Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP01212 (show subtarget assignments)	1	expressed	No	BA_3024	30257611		glycosyl transferase, group 2 family pro...	490	Essential Gene	Phase 2: March 2008	3E25	9.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01210 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2805	30257409		glycosyl hydrolase, family 25, putative ...	268	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	61.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01208 (show subtarget assignments)	1	expressed	No	BA_2638	30257255		glycosyl transferase, putative	387	Essential Gene	Phase 2: March 2008	2IYA	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01206 (show subtarget assignments)	1	purified	No	BA_2446	30257076		N-acetylmuramoyl-L-alanine amidase, fami...	245	Conserved Gene / Pathway	Phase 2: March 2008	1XOV	26.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01204 (show subtarget assignments)	1	crystallized	No	BA_2274	30256914		glycosyl transferase, group 2 family pro...	406	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01203 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2083	30256732		glycosyltransferase, MGT family	402	Conserved Gene / Pathway	Phase 2: March 2008	3IAA	29.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01200 (show subtarget assignments)	1	cloned	No	BA_1707	30255995		transglycosylase, SLT family	261	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01197 (show subtarget assignments)	0	work_stopped	No	BA_1389	81715334		D-alanine--poly(phosphoribitol) ligase s...	503	Conserved Gene / Pathway	Phase 2: March 2008	3DHV	99.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01195 (show subtarget assignments)	1	in_pdb 3SC6	No	BA_1231	30255180	rfbD	dTDP-4-dehydrorhamnose reductase	284	Drug Target Function	Phase 2: March 2008	3SC6	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01194 (show subtarget assignments)	1	in_pdb 4EGB	No	BA_1230	30255179	rfbB	dTDP-glucose 4,6-dehydratase	322	Conserved Gene / Pathway	Phase 2: March 2008	4EGB	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01938 (show subtarget assignments)	1	purified	No	Cj1423c	15792741		putative sugar-phosphate nucleotidyltran...	221	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	33.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01190 (show subtarget assignments)	1	cloned	No	BA_0872	30254622		N-acetylmuramoyl-L-alanine amidase, fami...	348	Drug Target Function	Phase 2: March 2008	3HMB	25.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01189 (show subtarget assignments)	1	expressed	No	BA_0505	30254033		glycosyl transferase, group 2 family pro...	528	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01187 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0485	30254015		prophage LambdaBa04, glycosyl hydrolase,...	265	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	71.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00620 (show subtarget assignments)	1	cloned	No	SACOL0937	57285812	dltC	D-alanine--poly(phosphoribitol) ligase s...	78	Conserved Gene / Pathway	Phase 2: March 2008	1DV5	41%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02521 (show subtarget assignments)	1	soluble	No	Cj1146c	15792471	waaV	lipooligosaccharide biosynthesis glycosy...	274	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	25.4%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01185 (show subtarget assignments)	1	cloned	No	BA_0280	30253775		glycosyl transferase, group 1 family pro...	443	Drug Target Function	Phase 2: March 2008	2JJM	13.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00307 (show subtarget assignments)	1	expressed	No	CBU_0142	29653500	lpxC	UDP-3-0-acyl N-acetylglucosamine deacety...	303	Drug Target Function	Phase 2: March 2008	2VES	65.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01179 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0048	81583548		Bifunctional protein glmU [Includes: UDP...	459	Drug Target Function	Phase 2: March 2008	1G95	51.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00134 (show subtarget assignments)	1	purified	No	VC_2250	9656811	VC2250	Vibrio cholerae O1 biovar eltor str. N16...	351	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3EH0	63%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02378 (show subtarget assignments)	1	cloned	No	CBU_1675	29542234	kdsA	2-dehydro-3-deoxyphosphooctonate aldolas...	280	Conserved; Drug target functions	Phase 3: June 2008	3T4C	62.5%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01151 (show subtarget assignments)	0	work_stopped	No	BA_5433	30259901		UDP-N-acetylglucosamine 2-epimerase	371	Conserved Gene / Pathway	Phase 2: March 2008	3BEO	99.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02173 (show subtarget assignments)	1	expressed	No	Cj1136	15792461		putative galactosyltransferase [Campylob...	390	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...	Phase 3: June 2008	3L7I	20.8%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04178 (show subtarget assignments)	1	expressed	No	VC2718	15642712		bioH protein [Vibrio cholerae O1 biovar ...	