Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00656 (show subtarget assignments)	1	cloned	No	SACOL0543	57284226	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	450	Drug Target Function	Phase 2: March 2008	1G95	49.1%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01252 (show subtarget assignments)	1	cloned	No	BA_5623	30260075		penicillin-binding protein	683	Drug Target Function	Phase 2: March 2008	3UDF	28.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251 (show subtarget assignments)	1	cloned	No	BA_4606	30259106		penicillin-binding protein	584	Drug Target Function	Phase 2: March 2008	3OC2	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250 (show subtarget assignments)	1	cloned	No	BA_4497	30259003		penicillin-binding protein	706	Drug Target Function	Phase 2: March 2008	2WAF	33%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249 (show subtarget assignments)	1	cloned	No	BA_4055	30258562		penicillin-binding protein	716	Drug Target Function	Phase 2: March 2008	1QME	30.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01248 (show subtarget assignments)	1	soluble	No	BA_3554	30258085		penicillin-binding protein, putative	377	Drug Target Function	Phase 2: March 2008	3TG9	23.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01247 (show subtarget assignments)	1	soluble	No	BA_3214	30257780		penicillin-binding protein, putative	691	Drug Target Function	Phase 2: March 2008	2QMI	14.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00652 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0151	57285354	cap5P	UDP-N-acetylglucosamine 2-epimerase Cap5...	391	Conserved Gene / Pathway	Phase 2: March 2008	1O6C	56%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01246 (show subtarget assignments)	1	cloned	No	BA_2648	30257265		penicillin-binding protein	712	Drug Target Function	Phase 2: March 2008	1QME	29.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245 (show subtarget assignments)	1	cloned	No	BA_2637	30257254		penicillin-binding protein	708	Drug Target Function	Phase 2: March 2008	2WAD	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00651 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0143	57285346	cap5H	capsular polysaccharide biosynthesis pro...	208	Conserved Gene / Pathway	Phase 2: March 2008	3EEV	33.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01244 (show subtarget assignments)	1	cloned	No	BA_2504	30257132		penicillin-binding protein	588	Drug Target Function	Phase 2: March 2008	1MWR	23.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243 (show subtarget assignments)	1	cloned	No	BA_2345	30256982		penicillin-binding protein 1A	820	Drug Target Function	Phase 2: March 2008	2OLU	29.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00906 (show subtarget assignments)	0	work_stopped	No	STM0129	16763519	murC	UDP-N-acetylmuramate--L-alanine ligase	491	Essential Gene	Phase 2: March 2008	2F00	94.5%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00650 (show subtarget assignments)	1	soluble	No	SACOL0113	57286662		NAD-dependent epimerase/dehydratase fami...	323	Conserved Gene / Pathway	Phase 2: March 2008	1SB8	36.2%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01242 (show subtarget assignments)	1	soluble	No	BA_1572	30255873		penicillin-binding protein	897	Drug Target Function	Phase 2: March 2008	2OLU	27.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01241 (show subtarget assignments)	1	expressed	No	BA_1474	30255405		penicillin-binding protein	673	Drug Target Function	Phase 2: March 2008	2JCH	28.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01240 (show subtarget assignments)	1	cloned	No	BA_1069	30254800	pbpF	penicillin-binding protein 1	705	Drug Target Function	Phase 2: March 2008	2OLU	27.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01239 (show subtarget assignments)	1	cloned	No	BA_5670	30260118		glycosyl transferase, group 1 family pro...	366	Drug Target Function	Phase 2: March 2008	2JJM	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02590 (show subtarget assignments)	1	soluble	No	FTT0831c	56707940		OmpA family protein [Francisella tularen...	417	Drug Target	Phase 3: June 2008	2K1S	11%	Francisella tularensis	Cell envelope	Other

IDP01236 (show subtarget assignments)	1	expressed	No	BA_5514	30259974		glycosyl transferase, group 1 family pro...	550	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01235 (show subtarget assignments)	1	purified	No	BA_5512	30259972	wecC	UDP-N-acetyl-D-mannosamine dehydrogenase...	427	Drug Target Function	Phase 2: March 2008	3OJL	62.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00320 (show subtarget assignments)	1	expressed	No	CBU_0550	29653890	pbpA	penicillin-binding protein 2	612	Drug Target Function	Phase 2: March 2008	1MWR	25.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01234 (show subtarget assignments)	0	work_stopped	No	BA_5509	30259969		UDP-N-acetylglucosamine 2-epimerase	371	Drug Target Function	Phase 2: March 2008	3BEO	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01231 (show subtarget assignments)	1	purified	No	BA_4684	30259179	mreB	rod shape-determining protein MreB	339	Drug Target Function	Phase 2: March 2008	1JCE	52.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02586 (show subtarget assignments)	1	cloned	No	Cj1478c	15792793	cadF	fibronectin-binding protein [Campylobact...	319	Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...	Phase 3: June 2008	3NB3	24.5%	Campylobacter jejuni	Cell envelope	Other

