Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05228 (show subtarget assignments)	1	soluble	No	lmo0971	16803011	dltD	DltD protein for D-alanine esterificatio...	380	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3BMA	31.6%	Listeria monocytogenes	Cell envelope: Other

IDP05652 (show subtarget assignments)	1	cloned	No	lmo0129	16802177	-	hypothetical protein lmo0129 [Listeria m...	246	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3NE8	27.2%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05253 (show subtarget assignments)	1	cloned	No	CD0259	126697831		putative flagellar protein [Clostridium ...	107	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05010 (show subtarget assignments)	1	soluble	No	BA_4934	30259430		putative lipoprotein [Bacillus anthracis...	144	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05544 (show subtarget assignments)	1	purified	No	Cj1409	6968828	acpS	putative Ni/Fe-hydrogenase small subunit...	115	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3HYK	39.5%	Campylobacter jejuni	Fatty acid and phospholipid metabolism: Biosynthesis

IDP05232 (show subtarget assignments)	1	in_pdb 3TX1	No	lmo1420	16803460	-	hypothetical protein lmo1420 [Listeria m...	298	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3TX1	100%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05240 (show subtarget assignments)	1	expressed	No	CD0233	126697804		hypothetical protein CD0233 [Clostridium...	130	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AJ7	33.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04339 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0115	49183149		50S ribosomal protein L22 [Bacillus anth...	113	Proposed to be essential proteins	Phase 4: April 2009	1BXE	59.3%	Bacillus anthracis

IDP05231 (show subtarget assignments)	1	purified	No	lmo1388	16803428	tcsA	CD4+ T cell-stimulating antigen, lipopro...	346	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	39.9%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP04336 (show subtarget assignments)	8	in_crystallization_trials	No	CAC05790	12329059	ospC1	OspC1, secreted by the Mxi-Spa secretion...	470	Shigella effector protein	Community Requests			Shigella flexneri

IDP05466 (show subtarget assignments)	1	soluble	No	BA_1948	30256606		putative lipoprotein [Bacillus anthracis...	148	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05233 (show subtarget assignments)	1	cloned	No	lmo1455	16803495	dnaG	DNA primase [Listeria monocytogenes EGD-...	626	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2AU3	21.7%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05465 (show subtarget assignments)	1	cloned	No	BA_1580	30255880		conserved hypothetical protein [Bacillus...	159	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05239 (show subtarget assignments)	1	cloned	No	lmo1896	16803935	ansB	asparaginyl-tRNA synthetase [Listeria mo...	430	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	45.3%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05235 (show subtarget assignments)	1	cloned	No	lmo1532	16803572	ruvB	Holliday junction DNA helicase B [Lister...	335	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3PFI	55.2%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05234 (show subtarget assignments)	1	cloned	No	lmo1519	16803559	aspS	aspartyl-tRNA synthetase [Listeria monoc...	591	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1EQR	52.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05237 (show subtarget assignments)	1	soluble	No	lmo1653	16803693	-	putative cellsurface protein [Listeria m...	201	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP05236 (show subtarget assignments)	1	crystallized	No	lmo1533	16803573	ruvA	hypothetical protein lmo1533 [Listeria m...	201	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	34.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05723 (show subtarget assignments)	1	expressed	No	BA_3001	30257589		alkaline phosphatase [Bacillus anthracis...	557	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3A52	25.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP05009 (show subtarget assignments)	1	soluble	No	BA_4237	30258740		putative lipoprotein [Bacillus anthracis...	253	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05724 (show subtarget assignments)	1	soluble	No	BA_3370	30257913		ribonuclease [Bacillus anthracis str. Am...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Transcription: Degradation of RNA

IDP04335 (show subtarget assignments)	1	cloned	No	STM1543_1_428	16764888		putative transport protein [Salmonella t...	428	Salmonella essential protein	Phase 4: April 2009	1PW4	23.4%	Salmonella enterica

IDP05244 (show subtarget assignments)	1	soluble	No	lmo2203	16804242	-	hypothetical protein lmo2203 [Listeria m...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M9S	22.6%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05243 (show subtarget assignments)	1	crystallized	No	lmo2198	16804237	trpS	tryptophanyl-tRNA synthetase [Listeria m...	331	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3PRH	72.2%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP04060 (show subtarget assignments)	8	selected	No	CAC05813	12329082	mxiI	MxiI, component of the Mxi-Spa secretion...	97	Shigella effector protein	Community Requests			Shigella flexneri

IDP05241 (show subtarget assignments)	1	cloned	No	lmo1955	16803994	-	hypothetical protein lmo1955 [Listeria m...	297	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1A0P	43.8%	Listeria monocytogenes	Mobile and extrachromosomal element functions: Prophage functions

IDP05248 (show subtarget assignments)	1	expressed	No	lmo2691	16804728	-	autolysin [Listeria monocytogenes EGD-e]...	590	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	16.1%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05245 (show subtarget assignments)	1	soluble	No	lmo2349	16804387	-	hypothetical protein lmo2349 [Listeria m...	269	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2O1M	71%	Listeria monocytogenes	Transport and binding proteins: Unknown substrate

IDP91154 (show subtarget assignments)	8	in_pdb 3QFG	Yes	SAOUHSC_00808	88194568		hypothetical protein SAOUHSC_00808 [Stap...	242	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3QFG	93.4%	Staphylococcus aureus

IDP05543 (show subtarget assignments)	1	cloned	No	CD2628	126700242		hypothetical protein CD2628 [Clostridium...	642	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05247 (show subtarget assignments)	1	cloned	No	lmo2636	16804674	-	hypothetical protein lmo2636 [Listeria m...	360	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VRM	29.4%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05252 (show subtarget assignments)	1	soluble	No	lmo2854	16804891	-	hypothetical protein lmo2854 [Listeria m...	267	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Cell envelope: Other

IDP05246 (show subtarget assignments)	1	soluble	No	lmo2439	16804477	-	hypothetical protein lmo2439 [Listeria m...	113	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K5Q	33.6%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP91163 (show subtarget assignments)	8	cloned	No	VC1507	15641516		phospho-2-dehydro-3-deoxyheptonate aldol...	395	potential drug target / Shikimate pathway enzyme	Community Requests	1GG1	48.9%	Vibrio cholerae

IDP05046 (show subtarget assignments)	1	expressed	No	BA_3529	30258064		hypothetical protein BA_3529 [Bacillus a...	117	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP04584 (show subtarget assignments)	1	purified	No	BAS0112	49183146		50S ribosomal protein L23 [Bacillus anth...	96	Proposed to be essential proteins	Phase 4: April 2009	1N88	43.8%	Bacillus anthracis

IDP04637 (show subtarget assignments)	1	cloned	No	FTT0371c	56707522	folC	FolC bifunctional protein [Francisella t...	393	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1W78	29.8%	Francisella tularensis

IDP04067 (show subtarget assignments)	1	purified	No	BAS4417	49187412		thioredoxin [Bacillus anthracis str. Ste...	104	Proposed to be essential proteins	Phase 4: April 2009	2GZY	75%	Bacillus anthracis

IDP05033 (show subtarget assignments)	1	cloned	No	BA_1260	30255209		hypothetical protein BA_1260 [Bacillus a...	34	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05258 (show subtarget assignments)	1	soluble	No	CD2761	126700377		putative N-acetylmuramoyl-L-alanine amid...	301	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JWQ	23.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04395 (show subtarget assignments)	1	cloned	No	FTT0076	56707255	sucA	2-oxoglutarate dehydrogenase E1 componen...	941	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2JGD	47.8%	Francisella tularensis

IDP05285 (show subtarget assignments)	1	selected	No	CD0663	126698240	tcdA	toxin A [Clostridium difficile 630]	2710	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3SRZ	20%	Clostridium difficile	Cellular processes: Pathogenesis

IDP05411 (show subtarget assignments)	1	purified	No	BA_2793	30257397		putative chitin binding protein [Bacillu...	455	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2XWX	21.3%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05048 (show subtarget assignments)	1	cloned	No	BA_4771	30259258		conserved hypothetical protein [Bacillus...	289	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05393 (show subtarget assignments)	1	expressed	No	BA_3225	30257788		hypothetical protein BA_3225 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05270 (show subtarget assignments)	1	soluble	No	lmo1016	16803056	gbuC	hypothetical protein lmo1016 [Listeria m...	249	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2B4L	51%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP05257 (show subtarget assignments)	1	crystallized	No	CD2748	126700363		putative transferase [Clostridium diffic...	165	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2EG0	48.2%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP05480 (show subtarget assignments)	1	cloned	No	BA_3532	30258067		putative lipoprotein [Bacillus anthracis...	44	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05255 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0663	57650073	argS	arginyl-tRNA synthetase [Staphylococcus ...	553	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FNR	31.6%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP05256 (show subtarget assignments)	1	cloned	No	BA_1805	30256080		hypothetical protein BA_1805 [Bacillus a...	44	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05261 (show subtarget assignments)	1	cloned	No	CD2772	126700388	tuaG	putative teichuronic acid biosynthesis g...	212	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3BCV	23.6%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91035 (show subtarget assignments)	8	selected	No	SDY_P070	82524476	ospC2	OspC2 [Shigella dysenteriae Sd197]	484	virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...	Community Requests			Shigella dysenteriae

IDP04606 (show subtarget assignments)	1	cloned	No	BAS3692	49186691		tRNA (guanine-N(1)-)-methyltransferase [...	244	Proposed to be essential proteins	Phase 4: April 2009	3KY7	62.3%	Bacillus anthracis

IDP04582 (show subtarget assignments)	1	in_crystallization_trials	No	BAS0110	49183144		50S ribosomal protein L3 [Bacillus anthr...	210	Proposed to be essential proteins	Phase 4: April 2009	1NKW	53.3%	Bacillus anthracis

IDP05259 (show subtarget assignments)	1	cloned	No	CD2782	126700398		cell surface protein [Clostridium diffic...	351	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP05260 (show subtarget assignments)	1	cloned	No	CD2791	126700407		cell surface protein (putative S-layer p...	623	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP05739 (show subtarget assignments)	1	cloned	No	CD2136	126699752	uppS	undecaprenyl pyrophosphate synthetase [C...	244	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F75	52.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04075 (show subtarget assignments)	8	selected	No	CAC05807	12329076	icsB	IcsB, function unknown [Shigella flexner...	494	Shigella effector protein	Community Requests			Shigella flexneri

IDP05609 (show subtarget assignments)	1	expressed	No	BA_5054	30259543		putative S-layer protein [Bacillus anthr...	268	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	19%	Bacillus anthracis	Cell envelope: Surface structures

IDP05264 (show subtarget assignments)	1	expressed	No	CD3257	126700876		putative polysaccharide deacetylase [Clo...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1W17	25.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05263 (show subtarget assignments)	1	cloned	No	CD2793	126700409	slpA	cell surface protein (S-layer precursor ...	719	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3CVZ	36.4%	Clostridium difficile	Cell envelope: Other

IDP05262 (show subtarget assignments)	1	in_pdb 4EBH 3SRT	No	CD0872	126698449	maa	maltose O-acetyltransferase [Clostridium...	185	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3SRT	100%	Clostridium difficile	Cellular processes: Detoxification

IDP05268 (show subtarget assignments)	1	soluble	No	lmo0366	16802411	-	hypothetical protein lmo0366 [Listeria m...	386	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3AT7	25.4%	Listeria monocytogenes	Cell envelope: Other

IDP04264 (show subtarget assignments)	1	cloned	No	CPF_2101	110800507		fibronectin-binding protein [Clostridium...	575	conserved gene; putative drug target function;	Phase 4: April 2009	3DOA	17.7%	Clostridium perfringens	Cellular processes

IDP05266 (show subtarget assignments)	1	purified	No	lmo0047	16802095	-	hypothetical protein lmo0047 [Listeria m...	203	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP05265 (show subtarget assignments)	1	purified	No	CD3543	126701167		putative nicotinate phosphribosyltransfe...	476	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2F7F	43.3%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05272 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1649	16803689	-	hypothetical protein lmo1649 [Listeria m...	171	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP04215 (show subtarget assignments)	1	cloned	No	STM1574_1_495	16764918	smvA	methyl viologen resistance [Salmonella t...	495	Salmonella essential protein	Phase 4: April 2009	2GFP	17%	Salmonella enterica

IDP91208 (show subtarget assignments)	8	purified	No	BT_2186	29347596		3-phosphoshikimate 1-carboxyvinyltransfe...	410	potential drug target / Shikimate pathway enzyme	Community Requests	1EPS	36.2%	Bacteroides thetaiotaomicron

IDP05766 (show subtarget assignments)	1	expressed	No	S0723	30040469		putative helicase [Shigella flexneri 2a ...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2R6A	31.7%	Shigella flexneri	DNA metabolism: DNA replication, recombination, and repair

IDP05415 (show subtarget assignments)	1	soluble	No	BA_5219	30259700		putative ABC transporter, substrate-bind...	268	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EF1	49.6%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05276 (show subtarget assignments)	1	soluble	No	BA_4236	30258739		putative lipoprotein [Bacillus anthracis...	146	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05271 (show subtarget assignments)	1	cloned	No	lmo1194	16803234	cbiD	cobalt-precorrin-6A synthase [Listeria m...	373	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1SR8	23.1%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP04115 (show subtarget assignments)	1	expressed	No	STM2352_1_235	16765679	hisM	histidine/lysine/arginine/ornithine tran...	235	Salmonella essential protein	Phase 4: April 2009	3DHW	23.8%	Salmonella enterica

IDP05275 (show subtarget assignments)	1	soluble	No	lmo2686	16804723	-	hypothetical protein lmo2686 [Listeria m...	177	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP04120 (show subtarget assignments)	1	soluble	No	BAS1475	49184492		xanthine phosphoribosyltransferase [Baci...	197	Proposed to be essential proteins	Phase 4: April 2009	1Y0B	65%	Bacillus anthracis

