Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02348 (show subtarget assignments)	1	soluble	No	GBAA2803	47528096		S-layer protein, putative [Bacillus anth...	461	Drug target motif; Drug target functions	Phase 3: June 2008	3PYW	12.4%	Bacillus anthracis	Cell envelope	Surface structures

IDP04058 (show subtarget assignments)	1	soluble	No	CPF_0556	110800185		ABC transporter, solute-binding protein ...	461	drug target; putative drug target function;	Phase 4: April 2009	1EU8	18.9%	Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP01642 (show subtarget assignments)	1	cloned	No	Cj1150c	15792474	waaE	D,D-heptose 1-phosphate adenosyltransfer...	461	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	2AWD	15.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02129 (show subtarget assignments)	1	expressed	No	CBU_0450	29541057	ffh	signal recognition particle protein [Cox...	461	Conserved; Drug target functions	Phase 3: June 2008	2XXA	57.3%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP90916 (show subtarget assignments)	8	soluble	No	YPO3073	16123250	cysS	cysteinyl-tRNA synthetase [Yersinia pest...	461	Predicted Essential	Community Requests	1LI5	83.9%	Yersinia pestis

IDP01385 (show subtarget assignments)	1	cloned	No	VC0560	15640582		signal recognition particle protein	461	Drug Target Function	Phase 2: March 2008	2XXA	73.1%	Vibrio cholerae	Protein fate	Protein and peptide secretion and trafficking

IDP02097 (show subtarget assignments)	1	cloned	No	Cj0195	15791582	fliI	flagellum-specific ATP synthase [Campylo...	461	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	2DPY	40.3%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP90621 (show subtarget assignments)	8	soluble	No	Cj0931c	15792260	argH	argininosuccinate lyase [Campylobacter j...	460	Predicted Essential	Community Requests	1AUW	44.8%	Campylobacter jejuni

IDP92106 (show subtarget assignments)	8	selected	No	TGME49_079450	237845375		adenylosuccinate synthetase, putative [T...	460	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1P9B	48.7%	Toxoplasma gondii

IDP00465 (show subtarget assignments)	1	cloned	No	YPO1062	16121362	tilS	tRNA(Ile)-lysidine synthetase	460	Virulence Associated Factor	Phase 2: March 2008	1NI5	52.8%	Yersinia pestis	Cellular processes	Cell division

IDP00185 (show subtarget assignments)	1	cloned	No	YPO0639	16120963	-	hypothetical protein	460	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP02476 (show subtarget assignments)	1	cloned	No	YPO1776	16122030	dbpA	ATP-dependent RNA helicase DbpA [Yersini...	460	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2I4I	30%	Yersinia pestis	Transcription	Transcription factors

IDP90577 (show subtarget assignments)	8	soluble	No	VC1848	15641850	cysS	cysteinyl-tRNA synthetase [Vibrio choler...	459	Predicted Essential	Community Requests	1LI5	75.1%	Vibrio cholerae

IDP05540 (show subtarget assignments)	1	cloned	No	CD3515	126701139	glmU	bifunctional protein [Clostridium diffic...	459	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	4AAW	48.4%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP02244 (show subtarget assignments)	1	cloned	No	GBAA1818	47777969		N-acetylmuramoyl-L-alanine amidase [Baci...	459	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	3PYW	12.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01179 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0048	81583548		Bifunctional protein glmU [Includes: UDP...	459	Drug Target Function	Phase 2: March 2008	1G95	51.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02696 (show subtarget assignments)	1	soluble	No	GBAA2773	47528064	acoL	dihydrolipoamide dehydrogenase [Bacillus...	459	Conserved; Drug target functions	Phase 3: June 2008	2QAE	40.6%	Bacillus anthracis	Energy metabolism	Fermentation

IDP02576 (show subtarget assignments)	1	purified	No	GBAA0246	47525503	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	458	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2AM1	37.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04419 (show subtarget assignments)	1	soluble	No	GBAA2861	47528156		sensor histidine kinase SrrB, putative [...	458	putative drug target function;	Phase 4: April 2009	2C2A	18.1%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP90850 (show subtarget assignments)	8	soluble	No	YPO0551	16120879	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	458	Predicted Essential	Community Requests	1GG4	69.9%	Yersinia pestis

IDP02615 (show subtarget assignments)	1	expressed	No	GBAA4677	47529976		ribonuclease [Bacillus anthracis str. 'A...	458	Conserved; Drug target functions	Phase 3: June 2008	2BX2	27.7%	Bacillus anthracis	Cellular processes	Cell division

IDP05073 (show subtarget assignments)	1	expressed	No	Cj0562	6968026	dnaB	gamma-glutamyl phosphate reductase [Camp...	439	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2VYE	37.1%	Campylobacter jejuni	DNA metabolism: DNA replication, recombination, and repair

