Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP00117 (show subtarget assignments)	1	purified	No	NT01ST0298	16763632	yaeB	putative regulatory protein	235	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	1XQB	47.7%	Salmonella enterica	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91031 (show subtarget assignments)	8	cloned	No	y4125	22127993		solute-binding periplasmic protein precu...	284	other biological interest / highly abundant periplasmic protein with unknown function	Community Requests	1XT8	31%	Yersinia pestis

IDP91990 (show subtarget assignments)	8	selected	No	SpneCM_010100004332	298254829		ABC transporter substrate-binding protei...	80	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1XT8	41.2%	Streptococcus pneumoniae

IDP91967 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100008960	298255704		amino acid ABC transporter, periplasmic ...	268	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1XT8	28.7%	Streptococcus pneumoniae

IDP05490 (show subtarget assignments)	1	soluble	No	BA_5139	30259623	sodC	superoxide dismutase, Cu-Zn [Bacillus an...	179	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XTM	35.2%	Bacillus anthracis	Cellular processes: Detoxification

IDP01703 (show subtarget assignments)	1	in_crystallization_trials	No	Cj1317	15792640	neuB3	N-acetylneuraminic acid synthetase [Camp...	343	Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...	Phase 3: June 2008	1XUU	35.1%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02035 (show subtarget assignments)	1	cloned	No	Cj1141	15792466	neuB1	N-acetylneuraminic acid synthetase [Camp...	343	Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...	Phase 3: June 2008	1XUU	59%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01840 (show subtarget assignments)	1	soluble	No	STM2861	16766167	sitA	putative periplasmic binding protein [Sa...	305	Conserved; Drug target functions	Phase 3: June 2008	1XVL	53.4%	Salmonella enterica	Cell envelope	Other

IDP91001 (show subtarget assignments)	8	soluble	No	y1897	22125790	yfeA	periplasmic-binding protein [Yersinia pe...	323	virulence/pathogenesis / periplasmic iron-binding protein	Community Requests	1XVL	52.9%	Yersinia pestis

IDP00429 (show subtarget assignments)	1	purified	No	YPO2958	16123140	sfuA	iron(III)-binding periplasmic protein	339	Virulence Associated Factor	Phase 2: March 2008	1XVX	79.9%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP92075 (show subtarget assignments)	8	selected	No	TGME49_095690	237844421		ubiquinone/menaquinone biosynthesis meth...	392	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1XXL	8.2%	Toxoplasma gondii

IDP05583 (show subtarget assignments)	1	soluble	No	BA_2249	30256893		SCO1/SenC family lipoprotein [Bacillus a...	195	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1XZO	45.6%	Bacillus anthracis	Unknown function: General

IDP04649 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1283	56708343	trmE	tRNA modification GTPase TrmE [Francisel...	450	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1XZP	36.1%	Francisella tularensis	Protein synthesis	tRNA and rRNA base modification

IDP04120 (show subtarget assignments)	1	soluble	No	BAS1475	49184492		xanthine phosphoribosyltransferase [Baci...	197	Proposed to be essential proteins	Phase 4: April 2009	1Y0B	65%	Bacillus anthracis

IDP00084 (show subtarget assignments)	1	expressed	No	NT01ST1435	16419673	yceI	putative secreted protein	191	Essential	Phase 1: October 2007	1Y0G	91.1%	Salmonella enterica	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04073 (show subtarget assignments)	1	crystallized	No	YPO0502	115346311		conserved hypothetical protein [Yersinia...	172	virulence factor; conserved gene;	Phase 4: April 2009	1Y12	38.4%	Yersinia pestis	Hypothetical proteins	Conserved

IDP92114 (show subtarget assignments)	8	selected	No	TGME49_011330	237843941		methionine aminopeptidase, putative [Tox...	329	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1Y1N	36.8%	Toxoplasma gondii

IDP00840 (show subtarget assignments)	1	purified	No	SACOL1894	57284813		HIT family protein	140	Drug Target Function	Phase 2: March 2008	1Y23	52.1%	Staphylococcus aureus	Unknown function	General

IDP02690 (show subtarget assignments)	1	cloned	No	FTT0954c	56708048		hypothetical protein FTT0954c [Francisel...	106	Drug Target	Phase 3: June 2008	1Y2I	36.8%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP04416 (show subtarget assignments)	1	in_crystallization_trials	No	BAS4049	49187047		ribonuclease Z [Bacillus anthracis str. ...	307	Proposed to be essential proteins	Phase 4: April 2009	1Y44	61.2%	Bacillus anthracis

IDP01491 (show subtarget assignments)	1	soluble	No	VCA0603	15601361		ABC transporter, periplasmic substrate-b...	339	Conserved Gene / Pathway	Phase 2: March 2008	1Y4T	18.3%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP91956 (show subtarget assignments)	8	in_crystallization_trials	No	SpneCM_010100005733	298255095		ABC transporter, substrate-binding prote...	353	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1Y4T	19.8%	Streptococcus pneumoniae

IDP01227 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4268	30258770	ptsH-1	phosphocarrier protein HPr	87	Conserved Gene / Pathway	Phase 2: March 2008	1Y4Y	72.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00628 (show subtarget assignments)	1	cloned	No	SACOL0369	57285482		prophage L54a, Clp protease, putative	257	Drug Target Function	Phase 2: March 2008	1Y7O	22.2%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP91989 (show subtarget assignments)	8	purified	No	SpneCM_010100010148	298255940		serine protease [Streptococcus pneumonia...	393	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	1Y8T	32.1%	Streptococcus pneumoniae

IDP00460 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0914	16121219	serA	D-3-phosphoglycerate dehydrogenase	413	Virulence Associated Factor	Phase 2: March 2008	1YBA	83.8%	Yersinia pestis	Amino acid biosynthesis	Serine family

