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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 17 of 60, showing 100 records out of 5973 total, starting on record 1601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP04338
(
show subtarget assignments
)
1
cloned
No
CPF_1446
110801179
sodF
Mn/Fe superoxide dismutase [Clostridium ...
227
conserved gene; putative drug target function;
Phase 4: April 2009
1JR9
44.9%
Clostridium perfringens
Cellular processes
Detoxification
IDP91901
(
show subtarget assignments
)
8
selected
No
SpneCM_010100002026
298254377
amino acid ABC transporter, permease pro...
227
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP01737
(
show subtarget assignments
)
1
soluble
No
STM3690
16766975
putative inner membrane lipoprotein [Sal...
227
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Unknown function
General
IDP92025
(
show subtarget assignments
)
8
selected
No
TGME49_016130
237843251
ubiquitin-conjugating enzyme E2, putativ...
227
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2AAK
46.3%
Toxoplasma gondii
IDP90278
(
show subtarget assignments
)
8
crystallized
No
TGME49_003450
211965291
hypothetical protein, conserved [Toxopla...
227
Unpublished data from signature-tagged mutagenesis (STM) has identified this nov...
Community Requests
2PD0
41.9%
Toxoplasma gondii
IDP01425
(
show subtarget assignments
)
1
expressed
No
VC1630
15641635
ABC transporter, ATP-binding protein
227
Conserved Gene / Pathway
Phase 2: March 2008
1F3O
37%
Vibrio cholerae
Transport and binding proteins
Unknown substrate
IDP91476
(
show subtarget assignments
)
8
cloned
No
VPA1341
28901196
putative Spa29, component of the Mxi-Spa...
227
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP02025
(
show subtarget assignments
)
1
cloned
No
lmo0394
16802439
hypothetical protein lmo0394 [Listeria m...
227
Possible Vaccine Candidate; Presence of Protease Motifs
Phase 3: June 2008
2XIV
19.8%
Listeria monocytogenes
Unclassified
Role category not yet assigned
IDP00648
(
show subtarget assignments
)
1
cloned
No
SACOL2160
57286373
hemolysin III, putative
227
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP00921
(
show subtarget assignments
)
1
purified
No
STM0507
16763887
ybbA
putative ABC transporter ATP-binding pro...
228
Conserved Gene / Pathway
Phase 2: March 2008
1F3O
42.5%
Salmonella enterica
Transport and binding proteins
Unknown substrate
IDP04042
(
show subtarget assignments
)
1
cloned
No
CPF_0296
110798725
putative cell division ATP-binding prote...
228
conserved gene; putative drug target function;
Phase 4: April 2009
1F3O
40.6%
Clostridium perfringens
Cellular processes
Cell division
IDP02118
(
show subtarget assignments
)
1
cloned
No
STM4388
16767634
sgaE
L-ribulose-5-phosphate 4-epimerase [Salm...
228
Conserved; Drug target functions
Phase 3: June 2008
1JDI
60%
Salmonella enterica
Energy metabolism
Sugars
IDP01320
(
show subtarget assignments
)
1
purified
No
VC1883
15641885
ABC transporter, ATP-binding protein
228
Conserved Gene / Pathway
Phase 2: March 2008
2PCJ
45.6%
Vibrio cholerae
Transport and binding proteins
Unknown substrate
IDP01878
(
show subtarget assignments
)
1
cloned
No
FTT1797c
56708785
msrA2
peptide methionine sulfoxide reductase m...
229
Drug Target
Phase 3: June 2008
3PIN
28.4%
Francisella tularensis
Unclassified
Role category not yet assigned
IDP01861
(
show subtarget assignments
)
1
in_pdb
3IGS
No
STM3337
16766632
nanE
N-acetylmannosamine-6-phosphate 2-epimer...
229
Conserved; Drug target functions
Phase 3: June 2008
3IGS
99.6%
Salmonella enterica
Energy metabolism
Sugars
IDP01982
(
show subtarget assignments
)
1
purified
No
FTT0975
56708067
hypothetical protein FTT0975 [Francisell...
229
Drug Target
Phase 3: June 2008
Francisella tularensis
Cell envelope
Other
IDP04097
(
show subtarget assignments
)
1
cloned
No
CPF_2217
110801384
yunB
sporulation protein YunB [Clostridium pe...
229
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Sporulation and germination
IDP90320
(
show subtarget assignments
)
8
cloned
No
CT_779
3329243
hypothetical protein [Chlamydia trachoma...
229
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90539
(
show subtarget assignments
)
8
crystallized
No
VC2708
15642702
gmk
guanylate kinase [Vibrio cholerae O1 bio...