IDP04068 (show subtarget assignments)	1	expressed	No	YPCD1.94n	40548799		hypothetical protein YPCD1.94n [Yersinia...	251	virulence factor;	Phase 4: April 2009	1A5V	15.1%	Yersinia pestis

IDP04074 (show subtarget assignments)	1	cloned	No	BAS4469	49187464		50S ribosomal protein L20 [Bacillus anth...	118	Proposed to be essential proteins	Phase 4: April 2009	1VS6	55.1%	Bacillus anthracis

IDP05274 (show subtarget assignments)	1	soluble	No	lmo1880	16803919	-	hypothetical protein lmo1880 [Listeria m...	133	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JL2	33.8%	Listeria monocytogenes	Transcription: Degradation of RNA

IDP05273 (show subtarget assignments)	1	soluble	No	lmo1752	16803792	-	hypothetical protein lmo1752 [Listeria m...	251	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes

IDP04069 (show subtarget assignments)	1	in_pdb 3R3T	Yes	BAS5327	49188311		30S ribosomal protein S6 [Bacillus anthr...	96	Proposed to be essential proteins	Phase 4: April 2009	3R3T	100%	Bacillus anthracis

IDP05729 (show subtarget assignments)	1	soluble	No	CD0263	126697835	flhA	flagellar biosynthesis protein FlhA [Clo...	691	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3MIX	22.6%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05283 (show subtarget assignments)	1	soluble	No	CD0229	126697800	flgM	negative regulator of flagellin synthesi...	91	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	27.5%	Clostridium difficile	Regulatory functions: DNA interactions

IDP04258 (show subtarget assignments)	1	soluble	No	CPF_2010	110801347		sensory box histidine kinase [Clostridiu...	571	conserved gene; putative drug target function;	Phase 4: April 2009	3A0R	17.3%	Clostridium perfringens	Regulatory functions

IDP04071 (show subtarget assignments)	1	cloned	No	BAS0129	49183163		50S ribosomal protein L15 [Bacillus anth...	146	Proposed to be essential proteins	Phase 4: April 2009	1VSA	51.4%	Bacillus anthracis

IDP90981 (show subtarget assignments)	8	selected	No	y0850	22124761		outer membrane receptor [Yersinia pestis...	731	other biological interest / putative iron-binding TonB-dependent outer membrane receptor	Community Requests	2HDF	31.1%	Yersinia pestis

IDP05730 (show subtarget assignments)	1	soluble	No	CD0675	126698254		putative acetyltransferase [Clostridium ...	166	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	2GE3	31.3%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP04579 (show subtarget assignments)	1	cloned	No	BAS0098	49183132		50S ribosomal protein L1 [Bacillus anthr...	230	Proposed to be essential proteins	Phase 4: April 2009	3QOY	56.3%	Bacillus anthracis

IDP04070 (show subtarget assignments)	1	cloned	No	FTT0073	56707252	sdhD	succinate dehydrogenase hydrophobic memb...	122	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1NEK	26.2%	Francisella tularensis

IDP91226 (show subtarget assignments)	8	soluble	No	NT04EC4239	26110396	cysG	Siroheme synthase [Escherichia coli CFT0...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	90.2%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91045 (show subtarget assignments)	8	cloned	No	ECH0010	15799700		hypothetical protein Z0021 [Escherichia ...	108	virulence/pathogenesis / Hypothetical protein Z0021 is involved in regulation of swimming motility in E. ...	Community Requests			Escherichia coli

IDP05282 (show subtarget assignments)	1	soluble	No	CD0228	126697799	fliN	flagellar motor switch protein [Clostrid...	104	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1O6A	23.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05395 (show subtarget assignments)	1	cloned	No	BA_2942	30257534		putative lipoprotein [Bacillus anthracis...	86	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05277 (show subtarget assignments)	1	expressed	No	YPO2630	16122843	glnS	glutaminyl-tRNA synthetase [Yersinia pes...	598	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1O0B	80.3%	Yersinia pestis	Protein synthesis: tRNA aminoacylation

IDP05278 (show subtarget assignments)	1	cloned	No	BA_5456	30259924		hypothetical protein BA_5456 [Bacillus a...	49	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05280 (show subtarget assignments)	1	soluble	No	CD0279A	126697852		hypothetical protein CD0279A [Clostridiu...	68	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05279 (show subtarget assignments)	1	in_crystallization_trials	No	CD0254	126697825	flgD	putative basal-body rod modification pro...	202	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP91687 (show subtarget assignments)	8	selected	No	NP_000292	4505881	PLG	plasminogen isoform 1 precursor [Homo sa...	810	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	4DUR	97.7%	Homo sapiens

IDP91686 (show subtarget assignments)	8	selected	No	NP_000236	42741655	MET	hepatocyte growth factor receptor isofor...	1390	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	2UZX	51.4%	Homo sapiens

IDP05228
(show subtarget assignments)

1

soluble

No

lmo0971

16803011

dltD

DltD protein for D-alanine esterificatio...