IDP02113 (show subtarget assignments)	1	in_crystallization_trials	No	STM3901	16767177	ilvG	acetolactate synthase 2 catalytic subuni...	548	Conserved; Drug target functions	Phase 3: June 2008	1YBH	46.7%	Salmonella enterica	Amino acid biosynthesis	Pyruvate family

IDP02296 (show subtarget assignments)	1	crystallized	No	GBAA0020	47525275		hypothetical protein GBAA0020 [Bacillus ...	109	Conserved; Involved in sporulation;	Phase 3: June 2008	1YBX	55.8%	Bacillus anthracis	Hypothetical proteins	Conserved

IDP91514 (show subtarget assignments)	8	expressed	No	VV2_1517	27367864		agglutination protein [Vibrio vulnificus...	436	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YC9	16.5%	Vibrio vulnificus

IDP02653 (show subtarget assignments)	1	in_crystallization_trials	No	STM2840	16766146		anaerobic nitric oxide reductase flavoru...	479	Conserved; Drug target functions	Phase 3: June 2008	1YCF	33.8%	Salmonella enterica	Energy metabolism	Electron transport

IDP90568 (show subtarget assignments)	8	soluble	No	Cj0536	15791897	oorA	2-oxoglutarate-acceptor oxidoreductase s...	374	Predicted Essential	Community Requests	1YD7	43%	Campylobacter jejuni

IDP01788 (show subtarget assignments)	1	crystallized	No	YPO3827	16123962	glpQ	glycerophosphodiester phosphodiesterase ...	371	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1YDY	71.7%	Yersinia pestis	Central intermediary metabolism	Other

IDP00806 (show subtarget assignments)	1	cloned	No	SACOL1861	57284782	hsdS	type I restriction-modification enzyme, ...	399	Drug Target Function	Phase 2: March 2008	1YF2	27.8%	Staphylococcus aureus	DNA metabolism	Restriction/modification

IDP04026 (show subtarget assignments)	1	expressed	No	FTT0456c	56707598		hypothetical protein FTT_0456c [Francise...	97	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YHD	39.2%	Francisella tularensis

IDP00957 (show subtarget assignments)	0	work_stopped	No	STM1202	16764557	ycfH	predicted metallodependent hydrolase	265	Conserved Gene / Pathway	Phase 2: March 2008	1YIX	92.8%	Salmonella enterica	Unknown function	Enzymes of unknown specificity

IDP91493 (show subtarget assignments)	8	cloned	No	VP1690	28898464		putative type III secretion lipoprotein ...	248	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YJ7	23.8%	Vibrio parahaemolyticus

IDP92023 (show subtarget assignments)	8	selected	No	TGME49_010260	237845081		glycerol-3-phosphate dehydrogenase, puta...	515	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1YJ8	33.2%	Toxoplasma gondii

IDP02541 (show subtarget assignments)	1	expressed	No	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP04112 (show subtarget assignments)	1	cloned	No	YPO2626	115348318	nagA	putative N-acetylglucosamine-6-phosphate...	381	drug target; putative drug target function;	Phase 4: April 2009	1YMY	75.1%	Yersinia pestis	Central intermediary metabolism	Amino sugars

IDP05238 (show subtarget assignments)	1	cloned	No	lmo1799	16803839	-	peptidoglycan binding protein [Listeria ...	903	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YO8	10%	Listeria monocytogenes	Cell envelope: Other

IDP05536 (show subtarget assignments)	1	cloned	No	CD3145	126700762		putative serine-aspartate-rich surface a...	1190	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YO8	7.6%	Clostridium difficile	Unknown function: General

IDP05585 (show subtarget assignments)	1	soluble	No	Z0801	12513558	ybeK	putative tRNA synthetase [Escherichia co...	311	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1YOE	99.4%	Escherichia coli	Protein synthesis: tRNA aminoacylation

IDP90126 (show subtarget assignments)	8	expressed	No	MPXV_ZAI1979_005_044	68449118		unknown [Monkeypox virus]	212	thiol substrate, similar to VACV-COP-F9L, MPXV-ZAI96-C15L	Community Requests	1YPY	21.7%	Monkeypox virus

IDP02259 (show subtarget assignments)	1	cloned	No	GBAA2164	47527458		ABC transporter ATP-binding protein [Bac...	631	Conserved; Drug target functions	Phase 3: June 2008	1YQT	21.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01695 (show subtarget assignments)	1	expressed	No	GBAA0228	47525485		ABC transporter ATP-binding protein [Bac...	626	Conserved; Drug target functions	Phase 3: June 2008	1YQT	20.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP01667 (show subtarget assignments)	1	expressed	No	FTT1782c	56708774	yjjK	putative ABC transporter ATP-binding pro...	559	Conserved; Drug target functions	Phase 3: June 2008	1YQT	27.3%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01301 (show subtarget assignments)	1	expressed	No	VC0170	15640200		peptide ABC transporter, ATP-binding pro...	571	Conserved Gene / Pathway	Phase 2: March 2008	1YQT	22.4%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP00065 (show subtarget assignments)	1	expressed	No	BA_5409	30259882		macrolide efflux pump, putative	544	Virulence	Phase 1: October 2007	1YQT	24.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP05496 (show subtarget assignments)	1	soluble	No	BA_4047	30258554		cell division protein FtsQ [Bacillus ant...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YR1	15.5%	Bacillus anthracis	Cellular processes: Cell division

IDP90565 (show subtarget assignments)	8	soluble	No	VC0162	15640192		ketol-acid reductoisomerase [Vibrio chol...	494	Predicted Essential	Community Requests	1YRL	75.3%	Vibrio cholerae

IDP04613 (show subtarget assignments)	1	cloned	No	BAS3890	49186888		M20/M25/M40 family peptidase [Bacillus a...	376	Proposed to be essential proteins	Phase 4: April 2009	1YSJ	35.6%	Bacillus anthracis

IDP00695 (show subtarget assignments)	1	purified	No	SACOL2322	57285057		peptidase, M20/M25/M40 family	373	Drug Target Function	Phase 2: March 2008	1YSJ	41.3%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP04647 (show subtarget assignments)	1	purified	No	FTT1127	56604696		Rhodanese-like family protein [Francisel...	252	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YT8	18.3%	Francisella tularensis

IDP91716 (show subtarget assignments)	8	selected	No	NP_009330	6274552	STAT1	signal transducer and activator of trans...	750	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1YVL	91.1%	Homo sapiens

IDP91706 (show subtarget assignments)	8	selected	No	NP_005410	4885615	STAT2	signal transducer and activator of trans...	851	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	1YVL	36%	Homo sapiens

IDP01351 (show subtarget assignments)	1	cloned	No	VCA0387	15601150		toxin resistance protein	169	Conserved Gene / Pathway	Phase 2: March 2008	1YVO	31.4%	Vibrio cholerae	Cellular processes	Toxin production and resistance

IDP02447 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0561	16802604	hisE	phosphoribosyl-ATP pyrophosphatase [List...	103	Predicted Essential-Modeling; DNA binding Motifs	Phase 3: June 2008	1YVW	54.4%	Listeria monocytogenes	Amino acid biosynthesis	Histidine family

IDP04094 (show subtarget assignments)	1	expressed	No	YPO1966	218929080	astE	succinylglutamate desuccinylase [Yersini...	330	conserved gene; putative drug target function;	Phase 4: April 2009	1YW6	47.9%	Yersinia pestis	Unclassified	Role category not yet assigned

IDP05691 (show subtarget assignments)	1	cloned	No	lmo1800	16803840	-	hypothetical protein lmo1800 [Listeria m...	298	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YWF	25.8%	Listeria monocytogenes	Energy metabolism: Sugars

IDP02472 (show subtarget assignments)	1	in_crystallization_trials	No	YPO3785	16123919		hypothetical protein YPO3785 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1YWF	26.2%	Yersinia pestis	Energy metabolism	Sugars

IDP05291 (show subtarget assignments)	1	in_crystallization_trials	No	CD1211	126698807		putative acetyltransferase [Clostridium ...	163	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	1YX0	23.9%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP91382 (show subtarget assignments)	8	purified	No	VV1_1470	27364854		histone acetyltransferase HPA2 [Vibrio v...	164	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YX0	18.9%	Vibrio vulnificus

IDP04614 (show subtarget assignments)	1	purified	No	BAS4131	49187128		glycine cleavage system aminomethyltrans...	366	Proposed to be essential proteins	Phase 4: April 2009	1YX2	66.1%	Bacillus anthracis

IDP02808 (show subtarget assignments)	1	cloned	No	STM1084	16764443	yccK	sulfurtransferase TusE [Salmonella typhi...	109	Conserved; Drug target functions	Phase 3: June 2008	1YX3	47.7%	Salmonella enterica	Unknown function	General

IDP91365 (show subtarget assignments)	8	soluble	No	VV1_2710	27366000		dissimilatory sulfite reductase, gamma s...	109	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1YX3	48.6%	Vibrio vulnificus

IDP04616 (show subtarget assignments)	1	in_crystallization_trials	No	BAS4313	49187308		S-adenosylmethionine:tRNA ribosyltransfe...	350	Proposed to be essential proteins	Phase 4: April 2009	1YY3	71.4%	Bacillus anthracis

IDP01516 (show subtarget assignments)	1	crystallized	No	VC0576	15640598	sspA	stringent starvation protein A	211	Conserved Gene / Pathway	Phase 2: March 2008	1YY7	73.9%	Vibrio cholerae	Cellular processes	Adaptations to atypical conditions

IDP00354 (show subtarget assignments)	1	cloned	No	lmo2471	16804509		hypothetical protein lmo2471	338	Drug Target Function	Phase 2: March 2008	1Z41	62.4%	Listeria monocytogenes	Fatty acid and phospholipid metabolism	Degradation

IDP00701 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0149	57285352	cap5N	capsular polysaccharide biosynthesis pro...	295	Conserved Gene / Pathway	Phase 2: March 2008	1Z45	22.4%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01066 (show subtarget assignments)	1	expressed	No	STM3819	16767104	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP02381 (show subtarget assignments)	1	expressed	No	GBAA2279	47527580	proV-1	glycine betaine/L-proline ABC transporte...	315	Conserved; Drug target functions	Phase 3: June 2008	1Z47	36.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP00972 (show subtarget assignments)	1	expressed	No	STM1743	16765087	oppD	oligopeptide transporter ATP-binding com...	335	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	25.7%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00863 (show subtarget assignments)	1	expressed	No	STM2254	16765582	ccmA	heme exporter protein	205	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	32.7%	Salmonella enterica	Protein fate	Protein and peptide secretion and trafficking

IDP01671 (show subtarget assignments)	1	cloned	No	YPO3012	16123191	cysA	sulfate/thiosulfate transporter subunit ...	363	Conserved; CD; Drug target functions	Phase 3: June 2008	1Z47	39.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01669 (show subtarget assignments)	1	cloned	No	YPO3048	16123225		ABC transporter ATP-binding protein [Yer...	356	CD; Involved in virulence; Drug target functions	Phase 3: June 2008	1Z47	36.8%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP01654 (show subtarget assignments)	1	expressed	No	STM1259	16764611		putative ABC-type transport system ATPas...	196	Conserved; Drug target functions	Phase 3: June 2008	1Z47	31.6%	Salmonella enterica	Unclassified	Role category not yet assigned