229
Predicted Essential
Community Requests
1S96
59.8%
Vibrio cholerae
IDP05299
(
show subtarget assignments
)
1
soluble
No
CD2524
126700141
nadD
nicotinate-nucleotide adenylyltransferas...
229
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1KAM
34.9%
Clostridium difficile
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
IDP91441
(
show subtarget assignments
)
8
in_crystallization_trials
No
VV1_0468
27363935
response regulator [Vibrio vulnificus CM...
229
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1B00
45.9%
Vibrio vulnificus
IDP00339
(
show subtarget assignments
)
1
expressed
No
FTT0711
56707830
ispD
2-C-methyl-D-erythritol 4-phosphate cyti...
229
Drug Target Function
Phase 2: March 2008
1H3M
37.1%
Francisella tularensis
IDP91325
(
show subtarget assignments
)
8
cloned
No
VV2_0292
27366738
hypothetical protein VV2_0292 [Vibrio vu...
229
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP90975
(
show subtarget assignments
)
8
cloned
No
y0011
22123933
hypothetical protein y0011 [Yersinia pes...
229
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
2DI3
21.4%
Yersinia pestis
IDP91349
(
show subtarget assignments
)
8
soluble
No
VV1_3098
27366366
SoxR-reducing system protein RsxE [Vibri...
230
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP92047
(
show subtarget assignments
)
8
selected
No
TGME49_047670
237835673
ribulose-phosphate 3-epimerase [Toxoplas...
230
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3OVP
50%
Toxoplasma gondii
IDP00868
(
show subtarget assignments
)
1
expressed
No
STM4171
16767425
yjaH
putative inner membrane protein
230
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Cell envelope
Other
IDP04579
(
show subtarget assignments
)
1
cloned
No
BAS0098
49183132
50S ribosomal protein L1 [Bacillus anthr...
230
Proposed to be essential proteins
Phase 4: April 2009
3QOY
56.3%
Bacillus anthracis
IDP00811
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1873
57284794
epiF
epidermin immunity protein F
230
Conserved Gene / Pathway
Phase 2: March 2008
2IT1
33.6%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP90561
(
show subtarget assignments
)
8
cloned
No
YPO1391
16121671
cmk
cytidylate kinase [Yersinia pestis CO92]...
230
Predicted Essential
Community Requests
1KDO
83%
Yersinia pestis
IDP01352
(
show subtarget assignments
)
1
soluble
No
VCA0447
15601210
haemagglutinin associated protein
230
Conserved Gene / Pathway
Phase 2: March 2008
1G60
29.5%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP91945
(
show subtarget assignments
)
8
selected
No
SpneCM_010100006704
298255282
Cps19aC [Streptococcus pneumoniae str. C...
230
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP00639
(
show subtarget assignments
)
1
cloned
No
SACOL0114
57286663
capsular polysaccharide biosynthesis gly...
230
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP92551
(
show subtarget assignments
)
8
selected
No
YP_001527882
158516893
unnamed protein product [West Nile virus...
231
potential drug target /
This protein is interesting for several reasons. First that it may prevent prope...
Community Requests
West Nile
IDP04122
(
show subtarget assignments
)
1
in_pdb
3OJC
Yes
YPO2758
115348441
putative aspartate/glutamate racemase [Y...
231
conserved gene; putative drug target function;
Phase 4: April 2009
3OJC
100%
Yersinia pestis
Amino acid biosynthesis
Aspartate family
IDP02684
(
show subtarget assignments
)
1
cloned
No
FTT0405
56707554
lolD
lipoprotein releasing system, subunit D,...
231
Conserved; Drug target functions
Phase 3: June 2008
1F3O
44.6%
Francisella tularensis
Transport and binding proteins
Unknown substrate
IDP92090
(
show subtarget assignments
)
8
selected
No
TGME49_121570
237844801
(3R)-hydroxymyristoyl ACP dehydrase, put...
231
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1Z6B
35.9%
Toxoplasma gondii
IDP05056
(
show subtarget assignments
)
1
soluble
No
CD0257
126697829
motB
chemotaxis protein [Clostridium difficil...
231
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2K1S
20.3%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP91279
(
show subtarget assignments
)
8
soluble
No
NT05BA4913
49181643
DNA-binding response regulator [Bacillus...
231
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
2OQR
32%
Bacillus anthracis
IDP90525
(
show subtarget assignments
)
8
in_pdb
3UWQ
3LDV
No
VC1911
15641913
orotidine 5'-phosphate decarboxylase [Vi...
231
Predicted Essential
Community Requests
3LDV
100%
Vibrio cholerae
IDP05459
(
show subtarget assignments
)
1
cloned
No
BA_0873
30254623
conserved domain protein [Bacillus anthr...
231
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP00071
(
show subtarget assignments
)
0
work_stopped
No
NT01ST2260
16420352
yeaZ
putative molecular chaperone
231
Essential
Phase 1: October 2007
2GEL
100%
Salmonella enterica
Unknown function
General
IDP04535
(
show subtarget assignments
)
8
selected
No
CAC05816
12329085
mxiN
MxiN, putative component of the Mxi-Spa ...
231
Shigella effector protein
Community Requests
Shigella flexneri
IDP91180
(
show subtarget assignments
)
8
cloned
No
CT576
15605305
lcrH_1
low calcium response protein H [Chlamydi...
232
virulence/pathogenesis /
Targets that are in a network of interactions with CT670 and CT671. These protei...
Community Requests
2VGX
19%
Chlamydia trachomatis
IDP00952
(
show subtarget assignments
)
1
purified
No
STM1176
16764532
flgD
flagellar basal body rod modification pr...
232
Conserved Gene / Pathway
Phase 2: March 2008
3C12
19.8%
Salmonella enterica
Cell envelope
Surface structures
IDP91143
(
show subtarget assignments
)
8
in_pdb
3R2T
Yes
SAOUHSC_00393
88194188
superantigen-like protein [Staphylococcu...
232
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3R2T
100%
Staphylococcus aureus
IDP04420
(
show subtarget assignments
)
1
cloned
No
GBAA3308
47528594
sdhB-1
l-serine dehydratase, iron-sulfur-depend...
232
virulence factor; putative drug target function;
Phase 4: April 2009
2IQQ
15.5%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP01716
(
show subtarget assignments
)
1
cloned
No
Cj0687c
15792036
flgH
flagellar basal body L-ring protein [Cam...
232
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP00770
(
show subtarget assignments
)
8
in_pdb
3R2I
No
SACOL0473
57285500
superantigen-like protein
232
Virulence Associated Factor
Community Requests
3R2I
100%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP02057
(
show subtarget assignments
)
1
soluble
No
Cj1311
15792634
neuA2
acylneuraminate cytidylyltransferase [Ca...
232
Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...
Phase 3: June 2008
1QWJ
26.3%
Campylobacter jejuni
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01349
(
show subtarget assignments
)
1
purified
No
VCA0253
15601021
antibiotic acetyltransferase
232
Drug Target Function
Phase 2: March 2008
3EEV
37.1%
Vibrio cholerae
Cellular processes
Toxin production and resistance
IDP91565
(
show subtarget assignments
)
8
expressed
No
BAB34273
13360309
ECs0850
hypothetical protein [Escherichia coli O...
232
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP90579
(
show subtarget assignments
)
8
soluble
No
VC0528
15640550
ispD
2-C-methyl-D-erythritol 4-phosphate cyti...
232
We have identified the methylerythritol phosphate (MEP) pathway enzymes, novel d...
Community Requests
1H3M
53.9%
Vibrio cholerae
IDP91047
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFA0003
5353563
vanRD
response regulator [Enterococcus faecium...
232
drug resistance /
Component of regulatory system of transcription of vancomycin resistance genes
Community Requests
2GWR
37.1%
Enterococcus faecium
IDP04604
(
show subtarget assignments
)
1
cloned
No
BAS3678
49186677
30S ribosomal protein S2 [Bacillus anthr...
233
Proposed to be essential proteins
Phase 4: April 2009
1FJG
56.2%
Bacillus anthracis
IDP00958
(
show subtarget assignments
)
1
soluble
No
STM1218
16764573
lolD
lipoprotein transporter ATP-binding subu...
233
Conserved Gene / Pathway
Phase 2: March 2008
2PCJ
43.3%
Salmonella enterica
Transport and binding proteins
Unknown substrate
IDP90619
(
show subtarget assignments
)
8
soluble
No
Cj1701c
15793004
rpsC
30S ribosomal protein S3 [Campylobacter ...
233
Predicted Essential
Community Requests
1VS5
56.7%
Campylobacter jejuni
IDP05057
(
show subtarget assignments
)
1
cloned
No
CD0266
126697838
fliA
RNA polymerase sigma factor for flagella...
233
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1RP3
38.2%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP90930
(
show subtarget assignments
)
8
cloned
No
YPO3384
16123533
mtn
5'-methylthioadenosine/S-adenosylhomocys...
233
Predicted Essential
Community Requests
1JYS
74.7%
Yersinia pestis
IDP91360
(
show subtarget assignments
)
8
cloned
No
VV1_2843
27366125
16S rRNA uridine-516 pseudouridylate syn...
233
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1KSK
55.4%
Vibrio vulnificus
IDP04254
(
show subtarget assignments
)
1
cloned
No
CPF_1823
110798846
putative lipoprotein [Clostridium perfri...
233
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cell envelope
Other
IDP01424
(
show subtarget assignments
)
1
purified
No
VC1568
15641576
ABC transporter, ATP-binding protein
233
Conserved Gene / Pathway
Phase 2: March 2008
1F3O
49.8%
Vibrio cholerae
Transport and binding proteins
Unknown substrate
IDP00715
(
show subtarget assignments
)
1
cloned
No
SACOL1414
57286065
peptide ABC transporter, ATP-binding pro...
233
Conserved Gene / Pathway
Phase 2: March 2008
3QF4
30.8%
Staphylococcus aureus
Transport and binding proteins
Amino acids, peptides and amines
IDP02194
(
show subtarget assignments
)
1
expressed
No
FTT0075
56707254
sdhB
succinate dehydrogenase iron-sulfur subu...
233
Conserved; Drug target functions
Phase 3: June 2008
1NEK
66.7%
Francisella tularensis
Energy metabolism
TCA cycle
IDP01360
(
show subtarget assignments
)
1
purified
No
VC0148
15640179
cell division ATP-binding protein FtsE
233
Conserved Gene / Pathway
Phase 2: March 2008
2PCJ
35.6%
Vibrio cholerae
Cellular processes
Cell division
IDP02713
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0064
16802112
hypothetical protein lmo0064 [Listeria m...
233
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
Listeria monocytogenes
No Data
No Data
IDP05296
(
show subtarget assignments
)
1
purified
No
CD2138
126699755
pyrH
uridylate kinase [Clostridium difficile ...
234
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1Z9D
59.1%
Clostridium difficile
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
IDP90650
(
show subtarget assignments
)
8
expressed
No
Cj0713
15792062
trmD
tRNA (guanine-N(1)-)-methyltransferase [...
234
Predicted Essential
Community Requests
3KY7
38%
Campylobacter jejuni
IDP00058
(
show subtarget assignments
)
1
soluble
No
BA_3903
30258417
bacteriocin ABC transporter, ATP-binding...
234
Virulence
Phase 1: October 2007
1OXS
32.3%
Bacillus anthracis
Cellular processes
Toxin production and resistance
IDP91931
(
show subtarget assignments
)
8
expressed
No
SpneCM_010100007426
298255416
zinc transport system ATP-binding protei...
234
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3FVQ
30.8%
Streptococcus pneumoniae
IDP91908
(
show subtarget assignments
)
8
selected
No
SpneCM_010100007251
298255381
hypothetical protein SpneCM_07251 [Strep...
234
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91753
(
show subtarget assignments
)
8
selected
No
TSST_STAAU
0
234
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2IJ0
82.5%
Staphylococcus aureus
IDP02802
(
show subtarget assignments
)
1
cloned
No
GBAA3471
47528757
short chain dehydrogenase/reductase fami...
234
Conserved; Essential;
Phase 3: June 2008
1SNY
26.8%
Bacillus anthracis
Unknown function
Enzymes of unknown specificity
IDP91466
(
show subtarget assignments
)
8
soluble
No
VV1_0078
27363563
site-specific recombinase XerC [Vibrio v...
234
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1A0P
20.1%
Vibrio vulnificus
IDP05061
(
show subtarget assignments
)
1
cloned
No
CD1631
126699235
sodA
superoxide dismutase (Mn) [Clostridium d...
234
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2RCV
47%
Clostridium difficile
Cellular processes: Detoxification
IDP05037
(
show subtarget assignments
)
1
soluble
No
BA_1836
30256106
putative polysaccharide deacetylase [Bac...
234
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2C71
27.4%
Bacillus anthracis
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP00647
(
show subtarget assignments
)
1
selected
No
SACOL1657
57286179
enterotoxin type A, putative
234
Virulence Associated Factor
Phase 2: March 2008
1ESF
40.2%
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP05352
(
show subtarget assignments
)
1
soluble
No
CD2650
126700264
putative cell division protein [Clostrid...
234
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cellular processes: Cell division
IDP00117
(
show subtarget assignments
)
1
purified
No
NT01ST0298
16763632
yaeB
putative regulatory protein
235
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
1XQB
47.7%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP00877
(
show subtarget assignments
)
1
crystallized
No
STM3015
16766317
ygeA
putative racemase
235
Conserved Gene / Pathway
Phase 2: March 2008
3OJC
56.6%
Salmonella enterica
Amino acid biosynthesis
Aspartate family
IDP00876
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1814
16765155
minC
septum formation inhibitor
235
Conserved Gene / Pathway
Phase 2: March 2008
3GHF
46.4%
Salmonella enterica
Cellular processes
Cell division
IDP01775
(
show subtarget assignments
)
1
cloned
No
Cj1331
15792654
ptmB
acylneuraminate cytidylyltransferase (fl...
235
Known Predicted virulence-O-linked flagellar glycoslyation; Predicted Essential-...
Phase 3: June 2008
1EYR
28.9%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP04115
(
show subtarget assignments
)
1
expressed
No
STM2352_1_235
16765679
hisM
histidine/lysine/arginine/ornithine tran...
235
Salmonella essential protein
Phase 4: April 2009
3DHW
23.8%
Salmonella enterica
IDP01603
(
show subtarget assignments
)
1
cloned
No
STM1971
16765309
fliH
flagellar assembly protein H [Salmonella...
235
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP91043
(
show subtarget assignments
)
8
in_crystallization_trials
No
EFE0003
33355848
vanRG
response regulator [Enterococcus faecali...
235
drug resistance /
Component of regulatory system of transcription of vancomycin resistance genes
Community Requests
1P2F
37%
Enterococcus faecalis
IDP04024
(
show subtarget assignments
)
1
cloned
No
BAS5319
49188303
DNA-binding response regulator YycF [Bac...
235
Proposed to be essential proteins
Phase 4: April 2009
2OQR
47.7%
Bacillus anthracis
IDP04560
(
show subtarget assignments
)
1
in_pdb
3NUA
Yes
CPF_0673
110799762
purC
phosphoribosylaminoimidazole-succinocarb...
235
conserved gene; putative drug target function;
Phase 4: April 2009
3NUA
100%
Clostridium perfringens
Purines, pyrimidines, nucleosides, and nucleotides
Purine ribonucleotide biosynthesis
IDP90369
(
show subtarget assignments
)
8
cloned
No
CT_181
3328585
hypothetical protein [Chlamydia trachoma...
236
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP90788
(
show subtarget assignments
)
8
in_crystallization_trials
No
Cj0512
15791874
purC
phosphoribosylaminoimidazole-succinocarb...
236
Predicted Essential
Community Requests
3NUA
50.8%
Campylobacter jejuni
IDP05007
(
show subtarget assignments
)
1
cloned
No
BA_3383
30257926
putative lipoprotein [Bacillus anthracis...
236
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP92564
(
show subtarget assignments
)
8
selected
No
3L6P_A
290560467
Chain A, Crystal Structure Of Dengue Vir...
236
potential drug target /
Dengue plasmid entered for cocrystal studies with a small molecule West Nile pro...
Community Requests
3L6P
100%
Dengue virus
IDP92080
(
show subtarget assignments
)
8
selected
No
TGME49_105290
237842049
vacuolar ATP synthase subunit E, putativ...
236
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2DM9
25%
Toxoplasma gondii
IDP92072
(
show subtarget assignments
)
8
selected
No
TGME49_087210
237840039
proteasome subunit alpha type 2, putativ...
236
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3UNB
64%
Toxoplasma gondii
IDP00212
(
show subtarget assignments
)
1
expressed
No
YPO2123
16122358
-
putative phage minor tail protein
236
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP05128
(
show subtarget assignments
)
1
soluble
No
BA_5530
30259989
conserved hypothetical protein [Bacillus...
236
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2FPN
29.2%
Bacillus anthracis
Hypothetical proteins: Conserved
IDP91480
(
show subtarget assignments
)
8
expressed
No
VPA1327
28901182
putative exoenzyme T [Vibrio parahaemoly...
236
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP01445
(
show subtarget assignments
)
1
soluble
No
VC2088
15642088
sdhB
succinate dehydrogenase iron-sulfur subu...
236
Conserved Gene / Pathway
Phase 2: March 2008
1NEK
77.2%
Vibrio cholerae
Energy metabolism
TCA cycle
IDP90380
(
show subtarget assignments
)
8
expressed
No
CT_311
3328727
hypothetical protein [Chlamydia trachoma...
236
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP01319
(
show subtarget assignments
)
1
soluble
No
VC0312
15640339
fre
FMN reductase
236
Conserved Gene / Pathway
Phase 2: March 2008
1QFJ
48.3%
Vibrio cholerae
Energy metabolism
Electron transport
IDP05421
(
show subtarget assignments
)
1
soluble
No
BAS1418
49184435
-
hypothetical protein BAS1418 [Bacillus a...
237
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
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