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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 17 of 60, showing 100 records out of 5973 total, starting on record 1601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP05032
(
show subtarget assignments
)
1
cloned
No
BA_1198
30255151
hypothetical protein BA_1198 [Bacillus a...
47
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05381
(
show subtarget assignments
)
1
cloned
No
BA_0711
30254309
gerLC
spore germination protein GerLC [Bacillu...
388
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3N54
24.7%
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP04027
(
show subtarget assignments
)
1
cloned
No
BAS4637
49187628
leucyl-tRNA synthetase [Bacillus anthrac...
802
Proposed to be essential proteins
Phase 4: April 2009
1H3N
45.9%
Bacillus anthracis
IDP05088
(
show subtarget assignments
)
1
cloned
No
BA_0871
30254621
LPXTG-motif cell wall anchor domain prot...
969
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3KPT
10.8%
Bacillus anthracis
Cell envelope: Other
IDP04217
(
show subtarget assignments
)
1
cloned
No
STM2619_1_203
16765939
hypothetical protein STM2619 [Salmonella...
203
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05504
(
show subtarget assignments
)
1
purified
No
CD0869
126698446
modA
putative molybdenum ABC transporter,subs...
270
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1AMF
31.9%
Clostridium difficile
Transport and binding proteins: Anions
IDP05387
(
show subtarget assignments
)
1
purified
No
BA_2041
30256692
putative oligopeptide ABC transporter, o...
553
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1B05
31.3%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP04619
(
show subtarget assignments
)
1
in_pdb
4DIB
No
BAS4478
49187473
glyceraldehyde-3-phosphate dehydrogenase...
342
Proposed to be essential proteins
Phase 4: April 2009
4DIB
100%
Bacillus anthracis
IDP04625
(
show subtarget assignments
)
1
cloned
No
BAS5050
49188036
glycosyl transferase, group 4 family pro...
357
Proposed to be essential proteins
Phase 4: April 2009
Bacillus anthracis
IDP05380
(
show subtarget assignments
)
1
soluble
No
BA_0633
30254236
gerKC
spore germination protein GerKC [Bacillu...
374
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3N54
22.7%
Bacillus anthracis
Cellular processes: Sporulation and germination
IDP04618
(
show subtarget assignments
)
1
cloned
No
BAS4456
49187451
phenylalanyl-tRNA synthetase subunit alp...
344
Proposed to be essential proteins
Phase 4: April 2009
2RHQ
57.6%
Bacillus anthracis
IDP04637
(
show subtarget assignments
)
1
cloned
No
FTT0371c
56707522
folC
FolC bifunctional protein [Francisella t...
393
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1W78
29.8%
Francisella tularensis
IDP05379
(
show subtarget assignments
)
1
soluble
No
BA_5417
30259888
cccB
cytochrome c-551 [Bacillus anthracis str...
107
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1B7V
29.9%
Bacillus anthracis
Energy metabolism: Electron transport
IDP05378
(
show subtarget assignments
)
1
soluble
No
BA_4133
30258639
hypothetical protein BA_4133 [Bacillus a...
81
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05750
(
show subtarget assignments
)
1
cloned
No
lmo0237
16802283
gltX
hypothetical protein lmo0237 [Listeria m...
491
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2O5R
43.2%
Listeria monocytogenes
Protein synthesis: tRNA aminoacylation
IDP05491
(
show subtarget assignments
)
1
purified
No
BA_3560
30258091
putative glycerophosphoryl diester phosp...
314
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2OOG
45.9%
Bacillus anthracis
Fatty acid and phospholipid metabolism: Degradation
IDP05382
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_0925
30254668
putative lipoprotein [Bacillus anthracis...
325
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2QPQ
23.1%
Bacillus anthracis
Cell envelope: Other
IDP04026
(
show subtarget assignments
)
1
expressed
No
FTT0456c
56707598
hypothetical protein FTT_0456c [Francise...
97
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
1YHD
39.2%
Francisella tularensis
IDP91187
(
show subtarget assignments
)
1
in_pdb
3UZR
4DCA
Yes
AF207840_1
10130002
aph(2')-Ib
aminoglycoside phosphotransferase [Enter...
299
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3HAM
100%
Enterococcus faecium
IDP05719
(
show subtarget assignments
)
1
soluble
No
BA_1903
30256563
peptidase, M23/M37 family [Bacillus anth...
564
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3SLU
15.2%
Bacillus anthracis
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP04621
(
show subtarget assignments
)
1
cloned
No
BAS4494
49187489
acetyl-CoA carboxylase carboxyltransfera...
324
Proposed to be essential proteins
Phase 4: April 2009
2F9I
60.2%
Bacillus anthracis
IDP05026
(
show subtarget assignments
)
1
cloned
No
BA_0025
30253539
putative csfB protein [Bacillus anthraci...
59
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Unknown function: General
IDP04025
(
show subtarget assignments
)
1
expressed
No
YPCD1.36c
16082724
yscX
hypothetical protein YPCD1.36c [Yersinia...
122
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04396
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS4797
49187787
pyridine nucleotide-disulphide oxidoredu...
331
Proposed to be essential proteins
Phase 4: April 2009
3LZW
76.7%
Bacillus anthracis
IDP04620
(
show subtarget assignments
)
1
cloned
No
BAS4482
49187477
DNA polymerase I [Bacillus anthracis str...
891
Proposed to be essential proteins
Phase 4: April 2009
3TAN
45%
Bacillus anthracis
IDP04395
(
show subtarget assignments
)
1
cloned
No
FTT0076
56707255
sucA
2-oxoglutarate dehydrogenase E1 componen...
941
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2JGD
47.8%
Francisella tularensis
IDP05386
(
show subtarget assignments
)
1
soluble
No
BA_2029
30256682
hypothetical protein BA_2029 [Bacillus a...
168
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04024
(
show subtarget assignments
)
1
cloned
No
BAS5319
49188303
DNA-binding response regulator YycF [Bac...
235
Proposed to be essential proteins
Phase 4: April 2009
2OQR
47.7%
Bacillus anthracis
IDP04340
(
show subtarget assignments
)
1
cloned
No
BAS0122
49183156
50S ribosomal protein L5 [Bacillus anthr...
179
Proposed to be essential proteins
Phase 4: April 2009
1IQ4
85.5%
Bacillus anthracis
IDP05384
(
show subtarget assignments
)
1
soluble
No
BA_1466
30255398
conserved domain protein [Bacillus anthr...
172
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP05708
(
show subtarget assignments
)
1
soluble
No
lmo2839
16804876
-
hypothetical protein lmo2839 [Listeria m...
430
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3QUF
24.4%
Listeria monocytogenes
Transport and binding proteins: Unknown substrate
IDP05388
(
show subtarget assignments
)
1
soluble
No
BA_2383
30257018
hypothetical protein BA_2383 [Bacillus a...
191
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05056
(
show subtarget assignments
)
1
soluble
No
CD0257
126697829
motB
chemotaxis protein [Clostridium difficil...
231
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2K1S
20.3%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04728
(
show subtarget assignments
)
1
selected
No
BAS0102
49183136
DNA-directed RNA polymerase subunit beta...
1177
Proposed to be essential proteins
Phase 4: April 2009
1HQM
49.2%
Bacillus anthracis
IDP05059
(
show subtarget assignments
)
1
soluble
No
CD0690
126698269
putative nucleotide phosphodiesterase [C...
655
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3GVE
15.3%
Clostridium difficile
Unknown function: Enzymes of unknown specificity
IDP04224
(
show subtarget assignments
)
8
selected
No
CAC05802
12329071
ipaC
IpaC, secreted by the Mxi-Spa secretion ...
363
Shigella effector protein
Community Requests
Shigella flexneri
IDP04626
(
show subtarget assignments
)
1
cloned
No
BAS5178
49188164
peptide chain release factor 1 [Bacillus...
358
Proposed to be essential proteins
Phase 4: April 2009
1ZBT
59.2%
Bacillus anthracis
IDP04624
(
show subtarget assignments
)
1
in_pdb
3B2B
3UWD
No
BAS4988
49187974
phosphoglycerate kinase [Bacillus anthra...
394
Proposed to be essential proteins
Phase 4: April 2009
3B2B
99.7%
Bacillus anthracis
IDP91022
(
show subtarget assignments
)
8
cloned
No
y2966
22126843
ompC
outer membrane porin protein C [Yersinia...
374
drug resistance /
outer membrane porin
Community Requests
2IXX
67.9%
Yersinia pestis
IDP04222
(
show subtarget assignments
)
8
selected
No
CAC05827
12329096
spa33
Spa33, component of the Mxi-Spa secretio...
293
Shigella effector protein
Community Requests
Shigella flexneri
IDP05601
(
show subtarget assignments
)
1
soluble
No
BA_4147
30258652
conserved hypothetical protein [Bacillus...
344
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP91089
(
show subtarget assignments
)
8
soluble
No
NT06FT0892
0
323
potential drug target /
KDO is an essential component of the lipopolysaccharide (LPS) layer. Cells defec...
Community Requests
2XHZ
31.9%
Francisella tularensis
Energy metabolism: Sugars
IDP05390
(
show subtarget assignments
)
1
soluble
No
BA_2766
30257370
putative lipoprotein [Bacillus anthracis...
165
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP04218
(
show subtarget assignments
)
1
expressed
No
STM2996_1_1123
16766298
recC
exonuclease V subunit gamma [Salmonella ...
1123
Salmonella essential protein
Phase 4: April 2009
1W36
88.4%
Salmonella enterica
IDP05391
(
show subtarget assignments
)
1
cloned
No
BA_2630
30257247
conserved hypothetical protein [Bacillus...
51
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP05389
(
show subtarget assignments
)
1
cloned
No
BA_2660
30257276
hypothetical protein BA_2660 [Bacillus a...
31
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05027
(
show subtarget assignments
)
1
purified
No
BA_0231
30253731
putative oligopeptide ABC transporter, o...
555
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3DRF
27.3%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP04221
(
show subtarget assignments
)
1
expressed
No
STM4262_1_688
16767512
putative ABC-type bacteriocin/lantibioti...
688
Salmonella essential protein
Phase 4: April 2009
3G5U
21.5%
Salmonella enterica
IDP05395
(
show subtarget assignments
)
1
cloned
No
BA_2942
30257534
putative lipoprotein [Bacillus anthracis...
86
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05707
(
show subtarget assignments
)
1
expressed
No
lmo2762
16804799
-
hypothetical protein lmo2762 [Listeria m...
100
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1H9C
44%
Listeria monocytogenes
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
IDP05392
(
show subtarget assignments
)
1
cloned
No
BA_3222
30257786
hypothetical protein BA_3222 [Bacillus a...
56
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04623
(
show subtarget assignments
)
1
expressed
No
BAS4760
49187751
glucose-1-phosphate adenylyltransferase ...
376
Proposed to be essential proteins
Phase 4: April 2009
3BRK
40%
Bacillus anthracis
IDP05393
(
show subtarget assignments
)
1
expressed
No
BA_3225
30257788
hypothetical protein BA_3225 [Bacillus a...
200
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05401
(
show subtarget assignments
)
1
expressed
No
BA_4365
30258863
hypothetical protein BA_4365 [Bacillus a...
83
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04732
(
show subtarget assignments
)
1
cloned
No
BAS5341
49188325
50S ribosomal protein L34 [Bacillus anth...
44
Proposed to be essential proteins
Phase 4: April 2009
1NKW
65.9%
Bacillus anthracis
IDP04223
(
show subtarget assignments
)
8
selected
No
CAC05808
12329077
ipgD
IpgD, secreted by the Mxi-Spa machinery,...
538
Shigella effector protein
Community Requests
Shigella flexneri
IDP04219
(
show subtarget assignments
)
1
cloned
No
STM3148_1_392
16766448
hybB
putative hydrogenase 2 b cytochrome subu...
392
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP05003
(
show subtarget assignments
)
1
cloned
No
BA_3309
30257855
hypothetical protein BA_3309 [Bacillus a...
31
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP04030
(
show subtarget assignments
)
1
cloned
No
YPO2532
115348229
hypothetical protein [Yersinia pestis CO...
70
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP04028
(
show subtarget assignments
)
1
purified
No
BAS0109
49183143
30S ribosomal protein S10 [Bacillus anth...
102
Proposed to be essential proteins
Phase 4: April 2009
1P6G
61.8%
Bacillus anthracis
IDP05397
(
show subtarget assignments
)
1
purified
No
BA_3670
30258191
sspN
small, acid-soluble spore protein N [Bac...
44
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP05398
(
show subtarget assignments
)
1
soluble
No
BA_3750
30258269
putative phosphonate ABC transporter, ph...
312
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3N5L
21.8%
Bacillus anthracis
Transport and binding proteins: Other
IDP05768
(
show subtarget assignments
)
1
cloned
No
SACOL0553
57651385
hypothetical protein SACOL0553 [Staphylo...
431
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
3A2K
28.1%
Staphylococcus aureus
Protein synthesis: tRNA and rRNA base modification
IDP05412
(
show subtarget assignments
)
1
soluble
No
BA_3584
30258112
putative microbial collagenase [Bacillus...
971
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2Y3U
38.9%
Bacillus anthracis
Protein fate: Degradation of proteins, peptides, and glycopeptides
IDP04530
(
show subtarget assignments
)
1
soluble
No
STM2519_1_490
16765839
engA
GTP-binding protein EngA [Salmonella typ...
490
Salmonella essential protein
Phase 4: April 2009
2HJG
36.1%
Salmonella enterica
IDP04038
(
show subtarget assignments
)
1
expressed
No
YPCD1.65
5832485
YPCD1.65
putative transposase [Yersinia pestis CO...
102
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
IDP05406
(
show subtarget assignments
)
1
in_crystallization_trials
No
BA_0669
30254269
rbsB
ribose ABC transporter, ribose-binding p...
308
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2IOY
51.9%
Bacillus anthracis
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
IDP05082
(
show subtarget assignments
)
1
cloned
No
lmo2179
16804218
-
peptidoglycan binding protein [Listeria ...
1152
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KT7
2.3%
Listeria monocytogenes
Regulatory functions: Other
IDP05405
(
show subtarget assignments
)
1
expressed
No
BA_0837
30254426
putative lipoprotein [Bacillus anthracis...
179
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3K0Z
78.2%
Bacillus anthracis
Cell envelope: Other
IDP05113
(
show subtarget assignments
)
1
in_pdb
4EGU
No
CD2447
126700064
histidine triad nucleotide-binding prote...
119
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
4EGU
100%
Clostridium difficile
Unknown function: General
IDP04527
(
show subtarget assignments
)
1
cloned
No
STM1824_1_454
16765165
pabB
para-aminobenzoate synthase component I ...
454
Salmonella essential protein
Phase 4: April 2009
1K0E
76.2%
Salmonella enterica
IDP04064
(
show subtarget assignments
)
1
expressed
No
BAS0127
49183161
30S ribosomal protein S5 [Bacillus anthr...
166
Proposed to be essential proteins
Phase 4: April 2009
1PKP
75.3%
Bacillus anthracis
IDP05408
(
show subtarget assignments
)
1
soluble
No
BA_1977
30256632
putative polysaccharide deacetylase [Bac...
273
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2C1G
31.1%
Bacillus anthracis
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP05654
(
show subtarget assignments
)
1
soluble
No
lmo0105
16802153
-
hypothetical protein lmo0105 [Listeria m...
756
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1ITX
19.4%
Listeria monocytogenes
Energy metabolism: ATP-proton motive force interconversion
IDP04310
(
show subtarget assignments
)
1
cloned
No
BAS0231
49183264
D-alanine--D-alanine ligase, C-terminus ...
91
Proposed to be essential proteins
Phase 4: April 2009
2I80
54.9%
Bacillus anthracis
IDP05411
(
show subtarget assignments
)
1
purified
No
BA_2793
30257397
putative chitin binding protein [Bacillu...
455
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2XWX
21.3%
Bacillus anthracis
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP91186
(
show subtarget assignments
)
1
in_crystallization_trials
No
CAA37605
47078
unnamed protein product [Streptomyces gr...
272
drug resistance /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1ND4
39.8%
Streptomyces griseus
IDP05410
(
show subtarget assignments
)
1
soluble
No
BA_2500
30257128
hypothetical protein BA_2500 [Bacillus a...
156
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05413
(
show subtarget assignments
)
1
cloned
No
BA_3890
30258404
hypothetical protein BA_3890 [Bacillus a...
30
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05031
(
show subtarget assignments
)
1
soluble
No
BA_0908
30254654
oligopeptide ABC transporter, oligopepti...
528
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
1XOC
30.7%
Bacillus anthracis
Transport and binding proteins: Amino acids, peptides and amines
IDP04227
(
show subtarget assignments
)
1
expressed
No
CPF_0198
110799765
sensory box histidine kinase [Clostridiu...
791
conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
11.6%
Clostridium perfringens
Regulatory functions
IDP05052
(
show subtarget assignments
)
1
expressed
No
CD0239
126697810
fliC
flagellin subunit [Clostridium difficile...
290
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3K8W
34.8%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP04307
(
show subtarget assignments
)
1
cloned
No
CPF_1812
110799901
putative lipoprotein [Clostridium perfri...
44
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
IDP04731
(
show subtarget assignments
)
1
crystallized
No
BAS3675
49186674
ribosome recycling factor [Bacillus anth...
185
Proposed to be essential proteins
Phase 4: April 2009
1IS1
50.8%
Bacillus anthracis
IDP05415
(
show subtarget assignments
)
1
soluble
No
BA_5219
30259700
putative ABC transporter, substrate-bind...
268
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
4EF1
49.6%
Bacillus anthracis
Transport and binding proteins: Unknown substrate
IDP04627
(
show subtarget assignments
)
8
cloned
No
BAS5321
49188305
replicative DNA helicase [Bacillus anthr...
453
Proposed to be essential proteins
Community Requests
2VYE
75.3%
Bacillus anthracis
IDP04636
(
show subtarget assignments
)
1
soluble
No
FTT0238
56707395
aroE1
shikimate 5-dehydrogenase [Francisella t...
257
drug target; conserved gene;
Phase 4: April 2009
3O8Q
36.8%
Francisella tularensis
IDP04628
(
show subtarget assignments
)
1
soluble
No
BAS5322
49188306
50S ribosomal protein L9 [Bacillus anthr...
148
Proposed to be essential proteins
Phase 4: April 2009
1DIV
75%
Bacillus anthracis
IDP05418
(
show subtarget assignments
)
1
soluble
No
BA_1561
30255862
conserved hypothetical protein [Bacillus...
129
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Conserved
IDP05417
(
show subtarget assignments
)
1
purified
No
BA_4788
30259274
conserved domain protein [Bacillus anthr...
152
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3SIK
82.9%
Bacillus anthracis
Hypothetical proteins: Domain
IDP05419
(
show subtarget assignments
)
1
soluble
No
BA_5318
30259794
endonuclease/exonuclease/phosphatase fam...
352
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Unknown function: General
IDP05440
(
show subtarget assignments
)
1
soluble
No
BA_3272
30257827
hypothetical protein BA_3272 [Bacillus a...
213
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP05422
(
show subtarget assignments
)
1
soluble
No
BA_1872
30256537
putative lipoprotein [Bacillus anthracis...
126
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05421
(
show subtarget assignments
)
1
soluble
No
BAS1418
49184435
-
hypothetical protein BAS1418 [Bacillus a...
237
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Cell envelope: Other
IDP05653
(
show subtarget assignments
)
1
cloned
No
lmo0146
16802194
-
hypothetical protein lmo0146 [Listeria m...
68
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Listeria monocytogenes
IDP04309
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0050
49183085
peptidyl-tRNA hydrolase [Bacillus anthra...
186
Proposed to be essential proteins
Phase 4: April 2009
3KJZ
40.9%
Bacillus anthracis
IDP05424
(
show subtarget assignments
)
1
cloned
No
lmo0438
16802482
-
hypothetical protein lmo0438 [Listeria m...
192
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2XL4
89.1%
Listeria monocytogenes
IDP05051
(
show subtarget assignments
)
1
cloned
No
CD0127
126697699
mreB1
rod shape-determining protein Mbl [Clost...
339
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
1JCE
52.2%
Clostridium difficile
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP91789
(
show subtarget assignments
)
8
purified
No
TETS_LISMO
6094462
RecName: Full=Tetracycline resistance pr...
641
drug resistance /
Tetracycline resistance
Community Requests
1DAR
27.6%
Listeria monocytogenes
IDP91788
(
show subtarget assignments
)
8
in_crystallization_trials
No
ACM47287
222159814
vanD
D-Ala:D-Lac ligase VanD [Enterococcus fa...
343
drug resistance /
D-Ala:D-Lac ligase
Community Requests
1E4E
67.1%
Enterococcus faecium
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