Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP90946 (show subtarget assignments)	8	cloned	No	BP1878	33592926	bvgA	virulence factors transcription regulato...	209	BvgA is the transcriptional activator for all known virulence genes in the human...	Community Requests	3C3W	31.6%	Bordetella pertussis

IDP02719 (show subtarget assignments)	1	cloned	No	lmo0262	16802308	inlG	internalin G [Listeria monocytogenes EGD...	490	Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815	Phase 3: June 2008	1M9S	31.6%	Listeria monocytogenes	Cellular processes	Pathogenesis

IDP01654 (show subtarget assignments)	1	expressed	No	STM1259	16764611		putative ABC-type transport system ATPas...	196	Conserved; Drug target functions	Phase 3: June 2008	1Z47	31.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP90167 (show subtarget assignments)	8	purified	No	CD1838	123066836		Shikimate kinase	177	Potential drug target. Shikimate pathway enzyme	Community Requests	2PT5	31.6%	Clostridium difficile

IDP91080 (show subtarget assignments)	8	cloned	No	Cj0803	6968244	msbA	lipid export ABC transport protein	580	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	31.6%	Campylobacter jejuni

IDP00709 (show subtarget assignments)	1	purified	No	SACOL0798	57285759		iron compound ABC transporter, ATP-bindi...	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	31.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222 (show subtarget assignments)	1	purified	No	BA_4049	33301352		UDP-N-acetylglucosamine--N-acetylmuramyl...	364	Drug Target Function	Phase 2: March 2008	1F0K	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00634 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1722	57284733	tig	trigger factor	433	Drug Target Function	Phase 2: March 2008	1W26	31.6%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP05255 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0663	57650073	argS	arginyl-tRNA synthetase [Staphylococcus ...	553	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05228 (show subtarget assignments)	1	soluble	No	lmo0971	16803011	dltD	DltD protein for D-alanine esterificatio...	380	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3BMA	31.6%	Listeria monocytogenes	Cell envelope: Other

IDP02469 (show subtarget assignments)	1	cloned	No	FTT0573	56707702	alr	alanine racemase [Francisella tularensis...	365	Conserved; Drug target functions	Phase 3: June 2008	4A3Q	31.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90529 (show subtarget assignments)	8	soluble	No	YPO1127	16121427	nicA	quinolinate synthetase	353	Predicted Essential	Community Requests	2QS0	31.7%	Yersinia pestis

IDP00732 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2473	57286467		peptide ABC transporter, ATP-binding pro...	271	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	31.7%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP00724 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1822	57286255	arsR	arsenical resistance operon repressor	104	Conserved Gene / Pathway	Phase 2: March 2008	1R1T	31.7%	Staphylococcus aureus	Cellular processes	Detoxification

IDP00155 (show subtarget assignments)	1	in_crystallization_trials	No	VC0405	15640432	mshE	MSHA biogenesis protein MshE	575	Virulence	Phase 1: October 2007	1P9R	31.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP05766 (show subtarget assignments)	1	expressed	No	S0723	30040469		putative helicase [Shigella flexneri 2a ...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2R6A	31.7%	Shigella flexneri	DNA metabolism: DNA replication, recombination, and repair

IDP00518 (show subtarget assignments)	1	cloned	No	YPO1566	16121836		putative hydrolase	280	Virulence Associated Factor	Phase 2: March 2008	3QDF	31.8%	Yersinia pestis	Cellular processes	Toxin production and resistance

IDP04136 (show subtarget assignments)	1	diffraction	No	GBAA4258	47529551		5-methylthio-3-oxo-1-penten-1,2-diol dio...	170	putative drug target function;	Phase 4: April 2009	1ZRR	31.8%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP05453 (show subtarget assignments)	1	in_crystallization_trials	No	BAS5213	49188199	-	arginyl-tRNA synthetase [Bacillus anthra...	556	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.8%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP02376 (show subtarget assignments)	1	cloned	No	FTT0451	56707593	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	416	Conserved; Drug target functions	Phase 3: June 2008	1E0D	31.8%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00721 (show subtarget assignments)	1	expressed	No	SACOL1613	57286135		ABC transporter, ATP-binding protein	261	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	31.8%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP05504 (show subtarget assignments)	1	purified	No	CD0869	126698446	modA	putative molybdenum ABC transporter,subs...	270	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1AMF	31.9%	Clostridium difficile	Transport and binding proteins: Anions

IDP91089 (show subtarget assignments)	8	soluble	No	NT06FT0892	0			323	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	31.9%	Francisella tularensis	Energy metabolism: Sugars

IDP04262 (show subtarget assignments)	1	cloned	No	CPF_2067	110799430	spo0A	Spo0A protein [Clostridium perfringens A...	276	conserved gene; putative drug target function;	Phase 4: April 2009	1LQ1	31.9%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05085 (show subtarget assignments)	1	soluble	No	Z4863	12518151		putative 3-oxoacyl-[ACP] synthase [Esche...	389	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3KZU	31.9%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP90839 (show subtarget assignments)	8	purified	No	Cj0641	15792001		ATP-NAD kinase, putative [Campylobacter ...	286	Predicted Essential	Community Requests	2AN1	31.9%	Campylobacter jejuni

