Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91244 (show subtarget assignments)	8	soluble	No	HP0663	0			365	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1UM0	100%	Helicobacter pylori	Amino acid biosynthesis: Aromatic amino acid family

IDP04231 (show subtarget assignments)	1	purified	No	CPF_0690	110800421	aroC	chorismate synthase [Clostridium perfrin...	357	conserved gene; putative drug target function;	Phase 4: April 2009	1UM0	39.8%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP00338 (show subtarget assignments)	1	cloned	No	FTT0876c	56707980	aroC	chorismate synthase	352	Drug Target Function	Phase 2: March 2008	1UM0	47.4%	Francisella tularensis	Amino acid biosynthesis	Aromatic amino acid family

IDP02745 (show subtarget assignments)	1	cloned	No	GBAA4384	47529679	bfmbAa	3-methyl-2-oxobutanoate dehydrogenase, a...	333	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	41.7%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02743 (show subtarget assignments)	1	cloned	No	GBAA4383	47529678	bfmbAb	3-methyl-2-oxobutanoate dehydrogenase, b...	327	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1UM9	52.9%	Bacillus anthracis	Energy metabolism	Amino acids and amines

IDP02125 (show subtarget assignments)	1	cloned	No	STM4453	16767699	treC	trehalose-6-phosphate hydrolase [Salmone...	550	Conserved; Drug target functions	Phase 3: June 2008	1UOK	44.7%	Salmonella enterica	Energy metabolism	Other

IDP05215 (show subtarget assignments)	1	cloned	No	CD3091	126700708	treA	trehalose-6-phosphate hydrolase [Clostri...	555	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1UOK	50.2%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05181 (show subtarget assignments)	1	soluble	No	BA_4729	30259221		bacterial extracellular solute-binding p...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1UQW	30.3%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP04377 (show subtarget assignments)	1	soluble	No	CPF_2652	110798678		putative maltose/maltodextrin ABC transp...	408	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1URG	38.7%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01008 (show subtarget assignments)	1	soluble	No	STM2533	16765853	sseA	3-mercaptopyruvate sulfurtransferase	280	Conserved Gene / Pathway	Phase 2: March 2008	1URH	79.6%	Salmonella enterica	Cellular processes	Detoxification

IDP00258 (show subtarget assignments)	1	in_crystallization_trials	No	MMLVgp1	22550316		Montana myotis leukoencephalitis Envelop...	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.6%	Montana myotis

IDP00256 (show subtarget assignments)	1	expressed	No	RBVgp1	21397175		Rio Bravo bat virus Envelope protein	395	Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...	Phase 1: October 2007	1URZ	43.2%	Rio Bravo

IDP00475 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3808	16123942	livK	branched-chain amino acid-binding protei...	371	Virulence Associated Factor	Phase 2: March 2008	1USG	71.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00473 (show subtarget assignments)	1	cloned	No	YPO0107	16120454	ftsN	cell division protein FtsN	281	Conserved Gene / Pathway	Phase 2: March 2008	1UTA	15.3%	Yersinia pestis	Cellular processes	Cell division

IDP01686 (show subtarget assignments)	1	cloned	No	Cj0804	15792142	pyrD	dihydroorotate dehydrogenase 2 [Campylob...	352	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1UUM	40.3%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP04154 (show subtarget assignments)	1	cloned	No	YPO4017	218931008	hutU	urocanate hydratase [Yersinia pestis CO9...	563	conserved gene; putative drug target function;	Phase 4: April 2009	1UWL	86.3%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP00686 (show subtarget assignments)	1	purified	No	SACOL2029	57284899	cscA	sucrose-6-phosphate hydrolase	494	Drug Target Function	Phase 2: March 2008	1UYP	29.8%	Staphylococcus aureus	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP02039 (show subtarget assignments)	1	expressed	No	YPO1198	16121491		putative ABC transport ATP-binding subun...	312	Conserved; CD; Drug target functions	Phase 3: June 2008	1V43	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00988 (show subtarget assignments)	1	expressed	No	STM2163	16765493	yehX	putative ABC-type proline/glycine betain...	315	Conserved Gene / Pathway	Phase 2: March 2008	1V43	32.4%	Salmonella enterica	Transport and binding proteins	Other

IDP01902 (show subtarget assignments)	1	soluble	No	STM0878	16764240	potG	putrescine transporter ATP-binding subun...	377	Conserved; Drug target functions	Phase 3: June 2008	1V43	38.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01341 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0687	15601444	fbpC	ferric transporter ATP-binding subunit	351	Conserved Gene / Pathway	Phase 2: March 2008	1V43	38.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02608 (show subtarget assignments)	1	expressed	No	CBU_0178	29540794		ABC transporter, ATP-binding protein [Co...	252	Conserved; Drug target functions	Phase 3: June 2008	1V43	43.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01922 (show subtarget assignments)	1	expressed	No	GBAA1441	47526716	sat	sulfate adenylyltransferase [Bacillus an...	378	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1V47	39.4%	Bacillus anthracis	Central intermediary metabolism	Sulfur metabolism

IDP01920 (show subtarget assignments)	1	expressed	No	CBU_1156	29541728	trpA	tryptophan synthase, alpha subunit [Coxi...	267	Conserved; Drug target functions	Phase 3: June 2008	1V7Y	35.6%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP00464 (show subtarget assignments)	1	purified	No	YPO2522	16122741		hypothetical protein YPO2522	319	Drug Target Function	Phase 2: March 2008	1V8G	24.5%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90720 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0348	15791716	trpB	tryptophan synthase subunit beta [Campyl...	392	Predicted Essential	Community Requests	1V8Z	51.5%	Campylobacter jejuni

