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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
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IDP#
NCBI GI
LOCUS TAG
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Page 17 of 60, showing 100 records out of 5973 total, starting on record 1601
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP05036
(
show subtarget assignments
)
1
cloned
No
BA_1663
30255960
hypothetical protein BA_1663 [Bacillus a...
450
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
IDP01080
(
show subtarget assignments
)
0
work_stopped
No
STM4220
16767470
lysC
aspartate kinase III
449
Conserved Gene / Pathway
Phase 2: March 2008
2J0W
93.1%
Salmonella enterica
Amino acid biosynthesis
Aspartate family
IDP91358
(
show subtarget assignments
)
8
soluble
No
VV1_2848
27366130
Signal transduction histidine kinase [Vi...
449
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3JZ3
12.5%
Vibrio vulnificus
IDP90007
(
show subtarget assignments
)
8
cloned
No
Z4378
12517596
qseC
quorum sensing Escherichia coli regulato...
449
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3JZ3
47%
Escherichia coli
IDP01705
(
show subtarget assignments
)
1
in_pdb
3N5M
No
BAS1519
49184534
aminotransferase [Bacillus anthracis str...
449
CONSERVED GENE/PATHWAY
Phase 3: June 2008
3N5M
99.6%
Bacillus anthracis
N/A
N/A
IDP91733
(
show subtarget assignments
)
8
selected
No
P88946_HHV8
0
449
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2DLL
6.9%
Human herpesvirus
IDP04132
(
show subtarget assignments
)
1
cloned
No
YPO2997
218930046
putative two-component system sensor kin...
449
putative drug target function;
Phase 4: April 2009
3JZ3
15.4%
Yersinia pestis
Regulatory functions
Other
IDP00668
(
show subtarget assignments
)
1
crystallized
No
SACOL1196
57284481
murD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...
449
Conserved Gene / Pathway
Phase 2: March 2008
3LK7
46.3%
Staphylococcus aureus
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01220
(
show subtarget assignments
)
1
purified
No
BA_3983
30258492
ffH
signal recognition particle protein
449
Conserved Gene / Pathway
Phase 2: March 2008
2XXA
51.9%
Bacillus anthracis
Protein fate
Protein and peptide secretion and trafficking
IDP04486
(
show subtarget assignments
)
1
cloned
No
YPO3597
115349218
conserved hypothetical protein [Yersinia...
448
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP92022
(
show subtarget assignments
)
8
selected
No
TGME49_009160
237840757
glycylpeptide N-tetradecanoyltransferase...
448
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1RXT
48.9%
Toxoplasma gondii
IDP02746
(
show subtarget assignments
)
0
work_stopped
No
GBAA0157
47525415
glmM
phosphoglucosamine mutase [Bacillus anth...
448
Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3PDK
100%
Bacillus anthracis
Cell envelope
N/A
IDP90998
(
show subtarget assignments
)
8
cloned
No
y1724
22125618
hypothetical protein y1724 [Yersinia pes...
448
other biological interest /
Found by experiment to have a DNA binding function - an unknown DNA binding prot...
Community Requests
Yersinia pestis
IDP04467
(
show subtarget assignments
)
1
soluble
No
YPO2174
218929273
putative nucleotide sugar dehydrogenase ...
448
virulence factor; putative drug target function;
Phase 4: April 2009
2Y0E
57.9%
Yersinia pestis
Unclassified
Role category not yet assigned
IDP91914
(
show subtarget assignments
)
8
selected
No
SpneCMD_010100003195
298229663
choline binding protein D [Streptococcus...
448
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
2V04
14.3%
Streptococcus pneumoniae
IDP90314
(
show subtarget assignments
)
8
soluble
No
CT_733
3329191
hypothetical protein [Chlamydia trachoma...
448
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP02411
(
show subtarget assignments
)
1
expressed
No
YPO3640
16123782
hypothetical protein YPO3640 [Yersinia p...
448
Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...
Phase 3: June 2008
Yersinia pestis
Cell envelope
Other
IDP91414
(
show subtarget assignments
)
8
soluble
No
VV1_0699
27364155
peptidase PmbA [Vibrio vulnificus CMCP6]...
