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Targets
Filter Targets:
Selection Phase:
No Filter
Community Interest
Community Requests
January 2009
Phase 1: October 2007
Phase 2: March 2008
Phase 3: June 2008
Phase 4: April 2009
Phase 5: 2010
Tigr Main Category:
No Filter
0
Actin tail formation
Amino acid biosynthesis
Amino acid biosynthesis: Aromatic amino acid family
Amino acid biosynthesis: Aspartate family
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,
Amino acid biosynthesisBiosynthesis of cofactors, prosthetic groups, and carriers,Purines, pyrimidin
Amino acid biosynthesisCell envelope,
Amino acid biosynthesisCentral intermediary metabolism
Amino acid biosynthesisCentral intermediary metabolism,
Amino acid biosynthesisCentral intermediary metabolism,Purines, pyrimidines, nucleosides, and nucleo
Amino acid biosynthesisEnergy metabolism,
Amino acid biosynthesisFatty acid and phospholipid metabolism
Amino acid biosynthesisFatty acid and phospholipid metabolism,
Amino acid biosynthesisRegulatory functions
Amino acid biosynthesisRegulatory functions,
Amino acid biosynthesis: Serine family
Biosynthesis of cofactors, prosthetic groups, and carriers
Biosynthesis of cofactors, prosthetic groups, and carriersCell envelope,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,
Biosynthesis of cofactors, prosthetic groups, and carriersCentral intermediary metabolism,Protein sy
Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs
Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin
Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone
Biosynthesis of cofactors, prosthetic groups, and carriers: Other
Biosynthesis of cofactors, prosthetic groups, and carriersPurines, pyrimidines, nucleosides, and nuc
Biosynthesis of cofactors, prosthetic groups, and carriers: Pyridine nucleotides
Biosynthesis of cofactors, prosthetic groups, and carriersRegulatory functions,
Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD
Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine
Cell envelope
Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan
Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Cell envelopeCellular processes
Cell envelopeCellular processes,
Cell envelopeEnergy metabolism,
Cell envelopeFatty acid and phospholipid metabolism,
Cell envelopeMobile and extrachromosomal element functions
Cell envelopeMobile and extrachromosomal element functions,
Cell envelope: Other
Cell envelopeProtein fate
Cell envelopeProtein fate,
Cell envelopeRegulatory functions,Unknown function
Cell envelopeRegulatory functions,Unknown function,
Cell envelope: Surface structures
Cell envelopeTransport and binding proteins,
Cell envelopeTransport and binding proteins,Cellular processes,
Cell envelopeUnclassified,
Cell envelopeUnknown function
Cell envelopeUnknown function,
Cellular processes
Cellular processes: Adaptations to atypical conditions
Cellular processes: Cell adhesion
Cellular processes: Cell division
Cellular processesCentral intermediary metabolism,Signal transduction,
Cellular processes: Chemotaxis and motility
Cellular processes: Detoxification
Cellular processes: DNA transformation
Cellular processesEnergy metabolism,
Cellular processesEnergy metabolism,Protein fate,
Cellular processes: Other
Cellular processes: Pathogenesis
Cellular processesProtein synthesis
Cellular processesProtein synthesis,
Cellular processesRegulatory functions
Cellular processesRegulatory functions,
Cellular processes: Sporulation and germination
Cellular processes: Toxin production and resistance
Cellular processesTranscription
Cellular processesTranscription,
Cellular processesTransport and binding proteins
Cellular processesTransport and binding proteins,
Central intermediary metabolism
Central intermediary metabolism: Amino sugars
Central intermediary metabolismEnergy metabolism,
Central intermediary metabolismEnergy metabolism,Fatty acid and phospholipid metabolism,
Central intermediary metabolismEnergy metabolism,Unknown function,
Central intermediary metabolism: Nitrogen metabolism
Central intermediary metabolism: Other
Central intermediary metabolismProtein fate,
Central intermediary metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Central intermediary metabolismUnknown function
Central intermediary metabolismUnknown function,
Chr.
conserved hypothetical proteins
Conserved Hypothetical proteins
Disrupted reading frame
DNA metabolism
DNA metabolism: Degradation of DNA
DNA metabolism: DNA replication, recombination, and repair
DNA metabolismMobile and extrachromosomal element functions,
DNA metabolismTranscription,
Energy metabolism
Energy metabolism: ATP-proton motive force interconversion
Energy metabolism: Biosynthesis and degradation of polysaccharides
Energy metabolism: Electron transport
Energy metabolismFatty acid and phospholipid metabolism
Energy metabolismFatty acid and phospholipid metabolism,
Energy metabolism: Fermentation
Energy metabolism: Glycolysis/gluconeogenesis
Energy metabolismPurines, pyrimidines, nucleosides, and nucleotides,
Energy metabolismRegulatory functions,Protein synthesis
Energy metabolismRegulatory functions,Protein synthesis,
Energy metabolism: Sugars
Energy metabolism: TCA cycle
Energy metabolismTransport and binding proteins,
Energy metabolismTransport and binding proteins,Central intermediary metabolism,
Energy metabolismUnknown function,
Entry and Cell-Cell Fusion
Fatty acid and phospholipid metabolism
Fatty acid and phospholipid metabolism: Biosynthesis
Fatty acid and phospholipid metabolism: Degradation
host defense modulator
host-range
host-range, binds EGF receptor
host-range determinant, host defense modulator
host range factor
host range factor, host defense modulator
host range, host defense modulator, prevents syncytia
host-range, possible host defense modulator
host range protein
Hypothetical proteins
Hypothetical proteins: Conserved
Hypothetical proteins: Domain
in virion, inactive
Mobile and extrachromosomal element functions
Mobile and extrachromosomal element functions: Other
Mobile and extrachromosomal element functions: Plasmid functions
Mobile and extrachromosomal element functions: Prophage functions
#N/A
N/A
No Data
Protein fate
Protein fateCellular processes,
Protein fate: Degradation of proteins, peptides, and glycopeptides
Protein fateEnergy metabolism,DNA metabolism,
Protein fate: Protein and peptide secretion and trafficking
Protein fate: Protein folding and stabilization
Protein fate: Protein modification and repair
Protein fateRegulatory functions
Protein fateRegulatory functions,
Protein synthesis
Protein synthesis: Ribosomal proteins: synthesis and modification
Protein synthesis: tRNA aminoacylation
Protein synthesis: tRNA and rRNA base modification
Purines, pyrimidines, nucleosides, and nucleotides
Purines, pyrimidines, nucleosides, and nucleotidesEnergy metabolism,
Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions
Purines, pyrimidines, nucleosides, and nucleotides: Other
Purines, pyrimidines, nucleosides, and nucleotidesProtein synthesis,
Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis
Purines, pyrimidines, nucleosides, and nucleotides: Salvage of nucleosides and nucleotides
Purines, pyrimidines, nucleosides, and nucleotides: Sugar-nucleotide biosynthesis and conversions
Purines, pyrimidines, nucleosides, and nucleotidesTransport and binding proteins,
Regulatory functions
Regulatory functionsAmino acid biosynthesis
Regulatory functionsAmino acid biosynthesis,
Regulatory functions: DNA interactions
Regulatory functionsDNA metabolism,
Regulatory functions: Other
Regulatory functions: RNA interactions
Regulatory functionsSignal transduction
Regulatory functionsSignal transduction,
Regulatory functionsTransport and binding proteins,
Signal transduction
Signal transduction: PTS
S-S bond formation pathway
Transcription
Transcription: Degradation of RNA
TranscriptionUnknown function,
Transport and binding proteins
Transport and binding proteins: Amino acids, peptides and amines
Transport and binding proteins: Anions
Transport and binding proteinsBiosynthesis of cofactors, prosthetic groups, and carriers,
Transport and binding proteins: Carbohydrates, organic alcohols, and acids
Transport and binding proteins: Cations and iron carrying compounds
Transport and binding proteins: Nucleosides, purines and pyrimidines
Transport and binding proteins: Other
Transport and binding proteins: Unknown substrate
Unclassified
Unclassified: Role category not yet assigned
unknown
unknown, conserved protein
Unknown function
Unknown function: Enzymes of unknown specificity
Unknown function: General
Viral functions
Viral functions: General
Organism:
No Filter
Acinetobacter baumannii
Acinetobacter baumannii ATCC 17978
Acinetobacter baumannii SDF
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae serovar 5b str. L20
Agrobacterium tumefaciens str. C58
Aquifex aeolicus VF5
Bacillus anthracis str. Ames
Bacillus anthracis str. 'Ames Ancestor'
Bacillus anthracis str. Sterne
Bacillus subtilis
Bacillus subtilis subsp. subtilis str. 168
Bacteroides thetaiotaomicron VPI-5482
Bifidobacterium longum subsp. infantis ATCC 15697
Bordetella pertussis Tohama I
Borrelia burgdorferi B31
Burkholderia mallei ATCC 23344
Burkholderia pseudomallei K96243
Burkholderia pseudomallei MSHR346
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
Cell fusing agent virus
Chlamydia muridarum Nigg
Chlamydia trachomatis
Chlamydia trachomatis D/UW-3/CX
Clostridium difficile 630
Clostridium perfringens ATCC 13124
Cowpox virus
Cowpox virus (Brighton Red)
Coxiella burnetii RSA 493
Coxsackievirus B3 (strain Woodruff)
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecalis V583
Enterococcus faecium
Enterococcus faecium DO
Enterococcus gallinarum
Escherichia coli
Escherichia coli 042
Escherichia coli CFT073
Escherichia coli ETEC H10407
Escherichia coli O103:H2 str. 12009
Escherichia coli O157:H7 str. EDL933
Escherichia coli O157:H7 str. Sakai
Escherichia coli str. K-12 substr. MG1655
Escherichia coli UTI89
Francisella novicida U112
Francisella tularensis subsp. holarctica LVS
Francisella tularensis subsp. tularensis SCHU S4
Haemophilus influenzae PittII
Helicobacter pylori
Helicobacter pylori 26695
Helicobacter pylori J99
Herpesvirus saimiri (strain 488)
Homo sapiens
Human echovirus 7
Human herpesvirus 6
Human herpesvirus 8
Human herpesvirus 8 type M
Influenza A virus (A/Aichi/2/1968(H3N2))
Influenza A virus (A/California/07/2009(H1N1))
Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Influenza A virus (A/udorn/1972(H3N2))
Influenza B virus (B/Lee/40)
Japanese encephalitis virus
Legionella pneumophila 130b
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Listeria monocytogenes
Listeria monocytogenes EGD-e
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis str. MC2 155
Mycobacterium tuberculosis H37Rv
Myxoma virus (strain Lausanne)
Neisseria gonorrhoeae
Neisseria gonorrhoeae FA 1090
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa UCBPP-PA14
Pseudomonas fluorescens Pf-5
Pseudomonas putida KT2440
Rickettsia prowazekii str. Madrid E
Rio Bravo virus
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Salmonella enterica subsp. enterica serovar Typhimurium
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
SARS coronavirus
Shigella dysenteriae 1012
Shigella dysenteriae Sd197
Shigella flexneri
Shigella flexneri 2a str. 2457T
Shigella flexneri 2a str. 301
Staphylococcus aureus
Staphylococcus aureus subsp. aureus COL
Staphylococcus aureus subsp. aureus MRSA252
Staphylococcus aureus subsp. aureus Mu3
Staphylococcus aureus subsp. aureus Mu50
Staphylococcus aureus subsp. aureus N315
Staphylococcus aureus subsp. aureus NCTC 8325
Staphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus USA300_TCH1516
Staphylococcus epidermidis
Staphylococcus epidermidis RP62A
Staphylococcus haemolyticus
St. Louis encephalitis virus (strain MS1-7)
Streptococcus agalactiae 2603V/R
Streptococcus agalactiae A909
Streptococcus agalactiae NEM316
Streptococcus bovis ATCC 700338
Streptococcus downei F0415
Streptococcus dysgalactiae subsp. equisimilis
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equinus ATCC 9812
Streptococcus equi subsp. zooepidemicus
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34
Streptococcus infantarius subsp. infantarius ATCC BAA-102
Streptococcus mutans UA159
Streptococcus parauberis KCTC 11537
Streptococcus pneumoniae
Streptococcus pneumoniae G54
Streptococcus pneumoniae Hungary19A-6
Streptococcus pneumoniae P1031
Streptococcus pneumoniae R6
Streptococcus pneumoniae str. Canada MDR_19A
Streptococcus pneumoniae str. Canada MDR_19F
Streptococcus pneumoniae TCH8431/19A
Streptococcus pneumoniae TIGR4
Streptococcus porcinus str. Jelinkova 176
Streptococcus pyogenes
Streptococcus pyogenes M1 GAS
Streptococcus pyogenes MGAS5005
Streptococcus pyogenes NZ131
Streptococcus pyogenes str. Manfredo
Streptococcus sp. 'group G'
Streptococcus suis P1/7
Streptococcus suis SC84
Streptococcus thermophilus LMD-9
Streptococcus thermophilus LMG 18311
Streptococcus uberis 0140J
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Toxoplasma gondii GT1
Toxoplasma gondii ME49
Treponema pallidum subsp. pallidum str. Nichols
Vaccinia virus
Vaccinia virus Copenhagen
Vaccinia virus L-IPV
Vaccinia virus WR
Vibrio cholerae
Vibrio cholerae O1 biovar El Tor str. N16961
Vibrio cholerae O395
Vibrio fischeri ES114
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio parahaemolyticus RIMD 2210633
Vibrio sp. AND4
Vibrio vulnificus CMCP6
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis CO92
Yersinia pestis KIM10+
Yersinia pseudotuberculosis IP 32953
Zaire ebolavirus
Species:
No Filter
Acinetobacter baumannii
Acinetobacter haemolyticus
Acinetobacter sp. ATCC 27244
Actinobacillus pleuropneumoniae
Agrobacterium tumefaciens
Aliivibrio fischeri
Aquifex aeolicus
Bacillus anthracis
Bacillus subtilis
Bacteroides thetaiotaomicron
Bifidobacterium longum
Bordetella pertussis
Borrelia burgdorferi
Burkholderia mallei
Burkholderia pseudomallei
Campylobacter jejuni
Cell fusing agent virus
Chlamydia muridarum
Chlamydia trachomatis
[Clostridium] difficile
Clostridium perfringens
Cowpox virus
Coxiella burnetii
Dengue virus
Ectromelia virus
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Enterococcus gallinarum
Escherichia coli
Francisella novicida
Francisella tularensis
Haemophilus influenzae
Helicobacter pylori
Homo sapiens
Human enterovirus B
Human herpesvirus 6
Human herpesvirus 8
Influenza A virus
Influenza B virus
Japanese encephalitis virus
Legionella pneumophila
Listeria monocytogenes
Modoc virus
Monkeypox virus
Montana myotis leukoencephalitis virus
Murid herpesvirus 4
Murray Valley encephalitis virus
Mus musculus
Mycobacterium smegmatis
Mycobacterium tuberculosis
Myxoma virus
Neisseria gonorrhoeae
Proteus mirabilis
Providencia stuartii
Pseudomonas aeruginosa
Pseudomonas fluorescens
Pseudomonas putida
Rickettsia prowazekii
Rio Bravo virus
Saimiriine herpesvirus 2
Salmonella enterica
Severe acute respiratory syndrome-related coronavirus
Shigella dysenteriae
Shigella flexneri
Staphylococcus aureus
Staphylococcus epidermidis
Staphylococcus haemolyticus
St. Louis encephalitis virus
Streptococcus agalactiae
Streptococcus downei
Streptococcus dysgalactiae
Streptococcus equi
Streptococcus equinus
Streptococcus gallolyticus
Streptococcus infantarius
Streptococcus mutans
Streptococcus parauberis
Streptococcus pneumoniae
Streptococcus porcinus
Streptococcus pyogenes
Streptococcus sp. 'group G'
Streptococcus suis
Streptococcus thermophilus
Streptococcus uberis
Streptomyces fradiae
Streptomyces griseus
Streptomyces toyocaensis
synthetic construct
Toxoplasma gondii
Treponema pallidum
Vaccinia virus
Vibrio cholerae
Vibrio mimicus
Vibrio parahaemolyticus
Vibrio sp. AND4
Vibrio vulnificus
Western equine encephalomyelitis virus
West Nile virus
Yellow fever virus
Yersinia pestis
Yersinia pseudotuberculosis
Zaire ebolavirus
Priority:
No Filter
0
1
6
8
Keyword:
Type Keyword
Stage:
No Filter
cloned
crystallized
crystal_structure
diffraction
expressed
in_crystallization_trials
in_pdb
purified
selected
soluble
work_stopped
Clone Location
No Filter
Argonne National Laboratory
Collaborators of the CSGID
J. Craig Venter Institute
Northwestern University
University of Toronto
University of Texas Southwestern Medical Center
University of Virginia
Washington University
Screening
No Filter
Yes
No
Remove Filters
Download data as tab-separated value (TSV) file
(which can be used as a input for Microsoft Office Excel and Open Office Calc)
Jump to Target:
In
IDP#
NCBI GI
LOCUS TAG
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Page 18 of 60, showing 100 records out of 5973 total, starting on record 1701
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CSGID ID
Priority
stage
Screening
Locus Tag
NCBI GI
Gene
Name
Common Name
Sequence
Length
Justification
Selection
Phase
Homolog
PDB ID
Homolog
Sequence
Identity
Target Organism
TIGR Main Role
TIGR Subrole
Request Person
IDP01478
(
show subtarget assignments
)
1
purified
No
VC2772
15642765
ParB family protein
293
Conserved Gene / Pathway
Phase 2: March 2008
1VZ0
33.8%
Vibrio cholerae
Cellular processes
Cell division
IDP00410
(
show subtarget assignments
)
1
cloned
No
YPO0548
16120876
ftsL
cell division protein FtsL
105
Conserved Gene / Pathway
Phase 2: March 2008
Yersinia pestis
Cellular processes
Cell division
IDP04087
(
show subtarget assignments
)
1
cloned
No
CPF_2394
110799648
minC
septum formation inhibitor [Clostridium ...
211
conserved gene; putative drug target function;
Phase 4: April 2009
1HF2
29.7%
Clostridium perfringens
Cellular processes
Cell division
IDP02605
(
show subtarget assignments
)
1
cloned
No
YPO3502
16123648
hflB
ATP-dependent metalloprotease [Yersinia ...
644
Drug target motif; Conserved; CD; Drug target functions
Phase 3: June 2008
2DHR
40.7%
Yersinia pestis
Cellular processes
Cell division
IDP04265
(
show subtarget assignments
)
1
purified
No
CPF_2105
110800754
putative cell division protein DivIVA [C...
208
conserved gene; putative drug target function;
Phase 4: April 2009
2WUJ
12%
Clostridium perfringens
Cellular processes
Cell division
IDP02312
(
show subtarget assignments
)
1
expressed
No
GBAA2190
47778017
FtsK/SpoIIIE family protein [Bacillus an...
1342
Conserved; Involved in sporulation; Drug target functions
Phase 3: June 2008
2IUT
7.4%
Bacillus anthracis
Cellular processes
Cell division
IDP01443
(
show subtarget assignments
)
1
soluble
No
VC2061
15642061
ParA family protein
258
Conserved Gene / Pathway
Phase 2: March 2008
1WCV
34.1%
Vibrio cholerae
Cellular processes
Cell division
IDP04020
(
show subtarget assignments
)
1
cloned
No
CPF_2112
110800515
cell division protein FtsQ [Clostridium ...
248
conserved gene; putative drug target function;
Phase 4: April 2009
Clostridium perfringens
Cellular processes
Cell division
IDP00714
(
show subtarget assignments
)
1
cloned
No
SACOL1198
57285941
ftsA
cell division protein FtsA
470
Drug Target Function
Phase 2: March 2008
1E4F
18.3%
Staphylococcus aureus
Cellular processes
Cell division
IDP02714
(
show subtarget assignments
)
1
purified
No
FTT1231
56708293
mesJ
PP-loop family protein [Francisella tula...
398
Conserved; Drug target functions
Phase 3: June 2008
1NI5
27.3%
Francisella tularensis
Cellular processes
Cell division
IDP04010
(
show subtarget assignments
)
1
cloned
No
CPF_2393
110798628
minD
septum site-determining protein MinD [Cl...
265
conserved gene; putative drug target function;
Phase 4: April 2009
3Q9L
43.4%
Clostridium perfringens
Cellular processes
Cell division
IDP02831
(
show subtarget assignments
)
1
crystallized
No
GBAA4686
47529986
maf
Maf-like protein [Bacillus anthracis str...
191
Conserved; Drug target functions
Phase 3: June 2008
1EX2
53.4%
Bacillus anthracis
Cellular processes
Cell division
IDP00076
(
show subtarget assignments
)
1
in_pdb
3NX4
No
NT01ST4228
16421936
yhdH
putative oxidoreductase
324
These targets are similar to actual drug targets and will be used mostly for coc...
Phase 1: October 2007
3NX4
100%
Salmonella enterica
Cellular processes
Cell division
IDP04036
(
show subtarget assignments
)
1
cloned
No
CPF_1970
110800938
smc
chromosome segregation protein SMC [Clos...
1185
conserved gene; putative drug target function;
Phase 4: April 2009
3AUX
8.2%
Clostridium perfringens
Cellular processes
Cell division
IDP01360
(
show subtarget assignments
)
1
purified
No
VC0148
15640179
cell division ATP-binding protein FtsE
233
Conserved Gene / Pathway
Phase 2: March 2008
2PCJ
35.6%
Vibrio cholerae
Cellular processes
Cell division
IDP01342
(
show subtarget assignments
)
1
soluble
No
VC1960
15641962
septum site-determining protein MinD
276
Conserved Gene / Pathway
Phase 2: March 2008
3Q9L
73.6%
Vibrio cholerae
Cellular processes
Cell division
IDP01339
(
show subtarget assignments
)
1
purified
No
VC2397
15642394
cell division protein FtsZ
398
Conserved Gene / Pathway
Phase 2: March 2008
2VAW
58.6%
Vibrio cholerae
Cellular processes
Cell division
IDP00678
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1624
57286146
era
GTP-binding protein Era
299
Conserved Gene / Pathway
Phase 2: March 2008
3IEV
45.2%
Staphylococcus aureus
Cellular processes
Cell division
IDP01327
(
show subtarget assignments
)
1
purified
No
VC0418
15640445
maf
Maf-like protein
205
Conserved Gene / Pathway
Phase 2: March 2008
1EX2
40%
Vibrio cholerae
Cellular processes
Cell division
IDP00669
(
show subtarget assignments
)
1
cloned
No
SACOL1199
57285942
ftsZ
cell division protein FtsZ
390
Drug Target Function
Phase 2: March 2008
2VAM
68.7%
Staphylococcus aureus
Cellular processes
Cell division
IDP02166
(
show subtarget assignments
)
1
cloned
No
FTT0188
56707353
ftsZ
cell division protein FtsZ [Francisella ...
381
Conserved; Drug target functions
Phase 3: June 2008
2VAW
55.9%
Francisella tularensis
Cellular processes
Cell division
IDP00631
(
show subtarget assignments
)
1
in_crystallization_trials
No
SACOL1537
57284636
scpB
segregation and condensation protein B
180
Conserved Gene / Pathway
Phase 2: March 2008
1T6S
23.9%
Staphylococcus aureus
Cellular processes
Cell division
IDP02788
(
show subtarget assignments
)
1
expressed
No
CBU_0140
29540760
ftsA
cell division protein FtsA [Coxiella bur...
410
Conserved; Drug target functions
Phase 3: June 2008
1E4F
22.9%
Coxiella burnetii
Cellular processes
Cell division
IDP01153
(
show subtarget assignments
)
1
cloned
No
BA_5712
30260159
yycI protein
280
Conserved Gene / Pathway
Phase 2: March 2008
2O3O
28.2%
Bacillus anthracis
Cellular processes
Cell division
IDP02789
(
show subtarget assignments
)
1
cloned
No
CBU_0141
29540761
ftsZ
cell division protein FtsZ [Coxiella bur...
386
Conserved; Drug target functions
Phase 3: June 2008
2VAW
63.4%
Coxiella burnetii
Cellular processes
Cell division
IDP04042
(
show subtarget assignments
)
1
cloned
No
CPF_0296
110798725
putative cell division ATP-binding prote...
228
conserved gene; putative drug target function;
Phase 4: April 2009
1F3O
40.6%
Clostridium perfringens
Cellular processes
Cell division
IDP02279
(
show subtarget assignments
)
1
crystallized
No
FTT1164c
56708234
era
GTP-binding protein Era [Francisella tul...
297
Drug Target
Phase 3: June 2008
1EGA
48.5%
Francisella tularensis
Cellular processesRegulatory functions
Cell divisionRNA interactions
IDP01879
(
show subtarget assignments
)
1
cloned
No
FTT1804c
56708790
rng
ribonuclease G [Francisella tularensis s...
498
Conserved; Drug target functions
Phase 3: June 2008
2BX2
31.9%
Francisella tularensis
Cellular processesTranscription
Cell divisionRNA processing
IDP02252
(
show subtarget assignments
)
1
soluble
No
YPO1229
16121516
tsr2
putative methyl-accepting chemotaxis pro...
595
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
27.4%
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP01089
(
show subtarget assignments
)
1
soluble
No
STM4533
16767777
tsr
methyl-accepting chemotaxis protein I
553
Conserved Gene / Pathway
Phase 2: March 2008
3ZX6
49.5%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01047
(
show subtarget assignments
)
1
cloned
No
STM3152
16766452
putative methyl-accepting chemotaxis pro...
547
Conserved Gene / Pathway
Phase 2: March 2008
3ZX6
34.7%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00997
(
show subtarget assignments
)
1
soluble
No
STM2314
16765641
putative chemotaxis signal transduction ...
333
Conserved Gene / Pathway
Phase 2: March 2008
1K68
12%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP02634
(
show subtarget assignments
)
1
cloned
No
Cj1125c
15792450
wlaG
general glycosylation pathway protein [C...
376
Known Predicted virulence-N-linked protein glycoslyation; Predicted virulence-Po...
Phase 3: June 2008
2JJM
22.6%
Campylobacter jejuni
Cellular processes
Chemotaxis and motility
IDP00980
(
show subtarget assignments
)
1
in_crystallization_trials
No
STM1970
16765308
fliG
flagellar motor switch protein G
331
Conserved Gene / Pathway
Phase 2: March 2008
3HJL
28.7%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01981
(
show subtarget assignments
)
1
soluble
No
STM1969
16765307
fliF
flagellar MS-ring protein [Salmonella ty...
560
Drug target motif; Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01957
(
show subtarget assignments
)
1
expressed
No
STM1657
16765001
putative methyl-accepting chemotaxis pro...
384
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
32.6%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01955
(
show subtarget assignments
)
1
cloned
No
STM1980
16765318
fliQ
flagellar biosynthesis protein FliQ [Sal...
89
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01940
(
show subtarget assignments
)
1
cloned
No
STM1626
16764970
trg
methyl-accepting chemotaxis protein III ...
541
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
35.5%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP01924
(
show subtarget assignments
)
1
purified
No
lmo0692
16802734
cheA
two-component sensor histidine kinase Ch...
618
Known virulence-Regulation; PMID:15155625
Phase 3: June 2008
1B3Q
26.5%
Listeria monocytogenes
Cellular processes
Chemotaxis and motility
IDP00212
(
show subtarget assignments
)
1
expressed
No
YPO2123
16122358
-
putative phage minor tail protein
236
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP00211
(
show subtarget assignments
)
1
purified
No
YPO2101
16122340
-
hypothetical phage protein
211
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP00209
(
show subtarget assignments
)
1
soluble
No
YPO2062
16122301
-
putative M23/M37 peptidase-family protei...
417
Virulence
Phase 1: October 2007
2GU1
32.4%
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP02076
(
show subtarget assignments
)
1
soluble
No
STM3216
16766515
putative methyl-accepting chemotaxis pro...
521
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
28.6%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00100
(
show subtarget assignments
)
0
work_stopped
No
NT01SF2345
30041591
cheW
positive regulator of CheA protein activ...
167
Phase 1: October 2007
2HO9
100%
Shigella flexneri
Cellular processes
Chemotaxis and motility
IDP02090
(
show subtarget assignments
)
1
cloned
No
STM3577
16766863
tcp
methyl-accepting transmembrane citrate/p...
547
Conserved; Drug target functions
Phase 3: June 2008
3ZX6
40%
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP00189
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0845
16121153
-
ThiJ/PfpI-family thiamine biogenesis pro...
192
Virulence
Phase 1: October 2007
1J42
29.2%
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP04179
(
show subtarget assignments
)
1
cloned
No
VCA0068
15600839
methyl-accepting chemotaxis protein [Vib...
547
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3ZX6
18.3%
Vibrio cholerae
Cellular processes
Chemotaxis and motility
IDP00188
(
show subtarget assignments
)
1
purified
No
YPO0806
16121118
-
prepilin peptidase
280
Virulence
Phase 1: October 2007
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP04168
(
show subtarget assignments
)
1
purified
No
VC2142
15642141
flagellin [Vibrio cholerae O1 biovar elt...
376
drug target; conserved gene; putative drug target function;
Phase 4: April 2009
3K8V
37.5%
Vibrio cholerae
Cellular processes
Chemotaxis and motility
IDP04260
(
show subtarget assignments
)
1
cloned
No
CPF_2020
110798885
pilT
twitching motility protein PilT [Clostri...
350
conserved gene; putative drug target function;
Phase 4: April 2009
2EWV
49.1%
Clostridium perfringens
Cellular processes
Chemotaxis and motility
IDP01603
(
show subtarget assignments
)
1
cloned
No
STM1971
16765309
fliH
flagellar assembly protein H [Salmonella...
235
Conserved; Drug target functions
Phase 3: June 2008
Salmonella enterica
Cellular processes
Chemotaxis and motility
IDP02422
(
show subtarget assignments
)
1
cloned
No
YPO1666
16121930
cheA
chemotaxis protein CheA [Yersinia pestis...
723
Conserved; CD; Drug target functions
Phase 3: June 2008
1B3Q
22.7%
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP02557
(
show subtarget assignments
)
1
purified
No
Cj0061c
15791453
fliA
flagellar biosynthesis sigma factor [Cam...
238
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
1RP3
35.3%
Campylobacter jejuni
Cellular processes
Chemotaxis and motility
IDP02358
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1667
16121931
cheW
purine-binding chemotaxis protein [Yersi...
165
Conserved; Drug target functions
Phase 3: June 2008
2HO9
83%
Yersinia pestis
Cellular processes
Chemotaxis and motility
IDP02654
(
show subtarget assignments
)
1
cloned
No
Cj1682c
15792986
gltA
citrate synthase [Campylobacter jejuni s...
422
Possible Vaccine Candidate; Predicted Essential-Modeling
Phase 3: June 2008
2H12
50.2%
Campylobacter jejuni
Cellular processes
Chemotaxis and motility
IDP02503
(
show subtarget assignments
)
1
cloned
No
YPO2502
16122723
gutB
putative zinc-binding dehydrogenase [Yer...
408
CD; Proteomics evidence (Cytoplasmid or periplasmic); Drug target functions
Phase 3: June 2008
2D8A
30.1%
Yersinia pestis
Biosynthesis of cofactors, prosthetic groups, and carriers
Chlorophyll and bacteriochlorphyll
IDP02343
(
show subtarget assignments
)
1
expressed
No
STM0345
16763725
putative inner membrane protein [Salmone...
162
Essential; Drug target functions
Phase 3: June 2008
Salmonella enterica
Hypothetical proteins
Conserved
IDP02267
(
show subtarget assignments
)
1
soluble
No
GBAA0987
47526266
hypothetical protein GBAA0987 [Bacillus ...
66
Conserved;
Phase 3: June 2008
Bacillus anthracis
Hypothetical proteins
Conserved
IDP02296
(
show subtarget assignments
)
1
crystallized
No
GBAA0020
47525275
hypothetical protein GBAA0020 [Bacillus ...
109
Conserved; Involved in sporulation;
Phase 3: June 2008
1YBX
55.8%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP04734
(
show subtarget assignments
)
1
cloned
No
YPO1485
115347237
conserved hypothetical protein [Yersinia...
587
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP00233
(
show subtarget assignments
)
1
cloned
No
YPO3676
16123819
-
putative phage-related protein
133
Virulence
Phase 1: October 2007
2VO9
25.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP02109
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO1186
16121481
hypothetical protein YPO1186 [Yersinia p...
157
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Hypothetical proteins
Conserved
IDP04711
(
show subtarget assignments
)
1
in_crystallization_trials
No
YPO0513
115346323
conserved hypothetical protein [Yersinia...
451
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04709
(
show subtarget assignments
)
1
cloned
No
YPO0501
115346310
conserved hypothetical protein [Yersinia...
503
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP00227
(
show subtarget assignments
)
1
expressed
No
YPO3249
16123408
-
putative amino acid hydrolase
430
Virulence
Phase 1: October 2007
3N5F
36%
Yersinia pestis
Hypothetical proteins
Conserved
IDP04725
(
show subtarget assignments
)
1
selected
No
YPO1467
115347221
conserved hypothetical protein [Yersinia...
450
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04699
(
show subtarget assignments
)
1
expressed
No
YPCD1.53
16082741
yscD
virulence protein [Yersinia pestis CO92]...
419
virulence factor; conserved gene;
Phase 4: April 2009
4A0E
28.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP02081
(
show subtarget assignments
)
1
cloned
No
Cj1340c
15792663
hypothetical protein Cj1340c [Campylobac...
605
Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02105
(
show subtarget assignments
)
1
cloned
No
lmo0063
16802111
hypothetical protein lmo0063 [Listeria m...
99
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP04629
(
show subtarget assignments
)
1
soluble
No
CBU_0151
29653509
queF
7-cyano-7-deazaguanine reductase [Coxiel...
278
drug target; conserved gene;
Phase 4: April 2009
3BP1
51.4%
Coxiella burnetii
Hypothetical proteins
Conserved
IDP01988
(
show subtarget assignments
)
1
cloned
No
Cj1032
15792359
hypothetical protein Cj1032 [Campylobact...
246
Predicted virulence-Resistance to antibiotics and toxic compounds
Phase 3: June 2008
4DK1
19.1%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02500
(
show subtarget assignments
)
1
in_pdb
3SY3
3TJ7
Yes
GBAA1210
47526472
hypothetical protein GBAA1210 [Bacillus ...
192
Drug target motif;
Phase 3: June 2008
3SY3
99.5%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP01973
(
show subtarget assignments
)
1
expressed
No
Cj1440c
15792758
putative sugar transferase [Campylobacte...
407
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
2Z86
15.5%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02582
(
show subtarget assignments
)
1
soluble
No
Cj1349c
15792672
fibronectin/fibrinogen-binding protein [...
435
Predicted virulence-Adhesion of Campylobacter
Phase 3: June 2008
3DOA
10.6%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02222
(
show subtarget assignments
)
1
crystallized
No
lmo0484
16802527
heme-degrading monooxygenase IsdG [Liste...
121
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
1TZ0
28.9%
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP02079
(
show subtarget assignments
)
1
expressed
No
Cj0173c
15791560
iron ABC transporter, ATP binding subuni...
302
Predicted virulence-Iron Scavenging Mechanisms
Phase 3: June 2008
2D62
35.4%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP04486
(
show subtarget assignments
)
1
cloned
No
YPO3597
115349218
conserved hypothetical protein [Yersinia...
448
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP01944
(
show subtarget assignments
)
1
cloned
No
Cj1427c
15792745
putative sugar-nucleotide epimerase/dehy...
313
Known Predicted virulence-capsule biosynthesis anmd transport; Predicted virulen...
Phase 3: June 2008
3ICP
28.4%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP01943
(
show subtarget assignments
)
1
crystallized
No
Cj1425c
15792743
putative sugar kinase [Campylobacter jej...
339
Known Predicted virulence-capsule biosynthesis anmd transport; PMID:15808749
Phase 3: June 2008
3K85
48.7%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP01941
(
show subtarget assignments
)
1
purified
No
Cj1424c
15792742
gmhA2
putative phosphoheptose isomerase [Campy...
201
Known Predicted virulence-capsule biosynthesis anmd transport; Predicted Essenti...
Phase 3: June 2008
2X3Y
55.7%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP02233
(
show subtarget assignments
)
1
cloned
No
lmo0056
16802104
hypothetical protein lmo0056 [Listeria m...
97
Predicted virulence-Type III; Type IV; ESAT secretion systems
Phase 3: June 2008
2VRZ
50.5%
Listeria monocytogenes
Hypothetical proteins
Conserved
IDP02474
(
show subtarget assignments
)
1
cloned
No
Cj0922c
15792251
pebC
amino acid ABC transporter ATP-binding p...
242
Predicted virulence-Adhesion of Campylobacter
Phase 3: June 2008
2OLJ
52.5%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP00215
(
show subtarget assignments
)
1
cloned
No
YPO2295
16122519
-
haloacid dehalogenase-like hydrolase fam...
224
Virulence
Phase 1: October 2007
3ED5
31.6%
Yersinia pestis
Hypothetical proteins
Conserved
IDP04465
(
show subtarget assignments
)
1
expressed
No
YPO1994
115347715
hypothetical protein [Yersinia pestis CO...
316
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP02385
(
show subtarget assignments
)
1
cloned
No
Cj0755
15792094
cfrA
putative iron uptake protein [Campylobac...
696
Predicted virulence-Iron Scavenging Mechanisms; Possible Vaccine Candidate
Phase 3: June 2008
2HDF
29.8%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP04456
(
show subtarget assignments
)
1
soluble
No
YPO1382
115347141
hypothetical protein [Yersinia pestis CO...
224
drug target; virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04458
(
show subtarget assignments
)
1
soluble
No
YPO1466
115347220
conserved hypothetical protein [Yersinia...
516
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP01884
(
show subtarget assignments
)
1
soluble
No
Cj0042
15791441
flgD
flagellar basal body rod modification pr...
294
Known Predicted virulence-flagella; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP01874
(
show subtarget assignments
)
1
cloned
No
GBAA0062
47525316
hypothetical protein GBAA0062 [Bacillus ...
476
Conserved;
Phase 3: June 2008
3A2K
46.6%
Bacillus anthracis
Hypothetical proteins
Conserved
IDP00207
(
show subtarget assignments
)
1
soluble
No
YPO1950
16122196
-
putative peptidase
405
Virulence
Phase 1: October 2007
1WN1
23.7%
Yersinia pestis
Hypothetical proteins
Conserved
IDP02209
(
show subtarget assignments
)
1
cloned
No
Cj1337
15792660
hypothetical protein Cj1337 [Campylobact...
628
Known Predicted virulence-O-linked flagellar glycoslyation; PMID:15738950
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP01856
(
show subtarget assignments
)
1
expressed
No
Cj1152c
15792476
putative phosphatase [Campylobacter jeju...
186
Known Predicted virulence-LOS-Immune evasion and molecular mimcry; PMID:15578098...
Phase 3: June 2008
2GMW
37.1%
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP00204
(
show subtarget assignments
)
1
expressed
No
YPO1702
16121962
-
putative membrane protein
450
Virulence
Phase 1: October 2007
Yersinia pestis
Hypothetical proteins
Conserved
IDP04705
(
show subtarget assignments
)
1
cloned
No
YPO0499
115346308
hypothetical protein [Yersinia pestis CO...
337
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP01837
(
show subtarget assignments
)
1
cloned
No
YPO1244
16121530
hypothetical protein YPO1244 [Yersinia p...
99
Conserved; Involved in virulence; Drug target functions
Phase 3: June 2008
Yersinia pestis
Hypothetical proteins
Conserved
IDP02494
(
show subtarget assignments
)
1
cloned
No
GBAA0550
47525823
hypothetical protein GBAA0550 [Bacillus ...
631
Drug target motif; Conserved;
Phase 3: June 2008
Bacillus anthracis
Hypothetical proteins
Conserved
IDP04316
(
show subtarget assignments
)
1
expressed
No
YPO0503
115346312
conserved hypothetical protein [Yersinia...
147
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP02214
(
show subtarget assignments
)
1
soluble
No
Cj0041
15791440
hypothetical protein Cj0041 [Campylobact...
598
Known Predicted virulence-flagella; Possible Vaccine Candidate; PMID:8478066
Phase 3: June 2008
Campylobacter jejuni
Hypothetical proteins
Conserved
IDP04278
(
show subtarget assignments
)
1
soluble
No
YPO0504
115346313
conserved hypothetical protein [Yersinia...
614
virulence factor; conserved gene;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
IDP04282
(
show subtarget assignments
)
1
selected
No
YPO1465
115347219
conserved hypothetical protein [Yersinia...
166
virulence factor;
Phase 4: April 2009
Yersinia pestis
Hypothetical proteins
Conserved
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