Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02140 (show subtarget assignments)	1	cloned	No	YPO1629	16121897		N-acetyl-D-glucosamine kinase [Yersinia ...	256	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2AP1	60.2%	Yersinia pestis	Unknown function	General

IDP02578 (show subtarget assignments)	1	expressed	No	STM0262	16763645	yafS	putative SAM-dependent methyltransferase...	240	Conserved; Drug target functions	Phase 3: June 2008	1VLM	11.7%	Salmonella enterica	Unknown function	General

IDP00139 (show subtarget assignments)	1	crystallized	No	BA_4355	30258855	argC	N-acetyl-gamma-glutamyl-phosphate reduct...	345	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1VKN	40.5%	Bacillus anthracis	Unknown function	General

IDP01873 (show subtarget assignments)	1	cloned	No	FTT0917	56708018	maeA	malate dehydrogenase [Francisella tulare...	604	Drug Target	Phase 3: June 2008	2AW5	34.8%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP02120 (show subtarget assignments)	1	expressed	No	YPO0027	16120380		phosphatase [Yersinia pestis CO92]	196	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2B0C	66.8%	Yersinia pestis	Unknown function	General

IDP02104 (show subtarget assignments)	1	soluble	No	YPO1074	16121375		D,D-heptose 1,7-bisphosphate phosphatase...	188	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2GMW	80.9%	Yersinia pestis	Unknown function	General

IDP02573 (show subtarget assignments)	1	in_pdb 3ICC	No	GBAA1847	47527139		short chain dehydrogenase [Bacillus anth...	252	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3ICC	100%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP00614 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2109	57286325		modification methylase, HemK family	278	Drug Target Function	Phase 2: March 2008	1T43	32%	Staphylococcus aureus	Unknown function	General

IDP02100 (show subtarget assignments)	1	soluble	No	STM3610	16766896	yhjG	putative inner membrane protein [Salmone...	686	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP02117 (show subtarget assignments)	1	in_crystallization_trials	No	STM4356	16767602	yjeF	hypothetical protein STM4356 [Salmonella...	515	Conserved; Drug target functions	Phase 3: June 2008	2AX3	31.3%	Salmonella enterica	Unknown function	General

IDP01833 (show subtarget assignments)	1	cloned	No	STM2476	16765796	ypfG	putative periplasmic protein [Salmonella...	347	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unknown function	General

IDP00606 (show subtarget assignments)	1	cloned	No	SACOL1933	57286280		ThiJ/PfpI family protein	171	Drug Target Function	Phase 2: March 2008	1OI4	48.8%	Staphylococcus aureus	Unknown function	General

IDP01838 (show subtarget assignments)	1	cloned	No	STM0941	16764303	ybjY	macrolide transporter subunit MacA [Salm...	372	Conserved; Drug target functions	Phase 3: June 2008	3FPP	79%	Salmonella enterica	Unknown function	General

IDP01880 (show subtarget assignments)	1	in_pdb 3N77 3OGA	Yes	STM2295	16765622	yfaO	putative NTP pyrophosphohydrolase [Salmo...	141	Conserved; Drug target functions	Phase 3: June 2008	3OGA	100%	Salmonella enterica	Unknown function	General

IDP90209 (show subtarget assignments)	8	expressed	No	MYXV_gp144	9633776	m140R	m140R	553	kelch motif, similar to VACV-Cop:A55R	Community Requests	1U6D	14.3%	Myxoma virus	unknown, conserved protein	0

IDP90210 (show subtarget assignments)	8	expressed	No	MYXV_gp140	9633772	m136R	m136R	179	unknown, similar to VACV-Cop:A52R	Community Requests	2VVW	20.1%	Myxoma virus	unknown, conserved protein	0

IDP90219 (show subtarget assignments)	8	expressed	No	MYXV_gp011	9633802	m008L	m008L, m8	515	contains kelch motifs, similar to MYX-L-m006R	Community Requests	2XN4	11.5%	Myxoma virus	unknown	0

IDP90215 (show subtarget assignments)	8	expressed	No	MYXV_gp009	9633800	m006L	m006L, m6	509	contains kelch motifs, similar to MYX-L-m006R	Community Requests	1X2J	13.9%	Myxoma virus	unknown	0

IDP90217 (show subtarget assignments)	8	soluble	No	MYXV_gp004	9633795	m003.1L	m003.1L, m3.1	151	similar to VACV-Cop:B22R, member of Poxvirus A4/B15 family. This is a family of ...	Community Requests	2VVY	29.8%	Myxoma virus	unknown	0

IDP90214 (show subtarget assignments)	8	expressed	No	MYXV_gp017	9633649	m013L	m013L, M013L	126	interferon inducible protein	Community Requests			Myxoma virus	unknown	0