380

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3BMA

31.6%

Listeria monocytogenes

Cell envelope: Other

IDP05652
(show subtarget assignments)

1

cloned

No

lmo0129

16802177

-

hypothetical protein lmo0129 [Listeria m...

246

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3NE8

27.2%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05253
(show subtarget assignments)

1

cloned

No

CD0259

126697831

putative flagellar protein [Clostridium ...

107

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05010
(show subtarget assignments)

1

soluble

No

BA_4934

30259430

putative lipoprotein [Bacillus anthracis...

144

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05544
(show subtarget assignments)

1

purified

No

Cj1409

6968828

acpS

putative Ni/Fe-hydrogenase small subunit...

115

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3HYK

39.5%

Campylobacter jejuni

Fatty acid and phospholipid metabolism: Biosynthesis

IDP05232
(show subtarget assignments)

1

in_pdb
3TX1

No

lmo1420

16803460

-

hypothetical protein lmo1420 [Listeria m...

298

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3TX1

100%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05240
(show subtarget assignments)

1

expressed

No

CD0233

126697804

hypothetical protein CD0233 [Clostridium...

130

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AJ7

33.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04339
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0115

49183149

50S ribosomal protein L22 [Bacillus anth...

113

Proposed to be essential proteins

Phase 4: April 2009

1BXE

59.3%

Bacillus anthracis

IDP05231
(show subtarget assignments)

1

purified

No

lmo1388

16803428

tcsA

CD4+ T cell-stimulating antigen, lipopro...

346

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

39.9%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP04336
(show subtarget assignments)

8

in_crystallization_trials

No

CAC05790

12329059

ospC1

OspC1, secreted by the Mxi-Spa secretion...

470

Shigella effector protein

Community Requests

Shigella flexneri

IDP05466
(show subtarget assignments)

1

soluble

No

BA_1948

30256606

putative lipoprotein [Bacillus anthracis...

148

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05233
(show subtarget assignments)

1

cloned

No

lmo1455

16803495

dnaG

DNA primase [Listeria monocytogenes EGD-...

626

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2AU3

21.7%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05465
(show subtarget assignments)

1

cloned

No

BA_1580

30255880

conserved hypothetical protein [Bacillus...

159

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05239
(show subtarget assignments)

1

cloned

No

lmo1896

16803935

ansB

asparaginyl-tRNA synthetase [Listeria mo...

430

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

45.3%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05235
(show subtarget assignments)

1

cloned

No

lmo1532

16803572

ruvB

Holliday junction DNA helicase B [Lister...

335

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3PFI

55.2%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05234
(show subtarget assignments)

1

cloned

No

lmo1519

16803559

aspS

aspartyl-tRNA synthetase [Listeria monoc...

591

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1EQR

52.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05237
(show subtarget assignments)

1

soluble

No

lmo1653

16803693

-

putative cellsurface protein [Listeria m...

201

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP05236
(show subtarget assignments)

1

crystallized

No

lmo1533

16803573

ruvA

hypothetical protein lmo1533 [Listeria m...

201

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

34.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05723
(show subtarget assignments)

1

expressed

No

BA_3001

30257589

alkaline phosphatase [Bacillus anthracis...

557

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3A52

25.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP05009
(show subtarget assignments)

1

soluble

No

BA_4237

30258740

putative lipoprotein [Bacillus anthracis...

253

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05724
(show subtarget assignments)

1

soluble

No

BA_3370

30257913

ribonuclease [Bacillus anthracis str. Am...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Transcription: Degradation of RNA

IDP04335
(show subtarget assignments)

1

cloned

No

STM1543_1_428

16764888

putative transport protein [Salmonella t...

428

Salmonella essential protein

Phase 4: April 2009

1PW4

23.4%

Salmonella enterica

IDP05244
(show subtarget assignments)

1

soluble

No

lmo2203

16804242

-

hypothetical protein lmo2203 [Listeria m...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M9S

22.6%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05243
(show subtarget assignments)

1

crystallized

No

lmo2198

16804237

trpS

tryptophanyl-tRNA synthetase [Listeria m...

331

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3PRH

72.2%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP04060
(show subtarget assignments)

8

selected

No

CAC05813

12329082

mxiI

MxiI, component of the Mxi-Spa secretion...

97

Shigella effector protein

Community Requests

Shigella flexneri

IDP05241
(show subtarget assignments)

1

cloned

No

lmo1955

16803994

-

hypothetical protein lmo1955 [Listeria m...

297

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1A0P

43.8%

Listeria monocytogenes

Mobile and extrachromosomal element functions: Prophage functions

IDP05248
(show subtarget assignments)

1

expressed

No

lmo2691

16804728

-

autolysin [Listeria monocytogenes EGD-e]...

590

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

16.1%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05245
(show subtarget assignments)

1

soluble

No

lmo2349

16804387

-

hypothetical protein lmo2349 [Listeria m...

269

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2O1M

71%

Listeria monocytogenes

Transport and binding proteins: Unknown substrate

IDP91154
(show subtarget assignments)

8

in_pdb
3QFG

Yes

SAOUHSC_00808

88194568

hypothetical protein SAOUHSC_00808 [Stap...

242

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3QFG

93.4%

Staphylococcus aureus

IDP05543
(show subtarget assignments)

1

cloned

No

CD2628

126700242

hypothetical protein CD2628 [Clostridium...

642

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05247
(show subtarget assignments)

1

cloned

No

lmo2636

16804674

-

hypothetical protein lmo2636 [Listeria m...

360

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VRM

29.4%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05252
(show subtarget assignments)

1

soluble

No

lmo2854

16804891

-

hypothetical protein lmo2854 [Listeria m...

267

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Cell envelope: Other

IDP05246
(show subtarget assignments)

1

soluble

No

lmo2439

16804477

-

hypothetical protein lmo2439 [Listeria m...

113

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K5Q

33.6%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP91163
(show subtarget assignments)

8

cloned

No

VC1507

15641516

phospho-2-dehydro-3-deoxyheptonate aldol...

395

potential drug target / Shikimate pathway enzyme

Community Requests

1GG1

48.9%

Vibrio cholerae

IDP05046
(show subtarget assignments)

1

expressed

No

BA_3529

30258064

hypothetical protein BA_3529 [Bacillus a...

117

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP04584
(show subtarget assignments)

1

purified

No

BAS0112

49183146

50S ribosomal protein L23 [Bacillus anth...

96

Proposed to be essential proteins

Phase 4: April 2009

1N88

43.8%

Bacillus anthracis

IDP04637
(show subtarget assignments)

1

cloned

No

FTT0371c

56707522

folC

FolC bifunctional protein [Francisella t...

393

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1W78

29.8%

Francisella tularensis

IDP04067
(show subtarget assignments)

1

purified

No

BAS4417

49187412

thioredoxin [Bacillus anthracis str. Ste...

104

Proposed to be essential proteins

Phase 4: April 2009

2GZY

75%

Bacillus anthracis

IDP05033
(show subtarget assignments)

1

cloned

No

BA_1260

30255209

hypothetical protein BA_1260 [Bacillus a...

34

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05258
(show subtarget assignments)

1

soluble

No

CD2761

126700377

putative N-acetylmuramoyl-L-alanine amid...

301

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JWQ

23.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04395
(show subtarget assignments)

1

cloned

No

FTT0076

56707255

sucA

2-oxoglutarate dehydrogenase E1 componen...

941

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2JGD

47.8%

Francisella tularensis

IDP05285
(show subtarget assignments)

1

selected

No

CD0663

126698240

tcdA

toxin A [Clostridium difficile 630]

2710

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3SRZ

20%

Clostridium difficile

Cellular processes: Pathogenesis

IDP05411
(show subtarget assignments)

1

purified

No

BA_2793

30257397

putative chitin binding protein [Bacillu...

455

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2XWX

21.3%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05048
(show subtarget assignments)

1

cloned

No

BA_4771

30259258

conserved hypothetical protein [Bacillus...

289

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05393
(show subtarget assignments)

1

expressed

No

BA_3225

30257788

hypothetical protein BA_3225 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05270
(show subtarget assignments)

1

soluble

No

lmo1016

16803056

gbuC

hypothetical protein lmo1016 [Listeria m...

249

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2B4L

51%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP05257
(show subtarget assignments)

1

crystallized

No

CD2748

126700363

putative transferase [Clostridium diffic...

165

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2EG0

48.2%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP05480
(show subtarget assignments)

1

cloned

No

BA_3532

30258067

putative lipoprotein [Bacillus anthracis...

44

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05255
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0663

57650073

argS

arginyl-tRNA synthetase [Staphylococcus ...

553

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FNR

31.6%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP05256
(show subtarget assignments)

1

cloned

No

BA_1805

30256080

hypothetical protein BA_1805 [Bacillus a...

44

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05261
(show subtarget assignments)

1

cloned

No

CD2772

126700388

tuaG

putative teichuronic acid biosynthesis g...

212

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3BCV

23.6%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91035
(show subtarget assignments)

8

selected

No

SDY_P070

82524476

ospC2

OspC2 [Shigella dysenteriae Sd197]

484

virulence/pathogenesis / A cell surface protein of S. dysenteriae and putative virulence factor secreted ...

Community Requests

Shigella dysenteriae

IDP04606
(show subtarget assignments)

1

cloned

No

BAS3692

49186691

tRNA (guanine-N(1)-)-methyltransferase [...

244

Proposed to be essential proteins

Phase 4: April 2009

3KY7

62.3%

Bacillus anthracis

IDP04582
(show subtarget assignments)

1

in_crystallization_trials

No

BAS0110

49183144

50S ribosomal protein L3 [Bacillus anthr...

210

Proposed to be essential proteins

Phase 4: April 2009

1NKW

53.3%

Bacillus anthracis

IDP05259
(show subtarget assignments)

1

cloned

No

CD2782

126700398

cell surface protein [Clostridium diffic...

351

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP05260
(show subtarget assignments)

1

cloned

No

CD2791

126700407

cell surface protein (putative S-layer p...

623

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP05739
(show subtarget assignments)

1

cloned

No

CD2136

126699752

uppS

undecaprenyl pyrophosphate synthetase [C...

244

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F75

52.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04075
(show subtarget assignments)

8

selected

No

CAC05807

12329076

icsB

IcsB, function unknown [Shigella flexner...

494

Shigella effector protein

Community Requests

Shigella flexneri

IDP05609
(show subtarget assignments)

1

expressed

No

BA_5054

30259543

putative S-layer protein [Bacillus anthr...

268

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

19%

Bacillus anthracis

Cell envelope: Surface structures

IDP05264
(show subtarget assignments)

1

expressed

No

CD3257

126700876

putative polysaccharide deacetylase [Clo...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1W17

25.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05263
(show subtarget assignments)

1

cloned

No

CD2793

126700409

slpA

cell surface protein (S-layer precursor ...

719

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3CVZ

36.4%

Clostridium difficile

Cell envelope: Other

IDP05262
(show subtarget assignments)

1

in_pdb
4EBH
3SRT

No

CD0872

126698449

maa

maltose O-acetyltransferase [Clostridium...

185

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3SRT

100%

Clostridium difficile

Cellular processes: Detoxification

IDP05268
(show subtarget assignments)

1

soluble

No

lmo0366

16802411

-

hypothetical protein lmo0366 [Listeria m...

386

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3AT7

25.4%

Listeria monocytogenes

Cell envelope: Other

IDP04264
(show subtarget assignments)

1

cloned

No

CPF_2101

110800507

fibronectin-binding protein [Clostridium...

575

conserved gene; putative drug target function;

Phase 4: April 2009

3DOA

17.7%

Clostridium perfringens

Cellular processes

IDP05266
(show subtarget assignments)

1

purified

No

lmo0047

16802095

-

hypothetical protein lmo0047 [Listeria m...

203

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP05265
(show subtarget assignments)

1

purified

No

CD3543

126701167

putative nicotinate phosphribosyltransfe...

476

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2F7F

43.3%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP05272
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1649

16803689

-

hypothetical protein lmo1649 [Listeria m...

171

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP04215
(show subtarget assignments)

1

cloned

No

STM1574_1_495

16764918

smvA

methyl viologen resistance [Salmonella t...

495

Salmonella essential protein

Phase 4: April 2009

2GFP

17%

Salmonella enterica

IDP91208
(show subtarget assignments)

8

purified

No

BT_2186

29347596

3-phosphoshikimate 1-carboxyvinyltransfe...

410

potential drug target / Shikimate pathway enzyme

Community Requests

1EPS

36.2%

Bacteroides thetaiotaomicron

IDP05766
(show subtarget assignments)

1

expressed

No

S0723

30040469

putative helicase [Shigella flexneri 2a ...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2R6A

31.7%

Shigella flexneri

DNA metabolism: DNA replication, recombination, and repair

IDP05415
(show subtarget assignments)

1

soluble

No

BA_5219

30259700

putative ABC transporter, substrate-bind...

268

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EF1

49.6%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05276
(show subtarget assignments)

1

soluble

No

BA_4236

30258739

putative lipoprotein [Bacillus anthracis...

146

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05271
(show subtarget assignments)

1

cloned

No

lmo1194

16803234

cbiD

cobalt-precorrin-6A synthase [Listeria m...

373

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1SR8

23.1%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP04115
(show subtarget assignments)

1

expressed

No

STM2352_1_235

16765679

hisM

histidine/lysine/arginine/ornithine tran...

235

Salmonella essential protein

Phase 4: April 2009

3DHW

23.8%

Salmonella enterica

IDP05275
(show subtarget assignments)

1

soluble

No

lmo2686

16804723

-

hypothetical protein lmo2686 [Listeria m...

177

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP04120
(show subtarget assignments)

1

soluble

No

BAS1475

49184492

xanthine phosphoribosyltransferase [Baci...

197

Proposed to be essential proteins

Phase 4: April 2009

1Y0B

65%

Bacillus anthracis

IDP04068
(show subtarget assignments)

1

expressed

No

YPCD1.94n

40548799

hypothetical protein YPCD1.94n [Yersinia...

251

virulence factor;

Phase 4: April 2009

1A5V

15.1%

Yersinia pestis

IDP04074
(show subtarget assignments)

1

cloned

No

BAS4469

49187464

50S ribosomal protein L20 [Bacillus anth...

118

Proposed to be essential proteins

Phase 4: April 2009

1VS6

55.1%

Bacillus anthracis

IDP05274
(show subtarget assignments)

1

soluble

No

lmo1880

16803919

-

hypothetical protein lmo1880 [Listeria m...

133

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JL2

33.8%

Listeria monocytogenes

Transcription: Degradation of RNA

IDP05273
(show subtarget assignments)

1

soluble

No

lmo1752

16803792

-

hypothetical protein lmo1752 [Listeria m...

251

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

IDP04069
(show subtarget assignments)

1

in_pdb
3R3T

Yes

BAS5327

49188311

30S ribosomal protein S6 [Bacillus anthr...

96

Proposed to be essential proteins

Phase 4: April 2009

3R3T

100%

Bacillus anthracis

IDP05729
(show subtarget assignments)

1

soluble

No

CD0263

126697835

flhA

flagellar biosynthesis protein FlhA [Clo...

691

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3MIX

22.6%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05283
(show subtarget assignments)

1

soluble

No

CD0229

126697800

flgM

negative regulator of flagellin synthesi...

91

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

27.5%

Clostridium difficile

Regulatory functions: DNA interactions

IDP04258
(show subtarget assignments)

1

soluble

No

CPF_2010

110801347

sensory box histidine kinase [Clostridiu...

571

conserved gene; putative drug target function;

Phase 4: April 2009

3A0R

17.3%

Clostridium perfringens

Regulatory functions

IDP04071
(show subtarget assignments)

1

cloned

No

BAS0129

49183163

50S ribosomal protein L15 [Bacillus anth...

146

Proposed to be essential proteins

Phase 4: April 2009

1VSA

51.4%

Bacillus anthracis

IDP90981
(show subtarget assignments)

8

selected

No

y0850

22124761

outer membrane receptor [Yersinia pestis...

731

other biological interest / putative iron-binding TonB-dependent outer membrane receptor

Community Requests

2HDF

31.1%

Yersinia pestis

IDP05730
(show subtarget assignments)

1

soluble

No

CD0675

126698254

putative acetyltransferase [Clostridium ...

166

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

2GE3

31.3%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP04579
(show subtarget assignments)

1

cloned

No

BAS0098

49183132

50S ribosomal protein L1 [Bacillus anthr...

230

Proposed to be essential proteins

Phase 4: April 2009

3QOY

56.3%

Bacillus anthracis

IDP04070
(show subtarget assignments)

1

cloned

No

FTT0073

56707252

sdhD

succinate dehydrogenase hydrophobic memb...

122

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1NEK

26.2%

Francisella tularensis

IDP91226
(show subtarget assignments)

8

soluble

No

NT04EC4239

26110396

cysG

Siroheme synthase [Escherichia coli CFT0...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

90.2%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91045
(show subtarget assignments)

8

cloned

No

ECH0010

15799700

hypothetical protein Z0021 [Escherichia ...

108

virulence/pathogenesis / Hypothetical protein Z0021 is involved in regulation of swimming motility in E. ...

Community Requests

Escherichia coli

IDP05282
(show subtarget assignments)

1

soluble

No

CD0228

126697799

fliN

flagellar motor switch protein [Clostrid...

104

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1O6A

23.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05395
(show subtarget assignments)

1

cloned

No

BA_2942

30257534

putative lipoprotein [Bacillus anthracis...

86

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05277
(show subtarget assignments)

1

expressed

No

YPO2630

16122843

glnS

glutaminyl-tRNA synthetase [Yersinia pes...

598

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1O0B

80.3%

Yersinia pestis

Protein synthesis: tRNA aminoacylation

IDP05278
(show subtarget assignments)

1

cloned

No

BA_5456

30259924

hypothetical protein BA_5456 [Bacillus a...

49

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05280
(show subtarget assignments)

1

soluble

No

CD0279A

126697852

hypothetical protein CD0279A [Clostridiu...

68

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05279
(show subtarget assignments)

1

in_crystallization_trials

No

CD0254

126697825

flgD

putative basal-body rod modification pro...

202

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP91687
(show subtarget assignments)

8

selected

No

NP_000292

4505881

PLG

plasminogen isoform 1 precursor [Homo sa...

810

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

4DUR

97.7%

Homo sapiens

IDP91686
(show subtarget assignments)

8

selected

No

NP_000236

42741655

MET

hepatocyte growth factor receptor isofor...

1390

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

2UZX

51.4%

Homo sapiens