned	No	CPF_0674	110800675	purF	amidophosphoribosyltransferase [Clostrid...	473	conserved gene; putative drug target function;	Phase 4: April 2009	1AO0	44.6%	Clostridium perfringens	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP00744 (show subtarget assignments)	1	soluble	No	SACOL1563	57284661	lpdA	2-oxoisovalerate dehydrogenase, E3 compo...	473	Drug Target Function	Phase 2: March 2008	3URH	37%	Staphylococcus aureus	Energy metabolism	Amino acids and amines

IDP05527 (show subtarget assignments)	1	cloned	No	CD2600	126700220		putative carbon starvation [Clostridium ...	473	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP90184 (show subtarget assignments)	8	expressed	No	AAM13486.1	20153025	CPXV039 CDS	CPXV039 protein	473	ankyrin repeat protein	Community Requests	1N11	14.4%	Cowpox virus	conserved hypothetical proteins	0

IDP91598 (show subtarget assignments)	8	cloned	No	BAB33448	13359481	ECs0025	hypothetical protein [Escherichia coli O...	473	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP00534 (show subtarget assignments)	1	purified	No	YPO3367	16123517	cysG	siroheme synthase	472	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	52.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00481 (show subtarget assignments)	1	expressed	No	YPO3558	16123702	gltD	glutamate synthase subunit beta	472	Virulence Associated Factor	Phase 2: March 2008	2VDC	43.2%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP90774 (show subtarget assignments)	8	purified	No	Cj1197c	15792521	gatB	aspartyl/glutamyl-tRNA amidotransferase ...	472	Predicted Essential	Community Requests	3H0L	49.2%	Campylobacter jejuni

IDP04358 (show subtarget assignments)	1	cloned	No	YPO0895	115346679	creC	putative histidine kinase sensor [Yersin...	472	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	14.8%	Yersinia pestis	Regulatory functions	Other

IDP02234 (show subtarget assignments)	1	cloned	No	FTT1094c	56708177		cytosol aminopeptidase family protein [F...	471	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3IJ3	41.1%	Francisella tularensis	N/A	N/A

IDP05660 (show subtarget assignments)	1	cloned	No	lmo0239	16802285	cysS	cysteinyl-tRNA synthetase [Listeria mono...	446	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1LI5	43.7%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP91922 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100006235	298255189		pneumolysin (Thiol-activated cytolysin) ...	471	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1S3R	53.3%	Streptococcus pneumoniae

IDP90921 (show subtarget assignments)	8	purified	No	YPO2984	16123165	gltX	glutamyl-tRNA synthetase [Yersinia pesti...	471	Predicted Essential	Community Requests	2CFO	38.4%	Yersinia pestis

IDP02568 (show subtarget assignments)	1	cloned	No	GBAA0295	47525558	purF	amidophosphoribosyltransferase [Bacillus...	471	Drug target motif; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1AO0	69.9%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90737 (show subtarget assignments)	8	expressed	No	YPO2523	16122742	menE	O-succinylbenzoic acid--CoA ligase [Yers...	471	Predicted Essential	Community Requests	3NYQ	32.4%	Yersinia pestis

IDP92071 (show subtarget assignments)	8	selected	No	TGME49_011680	211968957		protein disulfide isomerase [Toxoplasma ...	471	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3F8U	33.5%	Toxoplasma gondii

IDP01196 (show subtarget assignments)	1	expressed	No	BA_1248	30255197	trpE	anthranilate synthase component I	471	Drug Target Function	Phase 2: March 2008	1QDL	38.4%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP04302 (show subtarget assignments)	1	soluble	No	CPF_2503	110801437		sensor histidine kinase [Clostridium per...	471	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.6%	Clostridium perfringens	Signal transduction	Two-component systems

IDP00533 (show subtarget assignments)	1	purified	No	YPO0158	16120501	cysG	siroheme synthase	470	Conserved Gene / Pathway	Phase 2: March 2008	1PJQ	70.2%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP04290 (show subtarget assignments)	1	cloned	No	YPO3099	218930141	manC	mannose-1-phosphate guanylyltransferase ...	470	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2CU2	28.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides

IDP04683 (show subtarget assignments)	1	expressed	No	GBAA3269	47528557		iron-sulfur cluster-binding protein [Bac...	470	virulence factor; putative drug target function;	Phase 4: April 2009			Bacillus anthracis	Energy metabolism	Electron transport

IDP91034 (show subtarget assignments)	8	selected	No	SDY_P055	82524461	ospC1	OspC1 [Shigella dysenteriae Sd197]	470	virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...	Community Requests			Shigella dysenteriae

IDP92100 (show subtarget assignments)	8	selected	No	TGME49_118430	237840969		malate dehydrogenase, putative [Toxoplas...	470	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3GVH	43.4%	Toxoplasma gondii

IDP04336 (show subtarget assignments)	8	in_crystallization_trials	No	CAC05790	12329059	ospC1	OspC1, secreted by the Mxi-Spa secretion...	470	Shigella effector protein	Community Requests			Shigella flexneri

IDP00714 (show subtarget assignments)	1	cloned	No	SACOL1198	57285941	ftsA	cell division protein FtsA	470	Drug Target Function	Phase 2: March 2008	1E4F	18.3%	Staphylococcus aureus	Cellular processes	Cell division

IDP02232 (show subtarget assignments)	1	expressed	No	FTT1050c	56708136	cysN	sulfate adenylate transferase subunit 1 ...	470	Drug Target	Phase 3: June 2008	1ZUN	56%	Francisella tularensis	Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo	Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP01954 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0812	15792150	thrC	threonine synthase [Campylobacter jejuni...	470	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1KL7	33.2%	Campylobacter jejuni	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02065 (show subtarget assignments)	1	in_pdb 3IAC	No	STM3137	16766437		glucuronate isomerase [Salmonella typhim...	470	Conserved; Drug target functions	Phase 3: June 2008	3IAC	100%	Salmonella enterica	Energy metabolism	Sugars

IDP91824 (show subtarget assignments)	8	cloned	No	b1676	1787965	pykF	pyruvate kinase I [Escherichia coli str....	470	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1PKY	99.8%	Escherichia coli

IDP01832 (show subtarget assignments)	1	expressed	No	GBAA5547	47530867	atpD	F0F1 ATP synthase subunit beta [Bacillus...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SKY	86.4%	Bacillus anthracis	Energy metabolism	ATP-proton motive force interconversion

IDP01804 (show subtarget assignments)	1	cloned	No	GBAA5414	47530727		carboxyl-terminal protease [Bacillus ant...	469	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FC6	19.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91200 (show subtarget assignments)	8	cloned	No	CD1911	115250958		two-component sensor histidine kinase [C...	469	virulence/pathogenesis / The important histidine kinase for ethanolamine utilization in anaerobic bacteri...	Community Requests			Clostridium difficile

IDP00805 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1801	57286235		dipeptidase PepV	469	Drug Target Function	Phase 2: March 2008	3KHX	100%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02226 (show subtarget assignments)	1	crystallized	No	GBAA0164	47525422	yqjI	6-phosphogluconate dehydrogenase [Bacill...	469	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2W8Z	72.3%	Bacillus anthracis	Energy metabolism	Pentose phosphate pathway

IDP05605 (show subtarget assignments)	1	cloned	No	BA_4978	30259470		collagen triple helix repeat domain prot...	469	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	27.7%	Bacillus anthracis	Unknown function: General

IDP01776 (show subtarget assignments)	1	expressed	No	STM0687	16764057	ybfM	putative outer membrane protein [Salmone...	468	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP00799 (show subtarget assignments)	1	expressed	No	SACOL1403	57284557	trpE	anthranilate synthase component I	468	Drug Target Function	Phase 2: March 2008	1QDL	33.3%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP00740 (show subtarget assignments)	1	cloned	No	SACOL1105	57285891	pdhD	dihydrolipoamide dehydrogenase	468	Drug Target Function	Phase 2: March 2008	1EBD	70.9%	Staphylococcus aureus	Energy metabolism	Pyruvate dehydrogenase

IDP91512 (show subtarget assignments)	8	cloned	No	VV2_0404	27366843		cytolysin [Vibrio vulnificus CMCP6]	468	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XEZ	25.9%	Vibrio vulnificus

IDP90297 (show subtarget assignments)	8	purified	No	TGME49_065450	211966338		hexokinase [Toxoplasma gondii ME49]	468	Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...	Community Requests	1CZA	34.7%	Toxoplasma gondii

IDP91340 (show subtarget assignments)	8	cloned	No	VV2_0102	27366559		di- and tricarboxylate transporter [Vibr...	467	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP00672 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1271	57286009	hslU	ATP-dependent protease ATP-binding subun...	467	Drug Target Function	Phase 2: March 2008	1G3I	47.1%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP90531 (show subtarget assignments)	8	cloned	No	Q9KSF9	20139940		RecName: Full=Asparaginyl-tRNA synthetas...	466	Predicted Essential	Community Requests	1X54	35.2%	Vibrio cholerae

IDP04667 (show subtarget assignments)	1	cloned	No	GBAA1313	47526578		sensor histidine kinase [Bacillus anthra...	466	putative drug target function;	Phase 4: April 2009	2C2A	15.2%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP05254 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0576	57651406	cysS	cysteinyl-tRNA synthetase [Staphylococcu...	466	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3TQO	45.4%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP02110 (show subtarget assignments)	1	expressed	No	STM3820	16767105		putative cytochrome c peroxidase [Salmon...	466	Conserved; Drug target functions	Phase 3: June 2008	1IQC	29.4%	Salmonella enterica	Cellular processes	Detoxification