IDP00318 (show subtarget assignments)	1	cloned	No	CBU_1947	29655231	glmU	UDP-N-acetylglucosamine pyrophosphorylas...	455	Drug Target Function	Phase 2: March 2008	1HV9	51.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02593 (show subtarget assignments)	1	expressed	No	YPO3426	16123575	hofB	hypothetical protein YPO3426 [Yersinia p...	512	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	34.2%	Yersinia pestis	Cell envelope	Surface structures

IDP00317 (show subtarget assignments)	1	cloned	No	CBU_1887	29655172	ponA	penicillin-binding protein 1A	793	Drug Target Function	Phase 2: March 2008	3UDF	40.4%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02035 (show subtarget assignments)	1	cloned	No	Cj1141	15792466	neuB1	N-acetylneuraminic acid synthetase [Camp...	343	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1XUU	59%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01224 (show subtarget assignments)	1	cloned	No	BA_4054	30258561		sporulation specific penicillin-binding ...	638	Drug Target Function	Phase 2: March 2008	1PYY	26.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01223 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4051	60390084		UDP-N-acetylmuramoylalanine--D-glutamate...	450	Conserved Gene / Pathway	Phase 2: March 2008	3LK7	52.7%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00639 (show subtarget assignments)	1	cloned	No	SACOL0114	57286663		capsular polysaccharide biosynthesis gly...	230	Conserved Gene / Pathway	Phase 2: March 2008			Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01222 (show subtarget assignments)	1	purified	No	BA_4049	33301352		UDP-N-acetylglucosamine--N-acetylmuramyl...	364	Drug Target Function	Phase 2: March 2008	1F0K	31.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01219 (show subtarget assignments)	1	purified	No	BA_3767	30258283		prophage LambdaBa01, N-acetylmuramoyl-L-...	310	Drug Target Function	Phase 2: March 2008	2L47	40.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01217 (show subtarget assignments)	1	expressed	No	BA_3695	30258216		S-layer protein, putative	510	Drug Target Function	Phase 2: March 2008	3PYW	10.2%	Bacillus anthracis	Cell envelope	Surface structures

IDP04712 (show subtarget assignments)	1	cloned	No	YPO0514	115346324		putative OmpA-family membrane protein [Y...	536	virulence factor; putative drug target function;	Phase 4: April 2009	2L26	9%	Yersinia pestis	Cell envelope	Other

IDP01216 (show subtarget assignments)	1	expressed	No	BA_3577	30258105		glycosyl transferase, group 1 family pro...	270	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01215 (show subtarget assignments)	1	expressed	No	BA_3506	30258044		penicillin-binding protein, putative	345	Drug Target Function	Phase 2: March 2008	2QMI	25.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02585 (show subtarget assignments)	1	purified	No	FTT1416c	56708463		lipoprotein [Francisella tularensis subs...	137	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP00314 (show subtarget assignments)	1	expressed	No	CBU_0751	29654085	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	434	Drug Target Function	Phase 2: March 2008	1EJC	57.1%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01212 (show subtarget assignments)	1	expressed	No	BA_3024	30257611		glycosyl transferase, group 2 family pro...	490	Essential Gene	Phase 2: March 2008	3E25	9.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01210 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2805	30257409		glycosyl hydrolase, family 25, putative ...	268	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	61.9%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01209 (show subtarget assignments)	1	soluble	No	BA_2650	30257267		penicillin-binding protein	340	Drug Target Function	Phase 2: March 2008	3TG9	53.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01208 (show subtarget assignments)	1	expressed	No	BA_2638	30257255		glycosyl transferase, putative	387	Essential Gene	Phase 2: March 2008	2IYA	26.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01207 (show subtarget assignments)	1	in_pdb 3R5X 3R23	Yes	BA_2610	39930865		D-alanine--D-alanine ligase (D-alanylala...	304	Conserved Gene / Pathway	Phase 2: March 2008	3R23	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01206 (show subtarget assignments)	1	purified	No	BA_2446	30257076		N-acetylmuramoyl-L-alanine amidase, fami...	245	Conserved Gene / Pathway	Phase 2: March 2008	1XOV	26.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04392 (show subtarget assignments)	1	cloned	No	CPF_1500	110798925		putative lipoprotein [Clostridium perfri...	202	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01204 (show subtarget assignments)	1	crystallized	No	BA_2274	30256914		glycosyl transferase, group 2 family pro...	406	Essential Gene	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01203 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2083	30256732		glycosyltransferase, MGT family	402	Conserved Gene / Pathway	Phase 2: March 2008	3IAA	29.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04356 (show subtarget assignments)	1	cloned	No	YPO0509	115346318		hypothetical protein [Yersinia pestis CO...	540	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009	2XT4	9.3%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01202 (show subtarget assignments)	1	in_crystallization_trials	No	BA_2079	30256728	dal-2	alanine racemase	391	Drug Target Function	Phase 2: March 2008	3E5P	41.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01200 (show subtarget assignments)	1	cloned	No	BA_1707	30255995		transglycosylase, SLT family	261	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01197 (show subtarget assignments)	0	work_stopped	No	BA_1389	81715334		D-alanine--poly(phosphoribitol) ligase s...	503	Conserved Gene / Pathway	Phase 2: March 2008	3DHV	99.4%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01195 (show subtarget assignments)	1	in_pdb 3SC6	No	BA_1231	30255180	rfbD	dTDP-4-dehydrorhamnose reductase	284	Drug Target Function	Phase 2: March 2008	3SC6	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01194 (show subtarget assignments)	1	in_pdb 4EGB	No	BA_1230	30255179	rfbB	dTDP-glucose 4,6-dehydratase	322	Conserved Gene / Pathway	Phase 2: March 2008	4EGB	100%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02576 (show subtarget assignments)	1	purified	No	GBAA0246	47525503	murF	UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...	458	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2AM1	37.1%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00309 (show subtarget assignments)	1	expressed	No	CBU_0298	29653649	murI	glutamate racemase	280	Drug Target Function	Phase 2: March 2008	2GZM	38.2%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01190 (show subtarget assignments)	1	cloned	No	BA_0872	30254622		N-acetylmuramoyl-L-alanine amidase, fami...	348	Drug Target Function	Phase 2: March 2008	3HMB	25.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01189 (show subtarget assignments)	1	expressed	No	BA_0505	30254033		glycosyl transferase, group 2 family pro...	528	Drug Target Function	Phase 2: March 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00620 (show subtarget assignments)	1	cloned	No	SACOL0937	57285812	dltC	D-alanine--poly(phosphoribitol) ligase s...	78	Conserved Gene / Pathway	Phase 2: March 2008	1DV5	41%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01188 (show subtarget assignments)	1	expressed	No	BA_0502	30254030		penicillin-binding protein, putative	412	Drug Target Function	Phase 2: March 2008	2QMI	21.8%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01187 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0485	30254015		prophage LambdaBa04, glycosyl hydrolase,...	265	Conserved Gene / Pathway	Phase 2: March 2008	3HMC	71.3%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00134 (show subtarget assignments)	1	purified	No	VC_2250	9656811	VC2250	Vibrio cholerae O1 biovar eltor str. N16...	351	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3EH0	63%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02571 (show subtarget assignments)	1	expressed	No	Cj0549	15791910	fliS	flagellar protein FliS [Campylobacter je...	128	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3IQC	58.6%	Campylobacter jejuni	Cell envelope	Other

IDP01185 (show subtarget assignments)	1	cloned	No	BA_0280	30253775		glycosyl transferase, group 1 family pro...	443	Drug Target Function	Phase 2: March 2008	2JJM	13.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02368 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0422	56707569	murF	UDP-N--acetylmuramoylalanyl-D-glutamyl-2...	452	Conserved; Drug target functions	Phase 3: June 2008	1GG4	33.6%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00307 (show subtarget assignments)	1	expressed	No	CBU_0142	29653500	lpxC	UDP-3-0-acyl N-acetylglucosamine deacety...	303	Drug Target Function	Phase 2: March 2008	2VES	65.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01179 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0048	81583548		Bifunctional protein glmU [Includes: UDP...	459	Drug Target Function	Phase 2: March 2008	1G95	51.6%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00306 (show subtarget assignments)	1	expressed	No	CBU_0137	29653495	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	316	Drug Target Function	Phase 2: March 2008	3TX1	34.8%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02075 (show subtarget assignments)	1	cloned	No	Cj0060c	15791452	fliM	flagellar motor switch protein FliM [Cam...	359	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	3SOH	17%	Campylobacter jejuni	Cell envelope	Surface structures

IDP00305 (show subtarget assignments)	1	cloned	No	CBU_0118	29653476	pbpB	penicillin-binding protein 3	548	Drug Target Function	Phase 2: March 2008	3OC2	45.3%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02570 (show subtarget assignments)	1	cloned	No	Cj1339c	15792662	flaA	flagellin [Campylobacter jejuni subsp. j...	572	Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066	Phase 3: June 2008	1UCU	28%	Campylobacter jejuni	Cell envelope	Surface structures

IDP04354 (show subtarget assignments)	1	expressed	No	YPCD1.44	5832464	YPCD1.44	putative Yop secretion membrane protein ...	217	virulence factor; conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Cell envelope	Surface structures

IDP02579 (show subtarget assignments)	1	cloned	No	Cj1131c	15792456	galE	UDP-glucose 4-epimerase [Campylobacter j...	328	Predicted virulence-Posttranslational modification	Phase 3: June 2008	2C20	41.5%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01935 (show subtarget assignments)	1	expressed	No	CBU_0136	29540756	murC	UDP-N-acetylmuramate--alanine ligase [Co...	465	Conserved; Drug target functions	Phase 3: June 2008	2F00	47.7%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04682 (show subtarget assignments)	1	cloned	No	GBAA3189	47528481		adhesion lipoprotein [Bacillus anthracis...	311	virulence factor; putative drug target function;	Phase 4: April 2009	3HH8	49.8%	Bacillus anthracis	Cell envelope	Other