IDP05434 (show subtarget assignments)	1	soluble	No	lmo1913	16803952	-	hypothetical protein lmo1913 [Listeria m...	334	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3REN	19.2%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05425 (show subtarget assignments)	1	soluble	No	lmo0355	16802400	-	fumarate reductase flavoprotein subunit ...	506	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1D4C	40.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05563 (show subtarget assignments)	1	soluble	No	lmo2417	16804455	-	hypothetical protein lmo2417 [Listeria m...	276	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EF1	50.4%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05246 (show subtarget assignments)	1	soluble	No	lmo2439	16804477	-	hypothetical protein lmo2439 [Listeria m...	113	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K5Q	33.6%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05547 (show subtarget assignments)	1	soluble	No	lmo0285	16802331	-	putative lipoprotein [Listeria monocytog...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TQW	41%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05077 (show subtarget assignments)	1	cloned	No	lmo1115	16803155	-	hypothetical protein lmo1115 [Listeria m...	873	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05231 (show subtarget assignments)	1	purified	No	lmo1388	16803428	tcsA	CD4+ T cell-stimulating antigen, lipopro...	346	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	39.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP91278 (show subtarget assignments)	8	cloned	No	NT05BA4419	49181159		RNA polymerase sigma-27 factor [Bacillus...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L9U	30.8%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP05755 (show subtarget assignments)	1	expressed	No	lmo0732	16802774	-	peptidoglycan binding protein [Listeria ...	638	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3RGX	17.6%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05756 (show subtarget assignments)	1	cloned	No	lmo0814	16802856	-	hypothetical protein lmo0814 [Listeria m...	309	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3BO9	50.2%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05752 (show subtarget assignments)	1	selected	No	lmo0435	16802479	-	peptidoglycan binding protein [Listeria ...	2013	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05761 (show subtarget assignments)	1	cloned	No	lmo2125	16804164	-	hypothetical protein lmo2125 [Listeria m...	419	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2XD2	49.6%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05192 (show subtarget assignments)	1	cloned	No	CD0332	126697904	bclA1	putative exosporium glycoprotein [Clostr...	693	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	24.4%	Clostridium difficile	Unclassified: Role category not yet assigned

IDP91281 (show subtarget assignments)	8	expressed	No	NT05BA5437	49182125		RNA polymerase sigma-70 factor, ECF subf...	175	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1OR7	22.5%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP05701 (show subtarget assignments)	1	soluble	No	lmo2522	16804560	-	hypothetical protein lmo2522 [Listeria m...	277	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05696 (show subtarget assignments)	1	expressed	No	lmo2170	16804209	-	hypothetical protein lmo2170 [Listeria m...	309	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3BO9	48.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05698 (show subtarget assignments)	1	cloned	No	lmo2186	16804225	-	hypothetical protein lmo2186 [Listeria m...	207	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2O6P	26.1%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05684 (show subtarget assignments)	1	in_pdb 3TNG 3U9E 3UF6	No	lmo1369	16803409	-	hypothetical protein lmo1369 [Listeria m...	288	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3TNG	100%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05682 (show subtarget assignments)	1	cloned	No	lmo1303	16803343	-	hypothetical protein lmo1303 [Listeria m...	109	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05024 (show subtarget assignments)	1	soluble	No	BAS4675	49187666	-	ABC transporter, substrate-binding prote...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	20.6%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP05444 (show subtarget assignments)	1	soluble	No	lmo0768	16802810	-	hypothetical protein lmo0768 [Listeria m...	417	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	26.4%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP05644 (show subtarget assignments)	1	cloned	No	CD3230	126700850	bclA2	exosporium glycoprotein [Clostridium dif...	558	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HQV	35.3%	Clostridium difficile	Unclassified: Role category not yet assigned

IDP05657 (show subtarget assignments)	1	cloned	No	lmo0175	16802221	-	peptidoglycan binding protein [Listeria ...	415	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KT7	8.2%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP91265 (show subtarget assignments)	8	cloned	No	NT05BA1551	49178367		2-heptaprenyl-1,4-naphthoquinone methylt...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VE3	24.9%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP04720 (show subtarget assignments)	1	expressed	No	YPO1174	115346948		hypothetical protein [Yersinia pestis CO...	309	virulence factor; putative drug target function;	Phase 4: April 2009	3ULT	12.6%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00267 (show subtarget assignments)	1	cloned	No	AAX48017_4-113	61652905	N/A	Capsid protein (C)	111	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.4%	Dengue virus	Unclassified	N/A

IDP04729 (show subtarget assignments)	1	cloned	No	YPO0515	115346325		putative membrane protein [Yersinia pest...	1150	virulence factor; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Unclassified	Role category not yet assigned

IDP02502 (show subtarget assignments)	1	expressed	No	Cj1341c	15792664		hypothetical protein Cj1341c [Campylobac...	607	Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950	Phase 3: June 2008			Campylobacter jejuni	Unclassified	Role category not yet assigned

IDP00263 (show subtarget assignments)	1	cloned	No	AF180817_1-114	7329982	N/A	Capsid protein (C)	114	Encapsidation of genomic RNA	Phase 3: June 2008	1R6R	60.5%	Dengue virus	Unclassified	N/A