IDP04681 (show subtarget assignments)	1	soluble	No	GBAA3131	47528422	adhB	alcohol dehydrogenase, zinc-containing [...	377	virulence factor; putative drug target function;	Phase 4: April 2009	1KOL	31.9%	Bacillus anthracis	Energy metabolism	Fermentation

IDP91185 (show subtarget assignments)	8	cloned	No	AAC46367	2352978			477	virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...	Community Requests	1NY5	31.9%	Vibrio cholerae

IDP01879 (show subtarget assignments)	1	cloned	No	FTT1804c	56708790	rng	ribonuclease G [Francisella tularensis s...	498	Conserved; Drug target functions	Phase 3: June 2008	2BX2	31.9%	Francisella tularensis	Cellular processesTranscription	Cell divisionRNA processing

IDP00942 (show subtarget assignments)	1	in_crystallization_trials	No	STM0857	16764219		putative acyl-CoA dehydrogenase	387	Essential Gene	Phase 2: March 2008	3MPI	32%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP01953 (show subtarget assignments)	1	soluble	No	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP05722 (show subtarget assignments)	1	purified	No	BA_2954	30257545	tyrA	prephenate dehydrogenase [Bacillus anthr...	378	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DZB	32%	Bacillus anthracis	Amino acid biosynthesis: Aromatic amino acid family

IDP00704 (show subtarget assignments)	1	expressed	No	SACOL0264	57286724		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	32%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP05765 (show subtarget assignments)	1	soluble	No	lmo2812	16804849	-	hypothetical protein lmo2812 [Listeria m...	272	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IT9	32%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00330 (show subtarget assignments)	1	purified	No	Cj0345	15791713	trpE	putative anthranilate synthase component...	416	Drug Target Function	Phase 2: March 2008	1QDL	32%	Campylobacter jejuni	Amino acid biosynthesis	Aromatic amino acid family

IDP00614 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2109	57286325		modification methylase, HemK family	278	Drug Target Function	Phase 2: March 2008	1T43	32%	Staphylococcus aureus	Unknown function	General

IDP90352 (show subtarget assignments)	8	expressed	No	CT262	15604983		hypothetical protein CT262 [Chlamydia tr...	256	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2CZL	32%	Chlamydia trachomatis

IDP91279 (show subtarget assignments)	8	soluble	No	NT05BA4913	49181643		DNA-binding response regulator [Bacillus...	231	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2OQR	32%	Bacillus anthracis

IDP91070 (show subtarget assignments)	8	cloned	No	RP205	15604078		multidrug resistance transporter ATM1 [R...	609	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	32%	Rickettsia prowazekii

IDP91273 (show subtarget assignments)	8	soluble	No	NT05BA4146	49180892		conserved hypothetical protein TIGR00281...	190	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	2Z99	32.1%	Bacillus anthracis

IDP00119 (show subtarget assignments)	1	purified	No	NT01ST0753	16763999	citE	citrate lyase beta chain	302	Essential	Phase 1: October 2007	1SGJ	32.1%	Salmonella enterica	Energy metabolism	Fermentation

IDP02406 (show subtarget assignments)	1	crystallized	No	GBAA2768	47528059		thioredoxin reductase, putative [Bacillu...	301	Conserved; Essential; Drug target functions	Phase 3: June 2008	3FBS	32.1%	Bacillus anthracis	Energy metabolism	Electron transport

IDP02011 (show subtarget assignments)	1	cloned	No	STM2340	16765667		putative transketolase [Salmonella typhi...	317	Conserved; Drug target functions	Phase 3: June 2008	3MOS	32.1%	Salmonella enterica	Energy metabolism	Pentose phosphate pathway

IDP91989 (show subtarget assignments)	8	purified	No	SpneCM_010100010148	298255940		serine protease [Streptococcus pneumonia...	393	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1Y8T	32.1%	Streptococcus pneumoniae

IDP90197 (show subtarget assignments)	8	soluble	No	AAM13645.1	20153184	CPXV206 CDS	CPXV206 protein	285	serine-threonine kinase	Community Requests	2KTY	32.1%	Cowpox virus	Unknown function	0

IDP02168 (show subtarget assignments)	1	expressed	No	CBU_1289	29541857	dnaJ	chaperone protein dnaJ [Coxiella burneti...	374	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	32.1%	Coxiella burnetii	Protein fate	Protein folding and stabilization

IDP90654 (show subtarget assignments)	8	expressed	No	YPO0474	16120803	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Predicted Essential	Community Requests	1MRZ	32.1%	Yersinia pestis

IDP91074 (show subtarget assignments)	8	cloned	No	MSMEG_5659	118469658		ABC transporter, ATP-binding protein [My...	610	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	32.1%	Mycobacterium smegmatis

IDP05497 (show subtarget assignments)	1	cloned	No	CD0241	126697812		phosphoserine phosphatase [Clostridium d...	205	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F5S	32.1%	Clostridium difficile	Amino acid biosynthesis: Serine family