IDP02037 (show subtarget assignments)	1	cloned	No	CBU_0135	29540755	murG	UDP-N-acetylglucosamine--N-acetylmuramyl...	358	Conserved; Drug target functions	Phase 3: June 2008	1F0K	46.6%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04565 (show subtarget assignments)	1	cloned	No	CPF_1805	110798813		putative lipoprotein [Clostridium perfri...	281	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP00607 (show subtarget assignments)	1	soluble	No	SACOL2116	57286332	murAB	UDP-N-acetylglucosamine 1-carboxyvinyltr...	419	Drug Target Function	Phase 2: March 2008	3SG1	47%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04567 (show subtarget assignments)	1	cloned	No	CPF_2099	110800052		putative lipoprotein [Clostridium perfri...	343	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP04566 (show subtarget assignments)	1	expressed	No	CPF_1876	110800623		putative lipoprotein [Clostridium perfri...	221	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP02067 (show subtarget assignments)	1	purified	No	FTT0825c	56707936		hypothetical protein FTT0825c [Francisel...	111	Drug Target	Phase 3: June 2008			Francisella tularensis	Cell envelope	Other

IDP01152 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5520	30259980	mbl	mbl protein	333	Conserved Gene / Pathway	Phase 2: March 2008	1JCE	50.5%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01151 (show subtarget assignments)	0	work_stopped	No	BA_5433	30259901		UDP-N-acetylglucosamine 2-epimerase	371	Conserved Gene / Pathway	Phase 2: March 2008	3BEO	99.2%	Bacillus anthracis	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01929 (show subtarget assignments)	1	cloned	No	lmo1076	16803116		hypothetical protein lmo1076 [Listeria m...	572	Known virulence-Invasion; Possible Vaccine Candidate; PMID:15009888	Phase 3: June 2008	3FI7	31.5%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597 (show subtarget assignments)	1	purified	No	YPO3909	16124041	murI	glutamate racemase	287	Conserved Gene / Pathway	Phase 2: March 2008	2JFN	71.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02546 (show subtarget assignments)	1	expressed	No	Cj1143	15792468	neuA1	acylneuraminate cytidylyltransferase [Ca...	536	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1EYR	16.2%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00596 (show subtarget assignments)	1	purified	No	YPO0555	16120883	murG	N-acetylglucosaminyl transferase	356	Drug Target Function	Phase 2: March 2008	1F0K	78.4%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00595 (show subtarget assignments)	1	crystallized	No	YPO3760	16123897	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	345	Drug Target Function	Phase 2: March 2008	1MBB	60.9%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02548 (show subtarget assignments)	1	cloned	No	Cj0861c	15792199	pabA	para-aminobenzoate synthase glutamine am...	188	Possible Vaccine Candidate; Predicted Essential-Modeling	Phase 3: June 2008	1QDL	44%	Campylobacter jejuni	Cell envelope	Other

IDP00594 (show subtarget assignments)	0	work_stopped	No	YPO3569	16123713	murA	UDP-N-acetylglucosamine 1-carboxyvinyltr...	420	Conserved Gene / Pathway	Phase 2: March 2008	1NAW	91.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00592 (show subtarget assignments)	1	cloned	No	YPO3393	16123542	mrcB	penicillin-binding protein 1b	824	Virulence Associated Factor	Phase 2: March 2008	3VMA	66.7%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02544 (show subtarget assignments)	1	cloned	No	Cj1142	15792467	neuC1	putative N-acetylglucosamine-6-phosphate...	371	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	3OT5	21.6%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00591 (show subtarget assignments)	1	cloned	No	YPO0145	161486893	mrcA	penicillin-binding protein	859	Drug Target Function	Phase 2: March 2008	3UDF	36.2%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00590 (show subtarget assignments)	1	cloned	No	YPO1078	16121379	mltD	predicted membrane-bound lytic murein tr...	475	Drug Target Function	Phase 2: March 2008	1E0G	7.8%	Yersinia pestis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05556 (show subtarget assignments)	1	soluble	No	lmo1521	16803561	-	hypothetical protein lmo1521 [Listeria m...	427	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3NE8	17.1%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05542 (show subtarget assignments)	1	cloned	No	Cj0508	6967973	pbpA	hypothetical protein Cj0504c [Campylobac...	643	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	3FWL	31.1%	Campylobacter jejuni	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05742 (show subtarget assignments)	1	cloned	No	CD2655	126700269	murF	UDP-N-acetylmuramoyl-tripeptide--D-alany...	457	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1GG4	31.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05529 (show subtarget assignments)	1	cloned	No	CD2658	126700272	mraW	S-adenosyl-methyltransferase [Clostridiu...	318	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1WG8	41.2%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00656
(show subtarget assignments)

1

cloned

No

SACOL0543

57284226

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

450

Drug Target Function

Phase 2: March 2008

1G95

49.1%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01252
(show subtarget assignments)

1

cloned

No

BA_5623

30260075

penicillin-binding protein

683

Drug Target Function

Phase 2: March 2008

3UDF

28.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01251
(show subtarget assignments)

1

cloned

No

BA_4606

30259106

penicillin-binding protein

584

Drug Target Function

Phase 2: March 2008

3OC2

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01250
(show subtarget assignments)

1

cloned

No

BA_4497

30259003

penicillin-binding protein

706

Drug Target Function

Phase 2: March 2008

2WAF

33%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01249
(show subtarget assignments)

1

cloned

No

BA_4055

30258562

penicillin-binding protein

716

Drug Target Function

Phase 2: March 2008

1QME

30.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01248
(show subtarget assignments)

1

soluble

No

BA_3554

30258085

penicillin-binding protein, putative

377

Drug Target Function

Phase 2: March 2008

3TG9

23.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01247
(show subtarget assignments)

1

soluble

No

BA_3214

30257780

penicillin-binding protein, putative

691

Drug Target Function

Phase 2: March 2008

2QMI

14.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00652
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0151

57285354

cap5P

UDP-N-acetylglucosamine 2-epimerase Cap5...

391

Conserved Gene / Pathway

Phase 2: March 2008

1O6C

56%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01246
(show subtarget assignments)

1

cloned

No

BA_2648

30257265

penicillin-binding protein

712

Drug Target Function

Phase 2: March 2008

1QME

29.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01245
(show subtarget assignments)

1

cloned

No

BA_2637

30257254

penicillin-binding protein

708

Drug Target Function

Phase 2: March 2008

2WAD

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00651
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0143

57285346

cap5H

capsular polysaccharide biosynthesis pro...

208

Conserved Gene / Pathway

Phase 2: March 2008

3EEV

33.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01244
(show subtarget assignments)

1

cloned

No

BA_2504

30257132

penicillin-binding protein

588

Drug Target Function

Phase 2: March 2008

1MWR

23.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01243
(show subtarget assignments)

1

cloned

No

BA_2345

30256982

penicillin-binding protein 1A

820

Drug Target Function

Phase 2: March 2008

2OLU

29.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00906
(show subtarget assignments)

0

work_stopped

No

STM0129

16763519

murC

UDP-N-acetylmuramate--L-alanine ligase

491

Essential Gene

Phase 2: March 2008

2F00

94.5%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00650
(show subtarget assignments)

1

soluble

No

SACOL0113

57286662

NAD-dependent epimerase/dehydratase fami...

323

Conserved Gene / Pathway

Phase 2: March 2008

1SB8

36.2%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01242
(show subtarget assignments)

1

soluble

No

BA_1572

30255873

penicillin-binding protein

897

Drug Target Function

Phase 2: March 2008

2OLU

27.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01241
(show subtarget assignments)

1

expressed

No

BA_1474

30255405

penicillin-binding protein

673

Drug Target Function

Phase 2: March 2008

2JCH

28.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01240
(show subtarget assignments)

1

cloned

No

BA_1069

30254800

pbpF

penicillin-binding protein 1

705

Drug Target Function

Phase 2: March 2008

2OLU

27.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01239
(show subtarget assignments)

1

cloned

No

BA_5670

30260118

glycosyl transferase, group 1 family pro...

366

Drug Target Function

Phase 2: March 2008

2JJM

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02590
(show subtarget assignments)

1

soluble

No

FTT0831c

56707940

OmpA family protein [Francisella tularen...

417

Drug Target

Phase 3: June 2008

2K1S

11%

Francisella tularensis

Cell envelope

Other

IDP01236
(show subtarget assignments)

1

expressed

No

BA_5514

30259974

glycosyl transferase, group 1 family pro...

550

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01235
(show subtarget assignments)

1

purified

No

BA_5512

30259972

wecC

UDP-N-acetyl-D-mannosamine dehydrogenase...

427

Drug Target Function

Phase 2: March 2008

3OJL

62.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00320
(show subtarget assignments)

1

expressed

No

CBU_0550

29653890

pbpA

penicillin-binding protein 2

612

Drug Target Function

Phase 2: March 2008

1MWR

25.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01234
(show subtarget assignments)

0

work_stopped

No

BA_5509

30259969

UDP-N-acetylglucosamine 2-epimerase

371

Drug Target Function

Phase 2: March 2008

3BEO

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01231
(show subtarget assignments)

1

purified

No

BA_4684

30259179

mreB

rod shape-determining protein MreB

339

Drug Target Function

Phase 2: March 2008

1JCE

52.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02586
(show subtarget assignments)

1

cloned

No

Cj1478c

15792793

cadF

fibronectin-binding protein [Campylobact...

319

Known Predicted virulence-adherence; Predicted virulence-Adhesion of Campylobact...

Phase 3: June 2008

3NB3

24.5%

Campylobacter jejuni

Cell envelope

Other

IDP00318
(show subtarget assignments)

1

cloned

No

CBU_1947

29655231

glmU

UDP-N-acetylglucosamine pyrophosphorylas...

455

Drug Target Function

Phase 2: March 2008

1HV9

51.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02593
(show subtarget assignments)

1

expressed

No

YPO3426

16123575

hofB

hypothetical protein YPO3426 [Yersinia p...

512

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

34.2%

Yersinia pestis

Cell envelope

Surface structures

IDP00317
(show subtarget assignments)

1

cloned

No

CBU_1887

29655172

ponA

penicillin-binding protein 1A

793

Drug Target Function

Phase 2: March 2008

3UDF

40.4%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02035
(show subtarget assignments)

1

cloned

No

Cj1141

15792466

neuB1

N-acetylneuraminic acid synthetase [Camp...

343

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1XUU

59%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01224
(show subtarget assignments)

1

cloned

No

BA_4054

30258561

sporulation specific penicillin-binding ...

638

Drug Target Function

Phase 2: March 2008

1PYY

26.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01223
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4051

60390084

UDP-N-acetylmuramoylalanine--D-glutamate...

450

Conserved Gene / Pathway

Phase 2: March 2008

3LK7

52.7%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00639
(show subtarget assignments)

1

cloned

No

SACOL0114

57286663

capsular polysaccharide biosynthesis gly...

230

Conserved Gene / Pathway

Phase 2: March 2008

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01222
(show subtarget assignments)

1

purified

No

BA_4049

33301352

UDP-N-acetylglucosamine--N-acetylmuramyl...

364

Drug Target Function

Phase 2: March 2008

1F0K

31.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01219
(show subtarget assignments)

1

purified

No

BA_3767

30258283

prophage LambdaBa01, N-acetylmuramoyl-L-...

310

Drug Target Function

Phase 2: March 2008

2L47

40.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01217
(show subtarget assignments)

1

expressed

No

BA_3695

30258216

S-layer protein, putative

510

Drug Target Function

Phase 2: March 2008

3PYW

10.2%

Bacillus anthracis

Cell envelope

Surface structures

IDP04712
(show subtarget assignments)

1

cloned

No

YPO0514

115346324

putative OmpA-family membrane protein [Y...

536

virulence factor; putative drug target function;

Phase 4: April 2009

2L26

9%

Yersinia pestis

Cell envelope

Other

IDP01216
(show subtarget assignments)

1

expressed

No

BA_3577

30258105

glycosyl transferase, group 1 family pro...

270

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01215
(show subtarget assignments)

1

expressed

No

BA_3506

30258044

penicillin-binding protein, putative

345

Drug Target Function

Phase 2: March 2008

2QMI

25.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02585
(show subtarget assignments)

1

purified

No

FTT1416c

56708463

lipoprotein [Francisella tularensis subs...

137

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP00314
(show subtarget assignments)

1

expressed

No

CBU_0751

29654085

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

434

Drug Target Function

Phase 2: March 2008

1EJC

57.1%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01212
(show subtarget assignments)

1

expressed

No

BA_3024

30257611

glycosyl transferase, group 2 family pro...

490

Essential Gene

Phase 2: March 2008

3E25

9.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01210
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2805

30257409

glycosyl hydrolase, family 25, putative ...

268

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

61.9%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01209
(show subtarget assignments)

1

soluble

No

BA_2650

30257267

penicillin-binding protein

340

Drug Target Function

Phase 2: March 2008

3TG9

53.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01208
(show subtarget assignments)

1

expressed

No

BA_2638

30257255

glycosyl transferase, putative

387

Essential Gene

Phase 2: March 2008

2IYA

26.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01207
(show subtarget assignments)

1

in_pdb
3R5X
3R23

Yes

BA_2610

39930865

D-alanine--D-alanine ligase (D-alanylala...

304

Conserved Gene / Pathway

Phase 2: March 2008

3R23

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01206
(show subtarget assignments)

1

purified

No

BA_2446

30257076

N-acetylmuramoyl-L-alanine amidase, fami...

245

Conserved Gene / Pathway

Phase 2: March 2008

1XOV

26.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04392
(show subtarget assignments)

1

cloned

No

CPF_1500

110798925

putative lipoprotein [Clostridium perfri...

202

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01204
(show subtarget assignments)

1

crystallized

No

BA_2274

30256914

glycosyl transferase, group 2 family pro...

406

Essential Gene

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01203
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2083

30256732

glycosyltransferase, MGT family

402

Conserved Gene / Pathway

Phase 2: March 2008

3IAA

29.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP04356
(show subtarget assignments)

1

cloned

No

YPO0509

115346318

hypothetical protein [Yersinia pestis CO...

540

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

2XT4

9.3%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01202
(show subtarget assignments)

1

in_crystallization_trials

No

BA_2079

30256728

dal-2

alanine racemase

391

Drug Target Function

Phase 2: March 2008

3E5P

41.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01200
(show subtarget assignments)

1

cloned

No

BA_1707

30255995

transglycosylase, SLT family

261

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01197
(show subtarget assignments)

0

work_stopped

No

BA_1389

81715334

D-alanine--poly(phosphoribitol) ligase s...

503

Conserved Gene / Pathway

Phase 2: March 2008

3DHV

99.4%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01195
(show subtarget assignments)

1

in_pdb
3SC6

No

BA_1231

30255180

rfbD

dTDP-4-dehydrorhamnose reductase

284

Drug Target Function

Phase 2: March 2008

3SC6

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01194
(show subtarget assignments)

1

in_pdb
4EGB

No

BA_1230

30255179

rfbB

dTDP-glucose 4,6-dehydratase

322

Conserved Gene / Pathway

Phase 2: March 2008

4EGB

100%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02576
(show subtarget assignments)

1

purified

No

GBAA0246

47525503

murF

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...

458

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2AM1

37.1%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00309
(show subtarget assignments)

1

expressed

No

CBU_0298

29653649

murI

glutamate racemase

280

Drug Target Function

Phase 2: March 2008

2GZM

38.2%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01190
(show subtarget assignments)

1

cloned

No

BA_0872

30254622

N-acetylmuramoyl-L-alanine amidase, fami...

348

Drug Target Function

Phase 2: March 2008

3HMB

25.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01189
(show subtarget assignments)

1

expressed

No

BA_0505

30254033

glycosyl transferase, group 2 family pro...

528

Drug Target Function

Phase 2: March 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00620
(show subtarget assignments)

1

cloned

No

SACOL0937

57285812

dltC

D-alanine--poly(phosphoribitol) ligase s...

78

Conserved Gene / Pathway

Phase 2: March 2008

1DV5

41%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01188
(show subtarget assignments)

1

expressed

No

BA_0502

30254030

penicillin-binding protein, putative

412

Drug Target Function

Phase 2: March 2008

2QMI

21.8%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01187
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0485

30254015

prophage LambdaBa04, glycosyl hydrolase,...

265

Conserved Gene / Pathway

Phase 2: March 2008

3HMC

71.3%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00134
(show subtarget assignments)

1

purified

No

VC_2250

9656811

VC2250

Vibrio cholerae O1 biovar eltor str. N16...

351

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3EH0

63%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02571
(show subtarget assignments)

1

expressed

No

Cj0549

15791910

fliS

flagellar protein FliS [Campylobacter je...

128

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3IQC

58.6%

Campylobacter jejuni

Cell envelope

Other

IDP01185
(show subtarget assignments)

1

cloned

No

BA_0280

30253775

glycosyl transferase, group 1 family pro...

443

Drug Target Function

Phase 2: March 2008

2JJM

13.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP02368
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0422

56707569

murF

UDP-N--acetylmuramoylalanyl-D-glutamyl-2...

452

Conserved; Drug target functions

Phase 3: June 2008

1GG4

33.6%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00307
(show subtarget assignments)

1

expressed

No

CBU_0142

29653500

lpxC

UDP-3-0-acyl N-acetylglucosamine deacety...

303

Drug Target Function

Phase 2: March 2008

2VES

65.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01179
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0048

81583548

Bifunctional protein glmU [Includes: UDP...

459

Drug Target Function

Phase 2: March 2008

1G95

51.6%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00306
(show subtarget assignments)

1

expressed

No

CBU_0137

29653495

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

316

Drug Target Function

Phase 2: March 2008

3TX1

34.8%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02075
(show subtarget assignments)

1

cloned

No

Cj0060c

15791452

fliM

flagellar motor switch protein FliM [Cam...

359

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

3SOH

17%

Campylobacter jejuni

Cell envelope

Surface structures

IDP00305
(show subtarget assignments)

1

cloned

No

CBU_0118

29653476

pbpB

penicillin-binding protein 3

548

Drug Target Function

Phase 2: March 2008

3OC2

45.3%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02570
(show subtarget assignments)

1

cloned

No

Cj1339c

15792662

flaA

flagellin [Campylobacter jejuni subsp. j...

572

Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066

Phase 3: June 2008

1UCU

28%

Campylobacter jejuni

Cell envelope

Surface structures

IDP04354
(show subtarget assignments)

1

expressed

No

YPCD1.44

5832464

YPCD1.44

putative Yop secretion membrane protein ...

217

virulence factor; conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Cell envelope

Surface structures

IDP02579
(show subtarget assignments)

1

cloned

No

Cj1131c

15792456

galE

UDP-glucose 4-epimerase [Campylobacter j...

328

Predicted virulence-Posttranslational modification

Phase 3: June 2008

2C20

41.5%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01935
(show subtarget assignments)

1

expressed

No

CBU_0136

29540756

murC

UDP-N-acetylmuramate--alanine ligase [Co...