IDP00302 (show subtarget assignments)	1	expressed	No	CBU_1155	29654460	trpBF	N-(5'phosphoribosyl)anthranilate isomera...	600	Drug Target Function	Phase 2: March 2008	1V8Z	38%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP90670 (show subtarget assignments)	8	soluble	No	Cj1202	15792526	metF	5,10-methylenetetrahydrofolate reductase...	282	Predicted Essential	Community Requests	1V93	34%	Campylobacter jejuni

IDP04648 (show subtarget assignments)	1	selected	No	FTT1245	56708307	rluD	ribosomal large subunit pseudouridine sy...	332	drug target; conserved gene;	Phase 4: April 2009	1V9F	43.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP90958 (show subtarget assignments)	8	cloned	No	UTI89_C1702	122423767		Hypothetical protein	807	C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...	Community Requests	1V9Y	18%	Escherichia coli

IDP00778 (show subtarget assignments)	1	cloned	No	SACOL0668	57284264		hydrolase, alpha/beta hydrolase fold fam...	266	Drug Target Function	Phase 2: March 2008	1VA4	26.1%	Staphylococcus aureus	Unknown function	Enzymes of unknown specificity

IDP00901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0004	16763394	thrC	threonine synthase	428	Conserved Gene / Pathway	Phase 2: March 2008	1VB3	93.5%	Salmonella enterica	Amino acid biosynthesis	Aspartate family

IDP02201 (show subtarget assignments)	1	soluble	No	YPO0461	16120790	thrC	threonine synthase [Yersinia pestis CO92...	429	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1VB3	82.3%	Yersinia pestis	Amino acid biosynthesis	Aspartate family

IDP02131 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1419c	15792737		methyltransferase [Campylobacter jejuni ...	253	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	1VE3	18.2%	Campylobacter jejuni	Cell envelope	Other

IDP91265 (show subtarget assignments)	8	cloned	No	NT05BA1551	49178367		2-heptaprenyl-1,4-naphthoquinone methylt...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VE3	24.9%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP02142 (show subtarget assignments)	1	cloned	No	CBU_0754	29541354		efflux transporter, RND family, MFP subu...	348	Conserved; Drug target functions	Phase 3: June 2008	1VF7	24.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP04483 (show subtarget assignments)	1	expressed	No	YPO3361	115348990	b2747	4-diphosphocytidyl-2C-methyl-D-erythrito...	241	conserved gene; putative drug target function;	Phase 4: April 2009	1VGT	63.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90706 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1048c	15792375	dapE	succinyl-diaminopimelate desuccinylase [...	365	Predicted Essential	Community Requests	1VGY	39%	Campylobacter jejuni

IDP00947 (show subtarget assignments)	1	purified	No	STM0988	16764348	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	248	Essential Gene	Phase 2: March 2008	1VH1	94%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91094 (show subtarget assignments)	8	cloned	No	APL_0085	126096365	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	250	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	1VH3	70.6%	Actinobacillus pleuropneumoniae

IDP92138 (show subtarget assignments)	8	selected	No	TGME49_073450	237833297		sufB/sufD domain-containing protein [Tox...	1267	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1VH4	3.3%	Toxoplasma gondii

IDP91006 (show subtarget assignments)	8	soluble	No	y1937	22125829		cysteine desulfurase activator complex s...	441	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	1VH4	56%	Yersinia pestis

IDP05120 (show subtarget assignments)	1	in_crystallization_trials	No	CD0236	126697807	fliS2	flagellar protein [Clostridium difficile...	116	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VH6	26.7%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05188 (show subtarget assignments)	1	purified	No	CD0235	126697806	fliS1	flagellar protein FliS [Clostridium diff...	131	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VH6	29.8%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02254 (show subtarget assignments)	1	cloned	No	FTT0766	56707880	deoD	purine nucleoside phosphorylase [Francis...	240	Drug Target	Phase 3: June 2008	1VHJ	43.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02534 (show subtarget assignments)	1	cloned	No	GBAA4614	47529912		Holliday junction resolvase-like protein...	137	Conserved;	Phase 3: June 2008	1VHX	70.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP04608 (show subtarget assignments)	1	soluble	No	BAS3704	49186703		putative glycerol-3-phosphate acyltransf...	330	Proposed to be essential proteins	Phase 4: April 2009	1VI1	66.4%	Bacillus anthracis

IDP90814 (show subtarget assignments)	8	soluble	No	Cj0329c	15791697	plsX	putative glycerol-3-phosphate acyltransf...	328	Predicted Essential	Community Requests	1VI1	38.4%	Campylobacter jejuni

IDP05324 (show subtarget assignments)	1	cloned	No	CD3431	126701054		putative cobalamin biosynthesis kinase [...	295	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VIS	24.7%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00195 (show subtarget assignments)	1	cloned	No	YPO1009	16121311	-	probable peptidase	410	Similar to Essential SALTY	Phase 1: October 2007	1VIX	38%	Yersinia pestis	Hypothetical proteins	Conserved

IDP01483 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0180	15600950		peptidase T	410	Drug Target Function	Phase 2: March 2008	1VIX	57.6%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02040 (show subtarget assignments)	1	expressed	No	GBAA4637	47529935	relA	GTP pyrophosphokinase [Bacillus anthraci...	727	CONSERVED. Additional information: It is responsible for a down-regulation of RN...	Phase 3: June 2008	1VJ7	31.2%	Bacillus anthracis	Cellular processes: Adaptations to atypical conditions	N/A