IDP01962 (show subtarget assignments)	1	in_pdb 3IJ3	Yes	CBU_0572	29541173		cytosol aminopeptidase family protein [C...	458	Conserved; Drug target functions	Phase 3: June 2008	3IJ3	100%	Coxiella burnetii	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02208 (show subtarget assignments)	1	cloned	No	FTT0964c	56708058	ffh	signal recognition particle protein, Ffh...	458	Conserved; Drug target functions	Phase 3: June 2008	2XXA	59%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP02648 (show subtarget assignments)	1	soluble	No	FTT0064	56707243	atpD	F0F1 ATP synthase subunit beta [Francise...	458	Conserved; Drug target functions	Phase 3: June 2008	3OAA	81.3%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP05146 (show subtarget assignments)	1	cloned	No	BAS4784	49187774	-	glycyl-tRNA synthetase [Bacillus anthrac...	458	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1ATI	43.2%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP02155 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0239	16120577	trkA	potassium transporter peripheral membran...	458	Conserved; CD; Drug target functions	Phase 3: June 2008	1LSS	12.2%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP91398 (show subtarget assignments)	8	soluble	No	VV1_1045	27364477	trkA	potassium transporter peripheral membran...	458	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3L4B	12.7%	Vibrio vulnificus

IDP04438 (show subtarget assignments)	1	expressed	No	YPO0073	115345903	cpxA	two component sensor kinase [Yersinia pe...	458	conserved gene; putative drug target function;	Phase 4: April 2009	2C2A	16.8%	Yersinia pestis	Regulatory functions	Other

IDP00537 (show subtarget assignments)	1	purified	No	YPO3924	16124055	argH	argininosuccinate lyase	457	Conserved Gene / Pathway	Phase 2: March 2008	1TJ7	88.8%	Yersinia pestis	Amino acid biosynthesis	Glutamate family

IDP91293 (show subtarget assignments)	8	soluble	No	SPA3343	56415395	cysG	siroheme synthase [Salmonella enterica s...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	99.6%	Salmonella enterica

IDP91226 (show subtarget assignments)	8	soluble	No	NT04EC4239	26110396	cysG	Siroheme synthase [Escherichia coli CFT0...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	90.2%	Escherichia coli	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91222 (show subtarget assignments)	8	soluble	No	SF3387	24114633	cysG	siroheme synthase [Shigella flexneri 2a ...	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	90.2%	Shigella flexneri

IDP91305 (show subtarget assignments)	8	soluble	No	STM3477	16766765	cysG	siroheme synthase	457	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	99.8%	Salmonella enterica

IDP00356 (show subtarget assignments)	1	purified	No	lmo0198	16802244	gcaD	hypothetical protein lmo0198	457	Predicted involvement in glycosyl group metabolism; Drug Target Homologs	Phase 2: March 2008	1HM0	54.3%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04397 (show subtarget assignments)	1	expressed	No	GBAA3230	47528520		sensor histidine kinase [Bacillus anthra...	457	putative drug target function;	Phase 4: April 2009	2C2A	17.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP00624 (show subtarget assignments)	8	in_pdb 3T41 3QFH	No	SACOL1874	57284795	epiP	epidermin leader peptide processing seri...	457	Drug Target Function	Community Requests	3QFH	94.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP05742 (show subtarget assignments)	1	cloned	No	CD2655	126700269	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	457	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1GG4	31.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04373 (show subtarget assignments)	1	cloned	No	YPO3097	218930139	manB	phosphomannomutase [Yersinia pestis CO92...	457	drug target; virulence factor; putative drug target function;	Phase 4: April 2009	3UW2	37.8%	Yersinia pestis	Energy metabolism	Sugars

IDP00476 (show subtarget assignments)	1	soluble	No	YPO0063	161486895		hypothetical protein YPO0063	456	Virulence Associated Factor	Phase 2: March 2008	1I84	13.4%	Yersinia pestis	Cell envelope	Other

IDP01807 (show subtarget assignments)	1	cloned	No	FTT0873c	56707977	radA	DNA repair protein RadA [Francisella tul...	456	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3K1J	15.1%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP00467 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1974	16122218		N-formimino-L-glutamate deiminase	456	Conserved Gene / Pathway	Phase 2: March 2008	3MDU	59.2%	Yersinia pestis	Cellular processes	Detoxification

IDP02269 (show subtarget assignments)	1	cloned	No	Cj0608	15791968		outer membrane efflux protein [Campyloba...	456	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	3PIK	23.7%	Campylobacter jejuni	Protein fate	Protein folding and stabilization

IDP00427 (show subtarget assignments)	1	in_pdb 3FWW	No	YPO4119	16124227	glmU	bifunctional N-acetylglucosamine-1-phosp...	456	Drug Target Function	Phase 2: March 2008	3FWW	100%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02814 (show subtarget assignments)	1	cloned	No	FTT0709	56707828	eno	enolase (2-phosphoglycerate dehydratase)...	456	Conserved; Drug target functions	Phase 3: June 2008	1IYX	60.5%	Francisella tularensis	Energy metabolism	Glycolysis/gluconeogenesis

IDP05637 (show subtarget assignments)	1	cloned	No	CD2518	126700135		cell surface protein [Clostridium diffic...	456	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP01387 (show subtarget assignments)	1	cloned	No	VC0566	15640588		protease DO	456	Drug Target Function	Phase 2: March 2008	2ZLE	57.7%	Vibrio cholerae	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02373 (show subtarget assignments)	1	expressed	No	FTT0438	56707582	mpl	UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	456	Conserved; Drug target functions	Phase 3: June 2008	3HN7	41.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00582 (show subtarget assignments)	1	in_pdb 3GSE	Yes	YPO2528	16122747	menF	menaquinone-specific isochorismate synth...	455	Conserved Gene / Pathway	Phase 2: March 2008	3GSE	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Menaquinone and ubiquinone

IDP02087 (show subtarget assignments)	1	in_crystallization_trials	No	STM3348	16766643	degQ	serine endoprotease [Salmonella typhimur...	455	Drug target motif; Conserved; Drug target functions	Phase 3: June 2008	4A8A	84.4%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP01041 (show subtarget assignments)	1	purified	No	STM2971	16766276	sdaB	L-serine dehydratase/L-threonine deamina...	455	Conserved Gene / Pathway	Phase 2: March 2008	2IQQ	16%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP05203 (show subtarget assignments)	1	cloned	No	CD1708	126699315		hypothetical protein CD1708 [Clostridium...	455	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP02698 (show subtarget assignments)	1	purified	No	FTT0387	56707536	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	3FWW	51%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05411 (show subtarget assignments)	1	purified	No	BA_2793	30257397		putative chitin binding protein [Bacillu...	455	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2XWX	21.3%	Bacillus anthracis	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01620 (show subtarget assignments)	1	cloned	No	FTT0687c	56707807	hslU	ATP-dependent protease ATP-binding subun...	455	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1DO0	64.6%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP91584 (show subtarget assignments)	8	expressed	No	CBU_0425	29541034		hypothetical protein	455	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Coxiella burnetii

IDP00741 (show subtarget assignments)	1	purified	No	SACOL1253	57285992	ffh	signal recognition particle protein	455	Drug Target Function	Phase 2: March 2008	2XXA	49.5%	Staphylococcus aureus	Protein fate	Protein and peptide secretion and trafficking

IDP00318 (show subtarget assignments)	1	cloned	No	CBU_1947	29655231	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Drug Target Function	Phase 2: March 2008	1HV9	51.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04527 (show subtarget assignments)	1	cloned	No	STM1824_1_454	16765165	pabB	para-aminobenzoate synthase component I ...	454	Salmonella essential protein	Phase 4: April 2009	1K0E	76.2%	Salmonella enterica

IDP02466 (show subtarget assignments)	1	crystallized	No	YPO1771	16122025		L-serine dehydratase [Yersinia pestis CO...	454	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...	Phase 3: June 2008	2IQQ	17%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP05130 (show subtarget assignments)	1	cloned	No	CD0119	126697691		phosphoglucomutase/phosphomannomutase mu...	454	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3PDK	50.2%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP00350 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1633	16803673	trpE	anthranilate synthase component I	454	Drug Target Function	Phase 2: March 2008	1QDL	35.7%	Listeria monocytogenes	Amino acid biosynthesis	Aromatic amino acid family

IDP02716 (show subtarget assignments)	1	cloned	No	GBAA0325	47525592	gabT	4-aminobutyrate aminotransferase [Bacill...	454	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1SF2	45.2%	Bacillus anthracis	Central intermediary metabolism	Other

IDP05738 (show subtarget assignments)	1	cloned	No	CD2090	126699707		putative xanthine/uracile permease [Clos...	453	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3QE7	28%	Clostridium difficile	Transport and binding proteins: Nucleosides, purines and pyrimidines

IDP01871 (show subtarget assignments)	1	cloned	No	FTT1795c	56708783	trpC	bifunctional indole-3-glycerol phosphate...	453	Conserved; Drug target functions	Phase 3: June 2008	1PII	56.1%	Francisella tularensis	Amino acid biosynthesisFatty acid and phospholipid metabolism	Aromatic amino acid familyHistidine family,Biosynthesis

IDP02152 (show subtarget assignments)	1	soluble	No	FTT0955c	56708049	gor	glutathione reductase [Francisella tular...	453	Conserved; Drug target functions	Phase 3: June 2008	1GER	49.2%	Francisella tularensis	Energy metabolism	Electron transport

IDP91736 (show subtarget assignments)	8	selected	No	Q51451_PSEAE	0			453	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1R4T	30.7%	Pseudomonas aeruginosa

IDP91999 (show subtarget assignments)	8	selected	No	SpneCM_010100004482	298254857		BlpC ABC transporter [Streptococcus pneu...	453	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP04627 (show subtarget assignments)	8	cloned	No	BAS5321	49188305		replicative DNA helicase [Bacillus anthr...	453	Proposed to be essential proteins	Community Requests	2VYE	75.3%	Bacillus anthracis

IDP91308 (show subtarget assignments)	8	soluble	No	VV2_0483	27366917		membrane-fusion protein [Vibrio vulnific...	453	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91748 (show subtarget assignments)	8	selected	No	Q933J5_PSEAE	0			453	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1R4T	30.5%	Pseudomonas aeruginosa

IDP01477 (show subtarget assignments)	1	purified	No	VC2762	15642755	glmU	bifunctional N-acetylglucosamine-1-phosp...	453	Drug Target Function	Phase 2: March 2008	1HV9	67.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455 (show subtarget assignments)	1	purified	No	VC2405	15642402		UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	453	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	52.5%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90744 (show subtarget assignments)	8	expressed	No	Cj1059c	15792386	gatA	aspartyl/glutamyl-tRNA amidotransferase ...	453	Predicted Essential	Community Requests	3H0L	47.9%	Campylobacter jejuni