268	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1M33	49.3%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00580 (show subtarget assignments)	1	purified	No	YPO0059	16120412	kbl	2-amino-3-ketobutyrate coenzyme A ligase...	403	Conserved Gene / Pathway	Phase 2: March 2008	1FC4	82.9%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04033 (show subtarget assignments)	1	soluble	No	VC1950	15641952		biotin sulfoxide reductase [Vibrio chole...	815	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1E18	48.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04048 (show subtarget assignments)	1	in_crystallization_trials	No	VC1112	15641125		biotin synthase [Vibrio cholerae O1 biov...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1R30	69.7%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01059 (show subtarget assignments)	1	purified	No	STM3509	16766797	bioH	carboxylesterase BioH	256	Drug Target Function	Phase 2: March 2008	1M33	79.3%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02046 (show subtarget assignments)	1	soluble	No	CBU_1007	29541589	bioB	biotin synthase [Coxiella burnetii RSA 4...	321	Conserved; Drug target functions	Phase 3: June 2008	1R30	55.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00230 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3444	16123592	-	putative acetyltransferase	167	Virulence	Phase 1: October 2007	2GE3	18%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00527 (show subtarget assignments)	1	purified	No	YPO0129	16120472	bioH	putative biotin biosynthesis protein	258	Drug Target Function	Phase 2: March 2008	1M33	63.6%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00937 (show subtarget assignments)	1	cloned	No	STM0795	16764158	bioF	8-amino-7-oxononanoate synthase	385	Conserved Gene / Pathway	Phase 2: March 2008	1BS0	80%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP00936 (show subtarget assignments)	1	soluble	No	STM0793	16764156	bioA	adenosylmethionine--8-amino-7-oxononanoa...	429	Conserved Gene / Pathway	Phase 2: March 2008	1MLY	86.2%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04719 (show subtarget assignments)	1	expressed	No	YPO1151	218928315	bioB	biotin synthase [Yersinia pestis CO92]	345	conserved gene; putative drug target function;	Phase 4: April 2009	1R30	83.8%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01797 (show subtarget assignments)	1	cloned	No	CBU_1008	29541590	bioA	adenosylmethionine-8-amino-7-oxononanoat...	442	Conserved; Drug target functions	Phase 3: June 2008	3DOD	35.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02725 (show subtarget assignments)	1	crystallized	No	GBAA4341	47529638	bioA	adenosylmethionine--8-amino-7-oxononanoa...	462	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DOD	57.1%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04687 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4340	47529637	bioD	dithiobiotin synthetase [Bacillus anthra...	242	putative drug target function;	Phase 4: April 2009	1A82	26.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02629 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1006	29541588	bioF	8-amino-7-oxononanoate synthase [Coxiell...	384	Conserved; Drug target functions	Phase 3: June 2008	1BS0	37.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02289 (show subtarget assignments)	1	in_pdb 3OF5	No	FTT0934c	56708031	bioD	dethiobiotin synthetase [Francisella tul...	225	Conserved; Drug target functions	Phase 3: June 2008	3OF5	100%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04426 (show subtarget assignments)	1	expressed	No	GBAA4339	47529636	bioF	8-amino-7-oxononanoate synthase [Bacillu...	395	putative drug target function;	Phase 4: April 2009	3A2B	33.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP02559 (show subtarget assignments)	1	cloned	No	YPO3325	16123478	dmsA	anaerobic dimethyl sulfoxide reductase c...	816	Conserved; CD; Drug target functions	Phase 3: June 2008	1E60	28.7%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01958 (show subtarget assignments)	1	expressed	No	FTT0937c	56708034	bioB	biotin synthase [Francisella tularensis ...	313	Drug Target	Phase 3: June 2008	1R30	49.2%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP04281 (show subtarget assignments)	1	cloned	No	YPO1150	115346925	bioA	adenosylmethionine-8-amino-7-oxononanoat...	422	conserved gene; putative drug target function;	Phase 4: April 2009	1MLY	73.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01953 (show subtarget assignments)	1	soluble	No	FTT0936c	56708033	bioF	8-amino-7-oxononanoate synthase [Francis...	375	Conserved; Drug target functions	Phase 3: June 2008	1BS0	32%	Francisella tularensis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01126 (show subtarget assignments)	1	cloned	No	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00587 (show subtarget assignments)	1	cloned	No	YPO1507	16121780	mglB	galactose-binding protein	335	Virulence Associated Factor	Phase 2: March 2008	1GCA	80.9%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01123 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4267	30258769	ptsI	phosphoenolpyruvate-protein phosphotrans...	570	Conserved Gene / Pathway	Phase 2: March 2008	2HRO	65.