IDP02827 (show subtarget assignments)	1	cloned	No	FTT1508c	56708546	relA	GTP pyrophosphokinase [Francisella tular...	647	Drug Target	Phase 3: June 2008	1VJ7	20.1%	Francisella tularensis	Cellular processes	Adaptations to atypical conditions

IDP05744 (show subtarget assignments)	1	cloned	No	CD2744	126700359	relA	putative GTP pyrophosphokinase [Clostrid...	735	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1VJ7	26.4%	Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP01729 (show subtarget assignments)	1	cloned	No	FTT0808	56707919	spoT	guanosine-3',5'-bis(diphosphate) 3'-pyro...	707	Conserved; Drug target functions	Phase 3: June 2008	1VJ7	23.6%	Francisella tularensis	Regulatory functionsAmino acid biosynthesis	OtherHistidine family

IDP04269 (show subtarget assignments)	1	cloned	No	CPF_2193	110798612	relA	GTP pyrophosphokinase [Clostridium perfr...	726	conserved gene; putative drug target function;	Phase 4: April 2009	1VJ7	28.1%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP05122 (show subtarget assignments)	1	expressed	No	BA_3551	30258083	amyS	alpha-amylase [Bacillus anthracis str. A...	513	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VJS	68.6%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02227 (show subtarget assignments)	1	cloned	No	FTT1063	56708148	hemF	coproporphyrinogen III oxidase [Francise...	308	Drug Target	Phase 3: June 2008	1VJU	51.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP00139 (show subtarget assignments)	1	crystallized	No	BA_4355	30258855	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1VKN	40.5%	Bacillus anthracis	Unknown function	General

IDP90869 (show subtarget assignments)	8	cloned	No	Cj1250	15792574	purD	phosphoribosylamine--glycine ligase [Cam...	416	Predicted Essential	Community Requests	1VKZ	42.3%	Campylobacter jejuni

IDP02815 (show subtarget assignments)	1	soluble	No	GBAA4880	47530173	argG	argininosuccinate synthase [Bacillus ant...	401	Conserved; Drug target functions	Phase 3: June 2008	1VL2	46.7%	Bacillus anthracis	Amino acid biosynthesis	Glutamate family

IDP02324 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0581	56707709	coaD	phosphopantetheine adenylyltransferase [...	162	Conserved; Drug target functions	Phase 3: June 2008	1VLH	50.6%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pantothenate and coenzyme A

IDP02055 (show subtarget assignments)	1	cloned	No	Cj1327	15792650	neuB2	N-acetylneuraminic acid synthetase [Camp...	334	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...	Phase 3: June 2008	1VLI	36.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02578 (show subtarget assignments)	1	expressed	No	STM0262	16763645	yafS	putative SAM-dependent methyltransferase...	240	Conserved; Drug target functions	Phase 3: June 2008	1VLM	11.7%	Salmonella enterica	Unknown function	General

IDP01830 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0407	56707556	gcvT	glycine cleavage system aminomethyltrans...	358	Drug Target	Phase 3: June 2008	1VLO	47.9%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP01831 (show subtarget assignments)	1	cloned	No	GBAA3985	47529275	ftsY	signal recognition particle-docking prot...	329	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VMA	48.6%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP90987 (show subtarget assignments)	8	crystallized	No	y1125	22125029		hypothetical protein y1125 [Yersinia pes...	297	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests	1VP5	57.2%	Yersinia pestis

IDP02056 (show subtarget assignments)	1	expressed	No	CBU_0934	29541521		ABC transporter, ATP-binding protein [Co...	304	Conserved; Drug target functions	Phase 3: June 2008	1VPL	27.6%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04245 (show subtarget assignments)	1	cloned	No	CPF_1193	110801261		bacitracin ABC transporter, ATP-binding ...	306	conserved gene; putative drug target function;	Phase 4: April 2009	1VPL	27.5%	Clostridium perfringens	Cellular processes	Toxin production and resistance

IDP01660 (show subtarget assignments)	1	expressed	No	CBU_0776	29541372		ABC transporter, ATP-binding protein [Co...	283	Conserved; Drug target functions	Phase 3: June 2008	1VPL	25.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00780 (show subtarget assignments)	1	expressed	No	SACOL0694	57285664		tagH protein, teichoic acid ABC transpor...	264	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	23.9%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01165 (show subtarget assignments)	1	expressed	No	BA_5650	30260099		ABC transporter, ATP-binding protein	305	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01163 (show subtarget assignments)	1	purified	No	BA_5526	30259986		ABC transporter, ATP-binding protein	280	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	30%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01160 (show subtarget assignments)	1	expressed	No	BA_4774	30259261		bacitracin ABC transporter, ATP-binding ...	307	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	25.7%	Bacillus anthracis	Transport and binding proteins	Other

IDP01159 (show subtarget assignments)	1	soluble	No	BA_4745	30259235		ABC transporter, ATP-binding protein	294	Conserved Gene / Pathway	Phase 2: March 2008	1VPL	24.8%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02501 (show subtarget assignments)	1	cloned	No	GBAA1250	47526516	trpD	anthranilate phosphoribosyltransferase [...	341	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VQU	39.6%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP91257 (show subtarget assignments)	8	soluble	No	NT02SA1359	14247140	trpD	anthranilate phosphoribosyltransferase [...	332	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	33.8%	Staphylococcus aureus	Amino acid biosynthesis: Aromatic amino acid family

IDP00322 (show subtarget assignments)	1	expressed	No	Cj0346	15791714	trpD	anthranilate synthase component II	533	Drug Target Function	Phase 2: March 2008	1VQU	20.6%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP91251 (show subtarget assignments)	8	expressed	No	NT01LM1754	16411067	trpD	trpD [Listeria monocytogenes]	339	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	41.2%	Listeria monocytogenes	Amino acid biosynthesis: Aromatic amino acid family

IDP01926 (show subtarget assignments)	1	cloned	No	lmo0931	16802971		hypothetical protein lmo0931 [Listeria m...	331	Known virulence-Intracellular Survival; PMID:17908209	Phase 3: June 2008	1VQZ	44.7%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Lipoate

IDP05247 (show subtarget assignments)	1	cloned	No	lmo2636	16804674	-	hypothetical protein lmo2636 [Listeria m...	360	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VRM	29.4%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04513 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2363	110799064		putative thiamin biosynthesis lipoprotei...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1VRM	29.2%	Clostridium perfringens	Biosynthesis of cofactors, prosthetic groups, and carriers	Thiamine

IDP05325 (show subtarget assignments)	1	purified	No	CD2483	126700100		hypothetical protein CD2483 [Clostridium...	342	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VRM	29.2%	Clostridium difficile	Cell envelope: Other

IDP90505 (show subtarget assignments)	8	soluble	No	YPO0231	16120569	rpsM	30S ribosomal protein S13	118	Predicted Essential	Community Requests	1VS5	85.6%	Yersinia pestis

IDP04593 (show subtarget assignments)	1	cloned	No	BAS0144	49183178		30S ribosomal protein S9 [Bacillus anthr...	130	Proposed to be essential proteins	Phase 4: April 2009	1VS5	55.4%	Bacillus anthracis

IDP90550 (show subtarget assignments)	8	purified	No	Cj1594	15792899	rpsD	30S ribosomal protein S4 [Campylobacter ...	208	Predicted Essential	Community Requests	1VS5	50.7%	Campylobacter jejuni

IDP90576 (show subtarget assignments)	8	soluble	No	VC0679	15640698	rpsT	30S ribosomal protein S20 [Vibrio choler...	86	Predicted Essential	Community Requests	1VS5	70.9%	Vibrio cholerae

IDP04590 (show subtarget assignments)	1	expressed	No	BAS0136	49183170		30S ribosomal protein S11 [Bacillus anth...	129	Proposed to be essential proteins	Phase 4: April 2009	1VS5	65.9%	Bacillus anthracis

IDP04585 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0116	49183150		30S ribosomal protein S3 [Bacillus anthr...	219	Proposed to be essential proteins	Phase 4: April 2009	1VS5	54.3%	Bacillus anthracis

IDP90619 (show subtarget assignments)	8	soluble	No	Cj1701c	15793004	rpsC	30S ribosomal protein S3 [Campylobacter ...	233	Predicted Essential	Community Requests	1VS5	56.7%	Campylobacter jejuni

IDP04034 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0128	49183162		50S ribosomal protein L30 [Bacillus anth...	60	Proposed to be essential proteins	Phase 4: April 2009	1VS6	53.3%	Bacillus anthracis

IDP04570 (show subtarget assignments)	1	soluble	No	FTT0153	56707323	rplS	50S ribosomal protein L19 [Francisella t...	115	drug target; conserved gene;	Phase 4: April 2009	1VS6	58.3%	Francisella tularensis	Protein synthesis	Ribosomal proteins: synthesis and modification

IDP04074 (show subtarget assignments)	1	cloned	No	BAS4469	49187464		50S ribosomal protein L20 [Bacillus anth...	118	Proposed to be essential proteins	Phase 4: April 2009	1VS6	55.1%	Bacillus anthracis

IDP91418 (show subtarget assignments)	8	expressed	No	VV1_0671	27364128	rplU	50S ribosomal protein L21 [Vibrio vulnif...	103	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1VS6	78.6%	Vibrio vulnificus

IDP04135 (show subtarget assignments)	1	cloned	No	BAS4470	49187465		50S ribosomal protein L35 [Bacillus anth...	66	Proposed to be essential proteins	Phase 4: April 2009	1VS6	48.5%	Bacillus anthracis

IDP04311 (show subtarget assignments)	1	purified	No	BAS4340	49187335		50S ribosomal protein L27 [Bacillus anth...	96	Proposed to be essential proteins	Phase 4: April 2009	1VSA	55.2%	Bacillus anthracis

IDP04071 (show subtarget assignments)	1	cloned	No	BAS0129	49183163		50S ribosomal protein L15 [Bacillus anth...	146	Proposed to be essential proteins	Phase 4: April 2009	1VSA	51.4%	Bacillus anthracis

IDP04707 (show subtarget assignments)	1	cloned	No	BAS0113	49183147		50S ribosomal protein L2 [Bacillus anthr...	276	Proposed to be essential proteins	Phase 4: April 2009	1VSA	65%	Bacillus anthracis

IDP04617 (show subtarget assignments)	1	expressed	No	BAS4342	49187337		50S ribosomal protein L21 [Bacillus anth...	102	Proposed to be essential proteins	Phase 4: April 2009	1VSA	54.9%	Bacillus anthracis

IDP04586 (show subtarget assignments)	1	cloned	No	BAS0117	49183151		50S ribosomal protein L16 [Bacillus anth...	144	Proposed to be essential proteins	Phase 4: April 2009	1VSA	60.4%	Bacillus anthracis

IDP91244
(show subtarget assignments)

8

soluble

No

HP0663

0

365

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1UM0

100%

Helicobacter pylori

Amino acid biosynthesis: Aromatic amino acid family

IDP04231
(show subtarget assignments)

1

purified

No

CPF_0690

110800421

aroC

chorismate synthase [Clostridium perfrin...

