Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05561 (show subtarget assignments)	1	cloned	No	lmo2026	16804065	-	peptidoglycan binding protein [Listeria ...	626	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1M0Z	11%	Listeria monocytogenes	Transport and binding proteins: Amino acids, peptides and amines

IDP05525 (show subtarget assignments)	1	soluble	No	CD2550	126700167		putative sugar transporter, substrate-bi...	430	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1EU8	25.8%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP01130 (show subtarget assignments)	1	soluble	No	BA_5327	30259803		iron compound ABC transporter, ATP-bindi...	250	Conserved Gene / Pathway	Phase 2: March 2008	2D62	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01129 (show subtarget assignments)	1	in_crystallization_trials	No	BA_5296	30259774		ferritin	168	Conserved Gene / Pathway	Phase 2: March 2008	2JD6	48.2%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01128 (show subtarget assignments)	1	expressed	No	BA_4595	30259095		iron compound ABC transporter, ATP-bindi...	272	Conserved Gene / Pathway	Phase 2: March 2008	2IT1	29.8%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01127 (show subtarget assignments)	1	expressed	No	BA_0618	30254221		iron compound ABC transporter, ATP-bindi...	273	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	29.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01126 (show subtarget assignments)	1	cloned	No	BA_5392	47115756		HPr kinase/phosphorylase (HPrK/P) (HPr(S...	309	Conserved Gene / Pathway	Phase 2: March 2008	1KO7	59.2%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01125 (show subtarget assignments)	1	expressed	No	BA_5175	30259658		ABC transporter, ATP-binding protein	219	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	32.9%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00587 (show subtarget assignments)	1	cloned	No	YPO1507	16121780	mglB	galactose-binding protein	335	Virulence Associated Factor	Phase 2: March 2008	1GCA	80.9%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00127 (show subtarget assignments)	1	soluble	No	NT01ST1705	16764721	sufC	cysteine desulfurase ATPase component	248	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2D3W	92.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP01123 (show subtarget assignments)	1	in_crystallization_trials	No	BA_4267	30258769	ptsI	phosphoenolpyruvate-protein phosphotrans...	570	Conserved Gene / Pathway	Phase 2: March 2008	2HRO	65.4%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01121 (show subtarget assignments)	1	expressed	No	BA_1933	30256591		branched-chain amino acid ABC transporte...	257	Conserved Gene / Pathway	Phase 2: March 2008	1G6H	31.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01120 (show subtarget assignments)	1	in_crystallization_trials	No	BA_1194	30254907		oligopeptide ABC transporter, ATP-bindin...	347	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	27.1%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP02803 (show subtarget assignments)	1	in_crystallization_trials	No	lmo1960	16803999	fhuC	hypothetical protein lmo1960 [Listeria m...	274	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1B0U	28.5%	Listeria monocytogenes	Transport and binding proteins	Cations and iron carrying compounds

IDP01113 (show subtarget assignments)	1	expressed	No	BA_0368	30253903		amino acid ABC transporter, ATP-binding ...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	65.4%	Bacillus anthracis	Transport and binding proteins	Amino acids, peptides and amines

IDP01108 (show subtarget assignments)	1	in_pdb	No	BA_3860	30258377		copper-ion-binding protein	68	Conserved Gene / Pathway	Phase 2: March 2008	2L3M	100%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01104 (show subtarget assignments)	1	soluble	No	BA_4191	30258695		potassium uptake protein, TrkA family	221	Conserved Gene / Pathway	Phase 2: March 2008	2HMS	40.3%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01100 (show subtarget assignments)	1	in_pdb 3K1S	No	BA_5442	30259910	celC-2	PTS system, cellobiose-specific IIA comp...	107	Conserved Gene / Pathway	Phase 2: March 2008	3K1S	99.1%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02058 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0075	16120426	cpxP	periplasmic stress adaptor protein CpxP ...	162	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3ITF	41.4%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00566 (show subtarget assignments)	1	purified	No	YPO0279	16120618	hmuV	hemin transport system ATP-binding prote...	266	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	30.5%	Yersinia pestis	Transport and binding proteins	Other

IDP00565 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0281	16120620	hmuT	hemin-binding periplasmic protein	279	Conserved Gene / Pathway	Phase 2: March 2008	3MD9	91%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00563 (show subtarget assignments)	1	purified	No	YPO0283	16120622	hmuR	hemin receptor precursor	676	Conserved Gene / Pathway	Phase 2: March 2008	3FHH	66.3%	Yersinia pestis	Transport and binding proteins	Other

IDP01067 (show subtarget assignments)	1	expressed	No	STM3854	16767138	pstB	phosphate transporter subunit	257	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	36.2%	Salmonella enterica	Transport and binding proteins	Anions