IDP01390 (show subtarget assignments)	1	purified	No	VC0617	15640637		peptide ABC transporter, ATP-binding pro...	327	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	24.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP01149 (show subtarget assignments)	1	purified	No	BA_1195	30254908		oligopeptide ABC transporter, ATP-bindin...	311	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	30.2%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP90292 (show subtarget assignments)	8	cloned	No	TGGT1_004130	221483205		histone acetyltransferase GCN5, putative...	1169	The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...	Community Requests	1Z4R	8.5%	Toxoplasma gondii

IDP01170 (show subtarget assignments)	1	cloned	No	BA_0165	30253674		prolyl oligopeptidase family protein, pu...	654	Drug Target Function	Phase 2: March 2008	1Z68	11.6%	Bacillus anthracis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP92090 (show subtarget assignments)	8	selected	No	TGME49_121570	237844801		(3R)-hydroxymyristoyl ACP dehydrase, put...	231	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1Z6B	35.9%	Toxoplasma gondii

IDP91002 (show subtarget assignments)	8	selected	No	y1919	22125812		bifunctional UDP-glucuronic acid decarbo...	667	virulence/pathogenesis / -	Community Requests	1Z7E	70.2%	Yersinia pestis

IDP02488 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1425	47526697	hisG	ATP phosphoribosyltransferase catalytic ...	211	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1Z7M	49.8%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP02668 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1526	47526800	gpsA	NAD(P)H-dependent glycerol-3-phosphate d...	340	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	1Z82	42.9%	Bacillus anthracis	Energy metabolism	Other

IDP90690 (show subtarget assignments)	8	purified	No	Cj1196c	15792520	gpsA	NAD(P)H-dependent glycerol-3-phosphate d...	298	Predicted Essential	Community Requests	1Z82	35.8%	Campylobacter jejuni

IDP05296 (show subtarget assignments)	1	purified	No	CD2138	126699755	pyrH	uridylate kinase [Clostridium difficile ...	234	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1Z9D	59.1%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01674 (show subtarget assignments)	1	cloned	No	lmo2543	16804581	prfA	peptide chain release factor 1 [Listeria...	358	Predicted virulence-Regulation	Phase 3: June 2008	1ZBT	63.7%	Listeria monocytogenes	Protein synthesis	Translation factors

IDP00750 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2110	57286326	prfA	peptide chain release factor 1	358	Drug Target Function	Phase 2: March 2008	1ZBT	58.4%	Staphylococcus aureus	Protein synthesis	Translation factors

IDP04626 (show subtarget assignments)	1	cloned	No	BAS5178	49188164		peptide chain release factor 1 [Bacillus...	358	Proposed to be essential proteins	Phase 4: April 2009	1ZBT	59.2%	Bacillus anthracis

IDP02477 (show subtarget assignments)	1	cloned	No	YPO2035	16122274		hypothetical protein YPO2035 [Yersinia p...	276	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	1ZCC	23.6%	Yersinia pestis	Central intermediary metabolism	Other

IDP02094 (show subtarget assignments)	1	cloned	No	STM3598	16766884		putative L-asparaginase [Salmonella typh...	347	Conserved; Drug target functions	Phase 3: June 2008	1ZCF	68.9%	Salmonella enterica	Energy metabolism	Amino acids and amines

IDP04126 (show subtarget assignments)	1	cloned	No	YPO2871	115348542	guaB	inosine-5'-monophosphate dehydrogenase [...	487	conserved gene; putative drug target function;	Phase 4: April 2009	1ZFJ	56.1%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP90125 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_038	68449112		kelch-like protein [Monkeypox virus]	485	similar to VACV-COP-F3L, MPXV-ZAI96-C9L	Community Requests	1ZGK	13.6%	Monkeypox virus

IDP04119 (show subtarget assignments)	1	crystallized	No	BAS0131	49183165		adenylate kinase [Bacillus anthracis str...	216	Proposed to be essential proteins	Phase 4: April 2009	1ZIN	74.1%	Bacillus anthracis

IDP05663 (show subtarget assignments)	1	selected	No	lmo0333	16802378	-	hypothetical protein lmo0333 [Listeria m...	1778	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1ZIW	9.1%	Listeria monocytogenes	Cellular processes: Pathogenesis

IDP91877 (show subtarget assignments)	8	selected	No	CAB89086	7649401	fox-4	beta-lactamase class C [Escherichia coli...	382	potential drug target / Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...	Community Requests	1ZKJ	71.7%	Escherichia coli

IDP02417 (show subtarget assignments)	1	cloned	No	FTT0812	56707923	gcvH1	glycine cleavage system protein H [Franc...	126	Conserved; Drug target functions	Phase 3: June 2008	1ZKO	40.5%	Francisella tularensis	Energy metabolism	Amino acids and amines

IDP91821 (show subtarget assignments)	8	soluble	No	b2926	1789294	pgk	phosphoglycerate kinase [Escherichia col...	387	potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...	Community Requests	1ZMR	100%	Escherichia coli

IDP02688 (show subtarget assignments)	0	work_stopped	No	YPO0921	16121226	pgk	phosphoglycerate kinase [Yersinia pestis...	387	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	1ZMR	88.6%	Yersinia pestis	Energy metabolism	Glycolysis/gluconeogenesis

IDP91433 (show subtarget assignments)	8	in_crystallization_trials	No	VV1_0488	27363952		NTPase [Vibrio vulnificus CMCP6]	183	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1ZNO	68.3%	Vibrio vulnificus

IDP00117
(show subtarget assignments)

1

purified

No

NT01ST0298

16763632

yaeB

putative regulatory protein

235

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

1XQB

47.7%

Salmonella enterica

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP91031
(show subtarget assignments)

8

cloned

No

y4125

22127993

solute-binding periplasmic protein precu...

284

other biological interest / highly abundant periplasmic protein with unknown function

Community Requests

1XT8

31%

Yersinia pestis

IDP91990
(show subtarget assignments)

8

selected

No

SpneCM_010100004332

298254829

ABC transporter substrate-binding protei...

80

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1XT8

41.2%

Streptococcus pneumoniae

IDP91967
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100008960

298255704

amino acid ABC transporter, periplasmic ...

268

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1XT8

28.7%

Streptococcus pneumoniae

IDP05490
(show subtarget assignments)

1

soluble

No

BA_5139

30259623

sodC

superoxide dismutase, Cu-Zn [Bacillus an...

179

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XTM

35.2%

Bacillus anthracis

Cellular processes: Detoxification

IDP01703
(show subtarget assignments)

1

in_crystallization_trials

No

Cj1317

15792640

neuB3

N-acetylneuraminic acid synthetase [Camp...

343

Known Predicted virulence-O-linked flagellar glycoslyation; Predicted virulence-...

Phase 3: June 2008

1XUU

35.1%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02035
(show subtarget assignments)

1

cloned

No

Cj1141

15792466

neuB1

N-acetylneuraminic acid synthetase [Camp...

343

Known Predicted virulence-LOS-Immune evasion and molecular mimcry; Predicted Ess...

Phase 3: June 2008

1XUU

59%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01840
(show subtarget assignments)

1

soluble

No

STM2861

16766167

sitA

putative periplasmic binding protein [Sa...

305

Conserved; Drug target functions

Phase 3: June 2008

1XVL

53.4%

Salmonella enterica

Cell envelope

Other

IDP91001
(show subtarget assignments)

8

soluble

No

y1897

22125790

yfeA

periplasmic-binding protein [Yersinia pe...

323

virulence/pathogenesis / periplasmic iron-binding protein

Community Requests

1XVL

52.9%

Yersinia pestis

IDP00429
(show subtarget assignments)

1

purified

No

YPO2958

16123140

sfuA

iron(III)-binding periplasmic protein

339

Virulence Associated Factor

Phase 2: March 2008

1XVX

79.9%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP92075
(show subtarget assignments)

8

selected

No

TGME49_095690

237844421

ubiquinone/menaquinone biosynthesis meth...

392

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1XXL

8.2%

Toxoplasma gondii

IDP05583
(show subtarget assignments)

1

soluble

No

BA_2249

30256893

SCO1/SenC family lipoprotein [Bacillus a...

195

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1XZO

45.6%

Bacillus anthracis

Unknown function: General

IDP04649
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1283

56708343

trmE

tRNA modification GTPase TrmE [Francisel...

450

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1XZP

36.1%

Francisella tularensis

Protein synthesis

tRNA and rRNA base modification

IDP04120
(show subtarget assignments)

1

soluble

No

BAS1475

49184492

xanthine phosphoribosyltransferase [Baci...

197

Proposed to be essential proteins

Phase 4: April 2009

1Y0B

65%

Bacillus anthracis

IDP00084
(show subtarget assignments)

1

expressed

No

NT01ST1435

16419673

yceI

putative secreted protein

191

Essential

Phase 1: October 2007

1Y0G

91.1%

Salmonella enterica

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04073
(show subtarget assignments)

1

crystallized

No

YPO0502

115346311

conserved hypothetical protein [Yersinia...

172

virulence factor; conserved gene;

Phase 4: April 2009

1Y12

38.4%

Yersinia pestis

Hypothetical proteins

Conserved

IDP92114
(show subtarget assignments)

8

selected

No

TGME49_011330

237843941

methionine aminopeptidase, putative [Tox...

329

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1Y1N

36.8%

Toxoplasma gondii

IDP00840
(show subtarget assignments)

1

purified

No

SACOL1894

57284813

HIT family protein

140

Drug Target Function

Phase 2: March 2008

1Y23

52.1%

Staphylococcus aureus

Unknown function

General

IDP02690
(show subtarget assignments)

1

cloned

No

FTT0954c

56708048

hypothetical protein FTT0954c [Francisel...

106

Drug Target

Phase 3: June 2008

1Y2I

36.8%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP04416
(show subtarget assignments)

1

in_crystallization_trials

No

BAS4049

49187047

ribonuclease Z [Bacillus anthracis str. ...

307

Proposed to be essential proteins

Phase 4: April 2009

1Y44

61.2%

Bacillus anthracis

IDP01491
(show subtarget assignments)

1

soluble

No

VCA0603

15601361

ABC transporter, periplasmic substrate-b...

339

Conserved Gene / Pathway

Phase 2: March 2008

1Y4T

18.3%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP91956
(show subtarget assignments)

8

in_crystallization_trials

No

SpneCM_010100005733

298255095

ABC transporter, substrate-binding prote...

353

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1Y4T

19.8%

Streptococcus pneumoniae

IDP01227
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4268

30258770

ptsH-1

phosphocarrier protein HPr

87

Conserved Gene / Pathway

Phase 2: March 2008

1Y4Y

72.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00628
(show subtarget assignments)

1

cloned

No

SACOL0369

57285482

prophage L54a, Clp protease, putative

257

Drug Target Function

Phase 2: March 2008

1Y7O

22.2%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP91989
(show subtarget assignments)

8

purified

No

SpneCM_010100010148

298255940

serine protease [Streptococcus pneumonia...

393

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

1Y8T

32.1%

Streptococcus pneumoniae

IDP00460
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0914

16121219

serA

D-3-phosphoglycerate dehydrogenase

413

Virulence Associated Factor

Phase 2: March 2008

1YBA

83.8%

Yersinia pestis

Amino acid biosynthesis

Serine family

IDP02113
(show subtarget assignments)

1

in_crystallization_trials

No

STM3901

16767177

ilvG

acetolactate synthase 2 catalytic subuni...

548

Conserved; Drug target functions

Phase 3: June 2008

1YBH

46.7%

Salmonella enterica

Amino acid biosynthesis

Pyruvate family

IDP02296
(show subtarget assignments)

1

crystallized

No

GBAA0020

47525275

hypothetical protein GBAA0020 [Bacillus ...

109

Conserved; Involved in sporulation;

Phase 3: June 2008

1YBX

55.8%

Bacillus anthracis

Hypothetical proteins

Conserved

IDP91514
(show subtarget assignments)

8

expressed

No

VV2_1517

27367864

agglutination protein [Vibrio vulnificus...

436

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YC9

16.5%

Vibrio vulnificus

IDP02653
(show subtarget assignments)

1

in_crystallization_trials

No

STM2840

16766146

anaerobic nitric oxide reductase flavoru...

479

Conserved; Drug target functions

Phase 3: June 2008

1YCF

33.8%

Salmonella enterica

Energy metabolism

Electron transport

IDP90568
(show subtarget assignments)

8

soluble

No

Cj0536

15791897

oorA

2-oxoglutarate-acceptor oxidoreductase s...

374

Predicted Essential

Community Requests

1YD7

43%

Campylobacter jejuni

IDP01788
(show subtarget assignments)

1

crystallized

No

YPO3827

16123962

glpQ

glycerophosphodiester phosphodiesterase ...

371

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1YDY

71.7%

Yersinia pestis

Central intermediary metabolism

Other

IDP00806
(show subtarget assignments)

1

cloned

No

SACOL1861

57284782

hsdS

type I restriction-modification enzyme, ...

399

Drug Target Function

Phase 2: March 2008

1YF2

27.8%

Staphylococcus aureus

DNA metabolism

Restriction/modification

IDP04026
(show subtarget assignments)

1

expressed

No

FTT0456c

56707598

hypothetical protein FTT_0456c [Francise...

97

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YHD

39.2%

Francisella tularensis

IDP00957
(show subtarget assignments)

0

work_stopped

No

STM1202

16764557

ycfH

predicted metallodependent hydrolase

265

Conserved Gene / Pathway

Phase 2: March 2008

1YIX

92.8%

Salmonella enterica

Unknown function

Enzymes of unknown specificity

IDP91493
(show subtarget assignments)

8

cloned

No

VP1690

28898464

putative type III secretion lipoprotein ...

248

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YJ7

23.8%

Vibrio parahaemolyticus

IDP92023
(show subtarget assignments)

8

selected

No

TGME49_010260

237845081

glycerol-3-phosphate dehydrogenase, puta...

515

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1YJ8

33.2%

Toxoplasma gondii

IDP02541
(show subtarget assignments)

1

expressed

No

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP04112
(show subtarget assignments)

1

cloned

No

YPO2626

115348318

nagA

putative N-acetylglucosamine-6-phosphate...

381

drug target; putative drug target function;

Phase 4: April 2009

1YMY

75.1%

Yersinia pestis

Central intermediary metabolism

Amino sugars

IDP05238
(show subtarget assignments)

1

cloned

No

lmo1799

16803839

-

peptidoglycan binding protein [Listeria ...

903

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YO8

10%

Listeria monocytogenes

Cell envelope: Other

IDP05536
(show subtarget assignments)

1

cloned

No

CD3145

126700762

putative serine-aspartate-rich surface a...

1190

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YO8

7.6%

Clostridium difficile

Unknown function: General

IDP05585
(show subtarget assignments)

1

soluble

No

Z0801

12513558

ybeK

putative tRNA synthetase [Escherichia co...

311

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1YOE

99.4%

Escherichia coli

Protein synthesis: tRNA aminoacylation

IDP90126
(show subtarget assignments)

8

expressed

No

MPXV_ZAI1979_005_044

68449118

unknown [Monkeypox virus]

212

thiol substrate, similar to VACV-COP-F9L, MPXV-ZAI96-C15L

Community Requests

1YPY

21.7%

Monkeypox virus

IDP02259
(show subtarget assignments)

1

cloned

No

GBAA2164

47527458

ABC transporter ATP-binding protein [Bac...

631

Conserved; Drug target functions

Phase 3: June 2008

1YQT

21.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01695
(show subtarget assignments)

1

expressed

No

GBAA0228

47525485

ABC transporter ATP-binding protein [Bac...

626

Conserved; Drug target functions

Phase 3: June 2008

1YQT

20.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP01667
(show subtarget assignments)

1

expressed

No

FTT1782c

56708774

yjjK

putative ABC transporter ATP-binding pro...

559

Conserved; Drug target functions

Phase 3: June 2008

1YQT

27.3%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01301
(show subtarget assignments)

1

expressed

No

VC0170

15640200

peptide ABC transporter, ATP-binding pro...

571

Conserved Gene / Pathway

Phase 2: March 2008

1YQT

22.4%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP00065
(show subtarget assignments)

1

expressed

No

BA_5409

30259882

macrolide efflux pump, putative

544

Virulence

Phase 1: October 2007

1YQT

24.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP05496
(show subtarget assignments)

1

soluble

No

BA_4047

30258554

cell division protein FtsQ [Bacillus ant...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YR1

15.5%

Bacillus anthracis

Cellular processes: Cell division

IDP90565
(show subtarget assignments)

8

soluble

No

VC0162

15640192

ketol-acid reductoisomerase [Vibrio chol...

494

Predicted Essential

Community Requests

1YRL

75.3%

Vibrio cholerae

IDP04613
(show subtarget assignments)

1

cloned

No

BAS3890

49186888

M20/M25/M40 family peptidase [Bacillus a...

376

Proposed to be essential proteins

Phase 4: April 2009

1YSJ

35.6%

Bacillus anthracis

IDP00695
(show subtarget assignments)

1

purified

No

SACOL2322

57285057

peptidase, M20/M25/M40 family

373

Drug Target Function

Phase 2: March 2008

1YSJ

41.3%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP04647
(show subtarget assignments)

1

purified

No

FTT1127

56604696

Rhodanese-like family protein [Francisel...

252

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YT8

18.3%

Francisella tularensis

IDP91716
(show subtarget assignments)

8

selected

No

NP_009330

6274552

STAT1

signal transducer and activator of trans...

750

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1YVL

91.1%

Homo sapiens

IDP91706
(show subtarget assignments)

8

selected

No

NP_005410

4885615

STAT2

signal transducer and activator of trans...

851

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

1YVL

36%

Homo sapiens

IDP01351
(show subtarget assignments)

1

cloned

No

VCA0387

15601150

toxin resistance protein

169

Conserved Gene / Pathway

Phase 2: March 2008

1YVO

31.4%

Vibrio cholerae

Cellular processes

Toxin production and resistance

IDP02447
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0561

16802604

hisE

phosphoribosyl-ATP pyrophosphatase [List...

103

Predicted Essential-Modeling; DNA binding Motifs

Phase 3: June 2008

1YVW

54.4%

Listeria monocytogenes

Amino acid biosynthesis

Histidine family

IDP04094
(show subtarget assignments)

1

expressed

No

YPO1966

218929080

astE

succinylglutamate desuccinylase [Yersini...

330

conserved gene; putative drug target function;

Phase 4: April 2009

1YW6

47.9%

Yersinia pestis

Unclassified

Role category not yet assigned

IDP05691
(show subtarget assignments)

1

cloned

No

lmo1800

16803840

-

hypothetical protein lmo1800 [Listeria m...

298

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YWF

25.8%

Listeria monocytogenes

Energy metabolism: Sugars

IDP02472
(show subtarget assignments)

1

in_crystallization_trials

No

YPO3785

16123919

hypothetical protein YPO3785 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1YWF

26.2%

Yersinia pestis

Energy metabolism

Sugars

IDP05291
(show subtarget assignments)

1

in_crystallization_trials

No

CD1211

126698807

putative acetyltransferase [Clostridium ...

163

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

1YX0

23.9%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP91382
(show subtarget assignments)

8

purified

No

VV1_1470

27364854

histone acetyltransferase HPA2 [Vibrio v...

164

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YX0

18.9%

Vibrio vulnificus

IDP04614
(show subtarget assignments)

1

purified

No

BAS4131

49187128

glycine cleavage system aminomethyltrans...

366

Proposed to be essential proteins

Phase 4: April 2009

1YX2

66.1%

Bacillus anthracis

IDP02808
(show subtarget assignments)

1

cloned

No

STM1084

16764443

yccK

sulfurtransferase TusE [Salmonella typhi...

109

Conserved; Drug target functions

Phase 3: June 2008

1YX3

47.7%

Salmonella enterica

Unknown function

General

IDP91365
(show subtarget assignments)

8

soluble

No

VV1_2710

27366000

dissimilatory sulfite reductase, gamma s...

109

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1YX3

48.6%

Vibrio vulnificus

IDP04616
(show subtarget assignments)

1

in_crystallization_trials

No

BAS4313

49187308

S-adenosylmethionine:tRNA ribosyltransfe...

350

Proposed to be essential proteins

Phase 4: April 2009

1YY3

71.4%

Bacillus anthracis

IDP01516
(show subtarget assignments)

1

crystallized

No

VC0576

15640598

sspA

stringent starvation protein A

211

Conserved Gene / Pathway

Phase 2: March 2008

1YY7

73.9%

Vibrio cholerae

Cellular processes

Adaptations to atypical conditions

IDP00354
(show subtarget assignments)

1

cloned

No

lmo2471

16804509

hypothetical protein lmo2471

338

Drug Target Function

Phase 2: March 2008

1Z41

62.4%

Listeria monocytogenes

Fatty acid and phospholipid metabolism

Degradation

IDP00701
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0149

57285352

cap5N

capsular polysaccharide biosynthesis pro...

295

Conserved Gene / Pathway

Phase 2: March 2008

1Z45

22.4%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01066
(show subtarget assignments)

1

expressed

No

STM3819

16767104

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP02381
(show subtarget assignments)

1

expressed

No

GBAA2279

47527580

proV-1

glycine betaine/L-proline ABC transporte...

315

Conserved; Drug target functions

Phase 3: June 2008

1Z47

36.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP00972
(show subtarget assignments)

1

expressed

No

STM1743

16765087

oppD

oligopeptide transporter ATP-binding com...

335

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

25.7%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00863
(show subtarget assignments)

1

expressed

No

STM2254

16765582

ccmA

heme exporter protein

205

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

32.7%

Salmonella enterica

Protein fate

Protein and peptide secretion and trafficking

IDP01671
(show subtarget assignments)

1

cloned

No

YPO3012

16123191

cysA

sulfate/thiosulfate transporter subunit ...

363

Conserved; CD; Drug target functions

Phase 3: June 2008

1Z47

39.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01669
(show subtarget assignments)

1

cloned

No

YPO3048

16123225

ABC transporter ATP-binding protein [Yer...

356

CD; Involved in virulence; Drug target functions

Phase 3: June 2008

1Z47

36.8%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP01654
(show subtarget assignments)

1

expressed

No

STM1259

16764611

putative ABC-type transport system ATPas...