IDP91566 (show subtarget assignments)	8	cloned	No	BAB34991	13361032	ECs1568	hypothetical protein [Escherichia coli O...	453	virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Escherichia coli

IDP04272 (show subtarget assignments)	1	expressed	No	GBAA3899	47529188		lantibiotic biosynthesis sensor histidin...	453	putative drug target function;	Phase 4: April 2009	2C2A	14.3%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP90901 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3273	16123430	pssA	phosphatidylserine synthase [Yersinia pe...	452	Predicted Essential	Community Requests	3HSI	50.3%	Yersinia pestis

IDP00904 (show subtarget assignments)	0	work_stopped	No	STM0124	16763514	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	1GG4	87.6%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02368 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0422	56707569	murF	UDP-N--acetylmuramoylalanyl-D-glutamyl-2...	452	Conserved; Drug target functions	Phase 3: June 2008	1GG4	33.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04076 (show subtarget assignments)	1	expressed	No	GBAA2213	47527506		sensor histidine kinase [Bacillus anthra...	452	putative drug target function;	Phase 4: April 2009	2C2A	18.6%	Bacillus anthracis	Regulatory functions	Protein interactions

IDP00689 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2073	57284941	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	2AM1	33.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05762 (show subtarget assignments)	1	soluble	No	lmo2119	16804158	-	hypothetical protein lmo2119 [Listeria m...	453	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KXY	7.1%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP02309 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0239	56707396	murC	UDP-N-acetylmuramate--alanine ligase [Fr...	451	Conserved; Drug target functions	Phase 3: June 2008	2F00	36.1%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05294 (show subtarget assignments)	1	cloned	No	CD1418	126699021		putative drug/sodium antiporter [Clostri...	451	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	3MKT	20.6%	Clostridium difficile	Transport and binding proteins: Other

IDP00196 (show subtarget assignments)	1	cloned	No	YPO1051	16121351	-	putative membrane protein	451	Virulence	Phase 1: October 2007	2ZPL	13.5%	Yersinia pestis

IDP91415 (show subtarget assignments)	8	cloned	No	VV1_0698	27364154		Mg/Co/Ni transporter MgtE [Vibrio vulnif...	451	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2YVX	29%	Vibrio vulnificus

IDP05743 (show subtarget assignments)	1	cloned	No	CD2653	126700267	murD	UDP-N-acetylmuramoylalanine--D-glutamate...	451	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3LK7	38.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01466 (show subtarget assignments)	1	in_crystallization_trials	No	VC2542	15642537		UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...	451	Conserved Gene / Pathway	Phase 2: March 2008	3HN7	51%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04711 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0513	115346323		conserved hypothetical protein [Yersinia...	451	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP00694 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2151	57286365	glmM	phosphoglucosamine mutase GlmM	451	Drug Target Function	Phase 2: March 2008	3PDK	67.4%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00111 (show subtarget assignments)	1	in_pdb 3TV9	No	NT02SF4808	30043741	pmbA	putative peptide maturation protein	450	Virulence	Phase 1: October 2007	3TV9	96.2%	Shigella flexneri	Cellular processes	Toxin production and resistance

IDP04725 (show subtarget assignments)	1	selected	No	YPO1467	115347221		conserved hypothetical protein [Yersinia...	450	virulence factor;	Phase 4: April 2009			Yersinia pestis	Hypothetical proteins	Conserved

IDP00204 (show subtarget assignments)	1	expressed	No	YPO1702	16121962	-	putative membrane protein	450	Virulence	Phase 1: October 2007			Yersinia pestis	Hypothetical proteins	Conserved

IDP02748 (show subtarget assignments)	1	expressed	No	GBAA4408	47529702	accC	acetyl-CoA carboxylase biotin carboxylas...	450	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	2VPQ	66.4%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP04649 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1283	56708343	trmE	tRNA modification GTPase TrmE [Francisel...	450	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XZP	36.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP01650 (show subtarget assignments)	1	in_pdb 3IFS	No	GBAA5130	47530435	pgi	glucose-6-phosphate isomerase [Bacillus ...	450	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3IFS	100%	Bacillus anthracis	Energy metabolism	Glycolysis/gluconeogenesis

IDP05036 (show subtarget assignments)	1	cloned	No	BA_1663	30255960		hypothetical protein BA_1663 [Bacillus a...	450	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis

IDP05546 (show subtarget assignments)	1	cloned	No	lmo0054	16802102	dnaC	replicative DNA helicase [Listeria monoc...	450	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 5: 2010	2R6A	77.1%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP05161 (show subtarget assignments)	1	cloned	No	BA_1671	30255967		putative flagellar hook-associated FliD ...	450	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cellular processes: Chemotaxis and motility

IDP00656 (show subtarget assignments)	1	cloned	No	SACOL0543	57284226	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	450	Drug Target Function	Phase 2: March 2008	1G95	49.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02348
(show subtarget assignments)

1

soluble

No

GBAA2803

47528096

S-layer protein, putative [Bacillus anth...

461

Drug target motif; Drug target functions

Phase 3: June 2008

3PYW

12.4%

Bacillus anthracis

Cell envelope

Surface structures

IDP04058
(show subtarget assignments)

1

soluble

No

CPF_0556

110800185

ABC transporter, solute-binding protein ...

461

drug target; putative drug target function;

Phase 4: April 2009

1EU8

18.9%

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP01642
(show subtarget assignments)

1

cloned

No

Cj1150c

15792474

waaE

D,D-heptose 1-phosphate adenosyltransfer...

461

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

2AWD

15.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02129
(show subtarget assignments)

1

expressed

No

CBU_0450

29541057

ffh

signal recognition particle protein [Cox...

461

Conserved; Drug target functions

Phase 3: June 2008

2XXA

57.3%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP90916
(show subtarget assignments)

8

soluble

No

YPO3073

16123250

cysS

cysteinyl-tRNA synthetase [Yersinia pest...

461

Predicted Essential

Community Requests

1LI5

83.9%

Yersinia pestis

IDP01385
(show subtarget assignments)

1

cloned

No

VC0560

15640582

signal recognition particle protein

461

Drug Target Function

Phase 2: March 2008

2XXA

73.1%

Vibrio cholerae

Protein fate

Protein and peptide secretion and trafficking

IDP02097
(show subtarget assignments)

1

cloned

No

Cj0195

15791582

fliI

flagellum-specific ATP synthase [Campylo...

461

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

2DPY

40.3%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP90621
(show subtarget assignments)

8

soluble

No

Cj0931c

15792260

argH

argininosuccinate lyase [Campylobacter j...

460

Predicted Essential

Community Requests

1AUW

44.8%

Campylobacter jejuni

IDP92106
(show subtarget assignments)

8

selected

No

TGME49_079450

237845375

adenylosuccinate synthetase, putative [T...

460

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1P9B

48.7%

Toxoplasma gondii

IDP00465
(show subtarget assignments)

1

cloned

No

YPO1062

16121362

tilS

tRNA(Ile)-lysidine synthetase

460

Virulence Associated Factor

Phase 2: March 2008

1NI5

52.8%

Yersinia pestis

Cellular processes

Cell division

IDP00185
(show subtarget assignments)

1

cloned

No

YPO0639

16120963

-

hypothetical protein

460

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP02476
(show subtarget assignments)

1

cloned

No

YPO1776

16122030

dbpA

ATP-dependent RNA helicase DbpA [Yersini...

460

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2I4I

30%

Yersinia pestis

Transcription

Transcription factors

IDP90577
(show subtarget assignments)

8

soluble

No

VC1848

15641850

cysS

cysteinyl-tRNA synthetase [Vibrio choler...

459

Predicted Essential

Community Requests

1LI5

75.1%

Vibrio cholerae

IDP05540
(show subtarget assignments)

1

cloned

No

CD3515

126701139

glmU

bifunctional protein [Clostridium diffic...

459

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

4AAW

48.4%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP02244
(show subtarget assignments)

1

cloned

No

GBAA1818

47777969

N-acetylmuramoyl-L-alanine amidase [Baci...

459

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

3PYW

12.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01179
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0048

81583548

Bifunctional protein glmU [Includes: UDP...

459

Drug Target Function

Phase 2: March 2008

1G95

51.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02696
(show subtarget assignments)

1

soluble

No

GBAA2773

47528064

acoL

dihydrolipoamide dehydrogenase [Bacillus...

459

Conserved; Drug target functions

Phase 3: June 2008

2QAE

40.6%

Bacillus anthracis

Energy metabolism

Fermentation

IDP02576
(show subtarget assignments)

1

purified

No

GBAA0246

47525503

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

458

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2AM1

37.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04419
(show subtarget assignments)

1

soluble

No

GBAA2861

47528156

sensor histidine kinase SrrB, putative [...

458

putative drug target function;

Phase 4: April 2009

2C2A

18.1%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP90850
(show subtarget assignments)

8

soluble

No

YPO0551

16120879

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

458

Predicted Essential

Community Requests

1GG4

69.9%

Yersinia pestis

IDP02615
(show subtarget assignments)

1

expressed

No

GBAA4677

47529976

ribonuclease [Bacillus anthracis str. 'A...

458

Conserved; Drug target functions

Phase 3: June 2008

2BX2

27.7%

Bacillus anthracis

Cellular processes

Cell division

IDP05073
(show subtarget assignments)

1

expressed

No

Cj0562

6968026

dnaB

gamma-glutamyl phosphate reductase [Camp...

439

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2VYE

37.1%

Campylobacter jejuni

DNA metabolism: DNA replication, recombination, and repair

IDP01962
(show subtarget assignments)

1

in_pdb
3IJ3

Yes

CBU_0572

29541173

cytosol aminopeptidase family protein [C...

458

Conserved; Drug target functions

Phase 3: June 2008

3IJ3

100%

Coxiella burnetii

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02208
(show subtarget assignments)

1

cloned

No

FTT0964c

56708058

ffh

signal recognition particle protein, Ffh...

458

Conserved; Drug target functions

Phase 3: June 2008

2XXA

59%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP02648
(show subtarget assignments)

1

soluble

No

FTT0064

56707243

atpD

F0F1 ATP synthase subunit beta [Francise...

458

Conserved; Drug target functions

Phase 3: June 2008

3OAA

81.3%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP05146
(show subtarget assignments)

1

cloned

No

BAS4784

49187774

-

glycyl-tRNA synthetase [Bacillus anthrac...

458

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1ATI

43.2%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP02155
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0239

16120577

trkA

potassium transporter peripheral membran...

458

Conserved; CD; Drug target functions

Phase 3: June 2008

1LSS

12.2%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP91398
(show subtarget assignments)

8

soluble

No

VV1_1045

27364477

trkA

potassium transporter peripheral membran...

458

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3L4B

12.7%

Vibrio vulnificus

IDP04438
(show subtarget assignments)

1

expressed

No

YPO0073

115345903

cpxA

two component sensor kinase [Yersinia pe...

458

conserved gene; putative drug target function;

Phase 4: April 2009

2C2A

16.8%

Yersinia pestis

Regulatory functions

Other

IDP00537
(show subtarget assignments)

1

purified

No

YPO3924

16124055

argH

argininosuccinate lyase

457

Conserved Gene / Pathway

Phase 2: March 2008

1TJ7

88.8%

Yersinia pestis

Amino acid biosynthesis

Glutamate family

IDP91293
(show subtarget assignments)

8

soluble

No

SPA3343

56415395

cysG

siroheme synthase [Salmonella enterica s...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

99.6%

Salmonella enterica

IDP91226
(show subtarget assignments)

8

soluble

No

NT04EC4239

26110396

cysG

Siroheme synthase [Escherichia coli CFT0...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

90.2%

Escherichia coli

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91222
(show subtarget assignments)

8

soluble

No

SF3387

24114633

cysG

siroheme synthase [Shigella flexneri 2a ...

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

90.2%

Shigella flexneri

IDP91305
(show subtarget assignments)

8

soluble

No

STM3477

16766765

cysG

siroheme synthase

457

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

99.8%

Salmonella enterica

IDP00356
(show subtarget assignments)

1

purified

No

lmo0198

16802244

gcaD

hypothetical protein lmo0198

457

Predicted involvement in glycosyl group metabolism; Drug Target Homologs

Phase 2: March 2008

1HM0

54.3%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04397
(show subtarget assignments)

1

expressed

No

GBAA3230

47528520

sensor histidine kinase [Bacillus anthra...

457

putative drug target function;

Phase 4: April 2009

2C2A

17.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP00624
(show subtarget assignments)

8

in_pdb
3T41
3QFH

No

SACOL1874

57284795

epiP

epidermin leader peptide processing seri...

457

Drug Target Function

Community Requests

3QFH

94.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP05742
(show subtarget assignments)

1

cloned

No

CD2655

126700269

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

457

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1GG4

31.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04373
(show subtarget assignments)

1

cloned

No

YPO3097

218930139

manB

phosphomannomutase [Yersinia pestis CO92...

457

drug target; virulence factor; putative drug target function;

Phase 4: April 2009

3UW2

37.8%

Yersinia pestis

Energy metabolism

Sugars

IDP00476
(show subtarget assignments)

1

soluble

No

YPO0063

161486895

hypothetical protein YPO0063

456

Virulence Associated Factor

Phase 2: March 2008

1I84

13.4%

Yersinia pestis

Cell envelope

Other

IDP01807
(show subtarget assignments)

1

cloned

No

FTT0873c

56707977

radA

DNA repair protein RadA [Francisella tul...

456

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3K1J

15.1%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP00467
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1974

16122218

N-formimino-L-glutamate deiminase

456

Conserved Gene / Pathway

Phase 2: March 2008

3MDU

59.2%

Yersinia pestis

Cellular processes

Detoxification

IDP02269
(show subtarget assignments)

1

cloned

No

Cj0608

15791968

outer membrane efflux protein [Campyloba...

456

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

3PIK

23.7%

Campylobacter jejuni

Protein fate

Protein folding and stabilization

IDP00427
(show subtarget assignments)

1

in_pdb
3FWW

No

YPO4119

16124227

glmU

bifunctional N-acetylglucosamine-1-phosp...

456

Drug Target Function

Phase 2: March 2008

3FWW

100%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02814
(show subtarget assignments)

1

cloned

No

FTT0709

56707828

eno

enolase (2-phosphoglycerate dehydratase)...

456

Conserved; Drug target functions

Phase 3: June 2008

1IYX

60.5%

Francisella tularensis

Energy metabolism

Glycolysis/gluconeogenesis

IDP05637
(show subtarget assignments)

1

cloned

No

CD2518

126700135

cell surface protein [Clostridium diffic...

456

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP01387
(show subtarget assignments)

1

cloned

No

VC0566

15640588

protease DO

456

Drug Target Function

Phase 2: March 2008

2ZLE

57.7%

Vibrio cholerae

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02373
(show subtarget assignments)

1

expressed

No

FTT0438

56707582

mpl

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

456

Conserved; Drug target functions

Phase 3: June 2008

3HN7

41.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00582
(show subtarget assignments)

1

in_pdb
3GSE

Yes

YPO2528

16122747

menF

menaquinone-specific isochorismate synth...

455

Conserved Gene / Pathway

Phase 2: March 2008

3GSE

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Menaquinone and ubiquinone

IDP02087
(show subtarget assignments)

1

in_crystallization_trials

No

STM3348

16766643

degQ

serine endoprotease [Salmonella typhimur...

455

Drug target motif; Conserved; Drug target functions

Phase 3: June 2008

4A8A

84.4%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP01041
(show subtarget assignments)

1

purified

No

STM2971

16766276

sdaB

L-serine dehydratase/L-threonine deamina...

455

Conserved Gene / Pathway

Phase 2: March 2008

2IQQ

16%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP05203
(show subtarget assignments)

1

cloned

No

CD1708

126699315

hypothetical protein CD1708 [Clostridium...

455

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP02698
(show subtarget assignments)

1

purified

No

FTT0387

56707536

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

3FWW

51%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05411
(show subtarget assignments)

1

purified

No

BA_2793

30257397

putative chitin binding protein [Bacillu...

455

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2XWX

21.3%

Bacillus anthracis

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP01620
(show subtarget assignments)

1

cloned

No

FTT0687c

56707807

hslU

ATP-dependent protease ATP-binding subun...

455

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1DO0

64.6%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP91584
(show subtarget assignments)

8

expressed

No

CBU_0425

29541034

hypothetical protein

455

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Coxiella burnetii

IDP00741
(show subtarget assignments)

1

purified

No

SACOL1253

57285992

ffh

signal recognition particle protein

455

Drug Target Function

Phase 2: March 2008

2XXA

49.5%

Staphylococcus aureus

Protein fate

Protein and peptide secretion and trafficking

IDP00318
(show subtarget assignments)

1

cloned

No

CBU_1947

29655231

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Drug Target Function

Phase 2: March 2008

1HV9

51.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04527
(show subtarget assignments)

1

cloned

No

STM1824_1_454

16765165

pabB

para-aminobenzoate synthase component I ...

454

Salmonella essential protein

Phase 4: April 2009

1K0E

76.2%

Salmonella enterica

IDP02466
(show subtarget assignments)

1

crystallized

No

YPO1771

16122025

L-serine dehydratase [Yersinia pestis CO...

454

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Involved in vir...

Phase 3: June 2008

2IQQ

17%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP05130
(show subtarget assignments)

1

cloned

No

CD0119

126697691

phosphoglucomutase/phosphomannomutase mu...

454

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3PDK

50.2%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP00350
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1633

16803673

trpE

anthranilate synthase component I

454

Drug Target Function

Phase 2: March 2008

1QDL

35.7%

Listeria monocytogenes

Amino acid biosynthesis

Aromatic amino acid family

IDP02716
(show subtarget assignments)

1

cloned

No

GBAA0325

47525592

gabT

4-aminobutyrate aminotransferase [Bacill...

454

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1SF2

45.2%

Bacillus anthracis

Central intermediary metabolism

Other

IDP05738
(show subtarget assignments)

1

cloned

No

CD2090

126699707

putative xanthine/uracile permease [Clos...

453

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3QE7

28%

Clostridium difficile

Transport and binding proteins: Nucleosides, purines and pyrimidines

IDP01871
(show subtarget assignments)

1

cloned

No

FTT1795c

56708783

trpC

bifunctional indole-3-glycerol phosphate...

453

Conserved; Drug target functions

Phase 3: June 2008

1PII

56.1%

Francisella tularensis

Amino acid biosynthesisFatty acid and phospholipid metabolism

Aromatic amino acid familyHistidine family,Biosynthesis

IDP02152
(show subtarget assignments)

1

soluble

No

FTT0955c

56708049

gor

glutathione reductase [Francisella tular...

453

Conserved; Drug target functions

Phase 3: June 2008

1GER

49.2%

Francisella tularensis

Energy metabolism

Electron transport

IDP91736
(show subtarget assignments)

8

selected

No

Q51451_PSEAE

0

453

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1R4T

30.7%

Pseudomonas aeruginosa

IDP91999
(show subtarget assignments)

8

selected

No

SpneCM_010100004482

298254857

BlpC ABC transporter [Streptococcus pneu...

453

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP04627
(show subtarget assignments)

8

cloned

No

BAS5321

49188305

replicative DNA helicase [Bacillus anthr...

453

Proposed to be essential proteins

Community Requests

2VYE

75.3%

Bacillus anthracis

IDP91308
(show subtarget assignments)

8

soluble

No

VV2_0483

27366917

membrane-fusion protein [Vibrio vulnific...

453

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91748
(show subtarget assignments)

8

selected

No

Q933J5_PSEAE

0

453

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1R4T

30.5%

Pseudomonas aeruginosa

IDP01477
(show subtarget assignments)

1

purified

No

VC2762

15642755

glmU

bifunctional N-acetylglucosamine-1-phosp...

453

Drug Target Function

Phase 2: March 2008

1HV9

67.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01455
(show subtarget assignments)

1

purified

No

VC2405

15642402

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

453

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

52.5%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90744
(show subtarget assignments)

8

expressed

No

Cj1059c

15792386

gatA

aspartyl/glutamyl-tRNA amidotransferase ...

