Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP91278 (show subtarget assignments)	8	cloned	No	NT05BA4419	49181159		RNA polymerase sigma-27 factor [Bacillus...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L9U	30.8%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP02456 (show subtarget assignments)	1	crystallized	No	GBAA3921	47529213	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	237	Conserved; Essential;	Phase 3: June 2008	2P68	38.1%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP02204 (show subtarget assignments)	1	cloned	No	Cj1462	6968880	Cj1452	putative integral membrane protein [Camp...	237	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008			Campylobacter jejuni	Cell envelope	Other

IDP04197 (show subtarget assignments)	1	expressed	No	CPF_2510	110799662		putative lipoprotein [Clostridium perfri...	237	drug target; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Cell envelope	Other

IDP01815 (show subtarget assignments)	1	soluble	No	CBU_1382	29541947	uppS	undecaprenyl diphosphate synthase [Coxie...	237	Conserved; Drug target functions	Phase 3: June 2008	1JP3	49.4%	Coxiella burnetii	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP91265 (show subtarget assignments)	8	cloned	No	NT05BA1551	49178367		2-heptaprenyl-1,4-naphthoquinone methylt...	237	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1VE3	24.9%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP02446 (show subtarget assignments)	1	in_crystallization_trials	No	lmo0287	16802333		hypothetical protein lmo0287 [Listeria m...	237	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2OQR	48.1%	Listeria monocytogenes	DNA metabolism	DNA replication, recombination, and repair

IDP05488 (show subtarget assignments)	1	cloned	No	BA_4789	30259275		putative LPXTG-motif cell wall anchor do...	237	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2K78	22.8%	Bacillus anthracis	Unknown function: General

IDP05421 (show subtarget assignments)	1	soluble	No	BAS1418	49184435	-	hypothetical protein BAS1418 [Bacillus a...	237	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05427 (show subtarget assignments)	1	cloned	No	lmo0585	16802628	-	putative secreted protein [Listeria mono...	237	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Hypothetical proteins: Conserved

IDP04362 (show subtarget assignments)	1	soluble	No	YPO3059	218930104	purC	phosphoribosylaminoimidazole-succinocarb...	237	conserved gene; putative drug target function;	Phase 4: April 2009	2GQR	86.9%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Purine ribonucleotide biosynthesis

IDP91666 (show subtarget assignments)	8	selected	No	NS1_I68A0	0			237	virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex	Community Requests	3F5T	77.2%	Influenza A

IDP91437 (show subtarget assignments)	8	soluble	No	VV1_0483	27363947		hypothetical protein VV1_0483 [Vibrio vu...	238	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	1U05	49.4%	Vibrio vulnificus

IDP91977 (show subtarget assignments)	8	selected	No	SpneCM_010100007810	298255490		D-alanyl-D-alanine carboxypeptidase [Str...	238	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests			Streptococcus pneumoniae

IDP91841 (show subtarget assignments)	8	selected	No	stu0182	55820280		MutR family transcriptional regulator [S...	238	virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...	Community Requests			Streptococcus thermophilus

IDP04421 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4022	47529315	pyrF	orotidine 5'-phosphate decarboxylase [Ba...	238	putative drug target function;	Phase 4: April 2009	1DBT	61.3%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides	Pyrimidine ribonucleotide biosynthesis

IDP02103 (show subtarget assignments)	1	expressed	No	YPO0891	16121196	dsbC	thiol:disulfide interchange protein DsbC...	238	Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...	Phase 3: June 2008	1JZD	61.8%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP00809 (show subtarget assignments)	1	cloned	No	SACOL1869	57284790	splA	serine protease SplA	238	Drug Target Function	Phase 2: March 2008	2W7S	84%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00791 (show subtarget assignments)	1	selected	No	SACOL1178	57284463		superantigen-like protein	238	Virulence Associated Factor	Phase 2: March 2008	1M4V	23.9%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP01468 (show subtarget assignments)	1	purified	No	VC2553	15642548		ABC transporter, ATP-binding protein, au...	238	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	32.8%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP91057 (show subtarget assignments)	8	cloned	No	USA300HOU_2035	161510252	agrA	accessory gene regulator protein A [Stap...	238	virulence/pathogenesis / The target is a drug target for anti-virulence therapy in infections of Methicil...	Community Requests	3BS1	42.9%	Staphylococcus aureus

IDP02557 (show subtarget assignments)	1	purified	No	Cj0061c	15791453	fliA	flagellar biosynthesis sigma factor [Cam...	238	Known Predicted virulence-flagella; PMID:8478066	Phase 3: June 2008	1RP3	35.3%	Campylobacter jejuni	Cellular processes	Chemotaxis and motility

IDP90416 (show subtarget assignments)	8	in_crystallization_trials	No	CT_538	3328976		hypothetical protein [Chlamydia trachoma...	238	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP05628 (show subtarget assignments)	1	soluble	No	CD1444	126699048		putative exported polysaccharide deacety...	239	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2C1G	32.6%	Clostridium difficile	Unknown function: General

IDP91272 (show subtarget assignments)	8	cloned	No	NT05BA3926	49180681		RNA polymerase sigma-29 factor [Bacillus...	239	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1L0O	31.4%	Bacillus anthracis

IDP01917 (show subtarget assignments)	1	soluble	No	GBAA1429	47526701	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	239	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1VZW	36.5%	Bacillus anthracis	Amino acid biosynthesis	Histidine family

IDP01625 (show subtarget assignments)	1	expressed	No	FTT1761	56708756		hypothetical protein FTT1761 [Francisell...	239	Drug Target	Phase 3: June 2008			Francisella tularensis	Unknown function	Enzymes of unknown specificity