IDP02797 (show subtarget assignments)	1	cloned	No	lmo2184	16804223		hypothetical protein lmo2184 [Listeria m...	290	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	2Q8P	47.2%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP01060 (show subtarget assignments)	1	crystallized	No	STM3561	16766847	livG	leucine/isoleucine/valine transporter AT...	255	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	31.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02056 (show subtarget assignments)	1	expressed	No	CBU_0934	29541521		ABC transporter, ATP-binding protein [Co...	304	Conserved; Drug target functions	Phase 3: June 2008	1VPL	27.6%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP01052 (show subtarget assignments)	1	expressed	No	STM3324	16766619	ptsO	phosphohistidinoprotein-hexose phosphotr...	90	Conserved Gene / Pathway	Phase 2: March 2008	1JEM	34.4%	Salmonella enterica	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00552 (show subtarget assignments)	1	soluble	No	YPO0282	16120621	hmuS	hemin transport protein	345	Conserved Gene / Pathway	Phase 2: March 2008	2J0R	89.6%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP02778 (show subtarget assignments)	1	cloned	No	CBU_0056	29540679		outer membrane protein TolC, putative [C...	616	Conserved; Drug target functions	Phase 3: June 2008	2VDD	27.4%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP02155 (show subtarget assignments)	1	in_crystallization_trials	No	YPO0239	16120577	trkA	potassium transporter peripheral membran...	458	Conserved; CD; Drug target functions	Phase 3: June 2008	1LSS	12.2%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00118 (show subtarget assignments)	1	in_pdb 3MGA	No	NT01ST0713	16763963	fes	enterobactin/ferric enterobactin esteras...	404	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	3MGA	100%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP04427 (show subtarget assignments)	1	expressed	No	GBAA4784	47530081		iron compound ABC transporter, ATP-bindi...	256	virulence factor; putative drug target function;	Phase 4: April 2009	1F3O	32.4%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP01033 (show subtarget assignments)	1	soluble	No	STM3815	16767100	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02762 (show subtarget assignments)	1	cloned	No	GBAA2482	47527772		ABC transporter ATP-binding protein [Bac...	256	Conserved; Drug target functions	Phase 3: June 2008	1F3O	40.6%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP02305 (show subtarget assignments)	1	purified	No	YPO1310	16121592		putative periplasmic substrate-binding t...	381	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008			Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00232 (show subtarget assignments)	1	cloned	No	YPO3480	16123626	-	conserved hypothetical protein	292	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP01018 (show subtarget assignments)	1	expressed	No	STM2894	16766200	invC	ATP synthase SpaL	431	Conserved Gene / Pathway	Phase 2: March 2008	2OBL	38.7%	Salmonella enterica	Transport and binding proteins	Other

IDP00231 (show subtarget assignments)	1	soluble	No	YPO3479	16123625	-	putative protease	331	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00536 (show subtarget assignments)	1	purified	No	YPO4003	16124128	dppA	periplasmic dipeptide transport protein ...	535	Virulence Associated Factor	Phase 2: March 2008	1DPP	81.5%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02756 (show subtarget assignments)	1	expressed	No	CBU_2038	29542591		ABC transporter, ATP-binding protein [Co...	240	Conserved; Drug target functions	Phase 3: June 2008	2HYD	33.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04408 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_1426	110798602		iron(III) ABC transporter, iron(III)-bin...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3GFV	24.1%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP00526 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1351	16121631	artI	arginine-binding periplasmic protein 1 p...	243	Conserved Gene / Pathway	Phase 2: March 2008	2Y7I	52.7%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP00993 (show subtarget assignments)	0	work_stopped	No	STM2250	16765578	ccmE	cytochrome c-type biogenesis protein Ccm...	159	Conserved Gene / Pathway	Phase 2: March 2008	1SR3	68.6%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02015 (show subtarget assignments)	1	expressed	No	CBU_0107	29540727		ABC transporter, ATP-binding protein [Co...	351	Conserved; Drug target functions	Phase 3: June 2008	3DHW	49.3%	Coxiella burnetii	Transport and binding proteins	Unknown substrate

IDP04389 (show subtarget assignments)	1	in_crystallization_trials	No	CPF_0617	110799796	pstS	phosphate ABC transporter, phosphate-bin...	276	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	32.6%	Clostridium perfringens	Transport and binding proteins	Anions

IDP00988 (show subtarget assignments)	1	expressed	No	STM2163	16765493	yehX	putative ABC-type proline/glycine betain...	315	Conserved Gene / Pathway	Phase 2: March 2008	1V43	32.4%	Salmonella enterica	Transport and binding proteins	Other

IDP04390 (show subtarget assignments)	1	cloned	No	CPF_0618	110799563	pstS	phosphate ABC transporter, phosphate-bin...	272	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1TWY	36.4%	Clostridium perfringens	Transport and binding proteins	Anions

IDP02142 (show subtarget assignments)	1	cloned	No	CBU_0754	29541354		efflux transporter, RND family, MFP subu...	348	Conserved; Drug target functions	Phase 3: June 2008	1VF7	24.7%	Coxiella burnetii	Transport and binding proteins	Other

IDP00978 (show subtarget assignments)	1	purified	No	STM1951	16765289	yecC	putative amino-acid ABC transporter ATP-...	250	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02726 (show subtarget assignments)	1	cloned	No	GBAA4229	47529522		maltosaccharide ABC transporter, maltosa...	419	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	2ZYK	41.5%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00977 (show subtarget assignments)	1	expressed	No	STM1932	16765273	ftnB	ferritin-like protein	167	Conserved Gene / Pathway	Phase 2: March 2008	1EUM	33.5%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP04377 (show subtarget assignments)	1	soluble	No	CPF_2652	110798678		putative maltose/maltodextrin ABC transp...	408	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1URG	38.7%	Clostridium perfringens	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00516 (show subtarget assignments)	1	purified	No	YPO4022	16124145		putative iron transport protein	317	Conserved Gene / Pathway	Phase 2: March 2008	3GFV	34.4%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00972 (show subtarget assignments)	1	expressed	No	STM1743	16765087	oppD	oligopeptide transporter ATP-binding com...	335	Conserved Gene / Pathway	Phase 2: March 2008	1Z47	25.7%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00220 (show subtarget assignments)	1	purified	No	YPO2855	16123048	-	putative protease	464	Virulence	Phase 1: October 2007			Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01971 (show subtarget assignments)	1	soluble	No	STM3065	16766366	yggE	hypothetical protein STM3065 [Salmonella...	248	Conserved; Drug target functions	Phase 3: June 2008			Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP04370 (show subtarget assignments)	1	cloned	No	GBAA4766	47530065		iron compound ABC transporter, iron comp...	324	virulence factor; putative drug target function;	Phase 4: April 2009	3EIW	29.6%	Bacillus anthracis	Transport and binding proteins	Cations and iron carrying compounds

IDP04378 (show subtarget assignments)	1	cloned	No	CPF_2335	110799804		extracellular solute-binding protein [Cl...	482	drug target; conserved gene; putative drug target function;	Phase 4: April 2009			Clostridium perfringens	Transport and binding proteins	Unknown substrate

IDP01968 (show subtarget assignments)	1	purified	No	STM1954	16765292	fliY	cystine transporter subunit [Salmonella ...	266	Conserved; Drug target functions	Phase 3: June 2008	2YLN	35%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01964 (show subtarget assignments)	1	in_pdb 3KWO	No	Cj1534c	15792842		bacterioferritin [Campylobacter jejuni s...	149	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	3KWO	100%	Campylobacter jejuni	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01961 (show subtarget assignments)	1	soluble	No	STM1692	16765035	sapA	peptide transport protein [Salmonella ty...	549	Conserved; Drug target functions	Phase 3: June 2008	1DPP	34.1%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01959 (show subtarget assignments)	1	soluble	No	STM1679	16765022	mppA	periplasmic murein tripeptide transport ...	537	Conserved; Drug target functions	Phase 3: June 2008	3O9P	89.2%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00509 (show subtarget assignments)	1	in_pdb 3RY3	No	YPO2660	16122866		putative solute-binding protein	525	Conserved Gene / Pathway	Phase 2: March 2008	3RY3	100%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01947 (show subtarget assignments)	1	soluble	No	STM1656	16765000	zntB	zinc transporter [Salmonella typhimurium...	327	Conserved; Drug target functions	Phase 3: June 2008	3NVO	80.1%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00958 (show subtarget assignments)	1	soluble	No	STM1218	16764573	lolD	lipoprotein transporter ATP-binding subu...	233	Conserved Gene / Pathway	Phase 2: March 2008	2PCJ	43.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP00505 (show subtarget assignments)	1	in_crystallization_trials	No	YPO1298	16121580	fruB	fructose-specific PTS IIA/HPr components...	377	Conserved Gene / Pathway	Phase 2: March 2008	1A3A	17%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP04563 (show subtarget assignments)	1	soluble	No	CPF_1296	110798598		iron chelate ABC transporter solute-bind...	305	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2CHU	27.9%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP02276 (show subtarget assignments)	1	expressed	No	YPO0860	16121168		sugar-binding periplasmic protein [Yersi...	333	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2IOY	26.7%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00944 (show subtarget assignments)	1	crystallized	No	STM0891	16764252	artP	arginine transporter ATP-binding subunit...	242	Conserved Gene / Pathway	Phase 2: March 2008	1B0U	43.8%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP01910 (show subtarget assignments)	1	expressed	No	CBU_0798	29541392		multidrug resistance protein [Coxiella b...	331	Conserved; Drug target functions	Phase 3: June 2008	3FPP	19.3%	Coxiella burnetii	Transport and binding proteins	Other

IDP00939 (show subtarget assignments)	1	expressed	No	STM0828	16764190	glnQ	glutamine ABC transporter ATP-binding pr...	240	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	55%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP04366 (show subtarget assignments)	1	purified	No	CPF_1531	110800274		amino acid ABC transporter, amino acid-b...	262	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	3HV1	36.6%	Clostridium perfringens	Transport and binding proteins	Amino acids, peptides and amines

IDP00104 (show subtarget assignments)	1	purified	No	NT01SF3305	30042319	srlB	PTS system, glucitol/sorbitol-specific e...	123	These targets are similar to actual drug targets and will be used mostly for coc...	Phase 1: October 2007	2F9H	25.2%	Shigella flexneri	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP01901 (show subtarget assignments)	1	in_crystallization_trials	No	STM0890	16764251	artI	arginine transport system [Salmonella ty...	243	Conserved; Drug target functions	Phase 3: June 2008	2Y7I	51.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP00935 (show subtarget assignments)	1	purified	No	STM0783	16764147	modC	molybdate transporter ATP-binding protei...	352	Conserved Gene / Pathway	Phase 2: March 2008	3D31	29.5%	Salmonella enterica	Transport and binding proteins	Anions

IDP00934 (show subtarget assignments)	0	work_stopped	No	STM0779	16764143	modE	DNA-binding transcriptional dual regulat...	262	Conserved Gene / Pathway	Phase 2: March 2008	1B9M	89.3%	Salmonella enterica	Transport and binding proteins	Anions

IDP00933 (show subtarget assignments)	1	purified	No	STM0662	16764039	gltL	glutamate/aspartate transporter	241	Conserved Gene / Pathway	Phase 2: March 2008	2OLJ	54.4%	Salmonella enterica	Transport and binding proteins	Amino acids, peptides and amines

IDP02749 (show subtarget assignments)	1	soluble	No	CBU_0482	29541088		amino acid ABC transporter, periplasmic ...	269	Conserved; Drug target functions	Phase 3: June 2008	3TQL	84.4%	Coxiella burnetii	Transport and binding proteins	Amino acids, peptides and amines