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01100 (show subtarget assignments)	1	in_pdb 3K1S	No	BA_5442	30259910	celC-2	PTS system, cellobiose-specific IIA comp...	107	Conserved Gene / Pathway	Phase 2: March 2008	3K1S	99.1%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01052 (show subtarget assignments)	1	expressed	No	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04377 (show subtarget assignments)	1	soluble	No	CPF_2652	110798678		putative maltose/maltodextrin ABC transp...	408	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1URG	38.7%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00231 (show subtarget assignments)	1	soluble	No	YPO3479	16123625	-	putative protease	331	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04242 (show subtarget assignments)	1	cloned	No	CPF_1113	110798641		sugar ABC transporter, sugar-binding pro...	419	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3QUF	22.9%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02243 (show subtarget assignments)	1	cloned	No	YPO0834	16121142	manX	putative PTS transport protein [Yersinia...	165	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3EYE	41.8%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00220 (show subtarget assignments)	1	purified	No	YPO2855	16123048	-	putative protease	464	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00505 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1298	16121580	fruB	fructose-specific PTS IIA/HPr components...	377	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	17%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00104 (show subtarget assignments)	1	purified	No	NT01SF3305	30042319	srlB	PTS system, glucitol/sorbitol-specific e...	123	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2F9H	25.2%	Shigella flexneri	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01818 (show subtarget assignments)	1	soluble	No	GBAA5444	47530758	celA-2	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	42%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00892 (show subtarget assignments)	0	work_stopped	No	STM3881	16767165	rbsD	high-affinity D-ribose transport protein...	139	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00885 (show subtarget assignments)	1	purified	No	STM2206	16765536	fruF	fructose-specific PTS IIA/HPr components...	376	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	17.3%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01795 (show subtarget assignments)	1	expressed	No	GBAA0792	47526077	celA-1	PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41.6%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02726 (show subtarget assignments)	1	cloned	No	GBAA4229	47529522		maltosaccharide ABC transporter, maltosa...	419	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZYK	41.5%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00193 (show subtarget assignments)	1	expressed	No	YPO0966	16121269	-	putative kinase	765	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00458 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2680	16122885	celC	N,N'-diacetylchitobiose-specific PTS sys...	115	Conserved Gene / Pathway	Phase 2: March 2008	1WCR	67%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00186 (show subtarget assignments)	1	soluble	No	YPO0695	16121016	-	putative membrane protein	140	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02650 (show subtarget assignments)	1	expressed	No	YPO3962	16124090		sugar-binding transport protein [Yersini...	314	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	34.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00818 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2148	57286362		PTS system, mannitol-specific IIA compon...	144	Drug Target Function	Phase 2: March 2008	1A3A	34.7%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01614 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2581	16122794		putative sugar-binding periplasmic prote...	309	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	29.5%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01514 (show subtarget assignments)	1	purified	No	VCA0518	15601278		fructose-specific PTS IIA/HPr components...	400	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	11.5%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01508 (show subtarget assignments)	1	expressed	No	VCA0127	15600898		ribose ABC transporter protein	156	Conserved Gene / Pathway	Phase 2: March 2008	3DSA	48.1%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01504 (show subtarget assignments)	1	expressed	No	VCA1028	15601781	lamB	maltoporin	416	Conserved Gene / Pathway	Phase 2: March 2008	1AF6	32.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01501 (show subtarget assignments)	1	expressed	No	VCA0946	15601699		maltose/maltodextrin transporter ATP-bin...	373	Conserved Gene / Pathway	Phase 2: March 2008	1Q12	67.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01500 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0945	15601698	malE	maltose ABC transporter periplasmic prot...	406	Conserved Gene / Pathway	Phase 2: March 2008	3JYR	65%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00760 (show subtarget assignments)	1	soluble	No	SACOL0192	57285394		maltose ABC transporter, ATP-binding pro...	365	Drug Target Function	Phase 2: March 2008	2D62	53.5%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01498 (show subtarget assignments)	1	expressed	No	VCA0862	15601617		long-chain fatty acid transport protein ...	412	Conserved Gene / Pathway	Phase 2: March 2008	1T16	39.2%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01481 (show subtarget assignments)	1	expressed	No	VCA0130	15600901		D-ribose transporter subunit RbsB	294	Conserved Gene / Pathway	Phase 2: March 2008	1DBP	65.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02601 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA2462	47527752		PTS system, cellobiose-specific IIB comp...	101	Conserved; Essential; Drug target functions	Phase 3: June 2008	2L2Q	29.7%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01852 (show subtarget assignments)	1	cloned	No	GBAA5449	47530763	celA-3	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00719 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1457	57284566		PTS system, IIA component	166	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	41%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00079 (show subtarget assignments)	1	in_pdb 3DSA 3E7N	No	NT01ST4845	16422456	rbsD	D-ribose high-affinity transport system ...	139	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3DSA	100%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01408 (show subtarget assignments)	1	purified	No	VC0965	15640981		phosphoenolpyruvate-protein phosphotrans...	573	Conserved Gene / Pathway	Phase 2: March 2008	2KX9	74.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01964 (show subtarget assignments)	1	in_pdb 3KWO	No	Cj1534c	15792842		bacterioferritin [Campylobacter jejuni s...	149	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3KWO	100%	Campylobacter jejuni	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00703 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0250	57286711		PTS system, IIA component	263	Conserved Gene / Pathway	Phase 2: March 2008	1AX3	21.7%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02552 (show subtarget assignments)	1	expressed	No	CBU_0743	29541343	ptsH	phosphocarrier protein HPr [Coxiella bur...	89	Conserved; Drug target functions	Phase 3: June 2008	3LE1	46.1%	Coxiella burnetii	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01317 (show subtarget assignments)	1	soluble	No	VC0966	15640982		phosphocarrier protein HPr	85	Conserved Gene / Pathway	Phase 2: March 2008	1GGR	75.3%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02276 (show subtarget assignments)	1	expressed	No	YPO0860	16121168		sugar-binding periplasmic protein [Yersi...	333	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	26.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01307 (show subtarget assignments)	1	soluble	No	VC1283	15641296		PTS system, cellobiose-specific IIA comp...	111	Conserved Gene / Pathway	Phase 2: March 2008	1WCR	45.9%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01306 (show subtarget assignments)	1	purified	No	VC1281	15641294		PTS system, cellobiose-specific IIB comp...	101	Conserved Gene / Pathway	Phase 2: March 2008	2L2Q	40.6%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01237 (show subtarget assignments)	1	purified	No	BA_5563	46396830		Glucose-specific phosphotransferase enzy...	165	Drug Target Function	Phase 2: March 2008	1GGR	46.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04249 (show subtarget assignments)	1	expressed	No	CPF_1548	110800969		putative galactoside ABC transporter, ga...	354	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1GLG	50.6%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01227 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4268	30258770	ptsH-1	phosphocarrier protein HPr	87	Conserved Gene / Pathway	Phase 2: March 2008	1Y4Y	72.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02197 (show subtarget assignments)	1	cloned	No	YPO0405	16120739		putative phosphoenolpyruvate-protein pho...	852	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2KX9	24.6%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02215 (show subtarget assignments)	1	cloned	No	Cj0077c	15791467	cdtC	cytolethal distending toxin [Campylobact...	189	Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01131 (show subtarget assignments)	1	in_pdb 3IHS	Yes	BA_5381	30259854	ptsH-2	phosphocarrier protein HPr	82	Conserved Gene / Pathway	Phase 2: March 2008	3IHS	100%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01129 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5296	30259774		ferritin	168	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	48.2%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01108 (show subtarget assignments)	1	in_pdb	No	BA_3860	30258377		copper-ion-binding protein	68	Conserved Gene / Pathway	Phase 2: March 2008	2L3M	100%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01104 (show subtarget assignments)	1	soluble	No	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04509 (show subtarget assignments)	1	selected	No	CPF_0440	110800446		iron compound ABC transporter, iron comp...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PT1	37.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP01212
(show subtarget assignments)

1

expressed

No

BA_3024

30257611

glycosyl transferase, group 2 family pro...

490

Essential Gene

Phase 2: March 2008

3E25

9.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01210
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2805

30257409

glycosyl hydrolase, family 25, putative ...

268

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

61.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01208
(show subtarget assignments)

1

expressed

No

BA_2638

30257255

glycosyl transferase, putative

387

Essential Gene

Phase 2: March 2008

2IYA

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01206
(show subtarget assignments)

1

purified

No

BA_2446

30257076

N-acetylmuramoyl-L-alanine amidase, fami...

245

Conserved Gene / Pathway

Phase 2: March 2008

1XOV

26.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01204
(show subtarget assignments)

1

crystallized

No

BA_2274

30256914

glycosyl transferase, group 2 family pro...

406

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01203
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2083

30256732

glycosyltransferase, MGT family

402

Conserved Gene / Pathway

Phase 2: March 2008

3IAA

29.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01200
(show subtarget assignments)

1

cloned

No

BA_1707

30255995

transglycosylase, SLT family

261

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01197
(show subtarget assignments)

0

work_stopped

No

BA_1389

81715334

D-alanine--poly(phosphoribitol) ligase s...

503

Conserved Gene / Pathway

Phase 2: March 2008

3DHV

99.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01195
(show subtarget assignments)

1

in_pdb
3SC6

No

BA_1231

30255180

rfbD

dTDP-4-dehydrorhamnose reductase

284

Drug Target Function

Phase 2: March 2008

3SC6

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01194
(show subtarget assignments)

1

in_pdb
4EGB

No

BA_1230

30255179

rfbB

dTDP-glucose 4,6-dehydratase

322

Conserved Gene / Pathway

Phase 2: March 2008

4EGB

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01938
(show subtarget assignments)

1

purified

No

Cj1423c

15792741

putative sugar-phosphate nucleotidyltran...

221

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

33.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01190
(show subtarget assignments)

1

cloned

No

BA_0872

30254622

N-acetylmuramoyl-L-alanine amidase, fami...

348

Drug Target Function

Phase 2: March 2008

3HMB

25.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01189
(show subtarget assignments)

1

expressed

No

BA_0505

30254033

glycosyl transferase, group 2 family pro...

528

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01187
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0485

30254015

prophage LambdaBa04, glycosyl hydrolase,...

265

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

71.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00620
(show subtarget assignments)

1

cloned

No

SACOL0937

57285812

dltC

D-alanine--poly(phosphoribitol) ligase s...

78

Conserved Gene / Pathway

Phase 2: March 2008

1DV5

41%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02521
(show subtarget assignments)

1

soluble

No

Cj1146c

15792471

waaV

lipooligosaccharide biosynthesis glycosy...

274

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

25.4%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01185
(show subtarget assignments)

1

cloned

No

BA_0280

30253775

glycosyl transferase, group 1 family pro...

443

Drug Target Function

Phase 2: March 2008

2JJM

13.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00307
(show subtarget assignments)

1

expressed

No

CBU_0142

29653500

lpxC

UDP-3-0-acyl N-acetylglucosamine deacety...

303

Drug Target Function

Phase 2: March 2008

2VES

65.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01179
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0048

81583548

Bifunctional protein glmU [Includes: UDP...

459

Drug Target Function

Phase 2: March 2008

1G95

51.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00134
(show subtarget assignments)

1

purified

No

VC_2250

9656811

VC2250

Vibrio cholerae O1 biovar eltor str. N16...

351

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3EH0

63%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02378
(show subtarget assignments)

1

cloned

No

CBU_1675

29542234

kdsA

2-dehydro-3-deoxyphosphooctonate aldolas...

280

Conserved; Drug target functions

Phase 3: June 2008

3T4C

62.5%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01151
(show subtarget assignments)

0

work_stopped

No

BA_5433

30259901

UDP-N-acetylglucosamine 2-epimerase

371

Conserved Gene / Pathway

Phase 2: March 2008

3BEO

99.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02173
(show subtarget assignments)

1

expressed

No

Cj1136

15792461

putative galactosyltransferase [Campylob...

390

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...

Phase 3: June 2008

3L7I

20.8%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04178
(show subtarget assignments)

1

expressed

No

VC2718

15642712

bioH protein [Vibrio cholerae O1 biovar ...

268

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1M33

49.3%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00580
(show subtarget assignments)

1

purified

No

YPO0059

16120412

kbl

2-amino-3-ketobutyrate coenzyme A ligase...

403

Conserved Gene / Pathway

Phase 2: March 2008

1FC4

82.9%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04033
(show subtarget assignments)

1

soluble

No

VC1950

15641952

biotin sulfoxide reductase [Vibrio chole...

815

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1E18

48.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04048
(show subtarget assignments)

1

in_crystallization_trials

No

VC1112

15641125

biotin synthase [Vibrio cholerae O1 biov...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1R30

69.7%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01059
(show subtarget assignments)

1

purified

No

STM3509

16766797

bioH

carboxylesterase BioH

256

Drug Target Function

Phase 2: March 2008

1M33

79.3%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02046
(show subtarget assignments)

1

soluble

No

CBU_1007

29541589

bioB

biotin synthase [Coxiella burnetii RSA 4...

321

Conserved; Drug target functions

Phase 3: June 2008

1R30

55.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00230
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3444

16123592

-

putative acetyltransferase

167

Virulence

Phase 1: October 2007

2GE3

18%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00527
(show subtarget assignments)

1

purified

No

YPO0129

16120472

bioH

putative biotin biosynthesis protein

258

Drug Target Function

Phase 2: March 2008

1M33

63.6%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00937
(show subtarget assignments)

1

cloned

No

STM0795

16764158

bioF

8-amino-7-oxononanoate synthase

385

Conserved Gene / Pathway

Phase 2: March 2008

1BS0

80%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP00936
(show subtarget assignments)

1

soluble

No

STM0793

16764156

bioA

adenosylmethionine--8-amino-7-oxononanoa...

429

Conserved Gene / Pathway

Phase 2: March 2008

1MLY

86.2%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04719
(show subtarget assignments)

1

expressed

No

YPO1151

218928315

bioB

biotin synthase [Yersinia pestis CO92]

345

conserved gene; putative drug target function;

Phase 4: April 2009

1R30

83.8%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01797
(show subtarget assignments)

1

cloned

No

CBU_1008

29541590

bioA

adenosylmethionine-8-amino-7-oxononanoat...

442

Conserved; Drug target functions

Phase 3: June 2008

3DOD

35.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02725
(show subtarget assignments)

1

crystallized

No

GBAA4341

47529638

bioA

adenosylmethionine--8-amino-7-oxononanoa...

462

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DOD

57.1%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04687
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4340

47529637

bioD

dithiobiotin synthetase [Bacillus anthra...

242

putative drug target function;

Phase 4: April 2009

1A82

26.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02629
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1006

29541588

bioF

8-amino-7-oxononanoate synthase [Coxiell...

384

Conserved; Drug target functions

Phase 3: June 2008

1BS0

37.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02289
(show subtarget assignments)

1

in_pdb
3OF5

No

FTT0934c

56708031

bioD

dethiobiotin synthetase [Francisella tul...

225

Conserved; Drug target functions

Phase 3: June 2008

3OF5

100%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04426
(show subtarget assignments)

1

expressed

No

GBAA4339

47529636

bioF

8-amino-7-oxononanoate synthase [Bacillu...

395

putative drug target function;

Phase 4: April 2009

3A2B

33.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP02559
(show subtarget assignments)

1

cloned

No

YPO3325

16123478

dmsA

anaerobic dimethyl sulfoxide reductase c...

816

Conserved; CD; Drug target functions

Phase 3: June 2008

1E60

28.7%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01958
(show subtarget assignments)

1

expressed

No

FTT0937c

56708034

bioB

biotin synthase [Francisella tularensis ...

313

Drug Target

Phase 3: June 2008

1R30

49.2%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP04281
(show subtarget assignments)

1

cloned

No

YPO1150

115346925

bioA

adenosylmethionine-8-amino-7-oxononanoat...

422

conserved gene; putative drug target function;

Phase 4: April 2009

1MLY

73.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01953
(show subtarget assignments)

1

soluble

No

FTT0936c

56708033

bioF

8-amino-7-oxononanoate synthase [Francis...

375

Conserved; Drug target functions

Phase 3: June 2008

1BS0

32%

Francisella tularensis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01126
(show subtarget assignments)

1

cloned

No

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00587
(show subtarget assignments)

1

cloned

No

YPO1507

16121780

mglB

galactose-binding protein

335

Virulence Associated Factor

Phase 2: March 2008

1GCA

80.9%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01123
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4267

30258769

ptsI

phosphoenolpyruvate-protein phosphotrans...

570

Conserved Gene / Pathway

Phase 2: March 2008

2HRO

65.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01100
(show subtarget assignments)

1

in_pdb
3K1S

No

BA_5442

30259910

celC-2

PTS system, cellobiose-specific IIA comp...

107

Conserved Gene / Pathway

Phase 2: March 2008

3K1S

99.1%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01052
(show subtarget assignments)

1

expressed

No

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04377
(show subtarget assignments)

1

soluble

No

CPF_2652

110798678

putative maltose/maltodextrin ABC transp...

408

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1URG

38.7%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00231
(show subtarget assignments)

1

soluble

No

YPO3479

16123625

-

putative protease

331

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04242
(show subtarget assignments)

1

cloned

No

CPF_1113

110798641

sugar ABC transporter, sugar-binding pro...

419

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3QUF

22.9%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02243
(show subtarget assignments)

1

cloned

No

YPO0834

16121142

manX

putative PTS transport protein [Yersinia...

165

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3EYE

41.8%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00220
(show subtarget assignments)

1

purified

No

YPO2855

16123048

-

putative protease

464

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00505
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1298

16121580

fruB

fructose-specific PTS IIA/HPr components...

377

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

17%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00104
(show subtarget assignments)

1

purified

No

NT01SF3305

30042319

srlB

PTS system, glucitol/sorbitol-specific e...

123

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2F9H

25.2%

Shigella flexneri

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01818
(show subtarget assignments)

1

soluble

No

GBAA5444

47530758

celA-2

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

42%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00892
(show subtarget assignments)

0

work_stopped

No

STM3881

16767165

rbsD

high-affinity D-ribose transport protein...

139

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00885
(show subtarget assignments)

1

purified

No

STM2206

16765536

fruF

fructose-specific PTS IIA/HPr components...

376

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

17.3%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01795
(show subtarget assignments)

1

expressed

No

GBAA0792

47526077

celA-1

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41.6%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02726
(show subtarget assignments)

1

cloned

No

GBAA4229

47529522

maltosaccharide ABC transporter, maltosa...

419

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZYK

41.5%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00193
(show subtarget assignments)

1

expressed

No

YPO0966

16121269

-

putative kinase

765

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00458
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2680

16122885

celC

N,N'-diacetylchitobiose-specific PTS sys...

115

Conserved Gene / Pathway

Phase 2: March 2008

1WCR

67%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00186
(show subtarget assignments)

1

soluble

No

YPO0695

16121016

-

putative membrane protein

140

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02650
(show subtarget assignments)

1

expressed

No

YPO3962

16124090

sugar-binding transport protein [Yersini...

314

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

34.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00818
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2148

57286362

PTS system, mannitol-specific IIA compon...

144

Drug Target Function

Phase 2: March 2008

1A3A

34.7%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01614
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2581

16122794

putative sugar-binding periplasmic prote...

309

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

29.5%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01514
(show subtarget assignments)

1

purified

No

VCA0518

15601278

fructose-specific PTS IIA/HPr components...

400

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

11.5%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01508
(show subtarget assignments)

1

expressed

No

VCA0127

15600898

ribose ABC transporter protein

156

Conserved Gene / Pathway

Phase 2: March 2008

3DSA

48.1%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01504
(show subtarget assignments)

1

expressed

No

VCA1028

15601781

lamB

maltoporin

416

Conserved Gene / Pathway

Phase 2: March 2008

1AF6

32.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01501
(show subtarget assignments)

1

expressed

No

VCA0946

15601699

maltose/maltodextrin transporter ATP-bin...

373

Conserved Gene / Pathway

Phase 2: March 2008

1Q12

67.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01500
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0945

15601698

malE

maltose ABC transporter periplasmic prot...

406

Conserved Gene / Pathway

Phase 2: March 2008

3JYR

65%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00760
(show subtarget assignments)

1

soluble

No

SACOL0192

57285394

maltose ABC transporter, ATP-binding pro...

