Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05107 (show subtarget assignments)	1	soluble	No	CD1751	126699358		cell surface protein (putative cell surf...	795	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1VSN	8.4%	Clostridium difficile	Cell envelope: Other

IDP02565 (show subtarget assignments)	1	soluble	No	CBU_0648	29541249	ribH	6,7-dimethyl-8-ribityllumazine synthase ...	151	Conserved; Drug target functions	Phase 3: June 2008	1VSW	47.7%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP02735 (show subtarget assignments)	1	purified	No	GBAA4334	47529631	ribH	riboflavin synthase subunit beta [Bacill...	153	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VSW	100%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP04405 (show subtarget assignments)	1	cloned	No	CPF_2987	110799346		stage 0 sporulation protein J [Clostridi...	286	conserved gene; putative drug target function;	Phase 4: April 2009	1VZ0	33.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP01887 (show subtarget assignments)	1	expressed	No	GBAA5729	47531065	spo0J	stage 0 sporulation protein J [Bacillus ...	256	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	36.3%	Bacillus anthracis	Cellular processes	Sporulation and germination

IDP01811 (show subtarget assignments)	1	expressed	No	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP00837 (show subtarget assignments)	1	purified	No	SACOL2735	57285289		chromosome partioning protein, ParB fami...	279	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	31.2%	Staphylococcus aureus	Cellular processes	Cell division

IDP01478 (show subtarget assignments)	1	purified	No	VC2772	15642765		ParB family protein	293	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	33.8%	Vibrio cholerae	Cellular processes	Cell division

IDP01917 (show subtarget assignments)	1	soluble	No	GBAA1429	47526701	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	239	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VZW	36.5%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP05264 (show subtarget assignments)	1	expressed	No	CD3257	126700876		putative polysaccharide deacetylase [Clo...	275	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1W17	25.5%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00797 (show subtarget assignments)	1	expressed	No	SACOL1250	57285989		chromosome segregation SMC protein, puta...	1188	Conserved Gene / Pathway	Phase 2: March 2008	1W1W	7.5%	Staphylococcus aureus	Cellular processes	Cell division

IDP02270 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1424	29541984	hemB	porphobilinogen synthase [Coxiella burne...	334	Conserved; Drug target functions	Phase 3: June 2008	1W1Z	48.8%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP02395 (show subtarget assignments)	1	expressed	No	GBAA3321	161611191	serC	phosphoserine aminotransferase [Bacillus...	324	Conserved; Drug target functions	Phase 3: June 2008	1W23	50%	Bacillus anthracis	Amino acid biosynthesis	Serine family

IDP02141 (show subtarget assignments)	1	purified	No	CBU_0737	29541337	tig	trigger factor [Coxiella burnetii RSA 49...	442	Conserved; Drug target functions	Phase 3: June 2008	1W26	41%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP02054 (show subtarget assignments)	1	purified	No	FTT0623	56707748	tig	trigger factor [Francisella tularensis s...	438	Conserved; Drug target functions	Phase 3: June 2008	1W26	40.4%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP00634 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1722	57284733	tig	trigger factor	433	Drug Target Function	Phase 2: March 2008	1W26	31.6%	Staphylococcus aureus	Protein fate	Protein folding and stabilization

IDP04218 (show subtarget assignments)	1	expressed	No	STM2996_1_1123	16766298	recC	exonuclease V subunit gamma [Salmonella ...	1123	Salmonella essential protein	Phase 4: April 2009	1W36	88.4%	Salmonella enterica

IDP00326 (show subtarget assignments)	0	work_stopped	No	Cj1607	15792912	ispDF	bifunctional 2-C-methyl-D-erythritol 4-p...	371	Drug Target Function	Phase 2: March 2008	1W55	100%	Campylobacter jejuni	Amino acid biosynthesis	Histidine family

IDP05537 (show subtarget assignments)	1	cloned	No	CD3419	126701042	hemB	delta-aminolevulinic acid dehydratase [C...	321	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1W5Q	55.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02564 (show subtarget assignments)	1	purified	No	GBAA0084	47525340	ispD	2-C-methyl-D-erythritol 4-phosphate cyti...	226	Conserved; Drug target functions	Phase 3: June 2008	1W77	36.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP04637 (show subtarget assignments)	1	cloned	No	FTT0371c	56707522	folC	FolC bifunctional protein [Francisella t...	393	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1W78	29.8%	Francisella tularensis

IDP02171 (show subtarget assignments)	1	soluble	No	CBU_0894	29541483	folC	FolC bifunctional protein [Coxiella burn...	416	Conserved; Drug target functions	Phase 3: June 2008	1W78	42.5%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP90776 (show subtarget assignments)	8	purified	No	STM2365	16765692	folC	bifunctional folylpolyglutamate synthase...	422	Predicted Essential	Community Requests	1W78	86.7%	Salmonella enterica

IDP02425 (show subtarget assignments)	1	soluble	No	GBAA2775	47528067	acoB	TPP-dependent acetoin dehydrogenase E1 b...	344	Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1W85	43.9%	Bacillus anthracis	Energy metabolism	Fermentation

IDP04284 (show subtarget assignments)	1	cloned	No	YPO0808	218927988		general secretion pathway protein L [Yer...	389	putative drug target function;	Phase 4: April 2009	1W97	13.1%	Yersinia pestis	Protein fate	Protein and peptide secretion and trafficking

IDP05143 (show subtarget assignments)	1	cloned	No	BAS4423	49187418	-	triple helix repeat-containing collagen ...	312	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1WCK	27.6%	Bacillus anthracis	Unknown function: General

IDP00458 (show subtarget assignments)	1	in_crystallization_trials	No	YPO2680	16122885	celC	N,N'-diacetylchitobiose-specific PTS sys...	115	Conserved Gene / Pathway	Phase 2: March 2008	1WCR	67%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01307 (show subtarget assignments)	1	soluble	No	VC1283	15641296		PTS system, cellobiose-specific IIA comp...	111	Conserved Gene / Pathway	Phase 2: March 2008	1WCR	45.9%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01888 (show subtarget assignments)	1	cloned	No	GBAA5730	47531066	soJ	sporulation initiation inhibitor protein...	253	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WCV	48.6%	Bacillus anthracis	Regulatory functions	Other

IDP01443 (show subtarget assignments)	1	soluble	No	VC2061	15642061		ParA family protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1WCV	34.1%	Vibrio cholerae	Cellular processes	Cell division

IDP04519 (show subtarget assignments)	1	cloned	No	CPF_2988	110798938	soj	sporulation initiation inhibitor protein...	257	conserved gene; putative drug target function;	Phase 4: April 2009	1WCV	43.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP02583 (show subtarget assignments)	1	soluble	No	GBAA5249	47530554		3-hydroxyacyl-CoA dehydrogenase/enoyl-Co...	793	Conserved; Drug target functions	Phase 3: June 2008	1WDK	14.6%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Degradation

IDP00545 (show subtarget assignments)	1	cloned	No	YPO2747	16122951	fadJ	multifunctional fatty acid oxidation com...	774	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	34.1%	Yersinia pestis	Cellular processes	Detoxification

IDP00503 (show subtarget assignments)	1	purified	No	YPO3766	16123902	fadB	multifunctional fatty acid oxidation com...	729	Virulence Associated Factor	Phase 2: March 2008	1WDK	55.1%	Yersinia pestis	Cellular processes	Detoxification

IDP00999 (show subtarget assignments)	1	expressed	No	STM2388	16765715	fadJ	multifunctional fatty acid oxidation com...	715	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	35.8%	Salmonella enterica	Fatty acid and phospholipid metabolism	Degradation

IDP04410 (show subtarget assignments)	1	cloned	No	VC1047	9655512		fatty oxidation complex, alpha subunit [...	724	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1WDK	36.4%	Vibrio cholerae	Fatty acid and phospholipid metabolism	Degradation

IDP01184 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0267	41016866		60 kDa chaperonin (Protein Cpn60) (groEL...	544	Conserved Gene / Pathway	Phase 2: March 2008	1WE3	67.1%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP05529 (show subtarget assignments)	1	cloned	No	CD2658	126700272	mraW	S-adenosyl-methyltransferase [Clostridiu...	318	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1WG8	41.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02514 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_0116	29540736	mraW	S-adenosyl-methyltransferase MraW [Coxie...	307	Conserved; Drug target functions	Phase 3: June 2008	1WG8	46.9%	Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP91713 (show subtarget assignments)	8	selected	No	NP_006668	57529246	USP19	ubiquitin carboxyl-terminal hydrolase 19...	1318	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1WH0	9.3%	Homo sapiens

IDP01647 (show subtarget assignments)	1	expressed	No	CBU_0795	29541389	folE	GTP cyclohydrolase I [Coxiella burnetii ...	184	Conserved; Drug target functions	Phase 3: June 2008	1WM9	56%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP00207 (show subtarget assignments)	1	soluble	No	YPO1950	16122196	-	putative peptidase	405	Virulence	Phase 1: October 2007	1WN1	23.7%	Yersinia pestis	Hypothetical proteins	Conserved

IDP00969 (show subtarget assignments)	1	purified	No	STM1597	161353598	ydcW	putative aldehyde dehydrogenase	474	Conserved Gene / Pathway	Phase 2: March 2008	1WNB	83.5%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP01183 (show subtarget assignments)	1	purified	No	BA_0266	60389755		10 kDa chaperonin (Protein Cpn10) (groES...	94	Conserved Gene / Pathway	Phase 2: March 2008	1WNR	66%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP04671 (show subtarget assignments)	1	soluble	No	GBAA1416	47526688	ilvE-1	branched-chain amino acid aminotransfera...	298	conserved gene; putative drug target function;	Phase 4: April 2009	1WRV	40.3%	Bacillus anthracis	Amino acid biosynthesis	Pyruvate family

IDP91645 (show subtarget assignments)	8	soluble	No	NP_215862	15608486		acyl-CoA dehydrogenase [Mycobacterium tu...	386	virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...	Community Requests	1WS9	27.2%	Mycobacterium tuberculosis

IDP91816 (show subtarget assignments)	8	cloned	No	b2463	1788806	maeB	fused malic enzyme predicted oxidoreduct...	759	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1WW8	26.5%	Escherichia coli

IDP05096 (show subtarget assignments)	1	cloned	No	CD0015	126697581		putative cytosine/adenosine deaminase [C...	155	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1WWR	48.1%	Clostridium difficile	Transport and binding proteins: Unknown substrate

IDP91203 (show subtarget assignments)	8	cloned	No	BLD_0429	189439292	aroE	Shikimate 5-dehydrogenase [Bifidobacteri...	323	potential drug target / Shikimate pathway enzyme	Community Requests	1WXD	26%	Bifidobacterium longum

IDP04414 (show subtarget assignments)	8	selected	No	CAC05786	12329055	sepA	SepA, extracellular serine protease of t...	1364	Shigella effector protein	Community Requests	1WXR	34.9%	Shigella flexneri

IDP02830 (show subtarget assignments)	1	soluble	No	GBAA4861	47530155	pepQ-2	proline dipeptidase [Bacillus anthracis ...	365	Drug target motif; Involved in sporulation; Drug target functions	Phase 3: June 2008	1WY2	38.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00681 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1756	57286191	pepQ	proline dipeptidase	351	Drug Target Function	Phase 2: March 2008	1WY2	41.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05595 (show subtarget assignments)	1	soluble	No	BA_3346	30257889		putative 6-aminohexanoate-dimer hydrolas...	419	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1WYB	26.3%	Bacillus anthracis	Central intermediary metabolism: Other

IDP04450 (show subtarget assignments)	1	cloned	No	YPO0905	218928078	gcvP	glycine dehydrogenase [Yersinia pestis C...	959	conserved gene; putative drug target function;	Phase 4: April 2009	1WYT	19.1%	Yersinia pestis	Energy metabolism	Amino acids and amines

IDP90673 (show subtarget assignments)	8	expressed	No	VC1833	15641835		quinolinate synthetase [Vibrio cholerae ...	353	Predicted Essential	Community Requests	1WZU	30.6%	Vibrio cholerae

IDP92082 (show subtarget assignments)	8	selected	No	TGME49_107570	237845455		glycerol-3-phosphate dehydrogenase, puta...	401	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1X0V	42.4%	Toxoplasma gondii

IDP05064 (show subtarget assignments)	1	cloned	No	CD2370	126699985	nadC	nicotinate-nucleotide pyrophosphorylase ...	270	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1X1O	46.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04688 (show subtarget assignments)	1	soluble	No	GBAA4661	47529959	nadC	nicotinate-nucleotide pyrophosphorylase ...	277	putative drug target function;	Phase 4: April 2009	1X1O	43.7%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01813 (show subtarget assignments)	1	purified	No	GBAA1253	47526519	trpB	tryptophan synthase subunit beta [Bacill...	397	Conserved; Drug target functions	Phase 3: June 2008	1X1Q	63%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00082 (show subtarget assignments)	0	work_stopped	No	NTL01ST4427	16423142	lplA	lipoate-protein ligase A	338		Phase 1: October 2007	1X2G	93.2%	Salmonella enterica	Cell envelope	Other

IDP90215 (show subtarget assignments)	8	expressed	No	MYXV_gp009	9633800	m006L	m006L, m6	509	contains kelch motifs, similar to MYX-L-m006R	Community Requests	1X2J	13.9%	Myxoma virus	unknown	0

IDP90531 (show subtarget assignments)	8	cloned	No	Q9KSF9	20139940		RecName: Full=Asparaginyl-tRNA synthetas...	466	Predicted Essential	Community Requests	1X54	35.2%	Vibrio cholerae

IDP05209 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1494	57650409	asnC	asparaginyl-tRNA synthetase [Staphylococ...	430	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	45.8%	Staphylococcus aureus	Protein synthesis: tRNA aminoacylation

IDP90728 (show subtarget assignments)	8	cloned	No	YPO1412	16121692	asnC	asparaginyl-tRNA synthetase [Yersinia pe...	466	Predicted Essential	Community Requests	1X54	34.3%	Yersinia pestis

IDP05239 (show subtarget assignments)	1	cloned	No	lmo1896	16803935	ansB	asparaginyl-tRNA synthetase [Listeria mo...	430	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	45.3%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05569 (show subtarget assignments)	1	soluble	No	BAS4454	49187449	-	asparaginyl-tRNA synthetase [Bacillus an...	463	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1X54	35.9%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP91714 (show subtarget assignments)	8	selected	No	NP_006734	5803137	RBM3	putative RNA-binding protein 3 [Homo sap...	157	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1X5S	41.4%	Homo sapiens

IDP91808 (show subtarget assignments)	8	selected	No	AAB07788	924760	CTCF	CTCF [Homo sapiens]	727	innate immunity / CTCF (CCCTC-binding factor) is an evolutionarily-conserved transcription factor ...	Community Requests	1X6H	10.2%	Homo sapiens

IDP02658 (show subtarget assignments)	1	cloned	No	STM2648	16765968	yfiF	putative methyltransferase [Salmonella t...	345	Conserved; Essential; Drug target functions	Phase 3: June 2008	1X7O	20.6%	Salmonella enterica	Unknown function	General

IDP90999 (show subtarget assignments)	8	cloned	No	y1744	22125639		hypothetical protein y1744 [Yersinia pes...	95	other biological interest / -	Community Requests	1X7V	33.7%	Yersinia pestis

IDP00009 (show subtarget assignments)	1	soluble	No	BA_1538	38372188		3-dehydroquinate synthase	363	Drug Target Homolog	Phase 1: October 2007	1XAG	38.3%	Bacillus anthracis	Amino acid biosynthesis	Aromatic amino acid family

IDP00638 (show subtarget assignments)	1	purified	No	SACOL2736	57285290	gidB	glucose-inhibited division protein B	239	Drug Target Function	Phase 2: March 2008	1XDZ	63.2%	Staphylococcus aureus	Unknown function	General

IDP91512 (show subtarget assignments)	8	cloned	No	VV2_0404	27366843		cytolysin [Vibrio vulnificus CMCP6]	468	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XEZ	25.9%	Vibrio vulnificus