IDP04235 (show subtarget assignments)	1	cloned	No	CPF_0823	110800089		polysaccharide deacetylase family protei...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W3Z	32.1%	Clostridium perfringens	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP00897 (show subtarget assignments)	1	expressed	No	STM0771	16764135		putative ABC-type cobalamin/Fe3+-siderop...	258	Conserved Gene / Pathway	Phase 2: March 2008	2ONK	32.2%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP01885 (show subtarget assignments)	1	cloned	No	GBAA5639	47530965		D-alanyl-D-alanine carboxypeptidase, put...	423	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00728 (show subtarget assignments)	1	cloned	No	SACOL2210	57284991		ABC transporter, ATP-binding protein	286	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	32.2%	Staphylococcus aureus	Transport and binding proteins	Unknown substrate

IDP91072 (show subtarget assignments)	8	cloned	No	YPO2588	16122801	-	putative ABC transport protein	631	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	2HYD	32.2%	Yersinia pestis

IDP05100 (show subtarget assignments)	1	soluble	No	CD0876	126698453		ABC transporter, substrate-binding lipop...	345	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3LFT	32.2%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP02247 (show subtarget assignments)	1	expressed	No	FTT0665c	56707786		aldolase/adducin class II family protein...	201	Drug Target	Phase 3: June 2008	3OCR	32.3%	Francisella tularensis	Unknown function	General

IDP00058 (show subtarget assignments)	1	soluble	No	BA_3903	30258417		bacteriocin ABC transporter, ATP-binding...	234	Virulence	Phase 1: October 2007	1OXS	32.3%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP92112 (show subtarget assignments)	8	selected	No	TGME49_057730	237831419		methionine aminopeptidase, putative [Tox...	387	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2B3H	32.3%	Toxoplasma gondii

IDP04156 (show subtarget assignments)	1	expressed	No	VC0681	9655120		riboflavin kinase/FMN adenylyltransferas...	322	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1MRZ	32.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP05205 (show subtarget assignments)	1	cloned	No	CD1770	126699379	ogt2	methylated-DNA--protein-cysteine methylt...	164	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2G7H	32.3%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP02523 (show subtarget assignments)	1	cloned	No	GBAA4297	47529591	dacF	D-alanyl-D-alanine carboxypeptidase [Bac...	396	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IT9	32.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02228 (show subtarget assignments)	1	cloned	No	FTT1240c	56708302		hypothetical protein FTT1240c [Francisel...	182	Drug Target	Phase 3: June 2008	2P0T	32.4%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP00988 (show subtarget assignments)	1	expressed	No	STM2163	16765493	yehX	putative ABC-type proline/glycine betain...	315	Conserved Gene / Pathway	Phase 2: March 2008	1V43	32.4%	Salmonella enterica	Transport and binding proteins	Other

IDP00209 (show subtarget assignments)	1	soluble	No	YPO2062	16122301	-	putative M23/M37 peptidase-family protei...	417	Virulence	Phase 1: October 2007	2GU1	32.4%	Yersinia pestis	Cellular processes	Chemotaxis and motility

IDP90141 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_186	68449257		ser/thr protein kinase-like protein [Mon...	282	similar to VACV-COP-B12R, MPXV-ZAI96-B11R	Community Requests	2KTY	32.4%	Monkeypox virus

IDP05074 (show subtarget assignments)	1	cloned	No	lmo0135	16802183	-	hypothetical protein lmo0135 [Listeria m...	524	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	32.4%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP02786 (show subtarget assignments)	1	purified	No	Cj0322	15791690	perR	FUR family transcriptional regulator [Ca...	136	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2FE3	32.4%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00763 (show subtarget assignments)	1	expressed	No	SACOL0262	57286722		Ccholoylglycine hydrolase family protein...	330	Conserved Gene / Pathway	Phase 2: March 2008	2OQC	32.4%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP90208 (show subtarget assignments)	8	expressed	No	MYXV_gp143	9633775	m139R	m139R	188	Intracellular TLR and IL-1 signaling inhibitor, similar to VACV-Cop:A52R	Community Requests	2VVW	32.4%	Myxoma virus	host defense modulator	0

IDP01881 (show subtarget assignments)	1	cloned	No	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01397 (show subtarget assignments)	1	purified	No	VC0755	161582019		aminopeptidase B	429	Drug Target Function	Phase 2: March 2008	3H8E	32.4%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP90737 (show subtarget assignments)	8	expressed	No	YPO2523	16122742	menE	O-succinylbenzoic acid--CoA ligase [Yers...	471	Predicted Essential	Community Requests	3NYQ	32.4%	Yersinia pestis

IDP05153 (show subtarget assignments)	1	soluble	No	BA_0656	30254258		oligopeptide ABC transporter, oligopepti...	593	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRF	32.4%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00931 (show subtarget assignments)	1	expressed	No	STM0615	16763992	ybdR	putative dehydrogenase	412	Essential Gene	Phase 2: March 2008	1KOL	32.5%	Salmonella enterica	Central intermediary metabolism	Other

IDP90165 (show subtarget assignments)	8	purified	No	CD1834	123174271		3-phosphoshikimate 1-carboxyvinyltransfe...	437	Potential drug target. Shikimate pathway enzyme	Community Requests	3NVS	32.5%	Clostridium difficile

IDP05336 (show subtarget assignments)	1	soluble	No	Cj0799c	6968240	ruvA	hypothetical protein Cj0794 [Campylobact...	183	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	32.5%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP01435 (show subtarget assignments)	1	purified	No	VC1956	15641958		lytic murein transglycosylase, putative ...	323	Drug Target Function	Phase 2: March 2008	4ANR	32.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02620 (show subtarget assignments)	1	cloned	No	lmo0205	16802251	plcB	phospholipase C [Listeria monocytogenes ...	289	Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...	Phase 3: June 2008	1AH7	32.5%	Listeria monocytogenes	Cellular processes	Toxin production and resistance

IDP01316 (show subtarget assignments)	1	in_crystallization_trials	No	VC1616	15641624		glutaredoxin, putative	77	Conserved Gene / Pathway	Phase 2: March 2008	2KLX	32.5%	Vibrio cholerae	Energy metabolism	Electron transport

IDP02064 (show subtarget assignments)	1	cloned	No	YPO3878	16124011		putative fimbrial chaperone [Yersinia pe...	243	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.5%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP02807 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4705	47530004	tig	trigger factor [Bacillus anthracis str. ...	425	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1T11	32.5%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP05079 (show subtarget assignments)	1	cloned	No	lmo1438	16803478	-	hypothetical protein lmo1438 [Listeria m...	721	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2WAE	32.6%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05633 (show subtarget assignments)	1	purified	No	CD2177	126699793		amino-acid ABC transporter,substrate-bin...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2IEE	32.6%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP92109 (show subtarget assignments)	8	selected	No	TGME49_106930	237845137		proteasome subunit beta type 7, putative...	368	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1IRU	32.6%	Toxoplasma gondii

IDP00485 (show subtarget assignments)	1	purified	No	YPO1455	16121730		putative beta-ketoacyl-[acyl-carrier-pro...	427	Drug Target Function	Phase 2: March 2008	1J3N	32.6%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02282 (show subtarget assignments)	1	cloned	No	FTT0491c	56707633	gph	phosphoglycolate phosphatase [Francisell...	224	Drug Target	Phase 3: June 2008	2HSZ	32.6%	Francisella tularensis	Energy metabolism	Sugars

IDP05628 (show subtarget assignments)	1	soluble	No	CD1444	126699048		putative exported polysaccharide deacety...	239	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	32.6%	Clostridium difficile	Unknown function: General

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP01957 (show subtarget assignments)	1	expressed	No	STM1657	16765001		putative methyl-accepting chemotaxis pro...	384	Conserved; Drug target functions	Phase 3: June 2008	3ZX6	32.6%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP00083 (show subtarget assignments)	1	in_crystallization_trials	No	NTL01ST0073	16418570	caiA	putative acyl-CoA dehydrogenase, carniti...	380	Essential	Phase 1: October 2007	2DVL	32.6%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP02111 (show subtarget assignments)	1	in_crystallization_trials	No	STM3694	16766979	lldD	L-lactate dehydrogenase [Salmonella typh...	396	Conserved; Drug target functions	Phase 3: June 2008	1AL7	32.6%	Salmonella enterica	Energy metabolism	Aerobic

IDP00720 (show subtarget assignments)	1	cloned	No	SACOL1609	57286131	pbp3	penicillin-binding protein 3	691	Drug Target Function	Phase 2: March 2008	2WAF	32.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91214 (show subtarget assignments)	8	expressed	No	Blon_1597	189439474	aroB	bifunctional shikimate kinase/3-dehydroq...	540	potential drug target / Shikimate pathway enzyme	Community Requests	3QBD	32.6%	Bifidobacterium longum

IDP01066 (show subtarget assignments)	1	expressed	No	STM3819	16767104	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP91315 (show subtarget assignments)	8	expressed	No	VV2_0482	27366916		ABC-type bacteriocin/lantibiotic exporte...	535	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2HYD	32.7%	Vibrio vulnificus

IDP05514 (show subtarget assignments)	1	purified	No	CD1315	126698913	ribC	riboflavin biosynthesis protein [Clostri...	309	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MRZ	32.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91194 (show subtarget assignments)	8	cloned	No	BAS4090	49187088	-	Stage III sporulation protein AH	223	essential/virulence/pathogenesis / Essential proteins	Community Requests	3TUF	32.7%	Bacillus anthracis

IDP00478 (show subtarget assignments)	1	purified	No	YPO0469	16120798	dnaJ	chaperone protein DnaJ	379	Conserved Gene / Pathway	Phase 2: March 2008	3LZ8	32.7%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP90946
(show subtarget assignments)

8

cloned

No

BP1878

33592926

bvgA

virulence factors transcription regulato...

209

BvgA is the transcriptional activator for all known virulence genes in the human...

Community Requests

3C3W

31.6%

Bordetella pertussis

IDP02719
(show subtarget assignments)

1

cloned

No

lmo0262

16802308

inlG

internalin G [Listeria monocytogenes EGD...

490

Known virulence-Invasion; Predicted virulence-Invasion; PMID:11432815

Phase 3: June 2008

1M9S

31.6%

Listeria monocytogenes

Cellular processes

Pathogenesis

IDP01654
(show subtarget assignments)

1

expressed

No

STM1259

16764611

putative ABC-type transport system ATPas...

196

Conserved; Drug target functions

Phase 3: June 2008

1Z47

31.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP90167
(show subtarget assignments)

8

purified

No

CD1838

123066836

Shikimate kinase

177

Potential drug target. Shikimate pathway enzyme

Community Requests

2PT5

31.6%

Clostridium difficile

IDP91080
(show subtarget assignments)

8

cloned

No

Cj0803

6968244

msbA

lipid export ABC transport protein

580

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

31.6%

Campylobacter jejuni

IDP00709
(show subtarget assignments)

1

purified

No

SACOL0798

57285759

iron compound ABC transporter, ATP-bindi...

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

31.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01222
(show subtarget assignments)

1

purified

No

BA_4049

33301352

UDP-N-acetylglucosamine--N-acetylmuramyl...

364

Drug Target Function

Phase 2: March 2008

1F0K

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00634
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1722

57284733

tig

trigger factor

433

Drug Target Function

Phase 2: March 2008

1W26

31.6%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP05255
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0663

57650073

argS

arginyl-tRNA synthetase [Staphylococcus ...

553

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05228
(show subtarget assignments)

1

soluble

No

lmo0971

16803011

dltD

DltD protein for D-alanine esterificatio...

380

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3BMA

31.6%

Listeria monocytogenes

Cell envelope: Other

IDP02469
(show subtarget assignments)

1

cloned

No

FTT0573

56707702

alr

alanine racemase [Francisella tularensis...

365

Conserved; Drug target functions

Phase 3: June 2008

4A3Q

31.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90529
(show subtarget assignments)

8

soluble

No

YPO1127

16121427

nicA

quinolinate synthetase

353

Predicted Essential

Community Requests

2QS0

31.7%

Yersinia pestis

IDP00732
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2473

57286467

peptide ABC transporter, ATP-binding pro...

271

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

31.7%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP00724
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1822

57286255

arsR

arsenical resistance operon repressor

104

Conserved Gene / Pathway

Phase 2: March 2008

1R1T

31.7%

Staphylococcus aureus

Cellular processes

Detoxification

IDP00155
(show subtarget assignments)

1

in_crystallization_trials

No

VC0405

15640432

mshE

MSHA biogenesis protein MshE

575

Virulence

Phase 1: October 2007

1P9R

31.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP05766
(show subtarget assignments)

1

expressed

No

S0723

30040469

putative helicase [Shigella flexneri 2a ...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2R6A

31.7%

Shigella flexneri

DNA metabolism: DNA replication, recombination, and repair

IDP00518
(show subtarget assignments)

1

cloned

No

YPO1566

16121836

putative hydrolase

280

Virulence Associated Factor

Phase 2: March 2008

3QDF

31.8%

Yersinia pestis

Cellular processes

Toxin production and resistance

IDP04136
(show subtarget assignments)

1

diffraction

No

GBAA4258

47529551

5-methylthio-3-oxo-1-penten-1,2-diol dio...

170

putative drug target function;

Phase 4: April 2009

1ZRR

31.8%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP05453
(show subtarget assignments)

1

in_crystallization_trials

No

BAS5213

49188199

-

arginyl-tRNA synthetase [Bacillus anthra...

556

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.8%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP02376
(show subtarget assignments)

1

cloned

No

FTT0451

56707593

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

416

Conserved; Drug target functions

Phase 3: June 2008

1E0D

31.8%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00721
(show subtarget assignments)

1

expressed

No

SACOL1613

57286135

ABC transporter, ATP-binding protein

261

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

31.8%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP05504
(show subtarget assignments)

1

purified

No

CD0869

126698446

modA

putative molybdenum ABC transporter,subs...

270

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1AMF

31.9%

Clostridium difficile

Transport and binding proteins: Anions

IDP91089
(show subtarget assignments)

8

soluble

No

NT06FT0892

0

323

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

31.9%

Francisella tularensis

Energy metabolism: Sugars

IDP04262
(show subtarget assignments)

1

cloned

No

CPF_2067

110799430

spo0A

Spo0A protein [Clostridium perfringens A...

276

conserved gene; putative drug target function;

Phase 4: April 2009

1LQ1

31.9%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05085
(show subtarget assignments)

1

soluble

No

Z4863

12518151

putative 3-oxoacyl-[ACP] synthase [Esche...

389

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3KZU

31.9%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP90839
(show subtarget assignments)

8

purified

No

Cj0641

15792001

ATP-NAD kinase, putative [Campylobacter ...

286

Predicted Essential

Community Requests

2AN1

31.9%

Campylobacter jejuni

IDP04681
(show subtarget assignments)

1

soluble

No

GBAA3131

47528422

adhB

alcohol dehydrogenase, zinc-containing [...

377

virulence factor; putative drug target function;

Phase 4: April 2009

1KOL

31.9%

Bacillus anthracis

Energy metabolism

Fermentation

IDP91185
(show subtarget assignments)

8

cloned

No

AAC46367

2352978

477

virulence/pathogenesis / FlrC regulates flagellar synthesis in Vibrio cholerae, and my lab has determined...

Community Requests

1NY5

31.9%

Vibrio cholerae

IDP01879
(show subtarget assignments)

1

cloned

No

FTT1804c

56708790

rng

ribonuclease G [Francisella tularensis s...

498

Conserved; Drug target functions

Phase 3: June 2008

2BX2

31.9%

Francisella tularensis

Cellular processesTranscription

Cell divisionRNA processing

IDP00942
(show subtarget assignments)

1

in_crystallization_trials

No

STM0857

16764219

putative acyl-CoA dehydrogenase

387

Essential Gene

Phase 2: March 2008

3MPI

32%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP01953
(show subtarget assignments)

1

soluble

No

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP05722
(show subtarget assignments)

1

purified

No

BA_2954

30257545

tyrA

prephenate dehydrogenase [Bacillus anthr...

378

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DZB

32%

Bacillus anthracis

Amino acid biosynthesis: Aromatic amino acid family

IDP00704
(show subtarget assignments)

1

expressed

No

SACOL0264

57286724

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

32%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP05765
(show subtarget assignments)

1

soluble

No

lmo2812

16804849

-

hypothetical protein lmo2812 [Listeria m...

272

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IT9

32%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00330
(show subtarget assignments)

1

purified

No

Cj0345

15791713

trpE

putative anthranilate synthase component...

416

Drug Target Function

Phase 2: March 2008

1QDL

32%

Campylobacter jejuni

Amino acid biosynthesis

Aromatic amino acid family

IDP00614
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2109

57286325

modification methylase, HemK family

278

Drug Target Function

Phase 2: March 2008

1T43

32%

Staphylococcus aureus

Unknown function

General

IDP90352
(show subtarget assignments)

8

expressed

No

CT262

15604983

hypothetical protein CT262 [Chlamydia tr...

256

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2CZL

32%

Chlamydia trachomatis

IDP91279
(show subtarget assignments)

8

soluble

No

NT05BA4913

49181643

DNA-binding response regulator [Bacillus...

231

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2OQR

32%

Bacillus anthracis

IDP91070
(show subtarget assignments)

8

cloned

No

RP205

15604078

multidrug resistance transporter ATM1 [R...

609

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

32%

Rickettsia prowazekii

IDP91273
(show subtarget assignments)

8

soluble

No

NT05BA4146

49180892

conserved hypothetical protein TIGR00281...

190

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

2Z99

32.1%

Bacillus anthracis

IDP00119
(show subtarget assignments)

1

purified

No

NT01ST0753

16763999

citE

citrate lyase beta chain

302

Essential

Phase 1: October 2007

1SGJ

32.1%

Salmonella enterica

Energy metabolism

Fermentation

IDP02406
(show subtarget assignments)

1

crystallized

No

GBAA2768

47528059

thioredoxin reductase, putative [Bacillu...

301

Conserved; Essential; Drug target functions

Phase 3: June 2008

3FBS

32.1%

Bacillus anthracis

Energy metabolism

Electron transport

IDP02011
(show subtarget assignments)

1

cloned

No

STM2340

16765667

putative transketolase [Salmonella typhi...

317

Conserved; Drug target functions

Phase 3: June 2008

3MOS

32.1%

Salmonella enterica

Energy metabolism

Pentose phosphate pathway

IDP91989
(show subtarget assignments)

8

purified

No

SpneCM_010100010148

298255940

serine protease [Streptococcus pneumonia...

393

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1Y8T

32.1%

Streptococcus pneumoniae

IDP90197
(show subtarget assignments)

8

soluble

No

AAM13645.1

20153184

CPXV206 CDS

CPXV206 protein

285

serine-threonine kinase

Community Requests

2KTY

32.1%

Cowpox virus

Unknown function

0

IDP02168
(show subtarget assignments)

1

expressed

No

CBU_1289

29541857

dnaJ

chaperone protein dnaJ [Coxiella burneti...

374

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

32.1%

Coxiella burnetii

Protein fate

Protein folding and stabilization

IDP90654
(show subtarget assignments)

8

expressed

No

YPO0474

16120803

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Predicted Essential

Community Requests

1MRZ

32.1%

Yersinia pestis

IDP91074
(show subtarget assignments)

8

cloned

No

MSMEG_5659

118469658

ABC transporter, ATP-binding protein [My...

610

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

32.1%

Mycobacterium smegmatis

IDP05497
(show subtarget assignments)

1

cloned

No

CD0241

126697812

phosphoserine phosphatase [Clostridium d...