357

conserved gene; putative drug target function;

Phase 4: April 2009

1UM0

39.8%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP00338
(show subtarget assignments)

1

cloned

No

FTT0876c

56707980

aroC

chorismate synthase

352

Drug Target Function

Phase 2: March 2008

1UM0

47.4%

Francisella tularensis

Amino acid biosynthesis

Aromatic amino acid family

IDP02745
(show subtarget assignments)

1

cloned

No

GBAA4384

47529679

bfmbAa

3-methyl-2-oxobutanoate dehydrogenase, a...

333

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

41.7%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02743
(show subtarget assignments)

1

cloned

No

GBAA4383

47529678

bfmbAb

3-methyl-2-oxobutanoate dehydrogenase, b...

327

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1UM9

52.9%

Bacillus anthracis

Energy metabolism

Amino acids and amines

IDP02125
(show subtarget assignments)

1

cloned

No

STM4453

16767699

treC

trehalose-6-phosphate hydrolase [Salmone...

550

Conserved; Drug target functions

Phase 3: June 2008

1UOK

44.7%

Salmonella enterica

Energy metabolism

Other

IDP05215
(show subtarget assignments)

1

cloned

No

CD3091

126700708

treA

trehalose-6-phosphate hydrolase [Clostri...

555

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1UOK

50.2%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05181
(show subtarget assignments)

1

soluble

No

BA_4729

30259221

bacterial extracellular solute-binding p...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1UQW

30.3%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP04377
(show subtarget assignments)

1

soluble

No

CPF_2652

110798678

putative maltose/maltodextrin ABC transp...

408

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1URG

38.7%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01008
(show subtarget assignments)

1

soluble

No

STM2533

16765853

sseA

3-mercaptopyruvate sulfurtransferase

280

Conserved Gene / Pathway

Phase 2: March 2008

1URH

79.6%

Salmonella enterica

Cellular processes

Detoxification

IDP00258
(show subtarget assignments)

1

in_crystallization_trials

No

MMLVgp1

22550316

Montana myotis leukoencephalitis Envelop...

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.6%

Montana myotis

IDP00256
(show subtarget assignments)

1

expressed

No

RBVgp1

21397175

Rio Bravo bat virus Envelope protein

395

Entry and Cell-Cell Fusion: Contains receptor binding sites and fusogenic domain...

Phase 1: October 2007

1URZ

43.2%

Rio Bravo

IDP00475
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3808

16123942

livK

branched-chain amino acid-binding protei...

371

Virulence Associated Factor

Phase 2: March 2008

1USG

71.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00473
(show subtarget assignments)

1

cloned

No

YPO0107

16120454

ftsN

cell division protein FtsN

281

Conserved Gene / Pathway

Phase 2: March 2008

1UTA

15.3%

Yersinia pestis

Cellular processes

Cell division

IDP01686
(show subtarget assignments)

1

cloned

No

Cj0804

15792142

pyrD

dihydroorotate dehydrogenase 2 [Campylob...

352

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1UUM

40.3%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP04154
(show subtarget assignments)

1

cloned

No

YPO4017

218931008

hutU

urocanate hydratase [Yersinia pestis CO9...

563

conserved gene; putative drug target function;

Phase 4: April 2009

1UWL

86.3%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP00686
(show subtarget assignments)

1

purified

No

SACOL2029

57284899

cscA

sucrose-6-phosphate hydrolase

494

Drug Target Function

Phase 2: March 2008

1UYP

29.8%

Staphylococcus aureus

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP02039
(show subtarget assignments)

1

expressed

No

YPO1198

16121491

putative ABC transport ATP-binding subun...

312

Conserved; CD; Drug target functions

Phase 3: June 2008

1V43

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00988
(show subtarget assignments)

1

expressed

No

STM2163

16765493

yehX

putative ABC-type proline/glycine betain...

315

Conserved Gene / Pathway

Phase 2: March 2008

1V43

32.4%

Salmonella enterica

Transport and binding proteins

Other

IDP01902
(show subtarget assignments)

1

soluble

No

STM0878

16764240

potG

putrescine transporter ATP-binding subun...

377

Conserved; Drug target functions

Phase 3: June 2008

1V43

38.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01341
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0687

15601444

fbpC

ferric transporter ATP-binding subunit

351

Conserved Gene / Pathway

Phase 2: March 2008

1V43

38.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02608
(show subtarget assignments)

1

expressed

No

CBU_0178

29540794

ABC transporter, ATP-binding protein [Co...

252

Conserved; Drug target functions

Phase 3: June 2008

1V43

43.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01922
(show subtarget assignments)

1

expressed

No

GBAA1441

47526716

sat

sulfate adenylyltransferase [Bacillus an...

378

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1V47

39.4%

Bacillus anthracis

Central intermediary metabolism

Sulfur metabolism

IDP01920
(show subtarget assignments)

1

expressed

No

CBU_1156

29541728

trpA

tryptophan synthase, alpha subunit [Coxi...

267

Conserved; Drug target functions

Phase 3: June 2008

1V7Y

35.6%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP00464
(show subtarget assignments)

1

purified

No

YPO2522

16122741

hypothetical protein YPO2522

319

Drug Target Function

Phase 2: March 2008

1V8G

24.5%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90720
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0348

15791716

trpB

tryptophan synthase subunit beta [Campyl...

392

Predicted Essential

Community Requests

1V8Z

51.5%

Campylobacter jejuni

IDP00302
(show subtarget assignments)

1

expressed

No

CBU_1155

29654460

trpBF

N-(5'phosphoribosyl)anthranilate isomera...

600

Drug Target Function

Phase 2: March 2008

1V8Z

38%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP90670
(show subtarget assignments)

8

soluble

No

Cj1202

15792526

metF

5,10-methylenetetrahydrofolate reductase...

282

Predicted Essential

Community Requests

1V93

34%

Campylobacter jejuni

IDP04648
(show subtarget assignments)

1

selected

No

FTT1245

56708307

rluD

ribosomal large subunit pseudouridine sy...

332

drug target; conserved gene;

Phase 4: April 2009

1V9F

43.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP90958
(show subtarget assignments)

8

cloned

No

UTI89_C1702

122423767

Hypothetical protein

807

C-di-GMP is a universal bacterial second messenger regulating cell-surface assoc...

Community Requests

1V9Y

18%

Escherichia coli

IDP00778
(show subtarget assignments)

1

cloned

No

SACOL0668

57284264

hydrolase, alpha/beta hydrolase fold fam...

266

Drug Target Function

Phase 2: March 2008

1VA4

26.1%

Staphylococcus aureus

Unknown function

Enzymes of unknown specificity

IDP00901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0004

16763394

thrC

threonine synthase

428

Conserved Gene / Pathway

Phase 2: March 2008

1VB3

93.5%

Salmonella enterica

Amino acid biosynthesis

Aspartate family

IDP02201
(show subtarget assignments)

1

soluble

No

YPO0461

16120790

thrC

threonine synthase [Yersinia pestis CO92...

429

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1VB3

82.3%

Yersinia pestis

Amino acid biosynthesis

Aspartate family

IDP02131
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1419c

15792737

methyltransferase [Campylobacter jejuni ...

253

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

1VE3

18.2%

Campylobacter jejuni

Cell envelope

Other

IDP91265
(show subtarget assignments)

8

cloned

No

NT05BA1551

49178367

2-heptaprenyl-1,4-naphthoquinone methylt...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VE3

24.9%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP02142
(show subtarget assignments)

1

cloned

No

CBU_0754

29541354

efflux transporter, RND family, MFP subu...

348

Conserved; Drug target functions

Phase 3: June 2008

1VF7

24.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP04483
(show subtarget assignments)

1

expressed

No

YPO3361

115348990

b2747

4-diphosphocytidyl-2C-methyl-D-erythrito...

241

conserved gene; putative drug target function;

Phase 4: April 2009

1VGT

63.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90706
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1048c

15792375

dapE

succinyl-diaminopimelate desuccinylase [...

365

Predicted Essential

Community Requests

1VGY

39%

Campylobacter jejuni

IDP00947
(show subtarget assignments)

1

purified

No

STM0988

16764348

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

248

Essential Gene

Phase 2: March 2008

1VH1

94%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91094
(show subtarget assignments)

8

cloned

No

APL_0085

126096365

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

250

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

1VH3

70.6%

Actinobacillus pleuropneumoniae

IDP92138
(show subtarget assignments)

8

selected

No

TGME49_073450

237833297

sufB/sufD domain-containing protein [Tox...

1267

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1VH4

3.3%

Toxoplasma gondii

IDP91006
(show subtarget assignments)

8

soluble

No

y1937

22125829

cysteine desulfurase activator complex s...

441

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

1VH4

56%

Yersinia pestis

IDP05120
(show subtarget assignments)

1

in_crystallization_trials

No

CD0236

126697807

fliS2

flagellar protein [Clostridium difficile...

116

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VH6

26.7%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05188
(show subtarget assignments)

1

purified

No

CD0235

126697806

fliS1

flagellar protein FliS [Clostridium diff...

131

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VH6

29.8%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02254
(show subtarget assignments)

1

cloned

No

FTT0766

56707880

deoD

purine nucleoside phosphorylase [Francis...

240

Drug Target

Phase 3: June 2008

1VHJ

43.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02534
(show subtarget assignments)

1

cloned

No

GBAA4614

47529912

Holliday junction resolvase-like protein...

137

Conserved;

Phase 3: June 2008

1VHX

70.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP04608
(show subtarget assignments)

1

soluble

No

BAS3704

49186703

putative glycerol-3-phosphate acyltransf...

330

Proposed to be essential proteins

Phase 4: April 2009

1VI1

66.4%

Bacillus anthracis

IDP90814
(show subtarget assignments)

8

soluble

No

Cj0329c

15791697

plsX

putative glycerol-3-phosphate acyltransf...

328

Predicted Essential

Community Requests

1VI1

38.4%

Campylobacter jejuni

IDP05324
(show subtarget assignments)

1

cloned

No

CD3431

126701054

putative cobalamin biosynthesis kinase [...

295

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VIS

24.7%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00195
(show subtarget assignments)

1

cloned

No

YPO1009

16121311

-

probable peptidase

410

Similar to Essential SALTY

Phase 1: October 2007

1VIX

38%

Yersinia pestis

Hypothetical proteins

Conserved

IDP01483
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0180

15600950

peptidase T

410

Drug Target Function

Phase 2: March 2008

1VIX

57.6%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02040
(show subtarget assignments)

1

expressed

No

GBAA4637

47529935

relA

GTP pyrophosphokinase [Bacillus anthraci...

727

CONSERVED. Additional information: It is responsible for a down-regulation of RN...

Phase 3: June 2008

1VJ7

31.2%

Bacillus anthracis

Cellular processes: Adaptations to atypical conditions

N/A

IDP02827
(show subtarget assignments)

1

cloned

No

FTT1508c

56708546

relA

GTP pyrophosphokinase [Francisella tular...

647

Drug Target

Phase 3: June 2008

1VJ7

20.1%

Francisella tularensis

Cellular processes

Adaptations to atypical conditions

IDP05744
(show subtarget assignments)

1

cloned

No

CD2744

126700359

relA

putative GTP pyrophosphokinase [Clostrid...

735

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1VJ7

26.4%

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP01729
(show subtarget assignments)

1

cloned

No

FTT0808

56707919

spoT

guanosine-3',5'-bis(diphosphate) 3'-pyro...

707

Conserved; Drug target functions

Phase 3: June 2008

1VJ7

23.6%

Francisella tularensis

Regulatory functionsAmino acid biosynthesis

OtherHistidine family

IDP04269
(show subtarget assignments)

1

cloned

No

CPF_2193

110798612

relA

GTP pyrophosphokinase [Clostridium perfr...

726

conserved gene; putative drug target function;

Phase 4: April 2009

1VJ7

28.1%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP05122
(show subtarget assignments)

1

expressed

No

BA_3551

30258083

amyS

alpha-amylase [Bacillus anthracis str. A...

513

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VJS

68.6%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP02227
(show subtarget assignments)

1

cloned

No

FTT1063

56708148

hemF

coproporphyrinogen III oxidase [Francise...

308

Drug Target

Phase 3: June 2008

1VJU

51.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP00139
(show subtarget assignments)

1

crystallized

No

BA_4355

30258855

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1VKN

40.5%

Bacillus anthracis

Unknown function

General

IDP90869
(show subtarget assignments)

8

cloned

No

Cj1250

15792574

purD

phosphoribosylamine--glycine ligase [Cam...

416

Predicted Essential

Community Requests

1VKZ

42.3%

Campylobacter jejuni

IDP02815
(show subtarget assignments)

1

soluble

No

GBAA4880

47530173

argG

argininosuccinate synthase [Bacillus ant...

401

Conserved; Drug target functions

Phase 3: June 2008

1VL2

46.7%

Bacillus anthracis

Amino acid biosynthesis

Glutamate family

IDP02324
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0581

56707709

coaD

phosphopantetheine adenylyltransferase [...

162

Conserved; Drug target functions

Phase 3: June 2008

1VLH

50.6%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pantothenate and coenzyme A

IDP02055
(show subtarget assignments)

1

cloned

No

Cj1327

15792650

neuB2

N-acetylneuraminic acid synthetase [Camp...

334

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...

Phase 3: June 2008

1VLI

36.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02578
(show subtarget assignments)

1

expressed

No

STM0262

16763645

yafS

putative SAM-dependent methyltransferase...

240

Conserved; Drug target functions

Phase 3: June 2008

1VLM

11.7%

Salmonella enterica

Unknown function

General

IDP01830
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0407

56707556

gcvT

glycine cleavage system aminomethyltrans...

358

Drug Target

Phase 3: June 2008

1VLO

47.9%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP01831
(show subtarget assignments)

1

cloned

No

GBAA3985

47529275

ftsY

signal recognition particle-docking prot...

329

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VMA

48.6%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP90987
(show subtarget assignments)

8

crystallized

No

y1125

22125029

hypothetical protein y1125 [Yersinia pes...

297

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

1VP5

57.2%

Yersinia pestis

IDP02056
(show subtarget assignments)

1

expressed

No

CBU_0934

29541521

ABC transporter, ATP-binding protein [Co...

304

Conserved; Drug target functions

Phase 3: June 2008

1VPL

27.6%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04245
(show subtarget assignments)

1

cloned

No

CPF_1193

110801261

bacitracin ABC transporter, ATP-binding ...

306

conserved gene; putative drug target function;

Phase 4: April 2009

1VPL

27.5%

Clostridium perfringens

Cellular processes

Toxin production and resistance

IDP01660
(show subtarget assignments)

1

expressed

No

CBU_0776

29541372

ABC transporter, ATP-binding protein [Co...

283

Conserved; Drug target functions

Phase 3: June 2008

1VPL

25.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00780
(show subtarget assignments)

1

expressed

No

SACOL0694

57285664

tagH protein, teichoic acid ABC transpor...

264

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

23.9%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01165
(show subtarget assignments)

1

expressed

No

BA_5650

30260099

ABC transporter, ATP-binding protein

305

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01163
(show subtarget assignments)

1

purified

No

BA_5526

30259986

ABC transporter, ATP-binding protein

280

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

30%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01160
(show subtarget assignments)

1

expressed

No

BA_4774

30259261

bacitracin ABC transporter, ATP-binding ...

307

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

25.7%

Bacillus anthracis

Transport and binding proteins

Other

IDP01159
(show subtarget assignments)

1

soluble

No

BA_4745

30259235

ABC transporter, ATP-binding protein

294

Conserved Gene / Pathway

Phase 2: March 2008

1VPL

24.8%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02501
(show subtarget assignments)

1

cloned

No

GBAA1250

47526516

trpD

anthranilate phosphoribosyltransferase [...

341

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VQU

39.6%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP91257
(show subtarget assignments)

8

soluble

No

NT02SA1359

14247140

trpD

anthranilate phosphoribosyltransferase [...

332

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

33.8%

Staphylococcus aureus

Amino acid biosynthesis: Aromatic amino acid family

IDP00322
(show subtarget assignments)

1

expressed

No

Cj0346

15791714

trpD

anthranilate synthase component II

533

Drug Target Function

Phase 2: March 2008

1VQU

20.6%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP91251
(show subtarget assignments)

8

expressed

No

NT01LM1754

16411067

trpD

trpD [Listeria monocytogenes]

339

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

41.2%

Listeria monocytogenes

Amino acid biosynthesis: Aromatic amino acid family

IDP01926
(show subtarget assignments)

1

cloned

No

lmo0931

16802971

hypothetical protein lmo0931 [Listeria m...

331

Known virulence-Intracellular Survival; PMID:17908209

Phase 3: June 2008

1VQZ

44.7%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Lipoate

IDP05247
(show subtarget assignments)

1

cloned

No

lmo2636

16804674

-

hypothetical protein lmo2636 [Listeria m...

360

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VRM

29.4%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04513
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2363

110799064

putative thiamin biosynthesis lipoprotei...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1VRM

29.2%

Clostridium perfringens

Biosynthesis of cofactors, prosthetic groups, and carriers

Thiamine

IDP05325
(show subtarget assignments)

1

purified

No

CD2483

126700100

hypothetical protein CD2483 [Clostridium...

342

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VRM

29.2%

Clostridium difficile

Cell envelope: Other

IDP90505
(show subtarget assignments)

8

soluble

No

YPO0231

16120569

rpsM

30S ribosomal protein S13

118

Predicted Essential

Community Requests

1VS5

85.6%

Yersinia pestis

IDP04593
(show subtarget assignments)

1

cloned

No

BAS0144

49183178

30S ribosomal protein S9 [Bacillus anthr...

130

Proposed to be essential proteins

Phase 4: April 2009

1VS5

55.4%

Bacillus anthracis

IDP90550
(show subtarget assignments)

8

purified

No

Cj1594

15792899

rpsD

30S ribosomal protein S4 [Campylobacter ...

208

Predicted Essential

Community Requests

1VS5

50.7%

Campylobacter jejuni

IDP90576
(show subtarget assignments)

8

soluble

No

VC0679

15640698

rpsT

30S ribosomal protein S20 [Vibrio choler...

86

Predicted Essential

Community Requests

1VS5

70.9%

Vibrio cholerae

IDP04590
(show subtarget assignments)

1

expressed

No

BAS0136

49183170

30S ribosomal protein S11 [Bacillus anth...

129

Proposed to be essential proteins

Phase 4: April 2009

1VS5

65.9%

Bacillus anthracis

IDP04585
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0116

49183150

30S ribosomal protein S3 [Bacillus anthr...

219

Proposed to be essential proteins

Phase 4: April 2009

1VS5

54.3%

Bacillus anthracis

IDP90619
(show subtarget assignments)

8

soluble

No

Cj1701c

15793004

rpsC

30S ribosomal protein S3 [Campylobacter ...

233

Predicted Essential

Community Requests

1VS5

56.7%

Campylobacter jejuni

IDP04034
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0128

49183162

50S ribosomal protein L30 [Bacillus anth...

60

Proposed to be essential proteins

Phase 4: April 2009

1VS6

53.3%

Bacillus anthracis

IDP04570
(show subtarget assignments)

1

soluble

No

FTT0153

56707323

rplS

50S ribosomal protein L19 [Francisella t...

115

drug target; conserved gene;

Phase 4: April 2009

1VS6

58.3%

Francisella tularensis

Protein synthesis

Ribosomal proteins: synthesis and modification

IDP04074
(show subtarget assignments)

1

cloned

No

BAS4469

49187464

50S ribosomal protein L20 [Bacillus anth...

118

Proposed to be essential proteins

Phase 4: April 2009

1VS6

55.1%

Bacillus anthracis

IDP91418
(show subtarget assignments)

8

expressed

No

VV1_0671

27364128

rplU

50S ribosomal protein L21 [Vibrio vulnif...

103

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1VS6

78.6%

Vibrio vulnificus

IDP04135
(show subtarget assignments)

1

cloned

No

BAS4470

49187465

50S ribosomal protein L35 [Bacillus anth...

66

Proposed to be essential proteins

Phase 4: April 2009

1VS6

48.5%

Bacillus anthracis

IDP04311
(show subtarget assignments)

1

purified

No

BAS4340

49187335

50S ribosomal protein L27 [Bacillus anth...

96

Proposed to be essential proteins

Phase 4: April 2009

1VSA

55.2%

Bacillus anthracis

IDP04071
(show subtarget assignments)

1

cloned

No

BAS0129

49183163

50S ribosomal protein L15 [Bacillus anth...

146

Proposed to be essential proteins

Phase 4: April 2009

1VSA

51.4%

Bacillus anthracis

IDP04707
(show subtarget assignments)

1

cloned

No

BAS0113

49183147

50S ribosomal protein L2 [Bacillus anthr...

276

Proposed to be essential proteins

Phase 4: April 2009

1VSA

65%

Bacillus anthracis

IDP04617
(show subtarget assignments)

1

expressed

No

BAS4342

49187337

50S ribosomal protein L21 [Bacillus anth...

102

Proposed to be essential proteins

Phase 4: April 2009

1VSA

54.9%

Bacillus anthracis

IDP04586
(show subtarget assignments)

1

cloned

No

BAS0117

49183151

50S ribosomal protein L16 [Bacillus anth...

144

Proposed to be essential proteins

Phase 4: April 2009

1VSA

60.4%

Bacillus anthracis