IDP01348 (show subtarget assignments)	0	work_stopped	No	VCA0219	15600988		haemolysin	741	Conserved Gene / Pathway	Phase 2: March 2008	1XEZ	94.7%	Vibrio cholerae	Cellular processes	Pathogenesis

IDP90537 (show subtarget assignments)	8	purified	No	Q9KL24	21542209		RecName: Full=Dihydroorotase; Short=DHOa...	342	Predicted Essential	Community Requests	1XGE	55%	Vibrio cholerae

IDP01857 (show subtarget assignments)	1	soluble	No	FTT1034c	56708121	ndh	NADH dehydrogenase [Francisella tularens...	420	Drug Target	Phase 3: June 2008	1XHC	21%	Francisella tularensis	Energy metabolism	Electron transport

IDP00081 (show subtarget assignments)	1	in_crystallization_trials	No	NT01ST5473	16422973	ytfP	putative cytoplasmic protein	114	Essential	Phase 1: October 2007	1XHS	92.1%	Salmonella enterica	Unknown function	General

IDP05512 (show subtarget assignments)	1	cloned	No	CD1601	126699205	thiE1	thiamine-phosphate pyrophosphorylase [Cl...	210	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XI3	41%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP04167 (show subtarget assignments)	1	cloned	No	VC1977	9656518		aspartate aminotransferase, putative [Vi...	404	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XI9	40.8%	Vibrio cholerae	Amino acid biosynthesis	Aspartate family

IDP91487 (show subtarget assignments)	8	soluble	No	VP1697	28898471		putative type III export apparatus prote...	142	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XKP	20.4%	Vibrio parahaemolyticus

IDP91507 (show subtarget assignments)	8	expressed	No	VP1667	28898441		putative outer membrane protein PopN [Vi...	297	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XKP	29.3%	Vibrio parahaemolyticus

IDP91509 (show subtarget assignments)	8	soluble	No	VP1665	28898439		putative type III secretion protein [Vib...	123	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XKP	35.8%	Vibrio parahaemolyticus

IDP91508 (show subtarget assignments)	8	cloned	No	VP1666	28898440		hypothetical protein VP1666 [Vibrio para...	94	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1XL3	44.7%	Vibrio parahaemolyticus

IDP02191 (show subtarget assignments)	1	expressed	No	FTT0878c	56707982	msrB	methionine sulfoxide reductase B [Franci...	170	Drug Target	Phase 3: June 2008	1XM0	47.6%	Francisella tularensis	Cell envelopeProtein fate	Surface structuresProtein modification and repair

IDP04018 (show subtarget assignments)	1	cloned	No	CPF_1860	110799668	msrB	methionine sulfoxide reductase B [Clostr...	147	conserved gene; putative drug target function;	Phase 4: April 2009	1XM0	64.6%	Clostridium perfringens	Cellular processes	Adaptations to atypical conditions

IDP05519 (show subtarget assignments)	1	cloned	No	CD1704	126699311	thiG	thiazole synthase [Clostridium difficile...	261	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XM3	47.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP01032 (show subtarget assignments)	1	soluble	No	STM3507	16766795	yhgG	putative cytoplasmic protein	78	Conserved Gene / Pathway	Phase 2: March 2008	1XN7	89.7%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP01392 (show subtarget assignments)	1	purified	No	VC0648	15640668		lipoprotein NlpI	303	Conserved Gene / Pathway	Phase 2: March 2008	1XNF	44.2%	Vibrio cholerae	Cell envelope	Other

IDP05031 (show subtarget assignments)	1	soluble	No	BA_0908	30254654		oligopeptide ABC transporter, oligopepti...	528	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	30.7%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05135 (show subtarget assignments)	1	soluble	No	CD0855	126698435	oppA	oligopeptide ABC transporter, substrate-...	522	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	33.1%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP04198 (show subtarget assignments)	1	soluble	No	CPF_2555	110799167		oligopeptide/dipeptide ABC transporter, ...	580	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XOC	29.8%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP02198 (show subtarget assignments)	1	cloned	No	YPO1273	16121558		putative substrate-binding transport pro...	602	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1XOC	21.6%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP05074 (show subtarget assignments)	1	cloned	No	lmo0135	16802183	-	hypothetical protein lmo0135 [Listeria m...	524	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	32.4%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP01206 (show subtarget assignments)	1	purified	No	BA_2446	30257076		N-acetylmuramoyl-L-alanine amidase, fami...	245	Conserved Gene / Pathway	Phase 2: March 2008	1XOV	26.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05345 (show subtarget assignments)	1	soluble	No	Z3383	12516442	pbpG	penicillin-binding protein 7 [Escherichi...	313	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1XP4	25.9%	Escherichia coli	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01885 (show subtarget assignments)	1	cloned	No	GBAA5639	47530965		D-alanyl-D-alanine carboxypeptidase, put...	423	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01881 (show subtarget assignments)	1	cloned	No	GBAA0009	47525265	dacA	D-alanyl-D-alanine carboxypeptidase [Bac...	435	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	32.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02399 (show subtarget assignments)	1	cloned	No	GBAA2559	47527848		D-alanyl-D-alanine carboxypeptidase fami...	338	Drug target motif; Drug target functions	Phase 3: June 2008	1XP4	26.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01726 (show subtarget assignments)	1	cloned	No	GBAA5252	47530558		D-alanyl-D-alanine carboxypeptidase fami...	279	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1XP4	29.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92076 (show subtarget assignments)	8	selected	No	TGME49_097060	237843677		phosphoglycerate mutase 1, putative [Tox...	265	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1XQ9	70.2%	Toxoplasma gondii

IDP05107
(show subtarget assignments)

1

soluble

No

CD1751

126699358

cell surface protein (putative cell surf...

795

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1VSN

8.4%

Clostridium difficile

Cell envelope: Other

IDP02565
(show subtarget assignments)

1

soluble

No

CBU_0648

29541249

ribH

6,7-dimethyl-8-ribityllumazine synthase ...

151

Conserved; Drug target functions

Phase 3: June 2008

1VSW

47.7%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP02735
(show subtarget assignments)

1

purified

No

GBAA4334

47529631

ribH

riboflavin synthase subunit beta [Bacill...

153

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VSW

100%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP04405
(show subtarget assignments)

1

cloned

No

CPF_2987

110799346

stage 0 sporulation protein J [Clostridi...

286

conserved gene; putative drug target function;

Phase 4: April 2009

1VZ0

33.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP01887
(show subtarget assignments)

1

expressed

No

GBAA5729

47531065

spo0J

stage 0 sporulation protein J [Bacillus ...

256

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

36.3%

Bacillus anthracis

Cellular processes

Sporulation and germination

IDP01811
(show subtarget assignments)

1

expressed

No

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP00837
(show subtarget assignments)

1

purified

No

SACOL2735

57285289

chromosome partioning protein, ParB fami...

279

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

31.2%

Staphylococcus aureus

Cellular processes

Cell division

IDP01478
(show subtarget assignments)

1

purified

No

VC2772

15642765

ParB family protein

293

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

33.8%

Vibrio cholerae

Cellular processes

Cell division

IDP01917
(show subtarget assignments)

1

soluble

No

GBAA1429

47526701

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

239

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VZW

36.5%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP05264
(show subtarget assignments)

1

expressed

No

CD3257

126700876

putative polysaccharide deacetylase [Clo...

275

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1W17

25.5%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP00797
(show subtarget assignments)

1

expressed

No

SACOL1250

57285989

chromosome segregation SMC protein, puta...

1188

Conserved Gene / Pathway

Phase 2: March 2008

1W1W

7.5%

Staphylococcus aureus

Cellular processes

Cell division

IDP02270
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1424

29541984

hemB

porphobilinogen synthase [Coxiella burne...

334

Conserved; Drug target functions

Phase 3: June 2008

1W1Z

48.8%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP02395
(show subtarget assignments)

1

expressed

No

GBAA3321

161611191

serC

phosphoserine aminotransferase [Bacillus...

324

Conserved; Drug target functions

Phase 3: June 2008

1W23

50%

Bacillus anthracis

Amino acid biosynthesis

Serine family

IDP02141
(show subtarget assignments)

1

purified

No

CBU_0737

29541337

tig

trigger factor [Coxiella burnetii RSA 49...

442

Conserved; Drug target functions

Phase 3: June 2008

1W26

41%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP02054
(show subtarget assignments)

1

purified

No

FTT0623

56707748

tig

trigger factor [Francisella tularensis s...

438

Conserved; Drug target functions

Phase 3: June 2008

1W26

40.4%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP00634
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1722

57284733

tig

trigger factor

433

Drug Target Function

Phase 2: March 2008

1W26

31.6%

Staphylococcus aureus

Protein fate

Protein folding and stabilization

IDP04218
(show subtarget assignments)

1

expressed

No

STM2996_1_1123

16766298

recC

exonuclease V subunit gamma [Salmonella ...

1123

Salmonella essential protein

Phase 4: April 2009

1W36

88.4%

Salmonella enterica

IDP00326
(show subtarget assignments)

0

work_stopped

No

Cj1607

15792912

ispDF

bifunctional 2-C-methyl-D-erythritol 4-p...

371

Drug Target Function

Phase 2: March 2008

1W55

100%

Campylobacter jejuni

Amino acid biosynthesis

Histidine family

IDP05537
(show subtarget assignments)

1

cloned

No

CD3419

126701042

hemB

delta-aminolevulinic acid dehydratase [C...

321

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1W5Q

55.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP02564
(show subtarget assignments)

1

purified

No

GBAA0084

47525340

ispD

2-C-methyl-D-erythritol 4-phosphate cyti...

226

Conserved; Drug target functions

Phase 3: June 2008

1W77

36.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP04637
(show subtarget assignments)

1

cloned

No

FTT0371c

56707522

folC

FolC bifunctional protein [Francisella t...

393

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1W78

29.8%

Francisella tularensis

IDP02171
(show subtarget assignments)

1

soluble

No

CBU_0894

29541483

folC

FolC bifunctional protein [Coxiella burn...

416

Conserved; Drug target functions

Phase 3: June 2008

1W78

42.5%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP90776
(show subtarget assignments)

8

purified

No

STM2365

16765692

folC

bifunctional folylpolyglutamate synthase...

422

Predicted Essential

Community Requests

1W78

86.7%

Salmonella enterica

IDP02425
(show subtarget assignments)

1

soluble

No

GBAA2775

47528067

acoB

TPP-dependent acetoin dehydrogenase E1 b...

344

Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1W85

43.9%

Bacillus anthracis

Energy metabolism

Fermentation

IDP04284
(show subtarget assignments)

1

cloned

No

YPO0808

218927988

general secretion pathway protein L [Yer...

389

putative drug target function;

Phase 4: April 2009

1W97

13.1%

Yersinia pestis

Protein fate

Protein and peptide secretion and trafficking

IDP05143
(show subtarget assignments)

1

cloned

No

BAS4423

49187418

-

triple helix repeat-containing collagen ...

312

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1WCK

27.6%

Bacillus anthracis

Unknown function: General

IDP00458
(show subtarget assignments)

1

in_crystallization_trials

No

YPO2680

16122885

celC

N,N'-diacetylchitobiose-specific PTS sys...

115

Conserved Gene / Pathway

Phase 2: March 2008

1WCR

67%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01307
(show subtarget assignments)

1

soluble

No

VC1283

15641296

PTS system, cellobiose-specific IIA comp...

111

Conserved Gene / Pathway

Phase 2: March 2008

1WCR

45.9%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01888
(show subtarget assignments)

1

cloned

No

GBAA5730

47531066

soJ

sporulation initiation inhibitor protein...

253

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WCV

48.6%

Bacillus anthracis

Regulatory functions

Other

IDP01443
(show subtarget assignments)

1

soluble

No

VC2061

15642061

ParA family protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1WCV

34.1%

Vibrio cholerae

Cellular processes

Cell division

IDP04519
(show subtarget assignments)

1

cloned

No

CPF_2988

110798938

soj

sporulation initiation inhibitor protein...

257

conserved gene; putative drug target function;

Phase 4: April 2009

1WCV

43.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP02583
(show subtarget assignments)

1

soluble

No

GBAA5249

47530554

3-hydroxyacyl-CoA dehydrogenase/enoyl-Co...

793

Conserved; Drug target functions

Phase 3: June 2008

1WDK

14.6%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Degradation

IDP00545
(show subtarget assignments)

1

cloned

No

YPO2747

16122951

fadJ

multifunctional fatty acid oxidation com...

774

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

34.1%

Yersinia pestis

Cellular processes

Detoxification

IDP00503
(show subtarget assignments)

1

purified

No

YPO3766

16123902

fadB

multifunctional fatty acid oxidation com...

729

Virulence Associated Factor

Phase 2: March 2008

1WDK

55.1%

Yersinia pestis

Cellular processes

Detoxification

IDP00999
(show subtarget assignments)

1

expressed

No

STM2388

16765715

fadJ

multifunctional fatty acid oxidation com...

715

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

35.8%

Salmonella enterica

Fatty acid and phospholipid metabolism

Degradation

IDP04410
(show subtarget assignments)

1

cloned

No

VC1047

9655512

fatty oxidation complex, alpha subunit [...

724

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1WDK

36.4%

Vibrio cholerae

Fatty acid and phospholipid metabolism

Degradation

IDP01184
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0267

41016866

60 kDa chaperonin (Protein Cpn60) (groEL...

544

Conserved Gene / Pathway

Phase 2: March 2008

1WE3

67.1%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP05529
(show subtarget assignments)

1

cloned

No

CD2658

126700272

mraW

S-adenosyl-methyltransferase [Clostridiu...

318

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1WG8

41.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02514
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_0116

29540736

mraW

S-adenosyl-methyltransferase MraW [Coxie...

307

Conserved; Drug target functions

Phase 3: June 2008

1WG8

46.9%

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP91713
(show subtarget assignments)

8

selected

No

NP_006668

57529246

USP19

ubiquitin carboxyl-terminal hydrolase 19...

1318

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1WH0

9.3%

Homo sapiens

IDP01647
(show subtarget assignments)

1

expressed

No

CBU_0795

29541389

folE

GTP cyclohydrolase I [Coxiella burnetii ...

184

Conserved; Drug target functions

Phase 3: June 2008

1WM9

56%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP00207
(show subtarget assignments)

1

soluble

No

YPO1950

16122196

-

putative peptidase

405

Virulence

Phase 1: October 2007

1WN1

23.7%

Yersinia pestis

Hypothetical proteins

Conserved

IDP00969
(show subtarget assignments)

1

purified

No

STM1597

161353598

ydcW

putative aldehyde dehydrogenase

474

Conserved Gene / Pathway

Phase 2: March 2008

1WNB

83.5%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP01183
(show subtarget assignments)

1

purified

No

BA_0266

60389755

10 kDa chaperonin (Protein Cpn10) (groES...

94

Conserved Gene / Pathway

Phase 2: March 2008

1WNR

66%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP04671
(show subtarget assignments)

1

soluble

No

GBAA1416

47526688

ilvE-1

branched-chain amino acid aminotransfera...

298

conserved gene; putative drug target function;

Phase 4: April 2009

1WRV

40.3%

Bacillus anthracis

Amino acid biosynthesis

Pyruvate family

IDP91645
(show subtarget assignments)

8

soluble

No

NP_215862

15608486

acyl-CoA dehydrogenase [Mycobacterium tu...

386

virulence/pathogenesis / All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...

Community Requests

1WS9

27.2%

Mycobacterium tuberculosis

IDP91816
(show subtarget assignments)

8

cloned

No

b2463

1788806

maeB

fused malic enzyme predicted oxidoreduct...

759

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1WW8

26.5%

Escherichia coli

IDP05096
(show subtarget assignments)

1

cloned

No

CD0015

126697581

putative cytosine/adenosine deaminase [C...

155

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1WWR

48.1%

Clostridium difficile

Transport and binding proteins: Unknown substrate

IDP91203
(show subtarget assignments)

8

cloned

No

BLD_0429

189439292

aroE

Shikimate 5-dehydrogenase [Bifidobacteri...

323

potential drug target / Shikimate pathway enzyme

Community Requests

1WXD

26%

Bifidobacterium longum

IDP04414
(show subtarget assignments)

8

selected

No

CAC05786

12329055

sepA

SepA, extracellular serine protease of t...

1364

Shigella effector protein

Community Requests

1WXR

34.9%

Shigella flexneri

IDP02830
(show subtarget assignments)

1

soluble

No

GBAA4861

47530155

pepQ-2

proline dipeptidase [Bacillus anthracis ...

365

Drug target motif; Involved in sporulation; Drug target functions

Phase 3: June 2008

1WY2

38.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00681
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1756

57286191

pepQ

proline dipeptidase

351

Drug Target Function

Phase 2: March 2008

1WY2

41.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05595
(show subtarget assignments)

1

soluble

No

BA_3346

30257889

putative 6-aminohexanoate-dimer hydrolas...

419

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1WYB

26.3%

Bacillus anthracis

Central intermediary metabolism: Other

IDP04450
(show subtarget assignments)

1

cloned

No

YPO0905

218928078

gcvP

glycine dehydrogenase [Yersinia pestis C...

959

conserved gene; putative drug target function;

Phase 4: April 2009

1WYT

19.1%

Yersinia pestis

Energy metabolism

Amino acids and amines

IDP90673
(show subtarget assignments)

8

expressed

No

VC1833

15641835

quinolinate synthetase [Vibrio cholerae ...

353

Predicted Essential

Community Requests

1WZU

30.6%

Vibrio cholerae

IDP92082
(show subtarget assignments)

8

selected

No

TGME49_107570

237845455

glycerol-3-phosphate dehydrogenase, puta...

401

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1X0V

42.4%

Toxoplasma gondii

IDP05064
(show subtarget assignments)

1

cloned

No

CD2370

126699985

nadC

nicotinate-nucleotide pyrophosphorylase ...

270

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1X1O

46.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides

IDP04688
(show subtarget assignments)

1

soluble

No

GBAA4661

47529959

nadC

nicotinate-nucleotide pyrophosphorylase ...

277

putative drug target function;

Phase 4: April 2009

1X1O

43.7%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01813
(show subtarget assignments)

1

purified

No

GBAA1253

47526519

trpB

tryptophan synthase subunit beta [Bacill...

397

Conserved; Drug target functions

Phase 3: June 2008

1X1Q

63%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00082
(show subtarget assignments)

0

work_stopped

No

NTL01ST4427

16423142

lplA

lipoate-protein ligase A

338

Phase 1: October 2007

1X2G

93.2%

Salmonella enterica

Cell envelope

Other

IDP90215
(show subtarget assignments)

8

expressed

No

MYXV_gp009

9633800

m006L

m006L, m6

509

contains kelch motifs, similar to MYX-L-m006R

Community Requests

1X2J

13.9%

Myxoma virus

unknown

0

IDP90531
(show subtarget assignments)

8

cloned

No

Q9KSF9

20139940

RecName: Full=Asparaginyl-tRNA synthetas...

466

Predicted Essential

Community Requests

1X54

35.2%

Vibrio cholerae

IDP05209
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1494

57650409

asnC

asparaginyl-tRNA synthetase [Staphylococ...

430

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

45.8%

Staphylococcus aureus

Protein synthesis: tRNA aminoacylation

IDP90728
(show subtarget assignments)

8

cloned

No

YPO1412

16121692

asnC

asparaginyl-tRNA synthetase [Yersinia pe...

466

Predicted Essential

Community Requests

1X54

34.3%

Yersinia pestis

IDP05239
(show subtarget assignments)

1

cloned

No

lmo1896

16803935

ansB

asparaginyl-tRNA synthetase [Listeria mo...

430

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

45.3%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05569
(show subtarget assignments)

1

soluble

No

BAS4454

49187449

-

asparaginyl-tRNA synthetase [Bacillus an...

463

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1X54

35.9%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP91714
(show subtarget assignments)

8

selected

No

NP_006734

5803137

RBM3

putative RNA-binding protein 3 [Homo sap...

157

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1X5S

41.4%

Homo sapiens

IDP91808
(show subtarget assignments)

8

selected

No

AAB07788

924760

CTCF

CTCF [Homo sapiens]

727

innate immunity / CTCF (CCCTC-binding factor) is an evolutionarily-conserved transcription factor ...

Community Requests

1X6H

10.2%

Homo sapiens

IDP02658
(show subtarget assignments)

1

cloned

No

STM2648

16765968

yfiF

putative methyltransferase [Salmonella t...

345

Conserved; Essential; Drug target functions

Phase 3: June 2008

1X7O

20.6%

Salmonella enterica

Unknown function

General

IDP90999
(show subtarget assignments)

8

cloned

No

y1744

22125639

hypothetical protein y1744 [Yersinia pes...

95

other biological interest / -

Community Requests

1X7V

33.7%

Yersinia pestis

IDP00009
(show subtarget assignments)

1

soluble

No

BA_1538

38372188

3-dehydroquinate synthase

363

Drug Target Homolog

Phase 1: October 2007

1XAG

38.3%

Bacillus anthracis

Amino acid biosynthesis

Aromatic amino acid family

IDP00638
(show subtarget assignments)

1

purified

No

SACOL2736

57285290

gidB

glucose-inhibited division protein B

239

Drug Target Function

Phase 2: March 2008

1XDZ

63.2%

Staphylococcus aureus

Unknown function

General

IDP91512
(show subtarget assignments)

8

cloned

No

VV2_0404

27366843

cytolysin [Vibrio vulnificus CMCP6]

468

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XEZ

25.9%

Vibrio vulnificus

IDP01348
(show subtarget assignments)

0

work_stopped

No

VCA0219

15600988

haemolysin

741

Conserved Gene / Pathway

Phase 2: March 2008

1XEZ

94.7%

Vibrio cholerae

Cellular processes

Pathogenesis

IDP90537
(show subtarget assignments)

8

purified

No

Q9KL24

21542209

RecName: Full=Dihydroorotase; Short=DHOa...

342

Predicted Essential

Community Requests

1XGE

55%

Vibrio cholerae

IDP01857
(show subtarget assignments)

1

soluble

No

FTT1034c

56708121

ndh

NADH dehydrogenase [Francisella tularens...

420

Drug Target

Phase 3: June 2008

1XHC

21%

Francisella tularensis

Energy metabolism

Electron transport

IDP00081
(show subtarget assignments)

1

in_crystallization_trials

No

NT01ST5473

16422973

ytfP

putative cytoplasmic protein

114

Essential

Phase 1: October 2007

1XHS

92.1%

Salmonella enterica

Unknown function

General

IDP05512
(show subtarget assignments)

1

cloned

No

CD1601

126699205

thiE1

thiamine-phosphate pyrophosphorylase [Cl...

210

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XI3

41%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP04167
(show subtarget assignments)

1

cloned

No

VC1977

9656518

aspartate aminotransferase, putative [Vi...

404

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XI9

40.8%

Vibrio cholerae

Amino acid biosynthesis

Aspartate family

IDP91487
(show subtarget assignments)

8

soluble

No

VP1697

28898471

putative type III export apparatus prote...

142

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XKP

20.4%

Vibrio parahaemolyticus

IDP91507
(show subtarget assignments)

8

expressed

No

VP1667

28898441

putative outer membrane protein PopN [Vi...

297

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XKP

29.3%

Vibrio parahaemolyticus

IDP91509
(show subtarget assignments)

8

soluble

No

VP1665

28898439

putative type III secretion protein [Vib...

123

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XKP

35.8%

Vibrio parahaemolyticus

IDP91508
(show subtarget assignments)

8

cloned

No

VP1666

28898440

hypothetical protein VP1666 [Vibrio para...

94

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1XL3

44.7%

Vibrio parahaemolyticus

IDP02191
(show subtarget assignments)

1

expressed

No

FTT0878c

56707982

msrB

methionine sulfoxide reductase B [Franci...

170

Drug Target

Phase 3: June 2008

1XM0

47.6%

Francisella tularensis

Cell envelopeProtein fate

Surface structuresProtein modification and repair

IDP04018
(show subtarget assignments)

1

cloned

No

CPF_1860

110799668

msrB

methionine sulfoxide reductase B [Clostr...

147

conserved gene; putative drug target function;

Phase 4: April 2009

1XM0

64.6%

Clostridium perfringens

Cellular processes

Adaptations to atypical conditions

IDP05519
(show subtarget assignments)

1

cloned

No

CD1704

126699311

thiG

thiazole synthase [Clostridium difficile...

261

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XM3

47.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP01032
(show subtarget assignments)

1

soluble

No

STM3507

16766795

yhgG

putative cytoplasmic protein

78

Conserved Gene / Pathway

Phase 2: March 2008

1XN7

89.7%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP01392
(show subtarget assignments)

1

purified

No

VC0648

15640668

lipoprotein NlpI

303

Conserved Gene / Pathway

Phase 2: March 2008

1XNF

44.2%

Vibrio cholerae

Cell envelope

Other

IDP05031
(show subtarget assignments)

1

soluble

No

BA_0908

30254654

oligopeptide ABC transporter, oligopepti...

528

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

30.7%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05135
(show subtarget assignments)

1

soluble

No

CD0855

126698435

oppA

oligopeptide ABC transporter, substrate-...

522

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

33.1%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP04198
(show subtarget assignments)

1

soluble

No

CPF_2555

110799167

oligopeptide/dipeptide ABC transporter, ...

580

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XOC

29.8%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP02198
(show subtarget assignments)

1

cloned

No

YPO1273

16121558

putative substrate-binding transport pro...

602

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1XOC

21.6%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP05074
(show subtarget assignments)

1

cloned

No

lmo0135

16802183

-

hypothetical protein lmo0135 [Listeria m...

524

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

32.4%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP01206
(show subtarget assignments)

1

purified

No

BA_2446

30257076

N-acetylmuramoyl-L-alanine amidase, fami...

245

Conserved Gene / Pathway

Phase 2: March 2008

1XOV

26.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05345
(show subtarget assignments)

1

soluble

No

Z3383

12516442

pbpG

penicillin-binding protein 7 [Escherichi...

313

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1XP4

25.9%

Escherichia coli

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01885
(show subtarget assignments)

1

cloned

No

GBAA5639

47530965

D-alanyl-D-alanine carboxypeptidase, put...

423

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01881
(show subtarget assignments)

1

cloned

No

GBAA0009

47525265

dacA

D-alanyl-D-alanine carboxypeptidase [Bac...

435

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

32.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02399
(show subtarget assignments)

1

cloned

No

GBAA2559

47527848

D-alanyl-D-alanine carboxypeptidase fami...

338

Drug target motif; Drug target functions

Phase 3: June 2008

1XP4

26.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01726
(show subtarget assignments)

1

cloned

No

GBAA5252

47530558

D-alanyl-D-alanine carboxypeptidase fami...

279

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1XP4

29.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92076
(show subtarget assignments)

8

selected

No

TGME49_097060

237843677

phosphoglycerate mutase 1, putative [Tox...

265

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1XQ9

70.2%

Toxoplasma gondii