447
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
3TV9
62%
Vibrio vulnificus
IDP90725
(
show subtarget assignments
)
8
soluble
No
VC0295
15640323
acetyl-CoA carboxylase biotin carboxylas...
447
Predicted Essential
Community Requests
1BNC
85.5%
Vibrio cholerae
IDP01995
(
show subtarget assignments
)
1
soluble
No
CBU_2012
29542567
hslU
heat shock protein HslVU, ATPase subunit...
447
Conserved; Drug target functions
Phase 3: June 2008
1DO0
67.3%
Coxiella burnetii
Protein fate
Protein folding and stabilization
IDP04523
(
show subtarget assignments
)
1
cloned
No
STM0884_1_447
16764245
ulaA
ascorbate-specific PTS system enzyme IIC...
447
Salmonella essential protein
Phase 4: April 2009
Salmonella enterica
IDP91504
(
show subtarget assignments
)
8
cloned
No
VP1670
28898444
putative translocation protein in type I...
446
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio parahaemolyticus
IDP04363
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3500
115349125
mrsA
probable phosphoglucomutase/phosphomanno...
446
drug target; putative drug target function;
Phase 4: April 2009
3PDK
46.4%
Yersinia pestis
Energy metabolism
Sugars
IDP01743
(
show subtarget assignments
)
1
purified
No
CBU_1350
29541915
glmM
phosphoglucosamine mutase [Coxiella burn...
446
Conserved; Drug target functions
Phase 3: June 2008
3PDK
44.1%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP05138
(
show subtarget assignments
)
1
cloned
No
CD2874
126700490
putative drug/sodium antiporter [Clostri...
446
virulence/pathogenesis /
Targets associated with virulence and/or pathogenesis
Phase 5: 2010
Clostridium difficile
Transport and binding proteins: Other
IDP02731
(
show subtarget assignments
)
1
expressed
No
CBU_0124
29540744
murF
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,...
446
Conserved; Drug target functions
Phase 3: June 2008
1GG4
43.9%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP01332
(
show subtarget assignments
)
1
purified
No
VC0639
15640659
phosphoglucomutase/phosphomannomutase fa...
446
Drug Target Function
Phase 2: March 2008
3PDK
46.6%
Vibrio cholerae
Energy metabolism
Sugars
IDP00004
(
show subtarget assignments
)
1
soluble
No
BA_0001
38257418
Chromosomal replication initiator protei...
446
Drug Target Homolog
Phase 1: October 2007
2Z4R
37.2%
Bacillus anthracis
DNA metabolism
DNA replication, recombination, and repair
IDP02188
(
show subtarget assignments
)
1
expressed
No
YPO0267
16120605
type III secretion system ATPase [Yersin...
445
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
2DPY
43.6%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP00899
(
show subtarget assignments
)
1
soluble
No
STM3294
16766590
glmM
phosphoglucosamine mutase
445
Essential Gene
Phase 2: March 2008
3PDK
46.7%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02328
(
show subtarget assignments
)
1
expressed
No
GBAA2548
47527837
acetyl-CoA carboxylase biotin carboxylas...
445
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3N6R
51.9%
Bacillus anthracis
Fatty acid and phospholipid metabolism
Biosynthesis
IDP01764
(
show subtarget assignments
)
1
cloned
No
Cj1434c
15792752
putative sugar transferase [Campylobacte...
445
Known Predicted virulence-capsule biosynthesis anmd transport; Possible Vaccine ...
Phase 3: June 2008
3L7I
16.2%
Campylobacter jejuni
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90700
(
show subtarget assignments
)
8
soluble
No
Cj0196c
15791583
purF
amidophosphoribosyltransferase [Campylob...
445
Predicted Essential
Community Requests
1AO0
46.3%
Campylobacter jejuni
IDP01346
(
show subtarget assignments
)
1
cloned
No
VC1621
15641628
agglutination protein
445
Conserved Gene / Pathway
Phase 2: March 2008
2VDD
24.9%
Vibrio cholerae
Cellular processes
Pathogenesis
IDP91212
(
show subtarget assignments
)
8
cloned
No
BLIJ_1793
189439586
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
445
potential drug target /
Shikimate pathway enzyme
Community Requests
2BJB
44.9%
Bifidobacterium longum
IDP04252
(
show subtarget assignments
)
1
cloned
No
CPF_1780
110799805
putative lipoprotein [Clostridium perfri...
