Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP02387 (show subtarget assignments)	1	expressed	No	FTT1304c	56708362	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	282	Conserved; Drug target functions	Phase 3: June 2008	3TX1	33.7%	Francisella tularensis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01640 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4357	47529653		short chain dehydrogenase/reductase fami...	264	Conserved; Essential;	Phase 3: June 2008	3P19	33.7%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP90547 (show subtarget assignments)	8	crystallized	No	Cj1601	15792906	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	243	Predicted Essential	Community Requests	2X30	33.7%	Campylobacter jejuni

IDP90867 (show subtarget assignments)	8	in_crystallization_trials	No	YPO3850	16123985	hemD	uroporphyrinogen-III synthase [Yersinia ...	249	Predicted Essential	Community Requests	3MW8	33.7%	Yersinia pestis

IDP02304 (show subtarget assignments)	1	cloned	No	GBAA0703	47525984	qoxA	quinol oxidase, subunit II [Bacillus ant...	291	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1FFT	33.7%	Bacillus anthracis	Energy metabolism	Electron transport

IDP90999 (show subtarget assignments)	8	cloned	No	y1744	22125639		hypothetical protein y1744 [Yersinia pes...	95	other biological interest / -	Community Requests	1X7V	33.7%	Yersinia pestis

IDP05084 (show subtarget assignments)	1	in_crystallization_trials	No	Z4803	12518085		putative ATP-dependent DNA helicase (tog...	202	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1OYW	33.7%	Escherichia coli	DNA metabolism: DNA replication, recombination, and repair

IDP00655 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL0536	57285561	ksgA	dimethyladenosine transferase	297	Conserved Gene / Pathway	Phase 2: March 2008	3GRR	33.7%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP00140 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0197	30253704		pyrroline-5-carboxylate reductase, putat...	245	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3TRI	33.7%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02653 (show subtarget assignments)	1	in_crystallization_trials	No	STM2840	16766146		anaerobic nitric oxide reductase flavoru...	479	Conserved; Drug target functions	Phase 3: June 2008	1YCF	33.8%	Salmonella enterica	Energy metabolism	Electron transport

IDP91257 (show subtarget assignments)	8	soluble	No	NT02SA1359	14247140	trpD	anthranilate phosphoribosyltransferase [...	332	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VQU	33.8%	Staphylococcus aureus	Amino acid biosynthesis: Aromatic amino acid family

IDP05545 (show subtarget assignments)	1	cloned	No	Cj0845c	6968286	gltX	putative fructose-1,6-bisphosphatase [Ca...	431	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2O5R	33.8%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP90678 (show subtarget assignments)	8	crystallized	No	Cj0766c	15792104	tdk	thymidylate kinase [Campylobacter jejuni...	192	Predicted Essential	Community Requests	3HJN	33.8%	Campylobacter jejuni

IDP00965 (show subtarget assignments)	1	purified	No	STM1463	16764811	add	adenosine deaminase	333	Conserved Gene / Pathway	Phase 2: March 2008	1NDV	33.8%	Salmonella enterica	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP01925 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1846	16122097	fliY	cystine transporter subunit [Yersinia pe...	266	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2YLN	33.8%	Yersinia pestis	Cell envelope	Surface structures

IDP01782 (show subtarget assignments)	1	expressed	No	GBAA0752	47526035	scrK	fructokinase [Bacillus anthracis str. 'A...	313	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3EWM	33.8%	Bacillus anthracis	Energy metabolism	Sugars

IDP01772 (show subtarget assignments)	1	cloned	No	YPO3599	16123741	clpB2	Clp ATPase [Yersinia pestis CO92]	867	Drug target motif; CD; Drug target functions	Phase 3: June 2008	1QVR	33.8%	Yersinia pestis	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00819 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2161	57286374		UTP-glucose-1-phosphate uridylyltransfer...	395	Conserved Gene / Pathway	Phase 2: March 2008	1JV1	33.8%	Staphylococcus aureus	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01478 (show subtarget assignments)	1	purified	No	VC2772	15642765		ParB family protein	293	Conserved Gene / Pathway	Phase 2: March 2008	1VZ0	33.8%	Vibrio cholerae	Cellular processes	Cell division

IDP01394 (show subtarget assignments)	1	soluble	No	VC0700	15640719		soluble lytic murein transglycosylase	648	Drug Target Function	Phase 2: March 2008	1QSA	33.8%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05360 (show subtarget assignments)	1	cloned	No	BA_1623	30255921	rnhA	ribonuclease H [Bacillus anthracis str. ...	128	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3U3G	33.8%	Bacillus anthracis	Transcription: Degradation of RNA

IDP05274 (show subtarget assignments)	1	soluble	No	lmo1880	16803919	-	hypothetical protein lmo1880 [Listeria m...	133	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1JL2	33.8%	Listeria monocytogenes	Transcription: Degradation of RNA

IDP00643 (show subtarget assignments)	1	purified	No	SACOL2638	57286542		precorrin-2 dehydrogenase	201	Conserved Gene / Pathway	Phase 2: March 2008	3DFZ	33.8%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers	Heme, porphyrin, and cobalamin

IDP90903 (show subtarget assignments)	8	purified	No	VC0390	15640417	metH	B12-dependent methionine synthase [Vibri...	1226	Predicted Essential	Community Requests	3BUL	33.8%	Vibrio cholerae

IDP04426 (show subtarget assignments)	1	expressed	No	GBAA4339	47529636	bioF	8-amino-7-oxononanoate synthase [Bacillu...	395	putative drug target function;	Phase 4: April 2009	3A2B	33.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP01938 (show subtarget assignments)	1	purified	No	Cj1423c	15792741		putative sugar-phosphate nucleotidyltran...	221	Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749	Phase 3: June 2008	2GGO	33.9%	Campylobacter jejuni	Cell envelope	Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01876 (show subtarget assignments)	1	cloned	No	GBAA0095	47525349	secE	preprotein translocase subunit SecE [Bac...	59	Conserved; Essential; Involved in sporulation; Drug target functions	Phase 3: June 2008	3DIN	33.9%	Bacillus anthracis	Protein fate	Protein and peptide secretion and trafficking

