Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00863 (show subtarget assignments)	1	expressed	No	STM2254	16765582	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP00833 (show subtarget assignments)	1	cloned	No	SACOL2627	57286532	betA	choline dehydrogenase	569	Conserved Gene / Pathway	Phase 2: March 2008	3LJP	32.7%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP04388 (show subtarget assignments)	1	soluble	No	VC2751	15642744		adenosine deaminase [Vibrio cholerae O1 ...	334	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A4L	32.7%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP05514 (show subtarget assignments)	1	purified	No	CD1315	126698913	ribC	riboflavin biosynthesis protein [Clostri...	309	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MRZ	32.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05572 (show subtarget assignments)	1	cloned	No	BAS4090	49187088	-	stage III sporulation protein AH [Bacill...	223	essential/virulence/pathogenesis / associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3TUF	32.7%	Bacillus anthracis	Cellular processes: Sporulation and germination

IDP01504 (show subtarget assignments)	1	expressed	No	VCA1028	15601781	lamB	maltoporin	416	Conserved Gene / Pathway	Phase 2: March 2008	1AF6	32.7%	Vibrio cholerae	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00341 (show subtarget assignments)	1	cloned	No	FTT1305c	56708363	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	444	Drug Target Function	Phase 2: March 2008	3SG1	32.7%	Francisella tularensis

IDP91348 (show subtarget assignments)	8	soluble	No	VV1_3127	27366393		response regulator [Vibrio vulnificus CM...	304	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3BRE	32.7%	Vibrio vulnificus

IDP91194 (show subtarget assignments)	8	cloned	No	BAS4090	49187088	-	Stage III sporulation protein AH	223	essential/virulence/pathogenesis / Essential proteins	Community Requests	3TUF	32.7%	Bacillus anthracis

IDP01758 (show subtarget assignments)	1	expressed	No	CBU_0728	29541328		ABC transporter, ATP-binding protein [Co...	268	Conserved; Drug target functions	Phase 3: June 2008	1B0U	32.8%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP90613 (show subtarget assignments)	8	soluble	No	Cj0828c	15792166	ilvA	threonine dehydratase [Campylobacter jej...	403	Predicted Essential	Community Requests	1TDJ	32.8%	Campylobacter jejuni

IDP01648 (show subtarget assignments)	1	cloned	No	YPO2944	16123127		putative pili chaperone protein [Yersini...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.8%	Yersinia pestis	Cell envelope	Surface structures

IDP90780 (show subtarget assignments)	8	soluble	No	VC0215	15640245		bifunctional phosphopantothenoylcysteine...	399	Predicted Essential	Community Requests	1U7U	32.8%	Vibrio cholerae

IDP02809 (show subtarget assignments)	1	cloned	No	lmo2025	16804064	nadA	quinolinate synthetase [Listeria monocyt...	366	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	2QS0	32.8%	Listeria monocytogenes	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridine nucleotides

IDP01468 (show subtarget assignments)	1	purified	No	VC2553	15642548		ABC transporter, ATP-binding protein, au...	238	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	32.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP91430 (show subtarget assignments)	8	cloned	No	VV1_0534	27363997		ATP-dependent RNA helicase SrmB [Vibrio ...	408	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2I4I	32.8%	Vibrio vulnificus

IDP00325 (show subtarget assignments)	1	crystallized	No	Cj1530	15792838	coaE	dephospho-CoA kinase	201	Drug Target Function	Phase 2: March 2008	2IF2	32.8%	Campylobacter jejuni	Unclassified	Unclassified

IDP91079 (show subtarget assignments)	8	cloned	No	BMA0204	53725011		ABC transporter, ATP-binding/permease pr...	623	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	4AA3	32.8%	Burkholderia mallei

IDP01150 (show subtarget assignments)	1	expressed	No	BA_4493	34582388		Phosphate import ATP-binding protein pst...	271	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.8%	Bacillus anthracis	Transport and binding proteins	Anions

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01026 (show subtarget assignments)	1	cloned	No	STM1267	16764618		putative cytoplasmic protein	82	Conserved Gene / Pathway	Phase 2: March 2008	2OXL	32.9%	Salmonella enterica	Protein synthesis	tRNA aminoacylation

IDP04127 (show subtarget assignments)	1	crystallized	No	YPO2889	115348559	pepB	peptidase B [Yersinia pestis CO92]	432	drug target; putative drug target function;	Phase 4: April 2009	1BLL	32.9%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91900 (show subtarget assignments)	8	selected	No	SpneCM_010100003670	298254699		ABC transporter, ATP-binding/permease pr...	581	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3B5X	32.9%	Streptococcus pneumoniae

IDP04299 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0840	15601595		deoxycytidylate deaminase, putative [Vib...	161	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2W4L	32.9%	Vibrio cholerae	Purines, pyrimidines, nucleosides, and nucleotides	Other

IDP02053 (show subtarget assignments)	1	soluble	No	YPO3699	16123838		hypothetical protein YPO3699 [Yersinia p...	158	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3OD9	32.9%	Yersinia pestis	Cell envelope	Other

IDP05195 (show subtarget assignments)	1	soluble	No	CD0873	126698450		ABC transporter, substrate-binding lipop...	340	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3LKV	32.9%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP91684 (show subtarget assignments)	8	selected	No	NCAP_CVHSA	0			422	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1SSK	32.9%	SARS coronavirus