453

Predicted Essential

Community Requests

3H0L

47.9%

Campylobacter jejuni

IDP91566
(show subtarget assignments)

8

cloned

No

BAB34991

13361032

ECs1568

hypothetical protein [Escherichia coli O...

453

virulence/pathogenesis / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Escherichia coli

IDP04272
(show subtarget assignments)

1

expressed

No

GBAA3899

47529188

lantibiotic biosynthesis sensor histidin...

453

putative drug target function;

Phase 4: April 2009

2C2A

14.3%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP90901
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3273

16123430

pssA

phosphatidylserine synthase [Yersinia pe...

452

Predicted Essential

Community Requests

3HSI

50.3%

Yersinia pestis

IDP00904
(show subtarget assignments)

0

work_stopped

No

STM0124

16763514

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

1GG4

87.6%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02368
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0422

56707569

murF

UDP-N--acetylmuramoylalanyl-D-glutamyl-2...

452

Conserved; Drug target functions

Phase 3: June 2008

1GG4

33.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04076
(show subtarget assignments)

1

expressed

No

GBAA2213

47527506

sensor histidine kinase [Bacillus anthra...

452

putative drug target function;

Phase 4: April 2009

2C2A

18.6%

Bacillus anthracis

Regulatory functions

Protein interactions

IDP00689
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2073

57284941

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

2AM1

33.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05762
(show subtarget assignments)

1

soluble

No

lmo2119

16804158

-

hypothetical protein lmo2119 [Listeria m...

453

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KXY

7.1%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP02309
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0239

56707396

murC

UDP-N-acetylmuramate--alanine ligase [Fr...

451

Conserved; Drug target functions

Phase 3: June 2008

2F00

36.1%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05294
(show subtarget assignments)

1

cloned

No

CD1418

126699021

putative drug/sodium antiporter [Clostri...

451

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

3MKT

20.6%

Clostridium difficile

Transport and binding proteins: Other

IDP00196
(show subtarget assignments)

1

cloned

No

YPO1051

16121351

-

putative membrane protein

451

Virulence

Phase 1: October 2007

2ZPL

13.5%

Yersinia pestis

IDP91415
(show subtarget assignments)

8

cloned

No

VV1_0698

27364154

Mg/Co/Ni transporter MgtE [Vibrio vulnif...

451

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2YVX

29%

Vibrio vulnificus

IDP05743
(show subtarget assignments)

1

cloned

No

CD2653

126700267

murD

UDP-N-acetylmuramoylalanine--D-glutamate...

451

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3LK7

38.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01466
(show subtarget assignments)

1

in_crystallization_trials

No

VC2542

15642537

UDP-N-acetylmuramate:L-alanyl-gamma-D-gl...

451

Conserved Gene / Pathway

Phase 2: March 2008

3HN7

51%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04711
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0513

115346323

conserved hypothetical protein [Yersinia...

451

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP00694
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2151

57286365

glmM

phosphoglucosamine mutase GlmM

451

Drug Target Function

Phase 2: March 2008

3PDK

67.4%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00111
(show subtarget assignments)

1

in_pdb
3TV9

No

NT02SF4808

30043741

pmbA

putative peptide maturation protein

450

Virulence

Phase 1: October 2007

3TV9

96.2%

Shigella flexneri

Cellular processes

Toxin production and resistance

IDP04725
(show subtarget assignments)

1

selected

No

YPO1467

115347221

conserved hypothetical protein [Yersinia...

450

virulence factor;

Phase 4: April 2009

Yersinia pestis

Hypothetical proteins

Conserved

IDP00204
(show subtarget assignments)

1

expressed

No

YPO1702

16121962

-

putative membrane protein

450

Virulence

Phase 1: October 2007

Yersinia pestis

Hypothetical proteins

Conserved

IDP02748
(show subtarget assignments)

1

expressed

No

GBAA4408

47529702

accC

acetyl-CoA carboxylase biotin carboxylas...

450

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

2VPQ

66.4%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP04649
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1283

56708343

trmE

tRNA modification GTPase TrmE [Francisel...

450

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XZP

36.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP01650
(show subtarget assignments)

1

in_pdb
3IFS

No

GBAA5130

47530435

pgi

glucose-6-phosphate isomerase [Bacillus ...

450

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3IFS

100%

Bacillus anthracis

Energy metabolism

Glycolysis/gluconeogenesis

IDP05036
(show subtarget assignments)

1

cloned

No

BA_1663

30255960

hypothetical protein BA_1663 [Bacillus a...

450

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

IDP05546
(show subtarget assignments)

1

cloned

No

lmo0054

16802102

dnaC

replicative DNA helicase [Listeria monoc...

450

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 5: 2010

2R6A

77.1%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP05161
(show subtarget assignments)

1

cloned

No

BA_1671

30255967

putative flagellar hook-associated FliD ...

450

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cellular processes: Chemotaxis and motility

IDP00656
(show subtarget assignments)

1

cloned

No

SACOL0543

57284226

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

450

Drug Target Function

Phase 2: March 2008

1G95

49.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides