Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP00565 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0281	16120620	hmuT	hemin-binding periplasmic protein	279	Conserved Gene / Pathway	Phase 2: March 2008	3MD9	91%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00118 (show subtarget assignments)	1	in_pdb 3MGA	No	NT01ST0713	16763963	fes	enterobactin/ferric enterobactin esteras...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3MGA	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00232 (show subtarget assignments)	1	cloned	No	YPO3480	16123626	-	conserved hypothetical protein	292	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01002 (show subtarget assignments)	1	in_pdb 3ERP	Yes	STM2406	16765732		putative oxidoreductase	332	Essential Gene	Phase 2: March 2008	3ERP	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP04234 (show subtarget assignments)	1	cloned	No	CPF_0807	110799166		iron compound ABC transporter, iron comp...	314	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HXP	29.3%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP00977 (show subtarget assignments)	1	expressed	No	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP02366 (show subtarget assignments)	1	expressed	No	YPO2061	16122300	znuA	high-affinity zinc transporter periplasm...	318	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...	Phase 3: June 2008	2OGW	63.5%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02347 (show subtarget assignments)	1	soluble	No	YPO1783	16122037	ftnA	ferritin [Yersinia pestis CO92]	169	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3QZ3	68.6%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00490 (show subtarget assignments)	1	cloned	No	YPO1537	16121810		putative iron-siderophore receptor	753	Conserved Gene / Pathway	Phase 2: March 2008	3EFM	36%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP04109 (show subtarget assignments)	1	crystallized	No	GBAA3100	47528393		copper homeostasis protein CutC, putativ...	225	virulence factor; putative drug target function;	Phase 4: April 2009	2BDQ	30.7%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP00924 (show subtarget assignments)	1	purified	No	STM0590	16763967	fepC	iron-enterobactin transporter ATP-bindin...	264	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	28.4%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00489 (show subtarget assignments)	1	purified	No	YPO1533	16121806		putative iron-siderophore transport syst...	282	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.4%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00917 (show subtarget assignments)	1	cloned	No	STM0355	16763735		putative copper chaperone	64	Conserved Gene / Pathway	Phase 2: March 2008	2K2P	39.1%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00912 (show subtarget assignments)	1	soluble	No	STM0193	16763583	fhuD	iron-hydroxamate transporter substrate-b...	296	Conserved Gene / Pathway	Phase 2: March 2008	1ESZ	75%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00897 (show subtarget assignments)	1	expressed	No	STM0771	16764135		putative ABC-type cobalamin/Fe3+-siderop...	258	Conserved Gene / Pathway	Phase 2: March 2008	2ONK	32.2%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP02155 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0239	16120577	trkA	potassium transporter peripheral membran...	458	Conserved; CD; Drug target functions	Phase 3: June 2008	1LSS	12.2%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00454 (show subtarget assignments)	1	expressed	No	YPO0133	16120476	feoA	ferrous iron transport protein A	75	Virulence Associated Factor	Phase 2: March 2008	2GCX	70.7%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02493 (show subtarget assignments)	1	soluble	No	YPO2048	16122287	cutC	copper homeostasis protein CutC [Yersini...	254	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1TWD	54.3%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP02803 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1960	16803999	fhuC	hypothetical protein lmo1960 [Listeria m...	274	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1B0U	28.5%	Listeria monocytogenes	Transport and binding proteins	Cations and iron carrying compounds

IDP01696 (show subtarget assignments)	1	cloned	No	CBU_1767	29542324	feoA	ferrous iron transport protein A [Coxiel...	78	Conserved; Drug target functions	Phase 3: June 2008	2GCX	38.5%	Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP00430 (show subtarget assignments)	1	purified	No	YPO2960	16123142	sfuC	iron(III)-transport ATP-binding protein ...	349	Virulence Associated Factor	Phase 2: March 2008	3FVQ	39.8%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00429 (show subtarget assignments)	1	purified	No	YPO2958	16123140	sfuA	iron(III)-binding periplasmic protein	339	Virulence Associated Factor	Phase 2: March 2008	1XVX	79.9%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01511 (show subtarget assignments)	1	expressed	No	VC0794	15640812		hypothetical protein VC0794	139	Conserved Gene / Pathway	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01509 (show subtarget assignments)	1	expressed	No	VC0549	15640571		oxaloacetate decarboxylase subunit gamma...	117	Drug Target Function	Phase 2: March 2008			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01484 (show subtarget assignments)	1	in_pdb 4EH1	No	VCA0183	15600953		nitric oxide dioxygenase	394	Conserved Gene / Pathway	Phase 2: March 2008	4EH1	61.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01479 (show subtarget assignments)	1	expressed	No	VCA0064	15600835		TonB system receptor, putative	713	Conserved Gene / Pathway	Phase 2: March 2008	1NQF	22.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04509 (show subtarget assignments)	1	selected	No	CPF_0440	110800446		iron compound ABC transporter, iron comp...	350	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2PT1	37.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP04408 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_1426	110798602		iron(III) ABC transporter, iron(III)-bin...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GFV	24.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP01444 (show subtarget assignments)	1	soluble	No	VC2081	15642081		zinc ABC transporter, periplasmic zinc-b...	297	Conserved Gene / Pathway	Phase 2: March 2008	2OGW	44.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01434 (show subtarget assignments)	1	purified	No	VC1944	15641946		PvcB protein	287	Conserved Gene / Pathway	Phase 2: March 2008	3EAT	46%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00725 (show subtarget assignments)	1	cloned	No	SACOL1919	57284837		transcriptional regulator, Fur family	148	Conserved Gene / Pathway	Phase 2: March 2008	2FE3	63.5%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP01421 (show subtarget assignments)	1	soluble	No	VC1544	15641552		tonB2 protein	206	Conserved Gene / Pathway	Phase 2: March 2008	2K9K	34%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00709 (show subtarget assignments)	1	purified	No	SACOL0798	57285759		iron compound ABC transporter, ATP-bindi...	253	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	31.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP01401 (show subtarget assignments)	1	purified	No	VC0773	15640792		vibriobactin-specific isochorismate synt...	395	Drug Target Function	Phase 2: March 2008	3OS6	44.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01400 (show subtarget assignments)	1	expressed	No	VC0772	15640791		vibriobactin-specific 2,3-dihydroxybenzo...	543	Conserved Gene / Pathway	Phase 2: March 2008	1MD9	51.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01399 (show subtarget assignments)	1	in_crystallization_trials	No	VC0771	15640790		vibriobactin-specific isochorismatase	293	Conserved Gene / Pathway	Phase 2: March 2008	2FQ1	44.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00707 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0704	57285674		iron compound ABC transporter, ATP-bindi...	265	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	30.6%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP01389 (show subtarget assignments)	1	purified	No	VC0610	15640630		iron(III) ABC transporter, ATP-binding p...	343	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	36.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01388 (show subtarget assignments)	1	soluble	No	VC0608	15640628		iron(III) ABC transporter, periplasmic i...	352	Conserved Gene / Pathway	Phase 2: March 2008	1Q35	55.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01366 (show subtarget assignments)	1	soluble	No	VC0202	15640232		iron(III) ABC transporter, periplasmic i...	319	Conserved Gene / Pathway	Phase 2: March 2008	1EFD	25.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01365 (show subtarget assignments)	1	purified	No	VC0201	15640231		iron(III) ABC transporter, ATP-binding p...	285	Conserved Gene / Pathway	Phase 2: March 2008	1JJ7	28.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01364 (show subtarget assignments)	1	expressed	No	VC0200	15640230		iron(III) compound receptor	718	Conserved Gene / Pathway	Phase 2: March 2008	3QLB	33.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01358 (show subtarget assignments)	1	in_pdb 3QZ3	Yes	VC0078	15640110		ferritin	181	Conserved Gene / Pathway	Phase 2: March 2008	3QZ3	100%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02461 (show subtarget assignments)	1	cloned	No	Cj0176c	15791563		putative lipoprotein [Campylobacter jeju...	43	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008			Campylobacter jejuni	Transport and binding proteins	Cations and iron carrying compounds

IDP00153 (show subtarget assignments)	1	expressed	No	VC0475	15640502	irgA	enterobactin receptor	652	Virulence	Phase 1: October 2007	2HDF	37.1%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01341 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0687	15601444	fbpC	ferric transporter ATP-binding subunit	351	Conserved Gene / Pathway	Phase 2: March 2008	1V43	38.7%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00149 (show subtarget assignments)	1	expressed	No	VCA0230	15600999	vctC	vibriobactin and enterobactin ABC transp...	254	Virulence	Phase 1: October 2007	2D62	28%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01324 (show subtarget assignments)	1	cloned	No	VCA0910	15601664		tonB1 protein	249	Conserved Gene / Pathway	Phase 2: March 2008	2GRX	27.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP01321 (show subtarget assignments)	1	purified	No	VC2082	15642082		zinc ABC transporter, ATP-binding protei...	262	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00148 (show subtarget assignments)	1	soluble	No	VCA0227	15600996	vctP	vibriobactin and enterobactin ABC transp...	333	Virulence	Phase 1: October 2007	3GFV	30.3%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00666 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL1096	57285882		TrkA potassium uptake family protein	220	Drug Target Function	Phase 2: March 2008	2HMS	36.4%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP01309 (show subtarget assignments)	1	purified	No	VC2078	15642078		ferrous iron transport protein A	76	Drug Target Function	Phase 2: March 2008	2K5I	34.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00147 (show subtarget assignments)	1	expressed	No	VC0780	15640799	vibD	vibriobactin synthase component D	261	Virulence	Phase 1: October 2007			Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00146 (show subtarget assignments)	1	soluble	No	VC0778	15640797	viuG	vibriobactin and enterobactin ABC transp...	358	Virulence	Phase 1: October 2007	2QI9	28.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00145 (show subtarget assignments)	1	expressed	No	VC0777	15640796	viuD	vibriobactin and enterobactin ABC transp...	350	Virulence	Phase 1: October 2007	2NQ2	30.6%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00144 (show subtarget assignments)	1	soluble	No	VC0776	15640795	viuP	vibriobactin and enterobactin ABC transp...	325	Virulence	Phase 1: October 2007	3R5S	91.4%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP00143 (show subtarget assignments)	1	soluble	No	VC0779	15640798	viuC	vibriobactin and enterobactin ABC transp...	279	Virulence	Phase 1: October 2007	1B0U	29%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02540 (show subtarget assignments)	1	cloned	No	CBU_1584	29542144	shaE	monovalent cation/proton antiporter subu...	115	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Transport and binding proteins	Cations and iron carrying compounds

IDP02175 (show subtarget assignments)	1	cloned	No	YPO3064	16123241	bcp	thioredoxin-dependent thiol peroxidase [...	157	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3DRN	36.9%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00611 (show subtarget assignments)	1	crystallized	No	SACOL1952	57286299		ferritins family protein	166	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	39.2%	Staphylococcus aureus	Transport and binding proteins	Cations and iron carrying compounds

IDP00588 (show subtarget assignments)	1	purified	No	YPO2077	16122316	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	87.8%	Yersinia pestis	Cellular processes	Cell division

IDP01122 (show subtarget assignments)	1	soluble	No	BA_4045	30258552	ftsZ	cell division protein FtsZ	386	Conserved Gene / Pathway	Phase 2: March 2008	2VAM	78.1%	Bacillus anthracis	Cellular processes	Cell division

IDP01114 (show subtarget assignments)	1	soluble	No	BA_4901	38502945		Septation ring formation regulator ezrA	570	Conserved Gene / Pathway	Phase 2: March 2008			Bacillus anthracis	Cellular processes	Cell division

IDP01070 (show subtarget assignments)	1	expressed	No	STM3949	16767219	xerC	site-specific tyrosine recombinase XerC ...	300	Drug Target Function	Phase 2: March 2008	1A0P	37.3%	Salmonella enterica	Cellular processes	Cell division

IDP01055 (show subtarget assignments)	1	crystallized	No	STM3371	16766666	maf	Maf-like protein	197	Conserved Gene / Pathway	Phase 2: March 2008	1EX2	43.7%	Salmonella enterica	Cellular processes	Cell division

IDP04305 (show subtarget assignments)	1	cloned	No	CPF_2386	110798631		ribonuclease [Clostridium perfringens AT...	480	conserved gene; putative drug target function;	Phase 4: April 2009	2BX2	27.7%	Clostridium perfringens	Cellular processes	Cell division

IDP04301 (show subtarget assignments)	1	soluble	No	CPF_2400	110800698	maf	Maf-like protein [Clostridium perfringen...	192	conserved gene; putative drug target function;	Phase 4: April 2009	2P5X	44.4%	Clostridium perfringens	Cellular processes	Cell division

IDP00549 (show subtarget assignments)	1	purified	No	YPO3814	16123948	ftsY	cell division protein	541	Conserved Gene / Pathway	Phase 2: March 2008	2YHS	63.7%	Yersinia pestis	Cellular processes	Cell division

IDP00547 (show subtarget assignments)	1	expressed	No	YPO3813	16123947	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	39.6%	Yersinia pestis	Cellular processes	Cell division

IDP02184 (show subtarget assignments)	1	expressed	No	CBU_1352	29541917	ftsH	ATP-dependent metalloprotease FtsH [Coxi...	647	Conserved; Drug target functions	Phase 3: June 2008	2CE7	41.6%	Coxiella burnetii	Cellular processes	Cell division

IDP00540 (show subtarget assignments)	1	purified	No	YPO2719	16122923	era	GTP-binding protein Era	303	Conserved Gene / Pathway	Phase 2: March 2008	1EGA	83.8%	Yersinia pestis	Cellular processes	Cell division

IDP04261 (show subtarget assignments)	1	cloned	No	CPF_2059	110798854	scpB	segregation and condensation protein B [...	195	conserved gene; putative drug target function;	Phase 4: April 2009	1T6S	28.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04265 (show subtarget assignments)	1	purified	No	CPF_2105	110800754		putative cell division protein DivIVA [C...	208	conserved gene; putative drug target function;	Phase 4: April 2009	2WUJ	12%	Clostridium perfringens	Cellular processes	Cell division

IDP04259 (show subtarget assignments)	1	cloned	No	CPF_2018	110799691	ftsZ	cell division protein FtsZ [Clostridium ...	381	conserved gene; putative drug target function;	Phase 4: April 2009	2VAM	58%	Clostridium perfringens	Cellular processes	Cell division

IDP00517 (show subtarget assignments)	1	soluble	No	YPMT1.71	16082863		hypothetical protein YPMT1.71	328	Conserved Gene / Pathway	Phase 2: March 2008			Yersinia pestis	Cellular processes	Cell division

IDP00975 (show subtarget assignments)	1	cloned	No	STM1815	16765156	minD	cell division inhibitor MinD	270	Conserved Gene / Pathway	Phase 2: March 2008	3Q9L	93.3%	Salmonella enterica	Cellular processes	Cell division

IDP04193 (show subtarget assignments)	1	cloned	No	CPF_2398	110799387	mreB	rod shape-determining protein MreB [Clos...	342	conserved gene; putative drug target function;	Phase 4: April 2009	1JCE	53.2%	Clostridium perfringens	Cellular processes	Cell division

IDP00954 (show subtarget assignments)	1	in_crystallization_trials	No	STM1189	16764544	maf	Maf-like protein	194	Essential Gene	Phase 2: March 2008	1EX2	31.4%	Salmonella enterica	Cellular processes	Cell division

IDP02004 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0994c	56708086		MRP like protein [Francisella tularensis...	286	Conserved; Drug target functions	Phase 3: June 2008	2PH1	35.3%	Francisella tularensis	Cellular processes	Cell division

IDP04257 (show subtarget assignments)	1	cloned	No	CPF_2008	110798819	engA	GTP-binding protein EngA [Clostridium pe...	438	conserved gene; putative drug target function;	Phase 4: April 2009	2HJG	54.3%	Clostridium perfringens	Cellular processes	Cell division

IDP02312 (show subtarget assignments)	1	expressed	No	GBAA2190	47778017		FtsK/SpoIIIE family protein [Bacillus an...	1342	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2IUT	7.4%	Bacillus anthracis	Cellular processes	Cell division

IDP04101 (show subtarget assignments)	1	purified	No	CPF_2392	110799105	minE	cell division topological specificity fa...	90	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP00915 (show subtarget assignments)	1	in_crystallization_trials	No	STM0236	16763626	tilS	tRNA(Ile)-lysidine synthetase	430	Drug Target Function	Phase 2: March 2008	1NI5	75.3%	Salmonella enterica	Cellular processes	Cell division

IDP02615 (show subtarget assignments)	1	expressed	No	GBAA4677	47529976		ribonuclease [Bacillus anthracis str. 'A...	458	Conserved; Drug target functions	Phase 3: June 2008	2BX2	27.7%	Bacillus anthracis	Cellular processes	Cell division

IDP04087 (show subtarget assignments)	1	cloned	No	CPF_2394	110799648	minC	septum formation inhibitor [Clostridium ...	211	conserved gene; putative drug target function;	Phase 4: April 2009	1HF2	29.7%	Clostridium perfringens	Cellular processes	Cell division

IDP01847 (show subtarget assignments)	1	soluble	No	GBAA5416	47530729	ftsE	cell division ABC transporter, ATP-bindi...	214	Conserved; Drug target functions	Phase 3: June 2008	3DHW	41.1%	Bacillus anthracis	Cellular processes	Cell division

IDP04093 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1907	218929023	irp5	yersiniabactin siderophore biosynthetic ...	525	drug target; virulence factor; conserved gene; putative drug target function;...	Phase 4: April 2009	1MD9	47.8%	Yersinia pestis	Cellular processes	Cell division

IDP04042 (show subtarget assignments)	1	cloned	No	CPF_0296	110798725		putative cell division ATP-binding prote...	228	conserved gene; putative drug target function;	Phase 4: April 2009	1F3O	40.6%	Clostridium perfringens	Cellular processes	Cell division

IDP01811 (show subtarget assignments)	1	expressed	No	FTT0908	56708009	parB	chromosome partition protein B [Francise...	304	Conserved; Drug target functions	Phase 3: June 2008	1VZ0	23.7%	Francisella tularensis	Cellular processes	Cell division

IDP00473 (show subtarget assignments)	1	cloned	No	YPO0107	16120454	ftsN	cell division protein FtsN	281	Conserved Gene / Pathway	Phase 2: March 2008	1UTA	15.3%	Yersinia pestis	Cellular processes	Cell division

IDP04036 (show subtarget assignments)	1	cloned	No	CPF_1970	110800938	smc	chromosome segregation protein SMC [Clos...	1185	conserved gene; putative drug target function;	Phase 4: April 2009	3AUX	8.2%	Clostridium perfringens	Cellular processes	Cell division

IDP04020 (show subtarget assignments)	1	cloned	No	CPF_2112	110800515		cell division protein FtsQ [Clostridium ...	248	conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cellular processes	Cell division

IDP04010 (show subtarget assignments)	1	cloned	No	CPF_2393	110798628	minD	septum site-determining protein MinD [Cl...	265	conserved gene; putative drug target function;	Phase 4: April 2009	3Q9L	43.4%	Clostridium perfringens	Cellular processes	Cell division

IDP00876 (show subtarget assignments)	1	in_crystallization_trials	No	STM1814	16765155	minC	septum formation inhibitor	235	Conserved Gene / Pathway	Phase 2: March 2008	3GHF	46.4%	Salmonella enterica	Cellular processes	Cell division

IDP00465 (show subtarget assignments)	1	cloned	No	YPO1062	16121362	tilS	tRNA(Ile)-lysidine synthetase	460	Virulence Associated Factor	Phase 2: March 2008	1NI5	52.8%	Yersinia pestis	Cellular processes	Cell division

IDP00865 (show subtarget assignments)	1	expressed	No	STM3570	16766856	ftsE	cell division protein FtsE	222	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	41.9%	Salmonella enterica	Cellular processes	Cell division

IDP02605 (show subtarget assignments)	1	cloned	No	YPO3502	16123648	hflB	ATP-dependent metalloprotease [Yersinia ...	644	Drug target motif; Conserved; CD; Drug target functions	Phase 3: June 2008	2DHR	40.7%	Yersinia pestis	Cellular processes	Cell division

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP00565
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0281

16120620

hmuT

hemin-binding periplasmic protein

279

Conserved Gene / Pathway

Phase 2: March 2008

3MD9

91%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00118
(show subtarget assignments)

1

in_pdb
3MGA

No

NT01ST0713

16763963

fes

enterobactin/ferric enterobactin esteras...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3MGA

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00232
(show subtarget assignments)

1

cloned

No

YPO3480

16123626

-

conserved hypothetical protein

292

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01002
(show subtarget assignments)

1

in_pdb
3ERP

Yes

STM2406

16765732

putative oxidoreductase

332

Essential Gene

Phase 2: March 2008

3ERP

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP04234
(show subtarget assignments)

1

cloned

No

CPF_0807

110799166

iron compound ABC transporter, iron comp...

314

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HXP

29.3%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP00977
(show subtarget assignments)

1

expressed

No

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP02366
(show subtarget assignments)

1

expressed

No

YPO2061

16122300

znuA

high-affinity zinc transporter periplasm...

318

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Involved in virulen...

Phase 3: June 2008

2OGW

63.5%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02347
(show subtarget assignments)

1

soluble

No

YPO1783

16122037

ftnA

ferritin [Yersinia pestis CO92]

169

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3QZ3

68.6%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00490
(show subtarget assignments)

1

cloned

No

YPO1537

16121810

putative iron-siderophore receptor

753

Conserved Gene / Pathway

Phase 2: March 2008

3EFM

36%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP04109
(show subtarget assignments)

1

crystallized

No

GBAA3100

47528393

copper homeostasis protein CutC, putativ...

225

virulence factor; putative drug target function;

Phase 4: April 2009

2BDQ

30.7%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP00924
(show subtarget assignments)

1

purified

No

STM0590

16763967

fepC

iron-enterobactin transporter ATP-bindin...

264

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

28.4%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00489
(show subtarget assignments)

1

purified

No

YPO1533

16121806

putative iron-siderophore transport syst...

282

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.4%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00917
(show subtarget assignments)

1

cloned

No

STM0355

16763735

putative copper chaperone

64

Conserved Gene / Pathway

Phase 2: March 2008

2K2P

39.1%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00912
(show subtarget assignments)

1

soluble

No

STM0193

16763583

fhuD

iron-hydroxamate transporter substrate-b...

296

Conserved Gene / Pathway

Phase 2: March 2008

1ESZ

75%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00897
(show subtarget assignments)

1

expressed

No

STM0771

16764135

putative ABC-type cobalamin/Fe3+-siderop...

258

Conserved Gene / Pathway

Phase 2: March 2008

2ONK

32.2%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP02155
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0239

16120577

trkA

potassium transporter peripheral membran...

458

Conserved; CD; Drug target functions

Phase 3: June 2008

1LSS

12.2%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00454
(show subtarget assignments)

1

expressed

No

YPO0133

16120476

feoA

ferrous iron transport protein A

75

Virulence Associated Factor

Phase 2: March 2008

2GCX

70.7%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02493
(show subtarget assignments)

1

soluble

No

YPO2048

16122287

cutC

copper homeostasis protein CutC [Yersini...

254

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1TWD

54.3%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP02803
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1960

16803999

fhuC

hypothetical protein lmo1960 [Listeria m...

274

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1B0U

28.5%

Listeria monocytogenes

Transport and binding proteins

Cations and iron carrying compounds

IDP01696
(show subtarget assignments)

1

cloned

No

CBU_1767

29542324

feoA

ferrous iron transport protein A [Coxiel...

78

Conserved; Drug target functions

Phase 3: June 2008

2GCX

38.5%

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP00430
(show subtarget assignments)

1

purified

No

YPO2960

16123142

sfuC

iron(III)-transport ATP-binding protein ...

349

Virulence Associated Factor

Phase 2: March 2008

3FVQ

39.8%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00429
(show subtarget assignments)

1

purified

No

YPO2958

16123140

sfuA

iron(III)-binding periplasmic protein

339

Virulence Associated Factor

Phase 2: March 2008

1XVX

79.9%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01511
(show subtarget assignments)

1

expressed

No

VC0794

15640812

hypothetical protein VC0794

139

Conserved Gene / Pathway

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01509
(show subtarget assignments)

1

expressed

No

VC0549

15640571

oxaloacetate decarboxylase subunit gamma...

117

Drug Target Function

Phase 2: March 2008

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01484
(show subtarget assignments)

1

in_pdb
4EH1

No

VCA0183

15600953

nitric oxide dioxygenase

394

Conserved Gene / Pathway

Phase 2: March 2008

4EH1

61.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01479
(show subtarget assignments)

1

expressed

No

VCA0064

15600835

TonB system receptor, putative

713

Conserved Gene / Pathway

Phase 2: March 2008

1NQF

22.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04509
(show subtarget assignments)

1

selected

No

CPF_0440

110800446

iron compound ABC transporter, iron comp...

350

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2PT1

37.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP04408
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_1426

110798602

iron(III) ABC transporter, iron(III)-bin...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GFV

24.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP01444
(show subtarget assignments)

1

soluble

No

VC2081

15642081

zinc ABC transporter, periplasmic zinc-b...

297

Conserved Gene / Pathway

Phase 2: March 2008

2OGW

44.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01434
(show subtarget assignments)

1

purified

No

VC1944

15641946

PvcB protein

287

Conserved Gene / Pathway

Phase 2: March 2008

3EAT

46%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00725
(show subtarget assignments)

1

cloned

No

SACOL1919

57284837

transcriptional regulator, Fur family

148

Conserved Gene / Pathway

Phase 2: March 2008

2FE3

63.5%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP01421
(show subtarget assignments)

1

soluble

No

VC1544

15641552

tonB2 protein

206

Conserved Gene / Pathway

Phase 2: March 2008

2K9K

34%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00709
(show subtarget assignments)

1

purified

No

SACOL0798

57285759

iron compound ABC transporter, ATP-bindi...

253

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

31.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP01401
(show subtarget assignments)

1

purified

No

VC0773

15640792

vibriobactin-specific isochorismate synt...

395

Drug Target Function

Phase 2: March 2008

3OS6

44.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01400
(show subtarget assignments)

1

expressed

No

VC0772

15640791

vibriobactin-specific 2,3-dihydroxybenzo...

543

Conserved Gene / Pathway

Phase 2: March 2008

1MD9

51.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01399
(show subtarget assignments)

1

in_crystallization_trials

No

VC0771

15640790

vibriobactin-specific isochorismatase

293

Conserved Gene / Pathway

Phase 2: March 2008

2FQ1

44.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00707
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0704

57285674

iron compound ABC transporter, ATP-bindi...

265

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

30.6%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP01389
(show subtarget assignments)

1

purified

No

VC0610

15640630

iron(III) ABC transporter, ATP-binding p...

343

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

36.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01388
(show subtarget assignments)

1

soluble

No

VC0608

15640628

iron(III) ABC transporter, periplasmic i...

352

Conserved Gene / Pathway

Phase 2: March 2008

1Q35

55.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01366
(show subtarget assignments)

1

soluble

No

VC0202

15640232

iron(III) ABC transporter, periplasmic i...

319

Conserved Gene / Pathway

Phase 2: March 2008

1EFD

25.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01365
(show subtarget assignments)

1

purified

No

VC0201

15640231

iron(III) ABC transporter, ATP-binding p...

285

Conserved Gene / Pathway

Phase 2: March 2008

1JJ7

28.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01364
(show subtarget assignments)

1

expressed

No

VC0200

15640230

iron(III) compound receptor

718

Conserved Gene / Pathway

Phase 2: March 2008

3QLB

33.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01358
(show subtarget assignments)

1

in_pdb
3QZ3

Yes

VC0078

15640110

ferritin

181

Conserved Gene / Pathway

Phase 2: March 2008

3QZ3

100%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02461
(show subtarget assignments)

1

cloned

No

Cj0176c

15791563

putative lipoprotein [Campylobacter jeju...

43

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

Campylobacter jejuni

Transport and binding proteins

Cations and iron carrying compounds

IDP00153
(show subtarget assignments)

1

expressed

No

VC0475

15640502

irgA

enterobactin receptor

652

Virulence

Phase 1: October 2007

2HDF

37.1%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01341
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0687

15601444

fbpC

ferric transporter ATP-binding subunit

351

Conserved Gene / Pathway

Phase 2: March 2008

1V43

38.7%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00149
(show subtarget assignments)

1

expressed

No

VCA0230

15600999

vctC

vibriobactin and enterobactin ABC transp...

254

Virulence

Phase 1: October 2007

2D62

28%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01324
(show subtarget assignments)

1

cloned

No

VCA0910

15601664

tonB1 protein

249

Conserved Gene / Pathway

Phase 2: March 2008

2GRX

27.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP01321
(show subtarget assignments)

1

purified

No

VC2082

15642082

zinc ABC transporter, ATP-binding protei...

262

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00148
(show subtarget assignments)

1

soluble

No

VCA0227

15600996

vctP

vibriobactin and enterobactin ABC transp...

333

Virulence

Phase 1: October 2007

3GFV

30.3%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00666
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL1096

57285882

TrkA potassium uptake family protein

220

Drug Target Function

Phase 2: March 2008

2HMS

36.4%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP01309
(show subtarget assignments)

1

purified

No

VC2078

15642078

ferrous iron transport protein A

76

Drug Target Function

Phase 2: March 2008

2K5I

34.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00147
(show subtarget assignments)

1

expressed

No

VC0780

15640799

vibD

vibriobactin synthase component D

261

Virulence

Phase 1: October 2007

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00146
(show subtarget assignments)

1

soluble

No

VC0778

15640797

viuG

vibriobactin and enterobactin ABC transp...

358

Virulence

Phase 1: October 2007

2QI9

28.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00145
(show subtarget assignments)

1

expressed

No

VC0777

15640796

viuD

vibriobactin and enterobactin ABC transp...

350

Virulence

Phase 1: October 2007

2NQ2

30.6%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00144
(show subtarget assignments)

1

soluble

No

VC0776

15640795

viuP

vibriobactin and enterobactin ABC transp...

325

Virulence

Phase 1: October 2007

3R5S

91.4%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP00143
(show subtarget assignments)

1

soluble

No

VC0779

15640798

viuC

vibriobactin and enterobactin ABC transp...

279

Virulence

Phase 1: October 2007

1B0U

29%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02540
(show subtarget assignments)

1

cloned

No

CBU_1584

29542144

shaE

monovalent cation/proton antiporter subu...

115

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Transport and binding proteins

Cations and iron carrying compounds

IDP02175
(show subtarget assignments)

1

cloned

No

YPO3064

16123241

bcp

thioredoxin-dependent thiol peroxidase [...

157

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3DRN

36.9%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00611
(show subtarget assignments)

1

crystallized

No

SACOL1952

57286299

ferritins family protein

166

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

39.2%

Staphylococcus aureus

Transport and binding proteins

Cations and iron carrying compounds

IDP00588
(show subtarget assignments)

1

purified

No

YPO2077

16122316

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

87.8%

Yersinia pestis

Cellular processes

Cell division

IDP01122
(show subtarget assignments)

1

soluble

No

BA_4045

30258552

ftsZ

cell division protein FtsZ

386

Conserved Gene / Pathway

Phase 2: March 2008

2VAM

78.1%

Bacillus anthracis

Cellular processes

Cell division

IDP01114
(show subtarget assignments)

1

soluble

No

BA_4901

38502945

Septation ring formation regulator ezrA

570

Conserved Gene / Pathway

Phase 2: March 2008

Bacillus anthracis

Cellular processes

Cell division

IDP01070
(show subtarget assignments)

1

expressed

No

STM3949

16767219

xerC

site-specific tyrosine recombinase XerC ...

300

Drug Target Function

Phase 2: March 2008

1A0P

37.3%

Salmonella enterica

Cellular processes

Cell division

IDP01055
(show subtarget assignments)

1

crystallized

No

STM3371

16766666

maf

Maf-like protein

197

Conserved Gene / Pathway

Phase 2: March 2008

1EX2

43.7%

Salmonella enterica

Cellular processes

Cell division

IDP04305
(show subtarget assignments)

1

cloned

No

CPF_2386

110798631

ribonuclease [Clostridium perfringens AT...

480

conserved gene; putative drug target function;

Phase 4: April 2009

2BX2

27.7%

Clostridium perfringens

Cellular processes

Cell division

IDP04301
(show subtarget assignments)

1

soluble

No

CPF_2400

110800698

maf

Maf-like protein [Clostridium perfringen...

192

conserved gene; putative drug target function;

Phase 4: April 2009

2P5X

44.4%

Clostridium perfringens

Cellular processes

Cell division

IDP00549
(show subtarget assignments)

1

purified

No

YPO3814

16123948

ftsY

cell division protein

541

Conserved Gene / Pathway

Phase 2: March 2008

2YHS

63.7%

Yersinia pestis

Cellular processes

Cell division

IDP00547
(show subtarget assignments)

1

expressed

No

YPO3813

16123947

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

39.6%

Yersinia pestis

Cellular processes

Cell division

IDP02184
(show subtarget assignments)

1

expressed

No

CBU_1352

29541917

ftsH

ATP-dependent metalloprotease FtsH [Coxi...

647

Conserved; Drug target functions

Phase 3: June 2008

2CE7

41.6%

Coxiella burnetii

Cellular processes

Cell division

IDP00540
(show subtarget assignments)

1

purified

No

YPO2719

16122923

era

GTP-binding protein Era

303

Conserved Gene / Pathway

Phase 2: March 2008

1EGA

83.8%

Yersinia pestis

Cellular processes

Cell division

IDP04261
(show subtarget assignments)

1

cloned

No

CPF_2059

110798854

scpB

segregation and condensation protein B [...

195

conserved gene; putative drug target function;

Phase 4: April 2009

1T6S

28.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04265
(show subtarget assignments)

1

purified

No

CPF_2105

110800754

putative cell division protein DivIVA [C...

208

conserved gene; putative drug target function;

Phase 4: April 2009

2WUJ

12%

Clostridium perfringens

Cellular processes

Cell division

IDP04259
(show subtarget assignments)

1

cloned

No

CPF_2018

110799691

ftsZ

cell division protein FtsZ [Clostridium ...

381

conserved gene; putative drug target function;

Phase 4: April 2009

2VAM

58%

Clostridium perfringens

Cellular processes

Cell division

IDP00517
(show subtarget assignments)

1

soluble

No

YPMT1.71

16082863

hypothetical protein YPMT1.71

328

Conserved Gene / Pathway

Phase 2: March 2008

Yersinia pestis

Cellular processes

Cell division

IDP00975
(show subtarget assignments)

1

cloned

No

STM1815

16765156

minD

cell division inhibitor MinD

270

Conserved Gene / Pathway

Phase 2: March 2008

3Q9L

93.3%

Salmonella enterica

Cellular processes

Cell division

IDP04193
(show subtarget assignments)

1

cloned

No

CPF_2398

110799387

mreB

rod shape-determining protein MreB [Clos...

342

conserved gene; putative drug target function;

Phase 4: April 2009

1JCE

53.2%

Clostridium perfringens

Cellular processes

Cell division

IDP00954
(show subtarget assignments)

1

in_crystallization_trials

No

STM1189

16764544

maf

Maf-like protein

194

Essential Gene

Phase 2: March 2008

1EX2

31.4%

Salmonella enterica

Cellular processes

Cell division

IDP02004
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0994c

56708086

MRP like protein [Francisella tularensis...

286

Conserved; Drug target functions

Phase 3: June 2008

2PH1

35.3%

Francisella tularensis

Cellular processes

Cell division

IDP04257
(show subtarget assignments)

1

cloned

No

CPF_2008

110798819

engA

GTP-binding protein EngA [Clostridium pe...

438

conserved gene; putative drug target function;

Phase 4: April 2009

2HJG

54.3%

Clostridium perfringens

Cellular processes

Cell division

IDP02312
(show subtarget assignments)

1

expressed

No

GBAA2190

47778017

FtsK/SpoIIIE family protein [Bacillus an...

1342

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2IUT

7.4%

Bacillus anthracis

Cellular processes

Cell division

IDP04101
(show subtarget assignments)

1

purified

No

CPF_2392

110799105

minE

cell division topological specificity fa...

90

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP00915
(show subtarget assignments)

1

in_crystallization_trials

No

STM0236

16763626

tilS

tRNA(Ile)-lysidine synthetase

430

Drug Target Function

Phase 2: March 2008

1NI5

75.3%

Salmonella enterica

Cellular processes

Cell division

IDP02615
(show subtarget assignments)

1

expressed

No

GBAA4677

47529976

ribonuclease [Bacillus anthracis str. 'A...

458

Conserved; Drug target functions

Phase 3: June 2008

2BX2

27.7%

Bacillus anthracis

Cellular processes

Cell division

IDP04087
(show subtarget assignments)

1

cloned

No

CPF_2394

110799648

minC

septum formation inhibitor [Clostridium ...

211

conserved gene; putative drug target function;

Phase 4: April 2009

1HF2

29.7%

Clostridium perfringens

Cellular processes

Cell division

IDP01847
(show subtarget assignments)

1

soluble

No

GBAA5416

47530729

ftsE

cell division ABC transporter, ATP-bindi...

214

Conserved; Drug target functions

Phase 3: June 2008

3DHW

41.1%

Bacillus anthracis

Cellular processes

Cell division

IDP04093
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1907

218929023

irp5

yersiniabactin siderophore biosynthetic ...

525

drug target; virulence factor; conserved gene; putative drug target function;...

Phase 4: April 2009

1MD9

47.8%

Yersinia pestis

Cellular processes

Cell division

IDP04042
(show subtarget assignments)

1

cloned

No

CPF_0296

110798725

putative cell division ATP-binding prote...

228

conserved gene; putative drug target function;

Phase 4: April 2009

1F3O

40.6%

Clostridium perfringens

Cellular processes

Cell division

IDP01811
(show subtarget assignments)

1

expressed

No

FTT0908

56708009

parB

chromosome partition protein B [Francise...

304

Conserved; Drug target functions

Phase 3: June 2008

1VZ0

23.7%

Francisella tularensis

Cellular processes

Cell division

IDP00473
(show subtarget assignments)

1

cloned

No

YPO0107

16120454

ftsN

cell division protein FtsN

281

Conserved Gene / Pathway

Phase 2: March 2008

1UTA

15.3%

Yersinia pestis

Cellular processes

Cell division

IDP04036
(show subtarget assignments)

1

cloned

No

CPF_1970

110800938

smc

chromosome segregation protein SMC [Clos...

1185

conserved gene; putative drug target function;

Phase 4: April 2009

3AUX

8.2%

Clostridium perfringens

Cellular processes

Cell division

IDP04020
(show subtarget assignments)

1

cloned

No

CPF_2112

110800515

cell division protein FtsQ [Clostridium ...

248

conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cellular processes

Cell division

IDP04010
(show subtarget assignments)

1

cloned

No

CPF_2393

110798628

minD

septum site-determining protein MinD [Cl...

265

conserved gene; putative drug target function;

Phase 4: April 2009

3Q9L

43.4%

Clostridium perfringens

Cellular processes

Cell division

IDP00876
(show subtarget assignments)

1

in_crystallization_trials

No

STM1814

16765155

minC

septum formation inhibitor

235

Conserved Gene / Pathway

Phase 2: March 2008

3GHF

46.4%

Salmonella enterica

Cellular processes

Cell division

IDP00465
(show subtarget assignments)

1

cloned

No

YPO1062

16121362

tilS

tRNA(Ile)-lysidine synthetase

460

Virulence Associated Factor

Phase 2: March 2008

1NI5

52.8%

Yersinia pestis

Cellular processes

Cell division

IDP00865
(show subtarget assignments)

1

expressed

No

STM3570

16766856

ftsE

cell division protein FtsE

222

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

41.9%

Salmonella enterica

Cellular processes

Cell division

IDP02605
(show subtarget assignments)

1

cloned

No

YPO3502

16123648

hflB

ATP-dependent metalloprotease [Yersinia ...

644

Drug target motif; Conserved; CD; Drug target functions

Phase 3: June 2008

2DHR

40.7%

Yersinia pestis

Cellular processes

Cell division

Targets