IDP01834 (show subtarget assignments)	1	soluble	No	STM2345	16765672		putative transcriptional regulator [Salm...	339	Conserved; Drug target functions	Phase 3: June 2008	3H5O	33.9%	Salmonella enterica	Energy metabolism	Entner-Doudoroff

IDP04022 (show subtarget assignments)	1	cloned	No	BAS0095	49183129		preprotein translocase subunit SecE [Bac...	59	Proposed to be essential proteins	Phase 4: April 2009	3DIN	33.9%	Bacillus anthracis

IDP01699 (show subtarget assignments)	1	purified	No	YPO3343	16123493		extracellular solute-binding protein [Ye...	256	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3KBR	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP90670 (show subtarget assignments)	8	soluble	No	Cj1202	15792526	metF	5,10-methylenetetrahydrofolate reductase...	282	Predicted Essential	Community Requests	1V93	34%	Campylobacter jejuni

IDP05658 (show subtarget assignments)	1	cloned	No	lmo0207	16802253	-	hypothetical protein lmo0207 [Listeria m...	153	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2JOE	34%	Listeria monocytogenes	Viral functions: General

IDP01653 (show subtarget assignments)	1	cloned	No	GBAA4538	47529835	dnaJ	chaperone protein dnaJ [Bacillus anthrac...	371	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3LZ8	34%	Bacillus anthracis	Protein fate	Protein folding and stabilization

IDP01490 (show subtarget assignments)	1	expressed	No	VCA0602	15601360		ABC transporter, ATP-binding protein	403	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	34%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP01421 (show subtarget assignments)	1	soluble	No	VC1544	15641552		tonB2 protein	206	Conserved Gene / Pathway	Phase 2: March 2008	2K9K	34%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP04558 (show subtarget assignments)	8	selected	No	CAC05811	12329080	mxiG	MxiG, component of the Mxi-Spa secretion...	371	Shigella effector protein	Community Requests	4A4Y	34%	Shigella flexneri

IDP02039 (show subtarget assignments)	1	expressed	No	YPO1198	16121491		putative ABC transport ATP-binding subun...	312	Conserved; CD; Drug target functions	Phase 3: June 2008	1V43	34%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00545 (show subtarget assignments)	1	cloned	No	YPO2747	16122951	fadJ	multifunctional fatty acid oxidation com...	774	Conserved Gene / Pathway	Phase 2: March 2008	1WDK	34.1%	Yersinia pestis	Cellular processes	Detoxification

IDP00057 (show subtarget assignments)	1	soluble	No	BA_3900	30258414		lantibiotic biosynthesis DNA-binding res...	220	Virulence	Phase 1: October 2007	2GWR	34.1%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP01961 (show subtarget assignments)	1	soluble	No	STM1692	16765035	sapA	peptide transport protein [Salmonella ty...	549	Conserved; Drug target functions	Phase 3: June 2008	1DPP	34.1%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02779 (show subtarget assignments)	1	in_crystallization_trials	No	FTT1405c	56708453	gloB	hydroxyacylglutathione hydrolase [Franci...	252	Conserved; Drug target functions	Phase 3: June 2008	2QED	34.1%	Francisella tularensis	Energy metabolism	Other

IDP01854 (show subtarget assignments)	1	expressed	No	STM1246	16764600	pagC	virulence membrane protein PAGC precurso...	185	Conserved; Drug target functions	Phase 3: June 2008	1ORM	34.1%	Salmonella enterica	Cellular processes	Pathogenesis

IDP02176 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1002	29541584	birA	birA bifunctional protein [Coxiella burn...	323	Conserved; Drug target functions	Phase 3: June 2008	1BIA	34.1%	Coxiella burnetii	Regulatory functions	DNA interactions

IDP01601 (show subtarget assignments)	1	expressed	No	CBU_0746	29541346		ABC transporter, ATP-binding protein [Co...	249	Conserved; Drug target functions	Phase 3: June 2008	3FVQ	34.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP90742 (show subtarget assignments)	8	crystallized	No	Cj0947c	15792276		hydrolase, carbon-nitrogen family [Campy...	290	Predicted Essential	Community Requests	3IVZ	34.1%	Campylobacter jejuni

IDP01488 (show subtarget assignments)	1	in_crystallization_trials	No	VCA0572	15601331	ddl	D-alanyl-alanine synthetase A	334	Conserved Gene / Pathway	Phase 2: March 2008	2FB9	34.1%	Vibrio cholerae	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01443 (show subtarget assignments)	1	soluble	No	VC2061	15642061		ParA family protein	258	Conserved Gene / Pathway	Phase 2: March 2008	1WCV	34.1%	Vibrio cholerae	Cellular processes	Cell division

IDP00344 (show subtarget assignments)	1	cloned	No	lmo2039	16804078	pbpB	hypothetical protein lmo2039	751	Drug Target Function	Phase 2: March 2008	1RP5	34.1%	Listeria monocytogenes	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04090 (show subtarget assignments)	1	crystallized	No	CPF_0694	110800453	aroK	shikimate kinase [Clostridium perfringen...	167	conserved gene; putative drug target function;	Phase 4: April 2009	2PT5	34.1%	Clostridium perfringens	Amino acid biosynthesis	Aromatic amino acid family

IDP01942 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1745	16803785		hypothetical protein lmo1745 [Listeria m...	225	Known virulence-Regulation; PMID:16102006	Phase 3: June 2008	2OQR	34.2%	Listeria monocytogenes	Regulatory functions	Other

