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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 17 of 60, showing 100 records out of 5973 total, starting on record 1601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP90257
(
show subtarget assignments
)
8
purified
No
SAR1996
49484145
lig
DNA ligase [Staphylococcus aureus subsp....
667
(From requester) potential drug target for S. aureus
Community Requests
3JSL
46.3%
Staphylococcus aureus
IDP91391
(
show subtarget assignments
)
8
cloned
No
VV1_1292
27364692
mutL
DNA mismatch repair protein [Vibrio vuln...
664
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
1B62
36.4%
Vibrio vulnificus
IDP92139
(
show subtarget assignments
)
8
selected
No
TGME49_058030
237831459
DNA polymerase delta catalytic subunit, ...
1268
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3IAY
28.2%
Toxoplasma gondii
IDP92037
(
show subtarget assignments
)
8
selected
No
TGME49_033820
237837865
DNA polymerase delta small subunit, puta...
492
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3E0J
27%
Toxoplasma gondii
IDP04620
(
show subtarget assignments
)
1
cloned
No
BAS4482
49187477
DNA polymerase I [Bacillus anthracis str...
891
Proposed to be essential proteins
Phase 4: April 2009
3TAN
45%
Bacillus anthracis
IDP91261
(
show subtarget assignments
)
8
soluble
No
NT05BA0041
49176992
DNA polymerase III, delta prime subunit ...
327
potential drug target /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1A5T
20.2%
Bacillus anthracis
DNA metabolism: DNA replication, recombination, and repair
IDP90624
(
show subtarget assignments
)
8
cloned
No
Cj0718
15792067
dnaE
DNA polymerase III subunit alpha [Campyl...
1200
Predicted Essential
Community Requests
2HPI
37%
Campylobacter jejuni
IDP90928
(
show subtarget assignments
)
8
soluble
No
VC2245
15642243
dnaE
DNA polymerase III subunit alpha [Vibrio...
1164
Predicted Essential
Community Requests
2HQA
62.5%
Vibrio cholerae
IDP90818
(
show subtarget assignments
)
8
expressed
No
YPO1059
16121359
dnaE
DNA polymerase III subunit alpha [Yersin...
1171
Predicted Essential
Community Requests
2HQA
70%
Yersinia pestis
IDP04571
(
show subtarget assignments
)
1
cloned
No
BAS0002
49183041
DNA polymerase III subunit beta [Bacillu...
379
Proposed to be essential proteins
Phase 4: April 2009
2AWA
42%
Bacillus anthracis
IDP90614
(
show subtarget assignments
)
8
crystallized
No
VC0013
15640045
DNA polymerase III subunit beta [Vibrio ...
366
Predicted Essential
Community Requests
1MMI
63.9%
Vibrio cholerae
IDP04212
(
show subtarget assignments
)
1
cloned
No
STM0646_1_343
16764023
holA
DNA polymerase III subunit delta [Salmon...
343
Salmonella essential protein
Phase 4: April 2009
1JQJ
89.8%
Salmonella enterica
IDP90644
(
show subtarget assignments
)
8
in_crystallization_trials
No
STM1201
16764556
holB
DNA polymerase III subunit delta' [Salmo...
334
Predicted Essential
Community Requests
1A5T
79%
Salmonella enterica
IDP90848
(
show subtarget assignments
)
8
cloned
No
VC0953
15640969
holA
DNA polymerase III subunit delta [Vibrio...
342
Predicted Essential
Community Requests
1JQJ
49.1%
Vibrio cholerae
IDP90607
(
show subtarget assignments
)
8
purified
No
VC2015
15642017
DNA polymerase III subunit delta' [Vibri...
324
Predicted Essential
Community Requests
1A5T
33%
Vibrio cholerae
IDP90919
(
show subtarget assignments
)
8
expressed
No
YPO2608
16122821
holA
DNA polymerase III subunit delta [Yersin...
344
Predicted Essential
Community Requests
1JQJ
71.5%
Yersinia pestis
IDP90924
(
show subtarget assignments
)
8
purified
No
YPO1606
16121874
holB
DNA polymerase III subunit delta' [Yersi...