205

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F5S

32.1%

Clostridium difficile

Amino acid biosynthesis: Serine family

IDP04235
(show subtarget assignments)

1

cloned

No

CPF_0823

110800089

polysaccharide deacetylase family protei...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W3Z

32.1%

Clostridium perfringens

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP00897
(show subtarget assignments)

1

expressed

No

STM0771

16764135

putative ABC-type cobalamin/Fe3+-siderop...

258

Conserved Gene / Pathway

Phase 2: March 2008

2ONK

32.2%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP01885
(show subtarget assignments)

1

cloned

No

GBAA5639

47530965

D-alanyl-D-alanine carboxypeptidase, put...

423

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00728
(show subtarget assignments)

1

cloned

No

SACOL2210

57284991

ABC transporter, ATP-binding protein

286

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

32.2%

Staphylococcus aureus

Transport and binding proteins

Unknown substrate

IDP91072
(show subtarget assignments)

8

cloned

No

YPO2588

16122801

-

putative ABC transport protein

631

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

2HYD

32.2%

Yersinia pestis

IDP05100
(show subtarget assignments)

1

soluble

No

CD0876

126698453

ABC transporter, substrate-binding lipop...

345

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3LFT

32.2%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP02247
(show subtarget assignments)

1

expressed

No

FTT0665c

56707786

aldolase/adducin class II family protein...

201

Drug Target

Phase 3: June 2008

3OCR

32.3%

Francisella tularensis

Unknown function

General

IDP00058
(show subtarget assignments)

1

soluble

No

BA_3903

30258417

bacteriocin ABC transporter, ATP-binding...

234

Virulence

Phase 1: October 2007

1OXS

32.3%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP92112
(show subtarget assignments)

8

selected

No

TGME49_057730

237831419

methionine aminopeptidase, putative [Tox...

387

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2B3H

32.3%

Toxoplasma gondii

IDP04156
(show subtarget assignments)

1

expressed

No

VC0681

9655120

riboflavin kinase/FMN adenylyltransferas...

322

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1MRZ

32.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP05205
(show subtarget assignments)

1

cloned

No

CD1770

126699379

ogt2

methylated-DNA--protein-cysteine methylt...

164

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2G7H

32.3%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP02523
(show subtarget assignments)

1

cloned

No

GBAA4297

47529591

dacF

D-alanyl-D-alanine carboxypeptidase [Bac...

396

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IT9

32.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02228
(show subtarget assignments)

1

cloned

No

FTT1240c

56708302

hypothetical protein FTT1240c [Francisel...

182

Drug Target

Phase 3: June 2008

2P0T

32.4%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP00988
(show subtarget assignments)

1

expressed

No

STM2163

16765493

yehX

putative ABC-type proline/glycine betain...

315

Conserved Gene / Pathway

Phase 2: March 2008

1V43

32.4%

Salmonella enterica

Transport and binding proteins

Other

IDP00209
(show subtarget assignments)

1

soluble

No

YPO2062

16122301

-

putative M23/M37 peptidase-family protei...

417

Virulence

Phase 1: October 2007

2GU1

32.4%

Yersinia pestis

Cellular processes

Chemotaxis and motility

IDP90141
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_186

68449257

ser/thr protein kinase-like protein [Mon...

282

similar to VACV-COP-B12R, MPXV-ZAI96-B11R

Community Requests

2KTY

32.4%

Monkeypox virus

IDP05074
(show subtarget assignments)

1

cloned

No

lmo0135

16802183

-

hypothetical protein lmo0135 [Listeria m...

524

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

32.4%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP02786
(show subtarget assignments)

1

purified

No

Cj0322

15791690

perR

FUR family transcriptional regulator [Ca...

136

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2FE3

32.4%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00763
(show subtarget assignments)

1

expressed

No

SACOL0262

57286722

Ccholoylglycine hydrolase family protein...

330

Conserved Gene / Pathway

Phase 2: March 2008

2OQC

32.4%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP90208
(show subtarget assignments)

8

expressed

No

MYXV_gp143

9633775

m139R

188

Intracellular TLR and IL-1 signaling inhibitor, similar to VACV-Cop:A52R

Community Requests

2VVW

32.4%

Myxoma virus

host defense modulator

0

IDP01881
(show subtarget assignments)

1

cloned

No

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01397
(show subtarget assignments)

1

purified

No

VC0755

161582019

aminopeptidase B

429

Drug Target Function

Phase 2: March 2008

3H8E

32.4%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP90737
(show subtarget assignments)

8

expressed

No

YPO2523

16122742

menE

O-succinylbenzoic acid--CoA ligase [Yers...

471

Predicted Essential

Community Requests

3NYQ

32.4%

Yersinia pestis

IDP05153
(show subtarget assignments)

1

soluble

No

BA_0656

30254258

oligopeptide ABC transporter, oligopepti...

593

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRF

32.4%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00931
(show subtarget assignments)

1

expressed

No

STM0615

16763992

ybdR

putative dehydrogenase

412

Essential Gene

Phase 2: March 2008

1KOL

32.5%

Salmonella enterica

Central intermediary metabolism

Other

IDP90165
(show subtarget assignments)

8

purified

No

CD1834

123174271

3-phosphoshikimate 1-carboxyvinyltransfe...

437

Potential drug target. Shikimate pathway enzyme

Community Requests

3NVS

32.5%

Clostridium difficile

IDP05336
(show subtarget assignments)

1

soluble

No

Cj0799c

6968240

ruvA

hypothetical protein Cj0794 [Campylobact...

183

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

32.5%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP01435
(show subtarget assignments)

1

purified

No

VC1956

15641958

lytic murein transglycosylase, putative ...

323

Drug Target Function

Phase 2: March 2008

4ANR

32.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02620
(show subtarget assignments)

1

cloned

No

lmo0205

16802251

plcB

phospholipase C [Listeria monocytogenes ...

289

Known virulence-Enzyme ; Predicted virulence-Pathogenicity islands; PMID:1143281...

Phase 3: June 2008

1AH7

32.5%

Listeria monocytogenes

Cellular processes

Toxin production and resistance

IDP01316
(show subtarget assignments)

1

in_crystallization_trials

No

VC1616

15641624

glutaredoxin, putative

77

Conserved Gene / Pathway

Phase 2: March 2008

2KLX

32.5%

Vibrio cholerae

Energy metabolism

Electron transport

IDP02064
(show subtarget assignments)

1

cloned

No

YPO3878

16124011

putative fimbrial chaperone [Yersinia pe...

243

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.5%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP02807
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4705

47530004

tig

trigger factor [Bacillus anthracis str. ...

425

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1T11

32.5%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP05079
(show subtarget assignments)

1

cloned

No

lmo1438

16803478

-

hypothetical protein lmo1438 [Listeria m...

721

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2WAE

32.6%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05633
(show subtarget assignments)

1

purified

No

CD2177

126699793

amino-acid ABC transporter,substrate-bin...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2IEE

32.6%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP92109
(show subtarget assignments)

8

selected

No

TGME49_106930

237845137

proteasome subunit beta type 7, putative...

368

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1IRU

32.6%

Toxoplasma gondii

IDP00485
(show subtarget assignments)

1

purified

No

YPO1455

16121730

putative beta-ketoacyl-[acyl-carrier-pro...

427

Drug Target Function

Phase 2: March 2008

1J3N

32.6%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP02282
(show subtarget assignments)

1

cloned

No

FTT0491c

56707633

gph

phosphoglycolate phosphatase [Francisell...

224

Drug Target

Phase 3: June 2008

2HSZ

32.6%

Francisella tularensis

Energy metabolism

Sugars

IDP05628
(show subtarget assignments)

1

soluble

No

CD1444

126699048

putative exported polysaccharide deacety...

239

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

32.6%

Clostridium difficile

Unknown function: General

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP01957
(show subtarget assignments)

1

expressed

No

STM1657

16765001

putative methyl-accepting chemotaxis pro...

384

Conserved; Drug target functions

Phase 3: June 2008

3ZX6

32.6%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP00083
(show subtarget assignments)

1

in_crystallization_trials

No

NTL01ST0073

16418570

caiA

putative acyl-CoA dehydrogenase, carniti...

380

Essential

Phase 1: October 2007

2DVL

32.6%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP02111
(show subtarget assignments)

1

in_crystallization_trials

No

STM3694

16766979

lldD

L-lactate dehydrogenase [Salmonella typh...

396

Conserved; Drug target functions

Phase 3: June 2008

1AL7

32.6%

Salmonella enterica

Energy metabolism

Aerobic

IDP00720
(show subtarget assignments)

1

cloned

No

SACOL1609

57286131

pbp3

penicillin-binding protein 3

691

Drug Target Function

Phase 2: March 2008

2WAF

32.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91214
(show subtarget assignments)

8

expressed

No

Blon_1597

189439474

aroB

bifunctional shikimate kinase/3-dehydroq...

540

potential drug target / Shikimate pathway enzyme

Community Requests

3QBD

32.6%

Bifidobacterium longum

IDP01066
(show subtarget assignments)

1

expressed

No

STM3819

16767104

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP91315
(show subtarget assignments)

8

expressed

No

VV2_0482

27366916

ABC-type bacteriocin/lantibiotic exporte...

535

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2HYD

32.7%

Vibrio vulnificus

IDP05514
(show subtarget assignments)

1

purified

No

CD1315

126698913

ribC

riboflavin biosynthesis protein [Clostri...

309

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MRZ

32.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP91194
(show subtarget assignments)

8

cloned

No

BAS4090

49187088

-

Stage III sporulation protein AH

223

essential/virulence/pathogenesis / Essential proteins

Community Requests

3TUF

32.7%

Bacillus anthracis

IDP00478
(show subtarget assignments)

1

purified

No

YPO0469

16120798

dnaJ

chaperone protein DnaJ

379

Conserved Gene / Pathway

Phase 2: March 2008

3LZ8

32.7%

Yersinia pestis

Protein fate

Protein folding and stabilization