445
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cell envelope
Other
IDP91650
(
show subtarget assignments
)
8
cloned
No
NP_216898
15609519
polyketide synthetase MBTC (polyketide s...
444
virulence/pathogenesis /
All of the mbt genes are involved in biosynthesis of the mycobactins, which are ...
Community Requests
2QO3
47.1%
Mycobacterium tuberculosis
IDP02286
(
show subtarget assignments
)
1
cloned
No
FTT1029
56708118
dacD
D-alanyl-D-alanine carboxypeptidase (pen...
444
Conserved; Drug target functions; Drug target motif
Phase 3: June 2008
3IT9
31.1%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02777
(
show subtarget assignments
)
1
soluble
No
GBAA4698
47529997
hemA
glutamyl-tRNA reductase [Bacillus anthra...
444
Conserved; Drug target functions
Phase 3: June 2008
1GPJ
27.3%
Bacillus anthracis
Biosynthesis of cofactors, prosthetic groups, and carriers
Heme, porphyrin, and cobalamin
IDP02718
(
show subtarget assignments
)
1
cloned
No
GBAA3833
47529118
glnA
glutamine synthetase, type I [Bacillus a...
444
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
3QAJ
86.7%
Bacillus anthracis
Amino acid biosynthesis
Glutamate family
IDP04125
(
show subtarget assignments
)
1
cloned
No
YPO2847
115348521
yegM
putitive HlyD family secretion protein [...
444
conserved gene; putative drug target function;
Phase 4: April 2009
3FPP
21.2%
Yersinia pestis
Protein fate
Protein and peptide secretion and trafficking
IDP90293
(
show subtarget assignments
)
8
in_pdb
3OTR
No
TGME49_068860
211963243
enolase 1 [Toxoplasma gondii ME49]
444
Complimentarily to TgENO1, enolase 2 (TgENO2) is expressed specifically in tachy...
Community Requests
3OTR
100%
Toxoplasma gondii
IDP01454
(
show subtarget assignments
)
1
purified
No
VC2403
161581989
murD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...
444
Conserved Gene / Pathway
Phase 2: March 2008
1E0D
51.8%
Vibrio cholerae
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP00341
(
show subtarget assignments
)
1
cloned
No
FTT1305c
56708363
murA
UDP-N-acetylglucosamine 1-carboxyvinyltr...
444
Drug Target Function
Phase 2: March 2008
3SG1
32.7%
Francisella tularensis
IDP05705
(
show subtarget assignments
)
1
cloned
No
lmo2642
16804680
-
hypothetical protein lmo2642 [Listeria m...
443
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2XMO
99.8%
Listeria monocytogenes
IDP04491
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO3765
218930769
pepQ
proline dipeptidase [Yersinia pestis CO9...
443
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3RVA
54.8%
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02164
(
show subtarget assignments
)
1
in_pdb
3I3W
Yes
FTT0079
56707258
mrsA
phosphoglucosamine mutase [Francisella t...
443
Conserved; Drug target functions
Phase 3: June 2008
3I3W
100%
Francisella tularensis
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP90722
(
show subtarget assignments
)
8
in_pdb
3OUZ
3OUU
No
Cj1290c
15792613
accC
biotin carboxylase [Campylobacter jejuni...
443
Predicted Essential
Community Requests
3OUU
100%
Campylobacter jejuni
IDP91948
(
show subtarget assignments
)
8
selected
No
SpneCM_010100000392
298254057
histidine kinase PnpS [Streptococcus pne...
443
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3A0R
19.4%
Streptococcus pneumoniae
IDP02160
(
show subtarget assignments
)
1
soluble
No
CBU_1245
29541815
GTP-binding protein [Coxiella burnetii R...
443
Conserved; Drug target functions
Phase 3: June 2008
2HJG
38.4%
Coxiella burnetii
Unknown function
General
IDP00736
(
show subtarget assignments
)
1
in_pdb
3FF1
No
SACOL0966
57285840
pgi
glucose-6-phosphate isomerase
443
Drug Target Function
Phase 2: March 2008
3FF1
100%
Staphylococcus aureus
Energy metabolism
Glycolysis/gluconeogenesis
IDP91711
(
show subtarget assignments
)
8
selected
No
NP_006550
5730027
KHDRBS1
KH domain-containing, RNA-binding, signa...
443
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
2BL5
14.7%
Homo sapiens
IDP01185
(
show subtarget assignments
)
1
cloned
No
BA_0280
30253775
glycosyl transferase, group 1 family pro...
443
Drug Target Function
Phase 2: March 2008
2JJM
13.5%
Bacillus anthracis
Cell envelope
Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
IDP90119
(
show subtarget assignments
)
8
soluble
No
MPXV_ZAI1979_005_029
68449103
ankyrin-like protein [Monkeypox virus]
442
similar to VACV-COP-M1L, MPXV-ZAI96-O1L
Community Requests
1N11
16.3%
Monkeypox virus
IDP90387
(
show subtarget assignments
)
8
expressed
No
CT_372
3328796
hypothetical protein [Chlamydia trachoma...
442
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Chlamydia trachomatis
IDP91953
(
show subtarget assignments
)
8
cloned
No
SpneCM_010100002215
298254414
extracellular solute-binding lipoprotein...
442
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
3QUF
20.6%
Streptococcus pneumoniae
IDP01797
(
show subtarget assignments
)
1
cloned
No
CBU_1008
29541590
bioA
adenosylmethionine-8-amino-7-oxononanoat...
442
Conserved; Drug target functions
Phase 3: June 2008
3DOD
35.4%
Coxiella burnetii
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
IDP02592
(
show subtarget assignments
)
1
expressed
No
GBAA1308
47526573
glycolate oxidase, iron-sulfur subunit, ...
442
Conserved; Drug target functions
Phase 3: June 2008
Bacillus anthracis
Energy metabolism
Other
IDP02141
(
show subtarget assignments
)
1
purified
No
CBU_0737
29541337
tig
trigger factor [Coxiella burnetii RSA 49...
442
Conserved; Drug target functions
Phase 3: June 2008
1W26
41%
Coxiella burnetii
Protein fate
Protein and peptide secretion and trafficking
IDP91513
(
show subtarget assignments
)
8
expressed
No
VV2_1516
27367863
HlyD family secretion protein [Vibrio vu...
442
essential/virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
Vibrio vulnificus
IDP00649
(
show subtarget assignments
)
1
in_pdb
3R2U
No
SACOL0046
57286601
metallo-beta-lactamase family protein
442
Drug Target Function
Phase 2: March 2008
3R2U
100%
Staphylococcus aureus
Unknown function
Enzymes of unknown specificity
IDP04152
(
show subtarget assignments
)
1
cloned
No
YPO3919
218930919
HlyD family secretion protein [Yersinia ...
442
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
Yersinia pestis
Protein fate
Degradation of proteins, peptides, and glycopeptides
IDP02024
(
show subtarget assignments
)
1
expressed
No
CBU_0131
29540751
murD
UDP-N-acetylmuramoylalanine--D-glutamate...
442
Conserved; Drug target functions
Phase 3: June 2008
1E0D
43%
Coxiella burnetii
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP91006
(
show subtarget assignments
)
8
soluble
No
y1937
22125829
cysteine desulfurase activator complex s...
441
potential drug target /
part of iron-sulfur cluster assembly system active under stress conditions
Community Requests
1VH4
56%
Yersinia pestis
IDP00228
(
show subtarget assignments
)
1
cloned
No
YPO3388
16123537
-
putative chloride channel protein
441
Virulence
Phase 1: October 2007
1KPL
76.6%
Yersinia pestis
Transcription
Transcription factors
IDP02649
(
show subtarget assignments
)
1
purified
No
STM1795
16765136
putative glutamic dehyrogenase-like prot...
441
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
3AOE
58.5%
Salmonella enterica
Amino acid biosynthesis
Glutamate family
IDP92102
(
show subtarget assignments
)
8
selected
No
TGME49_069110
237832613
ornithine aminotransferase, putative [To...
441
potential drug target /
TDR Toxoplasma Targets (Phase III)
Community Requests
1GBN
47.2%
Toxoplasma gondii
IDP01894
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM0564
16763941
pyridine nucleotide-disulfide oxidoreduc...
441
Conserved; Drug target functions
Phase 3: June 2008
2EQ6
32.7%
Salmonella enterica
Unknown function
Enzymes of unknown specificity
IDP90308
(
show subtarget assignments
)
8
cloned
No
CT_700
3329154
hypothetical protein [Chlamydia trachoma...
441
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
1NA0
6.3%
Chlamydia trachomatis
IDP90696
(
show subtarget assignments
)
8
in_crystallization_trials
No
YPO1022
16121323
argA
N-acetylglutamate synthase [Yersinia pes...
441
Predicted Essential
Community Requests
2R8V
38.8%
Yersinia pestis
IDP91567
(
show subtarget assignments
)
8
cloned
No
BAB35235
13361277
ECs1812
hypothetical protein [Escherichia coli O...
441
virulence/pathogenesis /
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
Escherichia coli
IDP00564
(
show subtarget assignments
)
1
selected
No
YPO1403
16121683
mukF
condesin subunit F
440
Conserved Gene / Pathway
Phase 2: March 2008
3EUH
84.8%
Yersinia pestis
Cellular processes
Toxin production and resistance
IDP91751
(
show subtarget assignments
)
8
selected
No
STRP_STREQ
0
440
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1BML
81.1%
Streptococcus dysgalactiae
IDP90747
(
show subtarget assignments
)
8
soluble
No
Cj0001
15791400
dnaA
chromosomal replication initiation prote...
440
Predicted Essential
Community Requests
2Z4R
34.3%
Campylobacter jejuni
IDP90666
(
show subtarget assignments
)
8
purified
No
VC2242
15642240
mesJ protein [Vibrio cholerae O1 biovar ...
440
Predicted Essential
Community Requests
1NI5
44.1%
Vibrio cholerae
IDP90272
(
show subtarget assignments
)
8
cloned
No
TGME49_111670
211962063
hypothetical protein TGME49_111670 [Toxo...
440
Unpublished data from signature-tagged mutagenesis (STM) has identified this sur...
Community Requests
Toxoplasma gondii
IDP04007
(
show subtarget assignments
)
1
expressed
No
VC1319
15641331
sensor histidine kinase [Vibrio cholerae...
440
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
2C2A
15.2%
Vibrio cholerae
Regulatory functions
Other
IDP02023
(
show subtarget assignments
)
1
soluble
No
STM3661
16766946
xylA
xylose isomerase [Salmonella typhimurium...
440
Conserved; Drug target functions
Phase 3: June 2008
1A0D
51.6%
Salmonella enterica
Energy metabolism
Sugars
IDP04200
(
show subtarget assignments
)
1
expressed
No
CPF_0244
110798897
putative lipoprotein [Clostridium perfri...
440
drug target; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cell envelope
Other
IDP90883
(
show subtarget assignments
)
8
soluble
No
VC0062
15640094
thiE
thiamine-phosphate pyrophosphorylase [Vi...
440
Predicted Essential
Community Requests
3O63
16.1%
Vibrio cholerae
IDP05176
(
show subtarget assignments
)
1
soluble
No
BA_2967
30257557
conserved domain protein [Bacillus anthr...
440
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Bacillus anthracis
Hypothetical proteins: Domain
IDP04251
(
show subtarget assignments
)
1
cloned
No
CPF_1751
110801372
virS
sensor histidine kinase VirS [Clostridiu...
440
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Toxin production and resistance
IDP91506
(
show subtarget assignments
)
8
expressed
No
VP1668
28898442
type III secretion system ATPase [Vibrio...
440
virulence/pathogenesis /
Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...
Community Requests
2DPY
44.1%
Vibrio parahaemolyticus
IDP91927
(
show subtarget assignments
)
8
selected
No
SpneCM_010100001844
298254341
hypothetical protein SpneCM_01844 [Strep...
439
Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...
Community Requests
Streptococcus pneumoniae
IDP91683
(
show subtarget assignments
)
8
selected
No
MYC_HUMAN
0
439
virulence/pathogenesis /
Selected from a set of pathogenic interactions taken from IRefIndex
Community Requests
1NKP
18.9%
Homo sapiens
IDP02829
(
show subtarget assignments
)
1
cloned
No
GBAA4382
47529677
bfmbB
branched-chain alpha-keto acid dehydroge...
439
Conserved; Essential; Involved in sporulation; Drug target functions
Phase 3: June 2008
3DUF
38.4%
Bacillus anthracis
Energy metabolism
Amino acids and amines
IDP00450
(
show subtarget assignments
)
1
cloned
No
YPCD1.40
16082728
yscN
type III secretion system ATPase
439
Virulence Associated Factor
Phase 2: March 2008
2DPY
42.8%
Yersinia pestis
Energy metabolism
ATP-proton motive force interconversion
IDP90401
(
show subtarget assignments
)
8
cloned
No
CT_579
3329021
hypothetical protein [Chlamydia trachoma...
439
These targets are similar to actual drug targets and will be used mostly for coc...
Community Requests
3V47
14.8%
Chlamydia trachomatis
IDP05555
(
show subtarget assignments
)
1
cloned
No
lmo1413
16803453
-
peptidoglycan binding protein [Listeria ...
439
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
2KVZ
6.2%
Listeria monocytogenes
Cell envelope: Other
IDP05728
(
show subtarget assignments
)
1
cloned
No
CD0251
126697822
fliI
flagellum-specific ATP synthase [Clostri...
439
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
2DPY
45.6%
Clostridium difficile
Cellular processes: Chemotaxis and motility
IDP90127
(
show subtarget assignments
)
8
expressed
No
MPXV_ZAI1979_005_045
68449119
ser/thr kinase [Monkeypox virus]
439
similar to VACV-COP-F10L, MPXV-ZAI96-C16L
Community Requests
Monkeypox virus
IDP05348
(
show subtarget assignments
)
1
expressed
No
CD2408
126700023
putative multidrug efflux pump, outer me...
439
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
Clostridium difficile
Cell envelope: Other
IDP05674
(
show subtarget assignments
)
1
soluble
No
lmo0859
16802900
-
hypothetical protein lmo0859 [Listeria m...
439
associated with virulence and/or pathogenesis; vaccine candidate
Phase 5: 2010
3QUF
23.7%
Listeria monocytogenes
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
IDP01842
(
show subtarget assignments
)
1
in_pdb
3SLH
4EGR
3ROI
Yes
CBU_0526
29541129
aroA
3-phosphoshikimate 1-carboxyvinyltransfe...
438
Conserved; Drug target functions
Phase 3: June 2008
3ROI
100%
Coxiella burnetii
Amino acid biosynthesis
Aromatic amino acid family
IDP00905
(
show subtarget assignments
)
0
work_stopped
No
STM0126
16763516
murD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...
438
Essential Gene
Phase 2: March 2008
1E0D
92.2%
Salmonella enterica
Cell envelope
Biosynthesis and degradation of murein sacculus and peptidoglycan
IDP02054
(
show subtarget assignments
)
1
purified
No
FTT0623
56707748
tig
trigger factor [Francisella tularensis s...
438
Conserved; Drug target functions
Phase 3: June 2008
1W26
40.4%
Francisella tularensis
Protein fate
Protein folding and stabilization
IDP04257
(
show subtarget assignments
)
1
cloned
No
CPF_2008
110798819
engA
GTP-binding protein EngA [Clostridium pe...
438
conserved gene; putative drug target function;
Phase 4: April 2009
2HJG
54.3%
Clostridium perfringens
Cellular processes
Cell division
IDP90759
(
show subtarget assignments
)
8
expressed
No
YPO0553
16120881
murD
UDP-N-acetylmuramoyl-L-alanyl-D-glutamat...
438
Predicted Essential
Community Requests
1E0D
80.6%
Yersinia pestis
IDP04481
(
show subtarget assignments
)
1
cloned
No
YPO3204
115348844
nmpB
phosphate regulon sensor protein PhoR [Y...
438
conserved gene; putative drug target function;
Phase 4: April 2009
3A0R
19.9%
Yersinia pestis
Regulatory functions
Other
IDP05518
(
show subtarget assignments
)
1
cloned
No
CD1702
126699308
thiC
thiamine biosynthesis protein ThiC [Clos...
438
essential/virulence/pathogenesis /
Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...
Phase 5: 2010
3EPM
43.1%
Clostridium difficile
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
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