IDP00717 (show subtarget assignments)	1	cloned	No	SACOL1421	57286072		phosphate ABC transporter, ATP-binding p...	283	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	32.9%	Staphylococcus aureus	Transport and binding proteins	Anions

IDP91092 (show subtarget assignments)	8	soluble	No	A1S_1236	193076931		D-arabinose 5-phosphate isomerase [Acine...	325	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	32.9%	Acinetobacter baumannii

IDP90936 (show subtarget assignments)	8	cloned	No	YPO2016	16122259	hemA	glutamyl-tRNA reductase [Yersinia pestis...	420	Predicted Essential	Community Requests	1GPJ	32.9%	Yersinia pestis

IDP00036 (show subtarget assignments)	1	purified	No	BA_1840	30256110		fibronectin-binding protein, putative	213	Virulence	Phase 1: October 2007	2YB5	32.9%	Bacillus anthracis	Cellular processes	Pathogenesis

IDP90510 (show subtarget assignments)	8	soluble	No	Cj1676	15792980	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	258	Predicted Essential	Community Requests	3TX1	32.9%	Campylobacter jejuni

IDP01154 (show subtarget assignments)	1	expressed	No	BA_0139	56748760		Cobalt import ATP-binding protein cbiO 1...	280	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP92007 (show subtarget assignments)	8	selected	No	FTT_0941c	56708038		unnamed protein product [Francisella tul...	306	virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...	Community Requests	3AIK	33%	Francisella tularensis

IDP00902 (show subtarget assignments)	1	expressed	No	STM0045	16763435	ribF	bifunctional riboflavin kinase/FMN adeny...	312	Conserved Gene / Pathway	Phase 2: March 2008	1MRZ	33%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP01761 (show subtarget assignments)	1	cloned	No	GBAA5606	47530928		aminopeptidase, putative [Bacillus anthr...	466	Drug target motif; Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2EK8	33%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP02014 (show subtarget assignments)	1	soluble	No	STM2341	16765668		putative transketolase [Salmonella typhi...	276	Conserved; Drug target functions	Phase 3: June 2008	2E6K	33%	Salmonella enterica	Energy metabolism	Pentose phosphate pathway

IDP04298 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0827	15601582	phhB	pterin-4-alpha-carbinolamine dehydratase...	109	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1RU0	33%	Vibrio cholerae	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90607 (show subtarget assignments)	8	purified	No	VC2015	15642017		DNA polymerase III subunit delta' [Vibri...	324	Predicted Essential	Community Requests	1A5T	33%	Vibrio cholerae

IDP05351 (show subtarget assignments)	1	soluble	No	CD1522	126699126		putative polysaccharide deacetylase [Clo...	293	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2W3Z	33%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01333 (show subtarget assignments)	1	purified	No	VC0726	15640745		phosphate ABC transporter, ATP-binding p...	273	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	33%	Vibrio cholerae	Transport and binding proteins	Anions

IDP02685 (show subtarget assignments)	1	cloned	No	Cj1027c	15792354	gyrA	DNA gyrase subunit A [Campylobacter jeju...	863	Predicted virulence-Resistance to antibiotics and toxic compounds	Phase 3: June 2008	2WL2	33%	Campylobacter jejuni	Energy metabolism	Electron transport

IDP01250 (show subtarget assignments)	1	cloned	No	BA_4497	30259003		penicillin-binding protein	706	Drug Target Function	Phase 2: March 2008	2WAF	33%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01939 (show subtarget assignments)	1	purified	No	STM4126	16767390	udhA	soluble pyridine nucleotide transhydroge...	466	Conserved; Drug target functions	Phase 3: June 2008	3URH	33%	Salmonella enterica	Energy metabolism	Pyruvate dehydrogenase

IDP05240 (show subtarget assignments)	1	expressed	No	CD0233	126697804		hypothetical protein CD0233 [Clostridium...	130	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2AJ7	33.1%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP02555 (show subtarget assignments)	1	expressed	No	CBU_0391	29541001	ribF	riboflavin biosynthesis protein RibF [Co...	320	Conserved; Drug target functions	Phase 3: June 2008	1MRZ	33.1%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Riboflavin, FMN, and FAD

IDP90995 (show subtarget assignments)	8	in_crystallization_trials	No	y1430	22125328		hypothetical protein y1430 [Yersinia pes...	369	other biological interest / putative periplasmic iron-binding protein	Community Requests	3C9H	33.1%	Yersinia pestis

IDP02285 (show subtarget assignments)	1	soluble	No	FTT0132	56707303	glpA	anaerobic glycerol-3-phosphate dehydroge...	510	Drug Target	Phase 3: June 2008	3DA1	33.1%	Francisella tularensis	Energy metabolism	Other

IDP05135 (show subtarget assignments)	1	soluble	No	CD0855	126698435	oppA	oligopeptide ABC transporter, substrate-...	522	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XOC	33.1%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP02182 (show subtarget assignments)	1	cloned	No	FTT0065	56707244	atpC	F0F1 ATP synthase subunit epsilon [Franc...	145	Conserved; Drug target functions	Phase 3: June 2008	2QE7	33.1%	Francisella tularensis	Energy metabolism	ATP-proton motive force interconversion

IDP00626 (show subtarget assignments)	1	cloned	No	SACOL2506	57285191	sarT	staphylococcal accessory regulator T	118	Conserved Gene / Pathway	Phase 2: March 2008	2FNP	33.1%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP92023 (show subtarget assignments)	8	selected	No	TGME49_010260	237845081		glycerol-3-phosphate dehydrogenase, puta...	515	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1YJ8	33.2%	Toxoplasma gondii