196

Conserved; Drug target functions

Phase 3: June 2008

1Z47

31.6%

Salmonella enterica

Unclassified

Role category not yet assigned

IDP01390
(show subtarget assignments)

1

purified

No

VC0617

15640637

peptide ABC transporter, ATP-binding pro...

327

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

24.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP01149
(show subtarget assignments)

1

purified

No

BA_1195

30254908

oligopeptide ABC transporter, ATP-bindin...

311

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

30.2%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP90292
(show subtarget assignments)

8

cloned

No

TGGT1_004130

221483205

histone acetyltransferase GCN5, putative...

1169

The histone acetyltransferase TgGCN-5A acetylates prerentially Histone 3 [K18], ...

Community Requests

1Z4R

8.5%

Toxoplasma gondii

IDP01170
(show subtarget assignments)

1

cloned

No

BA_0165

30253674

prolyl oligopeptidase family protein, pu...

654

Drug Target Function

Phase 2: March 2008

1Z68

11.6%

Bacillus anthracis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP92090
(show subtarget assignments)

8

selected

No

TGME49_121570

237844801

(3R)-hydroxymyristoyl ACP dehydrase, put...

231

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1Z6B

35.9%

Toxoplasma gondii

IDP91002
(show subtarget assignments)

8

selected

No

y1919

22125812

bifunctional UDP-glucuronic acid decarbo...

667

virulence/pathogenesis / -

Community Requests

1Z7E

70.2%

Yersinia pestis

IDP02488
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1425

47526697

hisG

ATP phosphoribosyltransferase catalytic ...

211

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1Z7M

49.8%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP02668
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1526

47526800

gpsA

NAD(P)H-dependent glycerol-3-phosphate d...

340

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

1Z82

42.9%

Bacillus anthracis

Energy metabolism

Other

IDP90690
(show subtarget assignments)

8

purified

No

Cj1196c

15792520

gpsA

NAD(P)H-dependent glycerol-3-phosphate d...

298

Predicted Essential

Community Requests

1Z82

35.8%

Campylobacter jejuni

IDP05296
(show subtarget assignments)

1

purified

No

CD2138

126699755

pyrH

uridylate kinase [Clostridium difficile ...

234

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1Z9D

59.1%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP01674
(show subtarget assignments)

1

cloned

No

lmo2543

16804581

prfA

peptide chain release factor 1 [Listeria...

358

Predicted virulence-Regulation

Phase 3: June 2008

1ZBT

63.7%

Listeria monocytogenes

Protein synthesis

Translation factors

IDP00750
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2110

57286326

prfA

peptide chain release factor 1

358

Drug Target Function

Phase 2: March 2008

1ZBT

58.4%

Staphylococcus aureus

Protein synthesis

Translation factors

IDP04626
(show subtarget assignments)

1

cloned

No

BAS5178

49188164

peptide chain release factor 1 [Bacillus...

358

Proposed to be essential proteins

Phase 4: April 2009

1ZBT

59.2%

Bacillus anthracis

IDP02477
(show subtarget assignments)

1

cloned

No

YPO2035

16122274

hypothetical protein YPO2035 [Yersinia p...

276

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

1ZCC

23.6%

Yersinia pestis

Central intermediary metabolism

Other

IDP02094
(show subtarget assignments)

1

cloned

No

STM3598

16766884

putative L-asparaginase [Salmonella typh...

347

Conserved; Drug target functions

Phase 3: June 2008

1ZCF

68.9%

Salmonella enterica

Energy metabolism

Amino acids and amines

IDP04126
(show subtarget assignments)

1

cloned

No

YPO2871

115348542

guaB

inosine-5'-monophosphate dehydrogenase [...

487

conserved gene; putative drug target function;

Phase 4: April 2009

1ZFJ

56.1%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP90125
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_038

68449112

kelch-like protein [Monkeypox virus]

485

similar to VACV-COP-F3L, MPXV-ZAI96-C9L

Community Requests

1ZGK

13.6%

Monkeypox virus

IDP04119
(show subtarget assignments)

1

crystallized

No

BAS0131

49183165

adenylate kinase [Bacillus anthracis str...

216

Proposed to be essential proteins

Phase 4: April 2009

1ZIN

74.1%

Bacillus anthracis

IDP05663
(show subtarget assignments)

1

selected

No

lmo0333

16802378

-

hypothetical protein lmo0333 [Listeria m...

1778

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1ZIW

9.1%

Listeria monocytogenes

Cellular processes: Pathogenesis

IDP91877
(show subtarget assignments)

8

selected

No

CAB89086

7649401

fox-4

beta-lactamase class C [Escherichia coli...

382

potential drug target / Dissemination of plasmid-mediated class C ?-lactamases is currently a critical c...

Community Requests

1ZKJ

71.7%

Escherichia coli

IDP02417
(show subtarget assignments)

1

cloned

No

FTT0812

56707923

gcvH1

glycine cleavage system protein H [Franc...

126

Conserved; Drug target functions

Phase 3: June 2008

1ZKO

40.5%

Francisella tularensis

Energy metabolism

Amino acids and amines

IDP91821
(show subtarget assignments)

8

soluble

No

b2926

1789294

pgk

phosphoglycerate kinase [Escherichia col...

387

potential drug target / The following proteins are either GNAT acetyltransferases thought to acetylate p...

Community Requests

1ZMR

100%

Escherichia coli

IDP02688
(show subtarget assignments)

0

work_stopped

No

YPO0921

16121226

pgk

phosphoglycerate kinase [Yersinia pestis...

387

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

1ZMR

88.6%

Yersinia pestis

Energy metabolism

Glycolysis/gluconeogenesis

IDP91433
(show subtarget assignments)

8

in_crystallization_trials

No

VV1_0488

27363952

NTPase [Vibrio vulnificus CMCP6]

183

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1ZNO

68.3%

Vibrio vulnificus