IDP01505 (show subtarget assignments)	1	expressed	No	VCA1037	15601788		amino acid ABC transporter, ATP-binding ...	239	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	52.5%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP90224 (show subtarget assignments)	8	in_pdb 3I0U	No	CP0010	31983551	OspF	Shigella OspF effector	239	Shigella OspF effector	Community Requests	3I0U	90.8%	Shigella flexneri

IDP02541 (show subtarget assignments)	1	expressed	No	CBU_1709	29542267	dapB	dihydrodipicolinate reductase [Coxiella ...	239	Conserved; Drug target functions	Phase 3: June 2008	1YL5	42.3%	Coxiella burnetii	Amino acid biosynthesis	Aspartate family

IDP00641 (show subtarget assignments)	1	purified	No	SACOL1866	57284787		serine protease SplD, putative	239	Drug Target Function	Phase 2: March 2008	2VID	43.5%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP00638 (show subtarget assignments)	1	purified	No	SACOL2736	57285290	gidB	glucose-inhibited division protein B	239	Drug Target Function	Phase 2: March 2008	1XDZ	63.2%	Staphylococcus aureus	Unknown function	General

IDP00066 (show subtarget assignments)	1	expressed	No	NTL01CJ00766	6968259	kdsB	3-deoxy-manno-octulosonate cytidylyltran...	239	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2Y6P	40.2%	Campylobacter jejuni	Protein synthesis	tRNA aminoacylation

IDP90134 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_166	68449240		Toll/IL1-receptor [TIR]-like protein [Mo...	240	similar to VACV-COP-A46R, MPXV-ZAI96-A47R	Community Requests			Monkeypox virus

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02278 (show subtarget assignments)	1	expressed	No	Cj0045c	15791444		putative iron-binding protein [Campyloba...	240	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2AWC	13.7%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP00939 (show subtarget assignments)	1	expressed	No	STM0828	16764190	glnQ	glutamine ABC transporter ATP-binding pr...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00197 (show subtarget assignments)	1	purified	No	YPO1233	16121519	-	putative prophage repressor protein	240	Similar to Essential SALTY	Phase 1: October 2007	3BDN	46.2%	Yersinia pestis

IDP00093 (show subtarget assignments)	1	expressed	No	NT01SF0510	30040252	ybbF	hypothetical protein S0463	240	Essential	Phase 1: October 2007			Shigella flexneri	Unknown function	General

IDP00808 (show subtarget assignments)	1	cloned	No	SACOL1868	57284789	splB	serine protease SplB	240	Drug Target Function	Phase 2: March 2008	2VID	85%	Staphylococcus aureus	Protein fate	Degradation of proteins, peptides, and glycopeptides

IDP05023 (show subtarget assignments)	1	expressed	No	BAS2353	49185362	-	hemolysin II, C-terminal [Bacillus anthr...	240	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3ANZ	27.9%	Bacillus anthracis	Cellular processes: Pathogenesis

IDP90900 (show subtarget assignments)	8	cloned	No	YPO3075	16123252		UDP-2,3-diacylglucosamine hydrolase [Yer...	240	Predicted Essential	Community Requests			Yersinia pestis

IDP02578 (show subtarget assignments)	1	expressed	No	STM0262	16763645	yafS	putative SAM-dependent methyltransferase...	240	Conserved; Drug target functions	Phase 3: June 2008	1VLM	11.7%	Salmonella enterica	Unknown function	General

IDP02254 (show subtarget assignments)	1	cloned	No	FTT0766	56707880	deoD	purine nucleoside phosphorylase [Francis...	240	Drug Target	Phase 3: June 2008	1VHJ	43.3%	Francisella tularensis	Purines, pyrimidines, nucleosides, and nucleotides	Salvage of nucleosides and nucleotides

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01143 (show subtarget assignments)	1	in_pdb 3R8Y	No	BA_4194	30258698		2,3,4,5-tetrahydropyridine-2-carboxylate...	240	Drug Target Function	Phase 2: March 2008	3R8Y	100%	Bacillus anthracis	Amino acid biosynthesis	Aspartate family

IDP91435 (show subtarget assignments)	8	cloned	No	VV1_0485	27363949		DNA uptake lipoprotein [Vibrio vulnificu...	241	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3TGO	48.5%	Vibrio vulnificus

IDP00561 (show subtarget assignments)	0	work_stopped	No	YPO1046	16121346	pyrH	uridylate kinase	241	Conserved Gene / Pathway	Phase 2: March 2008	2BNE	90.5%	Yersinia pestis	Purines, pyrimidines, nucleosides, and nucleotides	Nucleotide and nucleoside interconversions

IDP02301 (show subtarget assignments)	1	cloned	No	FTT1249	56708311		cell entry (mce) related family protein ...	241	Drug Target	Phase 3: June 2008			Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP02002 (show subtarget assignments)	1	in_pdb 4E4Y	No	FTT1014c	56708103		short chain dehydrogenase family protein...	241	Drug Target	Phase 3: June 2008	4E4Y	100%	Francisella tularensis	Unclassified	Role category not yet assigned

IDP00933 (show subtarget assignments)	1	purified	No	STM0662	16764039	gltL	glutamate/aspartate transporter	241	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01465 (show subtarget assignments)	1	purified	No	VC2528	15642523		ABC transporter, ATP-binding protein	241	Conserved Gene / Pathway	Phase 2: March 2008	1JI0	33.6%	Vibrio cholerae	Transport and binding proteins	Unknown substrate

IDP00068 (show subtarget assignments)	0	work_stopped	No	NT01ST0271	16418722	pyrH	uridylate kinase	241	Essential	Phase 1: October 2007	2BNE	97.9%	Salmonella enterica	Amino acid biosynthesis	Glutamate family

IDP00282 (show subtarget assignments)	1	cloned	No	AAX48017_2243-2483	61652905	N/A	NS4B	241	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP00279 (show subtarget assignments)	1	selected	No	AAA99437_2243-2483	323469	N/A	NS4B	241	possibly RNA replication	Phase 3: June 2008			Dengue virus	Transcription	N/A

IDP04483 (show subtarget assignments)	1	expressed	No	YPO3361	115348990	b2747	4-diphosphocytidyl-2C-methyl-D-erythrito...	241	conserved gene; putative drug target function;	Phase 4: April 2009	1VGT	63.5%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Other

IDP90108 (show subtarget assignments)	8	soluble	No	MPXV_ZAI1979_005_013	68449087		bifunctional zinc finger-like protein/E3...	242	similar to VARV BEN68-zinc finger-like protein	Community Requests	2ECW	8.3%	Monkeypox virus

IDP91772 (show subtarget assignments)	8	expressed	No	AAR87481	40548828	sul3	dihydropteroate synthase [Escherichia co...	242	drug resistance / Dihydropteroate synthase (sulfonamide resistance)	Community Requests	1TWS	36.4%	Escherichia coli

IDP00944 (show subtarget assignments)	1	crystallized	No	STM0891	16764252	artP	arginine transporter ATP-binding subunit...	242	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	43.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01829 (show subtarget assignments)	1	cloned	No	lmo0051	16802099		hypothetical protein lmo0051 [Listeria m...	242	Known virulence-Regulation; PMID:17675424	Phase 3: June 2008	3BS1	15.7%	Listeria monocytogenes	Regulatory functions	Other

IDP05652 (show subtarget assignments)	1	cloned	No	lmo0129	16802177	-	hypothetical protein lmo0129 [Listeria m...	246	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3NE8	27.2%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91154 (show subtarget assignments)	8	in_pdb 3QFG	Yes	SAOUHSC_00808	88194568		hypothetical protein SAOUHSC_00808 [Stap...	242	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3QFG	93.4%	Staphylococcus aureus

IDP90176 (show subtarget assignments)	8	expressed	No	AAM13470.1	20153009	CPXV023 CDS	CPXV023 protein	242	zinc-finger-like protein	Community Requests	2ECW	8.3%	Cowpox virus	host defense modulator	0

IDP02370 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA1958	47527254	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	242	Conserved; Essential; Involved in sporulation;	Phase 3: June 2008	3OEC	40.9%	Bacillus anthracis	Unknown function	Enzymes of unknown specificity

IDP04687 (show subtarget assignments)	1	in_crystallization_trials	No	GBAA4340	47529637	bioD	dithiobiotin synthetase [Bacillus anthra...	242	putative drug target function;	Phase 4: April 2009	1A82	26.9%	Bacillus anthracis	Biosynthesis of cofactors, prosthetic groups, and carriers	Biotin

IDP90360 (show subtarget assignments)	8	in_crystallization_trials	No	CT_016	3328405		hypothetical protein [Chlamydia trachoma...	242	These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests			Chlamydia trachomatis

IDP00646 (show subtarget assignments)	1	selected	No	SACOL0887	57284346	sei	staphylococcal enterotoxin type I	242	Virulence Associated Factor	Phase 2: March 2008	2G9H	55%	Staphylococcus aureus	Cellular processes	Toxin production and resistance

IDP02474 (show subtarget assignments)	1	cloned	No	Cj0922c	15792251	pebC	amino acid ABC transporter ATP-binding p...	242	Predicted virulence-Adhesion of Campylobacter	Phase 3: June 2008	2OLJ	52.5%	Campylobacter jejuni	Hypothetical proteins	Conserved

IDP02438 (show subtarget assignments)	1	cloned	No	CBU_0029	29540654		acyltransferase family protein [Coxiella...	242	Conserved; Drug target functions	Phase 3: June 2008			Coxiella burnetii	Unknown function	Enzymes of unknown specificity

IDP90709 (show subtarget assignments)	8	cloned	No	YPO1215	16121506	ubiG	3-demethylubiquinone-9 3-methyltransfera...	242	Predicted Essential	Community Requests	3JWH	20.7%	Yersinia pestis

IDP02112 (show subtarget assignments)	1	cloned	No	FTT1024c	56708113	yhbG	ABC transporter, ATP-binding protein [Fr...	243	Conserved; Drug target functions	Phase 3: June 2008	1JI0	34.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP01012 (show subtarget assignments)	1	purified	No	STM2578	16765898	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Conserved Gene / Pathway	Phase 2: March 2008	1M5W	93.8%	Salmonella enterica	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP91784 (show subtarget assignments)	8	soluble	No	SA1480	15927234	ermA	rRNA methylase Erm(A) [Staphylococcus au...	243	drug resistance / rRNA methylase (macrolide-lincosamide-streptogramin B resistance protein)	Community Requests	1QAM	56.8%	Staphylococcus aureus

IDP00526 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1351	16121631	artI	arginine-binding periplasmic protein 1 p...	243	Conserved Gene / Pathway	Phase 2: March 2008	2Y7I	52.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP91473 (show subtarget assignments)	8	expressed	No	VPA1342	28901197		type III secretion system protein [Vibri...	243	virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio parahaemolyticus

IDP01901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0890	16764251	artI	arginine transport system [Salmonella ty...	243	Conserved; Drug target functions	Phase 3: June 2008	2Y7I	51.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP04210 (show subtarget assignments)	1	expressed	No	ZZZ_0017				243	Effector protein	Phase 4: April 2009	2KXC	18.5%	Escherichia coli

IDP02154 (show subtarget assignments)	1	expressed	No	GBAA2526	47527815		D-alanyl-D-alanine carboxypeptidase fami...	243	Drug target motif; Drug target functions	Phase 3: June 2008			Bacillus anthracis	Cell envelope	Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90547 (show subtarget assignments)	8	crystallized	No	Cj1601	15792906	hisA	1-(5-phosphoribosyl)-5-[(5-phosphoribosy...	243	Predicted Essential	Community Requests	2X30	33.7%	Campylobacter jejuni

IDP00439 (show subtarget assignments)	1	in_pdb 3F4N	No	YPO2930	16123117	pdxJ	pyridoxal phosphate biosynthetic protein...	243	Virulence Associated Factor	Phase 2: March 2008	3F4N	100%	Yersinia pestis	Biosynthesis of cofactors, prosthetic groups, and carriers	Pyridoxine

IDP04714 (show subtarget assignments)	1	expressed	No	YPO0672	218927865	parF	putative acyltransferase [Yersinia pesti...	243	conserved gene; putative drug target function;	Phase 4: April 2009			Yersinia pestis	Fatty acid and phospholipid metabolism	Biosynthesis

IDP01503 (show subtarget assignments)	1	soluble	No	VCA0978	15601731		amino acid ABC transporter, periplasmic ...	243	Conserved Gene / Pathway	Phase 2: March 2008	1HPB	26.3%	Vibrio cholerae	Transport and binding proteins	Amino acids, peptides and amines

IDP91235 (show subtarget assignments)	8	soluble	No	NT04EC1225	26107466		3-oxoacyl-[acyl-carrier protein] reducta...	243	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	4DML	44.4%	Escherichia coli	Fatty acid and phospholipid metabolism: Biosynthesis

IDP00696 (show subtarget assignments)	1	in_crystallization_trials	No	SACOL2410	57285141		amino acid ABC transporter, ATP-binding ...	243	Drug Target Function	Phase 2: March 2008	2OLJ	52.3%	Staphylococcus aureus	Transport and binding proteins	Amino acids, peptides and amines

IDP02064 (show subtarget assignments)	1	cloned	No	YPO3878	16124011		putative fimbrial chaperone [Yersinia pe...	243	CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions	Phase 3: June 2008	3Q48	32.5%	Yersinia pestis	Protein fate	Protein folding and stabilization

IDP91589 (show subtarget assignments)	8	expressed	No	BAB41266	13699967	ermA	rRNA methylase [Staphylococcus aureus su...	243	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1QAM	56.8%	Staphylococcus aureus

IDP90553 (show subtarget assignments)	8	soluble	No	VC2458	15642454		pyridoxal phosphate biosynthetic protein...	243	Predicted Essential	Community Requests	1M5W	70.8%	Vibrio cholerae

IDP01147 (show subtarget assignments)	1	expressed	No	BA_0639	30254242		amino acid ABC transporter, ATP-binding ...	243	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	60.5%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP00064 (show subtarget assignments)	1	cloned	No	BA_5200	30259683		transcriptional activator tipA, putative...	243	Virulence	Phase 1: October 2007	3QAO	56.2%	Bacillus anthracis	Cellular processes	Toxin production and resistance

IDP05054 (show subtarget assignments)	1	cloned	No	CD0250	126697821	fliH	flagellar assembly protein [Clostridium ...	243	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP00546 (show subtarget assignments)	1	expressed	No	YPO0359	16120694	frdB	fumarate reductase iron-sulfur subunit	244	Virulence Associated Factor	Phase 2: March 2008	1KF6	84.8%	Yersinia pestis	Energy metabolism	Anaerobic

IDP05739 (show subtarget assignments)	1	cloned	No	CD2136	126699752	uppS	undecaprenyl pyrophosphate synthetase [C...	244	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1F75	52.9%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90545 (show subtarget assignments)	8	soluble	No	YPO1599	16121867	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	244	Predicted Essential	Community Requests	1I01	86.9%	Yersinia pestis

IDP91030 (show subtarget assignments)	8	cloned	No	y3978	22127848		hypothetical protein y3978 [Yersinia pes...	244	other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...	Community Requests			Yersinia pestis

IDP02511 (show subtarget assignments)	1	soluble	No	CBU_1359	29541924	sufC	ABC transporter, ATP-binding protein [Co...	244	Conserved; Drug target functions	Phase 3: June 2008	2D3W	63.1%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04606 (show subtarget assignments)	1	cloned	No	BAS3692	49186691		tRNA (guanine-N(1)-)-methyltransferase [...	244	Proposed to be essential proteins	Phase 4: April 2009	3KY7	62.3%	Bacillus anthracis

IDP91290 (show subtarget assignments)	8	soluble	No	SPA1656	56413819	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	244	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I01	95.9%	Salmonella enterica

IDP91455 (show subtarget assignments)	8	cloned	No	VV1_0198	27363680		major facilitator superfamily permease [...	244	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP91297 (show subtarget assignments)	8	cloned	No	STM1195	16764550	fabG	3-ketoacyl-(acyl-carrier-protein) reduct...	244	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1I01	95.9%	Salmonella enterica

IDP02135 (show subtarget assignments)	1	in_pdb 3S81 3S7Z	Yes	STM4510	16767754		putative aspartate racemase [Salmonella ...	244	Conserved; Drug target functions	Phase 3: June 2008	3S7Z	100%	Salmonella enterica	Unknown function	General

IDP91278
(show subtarget assignments)

8

cloned

No

NT05BA4419

49181159

RNA polymerase sigma-27 factor [Bacillus...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L9U

30.8%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP02456
(show subtarget assignments)

1

crystallized

No

GBAA3921

47529213

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

237

Conserved; Essential;

Phase 3: June 2008

2P68

38.1%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP02204
(show subtarget assignments)

1

cloned

No

Cj1462

6968880

Cj1452

putative integral membrane protein [Camp...

237

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

Campylobacter jejuni

Cell envelope

Other

IDP04197
(show subtarget assignments)

1

expressed

No

CPF_2510

110799662

putative lipoprotein [Clostridium perfri...

237

drug target; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Cell envelope

Other

IDP01815
(show subtarget assignments)

1

soluble

No

CBU_1382

29541947

uppS

undecaprenyl diphosphate synthase [Coxie...

237

Conserved; Drug target functions

Phase 3: June 2008

1JP3

49.4%

Coxiella burnetii

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP91265
(show subtarget assignments)

8

cloned

No

NT05BA1551

49178367

2-heptaprenyl-1,4-naphthoquinone methylt...

237

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1VE3

24.9%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP02446
(show subtarget assignments)

1

in_crystallization_trials

No

lmo0287

16802333

hypothetical protein lmo0287 [Listeria m...

237

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2OQR

48.1%

Listeria monocytogenes

DNA metabolism

DNA replication, recombination, and repair

IDP05488
(show subtarget assignments)

1

cloned

No

BA_4789

30259275

putative LPXTG-motif cell wall anchor do...

237

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2K78

22.8%

Bacillus anthracis

Unknown function: General

IDP05421
(show subtarget assignments)

1

soluble

No

BAS1418

49184435

-

hypothetical protein BAS1418 [Bacillus a...

237

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05427
(show subtarget assignments)

1

cloned

No

lmo0585

16802628

-

putative secreted protein [Listeria mono...

237

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Hypothetical proteins: Conserved

IDP04362
(show subtarget assignments)

1

soluble

No

YPO3059

218930104

purC

phosphoribosylaminoimidazole-succinocarb...

237

conserved gene; putative drug target function;

Phase 4: April 2009

2GQR

86.9%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Purine ribonucleotide biosynthesis

IDP91666
(show subtarget assignments)

8

selected

No

NS1_I68A0

0

237

virulence/pathogenesis / Selected from a set of pathogenic interactions taken from IRefIndex

Community Requests

3F5T

77.2%

Influenza A

IDP91437
(show subtarget assignments)

8

soluble

No

VV1_0483

27363947

hypothetical protein VV1_0483 [Vibrio vu...

238

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

1U05

49.4%

Vibrio vulnificus

IDP91977
(show subtarget assignments)

8

selected

No

SpneCM_010100007810

298255490

D-alanyl-D-alanine carboxypeptidase [Str...

238

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

Streptococcus pneumoniae

IDP91841
(show subtarget assignments)

8

selected

No

stu0182

55820280

MutR family transcriptional regulator [S...

238

virulence/pathogenesis / Rgg proteins are peptide-ligand-responsive transcription factors that control vi...

Community Requests

Streptococcus thermophilus

IDP04421
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4022

47529315

pyrF

orotidine 5'-phosphate decarboxylase [Ba...

238

putative drug target function;

Phase 4: April 2009

1DBT

61.3%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides

Pyrimidine ribonucleotide biosynthesis

IDP02103
(show subtarget assignments)

1

expressed

No

YPO0891

16121196

dsbC

thiol:disulfide interchange protein DsbC...

238

Drug target motif; Conserved; Proteomics evidence (Cytoplasmid or periplasmic); ...

Phase 3: June 2008

1JZD

61.8%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP00809
(show subtarget assignments)

1

cloned

No

SACOL1869

57284790

splA

serine protease SplA

238

Drug Target Function

Phase 2: March 2008

2W7S

84%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00791
(show subtarget assignments)

1

selected

No

SACOL1178

57284463

superantigen-like protein

238

Virulence Associated Factor

Phase 2: March 2008

1M4V

23.9%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP01468
(show subtarget assignments)

1

purified

No

VC2553

15642548

ABC transporter, ATP-binding protein, au...

238

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

32.8%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP91057
(show subtarget assignments)

8

cloned

No

USA300HOU_2035

161510252

agrA

accessory gene regulator protein A [Stap...

238

virulence/pathogenesis / The target is a drug target for anti-virulence therapy in infections of Methicil...

Community Requests

3BS1

42.9%

Staphylococcus aureus

IDP02557
(show subtarget assignments)

1

purified

No

Cj0061c

15791453

fliA

flagellar biosynthesis sigma factor [Cam...

238

Known Predicted virulence-flagella; PMID:8478066

Phase 3: June 2008

1RP3

35.3%

Campylobacter jejuni

Cellular processes

Chemotaxis and motility

IDP90416
(show subtarget assignments)

8

in_crystallization_trials

No

CT_538

3328976

hypothetical protein [Chlamydia trachoma...

238

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP05628
(show subtarget assignments)

1

soluble

No

CD1444

126699048

putative exported polysaccharide deacety...

239

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2C1G

32.6%

Clostridium difficile

Unknown function: General

IDP91272
(show subtarget assignments)

8

cloned

No

NT05BA3926

49180681

RNA polymerase sigma-29 factor [Bacillus...

239

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1L0O

31.4%

Bacillus anthracis

IDP01917
(show subtarget assignments)

1

soluble

No

GBAA1429

47526701

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

239

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1VZW

36.5%

Bacillus anthracis

Amino acid biosynthesis

Histidine family

IDP01625
(show subtarget assignments)

1

expressed

No

FTT1761

56708756

hypothetical protein FTT1761 [Francisell...

239

Drug Target

Phase 3: June 2008

Francisella tularensis

Unknown function

Enzymes of unknown specificity

IDP01505
(show subtarget assignments)

1

expressed

No

VCA1037

15601788

amino acid ABC transporter, ATP-binding ...

239

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

52.5%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP90224
(show subtarget assignments)

8

in_pdb
3I0U

No

CP0010

31983551

OspF

Shigella OspF effector

239

Shigella OspF effector

Community Requests

3I0U

90.8%

Shigella flexneri

IDP02541
(show subtarget assignments)

1

expressed

No

CBU_1709

29542267

dapB

dihydrodipicolinate reductase [Coxiella ...

239

Conserved; Drug target functions

Phase 3: June 2008

1YL5

42.3%

Coxiella burnetii

Amino acid biosynthesis

Aspartate family

IDP00641
(show subtarget assignments)

1

purified

No

SACOL1866

57284787

serine protease SplD, putative

239

Drug Target Function

Phase 2: March 2008

2VID

43.5%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP00638
(show subtarget assignments)

1

purified

No

SACOL2736

57285290

gidB

glucose-inhibited division protein B

239

Drug Target Function

Phase 2: March 2008

1XDZ

63.2%

Staphylococcus aureus

Unknown function

General

IDP00066
(show subtarget assignments)

1

expressed

No

NTL01CJ00766

6968259

kdsB

3-deoxy-manno-octulosonate cytidylyltran...

239

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2Y6P

40.2%

Campylobacter jejuni

Protein synthesis

tRNA aminoacylation

IDP90134
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_166

68449240

Toll/IL1-receptor [TIR]-like protein [Mo...

240

similar to VACV-COP-A46R, MPXV-ZAI96-A47R

Community Requests

Monkeypox virus

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02278
(show subtarget assignments)

1

expressed

No

Cj0045c

15791444

putative iron-binding protein [Campyloba...

240

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2AWC

13.7%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP00939
(show subtarget assignments)

1

expressed

No

STM0828

16764190

glnQ

glutamine ABC transporter ATP-binding pr...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00197
(show subtarget assignments)

1

purified

No

YPO1233

16121519

-

putative prophage repressor protein

240

Similar to Essential SALTY

Phase 1: October 2007

3BDN

46.2%

Yersinia pestis

IDP00093
(show subtarget assignments)

1

expressed

No

NT01SF0510

30040252

ybbF

hypothetical protein S0463

240

Essential

Phase 1: October 2007

Shigella flexneri

Unknown function

General

IDP00808
(show subtarget assignments)

1

cloned

No

SACOL1868

57284789

splB

serine protease SplB

240

Drug Target Function

Phase 2: March 2008

2VID

85%

Staphylococcus aureus

Protein fate

Degradation of proteins, peptides, and glycopeptides

IDP05023
(show subtarget assignments)

1

expressed

No

BAS2353

49185362

-

hemolysin II, C-terminal [Bacillus anthr...

240

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3ANZ

27.9%

Bacillus anthracis

Cellular processes: Pathogenesis

IDP90900
(show subtarget assignments)

8

cloned

No

YPO3075

16123252

UDP-2,3-diacylglucosamine hydrolase [Yer...

240

Predicted Essential

Community Requests

Yersinia pestis

IDP02578
(show subtarget assignments)

1

expressed

No

STM0262

16763645

yafS

putative SAM-dependent methyltransferase...

240

Conserved; Drug target functions

Phase 3: June 2008

1VLM

11.7%

Salmonella enterica

Unknown function

General

IDP02254
(show subtarget assignments)

1

cloned

No

FTT0766

56707880

deoD

purine nucleoside phosphorylase [Francis...

240

Drug Target

Phase 3: June 2008

1VHJ

43.3%

Francisella tularensis

Purines, pyrimidines, nucleosides, and nucleotides

Salvage of nucleosides and nucleotides

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01143
(show subtarget assignments)

1

in_pdb
3R8Y

No

BA_4194

30258698

2,3,4,5-tetrahydropyridine-2-carboxylate...

240

Drug Target Function

Phase 2: March 2008

3R8Y

100%

Bacillus anthracis

Amino acid biosynthesis

Aspartate family

IDP91435
(show subtarget assignments)

8

cloned

No

VV1_0485

27363949

DNA uptake lipoprotein [Vibrio vulnificu...

241

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3TGO

48.5%

Vibrio vulnificus

IDP00561
(show subtarget assignments)

0

work_stopped

No

YPO1046

16121346

pyrH

uridylate kinase

241

Conserved Gene / Pathway

Phase 2: March 2008

2BNE

90.5%

Yersinia pestis

Purines, pyrimidines, nucleosides, and nucleotides

Nucleotide and nucleoside interconversions

IDP02301
(show subtarget assignments)

1

cloned

No

FTT1249

56708311

cell entry (mce) related family protein ...

241

Drug Target

Phase 3: June 2008

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP02002
(show subtarget assignments)

1

in_pdb
4E4Y

No

FTT1014c

56708103

short chain dehydrogenase family protein...

241

Drug Target

Phase 3: June 2008

4E4Y

100%

Francisella tularensis

Unclassified

Role category not yet assigned

IDP00933
(show subtarget assignments)

1

purified

No

STM0662

16764039

gltL

glutamate/aspartate transporter

241

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01465
(show subtarget assignments)

1

purified

No

VC2528

15642523

ABC transporter, ATP-binding protein

241

Conserved Gene / Pathway

Phase 2: March 2008

1JI0

33.6%

Vibrio cholerae

Transport and binding proteins

Unknown substrate

IDP00068
(show subtarget assignments)

0

work_stopped

No

NT01ST0271

16418722

pyrH

uridylate kinase

241

Essential

Phase 1: October 2007

2BNE

97.9%

Salmonella enterica

Amino acid biosynthesis

Glutamate family

IDP00282
(show subtarget assignments)

1

cloned

No

AAX48017_2243-2483

61652905

N/A

NS4B

241

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP00279
(show subtarget assignments)

1

selected

No

AAA99437_2243-2483

323469

N/A

NS4B

241

possibly RNA replication

Phase 3: June 2008

Dengue virus

Transcription

N/A

IDP04483
(show subtarget assignments)

1

expressed

No

YPO3361

115348990

b2747

4-diphosphocytidyl-2C-methyl-D-erythrito...

241

conserved gene; putative drug target function;

Phase 4: April 2009

1VGT

63.5%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Other

IDP90108
(show subtarget assignments)

8

soluble

No

MPXV_ZAI1979_005_013

68449087

bifunctional zinc finger-like protein/E3...

242

similar to VARV BEN68-zinc finger-like protein

Community Requests

2ECW

8.3%

Monkeypox virus

IDP91772
(show subtarget assignments)

8

expressed

No

AAR87481

40548828

sul3

dihydropteroate synthase [Escherichia co...

242

drug resistance / Dihydropteroate synthase (sulfonamide resistance)

Community Requests

1TWS

36.4%

Escherichia coli

IDP00944
(show subtarget assignments)

1

crystallized

No

STM0891

16764252

artP

arginine transporter ATP-binding subunit...

242

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

43.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01829
(show subtarget assignments)

1

cloned

No

lmo0051

16802099

hypothetical protein lmo0051 [Listeria m...

242

Known virulence-Regulation; PMID:17675424

Phase 3: June 2008

3BS1

15.7%

Listeria monocytogenes

Regulatory functions

Other

IDP05652
(show subtarget assignments)

1

cloned

No

lmo0129

16802177

-

hypothetical protein lmo0129 [Listeria m...

246

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3NE8

27.2%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91154
(show subtarget assignments)

8

in_pdb
3QFG

Yes

SAOUHSC_00808

88194568

hypothetical protein SAOUHSC_00808 [Stap...

242

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3QFG

93.4%

Staphylococcus aureus

IDP90176
(show subtarget assignments)

8

expressed

No

AAM13470.1

20153009

CPXV023 CDS

CPXV023 protein

242

zinc-finger-like protein

Community Requests

2ECW

8.3%

Cowpox virus

host defense modulator

0

IDP02370
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA1958

47527254

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

242

Conserved; Essential; Involved in sporulation;

Phase 3: June 2008

3OEC

40.9%

Bacillus anthracis

Unknown function

Enzymes of unknown specificity

IDP04687
(show subtarget assignments)

1

in_crystallization_trials

No

GBAA4340

47529637

bioD

dithiobiotin synthetase [Bacillus anthra...

242

putative drug target function;

Phase 4: April 2009

1A82

26.9%

Bacillus anthracis

Biosynthesis of cofactors, prosthetic groups, and carriers

Biotin

IDP90360
(show subtarget assignments)

8

in_crystallization_trials

No

CT_016

3328405

hypothetical protein [Chlamydia trachoma...

242

These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

Chlamydia trachomatis

IDP00646
(show subtarget assignments)

1

selected

No

SACOL0887

57284346

sei

staphylococcal enterotoxin type I

242

Virulence Associated Factor

Phase 2: March 2008

2G9H

55%

Staphylococcus aureus

Cellular processes

Toxin production and resistance

IDP02474
(show subtarget assignments)

1

cloned

No

Cj0922c

15792251

pebC

amino acid ABC transporter ATP-binding p...

242

Predicted virulence-Adhesion of Campylobacter

Phase 3: June 2008

2OLJ

52.5%

Campylobacter jejuni

Hypothetical proteins

Conserved

IDP02438
(show subtarget assignments)

1

cloned

No

CBU_0029

29540654

acyltransferase family protein [Coxiella...

242

Conserved; Drug target functions

Phase 3: June 2008

Coxiella burnetii

Unknown function

Enzymes of unknown specificity

IDP90709
(show subtarget assignments)

8

cloned

No

YPO1215

16121506

ubiG

3-demethylubiquinone-9 3-methyltransfera...

242

Predicted Essential

Community Requests

3JWH

20.7%

Yersinia pestis

IDP02112
(show subtarget assignments)

1

cloned

No

FTT1024c

56708113

yhbG

ABC transporter, ATP-binding protein [Fr...

243

Conserved; Drug target functions

Phase 3: June 2008

1JI0

34.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP01012
(show subtarget assignments)

1

purified

No

STM2578

16765898

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Conserved Gene / Pathway

Phase 2: March 2008

1M5W

93.8%

Salmonella enterica

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP91784
(show subtarget assignments)

8

soluble

No

SA1480

15927234

ermA

rRNA methylase Erm(A) [Staphylococcus au...

243

drug resistance / rRNA methylase (macrolide-lincosamide-streptogramin B resistance protein)

Community Requests

1QAM

56.8%

Staphylococcus aureus

IDP00526
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1351

16121631

artI

arginine-binding periplasmic protein 1 p...

243

Conserved Gene / Pathway

Phase 2: March 2008

2Y7I

52.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP91473
(show subtarget assignments)

8

expressed

No

VPA1342

28901197

type III secretion system protein [Vibri...

243

virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio parahaemolyticus

IDP01901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0890

16764251

artI

arginine transport system [Salmonella ty...

243

Conserved; Drug target functions

Phase 3: June 2008

2Y7I

51.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP04210
(show subtarget assignments)

1

expressed

No

ZZZ_0017

243

Effector protein

Phase 4: April 2009

2KXC

18.5%

Escherichia coli

IDP02154
(show subtarget assignments)

1

expressed

No

GBAA2526

47527815

D-alanyl-D-alanine carboxypeptidase fami...

243

Drug target motif; Drug target functions

Phase 3: June 2008

Bacillus anthracis

Cell envelope

Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP90547
(show subtarget assignments)

8

crystallized

No

Cj1601

15792906

hisA

1-(5-phosphoribosyl)-5-[(5-phosphoribosy...

243

Predicted Essential

Community Requests

2X30

33.7%

Campylobacter jejuni

IDP00439
(show subtarget assignments)

1

in_pdb
3F4N

No

YPO2930

16123117

pdxJ

pyridoxal phosphate biosynthetic protein...

243

Virulence Associated Factor

Phase 2: March 2008

3F4N

100%

Yersinia pestis

Biosynthesis of cofactors, prosthetic groups, and carriers

Pyridoxine

IDP04714
(show subtarget assignments)

1

expressed

No

YPO0672

218927865

parF

putative acyltransferase [Yersinia pesti...

243

conserved gene; putative drug target function;

Phase 4: April 2009

Yersinia pestis

Fatty acid and phospholipid metabolism

Biosynthesis

IDP01503
(show subtarget assignments)

1

soluble

No

VCA0978

15601731

amino acid ABC transporter, periplasmic ...

243

Conserved Gene / Pathway

Phase 2: March 2008

1HPB

26.3%

Vibrio cholerae

Transport and binding proteins

Amino acids, peptides and amines

IDP91235
(show subtarget assignments)

8

soluble

No

NT04EC1225

26107466

3-oxoacyl-[acyl-carrier protein] reducta...

243

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

4DML

44.4%

Escherichia coli

Fatty acid and phospholipid metabolism: Biosynthesis

IDP00696
(show subtarget assignments)

1

in_crystallization_trials

No

SACOL2410

57285141

amino acid ABC transporter, ATP-binding ...

243

Drug Target Function

Phase 2: March 2008

2OLJ

52.3%

Staphylococcus aureus

Transport and binding proteins

Amino acids, peptides and amines

IDP02064
(show subtarget assignments)

1

cloned

No

YPO3878

16124011

putative fimbrial chaperone [Yersinia pe...

243

CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions

Phase 3: June 2008

3Q48

32.5%

Yersinia pestis

Protein fate

Protein folding and stabilization

IDP91589
(show subtarget assignments)

8

expressed

No

BAB41266

13699967

ermA

rRNA methylase [Staphylococcus aureus su...

243

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1QAM

56.8%

Staphylococcus aureus

IDP90553
(show subtarget assignments)

8

soluble

No

VC2458

15642454

pyridoxal phosphate biosynthetic protein...

243

Predicted Essential

Community Requests

1M5W

70.8%

Vibrio cholerae

IDP01147
(show subtarget assignments)

1

expressed

No

BA_0639

30254242

amino acid ABC transporter, ATP-binding ...

243

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

60.5%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP00064
(show subtarget assignments)

1

cloned

No

BA_5200

30259683

transcriptional activator tipA, putative...

243

Virulence

Phase 1: October 2007

3QAO

56.2%

Bacillus anthracis

Cellular processes

Toxin production and resistance

IDP05054
(show subtarget assignments)

1

cloned

No

CD0250

126697821

fliH

flagellar assembly protein [Clostridium ...

243

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP00546
(show subtarget assignments)

1

expressed

No

YPO0359

16120694

frdB

fumarate reductase iron-sulfur subunit

244

Virulence Associated Factor

Phase 2: March 2008

1KF6

84.8%

Yersinia pestis

Energy metabolism

Anaerobic

IDP05739
(show subtarget assignments)

1

cloned

No

CD2136

126699752

uppS

undecaprenyl pyrophosphate synthetase [C...

244

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1F75

52.9%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP90545
(show subtarget assignments)

8

soluble

No

YPO1599

16121867

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

244

Predicted Essential

Community Requests

1I01

86.9%

Yersinia pestis

IDP91030
(show subtarget assignments)

8

cloned

No

y3978

22127848

hypothetical protein y3978 [Yersinia pes...

244

other biological interest / Found by experiment to have a DNA binding function - an unknown DNA binding prot...

Community Requests

Yersinia pestis

IDP02511
(show subtarget assignments)

1

soluble

No

CBU_1359

29541924

sufC

ABC transporter, ATP-binding protein [Co...

244

Conserved; Drug target functions

Phase 3: June 2008

2D3W

63.1%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04606
(show subtarget assignments)

1

cloned

No

BAS3692

49186691

tRNA (guanine-N(1)-)-methyltransferase [...

244

Proposed to be essential proteins

Phase 4: April 2009

3KY7

62.3%

Bacillus anthracis

IDP91290
(show subtarget assignments)

8

soluble

No

SPA1656

56413819

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

244

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I01

95.9%

Salmonella enterica

IDP91455
(show subtarget assignments)

8

cloned

No

VV1_0198

27363680

major facilitator superfamily permease [...

244

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP91297
(show subtarget assignments)

8

cloned

No

STM1195

16764550

fabG

3-ketoacyl-(acyl-carrier-protein) reduct...

244

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1I01

95.9%

Salmonella enterica

IDP02135
(show subtarget assignments)

1

in_pdb
3S81
3S7Z

Yes

STM4510

16767754

putative aspartate racemase [Salmonella ...

244

Conserved; Drug target functions

Phase 3: June 2008

3S7Z

100%

Salmonella enterica

Unknown function

General