IDP02497 (show subtarget assignments)	1	cloned	No	FTT1287	56708346	cbs	cystathionine beta-synthase (cystein syn...	307	Conserved; Drug target functions	Phase 3: June 2008	4AEC	33.2%	Francisella tularensis	Amino acid biosynthesis	Serine family

IDP02770 (show subtarget assignments)	1	cloned	No	GBAA2774	47528065	acoC	branched-chain alpha-keto acid dehydroge...	398	Essential; Drug target functions	Phase 3: June 2008	3DUF	33.2%	Bacillus anthracis	Energy metabolism	Fermentation

IDP01954 (show subtarget assignments)	1	in_crystallization_trials	No	Cj0812	15792150	thrC	threonine synthase [Campylobacter jejuni...	470	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1KL7	33.2%	Campylobacter jejuni	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP00651 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0143	57285346	cap5H	capsular polysaccharide biosynthesis pro...	208	Conserved Gene / Pathway	Phase 2: March 2008	3EEV	33.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02464 (show subtarget assignments)	1	cloned	No	YPO1708	16121968		putative chaperone protein [Yersinia pes...	259	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	33.2%	Yersinia pestis	Cell envelope	Surface structures

IDP01932 (show subtarget assignments)	1	cloned	No	CBU_1099	29541673	lepB-1	signal peptidase I [Coxiella burnetii RS...	259	Conserved; Drug target functions	Phase 3: June 2008	1T7D	33.2%	Coxiella burnetii	Protein fate	Protein and peptide secretion and trafficking

IDP91042 (show subtarget assignments)	8	in_crystallization_trials	No	ACB0002	38230268		AdeR [Acinetobacter baumannii]	247	Regulator protein of transcription of antibiotic drug-efflux pump AdeABC	Community Requests	2GWR	33.2%	Acinetobacter baumannii

IDP91086 (show subtarget assignments)	8	soluble	No	CBU_0750	29541350		KpsF/GutQ family protein	324	potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...	Community Requests	2XHZ	33.3%	Coxiella burnetii	Unknown function: General

IDP02723 (show subtarget assignments)	1	cloned	No	FTT0039	56707219	nuoI	NADH dehydrogenase subunit I [Francisell...	162	Conserved; Drug target functions	Phase 3: June 2008	2FUG	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP05734 (show subtarget assignments)	1	cloned	No	CD1470	126699074		putative phage shock protein [Clostridiu...	99	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3GK5	33.3%	Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP92006 (show subtarget assignments)	8	selected	No	FTN_0818	118497410		lipase/esterase [Francisella novicida U1...	306	virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...	Community Requests	3AIK	33.3%	Francisella novicida

IDP02641 (show subtarget assignments)	1	purified	No	GBAA0640	47525919		amino acid ABC transporter amino acid-bi...	276	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2V25	33.3%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP05414 (show subtarget assignments)	1	expressed	No	BA_4233	30258736		conserved domain protein [Bacillus anthr...	169	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3OML	33.3%	Bacillus anthracis	Hypothetical proteins: Domain

IDP00898 (show subtarget assignments)	1	purified	No	STM2114	16765444	wcaB	putative colanic acid biosynthesis acety...	162	Drug Target Function	Phase 2: March 2008	3GVD	33.3%	Salmonella enterica	Amino acid biosynthesis	Serine family

IDP04295 (show subtarget assignments)	1	cloned	No	FTT0031	56707211	nuoA	NADH dehydrogenase I, A subunit [Francis...	132	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3RKO	33.3%	Francisella tularensis	Energy metabolism	Electron transport

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP00799 (show subtarget assignments)	1	expressed	No	SACOL1403	57284557	trpE	anthranilate synthase component I	468	Drug Target Function	Phase 2: March 2008	1QDL	33.3%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP00416 (show subtarget assignments)	1	expressed	No	YPO1212	16121503		2Fe-2S ferredoxin YfaE	85	Conserved Gene / Pathway	Phase 2: March 2008	3AV8	33.3%	Yersinia pestis	Energy metabolism	Electron transport

IDP04398 (show subtarget assignments)	1	cloned	No	YPO1376	218928524	ftsK	putative cell division protein [Yersinia...	1305	drug target; putative drug target function;	Phase 4: April 2009	2IUS	33.3%	Yersinia pestis	Cellular processes	Cell division

IDP05704 (show subtarget assignments)	1	cloned	No	lmo2639	16804677	-	hypothetical protein lmo2639 [Listeria m...	138	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2KPP	33.3%	Listeria monocytogenes	Hypothetical proteins: Conserved

IDP01393 (show subtarget assignments)	1	in_crystallization_trials	No	VC0684	15640703		peptidyl-prolyl cis-trans isomerase, FKB...	144	Conserved Gene / Pathway	Phase 2: March 2008	2K8I	33.3%	Vibrio cholerae	Protein fate	Protein folding and stabilization

IDP90599 (show subtarget assignments)	8	in_crystallization_trials	No	Cj0460	15791824	nusA	transcription elongation factor NusA [Ca...	362	Predicted Essential	Community Requests	1HH2	33.4%	Campylobacter jejuni