365

Drug Target Function

Phase 2: March 2008

2D62

53.5%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01498
(show subtarget assignments)

1

expressed

No

VCA0862

15601617

long-chain fatty acid transport protein ...

412

Conserved Gene / Pathway

Phase 2: March 2008

1T16

39.2%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01481
(show subtarget assignments)

1

expressed

No

VCA0130

15600901

D-ribose transporter subunit RbsB

294

Conserved Gene / Pathway

Phase 2: March 2008

1DBP

65.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02601
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA2462

47527752

PTS system, cellobiose-specific IIB comp...

101

Conserved; Essential; Drug target functions

Phase 3: June 2008

2L2Q

29.7%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01852
(show subtarget assignments)

1

cloned

No

GBAA5449

47530763

celA-3

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00719
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1457

57284566

PTS system, IIA component

166

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

41%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00079
(show subtarget assignments)

1

in_pdb
3DSA
3E7N

No

NT01ST4845

16422456

rbsD

D-ribose high-affinity transport system ...

139

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3DSA

100%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01408
(show subtarget assignments)

1

purified

No

VC0965

15640981

phosphoenolpyruvate-protein phosphotrans...

573

Conserved Gene / Pathway

Phase 2: March 2008

2KX9

74.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01964
(show subtarget assignments)

1

in_pdb
3KWO

No

Cj1534c

15792842

bacterioferritin [Campylobacter jejuni s...

149

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3KWO

100%

Campylobacter jejuni

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00703
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0250

57286711

PTS system, IIA component

263

Conserved Gene / Pathway

Phase 2: March 2008

1AX3

21.7%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02552
(show subtarget assignments)

1

expressed

No

CBU_0743

29541343

ptsH

phosphocarrier protein HPr [Coxiella bur...

89

Conserved; Drug target functions

Phase 3: June 2008

3LE1

46.1%

Coxiella burnetii

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01317
(show subtarget assignments)

1

soluble

No

VC0966

15640982

phosphocarrier protein HPr

85

Conserved Gene / Pathway

Phase 2: March 2008

1GGR

75.3%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02276
(show subtarget assignments)

1

expressed

No

YPO0860

16121168

sugar-binding periplasmic protein [Yersi...

333

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

26.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01307
(show subtarget assignments)

1

soluble

No

VC1283

15641296

PTS system, cellobiose-specific IIA comp...

111

Conserved Gene / Pathway

Phase 2: March 2008

1WCR

45.9%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01306
(show subtarget assignments)

1

purified

No

VC1281

15641294

PTS system, cellobiose-specific IIB comp...

101

Conserved Gene / Pathway

Phase 2: March 2008

2L2Q

40.6%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01237
(show subtarget assignments)

1

purified

No

BA_5563

46396830

Glucose-specific phosphotransferase enzy...

165

Drug Target Function

Phase 2: March 2008

1GGR

46.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04249
(show subtarget assignments)

1

expressed

No

CPF_1548

110800969

putative galactoside ABC transporter, ga...

354

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1GLG

50.6%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01227
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4268

30258770

ptsH-1

phosphocarrier protein HPr

87

Conserved Gene / Pathway

Phase 2: March 2008

1Y4Y

72.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02197
(show subtarget assignments)

1

cloned

No

YPO0405

16120739

putative phosphoenolpyruvate-protein pho...

852

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2KX9

24.6%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02215
(show subtarget assignments)

1

cloned

No

Cj0077c

15791467

cdtC

cytolethal distending toxin [Campylobact...

189

Known Predicted virulence-cytolethal distending toxin; Predicted virulence-Toxin...

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01131
(show subtarget assignments)

1

in_pdb
3IHS

Yes

BA_5381

30259854

ptsH-2

phosphocarrier protein HPr

82

Conserved Gene / Pathway

Phase 2: March 2008

3IHS

100%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01129
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5296

30259774

ferritin

168

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

48.2%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01108
(show subtarget assignments)

1

in_pdb

No

BA_3860

30258377

copper-ion-binding protein

68

Conserved Gene / Pathway

Phase 2: March 2008

2L3M

100%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01104
(show subtarget assignments)

1

soluble

No

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04509
(show subtarget assignments)

1

selected

No

CPF_0440

110800446

iron compound ABC transporter, iron comp...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PT1

37.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

Targets