IDP02495 (show subtarget assignments)	1	cloned	No	Cj1565c	15792870	pflA	paralyzed flagella protein PflA [Campylo...	788	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Unclassified	Unclassified

IDP04723 (show subtarget assignments)	1	cloned	No	YPO1364	115347123		putative HlyD family secretion protein [...	371	conserved gene; putative drug target function;	Phase 4: April 2009	3FPP	62.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02508 (show subtarget assignments)	1	cloned	No	lmo1847	16803887		hypothetical protein lmo1847 [Listeria m...	310	Known virulence-Invasion; PMID:12496198	Phase 3: June 2008	1PSZ	52.3%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP04129 (show subtarget assignments)	1	expressed	No	YPO0764	115346558		conserved hypothetical protein [Yersinia...	741	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	16.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04121 (show subtarget assignments)	1	cloned	No	YPO2725	115348408		conserved hypothetical protein [Yersinia...	921	virulence factor; putative drug target function;	Phase 4: April 2009	2P5Z	12.6%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02068 (show subtarget assignments)	1	crystallized	No	YPO3194	16123356	ahpC	putative alkyl hydroperoxide reductase s...	200	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1ZOF	59%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP04291 (show subtarget assignments)	1	expressed	No	YPO3603	115349224		putative exported protein [Yersinia pest...	1177	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Unclassified	Role category not yet assigned

IDP00996 (show subtarget assignments)	1	in_crystallization_trials	No	STM2310	16765637	menF	menaquinone-specific isochorismate synth...	431	Drug Target Function	Phase 2: March 2008	2EUA	78.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01848 (show subtarget assignments)	1	cloned	No	FTT1754	56708752	pta	phosphate acetyltransferase [Francisella...	698	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1TD9	19.9%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP04094 (show subtarget assignments)	1	expressed	No	YPO1966	218929080	astE	succinylglutamate desuccinylase [Yersini...	330	conserved gene; putative drug target function;	Phase 4: April 2009	1YW6	47.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00515 (show subtarget assignments)	1	cloned	No	YPO3922	16124053		hemophore HasA	205	Virulence Associated Factor	Phase 2: March 2008	1B2V	29.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP00512 (show subtarget assignments)	1	cloned	No	YPO2244	16122472		electron transport complex protein RnfC ...	620	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Unclassified	Role category not yet assigned