340
Predicted Essential
Community Requests
1A5T
51.5%
Yersinia pestis
IDP90616
(
show subtarget assignments
)
8
selected
No
VC1054
15641067
DNA polymerase III subunits gamma and ta...
692
Predicted Essential
Community Requests
1JR3
34.5%
Vibrio cholerae
IDP90891
(
show subtarget assignments
)
8
cloned
No
YPO3122
16123287
dnaX
DNA polymerase III subunits gamma and ta...
658
Predicted Essential
Community Requests
1JR3
46.7%
Yersinia pestis
IDP92012
(
show subtarget assignments
)
8
selected
No
TGME49_037830
237845437
DNA polymerase I, putative [Toxoplasma g...
938
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
2BDP
17.4%
Toxoplasma gondii
IDP92070
(
show subtarget assignments
)
8
selected
No
TGME49_084010
237839683
DNA polymerase I, putative [Toxoplasma g...
461
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1BGX
16.9%
Toxoplasma gondii
IDP90712
(
show subtarget assignments
)
8
cloned
No
Cj1638
15792943
dnaG
DNA primase [Campylobacter jejuni subsp....
605
Predicted Essential
Community Requests
2AU3
18.3%
Campylobacter jejuni
IDP92078
(
show subtarget assignments
)
8
selected
No
TGME49_097840
237843813
DNA primase, large subunit, putative [To...
584
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3L9Q
12.7%
Toxoplasma gondii
IDP05233
(
show subtarget assignments
)
1
cloned
No
lmo1455
16803495
dnaG
DNA primase [Listeria monocytogenes EGD-...
626
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2AU3
21.7%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP90681
(
show subtarget assignments
)
8
purified
No
STM3210
16766510
dnaG
DNA primase [Salmonella typhimurium LT2]...
581
Predicted Essential
Community Requests
1DD9
46.1%
Salmonella enterica
IDP92116
(
show subtarget assignments
)
8
selected
No
TGME49_060680
237831887
DNA primase small subunit, putative [Tox...
509
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1G71
9.2%
Toxoplasma gondii
IDP90503
(
show subtarget assignments
)
8
purified
No
NP_230169
15642769
DNA primase [Vibrio cholerae O1 biovar e...
587
Predicted Essential
Community Requests
1DD9
30.8%
Vibrio cholerae
IDP90594
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO0644
16120969
dnaG
DNA primase [Yersinia pestis CO92]
582
Predicted Essential
Community Requests
1DD9
45.7%
Yersinia pestis
IDP91342
(
show subtarget assignments
)
8
expressed
No
VV2_0079
27366538
DNA repair exonuclease [Vibrio vulnificu...
377
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3QG5
25.8%
Vibrio vulnificus
IDP01807
(
show subtarget assignments
)
1
cloned
No
FTT0873c
56707977
radA
DNA repair protein RadA [Francisella tul...
456
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3K1J
15.1%
Francisella tularensis
DNA metabolism
DNA replication, recombination, and repair
IDP90943
(
show subtarget assignments
)
8
purified
No
BAS0032
49183067
DNA replication intiation control protei...
121
This is an essential protein that connects DNA replication to cell growth by bin...
Community Requests
Bacillus anthracis
IDP90996
(
show subtarget assignments
)
8
in_pdb
4DYU
No
y1677
22125572
dps
DNA starvation/stationary phase protecti...
167
other biological interest /
global stress response protein
Community Requests
4DYU
100%
Yersinia pestis
IDP04275
(
show subtarget assignments
)
1
cloned
No
BAS3684
49186683
DNA topoisomerase I [Bacillus anthracis ...
692
Proposed to be essential proteins
Phase 4: April 2009
2GAI
38.2%
Bacillus anthracis
IDP90582
(
show subtarget assignments
)
8
soluble
No
Cj1686c
15792989
topA
DNA topoisomerase I [Campylobacter jejun...
700
Predicted Essential
Community Requests
2GAI
38.6%
Campylobacter jejuni
IDP04081
(
show subtarget assignments
)
1
purified
No
BAS0361
49183389
DNA topoisomerase III [Bacillus anthraci...
729
Proposed to be essential proteins
Phase 4: April 2009
1D6M
27.7%
Bacillus anthracis
IDP05706
(
show subtarget assignments
)
1
purified
No
lmo2756
16804793
topB
DNA topoisomerase III [Listeria monocyto...
717
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1D6M
28.6%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP92142
(
show subtarget assignments
)
8
selected
No
TGME49_112230
237830295
DNA topoisomerase II, putative [Toxoplas...
1687
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
3QX3
22.5%
Toxoplasma gondii
IDP05323
(
show subtarget assignments
)
1
cloned
No
lmo1275
16803315
topA
DNA topoisomerase I [Listeria monocytoge...
692
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2GAI
38.4%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP90524
(
show subtarget assignments
)
8
purified
No
VC1730
15641734
DNA topoisomerase I [Vibrio cholerae O1 ...
876
Predicted Essential
Community Requests
1CY0
48.3%
Vibrio cholerae
IDP02479
(
show subtarget assignments
)
1
cloned
No
lmo1287
16803327
parC
DNA topoisomerase IV subunit A [Listeria...
819
Predicted virulence-Resistance to antibiotics and toxic compounds; Drug Target H...
Phase 3: June 2008
2INR
41.8%
Listeria monocytogenes
DNA metabolism
DNA replication, recombination, and repair
IDP90865
(
show subtarget assignments
)
8
purified
No
VC2430
15642427
DNA topoisomerase IV subunit A [Vibrio c...
761
Predicted Essential
Community Requests
1ZVU
66.9%
Vibrio cholerae
IDP90866
(
show subtarget assignments
)
8
cloned
No
YPO0671
16120996
parC
DNA topoisomerase IV subunit A [Yersinia...
757
Predicted Essential
Community Requests
1ZVU
78.2%
Yersinia pestis
IDP05229
(
show subtarget assignments
)
1
cloned
No
lmo1286
16803326
parE
DNA topoisomerase IV subunit B [Listeria...
655
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
1EI1
29.8%
Listeria monocytogenes
DNA metabolism: DNA replication, recombination, and repair
IDP90817
(
show subtarget assignments
)
8
cloned
No
VC2431
15642428
DNA topoisomerase IV subunit B [Vibrio c...
626
Predicted Essential
Community Requests
1S16
49.8%
Vibrio cholerae
IDP90796
(
show subtarget assignments
)
8
purified
No
YPO2218
16122447
topA
DNA topoisomerase I [Yersinia pestis CO9...
871
Predicted Essential
Community Requests
1CY0
57.4%
Yersinia pestis
IDP91892
(
show subtarget assignments
)
8
selected
No
SpneCM_010100009040
298255720
DNA translocase ftsk [Streptococcus pneu...
741
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2IUT
33.5%
Streptococcus pneumoniae
IDP91435
(
show subtarget assignments
)
8
cloned
No
VV1_0485
27363949
DNA uptake lipoprotein [Vibrio vulnificu...
241
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3TGO
48.5%
Vibrio vulnificus
IDP01318
(
show subtarget assignments
)
1
in_pdb
3IQ1
No
VC0139
15640170
DPS family protein
156
Conserved Gene / Pathway
Phase 2: March 2008
3IQ1
100%
Vibrio cholerae
Cellular processes
Adaptations to atypical conditions
IDP00079
(
show subtarget assignments
)
1
in_pdb
3DSA
3E7N
No
NT01ST4845
16422456
rbsD
D-ribose high-affinity transport system ...
139
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3DSA
100%
Salmonella enterica
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP01481
(
show subtarget assignments
)
1
expressed
No
VCA0130
15600901
D-ribose transporter subunit RbsB
294
Conserved Gene / Pathway
Phase 2: March 2008
1DBP
65.3%
Vibrio cholerae
Transport and binding proteins
Carbohydrates, organic alcohols, and acids
IDP02542
(
show subtarget assignments
)
1
in_pdb
3INP
No
FTT0789
56707900
rpe
D-ribulose-phosphate 3-epimerase [Franci...
222
Drug Target
Phase 3: June 2008
3INP
100%
Francisella tularensis
Energy metabolism
Pentose phosphate pathway
IDP00618
(
show subtarget assignments
)
1
purified
No
SACOL2348
57285082
drug transporter, putative
215
Conserved Gene / Pathway
Phase 2: March 2008
Staphylococcus aureus
Cellular processes
Toxin production and resistance
IDP01110
(
show subtarget assignments
)
1
in_pdb
3RYK
Yes
BA_1229
30255178
rfbC
dTDP-4-dehydrorhamnose 3,5-epimerase
181
Conserved Gene / Pathway
Phase 2: March 2008
3RYK
100%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP01195
(
show subtarget assignments
)
1
in_pdb
3SC6
No
BA_1231
30255180
rfbD
dTDP-4-dehydrorhamnose reductase
284
Drug Target Function
Phase 2: March 2008
3SC6
100%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90837
(
show subtarget assignments
)
8
selected
No
S2226
30063491
rfbD
dTDP-4-dehydrorhamnose reductase [Shigel...
299
Predicted Essential
Community Requests
1KBZ
85.6%
Shigella flexneri
IDP90841
(
show subtarget assignments
)
8
soluble
No
S2223
30063489
rfbC
dTDP-6-deoxy-L-mannose-dehydrogenase [Sh...
181
Predicted Essential
Community Requests
1DZR
70.2%
Shigella flexneri
IDP90851
(
show subtarget assignments
)
8
purified
No
YPO3862
16123997
rffG
dTDP-D-glucose-4,6-dehydratase [Yersinia...
355
Predicted Essential
Community Requests
1BXK
82%
Yersinia pestis
IDP01194
(
show subtarget assignments
)
1
in_pdb
4EGB
No
BA_1230
30255179
rfbB
dTDP-glucose 4,6-dehydratase
322
Conserved Gene / Pathway
Phase 2: March 2008
4EGB
100%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP91459
(
show subtarget assignments
)
8
soluble
No
VV1_0096
27363580
dTDP-glucose pyrophosphorylase [Vibrio v...
115
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91729
(
show subtarget assignments
)
8
selected
No
NP_660186
21735544
MAP2K7
dual specificity mitogen-activated prote...
419
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2DYL
72.3%
Homo sapiens
IDP90295
(
show subtarget assignments
)
8
cloned
No
TGME49_005290
211965425
dual-specificity phosphatase laforin, pu...
523
Human Lafora disease is one of five major progressive myoclonus epilepsies that ...
Community Requests
Toxoplasma gondii
IDP91337
(
show subtarget assignments
)
8
cloned
No
VV2_0138
27366594
EAL domain-containing protein [Vibrio vu...
588
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2R6O
15.3%
Vibrio vulnificus
IDP02142
(
show subtarget assignments
)
1
cloned
No
CBU_0754
29541354
efflux transporter, RND family, MFP subu...
348
Conserved; Drug target functions
Phase 3: June 2008
1VF7
24.7%
Coxiella burnetii
Transport and binding proteins
Other
IDP01754
(
show subtarget assignments
)
1
expressed
No
CBU_0803
29541397
efflux transporter, RND family, MFP subu...
351
Conserved; Drug target functions
Phase 3: June 2008
1T5E
27.9%
Coxiella burnetii
Transport and binding proteins
Other
IDP01734
(
show subtarget assignments
)
1
cloned
No
CBU_1094
29541668
efflux transporter, RND family, MFP subu...
380
Conserved; Drug target functions
Phase 3: June 2008
3FPP
23.9%
Coxiella burnetii
Transport and binding proteins
Other
IDP91691
(
show subtarget assignments
)
8
selected
No
NP_001034438
86788132
EFEMP1
EGF-containing fibulin-like extracellula...
493
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1N7D
19.7%
Homo sapiens
IDP02412
(
show subtarget assignments
)
1
soluble
No
GBAA4760
47530059
etfB
electron transfer flavoprotein, beta sub...
257
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
1EFP
38.2%
Bacillus anthracis
Energy metabolism
Electron transport
IDP05021
(
show subtarget assignments
)
1
soluble
No
CD1139
126698733
rnfG
electron transport complex protein [Clos...
189
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Transport and binding proteins: Amino acids, peptides and amines
IDP00452
(
show subtarget assignments
)
1
purified
No
YPO2245
16122473
electron transport complex protein RnfB ...
188
Conserved Gene / Pathway
Phase 2: March 2008
1GT8
14.4%
Yersinia pestis
Unknown function
General
IDP00512
(
show subtarget assignments
)
1
cloned
No
YPO2244
16122472
electron transport complex protein RnfC ...
620
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91352
(
show subtarget assignments
)
8
cloned
No
VV1_3095
27366363
electron transport complex protein RnfC ...
919
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP91351
(
show subtarget assignments
)
8
expressed
No
VV1_3096
27366364
rnfD
electron transport complex protein RnfD ...
355
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00742
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1276
57286013
tsf
elongation factor Ts
293
Drug Target Function
Phase 2: March 2008
3AGP
44%
Staphylococcus aureus
Protein synthesis
Translation factors
IDP02709
(
show subtarget assignments
)
1
purified
No
GBAA3964
47529254
tsf
elongation factor Ts [Bacillus anthracis...
295
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
1EFU
47.1%
Bacillus anthracis
Protein synthesis
Translation factors
IDP01057
(
show subtarget assignments
)
0
work_stopped
No
STM3445
16766734
tuf
elongation factor Tu
394
Conserved Gene / Pathway
Phase 2: March 2008
1D8T
99.5%
Salmonella enterica
Protein synthesis
Translation factors
IDP01035
(
show subtarget assignments
)
0
work_stopped
No
STM4146
16767400
tuf
elongation factor Tu
394
Conserved Gene / Pathway
Phase 2: March 2008
1D8T
99.5%
Salmonella enterica
Protein synthesis
Translation factors
IDP04581
(
show subtarget assignments
)
1
in_crystallization_trials
No
BAS0108
49183142
elongation factor Tu [Bacillus anthracis...
395
Proposed to be essential proteins
Phase 4: April 2009
3U2Q
75.4%
Bacillus anthracis
IDP91904
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000777
298254134
endo-beta-N-acetylglucosaminidase, parti...
573
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2WW5
20.9%
Streptococcus pneumoniae
IDP05638
(
show subtarget assignments
)
1
cloned
No
CD2546
126700163
endoglucanase (cellulase) [Clostridium d...
340
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3AMC
39.7%
Clostridium difficile
Energy metabolism: Biosynthesis and degradation of polysaccharides
IDP05419
(
show subtarget assignments
)
1
soluble
No
BA_5318
30259794
endonuclease/exonuclease/phosphatase fam...
352
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Unknown function: General
IDP91943
(
show subtarget assignments
)
8
selected
No
SpneCM_010100009678
298255846
endonuclease/exonuclease/phosphatase fam...
333
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP00676
(
show subtarget assignments
)
1
expressed
No
SACOL1492
57284593
nth
endonuclease III
219
Drug Target Function
Phase 2: March 2008
1ORN
62.1%
Staphylococcus aureus
DNA metabolism
DNA replication, recombination, and repair
IDP02389
(
show subtarget assignments
)
1
cloned
No
lmo0232
16802278
clpC
endopeptidase Clp ATP-binding chain C [L...
820
Known virulence-Invasion; PMID:11083831; Presence of Protease Motifs
Phase 3: June 2008
3PXI
72.8%
Listeria monocytogenes
Energy metabolism
ATP-proton motive force interconversion
IDP01851
(
show subtarget assignments
)
1
cloned
No
GBAA5427
47778402
endopeptidase lytE, putative [Bacillus a...
436
Drug target motif; Involved in sporulation; Drug target functions
Phase 3: June 2008
3H41
9.9%
Bacillus anthracis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP01009
(
show subtarget assignments
)
1
cloned
No
STM2535
16765855
sseB
enhanced serine sensitivity protein
261
Conserved Gene / Pathway
Phase 2: March 2008
Salmonella enterica
Protein fate
Protein and peptide secretion and trafficking
IDP00050
(
show subtarget assignments
)
1
cloned
No
BA_3443
30257983
enhancin family protein
742
Virulence
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Pathogenesis
IDP00180
(
show subtarget assignments
)
1
expressed
No
YPO0339
16120675
-
enhancing factor (viral)
856
Virulence
Phase 1: October 2007
Yersinia pestis
Mobile and extrachromosomal element functions
Transposon functions
IDP90293
(
show subtarget assignments
)
8
in_pdb
3OTR
No
TGME49_068860
211963243
enolase 1 [Toxoplasma gondii ME49]
444
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
100%
Toxoplasma gondii
IDP02814
(
show subtarget assignments
)
1
cloned
No
FTT0709
56707828
eno
enolase (2-phosphoglycerate dehydratase)...
456
Conserved; Drug target functions
Phase 3: June 2008
1IYX
60.5%
Francisella tularensis
Energy metabolism
Glycolysis/gluconeogenesis
IDP90296
(
show subtarget assignments
)
8
purified
No
TGME49_068850
211963242
enolase 2 [Toxoplasma gondii ME49]
475
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
68.8%
Toxoplasma gondii
IDP00787
(
show subtarget assignments
)
0
work_stopped
No
SACOL1016
57284388
fabI
enoyl-(acyl carrier protein) reductase
256
Drug Target Function
Phase 2: March 2008
3GNS
100%
Staphylococcus aureus
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01256
(
show subtarget assignments
)
0
work_stopped
No
BA_1232
30255181
fabI
enoyl-(acyl-carrier-protein) reductase
256
Drug Target Function
Phase 2: March 2008
2QIO
100%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP90705
(
show subtarget assignments
)
8
soluble
No
Cj1400c
15792718
fabI
enoyl-(acyl carrier protein) reductase [...
274
Predicted Essential
Community Requests
2PD3
67.2%
Campylobacter jejuni
IDP05676
(
show subtarget assignments
)
1
in_crystallization_trials
No
lmo0970
16803010
-
enoyl-(acyl carrier protein) reductase [...
262
potential drug target /
Known drug target or ortholog of known drug target
Phase 5: 2010
2QIO
61.8%
Listeria monocytogenes
Fatty acid and phospholipid metabolism: Biosynthesis
IDP02329
(
show subtarget assignments
)
1
in_pdb
3KQF
Yes
GBAA2551
47527840
enoyl-CoA hydratase [Bacillus anthracis ...
262
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3KQF
100%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Degradation
IDP04689
(
show subtarget assignments
)
1
in_pdb
3PEA
Yes
GBAA4761
47530060
enoyl-CoA hydratase [Bacillus anthracis ...
258
conserved gene; putative drug target function;
Phase 4: April 2009
3PEA
100%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Degradation
IDP00118
(
show subtarget assignments
)
1
in_pdb
3MGA
No
NT01ST0713
16763963
fes
enterobactin/ferric enterobactin esteras...
404
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3MGA
100%
Salmonella enterica
Transport and binding proteins
Cations and iron carrying compounds
IDP00153
(
show subtarget assignments
)
1
expressed
No
VC0475
15640502
irgA
enterobactin receptor
652
Virulence
Phase 1: October 2007
2HDF
37.1%
Vibrio cholerae
Transport and binding proteins
Cations and iron carrying compounds
IDP01760
(
show subtarget assignments
)
1
expressed
No
Cj1354
15792677
ceuD
enterochelin uptake ATP-binding protein ...
251
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
1F3O
32.7%
Campylobacter jejuni
Fatty acid and phospholipid metabolism
Biosynthesis
IDP00037
(
show subtarget assignments
)
0
work_stopped
No
BA_1887
30256548
enterotoxin
386
Virulence
Phase 1: October 2007
Bacillus anthracis
Cellular processes
Toxin production and resistance
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