465

Conserved; Drug target functions

Phase 3: June 2008

2F00

47.7%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04682
(show subtarget assignments)

1

cloned

No

GBAA3189

47528481

adhesion lipoprotein [Bacillus anthracis...

311

virulence factor; putative drug target function;

Phase 4: April 2009

3HH8

49.8%

Bacillus anthracis

Cell envelope

Other

IDP02037
(show subtarget assignments)

1

cloned

No

CBU_0135

29540755

murG

UDP-N-acetylglucosamine--N-acetylmuramyl...

358

Conserved; Drug target functions

Phase 3: June 2008

1F0K

46.6%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04565
(show subtarget assignments)

1

cloned

No

CPF_1805

110798813

putative lipoprotein [Clostridium perfri...

281

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP00607
(show subtarget assignments)

1

soluble

No

SACOL2116

57286332

murAB

UDP-N-acetylglucosamine 1-carboxyvinyltr...

419

Drug Target Function

Phase 2: March 2008

3SG1

47%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04567
(show subtarget assignments)

1

cloned

No

CPF_2099

110800052

putative lipoprotein [Clostridium perfri...

343

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP04566
(show subtarget assignments)

1

expressed

No

CPF_1876

110800623

putative lipoprotein [Clostridium perfri...

221

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP02067
(show subtarget assignments)

1

purified

No

FTT0825c

56707936

hypothetical protein FTT0825c [Francisel...

111

Drug Target

Phase 3: June 2008

Francisella tularensis

Cell envelope

Other

IDP01152
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5520

30259980

mbl

mbl protein

333

Conserved Gene / Pathway

Phase 2: March 2008

1JCE

50.5%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01151
(show subtarget assignments)

0

work_stopped

No

BA_5433

30259901

UDP-N-acetylglucosamine 2-epimerase

371

Conserved Gene / Pathway

Phase 2: March 2008

3BEO

99.2%

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01929
(show subtarget assignments)

1

cloned

No

lmo1076

16803116

hypothetical protein lmo1076 [Listeria m...

572

Known virulence-Invasion; Possible Vaccine Candidate; PMID:15009888

Phase 3: June 2008

3FI7

31.5%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00597
(show subtarget assignments)

1

purified

No

YPO3909

16124041

murI

glutamate racemase

287

Conserved Gene / Pathway

Phase 2: March 2008

2JFN

71.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02546
(show subtarget assignments)

1

expressed

No

Cj1143

15792468

neuA1

acylneuraminate cytidylyltransferase [Ca...

536

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1EYR

16.2%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00596
(show subtarget assignments)

1

purified

No

YPO0555

16120883

murG

N-acetylglucosaminyl transferase

356

Drug Target Function

Phase 2: March 2008

1F0K

78.4%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00595
(show subtarget assignments)

1

crystallized

No

YPO3760

16123897

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

345

Drug Target Function

Phase 2: March 2008

1MBB

60.9%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02548
(show subtarget assignments)

1

cloned

No

Cj0861c

15792199

pabA

para-aminobenzoate synthase glutamine am...

188

Possible Vaccine Candidate; Predicted Essential-Modeling

Phase 3: June 2008

1QDL

44%

Campylobacter jejuni

Cell envelope

Other

IDP00594
(show subtarget assignments)

0

work_stopped

No

YPO3569

16123713

murA

UDP-N-acetylglucosamine 1-carboxyvinyltr...

420

Conserved Gene / Pathway

Phase 2: March 2008

1NAW

91.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00592
(show subtarget assignments)

1

cloned

No

YPO3393

16123542

mrcB

penicillin-binding protein 1b

824

Virulence Associated Factor

Phase 2: March 2008

3VMA

66.7%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02544
(show subtarget assignments)

1

cloned

No

Cj1142

15792467

neuC1

putative N-acetylglucosamine-6-phosphate...

371

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

3OT5

21.6%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP00591
(show subtarget assignments)

1

cloned

No

YPO0145

161486893

mrcA

penicillin-binding protein

859

Drug Target Function

Phase 2: March 2008

3UDF

36.2%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP00590
(show subtarget assignments)

1

cloned

No

YPO1078

16121379

mltD

predicted membrane-bound lytic murein tr...

475

Drug Target Function

Phase 2: March 2008

1E0G

7.8%

Yersinia pestis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05556
(show subtarget assignments)

1

soluble

No

lmo1521

16803561

-

hypothetical protein lmo1521 [Listeria m...

427

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3NE8

17.1%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05542
(show subtarget assignments)

1

cloned

No

Cj0508

6967973

pbpA

hypothetical protein Cj0504c [Campylobac...

643

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

3FWL

31.1%

Campylobacter jejuni

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05742
(show subtarget assignments)

1

cloned

No

CD2655

126700269

murF

UDP-N-acetylmuramoyl-tripeptide--D-alany...

457

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1GG4

31.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05529
(show subtarget assignments)

1

cloned

No

CD2658

126700272

mraW

S-adenosyl-methyltransferase [Clostridiu...

318

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1WG8

41.2%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan