Center for Structural Genomics of Infectious Diseases


CSGID ID	Priority	stage	Screening	Locus Tag	NCBI GI	Gene Name	Common Name	Sequence Length	Justification	Selection Phase	Homolog PDB ID	Homolog Sequence Identity	Target Organism	TIGR Main Role	TIGR Subrole	Request Person
IDP05152 (show subtarget assignments)	1	cloned	No	BA_0420	30253954		conserved hypothetical protein [Bacillus...	265	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05151 (show subtarget assignments)	1	purified	No	BA_0307	30253847		putative lipoprotein [Bacillus anthracis...	397	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2QX2	29%	Bacillus anthracis	Cell envelope: Other

IDP05511 (show subtarget assignments)	1	soluble	No	BA_5634	30260085		putative lipoprotein [Bacillus anthracis...	196	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05500 (show subtarget assignments)	1	cloned	No	CD0261	126697833	fliQ	flagellar export protein [Clostridium di...	89	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05611 (show subtarget assignments)	1	expressed	No	BA_5156	30259642		conserved hypothetical protein [Bacillus...	208	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP91260 (show subtarget assignments)	8	soluble	No	NT02SA2397	14248172	nasF	uroporphyrin-III C-methyl transferase [S...	325	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1PJQ	28%	Staphylococcus aureus	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91005 (show subtarget assignments)	8	soluble	No	y1936	22125828		ATP-binding component of a transport sys...	257	potential drug target / part of iron-sulfur cluster assembly system active under stress conditions	Community Requests	2ZU0	80.9%	Yersinia pestis

IDP04350 (show subtarget assignments)	1	cloned	No	STM1338_1_795	16764689	pheT	phenylalanyl-tRNA synthetase subunit bet...	795	Salmonella essential protein	Phase 4: April 2009	3PCO	92.6%	Salmonella enterica

IDP05499 (show subtarget assignments)	1	soluble	No	BA_4322	30258823		5'-nucleotidase family protein [Bacillus...	529	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2Z1A	30.2%	Bacillus anthracis	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05543 (show subtarget assignments)	1	cloned	No	CD2628	126700242		hypothetical protein CD2628 [Clostridium...	642	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05150 (show subtarget assignments)	1	in_crystallization_trials	No	BA_0195	30253702		putative oligopeptide ABC transporter, o...	546	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1B05	29.9%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05054 (show subtarget assignments)	1	cloned	No	CD0250	126697821	fliH	flagellar assembly protein [Clostridium ...	243	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04060 (show subtarget assignments)	8	selected	No	CAC05813	12329082	mxiI	MxiI, component of the Mxi-Spa secretion...	97	Shigella effector protein	Community Requests			Shigella flexneri

IDP05502 (show subtarget assignments)	1	cloned	No	CD0386	126697956		putative collagen-binding surface protei...	1014	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP05506 (show subtarget assignments)	1	soluble	No	CD1232	126698828		putative lipoprotein [Clostridium diffic...	273	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1NA0	15.8%	Clostridium difficile	Unknown function: General

IDP05507 (show subtarget assignments)	1	cloned	No	BA_5374	30259847		putative lipoprotein [Bacillus anthracis...	161	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05505 (show subtarget assignments)	1	cloned	No	CD1029	126698613		putative cell wall anchored protein [Clo...	553	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Regulatory functions: Other

IDP91081 (show subtarget assignments)	8	cloned	No	CD2817	126700433		ABC transporter, ATP-binding/permease pr...	596	drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...	Community Requests	3QF4	39.4%	Clostridium difficile

IDP91205 (show subtarget assignments)	8	soluble	No	BT_3975	29349383		3-dehydroquinate synthase [Bacteroides t...	353	potential drug target / Shikimate pathway enzyme	Community Requests	3CLH	34.3%	Bacteroides thetaiotaomicron

IDP05099 (show subtarget assignments)	1	cloned	No	CD0754	126698334	thiI	thiamine biosynthesis protein ThiI [Clos...	391	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2C5S	42.2%	Clostridium difficile	Protein synthesis: tRNA and rRNA base modification

IDP05022 (show subtarget assignments)	1	cloned	No	CD1145	126698740	mreB2	rod shape-determining protein MreB [Clos...	353	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1JCE	54.4%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05021 (show subtarget assignments)	1	soluble	No	CD1139	126698733	rnfG	electron transport complex protein [Clos...	189	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05749 (show subtarget assignments)	1	cloned	No	Cj0775c	6968216	valS	putative periplasmic protein [Campylobac...	870	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1GAX	38.2%	Campylobacter jejuni	Protein synthesis: tRNA aminoacylation

IDP05020 (show subtarget assignments)	1	soluble	No	CD1027	126698611	potD	spermidine/putrescine ABC transporter,su...	350	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4EQB	39.1%	Clostridium difficile	Transport and binding proteins: Amino acids, peptides and amines

IDP05508 (show subtarget assignments)	1	cloned	No	BA_5398	30259871		putative lipoprotein [Bacillus anthracis...	143	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05019 (show subtarget assignments)	1	expressed	No	CD0267	126697839		hypothetical protein CD0267 [Clostridium...	145	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Hypothetical proteins: Conserved

IDP05026 (show subtarget assignments)	1	cloned	No	BA_0025	30253539		putative csfB protein [Bacillus anthraci...	59	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: General

IDP04599 (show subtarget assignments)	1	cloned	No	BAS2268	49185277		aspartate-semialdehyde dehydrogenase [Ba...	347	Proposed to be essential proteins	Phase 4: April 2009	2GYY	55.3%	Bacillus anthracis

IDP04357 (show subtarget assignments)	1	in_crystallization_trials	No	FTT0894	56707995	purCD	fusion protein PurC/PurD [Francisella tu...	770	conserved gene; putative drug target function;	Phase 4: April 2009	2YRW	20.3%	Francisella tularensis

IDP05059 (show subtarget assignments)	1	soluble	No	CD0690	126698269		putative nucleotide phosphodiesterase [C...	655	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3GVE	15.3%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP05517 (show subtarget assignments)	1	soluble	No	CD1699	126699305	ribB	riboflavin synthase subunit alpha [Clost...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1KZL	38.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05183 (show subtarget assignments)	1	soluble	No	BA_5237	30259716		putative lipoprotein [Bacillus anthracis...	176	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP91381 (show subtarget assignments)	8	cloned	No	VV1_1469	27364853		Beta-galactosidase/beta-glucuronidase [V...	258	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests			Vibrio vulnificus

IDP04538 (show subtarget assignments)	8	in_crystallization_trials	No	CAC05770	12329039	ospB	OspB, protein secreted by the Mxi-Spa se...	288	Shigella effector protein	Community Requests			Shigella flexneri

IDP91051 (show subtarget assignments)	8	in_crystallization_trials	No	PRM0001	81687074	rmtC	16S rRNA methylase [Proteus mirabilis]	281	drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3B89	29.2%	Proteus mirabilis

IDP05516 (show subtarget assignments)	1	soluble	No	CD1697	126699303	ribH	riboflavin synthase beta chain (6,7-dime...	158	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RVV	66.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05024 (show subtarget assignments)	1	soluble	No	BAS4675	49187666	-	ABC transporter, substrate-binding prote...	325	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3IX1	20.6%	Bacillus anthracis	Unclassified: Role category not yet assigned

IDP05527 (show subtarget assignments)	1	cloned	No	CD2600	126700220		putative carbon starvation [Clostridium ...	473	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010			Clostridium difficile	Cellular processes: Adaptations to atypical conditions

IDP04623 (show subtarget assignments)	1	expressed	No	BAS4760	49187751		glucose-1-phosphate adenylyltransferase ...	376	Proposed to be essential proteins	Phase 4: April 2009	3BRK	40%	Bacillus anthracis

IDP04024 (show subtarget assignments)	1	cloned	No	BAS5319	49188303		DNA-binding response regulator YycF [Bac...	235	Proposed to be essential proteins	Phase 4: April 2009	2OQR	47.7%	Bacillus anthracis

IDP05514 (show subtarget assignments)	1	purified	No	CD1315	126698913	ribC	riboflavin biosynthesis protein [Clostri...	309	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1MRZ	32.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05513 (show subtarget assignments)	1	cloned	No	CD0278	126697850		putative transcriptional regulator [Clos...	130	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	4A5M	34.6%	Clostridium difficile	Regulatory functions: DNA interactions

IDP05518 (show subtarget assignments)	1	cloned	No	CD1702	126699308	thiC	thiamine biosynthesis protein ThiC [Clos...	438	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3EPM	43.1%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP04026 (show subtarget assignments)	1	expressed	No	FTT0456c	56707598		hypothetical protein FTT_0456c [Francise...	97	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1YHD	39.2%	Francisella tularensis

IDP05125 (show subtarget assignments)	1	cloned	No	BA_4310	30258811		putative lipoprotein [Bacillus anthracis...	246	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05029 (show subtarget assignments)	1	cloned	No	BA_0864	30254614		putative lipoprotein [Bacillus anthracis...	198	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP05520 (show subtarget assignments)	1	soluble	No	CD1822	126699430	bcp	putative thiol peroxidase (bacterioferri...	154	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3DRN	42.6%	Clostridium difficile	Cellular processes: Detoxification

IDP05519 (show subtarget assignments)	1	cloned	No	CD1704	126699311	thiG	thiazole synthase [Clostridium difficile...	261	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1XM3	47.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05521 (show subtarget assignments)	1	cloned	No	CD1858	126699468		putative cell surface protein [Clostridi...	526	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Cell envelope: Other

IDP04067 (show subtarget assignments)	1	purified	No	BAS4417	49187412		thioredoxin [Bacillus anthracis str. Ste...	104	Proposed to be essential proteins	Phase 4: April 2009	2GZY	75%	Bacillus anthracis

IDP05690 (show subtarget assignments)	1	cloned	No	lmo1666	16803706	-	peptidoglycan linked protein (LPXTG) [Li...	1711	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Listeria monocytogenes	Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05523 (show subtarget assignments)	1	soluble	No	CD2204	126699821		esterase [Clostridium difficile 630]	260	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2UZ0	33.5%	Clostridium difficile	Fatty acid and phospholipid metabolism: Degradation

IDP05098 (show subtarget assignments)	1	purified	No	CD0569	126698147		putative outer membrane lipoprotein [Clo...	334	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FQW	21.3%	Clostridium difficile	Cell envelope: Other

IDP04539 (show subtarget assignments)	8	in_crystallization_trials	No	CAC05775	12329044	ospD1	OspD1, secreted by the Mxi-Spa secretion...	225	Shigella effector protein	Community Requests			Shigella flexneri

IDP05526 (show subtarget assignments)	1	soluble	No	CD1319	126698918		putative polysaccharide deacetylase [Clo...	247	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2J13	27.1%	Clostridium difficile	Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05541 (show subtarget assignments)	1	cloned	No	CD3437	126701060	cobS	cobalamin synthase [Clostridium difficil...	257	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RH5	23.5%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05524 (show subtarget assignments)	1	cloned	No	CD2402	126700017		putative cell wall hydrolase [Clostridiu...	396	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3H41	20.5%	Clostridium difficile	Cellular processes: Sporulation and germination

IDP05025 (show subtarget assignments)	1	cloned	No	BAS4742	49187733	-	hypothetical protein BAS4742 [Bacillus a...	200	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05130 (show subtarget assignments)	1	cloned	No	CD0119	126697691		phosphoglucomutase/phosphomannomutase mu...	454	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3PDK	50.2%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP04025 (show subtarget assignments)	1	expressed	No	YPCD1.36c	16082724	yscX	hypothetical protein YPCD1.36c [Yersinia...	122	virulence factor; conserved gene;	Phase 4: April 2009			Yersinia pestis

IDP05056 (show subtarget assignments)	1	soluble	No	CD0257	126697829	motB	chemotaxis protein [Clostridium difficil...	231	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2K1S	20.3%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP05528 (show subtarget assignments)	1	in_pdb 4E1L	No	CD2676	126700290	thlA2	putative acetyl-CoA acetyltransferase [C...	392	virulence/pathogenesis / Targets associated with virulence and/or pathogenesis	Phase 5: 2010	4E1L	100%	Clostridium difficile	Cellular processes: Toxin production and resistance

IDP05680 (show subtarget assignments)	1	purified	No	lmo1221	16803261	pheS	phenylalanyl-tRNA synthetase subunit alp...	350	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	2RHQ	55.1%	Listeria monocytogenes	Protein synthesis: tRNA aminoacylation

IDP05174 (show subtarget assignments)	1	cloned	No	BA_2570	30257192		conserved hypothetical protein [Bacillus...	245	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP05540 (show subtarget assignments)	1	cloned	No	CD3515	126701139	glmU	bifunctional protein [Clostridium diffic...	459	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	4AAW	48.4%	Clostridium difficile	Central intermediary metabolism: Amino sugars

IDP04617 (show subtarget assignments)	1	expressed	No	BAS4342	49187337		50S ribosomal protein L21 [Bacillus anth...	102	Proposed to be essential proteins	Phase 4: April 2009	1VSA	54.9%	Bacillus anthracis

IDP05129 (show subtarget assignments)	1	cloned	No	CD0091	126697661	adk	adenylate kinase [Clostridium difficile ...	221	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3FB4	57.9%	Clostridium difficile	Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05028 (show subtarget assignments)	1	purified	No	BA_0331	30253869		polysaccharide deacetylase-like protein ...	367	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Unknown function: General

IDP04600 (show subtarget assignments)	1	cloned	No	BAS2547	49185555		preprotein translocase subunit SecY [Bac...	434	Proposed to be essential proteins	Phase 4: April 2009	3DIN	42.2%	Bacillus anthracis

IDP04066 (show subtarget assignments)	8	selected	No	CAC05819	12329088	mxiE	MxiE, similarities to transcriptional ac...	210	Shigella effector protein	Community Requests			Shigella flexneri

IDP05531 (show subtarget assignments)	1	cloned	No	CD2770	126700386		putative capsular polysaccharide biosynt...	363	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3C48	25.3%	Clostridium difficile	Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05530 (show subtarget assignments)	1	cloned	No	CD1534	126699138		putative gamma-glutamyltranspeptidase [C...	521	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2NLZ	54.7%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs

IDP05058 (show subtarget assignments)	1	in_crystallization_trials	No	CD0468	126698044	malL	oligo-1,6-glucosidase [Clostridium diffi...	554	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2ZE0	44%	Clostridium difficile	Energy metabolism: Sugars

IDP04601 (show subtarget assignments)	1	in_pdb 3RHI	Yes	BAS3574	49186575		DNA-binding protein HU [Bacillus anthrac...	90	Proposed to be essential proteins	Phase 4: April 2009	3RHI	100%	Bacillus anthracis

IDP05173 (show subtarget assignments)	1	expressed	No	BA_2528	30257152		N-acetylmuramoyl-L-alanine amidase, fami...	410	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3PYW	23.2%	Bacillus anthracis	Cell envelope: Surface structures

IDP05027 (show subtarget assignments)	1	purified	No	BA_0231	30253731		putative oligopeptide ABC transporter, o...	555	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRF	27.3%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP05154 (show subtarget assignments)	1	soluble	No	BA_0796	30254387		conserved hypothetical protein [Bacillus...	386	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Hypothetical proteins: Conserved

IDP04607 (show subtarget assignments)	1	cloned	No	BAS3700	49186699		ribonuclease III [Bacillus anthracis str...	245	Proposed to be essential proteins	Phase 4: April 2009	1O0W	40%	Bacillus anthracis

IDP05535 (show subtarget assignments)	1	cloned	No	CD3071	126700688		glycosyl hydrolase [Clostridium difficil...	692	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	2XVG	22.3%	Clostridium difficile	Unknown function: Enzymes of unknown specificity

IDP05533 (show subtarget assignments)	1	cloned	No	CD2149	126699765		hypothetical protein CD2149 [Clostridium...	419	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP05539 (show subtarget assignments)	1	in_pdb 4E16	No	CD3426	126701049	cbiF	precorrin-4 C(11)-methyltransferase [Clo...	250	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	4E16	100%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05534 (show subtarget assignments)	1	in_crystallization_trials	No	CD3106	126700723		putative phopho-sugar aldolase [Clostrid...	213	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	3R8R	35.2%	Clostridium difficile	Unknown function: General

IDP05538 (show subtarget assignments)	1	cloned	No	CD3392	126701015		putative collagen-binding surface protei...	1014	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Unknown function: General

IDP05127 (show subtarget assignments)	1	soluble	No	BA_4652	30259150		putative substrate-binding family protei...	314	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3HXP	29.6%	Bacillus anthracis	Transport and binding proteins: Unknown substrate

IDP05153 (show subtarget assignments)	1	soluble	No	BA_0656	30254258		oligopeptide ABC transporter, oligopepti...	593	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3DRF	32.4%	Bacillus anthracis	Transport and binding proteins: Amino acids, peptides and amines

IDP91384 (show subtarget assignments)	8	in_pdb 3UPD	Yes	VV1_1466	27364850		ornithine carbamoyltransferase [Vibrio v...	334	essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...	Community Requests	3UPD	100%	Vibrio vulnificus

IDP05128 (show subtarget assignments)	1	soluble	No	BA_5530	30259989		conserved hypothetical protein [Bacillus...	236	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	2FPN	29.2%	Bacillus anthracis	Hypothetical proteins: Conserved

IDP05537 (show subtarget assignments)	1	cloned	No	CD3419	126701042	hemB	delta-aminolevulinic acid dehydratase [C...	321	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1W5Q	55.2%	Clostridium difficile	Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05536 (show subtarget assignments)	1	cloned	No	CD3145	126700762		putative serine-aspartate-rich surface a...	1190	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	1YO8	7.6%	Clostridium difficile	Unknown function: General

IDP05057 (show subtarget assignments)	1	cloned	No	CD0266	126697838	fliA	RNA polymerase sigma factor for flagella...	233	essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...	Phase 5: 2010	1RP3	38.2%	Clostridium difficile	Cellular processes: Chemotaxis and motility

IDP04646 (show subtarget assignments)	1	soluble	No	FTT1085	56708168		hypothetical protein FTT_1085 [Francisel...	332	drug target; conserved gene; putative drug target function;	Phase 4: April 2009	1QXN	9.3%	Francisella tularensis

IDP91277 (show subtarget assignments)	8	soluble	No	NT05BA4403	49181145		conserved hypothetical protein [Bacillus...	336	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	1JQJ	17.3%	Bacillus anthracis	DNA metabolism: DNA replication, recombination, and repair

IDP05248 (show subtarget assignments)	1	expressed	No	lmo2691	16804728	-	autolysin [Listeria monocytogenes EGD-e]...	590	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010	3FI7	16.1%	Listeria monocytogenes	Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91219 (show subtarget assignments)	1	cloned	No	SAOUHSC_01359	110810462		RecName: Full=Phosphatidylglycerol lysyl...	840	virulence/pathogenesis / Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound...	Community Requests			Staphylococcus aureus

IDP05134 (show subtarget assignments)	1	soluble	No	CD0555	126698134	sip2	singal peptidase I [Clostridium difficil...	178	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Clostridium difficile	Protein fate: Protein and peptide secretion and trafficking

IDP05141 (show subtarget assignments)	1	cloned	No	BAS2021	49185032	argS	arginyl-tRNA synthetase [Bacillus anthra...	562	potential drug target / Known drug target or ortholog of known drug target	Phase 5: 2010	1BS2	36.4%	Bacillus anthracis	Protein synthesis: tRNA aminoacylation

IDP91267 (show subtarget assignments)	8	cloned	No	NT05BA2321	49179114		protein export protein prsA [Bacillus an...	283	potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...	Community Requests	3RFW	25.4%	Bacillus anthracis	Protein fate: Protein folding and stabilization

IDP05179 (show subtarget assignments)	1	soluble	No	BA_3367	30257910		LPXTG-motif cell wall anchor domain prot...	595	associated with virulence and/or pathogenesis; vaccine candidate	Phase 5: 2010			Bacillus anthracis	Cell envelope: Other

IDP91900 (show subtarget assignments)	8	selected	No	SpneCM_010100003670	298254699		ABC transporter, ATP-binding/permease pr...	581	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3B5X	32.9%	Streptococcus pneumoniae

IDP91899 (show subtarget assignments)	8	selected	No	SpneCM_010100002520	298254473		ABC transporter, ATP-binding/permease pr...	564	Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...	Community Requests	3QF4	39.1%	Streptococcus pneumoniae

IDP05152
(show subtarget assignments)

1

cloned

No

BA_0420

30253954

conserved hypothetical protein [Bacillus...

265

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05151
(show subtarget assignments)

1

purified

No

BA_0307

30253847

putative lipoprotein [Bacillus anthracis...

397

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2QX2

29%

Bacillus anthracis

Cell envelope: Other

IDP05511
(show subtarget assignments)

1

soluble

No

BA_5634

30260085

putative lipoprotein [Bacillus anthracis...

196

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05500
(show subtarget assignments)

1

cloned

No

CD0261

126697833

fliQ

flagellar export protein [Clostridium di...

89

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05611
(show subtarget assignments)

1

expressed

No

BA_5156

30259642

conserved hypothetical protein [Bacillus...

208

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP91260
(show subtarget assignments)

8

soluble

No

NT02SA2397

14248172

nasF

uroporphyrin-III C-methyl transferase [S...

325

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1PJQ

28%

Staphylococcus aureus

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP91005
(show subtarget assignments)

8

soluble

No

y1936

22125828

ATP-binding component of a transport sys...

257

potential drug target / part of iron-sulfur cluster assembly system active under stress conditions

Community Requests

2ZU0

80.9%

Yersinia pestis

IDP04350
(show subtarget assignments)

1

cloned

No

STM1338_1_795

16764689

pheT

phenylalanyl-tRNA synthetase subunit bet...

795

Salmonella essential protein

Phase 4: April 2009

3PCO

92.6%

Salmonella enterica

IDP05499
(show subtarget assignments)

1

soluble

No

BA_4322

30258823

5'-nucleotidase family protein [Bacillus...

529

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2Z1A

30.2%

Bacillus anthracis

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05543
(show subtarget assignments)

1

cloned

No

CD2628

126700242

hypothetical protein CD2628 [Clostridium...

642

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05150
(show subtarget assignments)

1

in_crystallization_trials

No

BA_0195

30253702

putative oligopeptide ABC transporter, o...

546

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1B05

29.9%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05054
(show subtarget assignments)

1

cloned

No

CD0250

126697821

fliH

flagellar assembly protein [Clostridium ...

243

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04060
(show subtarget assignments)

8

selected

No

CAC05813

12329082

mxiI

MxiI, component of the Mxi-Spa secretion...

97

Shigella effector protein

Community Requests

Shigella flexneri

IDP05502
(show subtarget assignments)

1

cloned

No

CD0386

126697956

putative collagen-binding surface protei...

1014

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP05506
(show subtarget assignments)

1

soluble

No

CD1232

126698828

putative lipoprotein [Clostridium diffic...

273

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1NA0

15.8%

Clostridium difficile

Unknown function: General

IDP05507
(show subtarget assignments)

1

cloned

No

BA_5374

30259847

putative lipoprotein [Bacillus anthracis...

161

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05505
(show subtarget assignments)

1

cloned

No

CD1029

126698613

putative cell wall anchored protein [Clo...

553

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Regulatory functions: Other

IDP91081
(show subtarget assignments)

8

cloned

No

CD2817

126700433

ABC transporter, ATP-binding/permease pr...

596

drug resistance / The proteins of interest on the list are multi drug resistance transporters. Mu...

Community Requests

3QF4

39.4%

Clostridium difficile

IDP91205
(show subtarget assignments)

8

soluble

No

BT_3975

29349383

3-dehydroquinate synthase [Bacteroides t...

353

potential drug target / Shikimate pathway enzyme

Community Requests

3CLH

34.3%

Bacteroides thetaiotaomicron

IDP05099
(show subtarget assignments)

1

cloned

No

CD0754

126698334

thiI

thiamine biosynthesis protein ThiI [Clos...

391

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2C5S

42.2%

Clostridium difficile

Protein synthesis: tRNA and rRNA base modification

IDP05022
(show subtarget assignments)

1

cloned

No

CD1145

126698740

mreB2

rod shape-determining protein MreB [Clos...

353

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1JCE

54.4%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP05021
(show subtarget assignments)

1

soluble

No

CD1139

126698733

rnfG

electron transport complex protein [Clos...

189

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05749
(show subtarget assignments)

1

cloned

No

Cj0775c

6968216

valS

putative periplasmic protein [Campylobac...

870

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1GAX

38.2%

Campylobacter jejuni

Protein synthesis: tRNA aminoacylation

IDP05020
(show subtarget assignments)

1

soluble

No

CD1027

126698611

potD

spermidine/putrescine ABC transporter,su...

350

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4EQB

39.1%

Clostridium difficile

Transport and binding proteins: Amino acids, peptides and amines

IDP05508
(show subtarget assignments)

1

cloned

No

BA_5398

30259871

putative lipoprotein [Bacillus anthracis...

143

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05019
(show subtarget assignments)

1

expressed

No

CD0267

126697839

hypothetical protein CD0267 [Clostridium...

145

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Hypothetical proteins: Conserved

IDP05026
(show subtarget assignments)

1

cloned

No

BA_0025

30253539

putative csfB protein [Bacillus anthraci...

59

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: General

IDP04599
(show subtarget assignments)

1

cloned

No

BAS2268

49185277

aspartate-semialdehyde dehydrogenase [Ba...

347

Proposed to be essential proteins

Phase 4: April 2009

2GYY

55.3%

Bacillus anthracis

IDP04357
(show subtarget assignments)

1

in_crystallization_trials

No

FTT0894

56707995

purCD

fusion protein PurC/PurD [Francisella tu...

770

conserved gene; putative drug target function;

Phase 4: April 2009

2YRW

20.3%

Francisella tularensis

IDP05059
(show subtarget assignments)

1

soluble

No

CD0690

126698269

putative nucleotide phosphodiesterase [C...

655

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3GVE

15.3%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP05517
(show subtarget assignments)

1

soluble

No

CD1699

126699305

ribB

riboflavin synthase subunit alpha [Clost...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1KZL

38.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05183
(show subtarget assignments)

1

soluble

No

BA_5237

30259716

putative lipoprotein [Bacillus anthracis...

176

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP91381
(show subtarget assignments)

8

cloned

No

VV1_1469

27364853

Beta-galactosidase/beta-glucuronidase [V...

258

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

Vibrio vulnificus

IDP04538
(show subtarget assignments)

8

in_crystallization_trials

No

CAC05770

12329039

ospB

OspB, protein secreted by the Mxi-Spa se...

288

Shigella effector protein

Community Requests

Shigella flexneri

IDP91051
(show subtarget assignments)

8

in_crystallization_trials

No

PRM0001

81687074

rmtC

16S rRNA methylase [Proteus mirabilis]

281

drug resistance / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3B89

29.2%

Proteus mirabilis

IDP05516
(show subtarget assignments)

1

soluble

No

CD1697

126699303

ribH

riboflavin synthase beta chain (6,7-dime...

158

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RVV

66.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05024
(show subtarget assignments)

1

soluble

No

BAS4675

49187666

-

ABC transporter, substrate-binding prote...

325

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3IX1

20.6%

Bacillus anthracis

Unclassified: Role category not yet assigned

IDP05527
(show subtarget assignments)

1

cloned

No

CD2600

126700220

putative carbon starvation [Clostridium ...

473

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

Clostridium difficile

Cellular processes: Adaptations to atypical conditions

IDP04623
(show subtarget assignments)

1

expressed

No

BAS4760

49187751

glucose-1-phosphate adenylyltransferase ...

376

Proposed to be essential proteins

Phase 4: April 2009

3BRK

40%

Bacillus anthracis

IDP04024
(show subtarget assignments)

1

cloned

No

BAS5319

49188303

DNA-binding response regulator YycF [Bac...

235

Proposed to be essential proteins

Phase 4: April 2009

2OQR

47.7%

Bacillus anthracis

IDP05514
(show subtarget assignments)

1

purified

No

CD1315

126698913

ribC

riboflavin biosynthesis protein [Clostri...

309

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1MRZ

32.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Riboflavin, FMN, and FAD

IDP05513
(show subtarget assignments)

1

cloned

No

CD0278

126697850

putative transcriptional regulator [Clos...

130

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

4A5M

34.6%

Clostridium difficile

Regulatory functions: DNA interactions

IDP05518
(show subtarget assignments)

1

cloned

No

CD1702

126699308

thiC

thiamine biosynthesis protein ThiC [Clos...

438

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3EPM

43.1%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP04026
(show subtarget assignments)

1

expressed

No

FTT0456c

56707598

hypothetical protein FTT_0456c [Francise...

97

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1YHD

39.2%

Francisella tularensis

IDP05125
(show subtarget assignments)

1

cloned

No

BA_4310

30258811

putative lipoprotein [Bacillus anthracis...

246

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05029
(show subtarget assignments)

1

cloned

No

BA_0864

30254614

putative lipoprotein [Bacillus anthracis...

198

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP05520
(show subtarget assignments)

1

soluble

No

CD1822

126699430

bcp

putative thiol peroxidase (bacterioferri...

154

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3DRN

42.6%

Clostridium difficile

Cellular processes: Detoxification

IDP05519
(show subtarget assignments)

1

cloned

No

CD1704

126699311

thiG

thiazole synthase [Clostridium difficile...

261

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1XM3

47.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Thiamine

IDP05521
(show subtarget assignments)

1

cloned

No

CD1858

126699468

putative cell surface protein [Clostridi...

526

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Cell envelope: Other

IDP04067
(show subtarget assignments)

1

purified

No

BAS4417

49187412

thioredoxin [Bacillus anthracis str. Ste...

104

Proposed to be essential proteins

Phase 4: April 2009

2GZY

75%

Bacillus anthracis

IDP05690
(show subtarget assignments)

1

cloned

No

lmo1666

16803706

-

peptidoglycan linked protein (LPXTG) [Li...

1711

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Listeria monocytogenes

Protein fate: Degradation of proteins, peptides, and glycopeptides

IDP05523
(show subtarget assignments)

1

soluble

No

CD2204

126699821

esterase [Clostridium difficile 630]

260

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2UZ0

33.5%

Clostridium difficile

Fatty acid and phospholipid metabolism: Degradation

IDP05098
(show subtarget assignments)

1

purified

No

CD0569

126698147

putative outer membrane lipoprotein [Clo...

334

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FQW

21.3%

Clostridium difficile

Cell envelope: Other

IDP04539
(show subtarget assignments)

8

in_crystallization_trials

No

CAC05775

12329044

ospD1

OspD1, secreted by the Mxi-Spa secretion...

225

Shigella effector protein

Community Requests

Shigella flexneri

IDP05526
(show subtarget assignments)

1

soluble

No

CD1319

126698918

putative polysaccharide deacetylase [Clo...

247

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2J13

27.1%

Clostridium difficile

Energy metabolism: Biosynthesis and degradation of polysaccharides

IDP05541
(show subtarget assignments)

1

cloned

No

CD3437

126701060

cobS

cobalamin synthase [Clostridium difficil...

257

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RH5

23.5%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05524
(show subtarget assignments)

1

cloned

No

CD2402

126700017

putative cell wall hydrolase [Clostridiu...

396

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3H41

20.5%

Clostridium difficile

Cellular processes: Sporulation and germination

IDP05025
(show subtarget assignments)

1

cloned

No

BAS4742

49187733

-

hypothetical protein BAS4742 [Bacillus a...

200

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05130
(show subtarget assignments)

1

cloned

No

CD0119

126697691

phosphoglucomutase/phosphomannomutase mu...

454

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3PDK

50.2%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP04025
(show subtarget assignments)

1

expressed

No

YPCD1.36c

16082724

yscX

hypothetical protein YPCD1.36c [Yersinia...

122

virulence factor; conserved gene;

Phase 4: April 2009

Yersinia pestis

IDP05056
(show subtarget assignments)

1

soluble

No

CD0257

126697829

motB

chemotaxis protein [Clostridium difficil...

231

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2K1S

20.3%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP05528
(show subtarget assignments)

1

in_pdb
4E1L

No

CD2676

126700290

thlA2

putative acetyl-CoA acetyltransferase [C...

392

virulence/pathogenesis / Targets associated with virulence and/or pathogenesis

Phase 5: 2010

4E1L

100%

Clostridium difficile

Cellular processes: Toxin production and resistance

IDP05680
(show subtarget assignments)

1

purified

No

lmo1221

16803261

pheS

phenylalanyl-tRNA synthetase subunit alp...

350

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

2RHQ

55.1%

Listeria monocytogenes

Protein synthesis: tRNA aminoacylation

IDP05174
(show subtarget assignments)

1

cloned

No

BA_2570

30257192

conserved hypothetical protein [Bacillus...

245

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05540
(show subtarget assignments)

1

cloned

No

CD3515

126701139

glmU

bifunctional protein [Clostridium diffic...

459

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

4AAW

48.4%

Clostridium difficile

Central intermediary metabolism: Amino sugars

IDP04617
(show subtarget assignments)

1

expressed

No

BAS4342

49187337

50S ribosomal protein L21 [Bacillus anth...

102

Proposed to be essential proteins

Phase 4: April 2009

1VSA

54.9%

Bacillus anthracis

IDP05129
(show subtarget assignments)

1

cloned

No

CD0091

126697661

adk

adenylate kinase [Clostridium difficile ...

221

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3FB4

57.9%

Clostridium difficile

Purines, pyrimidines, nucleosides, and nucleotides: Nucleotide and nucleoside interconversions

IDP05028
(show subtarget assignments)

1

purified

No

BA_0331

30253869

polysaccharide deacetylase-like protein ...

367

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Unknown function: General

IDP04600
(show subtarget assignments)

1

cloned

No

BAS2547

49185555

preprotein translocase subunit SecY [Bac...

434

Proposed to be essential proteins

Phase 4: April 2009

3DIN

42.2%

Bacillus anthracis

IDP04066
(show subtarget assignments)

8

selected

No

CAC05819

12329088

mxiE

MxiE, similarities to transcriptional ac...

210

Shigella effector protein

Community Requests

Shigella flexneri

IDP05531
(show subtarget assignments)

1

cloned

No

CD2770

126700386

putative capsular polysaccharide biosynt...

363

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3C48

25.3%

Clostridium difficile

Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

IDP05530
(show subtarget assignments)

1

cloned

No

CD1534

126699138

putative gamma-glutamyltranspeptidase [C...

521

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2NLZ

54.7%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Glutathione and analogs

IDP05058
(show subtarget assignments)

1

in_crystallization_trials

No

CD0468

126698044

malL

oligo-1,6-glucosidase [Clostridium diffi...

554

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2ZE0

44%

Clostridium difficile

Energy metabolism: Sugars

IDP04601
(show subtarget assignments)

1

in_pdb
3RHI

Yes

BAS3574

49186575

DNA-binding protein HU [Bacillus anthrac...

90

Proposed to be essential proteins

Phase 4: April 2009

3RHI

100%

Bacillus anthracis

IDP05173
(show subtarget assignments)

1

expressed

No

BA_2528

30257152

N-acetylmuramoyl-L-alanine amidase, fami...

410

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3PYW

23.2%

Bacillus anthracis

Cell envelope: Surface structures

IDP05027
(show subtarget assignments)

1

purified

No

BA_0231

30253731

putative oligopeptide ABC transporter, o...

555

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRF

27.3%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP05154
(show subtarget assignments)

1

soluble

No

BA_0796

30254387

conserved hypothetical protein [Bacillus...

386

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Hypothetical proteins: Conserved

IDP04607
(show subtarget assignments)

1

cloned

No

BAS3700

49186699

ribonuclease III [Bacillus anthracis str...

245

Proposed to be essential proteins

Phase 4: April 2009

1O0W

40%

Bacillus anthracis

IDP05535
(show subtarget assignments)

1

cloned

No

CD3071

126700688

glycosyl hydrolase [Clostridium difficil...

692

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

2XVG

22.3%

Clostridium difficile

Unknown function: Enzymes of unknown specificity

IDP05533
(show subtarget assignments)

1

cloned

No

CD2149

126699765

hypothetical protein CD2149 [Clostridium...

419

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP05539
(show subtarget assignments)

1

in_pdb
4E16

No

CD3426

126701049

cbiF

precorrin-4 C(11)-methyltransferase [Clo...

250

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

4E16

100%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05534
(show subtarget assignments)

1

in_crystallization_trials

No

CD3106

126700723

putative phopho-sugar aldolase [Clostrid...

213

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

3R8R

35.2%

Clostridium difficile

Unknown function: General

IDP05538
(show subtarget assignments)

1

cloned

No

CD3392

126701015

putative collagen-binding surface protei...

1014

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Unknown function: General

IDP05127
(show subtarget assignments)

1

soluble

No

BA_4652

30259150

putative substrate-binding family protei...

314

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3HXP

29.6%

Bacillus anthracis

Transport and binding proteins: Unknown substrate

IDP05153
(show subtarget assignments)

1

soluble

No

BA_0656

30254258

oligopeptide ABC transporter, oligopepti...

593

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3DRF

32.4%

Bacillus anthracis

Transport and binding proteins: Amino acids, peptides and amines

IDP91384
(show subtarget assignments)

8

in_pdb
3UPD

Yes

VV1_1466

27364850

ornithine carbamoyltransferase [Vibrio v...

334

essential/virulence/pathogenesis / Targets from Vibrio parahaemolyticus and Vibrio vulnificus 1. Predicted essenti...

Community Requests

3UPD

100%

Vibrio vulnificus

IDP05128
(show subtarget assignments)

1

soluble

No

BA_5530

30259989

conserved hypothetical protein [Bacillus...

236

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

2FPN

29.2%

Bacillus anthracis

Hypothetical proteins: Conserved

IDP05537
(show subtarget assignments)

1

cloned

No

CD3419

126701042

hemB

delta-aminolevulinic acid dehydratase [C...

321

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1W5Q

55.2%

Clostridium difficile

Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin

IDP05536
(show subtarget assignments)

1

cloned

No

CD3145

126700762

putative serine-aspartate-rich surface a...

1190

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

1YO8

7.6%

Clostridium difficile

Unknown function: General

IDP05057
(show subtarget assignments)

1

cloned

No

CD0266

126697838

fliA

RNA polymerase sigma factor for flagella...

233

essential/virulence/pathogenesis / Targets showing phylogenetic evidence for essentiality, virulence or pathogenesi...

Phase 5: 2010

1RP3

38.2%

Clostridium difficile

Cellular processes: Chemotaxis and motility

IDP04646
(show subtarget assignments)

1

soluble

No

FTT1085

56708168

hypothetical protein FTT_1085 [Francisel...

332

drug target; conserved gene; putative drug target function;

Phase 4: April 2009

1QXN

9.3%

Francisella tularensis

IDP91277
(show subtarget assignments)

8

soluble

No

NT05BA4403

49181145

conserved hypothetical protein [Bacillus...

336

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

1JQJ

17.3%

Bacillus anthracis

DNA metabolism: DNA replication, recombination, and repair

IDP05248
(show subtarget assignments)

1

expressed

No

lmo2691

16804728

-

autolysin [Listeria monocytogenes EGD-e]...

590

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

3FI7

16.1%

Listeria monocytogenes

Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan

IDP91219
(show subtarget assignments)

1

cloned

No

SAOUHSC_01359

110810462

RecName: Full=Phosphatidylglycerol lysyl...

840

virulence/pathogenesis / Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound...

Community Requests

Staphylococcus aureus

IDP05134
(show subtarget assignments)

1

soluble

No

CD0555

126698134

sip2

singal peptidase I [Clostridium difficil...

178

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Clostridium difficile

Protein fate: Protein and peptide secretion and trafficking

IDP05141
(show subtarget assignments)

1

cloned

No

BAS2021

49185032

argS

arginyl-tRNA synthetase [Bacillus anthra...

562

potential drug target / Known drug target or ortholog of known drug target

Phase 5: 2010

1BS2

36.4%

Bacillus anthracis

Protein synthesis: tRNA aminoacylation

IDP91267
(show subtarget assignments)

8

cloned

No

NT05BA2321

49179114

protein export protein prsA [Bacillus an...

283

potential drug target / These targets are similar to actual drug targets and will be used mostly for coc...

Community Requests

3RFW

25.4%

Bacillus anthracis

Protein fate: Protein folding and stabilization

IDP05179
(show subtarget assignments)

1

soluble

No

BA_3367

30257910

LPXTG-motif cell wall anchor domain prot...

595

associated with virulence and/or pathogenesis; vaccine candidate

Phase 5: 2010

Bacillus anthracis

Cell envelope: Other

IDP91900
(show subtarget assignments)

8

selected

No

SpneCM_010100003670

298254699

ABC transporter, ATP-binding/permease pr...

581

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3B5X

32.9%

Streptococcus pneumoniae

IDP91899
(show subtarget assignments)

8

selected

No

SpneCM_010100002520

298254473

ABC transporter, ATP-binding/permease pr...

564

Predicted surface-exposed protein on Streptococcus pneumoniae str. MDR Canada 19...

Community Requests

3QF4

39.1%

Streptococcus pneumoniae