IDP00210 (show subtarget assignments)	1	crystallized	No	YPO0314	16120652	lexA	LexA repressor	202	Virulence	Phase 1: October 2007	1JHF	91.1%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02687 (show subtarget assignments)	1	cloned	No	lmo2580	16804618		hypothetical protein lmo2580 [Listeria m...	222	Predicted virulence-Iron Scavenging Mechanisms	Phase 3: June 2008	1F3O	46.8%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP00208 (show subtarget assignments)	1	expressed	No	YPO1979	16122221	-	putative dehydrogenase	338	Virulence	Phase 1: October 2007	2PK3	21.3%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02259 (show subtarget assignments)	1	cloned	No	GBAA2164	47527458		ABC transporter ATP-binding protein [Bac...	631	Conserved; Drug target functions	Phase 3: June 2008	1YQT	21.4%	Bacillus anthracis	Transport and binding proteins	Unknown substrate

IDP00924 (show subtarget assignments)	1	purified	No	STM0590	16763967	fepC	iron-enterobactin transporter ATP-bindin...	264	Conserved Gene / Pathway	Phase 2: March 2008	3GFO	28.4%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP00490 (show subtarget assignments)	1	cloned	No	YPO1537	16121810		putative iron-siderophore receptor	753	Conserved Gene / Pathway	Phase 2: March 2008	3EFM	36%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00489 (show subtarget assignments)	1	purified	No	YPO1533	16121806		putative iron-siderophore transport syst...	282	Conserved Gene / Pathway	Phase 2: March 2008	3FVQ	28.4%	Yersinia pestis	Transport and binding proteins	Cations and iron carrying compounds

IDP00921 (show subtarget assignments)	1	purified	No	STM0507	16763887	ybbA	putative ABC transporter ATP-binding pro...	228	Conserved Gene / Pathway	Phase 2: March 2008	1F3O	42.5%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP04546 (show subtarget assignments)	1	cloned	No	CPF_0213	110799242		putative iron chelate uptake ABC transpo...	295	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	2Q8P	31.2%	Clostridium perfringens	Transport and binding proteins	Cations and iron carrying compounds

IDP00487 (show subtarget assignments)	1	purified	No	YPO1491	16121764		ABC transporter ATP-binding protein	531	Conserved Gene / Pathway	Phase 2: March 2008	3BK7	24.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP00917 (show subtarget assignments)	1	cloned	No	STM0355	16763735		putative copper chaperone	64	Conserved Gene / Pathway	Phase 2: March 2008	2K2P	39.1%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP02684 (show subtarget assignments)	1	cloned	No	FTT0405	56707554	lolD	lipoprotein releasing system, subunit D,...	231	Conserved; Drug target functions	Phase 3: June 2008	1F3O	44.6%	Francisella tularensis	Transport and binding proteins	Unknown substrate

IDP00916 (show subtarget assignments)	0	work_stopped	No	STM0247	16763636	metN	DL-methionine transporter ATP-binding su...	343	Conserved Gene / Pathway	Phase 2: March 2008	3DHW	95.3%	Salmonella enterica	Transport and binding proteins	Unknown substrate

IDP01862 (show subtarget assignments)	1	soluble	No	GBAA5510	47530828	tagH	teichoic acids export protein ATP-bindin...	549	Conserved; Involved in sporulation; Drug target functions	Phase 3: June 2008	1F3O	12.4%	Bacillus anthracis	Transport and binding proteins	Other

IDP00206 (show subtarget assignments)	1	soluble	No	YPO1706	16121966	-	putative heat shock protein	293	Virulence	Phase 1: October 2007	3CQB	28.7%	Yersinia pestis	Transport and binding proteins	Unknown substrate

IDP01859 (show subtarget assignments)	1	cloned	No	lmo2558	16804596	ami	autolysin, amidase [Listeria monocytogen...	917	Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838	Phase 3: June 2008	1M9S	14.7%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP00912 (show subtarget assignments)	1	soluble	No	STM0193	16763583	fhuD	iron-hydroxamate transporter substrate-b...	296	Conserved Gene / Pathway	Phase 2: March 2008	1ESZ	75%	Salmonella enterica	Transport and binding proteins	Cations and iron carrying compounds

IDP01852 (show subtarget assignments)	1	cloned	No	GBAA5449	47530763	celA-3	PTS system, cellobiose-specific IIB comp...	100	Conserved; Essential; Drug target functions	Phase 3: June 2008	1H9C	41%	Bacillus anthracis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP02249 (show subtarget assignments)	1	expressed	No	YPO0955	16121258		hypothetical protein YPO0955 [Yersinia p...	323	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	2R79	22%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP02671 (show subtarget assignments)	1	selected	No	lmo0997	16803037	clpE	ATP-dependent protease [Listeria monocyt...	724	Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs	Phase 3: June 2008	1QVR	46.3%	Listeria monocytogenes	Transport and binding proteins	Unknown substrate

IDP02243 (show subtarget assignments)	1	cloned	No	YPO0834	16121142	manX	putative PTS transport protein [Yersinia...	165	Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...	Phase 3: June 2008	3EYE	41.8%	Yersinia pestis	Transport and binding proteins	Carbohydrates, organic alcohols, and acids

IDP00203 (show subtarget assignments)	1	in_pdb 3T7B	No	YPO3925	16124056	argB	acetylglutamate kinase	257	Virulence	Phase 1: October 2007	3T7B	100%	Yersinia pestis	Transport and binding proteins	Amino acids, peptides and amines

IDP05561
(show subtarget assignments)

1

cloned

No

lmo2026

16804065

-

peptidoglycan binding protein [Listeria ...

626

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1M0Z

11%

Listeria monocytogenes

Transport and binding proteins: Amino acids, peptides and amines

IDP05525
(show subtarget assignments)

1

soluble

No

CD2550

126700167

putative sugar transporter, substrate-bi...

430

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1EU8

25.8%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP01130
(show subtarget assignments)

1

soluble

No

BA_5327

30259803

iron compound ABC transporter, ATP-bindi...

250

Conserved Gene / Pathway

Phase 2: March 2008

2D62

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01129
(show subtarget assignments)

1

in_crystallization_trials

No

BA_5296

30259774

ferritin

168

Conserved Gene / Pathway

Phase 2: March 2008

2JD6

48.2%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01128
(show subtarget assignments)

1

expressed

No

BA_4595

30259095

iron compound ABC transporter, ATP-bindi...

272

Conserved Gene / Pathway

Phase 2: March 2008

2IT1

29.8%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01127
(show subtarget assignments)

1

expressed

No

BA_0618

30254221

iron compound ABC transporter, ATP-bindi...

273

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

29.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01126
(show subtarget assignments)

1

cloned

No

BA_5392

47115756

HPr kinase/phosphorylase (HPrK/P) (HPr(S...

309

Conserved Gene / Pathway

Phase 2: March 2008

1KO7

59.2%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01125
(show subtarget assignments)

1

expressed

No

BA_5175

30259658

ABC transporter, ATP-binding protein

219

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

32.9%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00587
(show subtarget assignments)

1

cloned

No

YPO1507

16121780

mglB

galactose-binding protein

335

Virulence Associated Factor

Phase 2: March 2008

1GCA

80.9%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00127
(show subtarget assignments)

1

soluble

No

NT01ST1705

16764721

sufC

cysteine desulfurase ATPase component

248

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2D3W

92.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP01123
(show subtarget assignments)

1

in_crystallization_trials

No

BA_4267

30258769

ptsI

phosphoenolpyruvate-protein phosphotrans...

570

Conserved Gene / Pathway

Phase 2: March 2008

2HRO

65.4%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01121
(show subtarget assignments)

1

expressed

No

BA_1933

30256591

branched-chain amino acid ABC transporte...

257

Conserved Gene / Pathway

Phase 2: March 2008

1G6H

31.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01120
(show subtarget assignments)

1

in_crystallization_trials

No

BA_1194

30254907

oligopeptide ABC transporter, ATP-bindin...

347

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

27.1%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP02803
(show subtarget assignments)

1

in_crystallization_trials

No

lmo1960

16803999

fhuC

hypothetical protein lmo1960 [Listeria m...

274

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1B0U

28.5%

Listeria monocytogenes

Transport and binding proteins

Cations and iron carrying compounds

IDP01113
(show subtarget assignments)

1

expressed

No

BA_0368

30253903

amino acid ABC transporter, ATP-binding ...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

65.4%

Bacillus anthracis

Transport and binding proteins

Amino acids, peptides and amines

IDP01108
(show subtarget assignments)

1

in_pdb

No

BA_3860

30258377

copper-ion-binding protein

68

Conserved Gene / Pathway

Phase 2: March 2008

2L3M

100%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01104
(show subtarget assignments)

1

soluble

No

BA_4191

30258695

potassium uptake protein, TrkA family

221

Conserved Gene / Pathway

Phase 2: March 2008

2HMS

40.3%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01100
(show subtarget assignments)

1

in_pdb
3K1S

No

BA_5442

30259910

celC-2

PTS system, cellobiose-specific IIA comp...

107

Conserved Gene / Pathway

Phase 2: March 2008

3K1S

99.1%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02058
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0075

16120426

cpxP

periplasmic stress adaptor protein CpxP ...

162

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3ITF

41.4%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00566
(show subtarget assignments)

1

purified

No

YPO0279

16120618

hmuV

hemin transport system ATP-binding prote...

266

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

30.5%

Yersinia pestis

Transport and binding proteins

Other

IDP00565
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0281

16120620

hmuT

hemin-binding periplasmic protein

279

Conserved Gene / Pathway

Phase 2: March 2008

3MD9

91%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00563
(show subtarget assignments)

1

purified

No

YPO0283

16120622

hmuR

hemin receptor precursor

676

Conserved Gene / Pathway

Phase 2: March 2008

3FHH

66.3%

Yersinia pestis

Transport and binding proteins

Other

IDP01067
(show subtarget assignments)

1

expressed

No

STM3854

16767138

pstB

phosphate transporter subunit

257

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

36.2%

Salmonella enterica

Transport and binding proteins

Anions

IDP02797
(show subtarget assignments)

1

cloned

No

lmo2184

16804223

hypothetical protein lmo2184 [Listeria m...

290

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

2Q8P

47.2%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP01060
(show subtarget assignments)

1

crystallized

No

STM3561

16766847

livG

leucine/isoleucine/valine transporter AT...

255

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

31.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02056
(show subtarget assignments)

1

expressed

No

CBU_0934

29541521

ABC transporter, ATP-binding protein [Co...

304

Conserved; Drug target functions

Phase 3: June 2008

1VPL

27.6%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP01052
(show subtarget assignments)

1

expressed

No

STM3324

16766619

ptsO

phosphohistidinoprotein-hexose phosphotr...

90

Conserved Gene / Pathway

Phase 2: March 2008

1JEM

34.4%

Salmonella enterica

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00552
(show subtarget assignments)

1

soluble

No

YPO0282

16120621

hmuS

hemin transport protein

345

Conserved Gene / Pathway

Phase 2: March 2008

2J0R

89.6%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP02778
(show subtarget assignments)

1

cloned

No

CBU_0056

29540679

outer membrane protein TolC, putative [C...

616

Conserved; Drug target functions

Phase 3: June 2008

2VDD

27.4%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP02155
(show subtarget assignments)

1

in_crystallization_trials

No

YPO0239

16120577

trkA

potassium transporter peripheral membran...

458

Conserved; CD; Drug target functions

Phase 3: June 2008

1LSS

12.2%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00118
(show subtarget assignments)

1

in_pdb
3MGA

No

NT01ST0713

16763963

fes

enterobactin/ferric enterobactin esteras...

404

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

3MGA

100%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP04427
(show subtarget assignments)

1

expressed

No

GBAA4784

47530081

iron compound ABC transporter, ATP-bindi...

256

virulence factor; putative drug target function;

Phase 4: April 2009

1F3O

32.4%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP01033
(show subtarget assignments)

1

soluble

No

STM3815

16767100

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02762
(show subtarget assignments)

1

cloned

No

GBAA2482

47527772

ABC transporter ATP-binding protein [Bac...

256

Conserved; Drug target functions

Phase 3: June 2008

1F3O

40.6%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP02305
(show subtarget assignments)

1

purified

No

YPO1310

16121592

putative periplasmic substrate-binding t...

381

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00232
(show subtarget assignments)

1

cloned

No

YPO3480

16123626

-

conserved hypothetical protein

292

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP01018
(show subtarget assignments)

1

expressed

No

STM2894

16766200

invC

ATP synthase SpaL

431

Conserved Gene / Pathway

Phase 2: March 2008

2OBL

38.7%

Salmonella enterica

Transport and binding proteins

Other

IDP00231
(show subtarget assignments)

1

soluble

No

YPO3479

16123625

-

putative protease

331

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00536
(show subtarget assignments)

1

purified

No

YPO4003

16124128

dppA

periplasmic dipeptide transport protein ...

535

Virulence Associated Factor

Phase 2: March 2008

1DPP

81.5%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02756
(show subtarget assignments)

1

expressed

No

CBU_2038

29542591

ABC transporter, ATP-binding protein [Co...

240

Conserved; Drug target functions

Phase 3: June 2008

2HYD

33.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04408
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_1426

110798602

iron(III) ABC transporter, iron(III)-bin...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3GFV

24.1%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP00526
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1351

16121631

artI

arginine-binding periplasmic protein 1 p...

243

Conserved Gene / Pathway

Phase 2: March 2008

2Y7I

52.7%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP00993
(show subtarget assignments)

0

work_stopped

No

STM2250

16765578

ccmE

cytochrome c-type biogenesis protein Ccm...

159

Conserved Gene / Pathway

Phase 2: March 2008

1SR3

68.6%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02015
(show subtarget assignments)

1

expressed

No

CBU_0107

29540727

ABC transporter, ATP-binding protein [Co...

351

Conserved; Drug target functions

Phase 3: June 2008

3DHW

49.3%

Coxiella burnetii

Transport and binding proteins

Unknown substrate

IDP04389
(show subtarget assignments)

1

in_crystallization_trials

No

CPF_0617

110799796

pstS

phosphate ABC transporter, phosphate-bin...

276

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

32.6%

Clostridium perfringens

Transport and binding proteins

Anions

IDP00988
(show subtarget assignments)

1

expressed

No

STM2163

16765493

yehX

putative ABC-type proline/glycine betain...

315

Conserved Gene / Pathway

Phase 2: March 2008

1V43

32.4%

Salmonella enterica

Transport and binding proteins

Other

IDP04390
(show subtarget assignments)

1

cloned

No

CPF_0618

110799563

pstS

phosphate ABC transporter, phosphate-bin...

272

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1TWY

36.4%

Clostridium perfringens

Transport and binding proteins

Anions

IDP02142
(show subtarget assignments)

1

cloned

No

CBU_0754

29541354

efflux transporter, RND family, MFP subu...

348

Conserved; Drug target functions

Phase 3: June 2008

1VF7

24.7%

Coxiella burnetii

Transport and binding proteins

Other

IDP00978
(show subtarget assignments)

1

purified

No

STM1951

16765289

yecC

putative amino-acid ABC transporter ATP-...

250

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02726
(show subtarget assignments)

1

cloned

No

GBAA4229

47529522

maltosaccharide ABC transporter, maltosa...

419

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

2ZYK

41.5%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00977
(show subtarget assignments)

1

expressed

No

STM1932

16765273

ftnB

ferritin-like protein

167

Conserved Gene / Pathway

Phase 2: March 2008

1EUM

33.5%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP04377
(show subtarget assignments)

1

soluble

No

CPF_2652

110798678

putative maltose/maltodextrin ABC transp...

408

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1URG

38.7%

Clostridium perfringens

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00516
(show subtarget assignments)

1

purified

No

YPO4022

16124145

putative iron transport protein

317

Conserved Gene / Pathway

Phase 2: March 2008

3GFV

34.4%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00972
(show subtarget assignments)

1

expressed

No

STM1743

16765087

oppD

oligopeptide transporter ATP-binding com...

335

Conserved Gene / Pathway

Phase 2: March 2008

1Z47

25.7%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00220
(show subtarget assignments)

1

purified

No

YPO2855

16123048

-

putative protease

464

Virulence

Phase 1: October 2007

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01971
(show subtarget assignments)

1

soluble

No

STM3065

16766366

yggE

hypothetical protein STM3065 [Salmonella...

248

Conserved; Drug target functions

Phase 3: June 2008

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP04370
(show subtarget assignments)

1

cloned

No

GBAA4766

47530065

iron compound ABC transporter, iron comp...

324

virulence factor; putative drug target function;

Phase 4: April 2009

3EIW

29.6%

Bacillus anthracis

Transport and binding proteins

Cations and iron carrying compounds

IDP04378
(show subtarget assignments)

1

cloned

No

CPF_2335

110799804

extracellular solute-binding protein [Cl...

482

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

Clostridium perfringens

Transport and binding proteins

Unknown substrate

IDP01968
(show subtarget assignments)

1

purified

No

STM1954

16765292

fliY

cystine transporter subunit [Salmonella ...

266

Conserved; Drug target functions

Phase 3: June 2008

2YLN

35%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01964
(show subtarget assignments)

1

in_pdb
3KWO

No

Cj1534c

15792842

bacterioferritin [Campylobacter jejuni s...

149

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

3KWO

100%

Campylobacter jejuni

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01961
(show subtarget assignments)

1

soluble

No

STM1692

16765035

sapA

peptide transport protein [Salmonella ty...

549

Conserved; Drug target functions

Phase 3: June 2008

1DPP

34.1%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01959
(show subtarget assignments)

1

soluble

No

STM1679

16765022

mppA

periplasmic murein tripeptide transport ...

537

Conserved; Drug target functions

Phase 3: June 2008

3O9P

89.2%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00509
(show subtarget assignments)

1

in_pdb
3RY3

No

YPO2660

16122866

putative solute-binding protein

525

Conserved Gene / Pathway

Phase 2: March 2008

3RY3

100%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01947
(show subtarget assignments)

1

soluble

No

STM1656

16765000

zntB

zinc transporter [Salmonella typhimurium...

327

Conserved; Drug target functions

Phase 3: June 2008

3NVO

80.1%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00958
(show subtarget assignments)

1

soluble

No

STM1218

16764573

lolD

lipoprotein transporter ATP-binding subu...

233

Conserved Gene / Pathway

Phase 2: March 2008

2PCJ

43.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP00505
(show subtarget assignments)

1

in_crystallization_trials

No

YPO1298

16121580

fruB

fructose-specific PTS IIA/HPr components...

377

Conserved Gene / Pathway

Phase 2: March 2008

1A3A

17%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP04563
(show subtarget assignments)

1

soluble

No

CPF_1296

110798598

iron chelate ABC transporter solute-bind...

305

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2CHU

27.9%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP02276
(show subtarget assignments)

1

expressed

No

YPO0860

16121168

sugar-binding periplasmic protein [Yersi...

333

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2IOY

26.7%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00944
(show subtarget assignments)

1

crystallized

No

STM0891

16764252

artP

arginine transporter ATP-binding subunit...

242

Conserved Gene / Pathway

Phase 2: March 2008

1B0U

43.8%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP01910
(show subtarget assignments)

1

expressed

No

CBU_0798

29541392

multidrug resistance protein [Coxiella b...

331

Conserved; Drug target functions

Phase 3: June 2008

3FPP

19.3%

Coxiella burnetii

Transport and binding proteins

Other

IDP00939
(show subtarget assignments)

1

expressed

No

STM0828

16764190

glnQ

glutamine ABC transporter ATP-binding pr...

240

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

55%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP04366
(show subtarget assignments)

1

purified

No

CPF_1531

110800274

amino acid ABC transporter, amino acid-b...

262

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

3HV1

36.6%

Clostridium perfringens

Transport and binding proteins

Amino acids, peptides and amines

IDP00104
(show subtarget assignments)

1

purified

No

NT01SF3305

30042319

srlB

PTS system, glucitol/sorbitol-specific e...

123

These targets are similar to actual drug targets and will be used mostly for coc...

Phase 1: October 2007

2F9H

25.2%

Shigella flexneri

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP01901
(show subtarget assignments)

1

in_crystallization_trials

No

STM0890

16764251

artI

arginine transport system [Salmonella ty...

243

Conserved; Drug target functions

Phase 3: June 2008

2Y7I

51.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP00935
(show subtarget assignments)

1

purified

No

STM0783

16764147

modC

molybdate transporter ATP-binding protei...

352

Conserved Gene / Pathway

Phase 2: March 2008

3D31

29.5%

Salmonella enterica

Transport and binding proteins

Anions

IDP00934
(show subtarget assignments)

0

work_stopped

No

STM0779

16764143

modE

DNA-binding transcriptional dual regulat...

262

Conserved Gene / Pathway

Phase 2: March 2008

1B9M

89.3%

Salmonella enterica

Transport and binding proteins

Anions

IDP00933
(show subtarget assignments)

1

purified

No

STM0662

16764039

gltL

glutamate/aspartate transporter

241

Conserved Gene / Pathway

Phase 2: March 2008

2OLJ

54.4%

Salmonella enterica

Transport and binding proteins

Amino acids, peptides and amines

IDP02749
(show subtarget assignments)

1

soluble

No

CBU_0482

29541088

amino acid ABC transporter, periplasmic ...

269

Conserved; Drug target functions

Phase 3: June 2008

3TQL

84.4%

Coxiella burnetii

Transport and binding proteins

Amino acids, peptides and amines

IDP00210
(show subtarget assignments)

1

crystallized

No

YPO0314

16120652

lexA

LexA repressor

202

Virulence

Phase 1: October 2007

1JHF

91.1%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02687
(show subtarget assignments)

1

cloned

No

lmo2580

16804618

hypothetical protein lmo2580 [Listeria m...

222

Predicted virulence-Iron Scavenging Mechanisms

Phase 3: June 2008

1F3O

46.8%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP00208
(show subtarget assignments)

1

expressed

No

YPO1979

16122221

-

putative dehydrogenase

338

Virulence

Phase 1: October 2007

2PK3

21.3%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02259
(show subtarget assignments)

1

cloned

No

GBAA2164

47527458

ABC transporter ATP-binding protein [Bac...

631

Conserved; Drug target functions

Phase 3: June 2008

1YQT

21.4%

Bacillus anthracis

Transport and binding proteins

Unknown substrate

IDP00924
(show subtarget assignments)

1

purified

No

STM0590

16763967

fepC

iron-enterobactin transporter ATP-bindin...

264

Conserved Gene / Pathway

Phase 2: March 2008

3GFO

28.4%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP00490
(show subtarget assignments)

1

cloned

No

YPO1537

16121810

putative iron-siderophore receptor

753

Conserved Gene / Pathway

Phase 2: March 2008

3EFM

36%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00489
(show subtarget assignments)

1

purified

No

YPO1533

16121806

putative iron-siderophore transport syst...

282

Conserved Gene / Pathway

Phase 2: March 2008

3FVQ

28.4%

Yersinia pestis

Transport and binding proteins

Cations and iron carrying compounds

IDP00921
(show subtarget assignments)

1

purified

No

STM0507

16763887

ybbA

putative ABC transporter ATP-binding pro...

228

Conserved Gene / Pathway

Phase 2: March 2008

1F3O

42.5%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP04546
(show subtarget assignments)

1

cloned

No

CPF_0213

110799242

putative iron chelate uptake ABC transpo...

295

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

2Q8P

31.2%

Clostridium perfringens

Transport and binding proteins

Cations and iron carrying compounds

IDP00487
(show subtarget assignments)

1

purified

No

YPO1491

16121764

ABC transporter ATP-binding protein

531

Conserved Gene / Pathway

Phase 2: March 2008

3BK7

24.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP00917
(show subtarget assignments)

1

cloned

No

STM0355

16763735

putative copper chaperone

64

Conserved Gene / Pathway

Phase 2: March 2008

2K2P

39.1%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP02684
(show subtarget assignments)

1

cloned

No

FTT0405

56707554

lolD

lipoprotein releasing system, subunit D,...

231

Conserved; Drug target functions

Phase 3: June 2008

1F3O

44.6%

Francisella tularensis

Transport and binding proteins

Unknown substrate

IDP00916
(show subtarget assignments)

0

work_stopped

No

STM0247

16763636

metN

DL-methionine transporter ATP-binding su...

343

Conserved Gene / Pathway

Phase 2: March 2008

3DHW

95.3%

Salmonella enterica

Transport and binding proteins

Unknown substrate

IDP01862
(show subtarget assignments)

1

soluble

No

GBAA5510

47530828

tagH

teichoic acids export protein ATP-bindin...

549

Conserved; Involved in sporulation; Drug target functions

Phase 3: June 2008

1F3O

12.4%

Bacillus anthracis

Transport and binding proteins

Other

IDP00206
(show subtarget assignments)

1

soluble

No

YPO1706

16121966

-

putative heat shock protein

293

Virulence

Phase 1: October 2007

3CQB

28.7%

Yersinia pestis

Transport and binding proteins

Unknown substrate

IDP01859
(show subtarget assignments)

1

cloned

No

lmo2558

16804596

ami

autolysin, amidase [Listeria monocytogen...

917

Known virulence-adherence; Possible Vaccine Candidate; PMID:11251838

Phase 3: June 2008

1M9S

14.7%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP00912
(show subtarget assignments)

1

soluble

No

STM0193

16763583

fhuD

iron-hydroxamate transporter substrate-b...

296

Conserved Gene / Pathway

Phase 2: March 2008

1ESZ

75%

Salmonella enterica

Transport and binding proteins

Cations and iron carrying compounds

IDP01852
(show subtarget assignments)

1

cloned

No

GBAA5449

47530763

celA-3

PTS system, cellobiose-specific IIB comp...

100

Conserved; Essential; Drug target functions

Phase 3: June 2008

1H9C

41%

Bacillus anthracis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP02249
(show subtarget assignments)

1

expressed

No

YPO0955

16121258

hypothetical protein YPO0955 [Yersinia p...

323

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

2R79

22%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

IDP02671
(show subtarget assignments)

1

selected

No

lmo0997

16803037

clpE

ATP-dependent protease [Listeria monocyt...

724

Known virulence-Invasion; PMID:9987121; Presence of Protease Motifs

Phase 3: June 2008

1QVR

46.3%

Listeria monocytogenes

Transport and binding proteins

Unknown substrate

IDP02243
(show subtarget assignments)

1

cloned

No

YPO0834

16121142

manX

putative PTS transport protein [Yersinia...

165

Conserved; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functio...

Phase 3: June 2008

3EYE

41.8%

Yersinia pestis

Transport and binding proteins

Carbohydrates, organic alcohols, and acids

IDP00203
(show subtarget assignments)

1

in_pdb
3T7B

No

YPO3925

16124056

argB

acetylglutamate kinase

257

Virulence

Phase 1: October 2007

3T7B

100%

Yersinia pestis

Transport and binding proteins

Amino acids, peptides and amines

Targets