IDP02459 (show subtarget assignments)	1	soluble	No	lmo2067	16804106		hypothetical protein lmo2067 [Listeria m...	325	Known virulence-Bile resistance; PMID:15664931	Phase 3: June 2008	2BJF	38.8%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP00217 (show subtarget assignments)	1	cloned	No	YPO2319	16122543	-	putative pepetidase	278	Virulence	Phase 1: October 2007	1AGJ	24.1%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02044 (show subtarget assignments)	1	expressed	No	FTT1132c	56708208	glpQ	glycerophosphoryl diester phosphodiester...	250	Drug Target	Phase 3: June 2008	1O1Z	28%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP04108 (show subtarget assignments)	1	expressed	No	YPO0507	115346316		conserved hypothetical protein [Yersinia...	782	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2P5Z	13.7%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02419 (show subtarget assignments)	1	purified	No	FTT1447c	56708489	manB	phosphomannomutase [Francisella tularens...	494	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	2F7L	25.7%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP00483 (show subtarget assignments)	1	expressed	No	YPO1316	16121598		putative iron/ascorbate oxidoreductase f...	355	Virulence Associated Factor	Phase 2: March 2008	3OOX	25.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01825 (show subtarget assignments)	1	cloned	No	STM2265	16765593	ada	O6-methylguanine-DNA methyltransferase/t...	353	Conserved; Drug target functions	Phase 3: June 2008	1SFE	37.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01819 (show subtarget assignments)	1	cloned	No	STM1145	16764501	csgC	putative autoagglutination protein [Salm...	108	Conserved; Drug target functions	Phase 3: June 2008	2Y2T	64.8%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01814 (show subtarget assignments)	1	expressed	No	STM1753	16765097	hnr	response regulator of RpoS [Salmonella t...	337	Conserved; Drug target functions	Phase 3: June 2008	3EOD	35.3%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02408 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1418	16121698		23S rRNA m(2)G2445 methyltransferase [Ye...	706	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3V8V	74.8%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP01923 (show subtarget assignments)	1	crystallized	No	STM1595	16764939	srfC	putative virulence protein [Salmonella t...	714	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP01845 (show subtarget assignments)	1	cloned	No	STM0017	16763407		hypothetical protein STM0017 [Salmonella...	147	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP00466 (show subtarget assignments)	1	cloned	No	YPO1536	16121809		putative iron-siderophore transport syst...	359	Conserved Gene / Pathway	Phase 2: March 2008	3MWF	12.3%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02397 (show subtarget assignments)	1	purified	No	FTT1326	56708383	udp	uridine phosphorylase [Francisella tular...	267	Drug Target	Phase 3: June 2008	3O6V	43.1%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02025 (show subtarget assignments)	1	cloned	No	lmo0394	16802439		hypothetical protein lmo0394 [Listeria m...	227	Possible Vaccine Candidate; Presence of Protease Motifs	Phase 3: June 2008	2XIV	19.8%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP01748 (show subtarget assignments)	1	soluble	No	PSLT011	17233476	srgA	putative thiol-disulfide isomerase or th...	217	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	3L9V	85.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01732 (show subtarget assignments)	1	cloned	No	STM1243	16764598		cold shock-like protein [Salmonella typh...	70	Conserved; Drug target functions	Phase 3: June 2008	2L15	48.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01907 (show subtarget assignments)	1	in_crystallization_trials	No	STM1160	16764516	solA	N-methyltryptophan oxidase [Salmonella t...	372	Conserved; Drug target functions	Phase 3: June 2008	2UZZ	83.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02817 (show subtarget assignments)	1	cloned	No	lmo2185	16804224		hypothetical protein lmo2185 [Listeria m...	569	Known virulence-Intracellular Survival; Predicted virulence-Iron Scavenging Mech...	Phase 3: June 2008	2O6P	8.4%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP02013 (show subtarget assignments)	1	cloned	No	STM2395	16765721	pgtE	outer membrane protease [Salmonella typh...	312	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	2X55	69.9%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01843 (show subtarget assignments)	1	cloned	No	lmo0204	16802250	actA	actin-assembly inducing protein precurso...	639	Known virulence-Nucleation-promoting factor; Predicted virulence-Pathogenicity i...	Phase 3: June 2008			Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP00442 (show subtarget assignments)	1	soluble	No	YPO2211	16122439	trpH	hypothetical protein YPO2211	299	Conserved Gene / Pathway	Phase 2: March 2008	2YB1	38.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02002 (show subtarget assignments)	1	in_pdb 4E4Y	No	FTT1014c	56708103		short chain dehydrogenase family protein...	241	Drug Target	Phase 3: June 2008	4E4Y	100%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02345 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1220	56708282		5-formyltetrahydroformate cycloligase fa...	182	Drug Target	Phase 3: June 2008	2JCB	28.6%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP01902 (show subtarget assignments)	1	soluble	No	STM0878	16764240	potG	putrescine transporter ATP-binding subun...	377	Conserved; Drug target functions	Phase 3: June 2008	1V43	38.7%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP02352 (show subtarget assignments)	1	cloned	No	FTT1334c	56708390		hypothetical protein FTT1334c [Francisel...	169	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP01900 (show subtarget assignments)	1	purified	No	STM0570	16763947	apeE	outer membrane esterase [Salmonella typh...	656	Drug target functions	Phase 3: June 2008	3KVN	25.5%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01657 (show subtarget assignments)	1	cloned	No	YPO3061	16123238	dapX	lipoprotein [Yersinia pestis CO92]	352	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3TGO	56.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02774 (show subtarget assignments)	1	soluble	No	FTT0392c	56707541		hypothetical protein FTT0392c [Francisel...	109	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP01654 (show subtarget assignments)	1	expressed	No	STM1259	16764611		putative ABC-type transport system ATPas...	196	Conserved; Drug target functions	Phase 3: June 2008	1Z47	31.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01905 (show subtarget assignments)	1	cloned	No	STM1113	16764471	scsA	suppression of copper sensitivity protei...	120	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP01898 (show subtarget assignments)	1	expressed	No	STM1669	16765012		invasin-like protein [Salmonella typhimu...	660	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Unclassified	Role category not yet assigned

IDP02308 (show subtarget assignments)	1	expressed	No	FTT1400c	56708448		hypothetical protein FTT1400c [Francisel...	128	Drug Target	Phase 3: June 2008			Francisella tularensis	Unclassified	Role category not yet assigned

IDP02281 (show subtarget assignments)	1	cloned	No	YPO1305	16121587	psaC	outer membrane usher protein PsaC precur...	837	Conserved; CD; Involved in virulence; Drug target functions	Phase 3: June 2008	3RFZ	36.5%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02705 (show subtarget assignments)	1	cloned	No	lmo0202	16802248	hly	listeriolysin O precursor [Listeria mono...	529	Known virulence-Toxin; Predicted virulence-Pathogenicity islands; PMID:11901162	Phase 3: June 2008	3HVN	41%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP02690 (show subtarget assignments)	1	cloned	No	FTT0954c	56708048		hypothetical protein FTT0954c [Francisel...	106	Drug Target	Phase 3: June 2008	1Y2I	36.8%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP02256 (show subtarget assignments)	1	purified	No	YPO1262	16121548		nucleoid-associated protein NdpA [Yersin...	334	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Unclassified	Role category not yet assigned

IDP04467 (show subtarget assignments)	1	soluble	No	YPO2174	218929273		putative nucleotide sugar dehydrogenase ...	448	virulence factor; putative drug target function;	Phase 4: April 2009	2Y0E	57.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP02663 (show subtarget assignments)	1	in_crystallization_trials	No	lmo2182	16804221		hypothetical protein lmo2182 [Listeria m...	259	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2GHI	30.9%	Listeria monocytogenes	Unclassified	Role category not yet assigned

IDP02140
(show subtarget assignments)

1

cloned

No

YPO1629

16121897

N-acetyl-D-glucosamine kinase [Yersinia ...

256

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2AP1

60.2%

Yersinia pestis

Unknown function

General

IDP02578
(show subtarget assignments)

1

expressed

No

STM0262

16763645

yafS

putative SAM-dependent methyltransferase...

240

Conserved; Drug target functions

Phase 3: June 2008

1VLM

11.7%

Salmonella enterica

Unknown function

General

IDP00139
(show subtarget assignments)

1

crystallized

No

BA_4355

30258855

argC

N-acetyl-gamma-glutamyl-phosphate reduct...

345

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1VKN

40.5%

Bacillus anthracis

Unknown function

General

IDP01873
(show subtarget assignments)

1

cloned

No

FTT0917

56708018

maeA

malate dehydrogenase [Francisella tulare...

604

Drug Target

Phase 3: June 2008

2AW5

34.8%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP02120
(show subtarget assignments)

1

expressed

No

YPO0027

16120380

phosphatase [Yersinia pestis CO92]

196

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2B0C

66.8%

Yersinia pestis

Unknown function

General

IDP02104
(show subtarget assignments)

1

soluble

No

YPO1074

16121375

D,D-heptose 1,7-bisphosphate phosphatase...

188

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2GMW

80.9%

Yersinia pestis

Unknown function

General

IDP02573
(show subtarget assignments)

1

in_pdb
3ICC

No

GBAA1847

47527139

short chain dehydrogenase [Bacillus anth...

252

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3ICC

100%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP00614
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2109

57286325

modification methylase, HemK family

278

Drug Target Function

Phase 2: March 2008

1T43

32%

Staphylococcus aureus

Unknown function

General

IDP02100
(show subtarget assignments)

1

soluble

No

STM3610

16766896

yhjG

putative inner membrane protein [Salmone...

686

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP02117
(show subtarget assignments)

1

in_crystallization_trials

No

STM4356

16767602

yjeF

hypothetical protein STM4356 [Salmonella...

515

Conserved; Drug target functions

Phase 3: June 2008

2AX3

31.3%

Salmonella enterica

Unknown function

General

IDP01833
(show subtarget assignments)

1

cloned

No

STM2476

16765796

ypfG

putative periplasmic protein [Salmonella...

347

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unknown function

General

IDP00606
(show subtarget assignments)

1

cloned

No

SACOL1933

57286280

ThiJ/PfpI family protein

171

Drug Target Function

Phase 2: March 2008

1OI4

48.8%

Staphylococcus aureus

Unknown function

General

IDP01838
(show subtarget assignments)

1

cloned

No

STM0941

16764303

ybjY

macrolide transporter subunit MacA [Salm...

372

Conserved; Drug target functions

Phase 3: June 2008

3FPP

79%

Salmonella enterica

Unknown function

General

IDP01880
(show subtarget assignments)

1

in_pdb
3N77
3OGA

Yes

STM2295

16765622

yfaO

putative NTP pyrophosphohydrolase [Salmo...

141

Conserved; Drug target functions

Phase 3: June 2008

3OGA

100%

Salmonella enterica

Unknown function

General

IDP90209
(show subtarget assignments)

8

expressed

No

MYXV_gp144

9633776

m140R

553

kelch motif, similar to VACV-Cop:A55R

Community Requests

1U6D

14.3%

Myxoma virus

unknown, conserved protein

0

IDP90210
(show subtarget assignments)

8

expressed

No

MYXV_gp140

9633772

m136R

179

unknown, similar to VACV-Cop:A52R

Community Requests

2VVW

20.1%

Myxoma virus

unknown, conserved protein

0

IDP90219
(show subtarget assignments)

8

expressed

No

MYXV_gp011

9633802

m008L

m008L, m8

515

contains kelch motifs, similar to MYX-L-m006R

Community Requests

2XN4

11.5%

Myxoma virus

unknown

0

IDP90215
(show subtarget assignments)

8

expressed

No

MYXV_gp009

9633800

m006L

m006L, m6

509

contains kelch motifs, similar to MYX-L-m006R

Community Requests

1X2J

13.9%

Myxoma virus

unknown

0

IDP90217
(show subtarget assignments)

8

soluble

No

MYXV_gp004

9633795

m003.1L

m003.1L, m3.1

151

Community Requests

2VVY

29.8%

Myxoma virus

unknown

0

IDP90214
(show subtarget assignments)

8

expressed

No

MYXV_gp017

9633649

m013L

m013L, M013L

126

interferon inducible protein

Community Requests

Myxoma virus

unknown

0

IDP05434
(show subtarget assignments)

1

soluble

No

lmo1913

16803952

-

hypothetical protein lmo1913 [Listeria m...

334

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3REN

19.2%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05425
(show subtarget assignments)

1

soluble

No

lmo0355

16802400

-

fumarate reductase flavoprotein subunit ...

506

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1D4C

40.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05563
(show subtarget assignments)

1

soluble

No

lmo2417

16804455

-

hypothetical protein lmo2417 [Listeria m...

276

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EF1

50.4%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05246
(show subtarget assignments)

1

soluble

No

lmo2439

16804477

-

hypothetical protein lmo2439 [Listeria m...

113

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K5Q

33.6%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05547
(show subtarget assignments)

1

soluble

No

lmo0285

16802331

-

putative lipoprotein [Listeria monocytog...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TQW

41%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05077
(show subtarget assignments)

1

cloned

No

lmo1115

16803155

-

hypothetical protein lmo1115 [Listeria m...

873

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05231
(show subtarget assignments)

1

purified

No

lmo1388

16803428

tcsA

CD4+ T cell-stimulating antigen, lipopro...

346

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

39.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP91278
(show subtarget assignments)

8

cloned

No

NT05BA4419

49181159

RNA polymerase sigma-27 factor [Bacillus...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L9U

30.8%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP05755
(show subtarget assignments)

1

expressed

No

lmo0732

16802774

-

peptidoglycan binding protein [Listeria ...

638

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3RGX

17.6%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05756
(show subtarget assignments)

1

cloned

No

lmo0814

16802856

-

hypothetical protein lmo0814 [Listeria m...

309

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3BO9

50.2%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05752
(show subtarget assignments)

1

selected

No

lmo0435

16802479

-

peptidoglycan binding protein [Listeria ...

2013

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05761
(show subtarget assignments)

1

cloned

No

lmo2125

16804164

-

hypothetical protein lmo2125 [Listeria m...

419

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2XD2

49.6%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05192
(show subtarget assignments)

1

cloned

No

CD0332

126697904

bclA1

putative exosporium glycoprotein [Clostr...

693

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

24.4%

Clostridium difficile

Unclassified: Role category not yet assigned

IDP91281
(show subtarget assignments)

8

expressed

No

NT05BA5437

49182125

RNA polymerase sigma-70 factor, ECF subf...

175

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1OR7

22.5%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP05701
(show subtarget assignments)

1

soluble

No

lmo2522

16804560

-

hypothetical protein lmo2522 [Listeria m...

277

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05696
(show subtarget assignments)

1

expressed

No

lmo2170

16804209

-

hypothetical protein lmo2170 [Listeria m...

309

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3BO9

48.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05698
(show subtarget assignments)

1

cloned

No

lmo2186

16804225

-

hypothetical protein lmo2186 [Listeria m...

207

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2O6P

26.1%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05684
(show subtarget assignments)

1

in_pdb
3TNG
3U9E
3UF6

No

lmo1369

16803409

-

hypothetical protein lmo1369 [Listeria m...

288

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3TNG

100%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05682
(show subtarget assignments)

1

cloned

No

lmo1303

16803343

-

hypothetical protein lmo1303 [Listeria m...

109

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05024
(show subtarget assignments)

1

soluble

No

BAS4675

49187666

-

ABC transporter, substrate-binding prote...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

20.6%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP05444
(show subtarget assignments)

1

soluble

No

lmo0768

16802810

-

hypothetical protein lmo0768 [Listeria m...

417

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

26.4%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP05644
(show subtarget assignments)

1

cloned

No

CD3230

126700850

bclA2

exosporium glycoprotein [Clostridium dif...

558

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HQV

35.3%

Clostridium difficile

Unclassified: Role category not yet assigned

IDP05657
(show subtarget assignments)

1

cloned

No

lmo0175

16802221

-

peptidoglycan binding protein [Listeria ...

415

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KT7

8.2%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP91265
(show subtarget assignments)

8

cloned

No

NT05BA1551

49178367

2-heptaprenyl-1,4-naphthoquinone methylt...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VE3

24.9%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP04720
(show subtarget assignments)

1

expressed

No

YPO1174

115346948

hypothetical protein [Yersinia pestis CO...

309

virulence factor; putative drug target function;

Phase 4: April 2009

3ULT

12.6%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00267
(show subtarget assignments)

1

cloned

No

AAX48017_4-113

61652905

N/A

Capsid protein (C)

111

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.4%

Dengue virus

Unclassified

N/A

IDP04729
(show subtarget assignments)

1

cloned

No

YPO0515

115346325

putative membrane protein [Yersinia pest...

1150

virulence factor; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02502
(show subtarget assignments)

1

expressed

No

Cj1341c

15792664

hypothetical protein Cj1341c [Campylobac...

607

Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950

Phase 3: June 2008

Campylobacter jejuni

Unclassified

Role category not yet assigned

IDP00263
(show subtarget assignments)

1

cloned

No

AF180817_1-114

7329982

N/A

Capsid protein (C)

114

Encapsidation of genomic RNA

Phase 3: June 2008

1R6R

60.5%

Dengue virus

Unclassified

N/A

IDP02495
(show subtarget assignments)

1

cloned

No

Cj1565c

15792870

pflA

paralyzed flagella protein PflA [Campylo...

788

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Unclassified

IDP04723
(show subtarget assignments)

1

cloned

No

YPO1364

115347123

putative HlyD family secretion protein [...

371

conserved gene; putative drug target function;

Phase 4: April 2009

3FPP

62.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02508
(show subtarget assignments)

1

cloned

No

lmo1847

16803887

hypothetical protein lmo1847 [Listeria m...

310

Known virulence-Invasion; PMID:12496198

Phase 3: June 2008

1PSZ

52.3%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP04129
(show subtarget assignments)

1

expressed

No

YPO0764

115346558

conserved hypothetical protein [Yersinia...

741

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

16.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04121
(show subtarget assignments)

1

cloned

No

YPO2725

115348408

conserved hypothetical protein [Yersinia...

921

virulence factor; putative drug target function;

Phase 4: April 2009

2P5Z

12.6%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02068
(show subtarget assignments)

1

crystallized

No

YPO3194

16123356

ahpC

putative alkyl hydroperoxide reductase s...

200

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1ZOF

59%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04291
(show subtarget assignments)

1

expressed

No

YPO3603

115349224

putative exported protein [Yersinia pest...

1177

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00996
(show subtarget assignments)

1

in_crystallization_trials

No

STM2310

16765637

menF

menaquinone-specific isochorismate synth...

431

Drug Target Function

Phase 2: March 2008

2EUA

78.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01848
(show subtarget assignments)

1

cloned

No

FTT1754

56708752

pta

phosphate acetyltransferase [Francisella...

698

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1TD9

19.9%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP04094
(show subtarget assignments)

1

expressed

No

YPO1966

218929080

astE

succinylglutamate desuccinylase [Yersini...

330

conserved gene; putative drug target function;

Phase 4: April 2009

1YW6

47.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00515
(show subtarget assignments)

1

cloned

No

YPO3922

16124053

hemophore HasA

205

Virulence Associated Factor

Phase 2: March 2008

1B2V

29.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP00512
(show subtarget assignments)

1

cloned

No

YPO2244

16122472

electron transport complex protein RnfC ...

620

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02459
(show subtarget assignments)

1

soluble

No

lmo2067

16804106

hypothetical protein lmo2067 [Listeria m...

325

Known virulence-Bile resistance; PMID:15664931

Phase 3: June 2008

2BJF

38.8%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP00217
(show subtarget assignments)

1

cloned

No

YPO2319

16122543

-

putative pepetidase

278

Virulence

Phase 1: October 2007

1AGJ

24.1%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02044
(show subtarget assignments)

1

expressed

No

FTT1132c

56708208

glpQ

glycerophosphoryl diester phosphodiester...

250

Drug Target

Phase 3: June 2008

1O1Z

28%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP04108
(show subtarget assignments)

1

expressed

No

YPO0507

115346316

conserved hypothetical protein [Yersinia...

782

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2P5Z

13.7%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02419
(show subtarget assignments)

1

purified

No

FTT1447c

56708489

manB

phosphomannomutase [Francisella tularens...

494

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

2F7L

25.7%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP00483
(show subtarget assignments)

1

expressed

No

YPO1316

16121598

putative iron/ascorbate oxidoreductase f...

355

Virulence Associated Factor

Phase 2: March 2008

3OOX

25.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01825
(show subtarget assignments)

1

cloned

No

STM2265

16765593

ada

O6-methylguanine-DNA methyltransferase/t...

353

Conserved; Drug target functions

Phase 3: June 2008

1SFE

37.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01819
(show subtarget assignments)

1

cloned

No

STM1145

16764501

csgC

putative autoagglutination protein [Salm...

108

Conserved; Drug target functions

Phase 3: June 2008

2Y2T

64.8%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01814
(show subtarget assignments)

1

expressed

No

STM1753

16765097

hnr

response regulator of RpoS [Salmonella t...

337

Conserved; Drug target functions

Phase 3: June 2008

3EOD

35.3%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02408
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1418

16121698

23S rRNA m(2)G2445 methyltransferase [Ye...

706

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3V8V

74.8%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP01923
(show subtarget assignments)

1

crystallized

No

STM1595

16764939

srfC

putative virulence protein [Salmonella t...

714

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01845
(show subtarget assignments)

1

cloned

No

STM0017

16763407

hypothetical protein STM0017 [Salmonella...

147

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP00466
(show subtarget assignments)

1

cloned

No

YPO1536

16121809

putative iron-siderophore transport syst...

359

Conserved Gene / Pathway

Phase 2: March 2008

3MWF

12.3%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02397
(show subtarget assignments)

1

purified

No

FTT1326

56708383

udp

uridine phosphorylase [Francisella tular...

267

Drug Target

Phase 3: June 2008

3O6V

43.1%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02025
(show subtarget assignments)

1

cloned

No

lmo0394

16802439

hypothetical protein lmo0394 [Listeria m...

227

Possible Vaccine Candidate; Presence of Protease Motifs

Phase 3: June 2008

2XIV

19.8%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP01748
(show subtarget assignments)

1

soluble

No

PSLT011

17233476

srgA

putative thiol-disulfide isomerase or th...

217

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

3L9V

85.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01732
(show subtarget assignments)

1

cloned

No

STM1243

16764598

cold shock-like protein [Salmonella typh...

70

Conserved; Drug target functions

Phase 3: June 2008

2L15

48.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01907
(show subtarget assignments)

1

in_crystallization_trials

No

STM1160

16764516

solA

N-methyltryptophan oxidase [Salmonella t...

372

Conserved; Drug target functions

Phase 3: June 2008

2UZZ

83.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02817
(show subtarget assignments)

1

cloned

No

lmo2185

16804224

hypothetical protein lmo2185 [Listeria m...

569

Known virulence-Intracellular Survival; Predicted virulence-Iron Scavenging Mech...

Phase 3: June 2008

2O6P

8.4%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP02013
(show subtarget assignments)

1

cloned

No

STM2395

16765721

pgtE

outer membrane protease [Salmonella typh...

312

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

2X55

69.9%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01843
(show subtarget assignments)

1

cloned

No

lmo0204

16802250

actA

actin-assembly inducing protein precurso...

639

Known virulence-Nucleation-promoting factor; Predicted virulence-Pathogenicity i...

Phase 3: June 2008

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP00442
(show subtarget assignments)

1

soluble

No

YPO2211

16122439

trpH

hypothetical protein YPO2211

299

Conserved Gene / Pathway

Phase 2: March 2008

2YB1

38.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02002
(show subtarget assignments)

1

in_pdb
4E4Y

No

FTT1014c

56708103

short chain dehydrogenase family protein...

241

Drug Target

Phase 3: June 2008

4E4Y

100%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02345
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1220

56708282

5-formyltetrahydroformate cycloligase fa...

182

Drug Target

Phase 3: June 2008

2JCB

28.6%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP01902
(show subtarget assignments)

1

soluble

No

STM0878

16764240

potG

putrescine transporter ATP-binding subun...

377

Conserved; Drug target functions

Phase 3: June 2008

1V43

38.7%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02352
(show subtarget assignments)

1

cloned

No

FTT1334c

56708390

hypothetical protein FTT1334c [Francisel...

169

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP01900
(show subtarget assignments)

1

purified

No

STM0570

16763947

apeE

outer membrane esterase [Salmonella typh...

656

Drug target functions

Phase 3: June 2008

3KVN

25.5%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01657
(show subtarget assignments)

1

cloned

No

YPO3061

16123238

dapX

lipoprotein [Yersinia pestis CO92]

352

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3TGO

56.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02774
(show subtarget assignments)

1

soluble

No

FTT0392c

56707541

hypothetical protein FTT0392c [Francisel...

109

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP01654
(show subtarget assignments)

1

expressed

No

STM1259

16764611

putative ABC-type transport system ATPas...

196

Conserved; Drug target functions

Phase 3: June 2008

1Z47

31.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01905
(show subtarget assignments)

1

cloned

No

STM1113

16764471

scsA

suppression of copper sensitivity protei...

120

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01898
(show subtarget assignments)

1

expressed

No

STM1669

16765012

invasin-like protein [Salmonella typhimu...

660

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Unclassified

Role category not yet assigned

IDP02308
(show subtarget assignments)

1

expressed

No

FTT1400c

56708448

hypothetical protein FTT1400c [Francisel...

128

Drug Target

Phase 3: June 2008

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02281
(show subtarget assignments)

1

cloned

No

YPO1305

16121587

psaC

outer membrane usher protein PsaC precur...

837

Conserved; CD; Involved in virulence; Drug target functions

Phase 3: June 2008

3RFZ

36.5%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02705
(show subtarget assignments)

1

cloned

No

lmo0202

16802248

hly

listeriolysin O precursor [Listeria mono...

529

Known virulence-Toxin; Predicted virulence-Pathogenicity islands; PMID:11901162

Phase 3: June 2008

3HVN

41%

Listeria monocytogenes

Unclassified

Role category not yet assigned

IDP02690
(show subtarget assignments)

1

cloned

No

FTT0954c

56708048

hypothetical protein FTT0954c [Francisel...

106

Drug Target

Phase 3: June 2008

1Y2I

36.8%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP02256
(show subtarget assignments)

1

purified

No

YPO1262

16121548

nucleoid-associated protein NdpA [Yersin...

334

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Unclassified

Role category not yet assigned

IDP04467
(show subtarget assignments)

1

soluble

No

YPO2174

218929273

putative nucleotide sugar dehydrogenase ...

448

virulence factor; putative drug target function;

Phase 4: April 2009

2Y0E

57.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP02663
(show subtarget assignments)

1

in_crystallization_trials

No

lmo2182

16804221

hypothetical protein lmo2182 [Listeria m...

259

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2GHI

30.9%

Listeria monocytogenes

Unclassified

Role category not yet assigned

Targets