IDP00847 (show subtarget assignments)	1	expressed	No	SACOL1404	57284558	trpG	anthranilate synthase, glutamine amidotr...	188	Drug Target Function	Phase 2: March 2008	1QDL	34.2%	Staphylococcus aureus	Amino acid biosynthesis	Aromatic amino acid family

IDP01609 (show subtarget assignments)	1	crystallized	No	FTT1512c	56708550	dnaJ1	heat shock protein, hsp40 [Francisella t...	308	Conserved; Drug target functions	Phase 3: June 2008	3LZ8	34.2%	Francisella tularensis	Protein fate	Protein folding and stabilization

IDP02346 (show subtarget assignments)	1	cloned	No	GBAA2832	47528125	dapA-1	dihydrodipicolinate synthase [Bacillus a...	298	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	3NA8	34.2%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP91071 (show subtarget assignments)	8	cloned	No	NGO2165	59719354		putative ABC transporter, ATP-binding pr...	622	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3B5Y	34.2%	Neisseria gonorrhoeae

IDP01309 (show subtarget assignments)	1	purified	No	VC2078	15642078		ferrous iron transport protein A	76	Drug Target Function	Phase 2: March 2008	2K5I	34.2%	Vibrio cholerae	Transport and binding proteins	Cations and iron carrying compounds

IDP02593 (show subtarget assignments)	1	expressed	No	YPO3426	16123575	hofB	hypothetical protein YPO3426 [Yersinia p...	512	Conserved; CD; Drug target functions	Phase 3: June 2008	1P9R	34.2%	Yersinia pestis	Cell envelope	Surface structures

IDP04651 (show subtarget assignments)	1	cloned	No	FTT1417	56708464		carbon-nitrogen hydrolase [Francisella t...	261	drug target; conserved gene;	Phase 4: April 2009	2E11	34.3%	Francisella tularensis

IDP90747 (show subtarget assignments)	8	soluble	No	Cj0001	15791400	dnaA	chromosomal replication initiation prote...	440	Predicted Essential	Community Requests	2Z4R	34.3%	Campylobacter jejuni

IDP91205 (show subtarget assignments)	8	soluble	No	BT_3975	29349383		3-dehydroquinate synthase [Bacteroides t...	353	potential drug target / Shikimate pathway enzyme	Community Requests	3CLH	34.3%	Bacteroides thetaiotaomicron

IDP91449 (show subtarget assignments)	8	expressed	No	VV1_0390	27363858		SOS-response transcriptional repressor L...	137	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1I4V	34.3%	Vibrio vulnificus

IDP04225 (show subtarget assignments)	8	cloned	No	CAC05803	12329072	ipaB	IpaB, secreted by the Mxi-Spa secretion ...	580	Shigella effector protein	Community Requests	3U0C	34.3%	Shigella flexneri

IDP90852 (show subtarget assignments)	8	expressed	No	VC2018	15642020		4-amino-4-deoxychorismate lyase [Vibrio ...	277	Predicted Essential	Community Requests	1ET0	34.3%	Vibrio cholerae

IDP90939 (show subtarget assignments)	8	expressed	No	NMPDR 243277.1.peg.3882				198	Predicted Essential	Community Requests	2AU3	34.3%	Vibrio cholerae

IDP00316 (show subtarget assignments)	1	in_crystallization_trials	No	CBU_1152	29654458	trpE	anthranilate synthase component I	463	Drug Target Function	Phase 2: March 2008	1QDL	34.3%	Coxiella burnetii	Amino acid biosynthesis	Aromatic amino acid family

IDP90728 (show subtarget assignments)	8	cloned	No	YPO1412	16121692	asnC	asparaginyl-tRNA synthetase [Yersinia pe...	466	Predicted Essential	Community Requests	1X54	34.3%	Yersinia pestis

IDP90749 (show subtarget assignments)	8	in_crystallization_trials	No	Cj1641	15792946	murE	UDP-N-acetylmuramoylalanyl-D-glutamate--...	427	Predicted Essential	Community Requests	2WTZ	34.4%	Campylobacter jejuni

IDP01052 (show subtarget assignments)	1	expressed	No	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04572 (show subtarget assignments)	1	soluble	No	BAS0005	49183044		DNA gyrase subunit B [Bacillus anthracis...	640	Proposed to be essential proteins	Phase 4: April 2009	1EI1	34.4%	Bacillus anthracis

IDP91870 (show subtarget assignments)	8	selected	No	CAA30578	38663		unnamed protein product [Acinetobacter b...	259	drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation	Community Requests	2BKK	34.4%	Acinetobacter baumannii

IDP00516 (show subtarget assignments)	1	purified	No	YPO4022	16124145		putative iron transport protein	317	Conserved Gene / Pathway	Phase 2: March 2008	3GFV	34.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00961 (show subtarget assignments)	1	expressed	No	STM1385	16764735	ttrB	tetrathionate reductase complex subunit ...	250	Conserved Gene / Pathway	Phase 2: March 2008	2VPW	34.4%	Salmonella enterica	Energy metabolism	Electron transport

IDP90651 (show subtarget assignments)	8	expressed	No	YPO3314	16123467		putative N-terminal region of transketol...	276	Predicted Essential	Community Requests	3OOY	34.4%	Yersinia pestis

IDP90616 (show subtarget assignments)	8	selected	No	VC1054	15641067		DNA polymerase III subunits gamma and ta...	692	Predicted Essential	Community Requests	1JR3	34.5%	Vibrio cholerae

IDP92140 (show subtarget assignments)	8	selected	No	TGME49_072740	237833217		DNA-directed RNA polymerase III subunit,...	1332	potential drug target / TDR Toxoplasma Targets (Phase III)	Community Requests	1I3Q	34.5%	Toxoplasma gondii

IDP01464 (show subtarget assignments)	1	soluble	No	VC2520	15642516		ABC transporter, ATP-binding protein	267	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	34.5%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP91477 (show subtarget assignments)	8	expressed	No	VPA1338	28901193		putative ATPase YscN [Vibrio parahaemoly...	420	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	2DPY	34.5%	Vibrio parahaemolyticus