IDP01939 (show subtarget assignments)	1	purified	No	STM4126	16767390	udhA	soluble pyridine nucleotide transhydroge...	466	Conserved; Drug target functions	Phase 3: June 2008	3URH	33%	Salmonella enterica	Energy metabolism	Pyruvate dehydrogenase

IDP05225 (show subtarget assignments)	1	cloned	No	lmo0415	16802459	-	hypothetical protein lmo0415 [Listeria m...	466	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	29%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90728 (show subtarget assignments)	8	cloned	No	YPO1412	16121692	asnC	asparaginyl-tRNA synthetase [Yersinia pe...	466	Predicted Essential	Community Requests	1X54	34.3%	Yersinia pestis

IDP01761 (show subtarget assignments)	1	cloned	No	GBAA5606	47530928		aminopeptidase, putative [Bacillus anthr...	466	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2EK8	33%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02213 (show subtarget assignments)	1	expressed	No	GBAA0068	47525322	pabB	para-aminobenzoate synthase component I ...	465	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1QDL	37.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP01935 (show subtarget assignments)	1	expressed	No	CBU_0136	29540756	murC	UDP-N-acetylmuramate--alanine ligase [Co...	465	Conserved; Drug target functions	Phase 3: June 2008	2F00	47.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04578 (show subtarget assignments)	1	cloned	No	BAS0089	49183123		cysteinyl-tRNA synthetase [Bacillus anth...	465	Proposed to be essential proteins	Phase 4: April 2009	1LI5	45.6%	Bacillus anthracis

IDP00220 (show subtarget assignments)	1	purified	No	YPO2855	16123048	-	putative protease	464	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01354 (show subtarget assignments)	1	cloned	No	VC0003	15640035	trmE	tRNA modification GTPase TrmE	464	Conserved Gene / Pathway	Phase 2: March 2008	3GEH	37.9%	Vibrio cholerae	Cellular processes	Detoxification

IDP02652 (show subtarget assignments)	1	expressed	No	GBAA1422	47526694	leuC	isopropylmalate isomerase large subunit ...	464	Conserved; Drug target functions	Phase 3: June 2008	2B3X	22%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP01232 (show subtarget assignments)	1	purified	No	BA_5112	30259596	menF	menaquinone-specific isochorismate synth...	464	Drug Target Function	Phase 2: March 2008	3H9M	22.2%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02169 (show subtarget assignments)	1	soluble	No	FTT0306	56707459	fumC	fumarate hydratase [Francisella tularens...	463	Conserved; Drug target functions	Phase 3: June 2008	3E04	55.3%	Francisella tularensis	Energy metabolism	TCA cycle

IDP05339 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1622	57651958	glyS	glycyl-tRNA synthetase [Staphylococcus a...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	41.9%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05569 (show subtarget assignments)	1	soluble	No	BAS4454	49187449	-	asparaginyl-tRNA synthetase [Bacillus an...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	35.9%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP90976 (show subtarget assignments)	8	cloned	No	y0137	22124057	degQ	protease [Yersinia pestis KIM 10]	463	other biological interest / bifunctional chaperone / protease	Community Requests	4A8A	67.6%	Yersinia pestis

IDP04470 (show subtarget assignments)	1	cloned	No	YPO2306	218929398		putative amino acid antiporter [Yersinia...	463	putative drug target function;	Phase 4: April 2009	3HQK	26.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP04542 (show subtarget assignments)	1	expressed	No	YPO2000	218929110		putative two-component system sensor pro...	463	putative drug target function;	Phase 4: April 2009	3JZ3	13.2%	Yersinia pestis	Regulatory functions	Other

IDP04662 (show subtarget assignments)	1	cloned	No	GBAA0650	47525929		sensor histidine kinase [Bacillus anthra...	463	putative drug target function;	Phase 4: April 2009	2C2A	17.9%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP92077 (show subtarget assignments)	8	selected	No	TGME49_097370	237843739		ruvB-like 1, putative [Toxoplasma gondii...	463	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2C9O	62.9%	Toxoplasma gondii

IDP91723 (show subtarget assignments)	8	selected	No	NP_112552	14165435	HNRNPK	heterogeneous nuclear ribonucleoprotein ...	463	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1J5K	18.6%	Homo sapiens

IDP05766 (show subtarget assignments)	1	expressed	No	S0723	30040469		putative helicase [Shigella flexneri 2a ...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2R6A	31.7%	Shigella flexneri	DNA metabolism: DNA replication, recombination, and repair

IDP02473 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA3967	47529257	hslU	ATP-dependent protease ATP-binding subun...	463	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1E94	50.8%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP90662 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1288c	15792611	gltX	glutamyl-tRNA synthetase [Campylobacter ...	463	Predicted Essential	Community Requests	2CFO	38.9%	Campylobacter jejuni

IDP00316 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP02725 (show subtarget assignments)	1	crystallized	No	GBAA4341	47529638	bioA	adenosylmethionine--8-amino-7-oxononanoa...	462	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DOD	57.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02471 (show subtarget assignments)	1	cloned	No	lmo0880	16802921		hypothetical protein lmo0880 [Listeria m...	462	Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...	Phase 3: June 2008	1N67	18.2%	Listeria monocytogenes	Cell envelope	Other

IDP04472 (show subtarget assignments)	1	selected	No	YPO2479	115348179	manB	phosphomannomutase [Yersinia pestis CO92...	462	drug target; putative drug target function;	Phase 4: April 2009	3UW2	35.6%	Yersinia pestis	Energy metabolism	Sugars

IDP01530 (show subtarget assignments)	1	in_pdb 3EFV 3ETF	No	STM1524	16764869	yneI	putative succinate-semialdehyde dehydrog...	462	It is an essential gene in Salmonella which is important in energy metabolism.	Phase 3: June 2008	3EFV	100%	Salmonella enterica

IDP04429 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4879	47530172	argH-2	argininosuccinate lyase [Bacillus anthra...	462	conserved gene; putative drug target function;	Phase 4: April 2009	2E9F	48.3%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02662 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1676	16803716	menF	menaquinone-specific isochorismate synth...	462	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3HWO	23.6%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP90741 (show subtarget assignments)	8	soluble	No	Cj0802	15792140	cysS	cysteinyl-tRNA synthetase [Campylobacter...	462	Predicted Essential	Community Requests	3TQO	40%	Campylobacter jejuni

IDP02097 (show subtarget assignments)	1	cloned	No	Cj0195	15791582	fliI	flagellum-specific ATP synthase [Campylo...	461	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	2DPY	40.3%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP00908 (show subtarget assignments)	1	expressed	No	STM0143	16763533	hofB	hypothetical protein STM0143	461	Conserved Gene / Pathway	Phase 2: March 2008	1P9R	37.3%	Salmonella enterica	Cell envelope	Surface structures

IDP90096
(show subtarget assignments)

8

expressed

No

ZZZ_0012

476

This protein is a component of a type VI secretion system of enteroaggregative E...

Community Requests

Escherichia coli

IDP90633
(show subtarget assignments)

8

cloned

No

VC1971

15641973

O-succinylbenzoic acid--CoA ligase [Vibr...

476

Predicted Essential

Community Requests

2QVX

27.9%

Vibrio cholerae

IDP01874
(show subtarget assignments)

1

cloned

No

GBAA0062

47525316

hypothetical protein GBAA0062 [Bacillus ...

476

Conserved;

Phase 3: June 2008

3A2K

46.6%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04255
(show subtarget assignments)

1

cloned

No

CPF_1922

110799469

purB

adenylosuccinate lyase [Clostridium perf...

476

conserved gene; putative drug target function;

Phase 4: April 2009

2J91

56.5%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90001
(show subtarget assignments)

8

cloned

No

FTT0094c

56603762

qseC

sensor histidine kinase

475

Drug Target (Community Request)

Community Requests

3A0R

15.8%

Francisella tularensis

IDP01889
(show subtarget assignments)

1

soluble

No

STM0209

16763599

htrA

serine endoprotease [Salmonella typhimur...

475

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2ZLE

87.6%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04468
(show subtarget assignments)

1

cloned

No

YPO2205

115347912

trpC

tryptophan biosynthesis protein TrpCF [Y...

475

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

1PII

69.3%

Yersinia pestis

Amino acid biosynthesis

Aromatic amino acid family

IDP04238
(show subtarget assignments)

1

cloned

No

CPF_0889

110799788

sensor histidine kinase [Clostridium per...

475

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Signal transduction

Two-component systems

IDP05068
(show subtarget assignments)

1

soluble

No

CD2735

126700350

cell surface protein [Clostridium diffic...

475

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KQ8

5.5%

Clostridium difficile

Cell envelope: Other

IDP90296
(show subtarget assignments)

8

purified

No

TGME49_068850

211963242

enolase 2 [Toxoplasma gondii ME49]

475

Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...

Community Requests

3OTR

68.8%

Toxoplasma gondii

IDP05104
(show subtarget assignments)

1

cloned

No

CD1233

126698829

cell surface protein [Clostridium diffic...

475

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP01169
(show subtarget assignments)

1

cloned

No

GBAA_pXO1_0146

47566458

atxA

transcriptional activator atxa, (pxo1-11...

475

Virulence Associated Factor

Phase 2: March 2008

3SQN

20.4%

Bacillus anthracis

IDP00590
(show subtarget assignments)

1

cloned

No

YPO1078

16121379

mltD

predicted membrane-bound lytic murein tr...

475

Drug Target Function

Phase 2: March 2008

1E0G

7.8%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91813
(show subtarget assignments)

8

soluble

No

b0116

1786307

lpd

lipoamide dehydrogenase, E3 component is...

474

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1BHY

63.6%

Escherichia coli

IDP00969
(show subtarget assignments)

1

purified

No

STM1597

161353598

ydcW

putative aldehyde dehydrogenase

474

Conserved Gene / Pathway

Phase 2: March 2008

1WNB

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP00435
(show subtarget assignments)

1

purified

No

YPO0673

16120998

sufI

repressor protein for FtsI

474

Conserved Gene / Pathway

Phase 2: March 2008

2UXT

69.6%

Yersinia pestis

Cellular processes

Cell division

IDP00010
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2144

30256791

uroporphyrin-III C-methyltransferase, pu...

474

Drug Target Homolog

Phase 1: October 2007

1PJQ

24.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90858
(show subtarget assignments)

8

in_crystallization_trials

No

O31153

30179879

Glutamyl-tRNA synthetase (Glutamate--tRN...

474

Predicted Essential

Community Requests

2CFO

40.2%

Vibrio cholerae

IDP90786
(show subtarget assignments)

8

cloned

No

Cj1385

15792708

katA

catalase [Campylobacter jejuni subsp. je...

474

Predicted Essential

Community Requests

2ISA

57.8%

Campylobacter jejuni

IDP91058
(show subtarget assignments)

8

soluble

No

FTT_0468

56707610

surA

peptidyl-prolyl cis-trans isomerase (PPI...

473

virulence/pathogenesis / Gene encodes a SurA orthologue which has shown to be important for virulence in ...

Community Requests

1M5Y

19.5%

Francisella tularensis

IDP00798
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1368

57284523

kataA

catalase

473

Conserved Gene / Pathway

Phase 2: March 2008

2ISA

63.4%

Staphylococcus aureus

Cellular processes

Detoxification

IDP04541
(show subtarget assignments)

1

cloned

No

CPF_0674

110800675

purF

amidophosphoribosyltransferase [Clostrid...

473

conserved gene; putative drug target function;

Phase 4: April 2009

1AO0

44.6%

Clostridium perfringens

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP00744
(show subtarget assignments)

1

soluble

No

SACOL1563

57284661

lpdA

2-oxoisovalerate dehydrogenase, E3 compo...

473

Drug Target Function

Phase 2: March 2008

3URH

37%

Staphylococcus aureus

Energy metabolism

Amino acids and amines

IDP05527
(show subtarget assignments)

1

cloned

No

CD2600

126700220

putative carbon starvation [Clostridium ...

473

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP90184
(show subtarget assignments)

8

expressed

No

AAM13486.1

20153025

CPXV039 CDS

CPXV039 protein

473

ankyrin repeat protein

Community Requests

1N11

14.4%

Cowpox virus

conserved hypothetical proteins

0

IDP91598
(show subtarget assignments)

8

cloned

No

BAB33448

13359481

ECs0025

hypothetical protein [Escherichia coli O...

473

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP00534
(show subtarget assignments)

1

purified

No

YPO3367

16123517

cysG

siroheme synthase

472

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

52.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00481
(show subtarget assignments)

1

expressed

No

YPO3558

16123702

gltD

glutamate synthase subunit beta

472

Virulence Associated Factor

Phase 2: March 2008

2VDC

43.2%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP90774
(show subtarget assignments)

8

purified

No

Cj1197c

15792521

gatB

aspartyl/glutamyl-tRNA amidotransferase ...

472

Predicted Essential

Community Requests

3H0L

49.2%

Campylobacter jejuni

IDP04358
(show subtarget assignments)

1

cloned

No

YPO0895

115346679

creC

putative histidine kinase sensor [Yersin...

472

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

14.8%

Yersinia pestis

Regulatory functions

Other

IDP02234
(show subtarget assignments)

1

cloned

No

FTT1094c

56708177

cytosol aminopeptidase family protein [F...

471

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3IJ3

41.1%

Francisella tularensis

N/A

IDP05660
(show subtarget assignments)

1

cloned

No

lmo0239

16802285

cysS

cysteinyl-tRNA synthetase [Listeria mono...

446

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1LI5

43.7%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP91922
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100006235

298255189

pneumolysin (Thiol-activated cytolysin) ...

471

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1S3R

53.3%

Streptococcus pneumoniae

IDP90921
(show subtarget assignments)

8

purified

No

YPO2984

16123165

gltX

glutamyl-tRNA synthetase [Yersinia pesti...

471

Predicted Essential

Community Requests

2CFO

38.4%

Yersinia pestis

IDP02568
(show subtarget assignments)

1

cloned

No

GBAA0295

47525558

purF

amidophosphoribosyltransferase [Bacillus...

471

Drug target motif; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1AO0

69.9%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90737
(show subtarget assignments)

8

expressed

No

YPO2523

16122742

menE

O-succinylbenzoic acid--CoA ligase [Yers...

471

Predicted Essential

Community Requests

3NYQ

32.4%

Yersinia pestis

IDP92071
(show subtarget assignments)

8

selected

No

TGME49_011680

211968957

protein disulfide isomerase [Toxoplasma ...

471

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3F8U

33.5%

Toxoplasma gondii

IDP01196
(show subtarget assignments)

1

expressed

No

BA_1248

30255197

trpE

anthranilate synthase component I

471

Drug Target Function

Phase 2: March 2008

1QDL

38.4%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP04302
(show subtarget assignments)

1

soluble

No

CPF_2503

110801437

sensor histidine kinase [Clostridium per...

471

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.6%

Clostridium perfringens

Signal transduction

Two-component systems

IDP00533
(show subtarget assignments)

1

purified

No

YPO0158

16120501

cysG

siroheme synthase

470

Conserved Gene / Pathway

Phase 2: March 2008

1PJQ

70.2%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP04290
(show subtarget assignments)

1

cloned

No

YPO3099

218930141

manC

mannose-1-phosphate guanylyltransferase ...

470

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2CU2

28.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

IDP04683
(show subtarget assignments)

1

expressed

No

GBAA3269

47528557

iron-sulfur cluster-binding protein [Bac...

470

virulence factor; putative drug target function;

Phase 4: April 2009

Bacillus anthracis

Energy metabolism

Electron transport

IDP91034
(show subtarget assignments)

8

selected

No

SDY_P055

82524461

ospC1

OspC1 [Shigella dysenteriae Sd197]

470

virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...

Community Requests

Shigella dysenteriae

IDP92100
(show subtarget assignments)

8

selected

No

TGME49_118430

237840969

malate dehydrogenase, putative [Toxoplas...

470

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3GVH

43.4%

Toxoplasma gondii

IDP04336
(show subtarget assignments)

8

in_crystallization_trials

No

CAC05790

12329059

ospC1

OspC1, secreted by the Mxi-Spa secretion...

470

Shigella effector protein

Community Requests

Shigella flexneri

IDP00714
(show subtarget assignments)

1

cloned

No

SACOL1198

57285941

ftsA

cell division protein FtsA

470

Drug Target Function

Phase 2: March 2008

1E4F

18.3%

Staphylococcus aureus

Cellular processes

Cell division

IDP02232
(show subtarget assignments)

1

expressed

No

FTT1050c

56708136

cysN

sulfate adenylate transferase subunit 1 ...

470

Drug Target

Phase 3: June 2008

1ZUN

56%

Francisella tularensis

Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo

Serine familySulfur metabolism,Purine ribonucleotide biosynthesis

IDP01954
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0812

15792150

thrC

threonine synthase [Campylobacter jejuni...

470

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1KL7

33.2%

Campylobacter jejuni

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02065
(show subtarget assignments)

1

in_pdb
3IAC

No

STM3137

16766437

glucuronate isomerase [Salmonella typhim...

470

Conserved; Drug target functions

Phase 3: June 2008

3IAC

100%

Salmonella enterica

Energy metabolism

Sugars

IDP91824
(show subtarget assignments)

8

cloned

No

b1676

1787965

pykF

pyruvate kinase I [Escherichia coli str....

470

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1PKY

99.8%

Escherichia coli

IDP01832
(show subtarget assignments)

1

expressed

No

GBAA5547

47530867

atpD

F0F1 ATP synthase subunit beta [Bacillus...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SKY

86.4%

Bacillus anthracis

Energy metabolism

ATP-proton motive force interconversion

IDP01804
(show subtarget assignments)

1

cloned

No

GBAA5414

47530727

carboxyl-terminal protease [Bacillus ant...

469

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FC6

19.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91200
(show subtarget assignments)

8

cloned

No

CD1911

115250958

two-component sensor histidine kinase [C...

469

virulence/pathogenesis / The important histidine kinase for ethanolamine utilization in anaerobic bacteri...

Community Requests

Clostridium difficile

IDP00805
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1801

57286235

dipeptidase PepV

469

Drug Target Function

Phase 2: March 2008

3KHX

100%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02226
(show subtarget assignments)

1

crystallized

No

GBAA0164

47525422

yqjI

6-phosphogluconate dehydrogenase [Bacill...

469

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2W8Z

72.3%

Bacillus anthracis

Energy metabolism

Pentose phosphate pathway

IDP05605
(show subtarget assignments)

1

cloned

No

BA_4978

30259470

collagen triple helix repeat domain prot...

469

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

27.7%

Bacillus anthracis

Unknown function: General

IDP01776
(show subtarget assignments)

1

expressed

No

STM0687

16764057

ybfM

putative outer membrane protein [Salmone...

468

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP00799
(show subtarget assignments)

1

expressed

No

SACOL1403

57284557

trpE

anthranilate synthase component I

468

Drug Target Function

Phase 2: March 2008

1QDL

33.3%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP00740
(show subtarget assignments)

1

cloned

No

SACOL1105

57285891

pdhD

dihydrolipoamide dehydrogenase

468

Drug Target Function

Phase 2: March 2008

1EBD

70.9%

Staphylococcus aureus

Energy metabolism

Pyruvate dehydrogenase

IDP91512
(show subtarget assignments)

8

cloned

No

VV2_0404

27366843

cytolysin [Vibrio vulnificus CMCP6]

468

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XEZ

25.9%

Vibrio vulnificus

IDP90297
(show subtarget assignments)

8

purified

No

TGME49_065450

211966338

hexokinase [Toxoplasma gondii ME49]

468

Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...

Community Requests

1CZA

34.7%

Toxoplasma gondii

IDP91340
(show subtarget assignments)

8

cloned

No

VV2_0102

27366559

di- and tricarboxylate transporter [Vibr...

467

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP00672
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1271

57286009

hslU

ATP-dependent protease ATP-binding subun...

467

Drug Target Function

Phase 2: March 2008

1G3I

47.1%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP90531
(show subtarget assignments)

8

cloned

No

Q9KSF9

20139940

RecName: Full=Asparaginyl-tRNA synthetas...

466

Predicted Essential

Community Requests

1X54

35.2%

Vibrio cholerae

IDP04667
(show subtarget assignments)

1

cloned

No

GBAA1313

47526578

sensor histidine kinase [Bacillus anthra...

466

putative drug target function;

Phase 4: April 2009

2C2A

15.2%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP05254
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0576

57651406

cysS

cysteinyl-tRNA synthetase [Staphylococcu...

466

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3TQO

45.4%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP02110
(show subtarget assignments)

1

expressed

No

STM3820

16767105

putative cytochrome c peroxidase [Salmon...

466

Conserved; Drug target functions

Phase 3: June 2008

1IQC

29.4%

Salmonella enterica

Cellular processes

Detoxification

IDP01939
(show subtarget assignments)

1

purified

No

STM4126

16767390

udhA

soluble pyridine nucleotide transhydroge...

466

Conserved; Drug target functions

Phase 3: June 2008

3URH

33%

Salmonella enterica

Energy metabolism

Pyruvate dehydrogenase

IDP05225
(show subtarget assignments)

1

cloned

No

lmo0415

16802459

-

hypothetical protein lmo0415 [Listeria m...

466

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

29%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90728
(show subtarget assignments)

8

cloned

No

YPO1412

16121692

asnC

asparaginyl-tRNA synthetase [Yersinia pe...

466

Predicted Essential

Community Requests

1X54

34.3%

Yersinia pestis

IDP01761
(show subtarget assignments)

1

cloned

No

GBAA5606

47530928

aminopeptidase, putative [Bacillus anthr...

466

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2EK8

33%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02213
(show subtarget assignments)

1

expressed

No

GBAA0068

47525322

pabB

para-aminobenzoate synthase component I ...

465

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1QDL

37.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP01935
(show subtarget assignments)

1

expressed

No

CBU_0136

29540756

murC

UDP-N-acetylmuramate--alanine ligase [Co...

465

Conserved; Drug target functions

Phase 3: June 2008

2F00

47.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04578
(show subtarget assignments)

1

cloned

No

BAS0089

49183123

cysteinyl-tRNA synthetase [Bacillus anth...

465

Proposed to be essential proteins

Phase 4: April 2009

1LI5

45.6%

Bacillus anthracis

IDP00220
(show subtarget assignments)

1

purified

No

YPO2855

16123048

-

putative protease

464

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01354
(show subtarget assignments)

1

cloned

No

VC0003

15640035

trmE

tRNA modification GTPase TrmE

464

Conserved Gene / Pathway

Phase 2: March 2008

3GEH

37.9%

Vibrio cholerae

Cellular processes

Detoxification

IDP02652
(show subtarget assignments)

1

expressed

No

GBAA1422

47526694

leuC

isopropylmalate isomerase large subunit ...

464

Conserved; Drug target functions

Phase 3: June 2008

2B3X

22%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP01232
(show subtarget assignments)

1

purified

No

BA_5112

30259596

menF

menaquinone-specific isochorismate synth...

464

Drug Target Function

Phase 2: March 2008

3H9M

22.2%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02169
(show subtarget assignments)

1

soluble

No

FTT0306

56707459

fumC

fumarate hydratase [Francisella tularens...

463

Conserved; Drug target functions

Phase 3: June 2008

3E04

55.3%

Francisella tularensis

Energy metabolism

TCA cycle

IDP05339
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1622

57651958

glyS

glycyl-tRNA synthetase [Staphylococcus a...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

41.9%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05569
(show subtarget assignments)

1

soluble

No

BAS4454

49187449

-

asparaginyl-tRNA synthetase [Bacillus an...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

35.9%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP90976
(show subtarget assignments)

8

cloned

No

y0137

22124057

degQ

protease [Yersinia pestis KIM 10]

463

other biological interest / bifunctional chaperone / protease

Community Requests

4A8A

67.6%

Yersinia pestis

IDP04470
(show subtarget assignments)

1

cloned

No

YPO2306

218929398

putative amino acid antiporter [Yersinia...

463

putative drug target function;

Phase 4: April 2009

3HQK

26.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP04542
(show subtarget assignments)

1

expressed

No

YPO2000

218929110

putative two-component system sensor pro...

463

putative drug target function;

Phase 4: April 2009

3JZ3

13.2%

Yersinia pestis

Regulatory functions

Other

IDP04662
(show subtarget assignments)

1

cloned

No

GBAA0650

47525929

sensor histidine kinase [Bacillus anthra...

463

putative drug target function;

Phase 4: April 2009

2C2A

17.9%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP92077
(show subtarget assignments)

8

selected

No

TGME49_097370

237843739

ruvB-like 1, putative [Toxoplasma gondii...

463

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2C9O

62.9%

Toxoplasma gondii

IDP91723
(show subtarget assignments)

8

selected

No

NP_112552

14165435

HNRNPK

heterogeneous nuclear ribonucleoprotein ...

463

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1J5K

18.6%

Homo sapiens

IDP05766
(show subtarget assignments)

1

expressed

No

S0723

30040469

putative helicase [Shigella flexneri 2a ...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2R6A

31.7%

Shigella flexneri

DNA metabolism: DNA replication, recombination, and repair

IDP02473
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA3967

47529257

hslU

ATP-dependent protease ATP-binding subun...

463

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1E94

50.8%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP90662
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1288c

15792611

gltX

glutamyl-tRNA synthetase [Campylobacter ...

463

Predicted Essential

Community Requests

2CFO

38.9%

Campylobacter jejuni

IDP00316
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP02725
(show subtarget assignments)

1

crystallized

No

GBAA4341

47529638

bioA

adenosylmethionine--8-amino-7-oxononanoa...

462

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DOD

57.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02471
(show subtarget assignments)

1

cloned

No

lmo0880

16802921

hypothetical protein lmo0880 [Listeria m...

462

Predicted involvement in glycosyl group metabolism; Predicted involvement or loc...

Phase 3: June 2008

1N67

18.2%

Listeria monocytogenes

Cell envelope

Other

IDP04472
(show subtarget assignments)

1

selected

No

YPO2479

115348179

manB

phosphomannomutase [Yersinia pestis CO92...

462

drug target; putative drug target function;

Phase 4: April 2009

3UW2

35.6%

Yersinia pestis

Energy metabolism

Sugars

IDP01530
(show subtarget assignments)

1

in_pdb
3EFV
3ETF

No

STM1524

16764869

yneI

putative succinate-semialdehyde dehydrog...

462

It is an essential gene in Salmonella which is important in energy metabolism.

Phase 3: June 2008

3EFV

100%

Salmonella enterica

IDP04429
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4879

47530172

argH-2

argininosuccinate lyase [Bacillus anthra...

462

conserved gene; putative drug target function;

Phase 4: April 2009

2E9F

48.3%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02662
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1676

16803716

menF

menaquinone-specific isochorismate synth...

462

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3HWO

23.6%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP90741
(show subtarget assignments)

8

soluble

No

Cj0802

15792140

cysS

cysteinyl-tRNA synthetase [Campylobacter...

462

Predicted Essential

Community Requests

3TQO

40%

Campylobacter jejuni

IDP02097
(show subtarget assignments)

1

cloned

No

Cj0195

15791582

fliI

flagellum-specific ATP synthase [Campylo...

461

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

2DPY

40.3%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP00908
(show subtarget assignments)

1

expressed

No

STM0143

16763533

hofB

hypothetical protein STM0143

461

Conserved Gene / Pathway

Phase 2: March 2008

1P9R

37.3%

Salmonella enterica

Cell envelope

Surface structures