IDP05366 (show subtarget assignments)	1	soluble	No	BA_2255	30256899		putative substrate-binding family protei...	320	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3MWF	33.4%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP02498 (show subtarget assignments)	1	cloned	No	FTT1556c	56708584	lepB	signal peptidase I [Francisella tularens...	287	Conserved; Drug target functions; Drug target motif	Phase 3: June 2008	1B12	33.4%	Francisella tularensis	Protein fate	Protein and peptide secretion and trafficking

IDP01928 (show subtarget assignments)	1	cloned	No	FTT0286c	56707440	lpxD1	UDP-3-O-[3-hydroxymyristoyl] glucosamine...	347	Drug Target	Phase 3: June 2008	2IU8	33.4%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02667 (show subtarget assignments)	1	cloned	No	lmo0565	16802608	hisH	imidazole glycerol phosphate synthase su...	208	Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...	Phase 3: June 2008	1OX4	33.5%	Listeria monocytogenes	Amino acid biosynthesis	Histidine family

IDP05523 (show subtarget assignments)	1	soluble	No	CD2204	126699821		esterase [Clostridium difficile 630]	260	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2UZ0	33.5%	Clostridium difficile	Fatty acid and phospholipid metabolism: Degradation

IDP00977 (show subtarget assignments)	1	expressed	No	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP02539 (show subtarget assignments)	1	cloned	No	YPO3200	16123361	malZ	maltodextrin glucosidase [Yersinia pesti...	609	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1EA9	33.5%	Yersinia pestis	Energy metabolism	Biosynthesis and degradation of polysaccharides

IDP92071 (show subtarget assignments)	8	selected	No	TGME49_011680	211968957		protein disulfide isomerase [Toxoplasma ...	471	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	3F8U	33.5%	Toxoplasma gondii

IDP91892 (show subtarget assignments)	8	selected	No	SpneCM_010100009040	298255720		DNA translocase ftsk [Streptococcus pneu...	741	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2IUT	33.5%	Streptococcus pneumoniae

IDP00848 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1753	57286190		universal stress protein family	137	Conserved Gene / Pathway	Phase 2: March 2008	1MJH	33.5%	Staphylococcus aureus	Cellular processes	Adaptations to atypical conditions

IDP91785 (show subtarget assignments)	8	purified	No	ABQ00063	145974708	cfr	Cfr [Staphylococcus aureus]	349	drug resistance / Chloramphenicol-florfenicol resistance protein	Community Requests	3RF9	33.5%	Staphylococcus aureus

IDP91026 (show subtarget assignments)	8	cloned	No	y3142	22127018		flavodoxin [Yersinia pestis KIM 10]	149	other biological interest / oxidative stress response protein	Community Requests	2HNA	33.6%	Yersinia pestis

IDP02368 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0422	56707569	murF	UDP-N--acetylmuramoylalanyl-D-glutamyl-2...	452	Conserved; Drug target functions	Phase 3: June 2008	1GG4	33.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92127 (show subtarget assignments)	8	selected	No	TGME49_021310	237841325		aminopeptidase N, putative [Toxoplasma g...	966	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	2GTQ	33.6%	Toxoplasma gondii

IDP04405 (show subtarget assignments)	1	cloned	No	CPF_2987	110799346		stage 0 sporulation protein J [Clostridi...	286	conserved gene; putative drug target function;	Phase 4: April 2009	1VZ0	33.6%	Clostridium perfringens	Cellular processes	Sporulation and germination

IDP05433 (show subtarget assignments)	1	soluble	No	lmo1730	16803770	-	hypothetical protein lmo1730 [Listeria m...	414	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3UOR	33.6%	Listeria monocytogenes	Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP00811 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1873	57284794	epiF	epidermin immunity protein F	230	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	33.6%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP91198 (show subtarget assignments)	8	cloned	No	BAS5131	49188117	-	stage II sporulation protein	301	essential/virulence/pathogenesis / Essential proteins	Community Requests	3TUF	33.6%	Bacillus anthracis

IDP01465 (show subtarget assignments)	1	purified	No	VC2528	15642523		ABC transporter, ATP-binding protein	241	Conserved Gene / Pathway	Phase 2: March 2008	1JI0	33.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01427 (show subtarget assignments)	1	purified	No	VC1684	15641688		peptide ABC transporter, ATP-binding pro...	262	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	33.6%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01364 (show subtarget assignments)	1	expressed	No	VC0200	15640230		iron(III) compound receptor	718	Conserved Gene / Pathway	Phase 2: March 2008	3QLB	33.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00689 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2073	57284941	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	452	Conserved Gene / Pathway	Phase 2: March 2008	2AM1	33.6%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04512 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_2342	110798786	modA	molybdate ABC transporter, molybdate-bin...	256	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1AMF	33.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP05246 (show subtarget assignments)	1	soluble	No	lmo2439	16804477	-	hypothetical protein lmo2439 [Listeria m...	113	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K5Q	33.6%	Listeria monocytogenes	Unclassified: Role category not yet assigned

IDP02387 (show subtarget assignments)	1	expressed	No	FTT1304c	56708362	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	282	Conserved; Drug target functions	Phase 3: June 2008	3TX1	33.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00115 (show subtarget assignments)	1	crystallized	No	NT01VPA0514	28900406	VPA0551	hypothetical protein VPA0551 (gi 2890040...	181	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2OT9	33.7%	Vibrio parahaemolyticus	Cellular processes	Toxin production and resistance

IDP00863
(show subtarget assignments)

1

expressed

No

STM2254

16765582

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP00833
(show subtarget assignments)

1

cloned

No

SACOL2627

57286532

betA

choline dehydrogenase

569

Conserved Gene / Pathway

Phase 2: March 2008

3LJP

32.7%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP04388
(show subtarget assignments)

1

soluble

No

VC2751

15642744

adenosine deaminase [Vibrio cholerae O1 ...

334

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A4L

32.7%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP05514
(show subtarget assignments)

1

purified

No

CD1315

126698913

ribC

riboflavin biosynthesis protein [Clostri...

309

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MRZ

32.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05572
(show subtarget assignments)

1

cloned

No

BAS4090

49187088

-

stage III sporulation protein AH [Bacill...

223

essential/virulence/pathogenesis / associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3TUF

32.7%

Bacillus anthracis

Cellular processes: Sporulation and germination

IDP01504
(show subtarget assignments)

1

expressed

No

VCA1028

15601781

lamB

maltoporin

416

Conserved Gene / Pathway

Phase 2: March 2008

1AF6

32.7%

Vibrio cholerae

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00341
(show subtarget assignments)

1

cloned

No

FTT1305c

56708363

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

444

Drug Target Function

Phase 2: March 2008

3SG1

32.7%

Francisella tularensis

IDP91348
(show subtarget assignments)

8

soluble

No

VV1_3127

27366393

response regulator [Vibrio vulnificus CM...

304

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3BRE

32.7%

Vibrio vulnificus

IDP91194
(show subtarget assignments)

8

cloned

No

BAS4090

49187088

-

Stage III sporulation protein AH

223

essential/virulence/pathogenesis / Essential proteins

Community Requests

3TUF

32.7%

Bacillus anthracis

IDP01758
(show subtarget assignments)

1

expressed

No

CBU_0728

29541328

ABC transporter, ATP-binding protein [Co...

268

Conserved; Drug target functions

Phase 3: June 2008

1B0U

32.8%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP90613
(show subtarget assignments)

8

soluble

No

Cj0828c

15792166

ilvA

threonine dehydratase [Campylobacter jej...

403

Predicted Essential

Community Requests

1TDJ

32.8%

Campylobacter jejuni

IDP01648
(show subtarget assignments)

1

cloned

No

YPO2944

16123127

putative pili chaperone protein [Yersini...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.8%

Yersinia pestis

Cell envelope

Surface structures

IDP90780
(show subtarget assignments)

8

soluble

No

VC0215

15640245

bifunctional phosphopantothenoylcysteine...

399

Predicted Essential

Community Requests

1U7U

32.8%

Vibrio cholerae

IDP02809
(show subtarget assignments)

1

cloned

No

lmo2025

16804064

nadA

quinolinate synthetase [Listeria monocyt...

366

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

2QS0

32.8%

Listeria monocytogenes

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridine nucleotides

IDP01468
(show subtarget assignments)

1

purified

No

VC2553

15642548

ABC transporter, ATP-binding protein, au...

238

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

32.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP91430
(show subtarget assignments)

8

cloned

No

VV1_0534

27363997

ATP-dependent RNA helicase SrmB [Vibrio ...

408

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2I4I

32.8%

Vibrio vulnificus

IDP00325
(show subtarget assignments)

1

crystallized

No

Cj1530

15792838

coaE

dephospho-CoA kinase

201

Drug Target Function

Phase 2: March 2008

2IF2

32.8%

Campylobacter jejuni

Unclassified

IDP91079
(show subtarget assignments)

8

cloned

No

BMA0204

53725011

ABC transporter, ATP-binding/permease pr...

623

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

4AA3

32.8%

Burkholderia mallei

IDP01150
(show subtarget assignments)

1

expressed

No

BA_4493

34582388

Phosphate import ATP-binding protein pst...

271

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.8%

Bacillus anthracis

Transport and binding proteins

Anions

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01026
(show subtarget assignments)

1

cloned

No

STM1267

16764618

putative cytoplasmic protein

82

Conserved Gene / Pathway

Phase 2: March 2008

2OXL

32.9%

Salmonella enterica

Protein synthesis

tRNA aminoacylation

IDP04127
(show subtarget assignments)

1

crystallized

No

YPO2889

115348559

pepB

peptidase B [Yersinia pestis CO92]

432

drug target; putative drug target function;

Phase 4: April 2009

1BLL

32.9%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91900
(show subtarget assignments)

8

selected

No

SpneCM_010100003670

298254699

ABC transporter, ATP-binding/permease pr...

581

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3B5X

32.9%

Streptococcus pneumoniae

IDP04299
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0840

15601595

deoxycytidylate deaminase, putative [Vib...

161

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2W4L

32.9%

Vibrio cholerae

Purines, pyrimidines, nucleosides, and nucleotides

Other

IDP02053
(show subtarget assignments)

1

soluble

No

YPO3699

16123838

hypothetical protein YPO3699 [Yersinia p...

158

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3OD9

32.9%

Yersinia pestis

Cell envelope

Other

IDP05195
(show subtarget assignments)

1

soluble

No

CD0873

126698450

ABC transporter, substrate-binding lipop...

340

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3LKV

32.9%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP91684
(show subtarget assignments)

8

selected

No

NCAP_CVHSA

0

422

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1SSK

32.9%

SARS coronavirus

IDP00717
(show subtarget assignments)

1

cloned

No

SACOL1421

57286072

phosphate ABC transporter, ATP-binding p...

283

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

32.9%

Staphylococcus aureus

Transport and binding proteins

Anions

IDP91092
(show subtarget assignments)

8

soluble

No

A1S_1236

193076931

D-arabinose 5-phosphate isomerase [Acine...

325

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

32.9%

Acinetobacter baumannii

IDP90936
(show subtarget assignments)

8

cloned

No

YPO2016

16122259

hemA

glutamyl-tRNA reductase [Yersinia pestis...

420

Predicted Essential

Community Requests

1GPJ

32.9%

Yersinia pestis

IDP00036
(show subtarget assignments)

1

purified

No

BA_1840

30256110

fibronectin-binding protein, putative

213

Virulence

Phase 1: October 2007

2YB5

32.9%

Bacillus anthracis

Cellular processes

Pathogenesis

IDP90510
(show subtarget assignments)

8

soluble

No

Cj1676

15792980

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

258

Predicted Essential

Community Requests

3TX1

32.9%

Campylobacter jejuni

IDP01154
(show subtarget assignments)

1

expressed

No

BA_0139

56748760

Cobalt import ATP-binding protein cbiO 1...

280

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP92007
(show subtarget assignments)

8

selected

No

FTT_0941c

56708038

unnamed protein product [Francisella tul...

306

virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...

Community Requests

3AIK

33%

Francisella tularensis

IDP00902
(show subtarget assignments)

1

expressed

No

STM0045

16763435

ribF

bifunctional riboflavin kinase/FMN adeny...

312

Conserved Gene / Pathway

Phase 2: March 2008

1MRZ

33%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP01761
(show subtarget assignments)

1

cloned

No

GBAA5606

47530928

aminopeptidase, putative [Bacillus anthr...

466

Drug target motif; Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2EK8

33%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP02014
(show subtarget assignments)

1

soluble

No

STM2341

16765668

putative transketolase [Salmonella typhi...

276

Conserved; Drug target functions

Phase 3: June 2008

2E6K

33%

Salmonella enterica

Energy metabolism

Pentose phosphate pathway

IDP04298
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0827

15601582

phhB

pterin-4-alpha-carbinolamine dehydratase...

109

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1RU0

33%

Vibrio cholerae

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90607
(show subtarget assignments)

8

purified

No

VC2015

15642017

DNA polymerase III subunit delta' [Vibri...

324

Predicted Essential

Community Requests

1A5T

33%

Vibrio cholerae

IDP05351
(show subtarget assignments)

1

soluble

No

CD1522

126699126

putative polysaccharide deacetylase [Clo...

293

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2W3Z

33%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01333
(show subtarget assignments)

1

purified

No

VC0726

15640745

phosphate ABC transporter, ATP-binding p...

273

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

33%

Vibrio cholerae

Transport and binding proteins

Anions

IDP02685
(show subtarget assignments)

1

cloned

No

Cj1027c

15792354

gyrA

DNA gyrase subunit A [Campylobacter jeju...

863

Predicted virulence-Resistance to antibiotics and toxic compounds

Phase 3: June 2008

2WL2

33%

Campylobacter jejuni

Energy metabolism

Electron transport

IDP01250
(show subtarget assignments)

1

cloned

No

BA_4497

30259003

penicillin-binding protein

706

Drug Target Function

Phase 2: March 2008

2WAF

33%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01939
(show subtarget assignments)

1

purified

No

STM4126

16767390

udhA

soluble pyridine nucleotide transhydroge...

466

Conserved; Drug target functions

Phase 3: June 2008

3URH

33%

Salmonella enterica

Energy metabolism

Pyruvate dehydrogenase

IDP05240
(show subtarget assignments)

1

expressed

No

CD0233

126697804

hypothetical protein CD0233 [Clostridium...

130

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2AJ7

33.1%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP02555
(show subtarget assignments)

1

expressed

No

CBU_0391

29541001

ribF

riboflavin biosynthesis protein RibF [Co...

320

Conserved; Drug target functions

Phase 3: June 2008

1MRZ

33.1%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Riboflavin, FMN, and FAD

IDP90995
(show subtarget assignments)

8

in_crystallization_trials

No

y1430

22125328

hypothetical protein y1430 [Yersinia pes...

369

other biological interest / putative periplasmic iron-binding protein

Community Requests

3C9H

33.1%

Yersinia pestis

IDP02285
(show subtarget assignments)

1

soluble

No

FTT0132

56707303

glpA

anaerobic glycerol-3-phosphate dehydroge...

510

Drug Target

Phase 3: June 2008

3DA1

33.1%

Francisella tularensis

Energy metabolism

Other

IDP05135
(show subtarget assignments)

1

soluble

No

CD0855

126698435

oppA

oligopeptide ABC transporter, substrate-...

522

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XOC

33.1%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP02182
(show subtarget assignments)

1

cloned

No

FTT0065

56707244

atpC

F0F1 ATP synthase subunit epsilon [Franc...

145

Conserved; Drug target functions

Phase 3: June 2008

2QE7

33.1%

Francisella tularensis

Energy metabolism

ATP-proton motive force interconversion

IDP00626
(show subtarget assignments)

1

cloned

No

SACOL2506

57285191

sarT

staphylococcal accessory regulator T

118

Conserved Gene / Pathway

Phase 2: March 2008

2FNP

33.1%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP92023
(show subtarget assignments)

8

selected

No

TGME49_010260

237845081

glycerol-3-phosphate dehydrogenase, puta...

515

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1YJ8

33.2%

Toxoplasma gondii

IDP02497
(show subtarget assignments)

1

cloned

No

FTT1287

56708346

cbs

cystathionine beta-synthase (cystein syn...

307

Conserved; Drug target functions

Phase 3: June 2008

4AEC

33.2%

Francisella tularensis

Amino acid biosynthesis

Serine family

IDP02770
(show subtarget assignments)

1

cloned

No

GBAA2774

47528065

acoC

branched-chain alpha-keto acid dehydroge...

398

Essential; Drug target functions

Phase 3: June 2008

3DUF

33.2%

Bacillus anthracis

Energy metabolism

Fermentation

IDP01954
(show subtarget assignments)

1

in_crystallization_trials

No

Cj0812

15792150

thrC

threonine synthase [Campylobacter jejuni...

470

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1KL7

33.2%

Campylobacter jejuni

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP00651
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0143

57285346

cap5H

capsular polysaccharide biosynthesis pro...

208

Conserved Gene / Pathway

Phase 2: March 2008

3EEV

33.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02464
(show subtarget assignments)

1

cloned

No

YPO1708

16121968

putative chaperone protein [Yersinia pes...

259

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

33.2%

Yersinia pestis

Cell envelope

Surface structures

IDP01932
(show subtarget assignments)

1

cloned

No

CBU_1099

29541673

lepB-1

signal peptidase I [Coxiella burnetii RS...

259

Conserved; Drug target functions

Phase 3: June 2008

1T7D

33.2%

Coxiella burnetii

Protein fate

Protein and peptide secretion and trafficking

IDP91042
(show subtarget assignments)

8

in_crystallization_trials

No

ACB0002

38230268

AdeR [Acinetobacter baumannii]

247

Regulator protein of transcription of antibiotic drug-efflux pump AdeABC

Community Requests

2GWR

33.2%

Acinetobacter baumannii

IDP91086
(show subtarget assignments)

8

soluble

No

CBU_0750

29541350

KpsF/GutQ family protein

324

potential drug target / KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...

Community Requests

2XHZ

33.3%

Coxiella burnetii

Unknown function: General

IDP02723
(show subtarget assignments)

1

cloned

No

FTT0039

56707219

nuoI

NADH dehydrogenase subunit I [Francisell...

162

Conserved; Drug target functions

Phase 3: June 2008

2FUG

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP05734
(show subtarget assignments)

1

cloned

No

CD1470

126699074

putative phage shock protein [Clostridiu...

99

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3GK5

33.3%

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP92006
(show subtarget assignments)

8

selected

No

FTN_0818

118497410

lipase/esterase [Francisella novicida U1...

306

virulence/pathogenesis / We have shown that this protein is involved in Francisella virulence in vivo and...

Community Requests

3AIK

33.3%

Francisella novicida

IDP02641
(show subtarget assignments)

1

purified

No

GBAA0640

47525919

amino acid ABC transporter amino acid-bi...

276

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2V25

33.3%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP05414
(show subtarget assignments)

1

expressed

No

BA_4233

30258736

conserved domain protein [Bacillus anthr...

169

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3OML

33.3%

Bacillus anthracis

Hypothetical proteins: Domain

IDP00898
(show subtarget assignments)

1

purified

No

STM2114

16765444

wcaB

putative colanic acid biosynthesis acety...

162

Drug Target Function

Phase 2: March 2008

3GVD

33.3%

Salmonella enterica

Amino acid biosynthesis

Serine family

IDP04295
(show subtarget assignments)

1

cloned

No

FTT0031

56707211

nuoA

NADH dehydrogenase I, A subunit [Francis...

132

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3RKO

33.3%

Francisella tularensis

Energy metabolism

Electron transport

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP00799
(show subtarget assignments)

1

expressed

No

SACOL1403

57284557

trpE

anthranilate synthase component I

468

Drug Target Function

Phase 2: March 2008

1QDL

33.3%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP00416
(show subtarget assignments)

1

expressed

No

YPO1212

16121503

2Fe-2S ferredoxin YfaE

85

Conserved Gene / Pathway

Phase 2: March 2008

3AV8

33.3%

Yersinia pestis

Energy metabolism

Electron transport

IDP04398
(show subtarget assignments)

1

cloned

No

YPO1376

218928524

ftsK

putative cell division protein [Yersinia...

1305

drug target; putative drug target function;

Phase 4: April 2009

2IUS

33.3%

Yersinia pestis

Cellular processes

Cell division

IDP05704
(show subtarget assignments)

1

cloned

No

lmo2639

16804677

-

hypothetical protein lmo2639 [Listeria m...

138

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2KPP

33.3%

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP01393
(show subtarget assignments)

1

in_crystallization_trials

No

VC0684

15640703

peptidyl-prolyl cis-trans isomerase, FKB...

144

Conserved Gene / Pathway

Phase 2: March 2008

2K8I

33.3%

Vibrio cholerae

Protein fate

Protein folding and stabilization

IDP90599
(show subtarget assignments)

8

in_crystallization_trials

No

Cj0460

15791824

nusA

transcription elongation factor NusA [Ca...

362

Predicted Essential

Community Requests

1HH2

33.4%

Campylobacter jejuni

IDP05366
(show subtarget assignments)

1

soluble

No

BA_2255

30256899

putative substrate-binding family protei...

320

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3MWF

33.4%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP02498
(show subtarget assignments)

1

cloned

No

FTT1556c

56708584

lepB

signal peptidase I [Francisella tularens...

287

Conserved; Drug target functions; Drug target motif

Phase 3: June 2008

1B12

33.4%

Francisella tularensis

Protein fate

Protein and peptide secretion and trafficking

IDP01928
(show subtarget assignments)

1

cloned

No

FTT0286c

56707440

lpxD1

UDP-3-O-[3-hydroxymyristoyl] glucosamine...

347

Drug Target

Phase 3: June 2008

2IU8

33.4%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02667
(show subtarget assignments)

1

cloned

No

lmo0565

16802608

hisH

imidazole glycerol phosphate synthase su...

208

Predicted Essential-Modeling; Predicted involvement in glycosyl group metabolism...

Phase 3: June 2008

1OX4

33.5%

Listeria monocytogenes

Amino acid biosynthesis

Histidine family

IDP05523
(show subtarget assignments)

1

soluble

No

CD2204

126699821

esterase [Clostridium difficile 630]

260

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2UZ0

33.5%

Clostridium difficile

Fatty acid and phospholipid metabolism: Degradation

IDP00977
(show subtarget assignments)

1

expressed

No

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP02539
(show subtarget assignments)

1

cloned

No

YPO3200

16123361

malZ

maltodextrin glucosidase [Yersinia pesti...

609

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1EA9

33.5%

Yersinia pestis

Energy metabolism

Biosynthesis and degradation of polysaccharides

IDP92071
(show subtarget assignments)

8

selected

No

TGME49_011680

211968957

protein disulfide isomerase [Toxoplasma ...

471

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

3F8U

33.5%

Toxoplasma gondii

IDP91892
(show subtarget assignments)

8

selected

No

SpneCM_010100009040

298255720

DNA translocase ftsk [Streptococcus pneu...

741

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2IUT

33.5%

Streptococcus pneumoniae

IDP00848
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1753

57286190

universal stress protein family

137

Conserved Gene / Pathway

Phase 2: March 2008

1MJH

33.5%

Staphylococcus aureus

Cellular processes

Adaptations to atypical conditions

IDP91785
(show subtarget assignments)

8

purified

No

ABQ00063

145974708

cfr

Cfr [Staphylococcus aureus]

349

drug resistance / Chloramphenicol-florfenicol resistance protein

Community Requests

3RF9

33.5%

Staphylococcus aureus

IDP91026
(show subtarget assignments)

8

cloned

No

y3142

22127018

flavodoxin [Yersinia pestis KIM 10]

149

other biological interest / oxidative stress response protein

Community Requests

2HNA

33.6%

Yersinia pestis

IDP02368
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0422

56707569

murF

UDP-N--acetylmuramoylalanyl-D-glutamyl-2...

452

Conserved; Drug target functions

Phase 3: June 2008

1GG4

33.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP92127
(show subtarget assignments)

8

selected

No

TGME49_021310

237841325

aminopeptidase N, putative [Toxoplasma g...

966

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

2GTQ

33.6%

Toxoplasma gondii

IDP04405
(show subtarget assignments)

1

cloned

No

CPF_2987

110799346

stage 0 sporulation protein J [Clostridi...

286

conserved gene; putative drug target function;

Phase 4: April 2009

1VZ0

33.6%

Clostridium perfringens

Cellular processes

Sporulation and germination

IDP05433
(show subtarget assignments)

1

soluble

No

lmo1730

16803770

-

hypothetical protein lmo1730 [Listeria m...

414

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3UOR

33.6%

Listeria monocytogenes

Transport and binding proteins: Carbohydrates, organic alcohols, and acids

IDP00811
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1873

57284794

epiF

epidermin immunity protein F

230

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

33.6%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP91198
(show subtarget assignments)

8

cloned

No

BAS5131

49188117

-

stage II sporulation protein

301

essential/virulence/pathogenesis / Essential proteins

Community Requests

3TUF

33.6%

Bacillus anthracis

IDP01465
(show subtarget assignments)

1

purified

No

VC2528

15642523

ABC transporter, ATP-binding protein

241

Conserved Gene / Pathway

Phase 2: March 2008

1JI0

33.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01427
(show subtarget assignments)

1

purified

No

VC1684

15641688

peptide ABC transporter, ATP-binding pro...

262

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

33.6%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01364
(show subtarget assignments)

1

expressed

No

VC0200

15640230

iron(III) compound receptor

718

Conserved Gene / Pathway

Phase 2: March 2008

3QLB

33.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00689
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2073

57284941

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

452

Conserved Gene / Pathway

Phase 2: March 2008

2AM1

33.6%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04512
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_2342

110798786

modA

molybdate ABC transporter, molybdate-bin...

256

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1AMF

33.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP05246
(show subtarget assignments)

1

soluble

No

lmo2439

16804477

-

hypothetical protein lmo2439 [Listeria m...

113

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K5Q

33.6%

Listeria monocytogenes

Unclassified: Role category not yet assigned

IDP02387
(show subtarget assignments)

1

expressed

No

FTT1304c

56708362

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

282

Conserved; Drug target functions

Phase 3: June 2008

3TX1

33.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00115
(show subtarget assignments)

1

crystallized

No

NT01VPA0514

28900406

VPA0551

hypothetical protein VPA0551 (gi 2890040...

181

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2OT9

33.7%

Vibrio parahaemolyticus

Cellular processes

Toxin production and resistance