IDP02768 (show subtarget assignments)	1	purified	No	GBAA4689	47529988	folC	folylpolyglutamate synthase [Bacillus an...	433	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1O5Z	34.6%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Folic acid

IDP02180 (show subtarget assignments)	1	cloned	No	Cj0299	15791667		putative periplasmic beta-lactamase [Cam...	257	Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...	Phase 3: June 2008	1E3U	34.6%	Campylobacter jejuni	Transport and binding proteins	Anions

IDP02153 (show subtarget assignments)	1	expressed	No	CBU_0884	29541475	bipA	virulence regulator BipA [Coxiella burne...	602	Conserved; Drug target functions	Phase 3: June 2008	3E3X	34.6%	Coxiella burnetii	Cellular processes	Pathogenesis

IDP91266 (show subtarget assignments)	8	cloned	No	NT05BA1576	49178391		birA bifunctional protein [Bacillus anth...	326	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3RIR	34.6%	Bacillus anthracis	Regulatory functions: Other

IDP02112 (show subtarget assignments)	1	cloned	No	FTT1024c	56708113	yhbG	ABC transporter, ATP-binding protein [Fr...	243	Conserved; Drug target functions	Phase 3: June 2008	1JI0	34.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP04004 (show subtarget assignments)	1	cloned	No	CPF_1305	110799423	mtnN	5'-methylthioadenosine/S-adenosylhomocys...	266	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3EEI	34.6%	Clostridium perfringens	Central intermediary metabolism	Other

IDP04653 (show subtarget assignments)	1	expressed	No	FTT1503	56708541	xerC	integrase/recombinase XerC [Francisella ...	292	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1A0P	34.6%	Francisella tularensis	DNA metabolism	DNA replication, recombination, and repair

IDP05513 (show subtarget assignments)	1	cloned	No	CD0278	126697850		putative transcriptional regulator [Clos...	130	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4A5M	34.6%	Clostridium difficile	Regulatory functions: DNA interactions

IDP01145 (show subtarget assignments)	1	expressed	No	BA_0188	30253695		oligopeptide ABC transporter, ATP-bindin...	257	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	34.6%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01047 (show subtarget assignments)	1	cloned	No	STM3152	16766452		putative methyl-accepting chemotaxis pro...	547	Conserved Gene / Pathway	Phase 2: March 2008	3ZX6	34.7%	Salmonella enterica	Cellular processes	Chemotaxis and motility

IDP02650 (show subtarget assignments)	1	expressed	No	YPO3962	16124090		sugar-binding transport protein [Yersini...	314	Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...	Phase 3: June 2008	2IOY	34.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00818 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2148	57286362		PTS system, mannitol-specific IIA compon...	144	Drug Target Function	Phase 2: March 2008	1A3A	34.7%	Staphylococcus aureus	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP90297 (show subtarget assignments)	8	purified	No	TGME49_065450	211966338		hexokinase [Toxoplasma gondii ME49]	468	Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...	Community Requests	1CZA	34.7%	Toxoplasma gondii

IDP01448 (show subtarget assignments)	1	cloned	No	VC2213	15642211		outer membrane protein OmpA	321	Conserved Gene / Pathway	Phase 2: March 2008	3NB3	34.7%	Vibrio cholerae	Cell envelope	Other

IDP01213 (show subtarget assignments)	1	expressed	No	BA_3251	30257808		3-oxoacyl-(acyl-carrier-protein) synthas...	329	Drug Target Function	Phase 2: March 2008	2EBD	34.7%	Bacillus anthracis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP91893 (show subtarget assignments)	8	selected	No	SpneCM_010100003665	298254698		ABC transporter, ATP-binding protein [St...	580	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	2HYD	34.8%	Streptococcus pneumoniae

IDP05052 (show subtarget assignments)	1	expressed	No	CD0239	126697810	fliC	flagellin subunit [Clostridium difficile...	290	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3K8W	34.8%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP01873 (show subtarget assignments)	1	cloned	No	FTT0917	56708018	maeA	malate dehydrogenase [Francisella tulare...	604	Drug Target	Phase 3: June 2008	2AW5	34.8%	Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP05236 (show subtarget assignments)	1	crystallized	No	lmo1533	16803573	ruvA	hypothetical protein lmo1533 [Listeria m...	201	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1IXR	34.8%	Listeria monocytogenes	DNA metabolism: DNA replication, recombination, and repair

IDP00306 (show subtarget assignments)	1	expressed	No	CBU_0137	29653495	murB	UDP-N-acetylenolpyruvoylglucosamine redu...	316	Drug Target Function	Phase 2: March 2008	3TX1	34.8%	Coxiella burnetii	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02798 (show subtarget assignments)	1	purified	No	GBAA5049	47530348		carbonic anhydrase [Bacillus anthracis s...	187	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1G5C	34.8%	Bacillus anthracis	Central intermediary metabolism	Other

IDP00570 (show subtarget assignments)	1	expressed	No	YPO2042	16122281		putative oxidoreductase	536	Conserved Gene / Pathway	Phase 2: March 2008	1TLT	34.9%	Yersinia pestis	Cellular processes	Pathogenesis

IDP91254 (show subtarget assignments)	8	soluble	No	NT02SA0910	14246689		probable 2-nitropropane dioxygenase [Sta...	355	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3BW2	34.9%	Staphylococcus aureus	Cellular processes: Detoxification

IDP04082 (show subtarget assignments)	1	cloned	No	YPO1596	115347343	plsX	fatty acid/phospholipid synthesis protei...	344	conserved gene; putative drug target function;	Phase 4: April 2009	1U7N	34.9%	Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP02387
(show subtarget assignments)

1

expressed

No

FTT1304c

56708362

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

282

Conserved; Drug target functions

Phase 3: June 2008

3TX1

33.7%

Francisella tularensis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01640
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4357

47529653

short chain dehydrogenase/reductase fami...

264

Conserved; Essential;

Phase 3: June 2008

3P19

33.7%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP90547
(show subtarget assignments)

8

crystallized

No

Cj1601

15792906

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

243

Predicted Essential

Community Requests

2X30

33.7%

Campylobacter jejuni

IDP90867
(show subtarget assignments)

8

in_crystallization_trials

No

YPO3850

16123985

hemD

uroporphyrinogen-III synthase [Yersinia ...

249

Predicted Essential

Community Requests

3MW8

33.7%

Yersinia pestis

IDP02304
(show subtarget assignments)

1

cloned

No

GBAA0703

47525984

qoxA

quinol oxidase, subunit II [Bacillus ant...

291

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1FFT

33.7%

Bacillus anthracis

Energy metabolism

Electron transport

IDP90999
(show subtarget assignments)

8

cloned

No

y1744

22125639

hypothetical protein y1744 [Yersinia pes...

95

other biological interest / -

Community Requests

1X7V

33.7%

Yersinia pestis

IDP05084
(show subtarget assignments)

1

in_crystallization_trials

No

Z4803

12518085

putative ATP-dependent DNA helicase (tog...

202

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1OYW

33.7%

Escherichia coli

DNA metabolism: DNA replication, recombination, and repair

IDP00655
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL0536

57285561

ksgA

dimethyladenosine transferase

297

Conserved Gene / Pathway

Phase 2: March 2008

3GRR

33.7%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP00140
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0197

30253704

pyrroline-5-carboxylate reductase, putat...

245

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3TRI

33.7%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02653
(show subtarget assignments)

1

in_crystallization_trials

No

STM2840

16766146

anaerobic nitric oxide reductase flavoru...

479

Conserved; Drug target functions

Phase 3: June 2008

1YCF

33.8%

Salmonella enterica

Energy metabolism

Electron transport

IDP91257
(show subtarget assignments)

8

soluble

No

NT02SA1359

14247140

trpD

anthranilate phosphoribosyltransferase [...

332

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VQU

33.8%

Staphylococcus aureus

Amino acid biosynthesis: Aromatic amino acid family

IDP05545
(show subtarget assignments)

1

cloned

No

Cj0845c

6968286

gltX

putative fructose-1,6-bisphosphatase [Ca...

431

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2O5R

33.8%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP90678
(show subtarget assignments)

8

crystallized

No

Cj0766c

15792104

tdk

thymidylate kinase [Campylobacter jejuni...

192

Predicted Essential

Community Requests

3HJN

33.8%

Campylobacter jejuni

IDP00965
(show subtarget assignments)

1

purified

No

STM1463

16764811

add

adenosine deaminase

333

Conserved Gene / Pathway

Phase 2: March 2008

1NDV

33.8%

Salmonella enterica

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP01925
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1846

16122097

fliY

cystine transporter subunit [Yersinia pe...

266

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2YLN

33.8%

Yersinia pestis

Cell envelope

Surface structures

IDP01782
(show subtarget assignments)

1

expressed

No

GBAA0752

47526035

scrK

fructokinase [Bacillus anthracis str. 'A...

313

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3EWM

33.8%

Bacillus anthracis

Energy metabolism

Sugars

IDP01772
(show subtarget assignments)

1

cloned

No

YPO3599

16123741

clpB2

Clp ATPase [Yersinia pestis CO92]

867

Drug target motif; CD; Drug target functions

Phase 3: June 2008

1QVR

33.8%

Yersinia pestis

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00819
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2161

57286374

UTP-glucose-1-phosphate uridylyltransfer...

395

Conserved Gene / Pathway

Phase 2: March 2008

1JV1

33.8%

Staphylococcus aureus

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01478
(show subtarget assignments)

1

purified

No

VC2772

15642765

ParB family protein

293

Conserved Gene / Pathway

Phase 2: March 2008

1VZ0

33.8%

Vibrio cholerae

Cellular processes

Cell division

IDP01394
(show subtarget assignments)

1

soluble

No

VC0700

15640719

soluble lytic murein transglycosylase

648

Drug Target Function

Phase 2: March 2008

1QSA

33.8%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05360
(show subtarget assignments)

1

cloned

No

BA_1623

30255921

rnhA

ribonuclease H [Bacillus anthracis str. ...

128

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3U3G

33.8%

Bacillus anthracis

Transcription: Degradation of RNA

IDP05274
(show subtarget assignments)

1

soluble

No

lmo1880

16803919

-

hypothetical protein lmo1880 [Listeria m...

133

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1JL2

33.8%

Listeria monocytogenes

Transcription: Degradation of RNA

IDP00643
(show subtarget assignments)

1

purified

No

SACOL2638

57286542

precorrin-2 dehydrogenase

201

Conserved Gene / Pathway

Phase 2: March 2008

3DFZ

33.8%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers

Heme, porphyrin, and cobalamin

IDP90903
(show subtarget assignments)

8

purified

No

VC0390

15640417

metH

B12-dependent methionine synthase [Vibri...

1226

Predicted Essential

Community Requests

3BUL

33.8%

Vibrio cholerae

IDP04426
(show subtarget assignments)

1

expressed

No

GBAA4339

47529636

bioF

8-amino-7-oxononanoate synthase [Bacillu...

395

putative drug target function;

Phase 4: April 2009

3A2B

33.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP01938
(show subtarget assignments)

1

purified

No

Cj1423c

15792741

putative sugar-phosphate nucleotidyltran...

221

Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749

Phase 3: June 2008

2GGO

33.9%

Campylobacter jejuni

Cell envelope

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP01876
(show subtarget assignments)

1

cloned

No

GBAA0095

47525349

secE

preprotein translocase subunit SecE [Bac...

59

Conserved; Essential; Involved in sporulation; Drug target functions

Phase 3: June 2008

3DIN

33.9%

Bacillus anthracis

Protein fate

Protein and peptide secretion and trafficking

IDP01834
(show subtarget assignments)

1

soluble

No

STM2345

16765672

putative transcriptional regulator [Salm...

339

Conserved; Drug target functions

Phase 3: June 2008

3H5O

33.9%

Salmonella enterica

Energy metabolism

Entner-Doudoroff

IDP04022
(show subtarget assignments)

1

cloned

No

BAS0095

49183129

preprotein translocase subunit SecE [Bac...

59

Proposed to be essential proteins

Phase 4: April 2009

3DIN

33.9%

Bacillus anthracis

IDP01699
(show subtarget assignments)

1

purified

No

YPO3343

16123493

extracellular solute-binding protein [Ye...

256

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3KBR

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP90670
(show subtarget assignments)

8

soluble

No

Cj1202

15792526

metF

5,10-methylenetetrahydrofolate reductase...

282

Predicted Essential

Community Requests

1V93

34%

Campylobacter jejuni

IDP05658
(show subtarget assignments)

1

cloned

No

lmo0207

16802253

-

hypothetical protein lmo0207 [Listeria m...

153

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2JOE

34%

Listeria monocytogenes

Viral functions: General

IDP01653
(show subtarget assignments)

1

cloned

No

GBAA4538

47529835

dnaJ

chaperone protein dnaJ [Bacillus anthrac...

371

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3LZ8

34%

Bacillus anthracis

Protein fate

Protein folding and stabilization

IDP01490
(show subtarget assignments)

1

expressed

No

VCA0602

15601360

ABC transporter, ATP-binding protein

403

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

34%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP01421
(show subtarget assignments)

1

soluble

No

VC1544

15641552

tonB2 protein

206

Conserved Gene / Pathway

Phase 2: March 2008

2K9K

34%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP04558
(show subtarget assignments)

8

selected

No

CAC05811

12329080

mxiG

MxiG, component of the Mxi-Spa secretion...

371

Shigella effector protein

Community Requests

4A4Y

34%

Shigella flexneri

IDP02039
(show subtarget assignments)

1

expressed

No

YPO1198

16121491

putative ABC transport ATP-binding subun...

312

Conserved; CD; Drug target functions

Phase 3: June 2008

1V43

34%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00545
(show subtarget assignments)

1

cloned

No

YPO2747

16122951

fadJ

multifunctional fatty acid oxidation com...

774

Conserved Gene / Pathway

Phase 2: March 2008

1WDK

34.1%

Yersinia pestis

Cellular processes

Detoxification

IDP00057
(show subtarget assignments)

1

soluble

No

BA_3900

30258414

lantibiotic biosynthesis DNA-binding res...

220

Virulence

Phase 1: October 2007

2GWR

34.1%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP01961
(show subtarget assignments)

1

soluble

No

STM1692

16765035

sapA

peptide transport protein [Salmonella ty...

549

Conserved; Drug target functions

Phase 3: June 2008

1DPP

34.1%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02779
(show subtarget assignments)

1

in_crystallization_trials

No

FTT1405c

56708453

gloB

hydroxyacylglutathione hydrolase [Franci...

252

Conserved; Drug target functions

Phase 3: June 2008

2QED

34.1%

Francisella tularensis

Energy metabolism

Other

IDP01854
(show subtarget assignments)

1

expressed

No

STM1246

16764600

pagC

virulence membrane protein PAGC precurso...

185

Conserved; Drug target functions

Phase 3: June 2008

1ORM

34.1%

Salmonella enterica

Cellular processes

Pathogenesis

IDP02176
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1002

29541584

birA

birA bifunctional protein [Coxiella burn...

323

Conserved; Drug target functions

Phase 3: June 2008

1BIA

34.1%

Coxiella burnetii

Regulatory functions

DNA interactions

IDP01601
(show subtarget assignments)

1

expressed

No

CBU_0746

29541346

ABC transporter, ATP-binding protein [Co...

249

Conserved; Drug target functions

Phase 3: June 2008

3FVQ

34.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP90742
(show subtarget assignments)

8

crystallized

No

Cj0947c

15792276

hydrolase, carbon-nitrogen family [Campy...

290

Predicted Essential

Community Requests

3IVZ

34.1%

Campylobacter jejuni

IDP01488
(show subtarget assignments)

1

in_crystallization_trials

No

VCA0572

15601331

ddl

D-alanyl-alanine synthetase A

334

Conserved Gene / Pathway

Phase 2: March 2008

2FB9

34.1%

Vibrio cholerae

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP01443
(show subtarget assignments)

1

soluble

No

VC2061

15642061

ParA family protein

258

Conserved Gene / Pathway

Phase 2: March 2008

1WCV

34.1%

Vibrio cholerae

Cellular processes

Cell division

IDP00344
(show subtarget assignments)

1

cloned

No

lmo2039

16804078

pbpB

hypothetical protein lmo2039

751

Drug Target Function

Phase 2: March 2008

1RP5

34.1%

Listeria monocytogenes

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP04090
(show subtarget assignments)

1

crystallized

No

CPF_0694

110800453

aroK

shikimate kinase [Clostridium perfringen...

167

conserved gene; putative drug target function;

Phase 4: April 2009

2PT5

34.1%

Clostridium perfringens

Amino acid biosynthesis

Aromatic amino acid family

IDP01942
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1745

16803785

hypothetical protein lmo1745 [Listeria m...

225

Known virulence-Regulation; PMID:16102006

Phase 3: June 2008

2OQR

34.2%

Listeria monocytogenes

Regulatory functions

Other

IDP00847
(show subtarget assignments)

1

expressed

No

SACOL1404

57284558

trpG

anthranilate synthase, glutamine amidotr...

188

Drug Target Function

Phase 2: March 2008

1QDL

34.2%

Staphylococcus aureus

Amino acid biosynthesis

Aromatic amino acid family

IDP01609
(show subtarget assignments)

1

crystallized

No

FTT1512c

56708550

dnaJ1

heat shock protein, hsp40 [Francisella t...

308

Conserved; Drug target functions

Phase 3: June 2008

3LZ8

34.2%

Francisella tularensis

Protein fate

Protein folding and stabilization

IDP02346
(show subtarget assignments)

1

cloned

No

GBAA2832

47528125

dapA-1

dihydrodipicolinate synthase [Bacillus a...

298

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

3NA8

34.2%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP91071
(show subtarget assignments)

8

cloned

No

NGO2165

59719354

putative ABC transporter, ATP-binding pr...

622

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3B5Y

34.2%

Neisseria gonorrhoeae

IDP01309
(show subtarget assignments)

1

purified

No

VC2078

15642078

ferrous iron transport protein A

76

Drug Target Function

Phase 2: March 2008

2K5I

34.2%

Vibrio cholerae

Transport and binding proteins

Cations and iron carrying compounds

IDP02593
(show subtarget assignments)

1

expressed

No

YPO3426

16123575

hofB

hypothetical protein YPO3426 [Yersinia p...

512

Conserved; CD; Drug target functions

Phase 3: June 2008

1P9R

34.2%

Yersinia pestis

Cell envelope

Surface structures

IDP04651
(show subtarget assignments)

1

cloned

No

FTT1417

56708464

carbon-nitrogen hydrolase [Francisella t...

261

drug target; conserved gene;

Phase 4: April 2009

2E11

34.3%

Francisella tularensis

IDP90747
(show subtarget assignments)

8

soluble

No

Cj0001

15791400

dnaA

chromosomal replication initiation prote...

440

Predicted Essential

Community Requests

2Z4R

34.3%

Campylobacter jejuni

IDP91205
(show subtarget assignments)

8

soluble

No

BT_3975

29349383

3-dehydroquinate synthase [Bacteroides t...

353

potential drug target / Shikimate pathway enzyme

Community Requests

3CLH

34.3%

Bacteroides thetaiotaomicron

IDP91449
(show subtarget assignments)

8

expressed

No

VV1_0390

27363858

SOS-response transcriptional repressor L...

137

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1I4V

34.3%

Vibrio vulnificus

IDP04225
(show subtarget assignments)

8

cloned

No

CAC05803

12329072

ipaB

IpaB, secreted by the Mxi-Spa secretion ...

580

Shigella effector protein

Community Requests

3U0C

34.3%

Shigella flexneri

IDP90852
(show subtarget assignments)

8

expressed

No

VC2018

15642020

4-amino-4-deoxychorismate lyase [Vibrio ...

277

Predicted Essential

Community Requests

1ET0

34.3%

Vibrio cholerae

IDP90939
(show subtarget assignments)

8

expressed

No

NMPDR 243277.1.peg.3882

198

Predicted Essential

Community Requests

2AU3

34.3%

Vibrio cholerae

IDP00316
(show subtarget assignments)

1

in_crystallization_trials

No

CBU_1152

29654458

trpE

anthranilate synthase component I

463

Drug Target Function

Phase 2: March 2008

1QDL

34.3%

Coxiella burnetii

Amino acid biosynthesis

Aromatic amino acid family

IDP90728
(show subtarget assignments)

8

cloned

No

YPO1412

16121692

asnC

asparaginyl-tRNA synthetase [Yersinia pe...

466

Predicted Essential

Community Requests

1X54

34.3%

Yersinia pestis

IDP90749
(show subtarget assignments)

8

in_crystallization_trials

No

Cj1641

15792946

murE

UDP-N-acetylmuramoylalanyl-D-glutamate--...

427

Predicted Essential

Community Requests

2WTZ

34.4%

Campylobacter jejuni

IDP01052
(show subtarget assignments)

1

expressed

No

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04572
(show subtarget assignments)

1

soluble

No

BAS0005

49183044

DNA gyrase subunit B [Bacillus anthracis...

640

Proposed to be essential proteins

Phase 4: April 2009

1EI1

34.4%

Bacillus anthracis

IDP91870
(show subtarget assignments)

8

selected

No

CAA30578

38663

unnamed protein product [Acinetobacter b...

259

drug resistance / confers resistance to aminoglycoside antibiotics by phosphorylation

Community Requests

2BKK

34.4%

Acinetobacter baumannii

IDP00516
(show subtarget assignments)

1

purified

No

YPO4022

16124145

putative iron transport protein

317

Conserved Gene / Pathway

Phase 2: March 2008

3GFV

34.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00961
(show subtarget assignments)

1

expressed

No

STM1385

16764735

ttrB

tetrathionate reductase complex subunit ...

250

Conserved Gene / Pathway

Phase 2: March 2008

2VPW

34.4%

Salmonella enterica

Energy metabolism

Electron transport

IDP90651
(show subtarget assignments)

8

expressed

No

YPO3314

16123467

putative N-terminal region of transketol...

276

Predicted Essential

Community Requests

3OOY

34.4%

Yersinia pestis

IDP90616
(show subtarget assignments)

8

selected

No

VC1054

15641067

DNA polymerase III subunits gamma and ta...

692

Predicted Essential

Community Requests

1JR3

34.5%

Vibrio cholerae

IDP92140
(show subtarget assignments)

8

selected

No

TGME49_072740

237833217

DNA-directed RNA polymerase III subunit,...

1332

potential drug target / TDR Toxoplasma Targets (Phase III)

Community Requests

1I3Q

34.5%

Toxoplasma gondii

IDP01464
(show subtarget assignments)

1

soluble

No

VC2520

15642516

ABC transporter, ATP-binding protein

267

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

34.5%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP91477
(show subtarget assignments)

8

expressed

No

VPA1338

28901193

putative ATPase YscN [Vibrio parahaemoly...

420

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

2DPY

34.5%

Vibrio parahaemolyticus

IDP02768
(show subtarget assignments)

1

purified

No

GBAA4689

47529988

folC

folylpolyglutamate synthase [Bacillus an...

433

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1O5Z

34.6%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Folic acid

IDP02180
(show subtarget assignments)

1

cloned

No

Cj0299

15791667

putative periplasmic beta-lactamase [Cam...

257

Predicted virulence-Resistance to antibiotics and toxic compounds; Possible Vacc...

Phase 3: June 2008

1E3U

34.6%

Campylobacter jejuni

Transport and binding proteins

Anions

IDP02153
(show subtarget assignments)

1

expressed

No

CBU_0884

29541475

bipA

virulence regulator BipA [Coxiella burne...

602

Conserved; Drug target functions

Phase 3: June 2008

3E3X

34.6%

Coxiella burnetii

Cellular processes

Pathogenesis

IDP91266
(show subtarget assignments)

8

cloned

No

NT05BA1576

49178391

birA bifunctional protein [Bacillus anth...

326

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3RIR

34.6%

Bacillus anthracis

Regulatory functions: Other

IDP02112
(show subtarget assignments)

1

cloned

No

FTT1024c

56708113

yhbG

ABC transporter, ATP-binding protein [Fr...

243

Conserved; Drug target functions

Phase 3: June 2008

1JI0

34.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP04004
(show subtarget assignments)

1

cloned

No

CPF_1305

110799423

mtnN

5'-methylthioadenosine/S-adenosylhomocys...

266

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3EEI

34.6%

Clostridium perfringens

Central intermediary metabolism

Other

IDP04653
(show subtarget assignments)

1

expressed

No

FTT1503

56708541

xerC

integrase/recombinase XerC [Francisella ...

292

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1A0P

34.6%

Francisella tularensis

DNA metabolism

DNA replication, recombination, and repair

IDP05513
(show subtarget assignments)

1

cloned

No

CD0278

126697850

putative transcriptional regulator [Clos...

130

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4A5M

34.6%

Clostridium difficile

Regulatory functions: DNA interactions

IDP01145
(show subtarget assignments)

1

expressed

No

BA_0188

30253695

oligopeptide ABC transporter, ATP-bindin...

257

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

34.6%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01047
(show subtarget assignments)

1

cloned

No

STM3152

16766452

putative methyl-accepting chemotaxis pro...

547

Conserved Gene / Pathway

Phase 2: March 2008

3ZX6

34.7%

Salmonella enterica

Cellular processes

Chemotaxis and motility

IDP02650
(show subtarget assignments)

1

expressed

No

YPO3962

16124090

sugar-binding transport protein [Yersini...

314

Conserved; CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target fun...

Phase 3: June 2008

2IOY

34.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00818
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2148

57286362

PTS system, mannitol-specific IIA compon...

144

Drug Target Function

Phase 2: March 2008

1A3A

34.7%

Staphylococcus aureus

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP90297
(show subtarget assignments)

8

purified

No

TGME49_065450

211966338

hexokinase [Toxoplasma gondii ME49]

468

Hexokinase (TgHK) is one of 5 major glycolytic enzymes characterized in Toxoplas...

Community Requests

1CZA

34.7%

Toxoplasma gondii

IDP01448
(show subtarget assignments)

1

cloned

No

VC2213

15642211

outer membrane protein OmpA

321

Conserved Gene / Pathway

Phase 2: March 2008

3NB3

34.7%

Vibrio cholerae

Cell envelope

Other

IDP01213
(show subtarget assignments)

1

expressed

No

BA_3251

30257808

3-oxoacyl-(acyl-carrier-protein) synthas...

329

Drug Target Function

Phase 2: March 2008

2EBD

34.7%

Bacillus anthracis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP91893
(show subtarget assignments)

8

selected

No

SpneCM_010100003665

298254698

ABC transporter, ATP-binding protein [St...

580

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

2HYD

34.8%

Streptococcus pneumoniae

IDP05052
(show subtarget assignments)

1

expressed

No

CD0239

126697810

fliC

flagellin subunit [Clostridium difficile...

290

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3K8W

34.8%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP01873
(show subtarget assignments)

1

cloned

No

FTT0917

56708018

maeA

malate dehydrogenase [Francisella tulare...

604

Drug Target

Phase 3: June 2008

2AW5

34.8%

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP05236
(show subtarget assignments)

1

crystallized

No

lmo1533

16803573

ruvA

hypothetical protein lmo1533 [Listeria m...

201

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1IXR

34.8%

Listeria monocytogenes

DNA metabolism: DNA replication, recombination, and repair

IDP00306
(show subtarget assignments)

1

expressed

No

CBU_0137

29653495

murB

UDP-N-acetylenolpyruvoylglucosamine redu...

316

Drug Target Function

Phase 2: March 2008

3TX1

34.8%

Coxiella burnetii

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP02798
(show subtarget assignments)

1

purified

No

GBAA5049

47530348

carbonic anhydrase [Bacillus anthracis s...

187

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1G5C

34.8%

Bacillus anthracis

Central intermediary metabolism

Other

IDP00570
(show subtarget assignments)

1

expressed

No

YPO2042

16122281

putative oxidoreductase

536

Conserved Gene / Pathway

Phase 2: March 2008

1TLT

34.9%

Yersinia pestis

Cellular processes

Pathogenesis

IDP91254
(show subtarget assignments)

8

soluble

No

NT02SA0910

14246689

probable 2-nitropropane dioxygenase [Sta...

355

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3BW2

34.9%

Staphylococcus aureus

Cellular processes: Detoxification

IDP04082
(show subtarget assignments)

1

cloned

No

YPO1596

115347343

plsX

fatty acid/phospholipid synthesis protei...

344

conserved gene; putative drug target function;

Phase 4: April 2009

1U7N

34.9%

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis